mebendazole

Summary

Summary: A nematocide in humans and animals. It acts by interfering with the carbohydrate metabolism and associated energy production of the parasite.

Top Publications

  1. ncbi Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics
    A D Dayan
    Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, CH 1211 Geneva 27, Switzerland
    Acta Trop 86:141-59. 2003
  2. ncbi Spinal hydatidosis
    Antonio Herrera
    Service of Orthopaedic and Trauma Surgery, Miguel Servet University Hospital, Zaragoza, Spain
    Spine (Phila Pa 1976) 30:2439-44. 2005
  3. doi Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    JAMA 299:1937-48. 2008
  4. doi Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial
    Stefanie Knopp
    Departments of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:1420-8. 2010
  5. pmc Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice
    Wen Yuan Du
    Division of Parasitology, Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei Pesticide Toxicology Department, Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taichung, Taiwan
    Infect Immun 71:3947-53. 2003
  6. pmc Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial
    Peter Steinmann
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e25003. 2011
  7. doi Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep
    Laura Maté
    Laboratorio de Farmacologia, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, 7000 Tandil, Argentina
    Biochem Pharmacol 76:773-83. 2008
  8. pmc Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR
    Phonepasong Ayé Soukhathammavong
    National Institute of Public Health, Ministry of Health, Vientiane, Lao People s Democratic Republic
    PLoS Negl Trop Dis 6:e1417. 2012
  9. ncbi Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa
    M Sacko
    Institut National de Recherche en Sante Publique INRSP, Service de Parasitologie, Bamako Coura, Mali
    Trans R Soc Trop Med Hyg 93:195-203. 1999
  10. doi Treatment coverage survey after a school-based mass distribution of mebendazole: Kampot Province, Cambodia
    Nicholas Chesnaye
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Acta Trop 118:21-6. 2011

Research Grants

Detail Information

Publications224 found, 100 shown here

  1. ncbi Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics
    A D Dayan
    Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, CH 1211 Geneva 27, Switzerland
    Acta Trop 86:141-59. 2003
    The pharmacokinetics and toxicity of albendazole, mebendazole and praziquantel are extensively reviewed, drawing on original published work and reviews in the open scientific literature and on assessments by international agencies and ..
  2. ncbi Spinal hydatidosis
    Antonio Herrera
    Service of Orthopaedic and Trauma Surgery, Miguel Servet University Hospital, Zaragoza, Spain
    Spine (Phila Pa 1976) 30:2439-44. 2005
    ..Retrospective study...
  3. doi Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    JAMA 299:1937-48. 2008
    ..Preventive chemotherapy is the mainstay of control, but only 4 drugs are available: albendazole, mebendazole, levamisole, and pyrantel pamoate.
  4. doi Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial
    Stefanie Knopp
    Departments of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:1420-8. 2010
    Single-dose albendazole and mebendazole show limited efficacy in the treatment of trichuriasis...
  5. pmc Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice
    Wen Yuan Du
    Division of Parasitology, Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei Pesticide Toxicology Department, Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taichung, Taiwan
    Infect Immun 71:3947-53. 2003
    ..Mice were orally infected with 35 infective larvae. One group of mice were given a single dose of mebendazole (20 mg/kg of body weight) per os at various times and examined at 14 days postinfection (dpi) for worm recovery ..
  6. pmc Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial
    Peter Steinmann
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e25003. 2011
    ..helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of ..
  7. doi Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep
    Laura Maté
    Laboratorio de Farmacologia, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, 7000 Tandil, Argentina
    Biochem Pharmacol 76:773-83. 2008
    ..CBR substrates such as menadione and mebendazole (a non-fluoride analogue of FLBZ), inhibited this liver microsomal enzymatic reaction, which may confirm the ..
  8. pmc Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR
    Phonepasong Ayé Soukhathammavong
    National Institute of Public Health, Ministry of Health, Vientiane, Lao People s Democratic Republic
    PLoS Negl Trop Dis 6:e1417. 2012
    Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections...
  9. ncbi Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa
    M Sacko
    Institut National de Recherche en Sante Publique INRSP, Service de Parasitologie, Bamako Coura, Mali
    Trans R Soc Trop Med Hyg 93:195-203. 1999
    A randomized, placebo-controlled trial of the efficacy of pyrantel (single dose 12.5 mg/kg bodyweight), mebendazole (single 500 mg dose) and albendazole (single 400 mg dose) in the treatment of hookworm infections (Necator americanus) ..
  10. doi Treatment coverage survey after a school-based mass distribution of mebendazole: Kampot Province, Cambodia
    Nicholas Chesnaye
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Acta Trop 118:21-6. 2011
    ..helminth (STH) infections in school age children (SAC, 6-14 years old), Children Without Worms donates mebendazole to 8 countries with high prevalence of STH infections...
