psoralens

Summary

Summary: Linear furanocoumarins which are found in many PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA from which they were originally discovered. They can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate PYRIMIDINES, resulting in PHOTOSENSITIVITY DISORDERS.

Top Publications

  1. ncbi Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips
    Edwin Ostertag
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 50:2565-70. 2002
  2. ncbi Psoralen derivatives and longwave ultraviolet irradiation are active in vitro against human melanoma cell line
    Vanessa Carneiro Leite
    Physiological Sciences Department, Federal University of Goias, 74001 970 Goiania, Brazil
    J Photochem Photobiol B 76:49-53. 2004
  3. pmc Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate
    Weimin Li
    Departments of Entomology and Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 100:14593-8. 2003
  4. ncbi Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 950 Lublin, Poland
    Pharmacol Rep 62:1231-6. 2010
  5. ncbi Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase
    Marc Hehmann
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 271:932-40. 2004
  6. ncbi Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin
    Ilaria Lampronti
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Eur J Haematol 71:189-95. 2003
  7. doi Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis
    Romain Larbat
    UMR 1121 Nancy Université Institut National de la Recherche Agronomique Agronomie Environnement Nancy Colmar, 2 Avenue de la Foret de Haye, 54505 Vandoeuvre les Nancy, France
    J Biol Chem 284:4776-85. 2009
  8. doi Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs
    Ilaria Lampronti
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara, 74, 44100, Ferrara, Italy
    Int J Hematol 90:318-27. 2009
  9. ncbi Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis
    Romain Larbat
    UMR 1121 Agronomie Environment INPL INRA, ENSAIA, Vandoeuvre les Nancy, France
    J Biol Chem 282:542-54. 2007
  10. doi Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function
    Anna Tamanini
    Laboratory of Molecular Pathology, Univ Hospital of Verona, Italy
    Am J Physiol Lung Cell Mol Physiol 300:L380-90. 2011

Research Grants

  1. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
  2. SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCER
    MADHUKAR PATHAK; Fiscal Year: 1990
  3. SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCER
    MADHUKAR PATHAK; Fiscal Year: 1980
  4. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2007
  5. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2009
  6. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2009
  7. The contribution of DNA interstrand crosslinks to aging
    LAURA JANE NIEDERNHOFER; Fiscal Year: 2010
  8. The contribution of DNA interstrand crosslinks to aging
    LAURA JANE NIEDERNHOFER; Fiscal Year: 2010
  9. CHARACTERIZATION OF PSORALEN DNA PHOTOADDUCTS
    FRANCIS GASPARRO; Fiscal Year: 1990
  10. Mechanisms of Psoralen-Induced Reproductive Toxicity
    MOUSSA DIAWARA; Fiscal Year: 2002

Detail Information

Publications203 found, 100 shown here

  1. ncbi Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips
    Edwin Ostertag
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 50:2565-70. 2002
    ..41 mg/kg, suggesting that properly stored roots/preparations have been used. It is recommended that, after harvesting, parsnips be kept at -18 degrees C or under other conditions that prevent microbial infections...
  2. ncbi Psoralen derivatives and longwave ultraviolet irradiation are active in vitro against human melanoma cell line
    Vanessa Carneiro Leite
    Physiological Sciences Department, Federal University of Goias, 74001 970 Goiania, Brazil
    J Photochem Photobiol B 76:49-53. 2004
    ..b>Psoralens are a group of compounds that bind to DNA in rapidly dividing cells and with ultraviolet light in the A band (..
  3. pmc Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate
    Weimin Li
    Departments of Entomology and Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 100:14593-8. 2003
    ..Further diversification of Papilio CYP6Bs has likely involved interspersed events of positive selection in oligophagous species and relaxation of functional constraints in polyphagous species...
  4. ncbi Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study
    Jarogniew J Łuszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 950 Lublin, Poland
    Pharmacol Rep 62:1231-6. 2010
    ....
  5. ncbi Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase
    Marc Hehmann
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 271:932-40. 2004
    Plants belonging to the Apiaceae or Rutaceae accumulate methoxylated psoralens, such as bergapten or xanthotoxin, as the final products of their furanocoumarin biosynthesis, and the rate of accumulation depends on environmental and other ..
  6. ncbi Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin
    Ilaria Lampronti
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Eur J Haematol 71:189-95. 2003
    ..Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of ..
  7. doi Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis
    Romain Larbat
    UMR 1121 Nancy Université Institut National de la Recherche Agronomique Agronomie Environnement Nancy Colmar, 2 Avenue de la Foret de Haye, 54505 Vandoeuvre les Nancy, France
    J Biol Chem 284:4776-85. 2009
    ..Accordingly, CYP71AJ3 and CYP71AJ4 might be derived from a common ancestor of unknown functionality by gene duplication and subsequent molecular evolution...
  8. doi Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs
    Ilaria Lampronti
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara, 74, 44100, Ferrara, Italy
    Int J Hematol 90:318-27. 2009
    ....
  9. ncbi Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis
    Romain Larbat
    UMR 1121 Agronomie Environment INPL INRA, ENSAIA, Vandoeuvre les Nancy, France
    J Biol Chem 282:542-54. 2007
    ..The studies suggested that several point mutations are necessary to pave the road toward angelicin synthase evolution...
  10. doi Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function
    Anna Tamanini
    Laboratory of Molecular Pathology, Univ Hospital of Verona, Italy
    Am J Physiol Lung Cell Mol Physiol 300:L380-90. 2011
    ..Finally, since psoralens have been shown to potentiate cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride ..
  11. doi Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage
    Paola Barraja
    Dipartimento Farmacochimico, Tossicologico e Biologico, Universita degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy
    Bioorg Med Chem 18:4830-43. 2010
    ..The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action...
  12. ncbi New insights on how nucleotide excision repair could remove DNA adducts induced by chemotherapeutic agents and psoralens plus UV-A (PUVA) in Escherichia coli cells
    Claudia Lage
    Laboratório de Radiobiologia Molecular, Instituto de Biofisica Carlos Chagas Filho, Bloco G, Centro de Ciencias da Saude, Universidade de Federal do Rio de Janeiro, 21949 900 Rio de Janeiro, RJ, Brazil
    Mutat Res 544:143-57. 2003
    ..Additionally, psoralens plus UV-A (PUVA), which also induce ICL, find use in treatment of patients afflicted with psoriasis and vitiligo...
  13. ncbi Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1171:334-44. 2009
    In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation...
