benzothiadiazines

Summary

Summary: Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

Top Publications

  1. pmc Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures
    Jin Shun Qi
    Department of Biology, 201 Life Sciences Building, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 577:579-90. 2006
  2. pmc Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo
    Jinshun Qi
    Department of Biology, 201 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 571:605-18. 2006
  3. doi Comparative toxicity of bentazon and molinate on growth, photosynthetic pigments, photosynthesis, and respiration of the Portuguese ricefield cyanobacterium Nostoc muscorum
    Victor Galhano
    Department of Biology and Environmental Engineering Centre for Research and Technology of Agro Environment and Biological Sciences, University of Tras os Montes and Alto Douro, Apartado 1013 5001 801 Vila Real, Portugal
    Environ Toxicol 25:147-56. 2010
  4. pmc BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide
    Yun Wang
    Institutes of Brain Science and State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neuropharmacology 57:49-59. 2009
  5. doi Photocatalytic degradation of bentazone in soil washing wastes containing alkylpolyoxyethylene surfactants
    M Davezza
    Dipartimento di Chimica Analitica, Universita di Torino, 10125 Torino, Italy
    Chemosphere 86:335-40. 2012
  6. doi Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats
    Binbin Qian
    Institutes of Brain Science, State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai 200032, China
    Seizure 20:312-9. 2011
  7. pmc Cyclothiazide induces seizure behavior in freely moving rats
    Shuzhen Kong
    Research Centre of Medicinal Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing, China
    Brain Res 1355:207-13. 2010
  8. doi Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase
    Pamela L Donner
    Antiviral Research, Global Pharmaceutical Research, and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 18:2735-8. 2008
  9. ncbi Determination of two phototransformation products of bentazone using quadrupole time-of-flight mass spectrometry
    Manuela Peschka
    Europa University of Applied Sciences, Limburger Strasse 2, Idstein, Germany
    Anal Bioanal Chem 388:1227-34. 2007
  10. ncbi Induction and inactivation of a cytochrome P450 confering herbicide resistance in wheat seedlings
    N Forthoffer
    , CNRS-UPR 406, , Strasbourg, France
    Eur J Drug Metab Pharmacokinet 26:9-16. 2001

Detail Information

Publications151 found, 100 shown here

  1. pmc Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures
    Jin Shun Qi
    Department of Biology, 201 Life Sciences Building, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 577:579-90. 2006
    ..Thus, in addition to synaptic alteration of GABAergic transmission, regulation of tonic inhibition may also play an important role during epileptogenesis...
  2. pmc Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo
    Jinshun Qi
    Department of Biology, 201 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 571:605-18. 2006
    ..The long-lasting epileptiform activity after CTZ washout may also make it a very useful model in screening antiepileptic drugs...
  3. doi Comparative toxicity of bentazon and molinate on growth, photosynthetic pigments, photosynthesis, and respiration of the Portuguese ricefield cyanobacterium Nostoc muscorum
    Victor Galhano
    Department of Biology and Environmental Engineering Centre for Research and Technology of Agro Environment and Biological Sciences, University of Tras os Montes and Alto Douro, Apartado 1013 5001 801 Vila Real, Portugal
    Environ Toxicol 25:147-56. 2010
    ..5-2 mM). The herbicides had contrasting effects on carbohydrates content: molinate increased this organic fraction whereas bentazon decreased it. Photosynthesis and respiration were inhibited by both herbicides...
  4. pmc BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide
    Yun Wang
    Institutes of Brain Science and State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai 200032, China
    Neuropharmacology 57:49-59. 2009
    ..We conclude that activation of BDNF-TrkB signaling pathway is fundamentally important during the CTZ-induction of epileptiform activity both in vitro and in vivo...
  5. doi Photocatalytic degradation of bentazone in soil washing wastes containing alkylpolyoxyethylene surfactants
    M Davezza
    Dipartimento di Chimica Analitica, Universita di Torino, 10125 Torino, Italy
    Chemosphere 86:335-40. 2012
    ..Useful information about the photocatalytic degradation route was obtained from the HPLC-MS analysis of transient intermediates formed in water...
  6. doi Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats
    Binbin Qian
    Institutes of Brain Science, State Key Laboratory for Medical Neurobiology, Fudan University, Shanghai 200032, China
    Seizure 20:312-9. 2011
    ..The results from this study indicate that hippocampal neurons respond to various convulsant stimulation differently which may reflect the complicated causes of the seizure in clinics...
  7. pmc Cyclothiazide induces seizure behavior in freely moving rats
    Shuzhen Kong
    Research Centre of Medicinal Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing, China
    Brain Res 1355:207-13. 2010
    ..Since CTZ acts on both GABAergic and glutamatergic systems, this new animal epilepsy model will be useful for anticonvulsant drug testing and general epilepsy research...
  8. doi Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase
    Pamela L Donner
    Antiviral Research, Global Pharmaceutical Research, and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 18:2735-8. 2008
    ..We observed that small aromatic rings and alkenyl groups appended to the 5-position of the B-ring were optimal, resulting in inhibitors with low nanomolar potencies...
  9. ncbi Determination of two phototransformation products of bentazone using quadrupole time-of-flight mass spectrometry
    Manuela Peschka
    Europa University of Applied Sciences, Limburger Strasse 2, Idstein, Germany
    Anal Bioanal Chem 388:1227-34. 2007
    ..The required irradiation time was matrix dependent. 2-(Isopropylcarbamoyl)phenylsulfamic acid was detected in a drainage channel in the Ebro river delta (Catalonia, Spain)...
  10. ncbi Induction and inactivation of a cytochrome P450 confering herbicide resistance in wheat seedlings
    N Forthoffer
    , CNRS-UPR 406, , Strasbourg, France
    Eur J Drug Metab Pharmacokinet 26:9-16. 2001
    ..This increased capacity of wheat to detoxify the herbicide through the induction of P450 enzymes seems to be for a large extend the mechanism which confers a tolerance on various herbicides...
