midazolam

Summary

Summary: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Top Publications

  1. ncbi Comparison of midazolam sedation with or without fentanyl in cataract surgery
    O Yalcin Cok
    Department of Anesthesiology and Reanimation, Baskent University, Faculty of Medicine, Ankara, Turkey
    Acta Anaesthesiol Belg 59:27-32. 2008
  2. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
  3. doi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
  4. pmc Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
    Fabio Ferrarelli
    Department of Psychiatry and Anesthesiology, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 107:2681-6. 2010
  5. ncbi Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
  6. doi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
  7. ncbi Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial
    Bibek Talukdar
    Department of Pediatrics, Maulana Azad Medical College and Asssociated Chacha Nehru Bal Chikitsalaya CNBC, Delhi 110031, India
    Brain Dev 31:744-9. 2009
  8. ncbi Intranasal midazolam for prolonged convulsive seizures
    N O Kutlu
    Department of Pediatrics, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Brain Dev 22:359-61. 2000
  9. doi Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy
    Maija Holsti
    Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Arch Pediatr Adolesc Med 164:747-53. 2010
  10. ncbi Intrathecal midazolam I: a cohort study investigating safety
    Adam P Tucker
    Department of Anaesthesia, Monash Medical Centre, Monash University, 246 Clayton Road, Victoria 3168, Australia
    Anesth Analg 98:1512-20, table of contents. 2004

Detail Information

Publications315 found, 100 shown here

  1. ncbi Comparison of midazolam sedation with or without fentanyl in cataract surgery
    O Yalcin Cok
    Department of Anesthesiology and Reanimation, Baskent University, Faculty of Medicine, Ankara, Turkey
    Acta Anaesthesiol Belg 59:27-32. 2008
    We compared the effect of midazolam sedation with or without fentanyl on the hemodynamic parameters, sedation, and pain and satisfaction profile in cataract surgery...
  2. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  3. doi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
    Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects...
  4. pmc Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
    Fabio Ferrarelli
    Department of Psychiatry and Anesthesiology, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 107:2681-6. 2010
    ..this hypothesis by comparing EEG responses to TMS during wakefulness and LOC induced by the benzodiazepine midazolam. Unlike spontaneous sleep states, a subject's level of vigilance can be monitored repeatedly during ..
  5. ncbi Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
    ..The authors addressed this issue by evaluating the effect of propofol on dendritic growth and arbor expansion of developing gamma-aminobutyric acid-positive (GABAergic) interneurons...
  6. doi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
    ..The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location...
  7. ncbi Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial
    Bibek Talukdar
    Department of Pediatrics, Maulana Azad Medical College and Asssociated Chacha Nehru Bal Chikitsalaya CNBC, Delhi 110031, India
    Brain Dev 31:744-9. 2009
    A study was done to examine the efficacy of buccal midazolam in controlling convulsion in children by comparing it with intravenous diazepam, a standard mode of treating convulsions...
  8. ncbi Intranasal midazolam for prolonged convulsive seizures
    N O Kutlu
    Department of Pediatrics, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Brain Dev 22:359-61. 2000
    In order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures...
  9. doi Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy
    Maija Holsti
    Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Arch Pediatr Adolesc Med 164:747-53. 2010
    To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy.
  10. ncbi Intrathecal midazolam I: a cohort study investigating safety
    Adam P Tucker
    Department of Anaesthesia, Monash Medical Centre, Monash University, 246 Clayton Road, Victoria 3168, Australia
    Anesth Analg 98:1512-20, table of contents. 2004
    Despite conflicting evidence regarding the safety of intrathecal midazolam from animal investigations, its clinical use is increasing...
  11. ncbi Analgesic efficacy of two doses of intrathecal midazolam with bupivacaine in patients undergoing cesarean delivery
    Smita Prakash
    Department of Anesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    Reg Anesth Pain Med 31:221-6. 2006
    In this prospective, randomized, double-blind, placebo-controlled study, we investigated the postoperative analgesic efficacy of 2 doses of intrathecal midazolam as an adjunct to bupivacaine for spinal anesthesia.