  11. ncbi Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis
    Z Kadry
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    Br J Surg 92:1110-6. 2005
    ....
  12. ncbi Population-based case-control study of mebendazole in pregnant women for birth outcomes
    Nandor Acs
    Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
    Congenit Anom (Kyoto) 45:85-8. 2005
    The objectives of the study was to check the embryotoxic-teratogenic and fetotoxic effect of mebendazole (Vermox; Richter, Budapest, Hungary) treatment during pregnancy...
  13. ncbi Effect of single-dose albendazole and single-dose mebendazole on Necator americanus
    P Nontasut
    Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 20:237-42. 1989
    ..Group II, 54 children, received a single dose mebendazole, 600 mg. After treatment, repeated stool examination was performed on Day 14, Day 21 and Day 28...
  14. ncbi Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole
    M Savlík
    Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, CZ 50005 Hradec Kralove, Czech Republic
    Res Vet Sci 83:20-6. 2007
    ..biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared from liver and small intestine of control ..
  15. doi Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda
    Harriet Namwanje
    Vector Control Division, Ministry of Health, P O Box 1661, Kampala, Uganda
    Trans R Soc Trop Med Hyg 105:586-90. 2011
    ..to compare the efficacies of single and double doses of a combination of 400mg albendazole (ALB) and 500mg mebendazole (MBZ) with those of single and double doses of each drug given alone in the treatment of Trichuris trichiura...
  16. ncbi Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability
    L Moreno
    Laboratorio de Farmacologia, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires UNCPBA, Campus Universitario, Tandil, Argentina
    J Vet Pharmacol Ther 27:299-308. 2004
    ..The data on FLBZ pharmacological behaviour presented here contribute to evaluate its potential to be developed as an anthelmintic for broad spectrum parasite control in ruminants...
  17. ncbi [Effectiveness and safety of mebendazole compared to nitazoxanide in the treatment of Giardia lamblia in children]
    R Rodriguez-Garcia
    Servicio de Pediatria, Hospital General de Zona No 32, Instituto Mexicano del Seguro Social, Minatitlán, Veracruz
    Rev Gastroenterol Mex 64:122-6. 1999
    Compare the effectiveness and safety of mebendazole versus nitazoxanide in the treatment of Giardia lamblia in children...
  18. ncbi Spherical crystallization of mebendazole to improve processability
    Smiti Kumar
    Department of Pharmaceutical Technology Formulations, National Institute of Pharmaceutical Education and Research, Nagar, Punjab, India
    Pharm Dev Technol 13:559-68. 2008
    ..The present study was focused on spherical crystallization of an antihelmentic drug - Mebendazole (MBZ) - using spherical agglomeration technique...
  19. ncbi Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis
    M Legesse
    Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    East Afr Med J 81:134-8. 2004
    ..the comparative efficacy of 400 mg albendazole (Smith Kline Beecham) as a single dose and three brands of mebendazole (Janssen, Unibios and East African Pharmaceuticals) at doses of 100 mg twice a day for three consecutive days ..
  20. pmc Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
    Ren Yuan Bai
    Ludwig Collaborative Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Neuro Oncol 13:974-82. 2011
    ..Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy...
  21. doi Coverage and costs of a school deworming programme in 2007 targeting all primary schools in Lao PDR
    Bounlay Phommasack
    National School Health Taskforce, Department of Hygiene and Prevention, Ministry of Health, Simuang Road, Vientiane Capital, Lao PDR
    Trans R Soc Trop Med Hyg 102:1201-6. 2008
    ..The Lao Government has addressed the problem by organizing regular anthelminthic chemotherapy with mebendazole 500mg for school and pre-school children in conjunction with health education activities incorporated into the ..
  22. ncbi Low efficacy of mebendazole against hookworm in Vietnam: two randomized controlled trials
    Carsten Flohr
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Am J Trop Med Hyg 76:732-6. 2007
    ..The treatment used in Vietnam is single dose oral mebendazole (Phardazone) 500 mg...
  23. ncbi Reducing intestinal nematode infection: efficacy of albendazole and mebendazole
    A Bennett
    Wellcome Trust Centre for the Epidemiology of Infectious Disease WTCEID, University of Oxford, South Parks Road, Oxford, UK OX1 3FY
    Parasitol Today 16:71-4. 2000
    The widespread use of mebendazole and albendazole for treating intestinal nematode infections in human populations is raising concerns that careful monitoring pro- cedures should be in place to identify any emergence of drug resistance...
  24. ncbi A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru
    Renee Larocque
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Trop Med Int Health 11:1485-95. 2006
    To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area.