  11. ncbi Map-based cloning of a novel rice cytochrome P450 gene CYP81A6 that confers resistance to two different classes of herbicides
    Gang Pan
    College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310029, Zhejiang, China
    Plant Mol Biol 61:933-43. 2006
    ..Based on these results we conclude that the novel cytochrome P450 monooxygenase CYP81A6 encoded by Bel confers resistance to two different classes of herbicides...
  12. doi Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability
    Nicolas Charrier
    Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Park, Harlow, Essex, UK
    J Med Chem 51:3313-7. 2008
    ..Optimization of a first generation of BACE-1 inhibitors led to the discovery of novel hydroxyethylamines (HEAs) bearing a tricyclic nonprime side. These derivatives have nanomolar cell potency and are orally bioavailable...
  13. ncbi BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism
    Karen E Cosgrove
    Department of Biomedical Science, Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    J Clin Endocrinol Metab 87:4860-8. 2002
    ..These data suggest that BPDZ 154 or BPDZ 154-like compounds may have therapeutic potential in the treatment of certain forms of hyperinsulinism...
  14. pmc Cyclothiazide: a subunit-specific inhibitor of GABAC receptors
    An Xie
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W Taylor Street, Chicago, IL 60612, USA
    J Physiol 586:2743-52. 2008
    ..4 s, but the kinetics were approximately 10-fold slower when GABA is absent. The ability of CTZ to interact with various types of neurotransmitter receptors indicates that the drug has multiple actions in the CNS...
  15. doi Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase
    Antony N Shaw
    Department of Medicinal Chemistry, GlaxoSmithKline, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 19:4350-3. 2009
    ..Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative...
  16. pmc Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides
    Licia Tomei
    Department of Biochemistry, Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Pomezia, Italy
    J Virol 78:938-46. 2004
    ..The mutations (M414T, C451R, G558R, and H95R) render the HCV replicons resistant to inhibition by benzothiadiazines, though the mutant replicons remain sensitive to inhibition by other nucleoside and NNIs of the HCV RNA ..
  17. pmc Rational Prescribing in Primary Care (RaPP-trial). A randomised trial of a tailored intervention to improve prescribing of antihypertensive and cholesterol-lowering drugs in general practice [ISRCTN48751230]
    Atle Fretheim
    Department of Health Services Research, Norwegian Directorate for Health and Social Affairs, N 0031 Oslo, Norway
    BMC Health Serv Res 3:5. 2003
    ....
  18. ncbi Influences of educational interventions and adverse news about calcium-channel blockers on first-line prescribing of antihypertensive drugs to elderly people in British Columbia
    M Maclure
    PharmaCare, British Columbia Ministry of Health, Victoria, Canada
    Lancet 352:943-8. 1998
    ....
  19. pmc The potential savings of using thiazides as the first choice antihypertensive drug: cost-minimisation analysis
    Atle Fretheim
    Department of Health Services Research, Norwegian Directorate for Health and Social Affairs, N 0031 Oslo, Norway
    BMC Health Serv Res 3:18. 2003
    ..Despite this, the use of thiazides is much lower than that of other drug-classes. We wanted to estimate the potential for savings if thiazides were used as the first choice drug for the management of uncomplicated hypertension...
  20. pmc Choosing a first-line drug in the management of elevated blood pressure: what is the evidence? 1: Thiazide diuretics
    J M Wright
    Department of Medicine, University of British Columbia, Vancouver
    CMAJ 163:57-60. 2000
    ..The evidence indicates that low-dose thiazides are preferable to high-dose thiazides and that low-dose thiazides are better than or equivalent to other antihypertensive drugs for each of the goals of therapy...
  21. ncbi Changes in the phamacologic treatment of hypertension in the Department of Veterans Affairs 1997-1999: decreased use of calcium antagonists and increased use of beta-blockers and thiazide diuretics
    D Siegel
    Medical Service, Department of Veterans Affairs, Northern California Health Care System, Mather 95655, USA
    Am J Hypertens 14:957-62. 2001
    ..These changes were consistent with improved compliance with VA national guidelines. The cost implications of these changes in practice patterns were considerable...
  22. ncbi Treating high blood pressure in Africans with type 2 diabetes
    E O Okoro
    Ethn Dis 14:160-1. 2004
  23. ncbi Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists
    Chris L Bryson
    VA Puget Sound Health Services Research and Development, VAMC, Seattle, Washington 98108, USA
    J Am Geriatr Soc 52:1648-54. 2004
    ....
  24. ncbi [Recent intervention studies with antihypertensive drugs and their influence on guidelines]
    Karl Heinz Rahn
    Medizinische Klinik und Poliklinik D, Universitatsklinikum, Muenster
    Med Klin (Munich) 98:771-5. 2003
    ..Both groups of experts emphasize that the main benefits of antihypertensive therapy are due to decreasing blood pressure per se...
  25. ncbi [Diabetes and drug treatment of hypertension]
    Andrea Siebenhofer
    Diabetes und Stoffwechselambulanz, Medizinische Universitätsklinik Graz, Auenbruggerplatz 15, 8036 Graz, Osterreich
    Wien Med Wochenschr 153:464-8. 2003
    ..To achieve an effective blood pressure reduction, a combination of different antihypertensive agents is necessary for most patients. Specially structured patient education programmes are another effective means of achieving this goal...
  26. ncbi The return on INVEST
    Michael H Alderman
    JAMA 290:2859-61. 2003
  27. ncbi [Modern strategies of infarction prevention in hypertensives and diabetics. Salt and sugar -- both are risky for the heart]
    Sonja Böhm
    MMW Fortschr Med 145:10. 2003
  28. ncbi Comparison of candesartan with lisinopril on ambulatory blood pressure and morning surge in patients with systemic hypertension
    Kazuo Eguchi
    Department of Cardiology, Jichi Medical School, Tochigi, Japan
    Am J Cardiol 92:621-4. 2003
    ....