  14. ncbi Efficacy of local psoralen ultraviolet A treatments in psoriasis, vitiligo and eczema
    E Adisen
    Clin Exp Dermatol 33:344-5. 2008
  15. ncbi A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants
    Guilhem Vialart
    UMR 1121 Lorraine University, INRA Agronomie et Environnement Nancy Colmar, ENSAIA, 2 Avenue de la Foret de Haye, 54505 Vandœuvre Lès Nancy, France
    Plant J 70:460-70. 2012
    ..Psoralen, which is an important furanocoumarin in R. graveolens, was found to be a competitive inhibitor of the enzyme, and it may exert this effect through negative feedback on the enzyme at an upstream position in the pathway...
  16. ncbi Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Biochem Pharmacol 75:810-25. 2008
    b>Psoralens, also known as furocoumarins, are a class of photosensitizers largely used in the therapy of various skin diseases...
  17. ncbi Triple helix-directed psoralen crosslinks are recognized by Uvr(A)BC excinuclease
    G Duval-Valentin
    Laboratoire de Biophysique, Museum national d histoire naturelle, INSERM U201, CNRS UA 481, Paris, France
    J Mol Biol 278:815-25. 1998
    ....
  18. ncbi Transcription dependence of chromosomal gene targeting by triplex-forming oligonucleotides
    Margaret A Macris
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    J Biol Chem 278:3357-62. 2003
    ..These findings provide evidence that physiologic activity at a chromosomal target site can influence its accessibility to TFOs and suggest that gene targeting by small molecules may be most effective at highly expressed chromosomal loci...
  19. pmc Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells
    Sophie Couve-Privat
    Group DNA repair, UMR 8126 of CNRS and Group FANC BRCA pathway and Cancer FRE2939 of CNRS, University of Paris South, Institute Gustave Roussy, Villejuif Cedex, F 94805, France
    Nucleic Acids Res 35:5672-82. 2007
    ..Furthermore, we demonstrate that bacterial homologues of NEIL1, the Fpg and Nei proteins, also excise MAs. New substrate specificity of the Fpg/Nei protein family provides an alternative repair pathway for ICLs and bulky DNA damage...
  20. pmc Repair of 4,5',8-trimethylpsoralen monoadducts and cross-links by the Escherichia coli UvrABC endonuclease
    B K Jones
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 85:8410-4. 1988
    ..The incisions are not equally efficient. These data suggest that the structure of a psoralen cross-link, as seen by a repair enzyme, varies with the DNA sequence...
  21. ncbi Contribution of XPF functional domains to the 5' and 3' incisions produced at the site of a psoralen interstrand cross-link
    Kandallu R Kumaresan
    Department of Pathology and Laboratory Medicine, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Biochemistry 41:890-6. 2002
    ....
  22. ncbi Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens
    D Papadopoulo
    Section de Biologie, Institut Curie, UA 1292 CNRS, Paris, France
    Cancer Res 50:3289-94. 1990
    ..the hypoxanthine-guanine phosphoribosyltransferase and Na+/K+ ATPase loci by photoaddition of two bifunctional psoralens was compared in normal and in Fanconi's anemia lymphoblasts from the genetic complementation group A...
  23. ncbi Cinnamic acid 4-hydroxylase mechanism-based inactivation by psoralen derivatives: cloning and characterization of a C4H from a psoralen producing plant-Ruta graveolens-exhibiting low sensitivity to psoralen inactivation
    Antoine Gravot
    UMR 1121 Agronomie Environnement INPL INRA, ENSAIA 2, Av de la Forêt de Haye, 54505 Vandoeuvre Les Nancy Cedex, France
    Arch Biochem Biophys 422:71-80. 2004
    ..graveolens and P. crispum C4H that might tolerate substantial levels of psoralen derivatives in the cytoplasmic compartment without a depletive effect on C4H and the general phenylpropanoid metabolism...
  24. ncbi Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padua, Via Marzolo 5, 35131 Padua, Italy
    Photochem Photobiol Sci 3:237-9. 2004
    Treatment of cells with UVA radiation in combination with linear psoralens induces a cell-cycle block and subsequent apoptosis, whereas angular derivatives produce apoptosis without affecting the cellular cycle.
  25. ncbi Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography
    Nguyen Thanh Dong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 26:516-20. 2003
    ..The variation of the concentration of psoralen and angelicin was wide between different species. The seeds of Psoralea corylifolia showed the highest contents of psoralen (7.8 mg/g) and angelicin (2.3 mg/g) among the tested herbs...
  26. ncbi Mitochondrial alterations in fanconi anemia fibroblasts following ultraviolet A or psoralen photoactivation
    Solange Rousset
    UMR 218 CNRS, Institut Curie Recherche, Paris, France
    Photochem Photobiol 75:159-66. 2002
    ..These data are indicative of some sort of membrane damage induced by 8-MOP photoreaction and UVA irradiation, to which FA cells appear to be particularly sensitive...
  27. ncbi Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (dorstenia species) by high-performance liquid chromatography
    Cláudia A L Cardoso
    Universidade Estadual de Mato Grosso do Sul, Rod Ithaum, km 12, 79804 970, Dourados MS, Brazil
    J Agric Food Chem 50:1465-9. 2002
    ..Dorstenia tubicina and D. asaroides contained psoralen and bergapten only in the rhizomes, whereas D. vitifolia shows solely isopimpinellin in both rhizomes and aerial parts...
  28. ncbi Pharmacokinetic and toxicology assessment of INTERCEPT (S-59 and UVA treated) platelets
    V Ciaravi
    Cerus Corporation, Concord, California 94520, USA
    Hum Exp Toxicol 20:533-50. 2001
    ..Thus, the results of an extensive series of in vitro and in vivo studies have not demonstrated any toxicologically relevant effects of platelet concentrates prepared by the INTERCEPT system...
  29. ncbi 6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect
    Shefali M Kakar
    Department of Pharmacology, University of Michigan, Ann Arbor, USA
    Clin Pharmacol Ther 75:569-79. 2004
    ..Our objective was to assess the contribution of 6',7'-dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal cytochrome P450 (CYP) 3A4...
  30. ncbi Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase
    J S Chen
    Department of Plant Biology, University of Illinois, Urbana, IL 61801, USA
    Insect Mol Biol 11:175-86. 2002
    ..Conservation of Phe116 and His117 in an array of lepidopteran CYP6B proteins implies that these amino acids serve a similar function in other monooxygenases of the insect CYP6B subfamily...
  31. ncbi Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis
    D Lopes
    , Rio de Janeiro, Brazil
    Planta Med 67:820-4. 2001
    ..coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect...