  12. ncbi Propofol infusion versus intermittent meperidine and midazolam injection for conscious sedation in ERCP
    Pradermchai Kongkam
    Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
    J Gastrointestin Liver Dis 17:291-7. 2008
    ..This study was conducted to compare satisfaction, recovery score, and recovery/safety profiles for ERCP sedation between continuous infusion of propofol and conventional sedation...
  13. ncbi Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis
    K M Ho
    Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia
    Anaesth Intensive Care 36:365-73. 2008
    Intrathecal midazolam binds with gamma aminobutyric acid-A receptors in the spinal cord leading to an analgesic effect...
  14. doi Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
    Malcie Mesnil
    Department of Anesthesiology and Critical Care Lapeyronie DAR A, Montpellier I University and Montpellier University Lapeyronie Hospital, Institut National de la Sante et de la Recherche Medicale INSERM, Equipe soutenue par la Région et l Inserm ERI 25, route de Ganges, 34295 Montpellier, Cedex 5, France
    Intensive Care Med 37:933-41. 2011
    To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (i.v.) sedation with propofol or midazolam.
  15. doi Disruptive effect of midazolam on fear memory reconsolidation: decisive influence of reactivation time span and memory age
    Silvia G Bustos
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Cordoba, Argentina
    Neuropsychopharmacology 34:446-57. 2009
    ..memory was reactivated by exposure to the associated context for different periods of time that were followed by midazolam (MDZ) administration. We also studied MDZ amnesic effect after reactivating fear memories of several ages...
  16. ncbi Preoperative intravenous midazolam: benefits beyond anxiolysis
    Kevin P Bauer
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Clin Anesth 16:177-83. 2004
    To evaluate the effect of midazolam on the global perioperative experience, including patient satisfaction, postoperative nausea and vomiting, postoperative pain, and perioperative anxiety and amnesia.
  17. ncbi Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy
    M H Kim
    Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Br J Anaesth 86:77-9. 2001
    In the present double-blind study we aimed to evaluate the postoperative analgesic effects of intrathecal midazolam with bupivacaine following haemorrhoidectomy...
  18. ncbi Midazolam vs ondansetron for preventing postoperative nausea and vomiting: a randomised controlled trial
    Y Lee
    Buddhist Tzu Chi Medical Center, Tzu Chi University School of Medicine, No 707 Sec 3 Jhong Yang Rd, Hualien, Taiwan, ROC
    Anaesthesia 62:18-22. 2007
    We compared the prophylactic anti-emetic efficacy of midazolam and ondansetron in 90 patients scheduled for minor gynaecological (hysteroscopy) or urological (ureteroscopy) procedures planned to last 1-2 h under sevoflurane anaesthesia ..
  19. ncbi Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy
    Megan E VanNatta
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis Indiana 46202, USA
    Am J Gastroenterol 101:2209-17. 2006
    ..Propofol in combination with opioids and/or benzodiazepines can be titrated to moderate sedation, which might be safer...
  20. ncbi Induction of anaesthesia with either midazolam or propofol in rabbits premedicated with fentanyl/fluanisone
    M A Martinez
    Department of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 164:803-6. 2009
    ..1 ml/kg fentanyl/fluanisone and then randomly allocated to be anaesthetised with either midazolam or propofol. Anaesthesia was then maintained with isoflurane...
  21. doi Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects
    Matthias Hoch
    Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil, Switzerland
    Eur J Clin Pharmacol 69:523-32. 2013
    ..Therefore, a study was conducted to investigate the effects of multiple-dose almorexant on the pharmacokinetics of midazolam and simvastatin, two CYP3A4 model substrates.
  22. ncbi Intranasal midazolam vs rectal diazepam in acute childhood seizures
    Madhumita Bhattacharyya
    Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Pediatr Neurol 34:355-9. 2006
    ..seizure episodes in 46 children were randomly assigned to receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg body weight and 0.2 mg/kg body weight, respectively...