  29. ncbi [ALLHAT=other leading physicians have alternative interpretations]
    Alan Charles
    Lakartidningen 100:2073-4. 2003
  30. ncbi Distinguishing between presynaptic and postsynaptic mechanisms of short-term depression during action potential trains
    Adrian Y C Wong
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom
    J Neurosci 23:4868-77. 2003
    ....
  31. ncbi The ANBP2 and ALLHAT: conflicting or consistent?
    Jeffrey A Cutler
    National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7936, USA
    J Clin Hypertens (Greenwich) 5:192-5. 2003
  32. ncbi [Tax payers have payed billions for the "blood pressure maffia's" actions]
    Bengt Järhult
    Lakartidningen 100:1917-8. 2003
  33. ncbi Shifting trends in the pharmacologic treatment of hypertension in a Nigerian tertiary hospital: a real-world evaluation of the efficacy, safety, rationality and pharmaco-economics of old and newer antihypertensive drugs
    A Q Adigun
    Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, USA
    J Hum Hypertens 17:277-85. 2003
    ....
  34. ncbi Properties of quantal transmission at CA1 synapses
    Sridhar Raghavachari
    Dept of Biology and Volen Center for Complex Systems, Brandeis University MS 008, 415 South S, Waltham, MA 02454, USA
    J Neurophysiol 92:2456-67. 2004
    ....
  35. ncbi [Revival of antihypertensive therapy: use of thiazide diuretics]
    Viktor Nagy
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászai Klinika, Budapest
    Orv Hetil 145:669-76. 2004
    ..The newer diuretics--with fewer side effects--have very likely extrarenal way of effects, so their long time application seems very favourable...
  36. ncbi [ALLHAT trial--antithesis to the overuse of vasodilating antihypertensive drugs]
    Iwao Kuwajima
    Division of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
    Nihon Rinsho 62:648-53. 2004
  37. ncbi Cyclothiazide prolongs low [Mg2+]-induced seizure-like events
    Bálint Lasztóczi
    Department of Neurochemistry, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri ut 59 67, Budapest H 1025, Hungary
    J Neurophysiol 96:3538-44. 2006
    ..In contrast, the self-similar slow-down of low [Mg(2+)]-induced SLE dynamics by CTZ indicate AMPA receptor desensitization as a parameter shaping SLEs...
  38. ncbi [Comrades! There must be some blood order in the field of hypertension!]
    Arne Melander
    NEPI, Malmö och Stockholm
    Lakartidningen 102:1068-70. 2005
  39. ncbi Quality of life and antihypertensive drug therapy
    Joel Handler
    Kaiser Permanente, Anaheim, CA 92807, USA
    J Clin Hypertens (Greenwich) 7:274-85. 2005
    ..Medication compliance requires a multi-tiered strategy. Low-dose thiazide is well tolerated...
  40. ncbi C-terminal truncation affects kinetic properties of GluR1 receptors
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, MC 9629, 801 N Rutledge, Room 3275, Springfield, IL 62702, USA
    Mol Cell Neurosci 29:1-10. 2005
    ..The lowered affinity and faster inactivation of these receptors suggests that their presence does not represent a risk for neuronal viability...
  41. ncbi Clinical inquiries. What is the best regimen for newly diagnosed hypertension?
    Joseph J Saseen
    University of Colorado Health Sciences Center, University of Colorado Family Medicine Residency Program, 4200 E 9th Ave Box C238, Denver, CO 80218 USA
    J Fam Pract 54:281-2. 2005
  42. ncbi Diuretics for cardiovascular prevention in the elderly
    O Hanon
    Department of Geriatrics, Hopital Broca, rue Pascal, Paris, France
    J Hum Hypertens 18:S15-22. 2004
    ....
  43. ncbi Angiotensin-converting enzyme inhibitors and diuretics: optimal combination therapy
    Mori J Krantz
    Ann Intern Med 141:893; author reply 893. 2004
  44. ncbi [Thiaside diuretics in combination with inhibitors of angiotensin-converting enzyme in patients with diabetes mellitus type 2 comorbid with arterial hypertension]
    I E Chazova
    Ter Arkh 76:28-32. 2004
    ....
  45. ncbi Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohort
    Raj Padwal
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Diabetes Care 27:2458-63. 2004
    ..The aim of this study was to determine whether the incidence of type 2 diabetes differed among elderly users of four major antihypertensive drug classes...
  46. ncbi Use of beta-blockers and risk of fractures
    Raymond G Schlienger
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
    JAMA 292:1326-32. 2004
    ....
  47. pmc Improving prescribing of antihypertensive and cholesterol-lowering drugs: a method for identifying and addressing barriers to change
    Atle Fretheim
    Informed Choice Research Department, Norwegian Health Services Research Centre, P, O, Box 7004, St, Olavs plass, Oslo, Norway
    BMC Health Serv Res 4:23. 2004
    ..We also report the results of a post hoc exercise and survey we carried out to evaluate our approach for identifying barriers and tailoring interventions...
  48. ncbi Following evidence-based prescribing guidelines for antihypertensives could save big bucks
    Gina Rollins
    Rep Med Guidel Outcomes Res 15:1, 6-7. 2004
  49. ncbi [Thiazides or ACE inhibitors? A drug-economic analysis]
    Ivar Aursnes
    Tidsskr Nor Laegeforen 124:1668. 2004
  50. ncbi [Risk factors to be considered at the beginning of antihypertensive therapy in diabetes mellitus]
    Gyorgy Jermendy
    Bajcsy Zsilinszky Kórház III Belgyógyászati Osztály, Budapest
    Orv Hetil 145:949-56. 2004
    ..It is reasonable to initiate antihypertensive therapy primarily with a low dose combination of two agents in diabetic patients with hypertension...