  32. ncbi Inactivation of cytomegalovirus in platelet concentrates using Helinx technology
    L Lin
    Biological Research Division, Cerus Corporation, Concord, CA 94520, USA
    Semin Hematol 38:27-33. 2001
    ..In conclusion, Helinx technology offers a potential alternative to selection of CMV-seronegative units and to leukocyte-reduction filtration as a means to decrease the risk of transfusion-acquired CMV infection...
  33. ncbi Preclinical safety of a nucleic acid-targeted Helinx compound: a clinical perspective
    V Ciaravino
    Department of Preclinical Safety, Cerus Corporation, Concord, CA 94520, USA
    Semin Hematol 38:12-9. 2001
    ..The results of an extensive series of studies have thus demonstrated no toxicologically relevant effects of platelets treated with Helinx technology...
  34. ncbi Distribution of furanocoumarins in grapefruit juice fractions
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, US Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 53:5158-63. 2005
    ..MS analysis of this furanocoumarin-enriched fraction provided evidence of additional furanocoumarins in grapefruit juice that remain to be fully characterized and evaluated for their roles in the grapefruit-drug interactions...
  35. ncbi Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes
    Basavaraj Girennavar
    Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A and M University, College Station, TX 77843, USA
    Bioorg Med Chem 14:2606-12. 2006
    ..56+/-0.72 microM for the benzyloxy resorufin (BROD). DHB and bergamottin showed considerable variations for EROD and BROD activities with an IC50 of 7.17 microM and 13.86 microM, respectively...
  36. ncbi [Determination of psoralen and isopsoralen in Psoralea corylifolia L. from different habitats]
    Jiaxin Ding
    Institute of Chinese Medicine Basic Theory, China Academy of Traditional Chinese Medicine, Beijing
    Zhong Yao Cai 27:817-8. 2004
    ..To study the psoralen and isopsoralen content in Psoralea corylifolia from different habitats...
  37. ncbi Inhibition of in-vitro simvastatin metabolism in rat liver microsomes by bergamottin, a component of grapefruit juice
    N Le Goff-Klein
    UMR CNRS 7034, Faculte de Pharmacie, Universite Louis Pasteur, Strasbourg, France
    J Pharm Pharmacol 56:1007-14. 2004
    ..The results highlight the importance of validating in-vitro models to help verify the suitability of the in-vitro model for predicting the nature and degree of metabolic drug interactions...
  38. ncbi A method for fast determination of psoralens in oral solutions of phytomedicines using liquid chromatography
    Adriana Elias Pires
    Departamento de Quimica, Universidade Federal de Mato Grosso do Sul, Caixa Postal 649, 79070 900 Campo Grande MS, Brazil
    J Pharm Biomed Anal 36:415-20. 2004
    ..0-600.0 microg ml(-1) and 1.0-400.0 microg ml(-1) respectively. The recoveries of the psoralens in the oral solutions analysed were 94.43-99.97%...
  39. ncbi Novel pyrone side tetracyclic psoralen derivatives: synthesis and photobiological evaluation
    Lisa Dalla Via
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 46:3800-10. 2003
    ..AM1 calculations were also performed to gain further insight into the molecular basis of their photobiological behavior...
  40. ncbi Preparative isolation and purification of bergapten and imperatorin from the medicinal plant Cnidium monnieri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase
    Hua Bin Lia
    Department of Botany, The University ofHong Kong, Pokfulam Road, Hong Kong, China
    J Chromatogr A 1061:51-4. 2004
    ..The method yielded 45.8 mg of bergapten at 96.5% purity and 118.3 mg of imperatorin at 98.2% purity from 500 mg of the crude extract in a single run. The recoveries of bergapten and imperatorin were 92.1 and 93.7%, respectively...
  41. ncbi Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice
    David G Bailey
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Clin Pharmacol Ther 73:529-37. 2003
    ..Our objective was to assess the importance of bergamottin in drug interactions through comparisons between grapefruit juice and lime juice and the potential for drug interactions with red wine...
  42. ncbi 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica
    Melanie Muller
    Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
    Acta Pharm 54:277-85. 2004
    ..The results of comprehensive 2D NMR analyses of archangelicin are discussed...
  43. ncbi Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel
    H Wangensteen
    Department of Pharmacognosy, School of Pharmacy, University of Oslo, P O Box 1068 Blindern, N 0316, Oslo, Norway
    Eur J Clin Pharmacol 58:663-8. 2003
    ..Thus, the aim of this in vitro study was to identify CYP3A4 inhibitors in grapefruit peel...
  44. ncbi [Study on coumarin compounds from Exocarpium Citri Grandis]
    Zhixia Chen
    Guangdong Provincial Institute for Drug Control, Guangzhou
    Zhong Yao Cai 27:577-8. 2004
    ..To study the coumarin compounds from Exocarpium Citri Grandis...
  45. ncbi Apoptosis in leukocytes induced by UVA in the presence of 8-methoxypsoralen, chlorpromazine or 4,6,4'-trimethylangelicin
    Agnieszka Wolnicka-Głubisz
    Department of Biophysics, The Zurzycki Institute of Molecular Biology, Jagiellonian University, ul Gronostajowa 7, 30 387 Krakow, Poland
    J Photochem Photobiol B 68:65-72. 2002
    ..The results of the present study, combined with previous observations with the animal model for ECP, suggest that apoptosis is not likely to be a critical step in the cascade of events leading to immunosuppression...
  46. ncbi Inhibition of DNA polymerization and antifungal specificity of furanocoumarins present in traditional medicines
    Myron L Smith
    Biology Department, Carleton University, Ottawa, Ontario, Canada
    Photochem Photobiol 79:506-9. 2004
    ..Greater overall inhibition of DNA polymerization by Z. americanum husk extracts than with single or mixed furanocoumarins suggests that inhibitory compounds in addition to the major furanocoumarins are present in Z. americanum...
  47. ncbi Phototoxicity, distribution and kinetics of association of UVA-activated chlorpromazine, 8-methoxypsoralen, and 4,6,4'-trimethylangelicin in Jurkat cells
    Agnieszka Wolnicka-Głubisz
    Department of Biophysics, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    J Photochem Photobiol B 78:155-64. 2005
    ..A clear indication of photoinduced formation of reactive oxygen species and peroxidation of lipids was observed only in CPZ-sensitized cells, suggesting different mechanisms for phototoxicity mediated by CPZ and by the two furocoumarins...
  48. ncbi [Extraction of coumarins from Angelica dahurica by supercritical extraction and GC-MS analysis]
    Hong Mei Liu
    Biochemical Engineering College of Beijing Union University, Beijing 100023, China
    Zhongguo Zhong Yao Za Zhi 29:241-4. 2004
    ..To extract coumarins from Angelica Dahurica by supercritical CO2...