  23. doi A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations
    Gerrit Jan de Haan
    SEIN Epilepsy Institute in The Netherlands Foundation Heemstede, The Netherlands
    Epilepsia 51:478-82. 2010
    ..if an alternative route of administration of a benzodiazepine was equally effective, we compared a novel midazolam HCl concentrated nasal spray (MDZ-n) with diazepam rectal solution (DZP-r) in the treatment of prolonged ..
  24. ncbi Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial
    John J Vargo
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastroenterology 123:8-16. 2002
    ..has been no prospective, randomized comparison of gastroenterologist-administered propofol to meperidine and midazolam for endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography...
  25. pmc Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis
    Jason McMullan
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Acad Emerg Med 17:575-82. 2010
    Rapid treatment of status epilepticus (SE) is associated with better outcomes. Diazepam and midazolam are commonly used, but the optimal agent and administration route is unclear.
  26. ncbi A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes
    Mallorie Clement Jerdi
    Clinical Pharmacology and Toxicology, Geneva University Hospitals, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    J Pharm Biomed Anal 35:1203-12. 2004
    ..approach including five probe substances, namely caffeine, flurbiprofen, omeprazole, dextromethorphan and midazolam. All substances were administered simultaneously and a single plasma sample was obtained 2h after the ..
  27. ncbi Effects of intrathecal midazolam in spinal anaesthesia: a prospective randomised case control study
    B K Shadangi
    Department of Anaesthesiology, All India Institute of Medical Scences, Ansari Nagar, New Delhi 110029, India
    Singapore Med J 52:432-5. 2011
    Subarachnoid block with local anaesthetics and adjuvants has been extensively used for surgery. Intrathecal midazolam produces antinociception and potentiates the effect of local anaesthetics...
  28. doi Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial
    Lorella Fanti
    Department of Gastroenterology, Vita Salute University of Milano, IRCCS H San Raffaele, Milano, Italy
    Am J Gastroenterol 104:1119-24. 2009
    The aim was to compare patients' and endoscopists' satisfaction in terms of efficacy and safety of remifentanil patient-controlled analgesia (PCA) during colonoscopy with that of a combination of midazolam and meperidine.
  29. ncbi Low dose intravenous midazolam for prevention of PONV, in lower abdominal surgery--preoperative vs intraoperative administration
    Mohammad Reza Safavi
    Department of Anesthesiology and Intensive Care Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Middle East J Anesthesiol 20:75-81. 2009
    The aim of the present study was to compare anti-emetic efficacy of low dose midazolam premedication (35 microg/kg) 15 minutes before induction of anesthesia with midazolam (35 microg/kg) administered intravenously 30 min before ..
  30. doi Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study
    Iyad Khamaysi
    Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
    J Hepatol 54:72-7. 2011
    ..The aim of this study is to determine whether the use of propofol, for upper endoscopy in patients with cirrhosis, precipitates sub-clinical HE...
  31. ncbi Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo
    Ping He
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Clin Pharmacol Ther 77:373-87. 2005
    ..A single oral dose of midazolam was administered to 26 healthy subjects. The variability in midazolam oral clearance was 11-fold...
  32. pmc Ketamine and midazolam sedation for pediatric gastrointestinal endoscopy in the Arab world
    Mohamad Iqbal S Miqdady
    Pediatric Department, Medical School, Jordan University of Science and Technology, Irbid 3030, Jordan
    World J Gastroenterol 17:3630-5. 2011
    To evaluate the safety and effectiveness of intravenous ketamine-midazolam sedation during pediatric endoscopy in the Arab world.
  33. ncbi The analgesic and sedative effects of intrathecal midazolam in perianal surgery
    A Yegin
    Akdeniz University Medical Faculty, Department of Anaesthesiology, Antalya, Turkey
    Eur J Anaesthesiol 21:658-62. 2004
    Our purpose was to evaluate the analgesic and sedative effects of intrathecal midazolam when added to spinal bupivacaine in patients undergoing perianal surgery under spinal anaesthesia.
  34. ncbi Effect of intravenous midazolam premedication on postoperative nausea and vomiting after cholecystectomy
    Seied Morteza Heidari
    Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Anaesthesiol Taiwan 42:77-80. 2004
    ..However PONV continues to be a common postoperative complication. Midazolam premedication in pediatric patients has been reported to reduce the incidence of PONV...