  51. ncbi ALLHAT: a critical assessment
    Ake Sjoholm
    Karolinska Institutet, Internal Medicine, South Stockholm General Hospital, Stockholm, Sweden
    Blood Press 13:75-9. 2004
    ..Thus, the ALLHAT study suffers from several major shortcomings and there is a huge body of evidence that contradicts the ALLHAT interpretations...
  52. pmc Relative roles of different mechanisms of depression at the mouse endbulb of Held
    Hua Yang
    University of Buffalo, Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA
    J Neurophysiol 99:2510-21. 2008
    ..Furthermore, calcium-dependent recovery at the endbulb is critical to prevent complete rundown during high activity and to preserve the reliability of information transmission...
  53. ncbi Long-term potentiation alters the modulator pharmacology of AMPA-type glutamate receptors
    Bin Lin
    Department of Psychiatry, University of California, Irvine, California 92697, USA
    J Neurophysiol 87:2790-800. 2002
    ..Candidates for the changes responsible for the observed effects of LTP were evaluated using a model of AMPA receptor kinetics; a simple increase in the channel opening rate provided the most satisfactory match with the LTP data...
  54. ncbi [Consequences of ALLHAT: Thiazides rehabilitated--time to change prescription patterns]
    Anders Hernborg
    Avdelningen för medicin, Universitetssjukhuset MAS, Malmo
    Lakartidningen 100:408-10. 2003
  55. ncbi Fixed dose combination therapy in the treatment of hypertension
    T Stanton
    Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK
    J Hum Hypertens 16:75-8. 2002
  56. ncbi The thiazide-sensitive na-cl cotransporter and human disease: reemergence of an old player
    David H Ellison
    J Am Soc Nephrol 14:538-40. 2003
  57. ncbi [Policy of antihypertensive therapy in arterial hypertension in the elderly. II]
    M A Gurevich
    Klin Med (Mosk) 80:9-13. 2002
  58. ncbi [Reflexion of French experts on the key points of the symposium]
    J M Mallion
    Presse Med 31:S27-30. 2002
    ..Professor O. Dubourg recalled the beneficial effect of indapamid SR on LVH demonstrated in the LIVE study. Likewise, Professor M. Marre emphasized its important impact on microalbuminuria as shown in the NESTOR study...
  59. ncbi Blocking AMPA receptor desensitization prolongs spontaneous EPSC decay times and depolarizes H1 horizontal cells in carp retinal slices
    H Hirasawa
    Supermolecular Division, Electrotechnical Laboratory, Tsukuba, Ibaraki 305-8568, Japan
    Neurosci Res 40:217-25. 2001
    ..The desensitization of glutamate receptors may function to extend the dynamic range of H1 HC light responses...
  60. ncbi Hypertension: treatment--now & tomorrow
    Chike M Nzerue
    Ethn Dis 12:S2-43-5. 2002
  61. ncbi Activity-dependent change in AMPA receptor properties in cerebellar stellate cells
    Siqiong June Liu
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:3881-9. 2002
    ..The activity-induced expression of GluR2-containing receptors significantly reduced the Ca(2+) permeability of AMPARs in stellate cells but did not slow the decay time course of synaptic currents...
  62. ncbi Effect of 14 years of antihypertensive treatment on renal function and urinary albumin excretion in primary hypertension
    A Siewert-Delle
    Department of Nephrology, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Am J Hypertens 9:841-9. 1996
    ..The increase in RVR and the decrease in RBF seen during 14 years of antihypertensive treatment was of the same magnitude as that seen with normal aging...
  63. ncbi Prescribing patterns and therapeutic implications for diabetic hypertension in Bahrain
    K A Al Khaja
    Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain
    Ann Pharmacother 35:1350-9. 2001
    ..To determine drug prescription patterns and the extent of conformity with World Health Organization/international Society of Hypertension (WHO/ISH) guidelines in diabetic hypertension...
  64. ncbi [Established blood pressure drug wins out in a comparative study. In hypertension, a diuretic first!]
    Ulrike Wepner
    MMW Fortschr Med 145:10-2. 2003
  65. ncbi Correlation of AMPA receptor subunit composition with synaptic input in the mammalian cochlear nuclei
    S M Gardner
    Department of Physiology, University of Wisconsin Medical School-Madison, Madison, Wisconsin 53706, USA
    J Neurosci 21:7428-37. 2001
    ....
  66. ncbi AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure
    Shu Huei Hsiao
    Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine MS 1114, College Station, TX 77843 1114, USA
    Brain Res Dev Brain Res 142:89-99. 2003
    ..Repeating this inhibition during early postnatal binge-like intoxication can augment normal development of AMPAR function...
  67. ncbi Hypertension, anti-hypertensive drug therapy and erectile dysfunction in diabetes
    P K Moulik
    Department of Medicine, Whiston Hospital, Prescot, UK
    Diabet Med 20:290-3. 2003
    ..The risk factors for ED were studied with particular reference to hypertension and anti-hypertensive drugs...
  68. ncbi Treatment of hypertension in type 2 diabetes mellitus: blood pressure goals, choice of agents, and setting priorities in diabetes care
    Sandeep Vijan
    Veterans Affairs Health Services Research, Development Center for Practice Management and Outcomes Research, P O Box 130170, Ann Arbor, Michigan 48113 0170, USA
    Ann Intern Med 138:593-602. 2003
    ..Hypertension in patients with type 2 diabetes mellitus is a prevalent condition that leads to substantial morbidity and mortality...
  69. ncbi The evidence base for tight blood pressure control in the management of type 2 diabetes mellitus
    Vincenza Snow
    American College of Physicians, 190 N Independence Mall West, Philadelphia, Pennsylvannia 19106, USA
    Ann Intern Med 138:587-92. 2003
  70. ncbi Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides
    Claudiu T Supuran
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Curr Pharm Des 14:641-8. 2008
    The widely clinically used benzothiadiazines and high ceiling diuretics, such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide, contain SO(2)NH(2) moieties acting ..