  49. ncbi Inhibition of P-glycoprotein transport function by grapefruit juice psoralen
    E J Wang
    Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, New Jersey 07848, USA
    Pharm Res 18:432-8. 2001
    ..Inhibition of P-gp by citrus psoralens could present ways both to enhance bioavailability of therapies without increasing the dose and to diminish drug ..
  50. ncbi The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae
    H H de Andrade
    Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Brazil
    Mol Gen Genet 217:419-26. 1989
    ..This indicates that the PSO4 gene is involved in an error-prone repair pathway which relies on a recombinational mechanism, strongly suggesting an analogy between the pso4-1 mutation and the RecA or LexA mutation of Escherichia coli...
  51. ncbi Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography
    Chun Feng Qiao
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, China
    J Sep Sci 30:813-8. 2007
    ..A more comprehensive analytical method was established for the fingerprint of Fructus Psoraleae. It is very useful for authentication and quality assessment of the crude drug...
  52. ncbi The increase in melanoma: are dietary furocoumarins responsible?
    Robert M Sayre
    Division of Dermatology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38104, United States
    Med Hypotheses 70:855-9. 2008
    ..Retrospective studies of PUVA patients show significantly increased incidence of CM. Psoralens, and other furocoumarins, are phototoxic and photocarcinogenic, intercalate DNA and photochemically induce ..
  53. pmc Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids
    Ki Hyun Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, P O Box 208040, New Haven, CT 06520 8040, USA
    Nucleic Acids Res 35:7604-13. 2007
    ..These results identify pcPNAs as new tools for site-specific gene modification in mammalian cells without purine sequence restriction, thereby providing a general strategy for designing gene targeting molecules...
  54. ncbi Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins
    B Girennavar
    Vegetable and Fruit Improvement Center, Dept of Horticultural Sciences, Texas A and M Univ, College Station TX 77843 2119, U S A
    J Food Sci 72:C417-21. 2007
    ..1 microM to 0.1 mM concentrations. The IC(50) value was lowest for paradisin A for CYP3A4 with 0.11 microM followed by DHB for CYP2C9 with 1.58 microM...
  55. ncbi [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC]
    Yue Shi
    School of Life Sciences and Engineerng, Tsinghua University, Beijing 100084, China
    Zhongguo Zhong Yao Za Zhi 29:950-2. 2004
    ..To develop a method for the determination of isoimperatorin and osthol in Ganmao Yixiaoshi capsule by RP-HPLC...
  56. ncbi [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC]
    De Xin Weng
    Zhejiang Deqing No 3 People Hospital, Deqing 313201, China
    Zhongguo Zhong Yao Za Zhi 32:1883-5. 2007
    ..To develop an RP-HPLC method for simultaneous determination of 5 constituents in Fructus Cnidii...
  57. ncbi Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors
    Aleksandra Orlita
    Faculty of Chemistry, University of Gdansk, PL 80 952 Gdansk, ul Sobieskiego 18, Gdansk, Poland
    Biotechnol Prog 24:128-33. 2008
    ..The use of saccharin also increased the production of bergapten, isopimpinelin, pinnarin, psoralen, and xanthotoxin several times...
  58. ncbi Determination of bergamottin in human plasma after grapefruit juice ingestion by an UPLC/MS/MS method
    Y Uesawa
    Clinical Pharmaceutics Laboratory, Department of Pharmaceutics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Pharmazie 63:110-2. 2008
    ..In conclusion, we succeeded high performance bergamottin-determination in human plasma after grapefruit juice ingestion. The procedure can be usefulto clarify pharmacokinetic and pharmacodynamic characteristics of bergamottin...
  59. ncbi Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine
    Mary F Paine
    School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
    Am J Clin Nutr 87:863-71. 2008
    ..It remains unclear whether furanocoumarins mediate drug-GFJ interactions involving CYP3A4 substrates that are also P-glycoprotein substrates...
  60. ncbi Rapid identification of some coumarin derivatives in deterpenated citrus peel oil by gas chromatography
    D Chouchi
    , , Nancy, France
    J Chromatogr A 672:177-83. 1994
    ..Terpeneless oils are used in perfumes and cosmetics, so it is important to be able to establish rapidly if they contain phototoxic compounds...
  61. doi Furocoumarins photolysis products induce differentiation of human erythroid cells
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, University of Padova, 35131 Padova, Italy
    J Photochem Photobiol B 92:24-8. 2008
    b>Psoralens, also known as furocoumarins, are a well-known class of photosensitizers largely used in the therapy of various skin disease...
  62. doi Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract
    Elias P Siskos
    Chemical Ecology and Natural Products Laboratory, NCSR Demokritos, 150 13 Aghia Paraskevi, Attikis, Greece
    J Agric Food Chem 56:5577-81. 2008
    ..6',7'-Epoxybergamottin was toxic when tested individually, while bergapten and osthol were found to act synergistically to 6',7'-epoxybergamottin...
  63. ncbi 4,5-Dimethylangelicin effects on lymphocytes with and without UV-radiation
    W Gast
    Department of Dermatology, School of Medicine, Karl Marx, University of Leipzig, GDR
    Farmaco Sci 42:185-90. 1987
    ..These findings suggest different action mechanisms on cytoplasma membranes and intracellular structures of lymphocytes by different furocoumarins...
  64. ncbi Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity
    Ilkay Orhan
    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    Z Naturforsch C 63:366-70. 2008
    ..3 +/- 0.23)%], 4-methylumbelliferone [(80.9 +/- 1.17)%], scopoletin [(73.5 +/- 1.01)%], 8-methoxypsoralen [(67.1 +/- 0.98)%], as well as the furanocoumarin mixture [(76.7 +/- 0.95)%] had a notable anti-BChE effect...
  65. ncbi A bioassay using the human hepatoblastoma cell line HepG2 for detecting phototoxicity of furocoumarins
    M Colombain
    Laboratoire de Pharmacognosie, , , place Saint-Jacques, , France
    Planta Med 67:644-6. 2001
    ..This easy-to-perform, miniaturised, quantitative and sensitive method could therefore be used as a primary screening test for phototoxicity of a large number of compounds and plant extracts...
  66. ncbi PSO4: a novel gene involved in error-prone repair in Saccharomyces cerevisiae
    J A Henriques
    Universidade Federal do Rio Grande do Sul, Departamento de Fisiologia, Farmacologia e Bioquímica, RS, Brasil
    Mutat Res 218:111-24. 1989
    ..coli SOS repair pathway...