  35. ncbi Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department
    Sandip A Godambe
    Division of Pediatric Emergency Medicine, LeBonheur Children s Medical Center, Memphis, Tennessee, USA
    Pediatrics 112:116-23. 2003
    To compare the effectiveness of 2 medication regimens, propofol/fentanyl (P/F) and ketamine/midazolam (K/M), for brief orthopedic emergency department procedural sedation...
  36. pmc Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest
    Philip E Empey
    Department of Pharmacy and Therapeutics, School of Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:1221-8. 2012
    ..objectives were to determine the effect of mild hypothermia on the in vivo pharmacokinetics of fentanyl and midazolam, two clinically relevant cytochrome P450 3A substrates, after cardiac arrest and to investigate the mechanisms ..
  37. ncbi The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature
    A A Weinbroum
    Post Anesthesia Care Unit, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel
    Eur J Anaesthesiol 18:789-97. 2001
    b>Midazolam may occasionally precipitate hostility and violence instead of tranquility...
  38. ncbi Deep sedation occurs frequently during elective endoscopy with meperidine and midazolam
    Sandeep Patel
    Section of Endoscopy, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    Am J Gastroenterol 100:2689-95. 2005
    ..The aims of this study were to prospectively evaluate the incidence and risk factors of deep sedation during elective endoscopy with meperidine and midazolam intended to maintain a level of moderate sedation.
  39. ncbi Midazolam: an effective antiemetic after cardiac surgery--a clinical trial
    Orathy Patangi Sanjay
    DNB, Department of Anesthesiology, St John s Medical College Hospital, Bangalore 560034, Karnataka, India
    Anesth Analg 99:339-43, table of contents. 2004
    ..To assess the antiemetic property of midazolam, we undertook this double-blinded, randomized trial in 200 patients undergoing cardiac surgery involving ..
  40. ncbi Intranasal midazolam therapy for pediatric status epilepticus
    Timothy R Wolfe
    Department of Emergency Medicine, Jordan Valley Hospital, West Jordan, UT 84088, USA
    Am J Emerg Med 24:343-6. 2006
    ..Intranasal midazolam, which delivers antiepileptic medication directly to the blood and cerebrospinal fluid via the nasal mucosa, is ..
  41. ncbi Use of intranasal midazolam to treat acute seizures in paediatric community settings
    M G Harbord
    Department of Paediatrics and Child Health, Flinders Medical Centre, Adelaide, South Australia 5042, Australia
    J Paediatr Child Health 40:556-8. 2004
    To evaluate the acceptability of intranasal midazolam (INM) in acute seizure management in the community.
  42. ncbi Analgesic effects of systemic midazolam: comparison with intrathecal administration
    Tomoki Nishiyama
    Department of Anesthesiology, The Univesity of Tokyo, Japan
    Can J Anaesth 53:1004-9. 2006
    b>Midazolam has antinociceptive effects when administered intrathecally, while its effects associated with systemic administration remain controversial...
  43. ncbi Evidence of significant contribution from CYP3A5 to hepatic drug metabolism
    Weili Huang
    Department of Pharmaceutics, Box 357610, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 32:1434-45. 2004
    ..Based on this parameter, CYP3A5 was more active than CYP3A4 in catalyzing total midazolam hydroxylation (3-fold) and lidocaine demethylation (1.4-fold)...
  44. doi Safe and effective sedation in endoscopic submucosal dissection for early gastric cancer: a randomized comparison between propofol continuous infusion and intermittent midazolam injection
    Shinsuke Kiriyama
    Department of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol 45:831-7. 2010
    ..The aim of this study was to compare the safety profiles and recovery scores propofol continuous infusion and intermittent midazolam (MDZ) injection as sedation for ESD.
  45. pmc The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation
    Hyun Seung Jin
    Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    J Korean Med Sci 22:693-7. 2007
    ..7 cases). The total duration of sedation (8.0 days vs. 11.5 days) also tended to decrease. These findings suggest that application of protocol-based sedation with the COMPORT scale may benefit children requiring mechanical ventilation...