  71. ncbi ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives
    Hai Wang
    Department of Cardiovascularl Pharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, Peoples Republic of China
    Curr Med Chem 14:133-55. 2007
    ..2) cyanoguanidines, (3) thioformamides, (4) pyrimidine derivatives, (5) pyridine derivatives, (6) benzothiadiazines, (7) dihydropyridines, (8) nicotinamide derivatives, and (9) aliphatic amines...
  72. ncbi Studies of benzothiadiazine derivatives as hepatitis C virus NS5B polymerase inhibitors using 3D-QSAR, molecular docking and molecular dynamics
    X Wang
    Center of Bioinformatics, Northwest A and F University, Yangling, Shaanxi, China
    Curr Med Chem 17:2788-803. 2010
    ..with similar size of benzo group like isosteres are preferential at positions 1 and 2 (ring B of benzothiadiazines)...
  73. ncbi Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors
    J W Corbett
    DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880 0500, USA
    Bioorg Med Chem Lett 10:193-5. 2000
    ..The 2,2-dioxide-1H-2,1,3-benzothiadiazine ring system was constructed in one step from 2-amino-5-chlorobenzonitrile...
  74. ncbi A continuous high frequency stimulation of the subthalamic nucleus determines a suppression of excitatory synaptic transmission in nigral dopaminergic neurons recorded in vitro
    Ada Ledonne
    Universita degli Studi di Roma Tor Vergata, Rome, Italy
    Exp Neurol 233:292-302. 2012
    ..The deficit of transmission between the STN and the SNpc could have a role in the therapeutic effects of the DBS procedure...
  75. ncbi [Synthesis, physicochemical and pharmacological properties of pentacyclic alkaloid-analogues]
    Máté Bubenyák
    Semmelweis Egyetem Gyógyszerészi Kémiai Intézet 1092 Bp Hogyes Endre u 9
    Acta Pharm Hung 81:139-49. 2011
    ..attributes of the synthesized intermediaries were defined, such as the pKa constants of 2,3-poly-methylene-benzothiadiazines. Proton/deuteron exchange kinetic constants of active methylene-groups of five tricyclic compounds were ..
  76. pmc Sodium disorders in the elderly
    Naureen Tareen
    Department of Medicine at the West Los Angeles, Veteran Administration Medical Center, CA, USA
    J Natl Med Assoc 97:217-24. 2005
    ..In this update, we have summarized age-related homeostatic changes that impair sodium balance, medications that alter salt and water handling, and the recognition and management of sodium disorders in elderly patients...
  77. pmc Mechanisms underlying presynaptic facilitatory effect of cyclothiazide at the calyx of Held of juvenile rats
    T Ishikawa
    Department of Neurophysiology, University of Tokyo, Faculty of Medicine, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
    J Physiol 533:423-31. 2001
    ..6. We conclude that CTZ facilitates transmitter release through suppression of presynaptic potassium conductance and stimulation of exocytotic machinery downstream of Ca(2+) influx...
  78. ncbi AMPA receptor desensitization as a determinant of vulnerability to focally evoked status epilepticus
    Francesco Fornai
    Department of Pharmacology, W215 Research Bldg, 3970 Reservoir Road NW, Georgetown University, Washington, DC 20057, USA
    Eur J Neurosci 21:455-63. 2005
    ....
  79. pmc Paired-pulse depression at photoreceptor synapses
    Katalin Rabl
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198 5840, USA
    J Neurosci 26:2555-63. 2006
    ..Thus, depression of release is not likely to contribute to differences in the kinetics of transmission from rods and cones...
  80. ncbi Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites--analysis of glass transition composition relationships
    Lidia Tajber
    School of Pharmacy, The University of Dublin, Trinity College, Dublin 2, Ireland
    Eur J Pharm Sci 24:553-63. 2005
    ..The Schneider equation may be successfully applied to fit the Tg-composition profiles obtained, where other models fail to give good predictions...
  81. ncbi 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase
    Rosanna Tedesco
    Department of Medicinal Chemistry and Drug Metabolism, The Musculoskeletal, Microbial and Proliferative Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, Collegeville, PA 19426, USA
    J Med Chem 49:971-83. 2006
    ..The potential for development and safety assessment profile of compound 130 will also be discussed...
  82. ncbi Laboratory degradation studies of bentazone, dichlorprop, MCPA, and propiconazole in Norwegian soils
    C W Thorstensen
    The Norwegian Crop Research Institute, Plant Protection, As, Norway
    J Environ Qual 30:947-53. 2001
    ..Pesticide degradation was approximated to first-order kinetics. Slow rates of degradation, where more than 50% of the pesticide remained in the soil after the 84-d duration of the experiment, did not fit well with first-order kinetics...
  83. ncbi Determination of bentazone, dichlorprop, and MCPA in different soils by sodium hydroxide extraction in combination with solid-phase preconcentration
    C W Thorstensen
    The Norwegian Crop Research Institute, Plant Protection, Høgskoleveien 7, N 1432 As, Norway
    J Agric Food Chem 49:4199-202. 2001
    ..4 (Hole), 2.5 (Kroer), and 37.8% (Froland) organic carbon, respectively. Limits of quantification using GC-MS were 0.0003 microg/g of wet soil for bentazone and 0.0001 microg/g of wet soil for both dichlorprop and MCPA...
  84. ncbi Combination therapy in the management of hypertension: focus on angiotensin receptor blockers combined with diuretics
    Paolo Palatini
    University of Padova, Padova, Italy
    J Clin Hypertens (Greenwich) 7:96-101. 2005
    ..Recent studies have shown that angiotensin II receptor blockers, given alone or combined with a diuretic, may prevent some cardiovascular outcomes independent of their blood pressure-lowering efficacy...