  67. ncbi Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae)
    Victor Kuete
    Department of Biochemistry, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    J Ethnopharmacol 112:531-6. 2007
    ..The obtained results provide promising baseline information for the potential use of these crude extract as well as some of the isolated compounds in the treatment of bacterial and fungal infections...
  68. ncbi Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit
    Basavaraj Girennavar
    Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, 2119, Texas A and M University, College Station, TX 77843 2119, USA
    Bioorg Med Chem 15:3684-91. 2007
    ..Bergaptol and geranylcoumarin were found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC(50) value of 24.92 and 42.93 microM, respectively...
  69. pmc gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells
    Seiki Mogi
    Department of Dermatology, University of California, San Francisco, USA
    DNA Repair (Amst) 5:731-40. 2006
    ..Furthermore, XPA may be important to allow psoralen interstrand crosslinks to be processed without forming a double strand break intermediate...
  70. ncbi Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome p450 monooxygenase
    Jerome Baudry
    School of Chemical Sciences, University of Illinois at Urbana Champaign, 190 ERML, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Protein Eng 16:577-87. 2003
    ....
  71. ncbi A method for quantitative determination of furanocoumarins in capsules and tablets of phytochemical preparations
    Claudia Andréa Lima Cardoso
    Curso de Química, Universidade Estadual de Mato Grosso do Sul, Dourados MS, Brazil
    Chem Pharm Bull (Tokyo) 54:442-7. 2006
    ..3-99.5%, and the percent coefficient of variation for the quantitative analysis of the furanocoumarins in the analyses was under 5%. For inter-equipment study gas chromatography (GC) was employed...
  72. ncbi A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction
    Mary F Paine
    Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC, USA
    Am J Clin Nutr 83:1097-105. 2006
    ..Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear...
  73. ncbi Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies
    Whocely Victor De Castro
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O BOX 100494, Gainesville, Florida 32610 0494, USA
    J Agric Food Chem 54:249-55. 2006
    ..The concentration of potentially contributing compounds may crucially influence the magnitude of observed interaction and impair direct comparison of studies in which different juices have been used...
  74. ncbi The use of heat treatment to eliminate drug interactions due to grapefruit juice
    Yoshihiro Uesawa
    Clinical Pharmaceutics Laboratory, Department of Pharmaceutics, Meiji Pharmaceutical University, Kiyose, Japan
    Biol Pharm Bull 29:2274-8. 2006
    ..No significant increase in the AUC of NFP was observed in the rats given heat-treated GJ. These results suggest that the heat treatment of GJ reduces the concentrations of FCs, thus eliminating the potential for drug interactions...
  75. pmc Reproducible and inexpensive probe preparation for oligonucleotide arrays
    Y Zhang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 29:E66-6. 2001
    ..Validation of this protocol is demonstrated by hybridizing PCR products with oligonucleotide-coated microspheres and PCR amplified cDNA with Affymetrix Cancer GeneChip microarrays...
  76. ncbi Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?
    Paula E Beattie
    Photobiology Unit, Dermatology Department, University of Dundee, Ninewells Hospital and Medical School, United Kingdom
    J Am Acad Dermatol 56:84-7. 2007
    ..Threshold erythema was unaffected by ingestion of a 200-g portion of parsnip...
  77. ncbi [Comparation of constitutions between raw Psoralea corylifolia L. and processed one]
    Yan hua Guo
    Department of Pharmaceutical College of Liaoning Traditional Chinese Medicine, Shenyang 110032, China
    Zhong Yao Cai 29:1142-4. 2006
    ..To study the processing material foundation of Psoralea corylfolia L. and compare the content of psoralen, isopsoralen and microelement between raw Psoralea corylifolia L. and processed one...
  78. ncbi [Analysis of coumarins in Fructus Cnidii by HPLC-ESI-MS]
    Ying qiao Jiang
    Guangzhou Institute for Drug Control, Guangzhou 510160, China
    Zhong Yao Cai 29:1033-5. 2006
    ..To analyze coumarins in Fructus Cnidii by HPLC-ESI-MS...
  79. ncbi [Studies on chemical constituents from fruits of Paliurus ramosissimus]
    Lei Yu
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:2049-52. 2006
    ..To study the chemical constituents from the fruits of Paliurus ramosissimus...
  80. ncbi [Determination of coumarins content in Radix Angelicae dahuricae by HPLC and UV]
    Mengyue Wang
    School of Pharmacy, Shanghai Jiaotong University, Shanghai
    Zhong Yao Cai 27:826-8. 2004
    ..To determine the coumarins content in Radix Angelicae Dahuricae (Baizhi)...
  81. ncbi Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins
    S Malhotra
    Department of Pharmacology, University of Michigan, Ann Arbor, USA
    Clin Pharmacol Ther 69:14-23. 2001
    ....
  82. ncbi Novel therapies for psoriasis
    Jennifer Cather
    Baylor University Medical Center, Dallas, Texas, USA
    Am J Clin Dermatol 3:159-73. 2002
    ..vitamin D(3), and retinoid derivatives), either singly, in combination, or with ultraviolet B (UVB) or psoralens and ultraviolet A (PUVA) therapy, the role of systemic medications has assumed greater prominence...
  83. ncbi The Schnitzler syndrome. Four new cases and review of the literature
    D Lipsker
    Clinique Dermatologique, Hopitaux Universitaires, Strasbourg, France
    Medicine (Baltimore) 80:37-44. 2001
    ..is unresponsive to treatment, and nonsteroidal antiinflammatory drugs, antihistamines, dapsone, colchicine, and psoralens and ultraviolet A (PUVA) therapy give inconstant results...
  84. ncbi Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress
    Cristina Pungartnik
    Departamento de Biofisica Centro de Biotecnologia, UFRGS, Av Bento Goncalves, 9500, 91507 970 Porto Alegre, RS, Brazil
    Genet Mol Res 1:79-89. 2002
    ..The first three PSO genes of the DNA repair group and PSO3, apart from being sensitive to photo-activated psoralens, have another common phenotype: they are also involved in error-prone DNA repair...
  85. ncbi Clinically significant pharmacokinetic interactions between dietary caffeine and medications
    J A Carrillo
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
    Clin Pharmacokinet 39:127-53. 2000
    ..reuptake inhibitors (particularly fluvoxamine), antiarrhythmics (mexiletine), antipsychotics (clozapine), psoralens, idrocilamide and phenylpropanolamine, bronchodilators (furafylline and theophylline) and quinolones (enoxacin), ..