  46. pmc Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis
    Kazuhiro Tokuda
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:16788-95. 2010
    ..In rat hippocampal slices, we compared midazolam, an anesthetic BDZ, with clonazepam, an anticonvulsant/anxiolytic BDZ that activates CBRs selectively...
  47. ncbi Prehospital intranasal midazolam for the treatment of pediatric seizures
    Maija Holsti
    Division of Pediatric Emergency Medicine, Department of Pediatrics, Primary Children s Medical Center University of Utah, Salt Lake City, UT 84158, USA
    Pediatr Emerg Care 23:148-53. 2007
    The local emergency medical services (EMS) council implemented a new pediatric treatment protocol using a Mucosal Atomization Device (MAD) to deliver intranasal (IN) midazolam for seizure activity.
  48. ncbi Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
    Yvonne S Lin
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA
    Mol Pharmacol 62:162-72. 2002
    ..Overall, CYP3A5 protein content accounted for 31% of the variability in hepatic midazolam hydroxylation activity...
  49. ncbi Reemergence of stroke deficits with midazolam challenge
    Ronald M Lazar
    Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 33:283-5. 2002
    ..a step toward assessing whether neurotransmitter systems underlie poststroke clinical improvement, we selected midazolam, a gamma-aminobutyric acid(A) (GABA(A)) agonist, for systemic administration to measure general or stroke-..
  50. ncbi The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans
    Junko Imanaga
    Department of Clinical Pharmacology and Therapeutics, Oita University Faculty of Medicine, Oita, Japan
    Pharmacogenet Genomics 21:84-93. 2011
    The objective was to determine the effects of the SLCO2B1 c.1457C> T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.
  51. ncbi Comparative study of the antiemetic efficacy of ondansetron, propofol and midazolam in the early postoperative period
    H Unlugenc
    Cukurova University, Faculty of Medicine, Department of Anaesthesiology, Adana, Turkey
    Eur J Anaesthesiol 20:668-73. 2003
    To compare the antiemetic efficacy of ondansetron with two different hypnotic drugs (propofol 15 mg, midazolam 1 and 2 mg) for the treatment of established postoperative nausea and vomiting (PONV).
  52. ncbi Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury
    Michèle Tanguy
    Département d anesthésie réanimation 1, Hopital de Pontchaillou, Cedex, France
    J Neurotrauma 29:1105-10. 2012
    ..The objective was to compare the effects of propofol to midazolam on cerebral biomarkers at the acute phase of severe TBI patients...
  53. doi Functional magnetic resonance imaging (fMRI) in children sedated with propofol or midazolam
    Marco Gemma
    Anesthesia and Intensive Care Unit, Head and Neck Department, Vita Salute University, San Raffaele Scientific Institute, Milan, Italy
    J Neurosurg Anesthesiol 21:253-8. 2009
    ..This study compares the effect of propofol and midazolam on the fMRI auditory activation pattern in children...
  54. ncbi Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy?
    M Scheepers
    Heathfield, 30 Denmark Road, Gloucester, GL1 3HZ, UK
    Seizure 9:417-22. 2000
    The aim of this study was to determine whether intranasal midazolam is a safe and effective rescue medication in adolescent and adult patients with severe epilepsy...
  55. ncbi Anticonvulsant treatment of sarin-induced seizures with nasal midazolam: an electrographic, behavioral, and histological study in freely moving rats
    E Gilat
    Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona, 74100 Israel
    Toxicol Appl Pharmacol 209:74-85. 2005
    ..Effective management of these seizures is critical for minimization of brain damage. Nasal application of midazolam (1...
  56. ncbi Nasal midazolam effects on childhood acute seizures
    T Fisgin
    Department of Pediatric Hematology, Dr Sami Ulus Child Health and Disease Center, Ankara, Turkey
    J Child Neurol 15:833-5. 2000
    ..Sami Ulus Child Health and Disease Center, were included in this study. Midazolam (5 mg/mL) 0.2 mg/kg was administered intranasally in 30 seconds by an injector...