  85. ncbi LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons
    P Baumbarger
    Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company, Indianapolis, IN 46285-0510, USA
    Neuropharmacology 40:992-1002. 2001
    ..Spontaneous activity of PFC neurons was also increased. Collectively, these results demonstrate that LY392098 is a highly potent, selective and centrally active positive modulator of native AMPA receptors...
  86. ncbi Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons
    S Lei
    Departments of Physiology and Pharmacology and Anaesthesia, University of Toronto, Toronto M5S 1A8, Ontario K7L 3N6, Canada
    J Neurophysiol 85:2030-8. 2001
    ..These results demonstrate that a reduction in the proton sensitivity of receptor desensitization contributes to the mechanism of action of some positive modulators of AMPA receptors...
  87. ncbi Simultaneous determination of enantiomerization and hydrolysis kinetic parameters of chiral N-alkylbenzothiadiazine derivatives
    Marina M Carrozzo
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy
    Chirality 22:389-97. 2010
    ..Hydrolysis rates are quite similar for the two benzothiadiazines methyl substituted to nitrogen at 2- and 4-positions...
  88. ncbi Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome
    K Takeuchi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 81:4496-9. 1996
    ....
  89. ncbi Role of non-NMDA receptors in osmotic and glutamate stimulation of vasopressin release: effect of rapid receptor desensitization
    C D Sladek
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, IL 60064, USA
    J Neuroendocrinol 10:897-903. 1998
    ..These results support a role for non-NMDA receptor activation in osmotic regulation of VP release...
  90. pmc Satellite NG2 progenitor cells share common glutamatergic inputs with associated interneurons in the mouse dentate gyrus
    Jean Marie Mangin
    Department of Neurology, Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 28:7610-23. 2008
    ..The finding that NG2(+) cells are sensing patterns of activity arising in closely associated neurons suggests that NG2(+) cell function is finely regulated by the local network...
  91. ncbi In silico studies of urease inhibitors to explore ligand-enzyme interactions
    Farzana Latif Ansari
    Department of Chemistry, Quaid i Azam University, Islamabad, 45320, Pakistan
    J Enzyme Inhib Med Chem 24:151-6. 2009
    ..This may be ascribed mainly to the difference in the orientation of ring B of the two stereoisomers and the extent of their interaction with Asp224 and Cys322 present in the catalytic core of the enzyme...
  92. ncbi Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats
    C Lebrun
    Division of Cerebral Pathology, Institut de Recherches Servier, 125, Chemin de Ronde, 78290 Croissy sur Seine, France
    Eur J Pharmacol 401:205-12. 2000
    ..Furthermore, S 18986-1 was long-acting and demonstrated a good oral bioavailability. These data confer on S 18986-1, a potential role in improving episodic memory impaired in neurodegenerative diseases and during aging...
  93. ncbi Is there a preferred antihypertensive therapy for isolated systolic hypertension and reduced arterial compliance?
    S S Franklin
    UCI Heart Disease Prevention Program, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
    Curr Hypertens Rep 2:253-9. 2000
    ....
  94. ncbi Chronic magnesium administration enhances oxidative glucose metabolism in thiazide treated hypertensive patients
    G Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, 1st Medical School, University of Naples, Italy
    Am J Hypertens 5:681-6. 1992
    ..In the multiple linear regression analysis of the pooled basal data (n = 42), erythrocyte magnesium content displayed an independent correlation with basal plasma insulin levels (t = -2.08, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)..
  95. ncbi Efficacy and safety of cilazapril, a new angiotensin-converting enzyme inhibitor
    R C Goldszer
    Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts
    Am J Hypertens 1:300S-302S. 1988
    ..There was no change in standing or sitting heart rate, white blood cell count, creatinine clearance, urine protein levels. This is the first long-term data on this new converting enzyme inhibitor in human beings...
  96. ncbi Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling
    Atsushi Kohjitani
    Section on Steroid Regulation, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Neurosci Lett 430:75-80. 2008
    ..These findings suggest that expression of SULT2B1a, which catalyzes PREGS production, is inhibited by activation of excitatory amino acid receptors of the AMPA subtype, via facilitation of intracellular NO signaling...
  97. pmc Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model
    Chih Ming Chen
    Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA
    Antimicrob Agents Chemother 51:4290-6. 2007
    ..These findings validate the antiviral efficacy and resistance development of benzothiadiazine HCV polymerase inhibitors in vivo...
  98. pmc Targeting AMPA receptor gating processes with allosteric modulators and mutations
    Nicholas A Mitchell
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Biophys J 92:2392-402. 2007
    ....
  99. pmc Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists
    Alexander Surin
    Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Neuropharmacology 52:744-54. 2007
    ....
  100. ncbi Studies of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds
    G Cannazza
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy
    Chirality 13:94-101. 2001
    ....
  101. ncbi Angiotensin-converting enzyme inhibitors in the treatment of mild to moderate essential hypertension
    A Salvetti
    Cattedra di Terapia Medica Sistematica, Clinica Medica I, University of Pisa, Italy
    Am J Hypertens 2:94S-99S. 1989
    ..However, although available data suggest that ACEIs can be considered a further advance in the treatment of hypertension, more extensive information is needed to confirm these promising results...

Research Grants98

  1. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2002
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  3. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  4. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2003
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  5. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2004
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  6. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2001
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  7. Reducing Adverse Self-Medication Behaviors in Older Adults with Hypertension
    Patricia Neafsey; Fiscal Year: 2005
    ..Healthcare utilization will be compared between the 2 groups after 52 weeks and a cost-benefit analysis conducted. ..
  8. Seizures & Amydala-Based Socioemotional Dysfunction
    Ludise Malkova; Fiscal Year: 2007
    ..The team is ideally suited to approach the analysis of comorbidity of seizures and autistic-like symptoms evoked from amygdala and to permit a translationally meaningful analysis of the animal data. [unreadable] [unreadable] [unreadable]..
  9. Control of Synaptic Glutamate Release
    Steven Mennerick; Fiscal Year: 2007
    ....