  86. ncbi Common pigmentation disorders
    Scott Plensdorf
    McLaren Family Practice Residency Program, MI, USA
    Am Fam Physician 79:109-16. 2009
    ..or generalized vitiligo may include cosmetic coverage, psoralen ultraviolet A-range therapy (with or without psoralens), or narrow-band ultraviolet-B therapy; whereas those with stable, limited disease may be candidates for ..
  87. ncbi Skin pigmentation enhancers
    D A Brown
    AGI Dermatics, 205 Buffalo Avenue, Freeport, NY 11520, USA
    J Photochem Photobiol B 63:148-61. 2001
    ..pigmentation: dihydroxyacetone and melanins; and substances that stimulate the natural pigmentation process: psoralens with UVA (PUVA), dimethylsulfoxide (DMSO), L-tyrosine, L-Dopa, lysosomotropic agents, diacylglycerols, thymidine ..
  88. ncbi UV irradiation affects melanocyte stimulatory activity and protein binding of piperine
    Amala Soumyanath
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Photochem Photobiol 82:1541-8. 2006
    ..This is unlike the situation with psoralens, which form DNA adducts when administered with UVA in treating skin diseases...
  89. ncbi Photoactivatable antisense DNA: suppression of ampicillin resistance in normally resistant Escherichia coli
    F P Gasparro
    Department of Dermatology, Yale University, New Haven, CT 06510
    Antisense Res Dev 1:117-40. 1991
    ..Irradiation of oligonucleotides and psoralens with long-wavelength ultraviolet radiation (380-400 nm) produced monoadducted antisense molecules...
  90. ncbi Psoralens percutaneous permeation across the human whole skin and the epidermis in respect to their polarity (in vitro study)
    A Said
    Laboratoire de Pharmacie Galenique, Faculte de Medecine et de Pharmacie, Besancon, France
    J Dermatol Sci 14:136-44. 1997
    ..choice of the suitable drug(s) for topical applications, with appropriate dosage, percutaneous permeation of the psoralens, in connection with their solubilities and partition coefficients in an octanol/water system, were investigated...
  91. pmc Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration
    Marcella Grundmann-Kollmann
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Br J Clin Pharmacol 54:535-9. 2002
    Photochemotherapy employing psoralens combined with UVA irradiation (PUVA) is a standard therapy for a variety of dermatoses. Psoralens can be administered orally or topically in the form of bath or cream preparations...
  92. ncbi Elimination of cytokine production in stored platelet concentrate aliquots by photochemical treatment with psoralen plus ultraviolet A light
    D J Hei
    Cerus Corp, Concord, California 94520, USA
    Transfusion 39:239-48. 1999
    ..methods of white cell inactivation were compared for their ability to reduce cytokine synthesis in pooled random-donor PC aliquots: treatment with gamma-radiation and photochemical treatment (PCT) using psoralens and ultraviolet A light.
  93. ncbi Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization
    L M Koulu
    Department of Dermatology, University of Turku, Finland
    J Am Acad Dermatol 18:1053-9. 1988
    Successful results have been reported for bath-psoralens plus ultraviolet A (PUVA) treatment of psoriasis with the use of either a low-sensitizing psoralen (methoxsalen) or a high-sensitizing psoralen (trioxsalen), but no evidence has ..
  94. ncbi The application of antioxidants in investigations and optimization of photochemotherapy
    A Y Potapenko
    Russian State Medical University, Moscow
    Membr Cell Biol 12:269-78. 1998
    b>Psoralens (furocoumarins) are photosensitizers of plant origin...
  95. ncbi Serum 5-S-cysteinyldopa levels in patients with psoriasis undergoing narrowband ultraviolet B phototherapy
    K Kikuchi
    Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Dermatol 33:750-3. 2008
    ..Narrowband UVB (NB-UVB), a relatively new light source that is not yet widely available, is effective for treating generalized psoriasis without the use of psoralens.
  96. ncbi Inactivation of leukocytes in platelet concentrates by photochemical treatment with psoralen plus UVA
    J A Grass
    Cerus Corp, Concord, CA 94520, USA
    Blood 91:2180-8. 1998
    ..Three psoralens, 8-methoxypsoralen (8-MOP), 4'-aminomethyl 4,5', 8-trimethylpsoralen (AMT), and the novel psoralen S-59, were ..
  97. doi UVA-induced phenoxyl radical formation: A new cytotoxic principle in photodynamic therapy
    Christine M Volkmar
    Department of Plastic and Reconstructive Surgery, Hand Surgery, and Burn Center, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    Free Radic Biol Med 49:1129-37. 2010
    b>Psoralens are regularly used in therapy in combination with ultraviolet A light irradiation (PUVA) to treat skin diseases such as psoriasis, vitiligo, and mycosis fungoides...
  98. ncbi LC-MS for the identification of oxygen heterocyclic compounds in citrus essential oils
    P Dugo
    Dipartimento di Chimica Organica e Biologica, Facolta di Scienze, Universita di Messina, Italy
    J Pharm Biomed Anal 24:147-54. 2000
    The oxygen heterocyclic compounds (coumarins, psoralens and polymethoxylated flavones) present in the nonvolatile residue of the essential oils of Mandarin, Sweet Orange, Bitter Orange, Bergamot and Grapefruit were analysed with an HPLC/..
  99. ncbi Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment
    Rolf Teschke
    Department of Internal Medicine II, University of Frankfurt Main and University of Duesseldorf, Germany
    Ann Hepatol 8:258-66. 2009
    ..a probable causality (+8 points) for Bakuchi tablets containing extracts from Psoralea corylifolia leaves with psoralens as ingredients, as the primary candidate causing the hepatotoxic reaction...
  100. ncbi 4'-Aminomethyl-4,5',8-trimethylpsoralen photochemistry: the effect of concentration and UVA fluence on photoadduct formation in poly(dA-dT) and calf thymus DNA
    A Oroskar
    Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439
    Photochem Photobiol 60:567-73. 1994
    ..Thus, for AMT, DNA base pair sites other than 5'TA, the well-characterized strong binding for psoralens in general, are an additional target for photomodification, which results in the formation of a higher ..
  101. ncbi Psoralens: novel modulators of Cl- secretion
    D C Devor
    Department of Cell Biology and Physiology, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 272:C976-88. 1997
    We evaluated effects of psoralens on Cl- secretion (short-circuit current, I(sc)) across T84 monolayers. Methoxsalen failed to increase I(sc)...

Research Grants92

  1. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..hydrolyzable compounds such as 2- proprionolactone and ozone;and photochemical decontamination using synthetic psoralens. Thus, current approaches are not always effective against a wide spectrum of human and animal viruses, are ..