  57. ncbi Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis
    Tamsin A Knox
    Nutrition Infection Division, Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    J Acquir Immune Defic Syndr 49:358-68. 2008
    ..Ritonavir is a powerful inhibitor of cytochrome P450 3A (CYP3A) that metabolizes many antiretrovirals. We examined the effect of ritonavir and of chronic viral hepatitis (CVH) status on CYP3A activity...
  58. doi Olfactory fear conditioning paradigm in rats: effects of midazolam, propranolol or scopolamine
    Juliana A V Kroon
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Neurobiol Learn Mem 91:32-40. 2009
    ..the study of fear-induced behavior and whether compounds used in humans for emotional-related disorders such as midazolam, propranolol, or scopolamine, applied during the different stages of fear conditioning (acquisition, ..
  59. ncbi Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol
    Usha Padmanabhan
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Anesth Analg 109:1448-55. 2009
    ..We sought to determine if the use of propofol alone results in less cognitive impairment at discharge than the use of propofol plus midazolam and/or fentanyl in patients presenting for elective outpatient colonoscopy.
  60. ncbi Intrathecal midazolam added to bupivacaine improves the duration and quality of spinal anaesthesia
    N Bharti
    Department of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India
    Acta Anaesthesiol Scand 47:1101-5. 2003
    The antinociceptive action of intrathecal midazolam is well documented. In this prospective study, we investigated the addition of midazolam to intrathecal bupivacaine on the duration and quality of spinal blockade.
  61. ncbi Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I, Gastroenterology and Interventional Endoscopy, Hospital Siloah, Hannover, Germany
    Scand J Gastroenterol 44:1244-51. 2009
    b>Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted...
  62. ncbi Sedation for endoscopy: the safe use of propofol by general practitioner sedationists
    Anthony C Clarke
    Mugga Wara and Brindabella Endoscopy Centres, Canberra, ACT
    Med J Aust 176:158-61. 2002
    ..To determine the incidence of adverse events related to an endoscopy sedation regimen that included propofol, delivered by general practitioner (GP) sedationists...
  63. ncbi Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children
    T Mahmoudian
    Department of Child Neurology, Medical University of Isfahan, Isfahan, Iran
    Epilepsy Behav 5:253-5. 2004
    b>Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus...
  64. doi Patient-controlled analgesia and sedation with alfentanyl versus fentanyl for colonoscopy: a randomized double blind study
    Burhanettin Usta
    Department of Anesthesiology, Fatih University School of Medicine, Ankara, Turkey
    J Clin Gastroenterol 45:e72-5. 2011
    ....
  65. ncbi Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia
    R Bulach
    Department of Anaesthesia and Pain Management, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    Br J Anaesth 94:300-5. 2005
    Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam.
  66. ncbi Midazolam challenge reinduces neurological deficits after transient ischemic attack
    Ronald M Lazar
    From the Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 34:794-6. 2003
    ..Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients would ..
  67. ncbi Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam
    Iain S McGregor
    School of Psychology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Neurosci 24:4134-44. 2004
    ..Rats received either midazolam (0.75 mg/kg, s.c...
  68. ncbi Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial
    J E Wathen
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center The Children s Hospital, Denver, CO, USA
    Ann Emerg Med 36:579-88. 2000
    ..conducted to investigate the frequency and severity of adverse effects, specifically emergence phenomena, experienced by patients receiving intravenous ketamine with or without midazolam for sedation in a pediatric emergency department.
  69. ncbi Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam
    Marcus W Agelink
    Department of Neurocardiology, Institute of Biological Psychiatry and Neuroscience, Evangelical Clinics Gelsenkirchen, Ruhr University of Bochum, Germany
    Crit Care Med 30:997-1006. 2002
    To evaluate the effects of intravenously applied diazepam, lorazepam, and midazolam on autonomic neurocardiac regulation assessed by standardized measurements of heart rate variability.
  70. ncbi Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization
    S M Auden
    Departments of Anesthesiology, Pediatrics, and Family and Community Medicine of the University of Louisville and Kosair Children s Hospital, Louisville, KY 40202, USA
    Anesth Analg 90:299-305. 2000
    ..We compared this IM combination to oral (PO) ketamine/midazolam in children having cardiac catheterization...