  25. doi Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells
    Nicole Doudican
    New York University School of Medicine, New York, NY 10016, USA
    Mol Cancer Res 6:1308-15. 2008
    ..Strikingly, 4 of the 10 compounds (mebendazole, albendazole, fenbendazole, and oxybendazole) are benzimidazoles, a class of structurally related, tubulin-..
  26. doi Changed crystallinity of mebendazole solid dispersion: improved anthelmintic activity
    Juan J García-Rodriguez
    Department of Parasitology, Complutense University, 28040 Madrid, Spain
    Int J Pharm 403:23-8. 2011
    To improve the efficacy of mebendazole (MBZ), a poorly water-soluble drug, MBZ solid dispersions containing different proportions of low-substituted hydroxypropylcellulose (L-HPC) were prepared by lyophilization process...
  27. ncbi Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children
    Roberto Canete
    Hygiene, Epidemiology and Microbiology Centre, Matanzas City, Cuba
    World J Gastroenterol 12:6366-70. 2006
    To compare the efficacy and safety of five days apostrophe therapy of mebendazole (MBZ) versus quinacrine (QC) on human giardiasis in children.
  28. ncbi Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection
    Y R Yang
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Q 4006, Australia
    Trans R Soc Trop Med Hyg 99:937-41. 2005
    ..pregnancy, which may be suspected in this case, the favourable outcome after surgery and chemotherapy, and also a mental disability in a child following long-term intrauterine exposure to mebendazole, make the report particularly unique.
  29. ncbi Alveolar echinococcosis of the liver in an adult with human immunodeficiency virus type-1 infection
    W Zingg
    Division of Infectious Diseases and Hospital Epidemiology, Dept of Internal Medicine, University Hospital of Zurich, CH 8og91 Zurich, Switzerland
    Infection 32:299-302. 2004
    ..The patient had therapeutic mebendazole drug levels with only 1/10 of the normal drug dose...
  30. doi Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice
    Laura Ceballos
    Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires UNCPBA, Campus Universitario, 7000 Tandil, Argentina
    Parasitol Int 58:354-8. 2009
    ....
  31. ncbi Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae
    E Pozio
    Laboratory of Parasitology, Istituto Superiore di Sanita, Rome, Italy
    Clin Infect Dis 32:638-42. 2001
    ..mice were collected from muscle biopsies performed at different times (from 1 day to 16 months) following the end of treatment, indicating the failure of mebendazole to kill Trichinella parasites when they are encapsulating in muscles.
  32. doi Albendazole and mebendazole have low efficacy against Trichuristrichiura in school-age children in Kabale District, Uganda
    Annette Olsen
    DBL Centre for Health Research and Development, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, DK 1871 Frederiksberg C, Denmark
    Trans R Soc Trop Med Hyg 103:443-6. 2009
    ..groups of Trichuris trichiura-infected school-age children were treated with one dose 400mg albendazole, 100mg mebendazole twice daily for 3 d, or 100mg mebendazole twice daily for 5 d...
  33. ncbi The efficacy of chemotherapy with mebendazole in human cystic echinococcosis: long-term follow-up of 52 patients
    C Bartoloni
    Istituto di Clinica Medica Generale e Terapia Medica, , , Rome, Italy
    Ann Trop Med Parasitol 86:249-56. 1992
    ..granulosus infection of the liver, lungs, bone and/or soft tissues were treated for several months with oral mebendazole (50-60 mg kg-1 day-1), in divided doses after fat-rich meals, either without surgery (WS), post-surgery (PS) or ..
  34. ncbi Soil-transmitted nematode infections and mebendazole treatment in Mafia Island schoolchildren
    M Albonico
    Ivo de Carneri Foundation, Via IV Marzo 14, 10122, Torino, Italy
    Ann Trop Med Parasitol 96:717-26. 2002
    ..americanus was more prevalent. This survey was followed by a parasitological evaluation of mebendazole treatment using a single, 500-mg dose...
  35. ncbi A pediatric case of disseminated cystic echinococcosis successfully treated with mebendazole
    Zuhre Kaya
    Department of Pediatrics, Medical School of Gazi University, Ankara, Turkey
    Jpn J Infect Dis 57:7-9. 2004
    ..b>Mebendazole therapy produced complete resolution of the lung and kidney cysts...
  36. ncbi Effect of mebendazole on human cystic echinococcosis: the role of dosage and treatment duration
    K Vutova
    Department of Infectious Diseases, Parasitology, Epidemiology and Tropical Medicine, Faculty of Medicine, University of Medicine, Sofia, Bulgaria
    Ann Trop Med Parasitol 93:357-65. 1999
    Fifty-three patients with single, multiple and/or multi-organ hydatid cysts were treated with mebendazole, in varying dosages (30-70 mg/kg.day) and over varying periods (6-24 months)...