  10. Synaptic Pathways in the Mammalian Retina
    EDMUND TREXLER; Fiscal Year: 2007
    ..abstract_text> ..
  11. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2005
    ..Outcome measures: The risks of developing or dying from CRC, the costs of screening, and the incremental cost-effectiveness of various screening regimens. ..
  12. Synaptic Pathways in the Mammalian Retina
    EDMUND TREXLER; Fiscal Year: 2005
    ..abstract_text> ..
  13. Neural Substrates of Socioemotional Development
    Ludise Malkova; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. Use-dependent intrinsic plasticity in the cerebellum
    David Linden; Fiscal Year: 2007
    ..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
  15. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2007
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  16. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2005
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  17. Synaptic Transmission in the Mammalian Inner Retina
    JOSHUA SINGER; Fiscal Year: 2007
    ..abstract_text> ..
  18. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2005
    ....
  19. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  20. Regulation of thiazide-sensitive NaCl transport
    David Ellison; Fiscal Year: 2006
    ..Although Mendelian forms of hypertension are rare, they help to elucidate mechanisms of blood pressure regulation that almost certainly contribute to the more common essential variety. ..
  21. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  22. Axonal Signaling in the Hippocampus
    Steven Mennerick; Fiscal Year: 2008
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  23. Axonal Signaling in the Hippocampus
    Steven J Mennerick; Fiscal Year: 2010
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  24. Synaptic transmission in the rod pathway of the mammalian retina
    Joshua H Singer; Fiscal Year: 2010
    ..4 are responsible for X-linked incomplete congenital stationary night blindness, understanding the role that these channels play normally in synaptic transmission may provide insight into this disease. ..
  25. Contribution of increased VDR and CaR to Hypercalciuria in the GHS Rat
    David A Bushinsky; Fiscal Year: 2010
    ..These studies will advance research on hypercalciuria and may ultimately lead to improved care of patients with kidney stones. ..
  26. Glutamate Receptor Desensitization and its Modulation
    KATHRYN MCKAY PARTIN; Fiscal Year: 2010
    ..A biophysical approach to study modulation of deactivation and desensitization using drugs that have intrinsically different modes of action may better direct future efforts to design AMPA-selective, cognition-enhancing drugs. ..
  27. Glial-cytokine-neuronal interactions in neuropathic pain
    Han Rong Weng; Fiscal Year: 2009
    ..We hypothesize that activation of glial cells induced by nerve injury results in dysfunction of glial GTs, which leads to abnormal activation of ionotropic glutamate receptors in the spinal dorsal horn and behavioral hypersensitivity. 1 ..
  28. Use-dependent intrinsic plasticity in the cerebellum
    David Linden; Fiscal Year: 2009
    ..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
  29. Control of Synaptic Glutamate Release
    Steven Mennerick; Fiscal Year: 2009
    ....
  30. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2009
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  31. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. Synaptic transmission in the rod pathway of the mammalian retina
    JOSHUA SINGER; Fiscal Year: 2009
    ..4 are responsible for X-linked incomplete congenital stationary night blindness, understanding the role that these channels play normally in synaptic transmission may provide insight into this disease. ..
  33. Axonal Signaling in the Hippocampus
    Steven Mennerick; Fiscal Year: 2009
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  34. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2009
    ..A biophysical approach to study modulation of deactivation and desensitization using drugs that have intrinsically different modes of action may better direct future efforts to design AMPA-selective, cognition-enhancing drugs. ..
  35. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David Linden; Fiscal Year: 2008
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally...
  36. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2008
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  37. Synaptic Pathways in the Mammalian Retina
    EDMUND TREXLER; Fiscal Year: 2008
    ..abstract_text> ..
  38. CRCNS: Biophysical properties of parallel neural circuits serving night vision
    Joshua H Singer; Fiscal Year: 2010
    ..g., at the annual Society for Neuroscience meeting) to bring together researchers working on combined experimental and computational studies of neural circuits. ..
  39. Regulation of thiazide-sensitive NaCl transport
    David Ellison; Fiscal Year: 2005
    ..Although Mendelian forms of hypertension are rare, they help to elucidate mechanisms of blood pressure regulation that almost certainly contribute to the more common essential variety. ..
  40. Hypoglycemia in the Developing Diabetic Brain
    Kelvin Yamada; Fiscal Year: 2005
    ..g., spatial motor, memory, leaning tasks), and finally addressing whether hypoglycemia and diabetes have synergistic injurious effects upon the developing brain. ..
  41. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 2000
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..
  42. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2004
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  43. CLINICAL PHARMACOLOGY OF LOOP DIURETICS
    D Brater; Fiscal Year: 2001
    ..These data will provide insights into the causes and pathophysiology of decompensation in patients with CHF, thus enhancing our understanding of this increasingly prevalent disease and leading to better therapeutic strategies. ..
  44. Control of Synaptic Glutamate Release
    Steven Mennerick; Fiscal Year: 2003
    ..In addition, we expect our results to elucidate details of the mechanisms of action potential coupling to chemical neurotransmission and a possible mechanism of synaptic plasticity. ..
  45. CLINICAL PHARMACOLOGY OF LOOP DIURETICS
    D Brater; Fiscal Year: 2002
    ..These data will provide insights into the causes and pathophysiology of decompensation in patients with CHF, thus enhancing our understanding of this increasingly prevalent disease and leading to better therapeutic strategies. ..
  46. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2001
    ....
  47. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2002
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  48. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2002
    ....
  49. NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEI
    David Linden; Fiscal Year: 2002
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
  50. NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEI
    David Linden; Fiscal Year: 2001
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
  51. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2004
    ..Outcome measures: The risks of developing or dying from CRC, the costs of screening, and the incremental cost-effectiveness of various screening regimens. ..
  52. CLINICAL PHARMACOLOGY OF LOOP DIURETICS
    D Brater; Fiscal Year: 1999
    ..This proposal begins a long-term attempt to unravel these factors with an ultimate goal of designing therapeutic strategies in patients with CHF which decrease the frequency of decompensation. ..