  2. SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCER
    MADHUKAR PATHAK; Fiscal Year: 1990
    ..and synthetic alpha-MSH melanotrophins; d) role of reactive 02 species in cutaneous phototoxic reactions by psoralens; and e) role of cutaneous involving the alterations of collagen, glycosaminoglycans, elastin, and certain ..
  3. SKIN REACTION TO LIGHT--NORMAL, PHOTOSENSITIVITY, CANCER
    MADHUKAR PATHAK; Fiscal Year: 1980
    ..The concept of metabolic activation of psoralens by hepatic microsomal enzymes and their interaction with DNA, RNA, or proteins to become a "chemical carcinogen" ..
  4. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2007
    ..ERCCl-XPF-deficient cells will be exposed to 8-MOP or angelicin, plant-derived psoralens. Photoactivation of 8-MOP induces ICLs and monoadducts, whereas angelicin produces only monoadducts...
  5. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2009
    ..ERCCl-XPF-deficient cells will be exposed to 8-MOP or angelicin, plant-derived psoralens. Photoactivation of 8-MOP induces ICLs and monoadducts, whereas angelicin produces only monoadducts...
  6. The contribution of DNA interstrand crosslinks to aging
    Laura Niedernhofer; Fiscal Year: 2009
    ..ERCCl-XPF-deficient cells will be exposed to 8-MOP or angelicin, plant-derived psoralens. Photoactivation of 8-MOP induces ICLs and monoadducts, whereas angelicin produces only monoadducts...
  7. The contribution of DNA interstrand crosslinks to aging
    LAURA JANE NIEDERNHOFER; Fiscal Year: 2010
    ..ERCCl-XPF-deficient cells will be exposed to 8-MOP or angelicin, plant-derived psoralens. Photoactivation of 8-MOP induces ICLs and monoadducts, whereas angelicin produces only monoadducts...
  8. The contribution of DNA interstrand crosslinks to aging
    LAURA JANE NIEDERNHOFER; Fiscal Year: 2010
    ..ERCCl-XPF-deficient cells will be exposed to 8-MOP or angelicin, plant-derived psoralens. Photoactivation of 8-MOP induces ICLs and monoadducts, whereas angelicin produces only monoadducts...
  9. CHARACTERIZATION OF PSORALEN DNA PHOTOADDUCTS
    FRANCIS GASPARRO; Fiscal Year: 1990
    ..Three psoralens (8-methoxypsoralen, 4'-aminomethyl-4,5',8-trimethylpsoralen, and 4',5-dimethylangelicin) will be used in ..
  10. Mechanisms of Psoralen-Induced Reproductive Toxicity
    MOUSSA DIAWARA; Fiscal Year: 2002
    The psoralens are naturally occurring plant metabolites found in common fruit and vegetable crops...
  11. ACTION SPECTRA AND BIOCHEMISTRY OF PHOTODERMATOSES
    Derek Cripps; Fiscal Year: 1980
    ..More recently the investigator has reevaluated the action spectra of topical psoralens (P) which showed maximum sensitivity at 330-335 nm...
  12. SINGLET OXYGEN REACTIONS WITH ORGANIC SUBSTRATES
    HARRY WASSERMAN; Fiscal Year: 1980
    ..In addition, studies on benzofurans related to the psoralens will be continued in order to determine correlations between reactivity with singlet oxygen and biological ..
  13. PHOTOTOXICITY OF ENVIRONMENTAL CHEMICALS
    JEFFREY LASKIN; Fiscal Year: 1990
    Cutaneous chemical phototoxicity is the response of the skin to the combined effects of a chemical and sunlight. Psoralens such as xanthotoxin (8-methoxypsoralen or 8-MOP) and bergaptan (5- methoxypsoralen) are among the most commonly ..
  14. REPLICATION AND REPAIR OF GENETIC MATERIAL
    Philip Hanawalt; Fiscal Year: 1990
    ..will be used to analyze genomic distribution of bulky adducts produced by N-acetoxyacetylaminofluorene and the psoralens. A sensitive assay based upon renaturability of DNA will be used to monitor introduction and repair of psoralen ..
  15. CELL RESPONSE TO DNA DAMAGE BY UV AND OTHER MUTAGENS
    D Carter; Fiscal Year: 1980
    ..We are also measuring concentrations of psoralens in blood of our PUVA patients and correlating these values with the patients' phototoxic and therapeutic ..
  16. NUCLEIC ACID INTERACTIONS WITH SYNTHETIC PSORALENS
    JOHN HEARST; Fiscal Year: 1980
    The monoadducts and crosslinks formed by photochemical cycloaddition of psoralens to DNA are isolated by enzymatic digestion of DNA after reaction with psoralens...
  17. DECONTAMINATION OF PLATELET CONCENTRATES
    Lily Lin; Fiscal Year: 1993
    ..Although psoralens are highly specific for nucleic acid inactivation, the prototype technique is of limited utility due to ..
  18. MELANOMA DELINEATING RADIOPHARMACEUTICALS
    Ned Heindel; Fiscal Year: 1980
    Several families of potentially melanophilic radiopharmaceuticals (based on quinolines, psoralens, and melatonin) have been proposed for synthesis, in vitro melanin binding studies, and tumor uptake measurements in animal melanoma models...
  19. Listeria-CEA Vaccine-Infected DC for Cancer Therapy
    Dirk Brockstedt; Fiscal Year: 2004
    ..We have also engineered Listeria to be exquisitely sensitive to inactivation by psoralens, a group of compounds that form irreversible cross-links in the genomes of bacteria after illumination with ..
  20. VITILIGO CENTER GRANT
    Aaron Lerner; Fiscal Year: 1980
    ..We have developed a method to quantify Langerhan cells in epidermal sheets. Psoralens and UVA (320 - 400 nm) deplete the skin of Langerhan cells but not short wave ultraviolet light(250-320nm).
  21. CELL DIVISION STUDIED BY LASER
    Michael Berns; Fiscal Year: 1980
    ..laser wavelengths in combination with the treatment of light-sensitive compounds, such as acridine orange, BrdU, psoralens. The structure and function of the centriolar region will then be studied by time lapse analysis, electron ..
  22. FLEXIBILITY OF DNA
    Paul Hagerman; Fiscal Year: 1990
    ..of the magnitude of the distortion of the helix axis which results from the interstrand cross-linking of DNA by psoralens. Finally, we intend to continue our studies of the geometry of four-way DNA junctions, thought to be ..
  23. TARGETED DNA REPAIR OF PSORALEN ADDUCTS IN SKIN CELLS
    Dennis Oh; Fiscal Year: 2000
    This project focuses on DNA repair of sequence-specific damage caused by psoralens linked to antigene oligonucleotides (pso-AGOs) in human skin cells...