  37. ncbi A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children
    Roberto Canete
    Cuban Institute of Gastroenterology, Havana City, Cuba
    Curr Med Res Opin 22:2131-6. 2006
    ..However, cases refractory to treatment with these drugs are becoming more common worldwide...
  38. ncbi A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis
    A A Escobedo
    Departamento de Parasitologia, Hospital Pediatrico Pedro Borrás, Calle F No 616 esquina a 27, Plaza, Ciudad de La Habana, CP 10400, Cuba
    Ann Trop Med Parasitol 97:499-504. 2003
    ..children (aged 5-15 years) with confirmed Giardia lamblia infection were randomly allotted to treatment with mebendazole (200 mg three times daily for 3 days) or secnidazole (30 mg/kg, in a single dose)...
  39. ncbi Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo
    Tapas Mukhopadhyay
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2963-9. 2002
    We have found that mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines...
  40. ncbi Synthesis and antiparasitic activity of albendazole and mebendazole analogues
    Gabriel Navarrete-Vázquez
    Departamento de Farmacia, Facultad de Quimica, UNAM, CU, DF 04510, Mexico
    Bioorg Med Chem 11:4615-22. 2003
    Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans...
  41. pmc Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan
    Kow Tong Chen
    Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taipei, Taiwan, Republic of China
    Am J Public Health 93:489-92. 2003
    ..This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan...
  42. ncbi The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells
    Ji Ichiro Sasaki
    Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 1:1201-9. 2002
    ..In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo...
  43. ncbi Surgery and postoperative mebendazole in the treatment of hydatid disease
    Fuad F Ammari
    Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan
    Saudi Med J 23:568-71. 2002
    ..Our aim is to establish the outcome of chemotherapy in the postoperative period on secondary hydatid cyst...
  44. ncbi Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study
    Orna Diav-Citrin
    Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem, Israel
    Am J Obstet Gynecol 188:282-5. 2003
    b>Mebendazole is an anthelmintic that is commonly needed in women of reproductive age. Its use in pregnancy is a reason for concern for women and their health care providers...
  45. ncbi Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis
    Raymond A Smego
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Clin Infect Dis 37:1073-83. 2003
    ..cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2)...
  46. ncbi Effects of the Zanzibar school-based deworming program on iron status of children
    R J Stoltzfus
    Center for Human Nutrition, Department of International Health, The Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Am J Clin Nutr 68:179-86. 1998
    ..n = 952), and 4 schools in which students received thrice-yearly deworming (n = 970) with 500 mg generic mebendazole. Schools were randomly selected for evaluation and allocated to program groups...
  47. ncbi [Long term eradication rate of mebendazole therapy for strongyloidiasis]
    K Shikiya
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 66:354-9. 1992
    We treated 245 strongyloidiasis patients with 7 schedules of mebendazole (MBZ) and obtained the eradication rates at 8 months to 2 years after the final treatment as described follows; MBZ (100 mg) was given twice a day orally...
  48. ncbi The effect of iron fortification and de-worming on anaemia and iron status of Vietnamese schoolchildren
    Thi Le Huong
    The Nutrition Department, Hanoi Medical University, No 1 Ton That Tung Str, Dongda, Hanoi, Viet Nam
    Br J Nutr 97:955-62. 2007
    ..anaemic children aged 6-8 years were randomly assigned to receive either iron-fortified noodles or placebo, and mebendazole or placebo...
  49. ncbi Pharmacokinetic evaluation of guar gum-based colon-targeted drug delivery systems of mebendazole in healthy volunteers
    Y S R Krishnaiah
    Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, India
    J Control Release 88:95-103. 2003
    The pharmacokinetic evaluation of guar gum-based colon-targeted tablets of mebendazole against an immediate release tablet was carried out in human volunteers...
  50. ncbi Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh
    V Persson
    Section for International Maternal and Child Health, Uppsala University, Sweden
    Eur J Clin Nutr 55:1-9. 2001
    ..To study the effect of consumption of dark green leafy vegetables (DGLV) and sweet pumpkin on serum beta-carotene and retinol concentrations in children treated for Ascaris lumbricoides...
  51. ncbi Effect of mebendazole therapy during pregnancy on birth outcome
    N R de Silva
    Faculty of Medicine, University of Kelaniya, Sri Lanka
    Lancet 353:1145-9. 1999
    In areas endemic for hookworm, routine antenatal mebendazole therapy could greatly reduce the prevalence of anaemia in pregnancy...
  52. ncbi A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of Usigu Division, western Kenya
    E M Muchiri
    Division of Vector Borne Diseases, Ministry of Health, Nairobi, Kenya
    J Parasitol 87:413-8. 2001
    ..the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel, SmithKline Beecham) or mebendazole 600 mg (Vermox, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study ..