  53. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2004
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
  54. CLINICAL PHARMACOLOGY OF NSAIDS IN THE ELDERLY
    D Brater; Fiscal Year: 1990
    ..This combined approach should yield on the one hand detailed information as to the disposition and effect of NSAIDs in the elderly and on the other hand quantitation of how these effects extrapolate to a large outpatient clinic...
  55. CLINICAL PHARMACOLOGY OF LOOP DIURETICS
    D Brater; Fiscal Year: 2004
    ..These data will provide insights into the causes and pathophysiology of decompensation in patients with CHF, thus enhancing our understanding of this increasingly prevalent disease and leading to better therapeutic strategies. ..
  56. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 1999
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..
  57. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2004
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  58. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2001
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  59. Human genetic variation and ventricular fibrillation resuscitation outcomes
    Thomas Rea; Fiscal Year: 2009
    ..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..
  60. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 2001
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..
  61. Regulation of thiazide-sensitive NaCl transport
    David H Ellison; Fiscal Year: 2010
    ..A large portion of hypertension is related to genetics. This proposal will help unravel genetic contributions to human blood pressure variation, with the goal of finding better treatments, or better preventive maneuvers. ..
  62. Use-dependent intrinsic plasticity in the cerebellum
    David Linden; Fiscal Year: 2008
    ..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
  63. Contribution of increased VDR and CaR to Hypercalciuria in the GHS Rat
    David Bushinsky; Fiscal Year: 2009
    ..These studies will advance research on hypercalciuria and may ultimately lead to improved care of patients with kidney stones. ..
  64. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  65. Glial-cytokine-neuronal interactions in neuropathic pain
    Han Rong Weng; Fiscal Year: 2010
    ..We hypothesize that activation of glial cells induced by nerve injury results in dysfunction of glial GTs, which leads to abnormal activation of ionotropic glutamate receptors in the spinal dorsal horn and behavioral hypersensitivity. 1 ..
  66. Human genetic variation and ventricular fibrillation resuscitation outcomes
    Thomas D Rea; Fiscal Year: 2010
    ..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..
  67. Regulation of thiazide-sensitive NaCl transport
    David Ellison; Fiscal Year: 2008
    ..Although Mendelian forms of hypertension are rare, they help to elucidate mechanisms of blood pressure regulation that almost certainly contribute to the more common essential variety. ..
  68. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2002
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  69. Synaptic transmission in the rod pathway of the mammalian retina
    JOSHUA SINGER; Fiscal Year: 2007
    ..4 are responsible for X-linked incomplete congenital stationary night blindness, understanding the role that these channels play normally in synaptic transmission may provide insight into this disease. ..
  70. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2006
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  71. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2006
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  72. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2006
    ..Outcome measures: The risks of developing or dying from CRC, the costs of screening, and the incremental cost-effectiveness of various screening regimens. ..
  73. Use-dependent intrinsic plasticity in the cerebellum
    David Linden; Fiscal Year: 2006
    ..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
  74. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 2003
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..
  75. NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEI
    David Linden; Fiscal Year: 2004
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
  76. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2005
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. ..
  77. Regulation of thiazide-sensitive NaCl transport
    David Ellison; Fiscal Year: 2004
    ..Although Mendelian forms of hypertension are rare, they help to elucidate mechanisms of blood pressure regulation that almost certainly contribute to the more common essential variety. ..
  78. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2003
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  79. Synaptic transmission in the rod pathway of the mammalian retina
    JOSHUA SINGER; Fiscal Year: 2008
    ..4 are responsible for X-linked incomplete congenital stationary night blindness, understanding the role that these channels play normally in synaptic transmission may provide insight into this disease. ..
  80. LONG TERM POTENTIATION AND DEPRESSION IN THE CEREBELLUM
    David Linden; Fiscal Year: 2002
    ..In addition, these investigations have potential clinical relevance not only for cerebellar motor disorders, but also for disorders of learning and memory generally. ..
  81. Contribution of increased VDR and CaR to Hypercalciuria in the GHS Rat
    David Bushinsky; Fiscal Year: 2008
    ..These studies will advance research on hypercalciuria and may ultimately lead to improved care of patients with kidney stones. ..
  82. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2007
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  83. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David Linden; Fiscal Year: 2007
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally...
  84. Human genetic variation and ventricular fibrillation resuscitation outcomes
    Thomas Rea; Fiscal Year: 2008
    ..Analyses will incorporate standard and novel approaches of genetic association to assess if and how genetic variation influences resuscitation outcome. ..
  85. NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEI
    David Linden; Fiscal Year: 2000
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
  86. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2003
    ....
  87. Glutamate Receptor Desensitization and its Modulation
    KATHRYN PARTIN; Fiscal Year: 2004
    ....
  88. Synaptic Pathways in the Mammalian Retina
    EDMUND TREXLER; Fiscal Year: 2006
    ..abstract_text> ..
  89. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2006
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  90. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 2002
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..
  91. Regulation of thiazide-sensitive NaCl transport
    David Ellison; Fiscal Year: 2007
    ..Although Mendelian forms of hypertension are rare, they help to elucidate mechanisms of blood pressure regulation that almost certainly contribute to the more common essential variety. ..
  92. Reducing Adverse Self-Medication Behaviors in Older Adults with Hypertension
    Patricia Neafsey; Fiscal Year: 2007
    ..Healthcare utilization will be compared between the 2 groups after 52 weeks and a cost-benefit analysis conducted. [unreadable] [unreadable] [unreadable]..
  93. REGULATION OF THIAZIDE SENSITIVE NACL TRANSPORT
    David Ellison; Fiscal Year: 2000
    ..The underlying hypothesis of these experiments is that some Gitelman's mutations impair protein-protein interactions that are crucial for maintenance of transport activity. ..