  24. TARGETED DNA REPAIR OF PSORALEN ADDUCTS IN SKIN CELLS
    Dennis Oh; Fiscal Year: 2000
    This project focuses on DNA repair of sequence-specific damage caused by psoralens linked to antigene oligonucleotides (pso-AGOs) in human skin cells...
  25. TARGETED DNA REPAIR OF PSORALEN ADDUCTS IN SKIN CELLS
    Dennis Oh; Fiscal Year: 2001
    This project focuses on DNA repair of sequence-specific damage caused by psoralens linked to antigene oligonucleotides (pso-AGOs) in human skin cells...
  26. TARGETED DNA REPAIR OF PSORALEN ADDUCTS IN SKIN CELLS
    Dennis Oh; Fiscal Year: 1999
    This project focuses on DNA repair of sequence-specific damage caused by psoralens linked to antigene oligonucleotides (pso-AGOs) in human skin cells...
  27. LENS PROTEINS & FLUORESCENCE: IN VIVO AND IN VITRO STUDY
    SIDNEY LERMAN; Fiscal Year: 1990
    ..lens, we are continuing our investigations on (UV) photosensitized damage as exemplified by our work on the Psoralens and Allopurinol...
  28. SKIN-SENSITIZING & CARCINOGENIC FUROCOUMARINS
    Pill Soon Song; Fiscal Year: 1980
    ..has been two-fold: (1) Elucidation of the molecular mechanism of photosensitizing potency of furocoumarins (psoralens), and (2) application of psoralens as molecular structural probes for nucleic acids and proteins...
  29. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2002
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  30. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2003
    ....
  31. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 1991
    ..The proposed studies will provide a broad picture of effects of chronic benzodiazepines at the molecular level, together with evaluation of interventions that have direct relevance to prevention of benzodiazepine withdrawal...
  32. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2001
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  33. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2004
    ....
  34. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..The in vitro model, if validated, has the potential to provide clinically important information on interactions involving HIV treatments and abusable drugs, at relatively low cost and with no human drug exposure. ..
  35. MDR1 and Related Proteins during HIV PI Exposure
    David Greenblatt; Fiscal Year: 2005
    ..The findings will be of importance in understanding lipid disorders related to PIs as well as the kinetics of drugs used to treat HIV and related disorders. ..
  36. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2002
    ....
  37. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2004
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  38. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 1992
    ..The proposed studies will provide a broad picture of effects of chronic benzodiazepines at the molecular level, together with evaluation of interventions that have direct relevance to prevention of benzodiazepine withdrawal...
  39. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2001
    ....
  40. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  41. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  42. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  44. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2008
    ..We anticipate that commercialization of the AEGIS will reduce the incidence of incompatible transfusions and thus improve transfusion outcomes and patient safety. ..
  45. Adverse effects of RBC transfusions: A unifying hypothesis
    John D Roback; Fiscal Year: 2010
    ..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
  46. Adverse effects of RBC transfusions: A unifying hypothesis
    John Roback; Fiscal Year: 2009
    ..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
  47. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  48. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2002
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  49. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2003
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  50. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2004
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  51. Mechanisms Underlying Drug-Diet Interactions
    MARY PAINE; Fiscal Year: 2009
    ..The knowledge gained will provide critical information to both clinicians and the lay public as to whether specific dietary substances can be taken safely with certain medications. ..
  52. REGULATION OF P53 STABILITY BY SER315 PHOSPHORYLATION
    Mats Ljungman; Fiscal Year: 2001
    ..We will express wild-type or mutant CDC14 in MCF7 cells and study what effect it will have on basal and induced levels of p53. ..
  53. SICKLE RBC, INTERMITTENT HYPOXIA AND VASCULAR PATHOLOGY
    FRANS KUYPERS; Fiscal Year: 2001
    ..Together, our results may indicate novel treatment regiments in the management of SCD. ..
  54. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  55. SURFACE ANTIGENS OF TREPONEMA PALLIDUM
    Wesley Van Voorhis; Fiscal Year: 1999
    ..pallidum and will identify potential vaccine candidates for further study. ..
  56. SURFACE ANTIGENS OF TREPONEMA PALLIDUM
    Wesley Van Voorhis; Fiscal Year: 2001
    ..pallidum and will identify potential vaccine candidates for further study. ..
  57. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 1999
    ....
  58. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2001
    ....
  59. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2005
    ....
  60. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2005
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  61. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2003
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  62. SURFACE ANTIGENS OF TREPONEMA PALLIDUM
    Wesley Van Voorhis; Fiscal Year: 2000
    ..pallidum and will identify potential vaccine candidates for further study. ..
  63. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  64. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2003
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  65. GARLIC PREPARATIONS AND ANTIRETROVIRAL DRUGS
    David Greenblatt; Fiscal Year: 2002
    ..The work will provide immediately applicable clinical data on garlic interactions with antiretrovirals, as well as mechanistic data identifying the interaction process and its predictability from in vitro models. ..
  66. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2002
    ....
  67. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2006
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  68. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2002
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  69. Mechanisms Underlying Drug-Diet Interactions
    MARY PAINE; Fiscal Year: 2009
    ..The knowledge gained will provide critical information to both clinicians and the lay public as to whether specific dietary substances can be taken safely with certain medications. ..
  70. TRANSFUSION MEDICINE/HEMOSTASIS TRAIL SITE AT PSBC
    Sherrill Slichter; Fiscal Year: 2007
    ..Dana Matthews) at our Childrens Hospital to determine if she is willing to enroll patients in the RICH trial. [unreadable] [unreadable] [unreadable] PUGET SOUND BLOOD CENTER CRITIQUES [unreadable] [unreadable] [unreadable] [unreadable]..
  71. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2003
    ....
  72. SURFACE ANTIGENS OF TREPONEMA PALLIDUM
    Wesley Van Voorhis; Fiscal Year: 2005
    ..Finally, these studies will help define the protective immune response that results after immunization with Tp92 as well as the immune response to Tp92 that occurs during infection. ..
  73. SICKLE RBC, INTERMITTENT HYPOXIA AND VASCULAR PATHOLOGY
    FRANS KUYPERS; Fiscal Year: 2003
    ..Together, our results may indicate novel treatment regiments in the management of SCD. ..
  74. BIOLOGIC AND IMMUNOLOGIC ASPECTS OF TRANSFUSION MEDICINE
    Sherrill Slichter; Fiscal Year: 2007
    ..End of Abstract) ..