  53. ncbi Comparative clinical trial of mebendazole and metronidazole in giardiasis of children
    S M Sadjjadi
    Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Iran
    J Trop Pediatr 47:176-8. 2001
    ..Each group received either mebendazole tablets 200 mg thrice daily for 5 days or metronidazole tablet 15 mg/kg/day in three divided doses, for 7 days...
  54. ncbi Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice
    Daniele Martarelli
    Department of Experimental Medicine and Public Health, University of Camerino, Via M Scalzino 3, 62032 Camerino Macerata, Italy
    Cancer Chemother Pharmacol 61:809-17. 2008
    ..Recently, mebendazole has been proved to be effective against different cancers...
  55. ncbi Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children
    Rebecca J Stoltzfus
    Division of Nutritional Sciences, Cornell University, Ithaca, NY UNICEF, Zanzibar, Tanzania
    J Nutr 134:348-56. 2004
    ..A 12-mo randomized, placebo controlled, double-blind trial of 10 mg daily iron and/or mebendazole (500 mg) every 3 mo was conducted in a community-based sample of 459 Zanzibari children age 6-71 mo with ..
  56. ncbi Efficacy of mebendazole and albendazole for Ascaris lumbricoides and hookworm infections in an area with long time exposure for antihelminthes, Northwest Ethiopia
    Solomon Adugna
    Department of Biochemistry, College of Medicine and Health Sciences, University of Gondar, P O Box 1391, Gondar, Ethiopia
    Ethiop Med J 45:301-6. 2007
    The efficacy of mebendazole and albendazole in the treatment of Ascaris lumbricoides and hookworm infections was evaluated in school children in an area with long time exposure for broad spectrum anthelminthic drugs.
  57. pmc Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar
    M Albonico
    Ivo de Carneri Foundation, Milan, Italy
    Bull World Health Organ 81:343-52. 2003
    To evaluate the efficacy of and resistance to mebendazole (500 mg) and levamisole (40 or 80 mg), alone or in combination, for the treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm infections on Pemba Island - an area ..
  58. ncbi Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Am J Trop Med Hyg 74:1122-4. 2006
    To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis...
  59. ncbi Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Am J Med Sci 334:171-9. 2007
    ..Albendazole has been used in various ways in the treatment of cystic echinococcosis (CE)...
  60. ncbi [Human alveolar echinococcosis: an emerging zoonosis in Hungary and Europe]
    Tamás Sréter
    Országos Allategészségügyi Intézet, Vadbetegségek és Parazitológiai Osztály, Budapest
    Orv Hetil 145:1655-63. 2004
    ..The aim of the present paper is to summarize the current knowledge on the life cycle and distribution of E. multilocularis, and the epidemiology, clinical features, diagnosis, treatment and control of human alveolar echinococcosis...
  61. ncbi Clinical inquiries. What's the most effective treatment for giardiasis?
    Jeffrey D Kiser
    Eglin AFB Family Medicine Residency, Eglin AFB, FL, USA
    J Fam Pract 57:270-2. 2008
  62. ncbi [Overview of therapeutic options for cystic echinococcosis]
    E Brunetti
    Divisione di Malattie Infettive e Tropicali, IRCCS Policlinico S Matteo, Universita di Pavia, Pavia
    Parassitologia 46:53-5. 2004
    ..Data from long-term follow-up studies are also discussed, with emphasis on the resulting stage-specific criteria for treatment...
  63. ncbi Acute interstitial nephritis in a case of Ascaris lumbricoides infection
    Oliver Jung
    Department of Nephrology, Johann Wolfgang Goethe Univrsity, Frankfurt am Main, Germany
    Nephrol Dial Transplant 19:1625-8. 2004
  64. ncbi Impact of antihelminthic treatment on infection by Ascaris lumbricoides, Trichuris trichiura and hookworms in Covas, a rural community of Pernambuco, Brazil
    Luciana Carvalho Zani
    Departamento de Biologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Rev Inst Med Trop Sao Paulo 46:63-71. 2004
    ..Infected subjects were assigned to two groups for treatment with either albendazole (n = 62) or mebendazole (n = 57). Prevalence of infection fell significantly (p < 0.05) one month after treatment: Al (from 47...
  65. ncbi [Imaging methods in the diagnosis and therapy of cystic echinococcosis]
    W Hosch
    Abteilung Radiodiagnostik, Universitatsklinikum Heidelberg
    Rofo 176:679-87. 2004
    ..Apart from surgery three other treatment options are well established: (1) chemotherapy with albendazole or mebendazole, (2) percutaneous drainage and sterilization (PAIR) and (3) observation of inactive echinococcal stages ("watch ..
  66. ncbi A lasting solution is hard to achieve in primary hydatid disease of the spine: long-term results and an overview
    Haci Mustafa Ozdemir
    Department of Orthopedics and Traumatology, Meram School of Medicine, Selcuk University, Konya, Turkey
    Spine (Phila Pa 1976) 29:932-7. 2004
    ..Retrospective evaluation of patients with primary hydatid disease was done, with an overview of the pertinent literature. OBJECTIVES.: To determine the results of surgical decompression and antihelminthic treatment...
  67. ncbi [Spontaneous resolution of a retrovesical hydatidic cyst]
    Emilio Pintor-Holguín
    Departamento de Especialidades Médicas, Facultad de Ciencias de la Salud, Universidad Europea de Madrid, Madrid
    Enferm Infecc Microbiol Clin 22:246-7. 2004
  68. ncbi Treatment options for hepatic cystic echinococcosis
    Raymond A Smego
    Department of Medicine, The University of North Dakota, School of Medicine and Health Sciences, Fargo, ND, USA
    Int J Infect Dis 9:69-76. 2005
    ..Pre- and post-intervention chemotherapy with albendazole or mebendazole offers the advantage of reducing the risk of disease recurrence and intraperitoneal seeding of infection that ..
  69. ncbi [Selective vs. mass treatment with antihelminthic drugs: experience in two hyperendemic communities]
    Daniel Beltramino
    Servicio de Pediatria, Hospital J B Iturraspe, Santa Fe, Argentina
    Rev Panam Salud Publica 13:10-8. 2003
    ....
  70. ncbi [Hydatid cyst of the kidney]
    H Ketata
    Service d Urologie, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Urol (Paris) 38:259-65. 2004
    ..The percutaneous management, which includes puncture, aspiration, injection, and reaspiration, can be performed in very selected cases. However, the results of this technique are still under debate...
  71. ncbi [Echinococcus granulosus--diagnostics and therapy problems--case report]
    Brygida Adamek
    Slaska Akademia Medyczna w Katowicach Katedra i Zakład Ogólnej Biologii Lekarskiej
    Pol Merkur Lekarski 20:560-2. 2006
    ..The necessity of taking the echinococcosis into account in occasionally found liver cysts differential diagnostics and individual choice of the optimal therapeutic schema was underlined...
  72. ncbi Determination of the minmum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in rats
    Ping Chin Fan
    Institute of Tropical Medicine and Department of Parasitology, National Yangming University, Taipei, Taiwan
    Kaohsiung J Med Sci 21:448-51. 2005
    In order to determine the minimum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in Sprague-Dawley rats, each rat was infected with 30 metacercariae and treated with one of three ..
  73. ncbi Hydatid disease of the liver and associated hepatocellular carcinoma
    Eva Zold
    University of Debrecen, 3rd Department of Medicine, Debrecen, Hungary
    Clin Gastroenterol Hepatol 3:xxxv. 2005
  74. ncbi The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis
    T Todorov
    Department Clinic of Infectious, Parasitic and Tropical Diseases, Faculty of Medicine, University of Medicine, University Hospital St J Rilski, 1431 Sofia, Bulgaria
    Ann Trop Med Parasitol 99:649-59. 2005
    ..122 patients with abdominal and/or lung echinococcosis were randomly selected for treatment with albendazole or mebendazole. The main aims were to evaluate the effect of each drug on the hydatid cysts, to follow the changes in cyst ..
  75. ncbi Mass treatment for intestinal helminthiasis control in an Amazonian endemic area in Brazil
    Marcio Neves Boia
    Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, IOC, FiocruzRJ, Brasil
    Rev Inst Med Trop Sao Paulo 48:189-95. 2006
    ..samples for parasitological examination in 308 individuals, followed by a mass treatment with albendazole or mebendazole with coverage of 83% of the city population in 2003...
  76. ncbi [Thoracic hydatid cysts: news]
    M Elbiaze
    Service des Maladies Respiratoires, hôpital Ibn Rochd, Casablanca Maroc
    Rev Mal Respir 23:10S80-10S82. 2006
  77. ncbi An up-to-date on clinical management of human cystic echinococcosis
    A Teggi
    Dipartimento di Malattie Infettive, Ospedale Sant Andrea, University La Sapienza of Rome, Italy
    Parassitologia 46:405-7. 2004
    ..The therapeutic approach ranged from chemotherapy with benzimidazole carbamates (mebendazole and albendazole) to surgery, percutaneous non conventional treatment, and a "wait and see" approach, on the ..
  78. ncbi [Surgery of cardiac hydatid cysts. Experience of 39 years]
    G Orhan
    Service de Chirurgie Cardiovasculaire et Thoracique, centre hospitalier Siyami Ersek, Istanbul, Turquie
    Ann Cardiol Angeiol (Paris) 57:58-61. 2008
    ..In our series, most were located in the right heart. In such cases clamping the pulmonary artery is mandatory to prevent pulmonary migration. Careful resection is important for prevention of recurrence...
  79. ncbi Orthotopic liver transplantation for incurable alveolar echinococcosis: report of five cases from west China
    D Xia
    Center of Liver Transplantation, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Transplant Proc 37:2181-4. 2005
    ..Specific management is needed to improve the results: earlier decision for OLT in symptomatic disease, routine pre- and post-transplant therapy, reduced immunosuppression, and regular follow-up...
  80. ncbi Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes
    Jitra Waikagul
    Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Med Assoc Thai 88:233-7. 2005
    ..At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40 mg/kg) gave 94...
  81. ncbi An itchy holiday
    C van Nispen tot Pannerden
    Department of Internal Medicine, Infectious Diseases Section, Erasmus Medical Centre, Rotterdam, The Netherlands
    Neth J Med 65:188-90. 2007
    ..She was treated for various diagnoses, without success. Finally she was successfully treated for a clinically suspected hookwormrelated folliculitis. A brief overview of hookworm-related folliculitis is given...
  82. ncbi [The (children's) parasitic worms]
    Patrick L Scheid
    Laborabteilung I, Funktionsgebiet Diagnostik, Laborgruppe Med Mikrobiologie, Labor für Med Parasitologie, Zentrales Institut des Sanitätsdienstes der Bundeswehr Koblenz
    Kinderkrankenschwester 23:505-7. 2004
  83. ncbi [Nosology and epidemiology of human toxocarosis--the recent situation in Austria]
    Herbert Auer
    Abteilung fur Medizinische Parasitologie, Klinisches Institut fur Hygiene und Medizinische Mikrobiologie, Medizinische Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 116:7-18. 2004
    ....
  84. ncbi Single low-dose mebendazole administered quarterly for ascaris treatment
    John D Cleary
    School of Pharmacy, University of Mississippi Medical Center, Jackson, MS 39216, USA umsmed edu
    Am J Med Sci 333:340-5. 2007
    ..Intestinal parasites are difficult to eradicate in tropical climates where poor sanitation exists. In addition, pharmaceutical stability is poor making traditional three day dosing for the treatment of A. lumricoides challenging...
  85. ncbi Should deworming be included in antenatal packages in hookworm-endemic areas of developing countries?
    Renee Larocque
    Department of Epidemiology and Biostatistics, McGill University, Montreal, QC
    Can J Public Health 97:222-4. 2006
    ..However, deworming has not been included in antenatal care packages in most developing countries...
  86. ncbi Effect of two formulations of benzimidazole carbamates on the viability of cysts of Echinococcus granulosus in vivo
    K Daniel-Mwuambete
    Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal s n, 28040 Madrid, Spain
    Parasite 10:371-3. 2003
    Two different preparations, solution and suspension, of three benzimidazole carbamate drugs, mebendazole, albendazole and ricobendazole, were compared by analyzing their in vivo activity against Echinococcus granulosus cysts in a mouse ..
  87. ncbi Percutaneous sonographically guided treatment of hydatid cysts in sheep: direct injection of mebendazole and albendazole
    Yahya Paksoy
    Ultra Görüntüleme Merkezi, Konya, Turkey
    J Ultrasound Med 22:797-803. 2003
    ..The purpose of this study was to investigate the scolicidal effect of intracystic injection of benzimidazolic solutions in naturally infected sheep with hydatid disease...
  88. ncbi [Hepatic round focus with pruritus]
    Peter Stiefelhagen
    DRK Krankenhaus Westerwald, D 57627 Hachenburg
    MMW Fortschr Med 145:47, 51. 2003
  89. ncbi Primary ovarian echinococcosis
    Sema Zergeroglu
    Department of Pathology, Zekai Tahir Burak Hospital, Ankara, Turkey
    Arch Gynecol Obstet 270:285-6. 2004
    ..The incidence of genital system hydatid disease in abdominal operation is 0.1%. During a period of 20 years (1957-1977), 12 cases were reported. This disease has no specific symptoms and findings. It is diagnosed intraoperatively...
  90. ncbi Unusual localizations of hydatid disease
    C Col
    Department of Surgery, Abant Izzet Baysal University Medical School, Bolu, Turkey
    Acta Med Austriaca 30:61-4. 2003
    ..Chemotherapy is usually given because of the risk of recurrence; this medical treatment consists in albendazole and mebendazole administration for 3-6 months in the postoperative period.
  91. ncbi Efficacy of alebendazole and mebendazole in the treatment of Ascaris and Trichuris infections
    Mengistu Legesse
    Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Ethiop Med J 40:335-43. 2002
    This study was conducted to evaluate the efficacy of 100 mg mebendazole administered twice a day for three consecutive days and a single dose of 400 mg albendazole for the treatment of single or mixed Ascaris lumbricoides and Trichuris ..
  92. ncbi [Target chemotherapy of intestinal nematode infection in area with low endemicity]
    Tao Zhang
    Department of Parasitology, Nanjing Medical University, Nanjing 210029
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 20:174-6. 2002
    ..To evaluate the control measures for intestinal nematodiasis in endemic area with low prevalence and intensity of infection...
  93. ncbi Two cases of imported gnathostomiasis in Spanish women
    S Puente
    Seccion de Medicina Tropical, Servicio de Enfermedades Infecciosas, Hospital Carlos III, 28029 Madrid, Spain
    Eur J Clin Microbiol Infect Dis 21:617-20. 2002
    ..The cases reported here demonstrate the increasing frequency with which human gnathostomiasis is being diagnosed in nonendemic countries as a result of more extensive international travel and migration...
  94. ncbi [Adult ascaris in the intrahepatic bile ducts]
    M C Receveur
    Service de Medecine, centre hospitalier de Mayotte, BP 04, 97600 Mamoudzou
    Presse Med 31:1705. 2002
  95. ncbi Surgery and postoperative mebendazole in the treatment of hydatid disease
    Abdul Wahed N Meshikhes
    Saudi Med J 23:1425; author reply 1425. 2002
  96. ncbi An outbreak of trichinellosis due to consumption of bear meat infected with Trichinella nativa, in 2 northern Saskatchewan communities
    Roberta S Schellenberg
    Department of Internal Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Infect Dis 188:835-43. 2003
    ..All exposed individuals were treated with mebendazole or albendazole, and symptomatic patients received prednisone...
  97. ncbi Echinococcus granulosus infection: clinical presentation, medical treatment and outcome
    Peter Kern
    Section of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center, Robert Kochstrasse 8, 89081, Ulm, Germany
    Langenbecks Arch Surg 388:413-20. 2003
    ..Adjunct treatment with benzimidazoles is the cornerstone of the interdisciplinary approach in cystic echinococcosis...
  98. ncbi Evaluation of the Integrated Management of Childhood Illness guidelines for treatment of intestinal helminth infections among sick children aged 2-4 years in western Kenya
    Renu Garg
    International Child Survival and Emerging Infections Program Support Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop F 22, 4770 Buford Hwy, Atlanta, Georgia 30341, USA
    Trans R Soc Trop Med Hyg 96:543-8. 2002
    ..and to evaluate the nutritional benefit of treating sick children without pallor with an anthelmintic (mebendazole is already part of IMCI treatment for sick children aged 2-4 years with palmar pallor in areas where hookworm ..
  99. ncbi Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole
    T Todorov
    Medical Academy, Sofia, Bulgaria
    Ann Trop Med Parasitol 86:59-66. 1992
    The relative efficacy of mebendazole (MEB) and albendazole (ALB) was tested by treating 51 patients with single, multiple and multi-organ hydatid cysts; 28 patients were treated with MEB, 50-70 mg kg-1 body weight daily for six to 24 ..
  100. pmc Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides
    Aissatou Diawara
    Institute of Parasitology, McGill University, Quebec, Canada
    PLoS Negl Trop Dis 3:e397. 2009
    ..The benzimidazole (BZ) drugs, albendazole (ALB) and mebendazole (MBZ), are commonly used for mass treatment for STH...
  101. doi In vitro nematicidal activity of extracts of Canthium mannii (Rubiaceae), on different life-cycle stages of Heligmosomoides polygyrus (Nematoda, Heligmosomatidae)
    J Wabo Pone
    Department of Animal Biology, Faculty of Science, University of Dschang, PO Box 067, Dschang, Cameroon
    J Helminthol 84:156-65. 2010
    ..The different stages of the life cycle were also put in contact with the same concentration of mebendazole (MBZ, positive control)...

Research Grants15

  1. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    ..Methods were developed to extract these nuclear antigens (NA). It was further shown that mebendazole treatment of mice depletes NA from host nuclei and simultaneously leads to diminution in size of infected cell ..
  2. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  3. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2007
    ..The study will fill critical gaps in knowledge and inform policy on the efficacy of selective micronutrient interventions in pregnancy and early childhood to improve school-aged cognition. ..
  4. Heavy Metal Exposures in Women and Children, the Role of Nutrients
    Rebecca Stoltzfus; Fiscal Year: 2007
    ..The symposium will result in proceedings published in the Journal of Nutrition, one of the most widely read nutrition publications. ..