  71. ncbi Changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia
    M Yamakage
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    J Clin Anesth 11:375-9. 1999
    To investigate changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia.
  72. ncbi Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study
    M F Hebert
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 84:248-53. 2008
    ..evaluate the effects of pregnancy on CYP3A and P-glycoprotein (P-gp) activities, as measured by disposition of midazolam and digoxin, respectively. Thirteen women received digoxin (0.25 mg p.o.) and midazolam (2 mg p.o...
  73. doi Reconsolidation of a morphine place preference: impact of the strength and age of memory on disruption by propranolol and midazolam
    M J F Robinson
    Department of Psychology, McGill University, 1205 Dr Penfield Ave, Montreal, Quebec, Canada
    Behav Brain Res 213:201-7. 2010
    ..reactivated drug-free, and immediately afterwards animals received an injection of propranolol (10mg/kg, SC), midazolam (1mg/kg, IP), both amnestic agents combined, or saline...
  74. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
    ..This study was designed to evaluate this relation for four commonly used anesthetic drugs: propofol, midazolam, isoflurane, and alfentanil.
  75. doi A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    Thomas Strøm
    Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Denmark
    Lancet 375:475-80. 2010
    ..We aimed to establish whether duration of mechanical ventilation could be reduced with a protocol of no sedation versus daily interruption of sedation...
  76. ncbi Safety of intravenous midazolam and fentanyl for pediatric GI endoscopy: prospective study of 1578 endoscopies
    Petar Mamula
    Division of GI and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastrointest Endosc 65:203-10. 2007
    ..Data on safety of intravenous sedation in pediatric GI endoscopy are sparse...
  77. pmc Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial
    D Stolz
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Thorax 59:773-6. 2004
    ..A randomised, placebo controlled, double blind study was undertaken to determine whether hydrocodone in combination with midazolan improves cough suppression during FB without increasing the risk of desaturation...
  78. ncbi Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery
    J A Alhashemi
    Department of Anesthesia and Critical Care, King Abdulaziz University, King Abdulaziz University Hospital PO Box 31648, Jeddah, Saudi Arabia
    Br J Anaesth 96:722-6. 2006
    Cataract surgery is commonly performed under local anaesthesia with midazolam sedation. Dexmedetomidine, a sedative-analgesic, is devoid of respiratory depressant effects, and its use in cataract surgery has not been reported...
  79. doi Effects of midazolam on brain injury after transient focal cerebral ischemia in rats*
    Baiping Lei
    Department of Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    J Neurosurg Anesthesiol 21:131-9. 2009
    The benzodiazepine, midazolam, is commonly used for sedation and anesthesia in the operating room and the intensive care unit where there is a risk of cerebral ischemia...
  80. ncbi Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient
    Shailesh Shah
    Department of Pediatric Anesthesiology and Pain Medicine, Arkansas Children s Hospital, Little Rock, AR, 72202, USA
    J Anesth 23:126-8. 2009
    ..A combination of oral ketamine and midazolam was mixed in the beverage Dr Pepper to mask the taste and the appearance of the drugs...
  81. doi The effect of midazolam on neutrophil mitogen-activated protein kinase
    Kamran Ghori
    Cork University Hospital, Cork, Ireland
    Eur J Anaesthesiol 27:562-5. 2010
    ..The objectives of this in-vitro investigation were to examine the effect of midazolam on neutrophil p38 MAPK activation (phosphorylation) following in-vitro ischaemia-reperfusion injury, and the ..
  82. ncbi Etomidate and midazolam for procedural sedation: prospective, randomized trial
    Gregory S Hunt
    Department of Emergency Medicine, St Luke s Hospital, New Bedford, MA 02740, USA
    Am J Emerg Med 23:299-303. 2005
    To evaluate whether there is a difference in the time of sedation and time to patient disposition in patients undergoing procedural sedation with etomidate and midazolam.
  83. ncbi Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients
    Erin R Lepper
    Science Applications International Corporation Frederick, Maryland, USA
    Clin Cancer Res 11:7398-404. 2005
    To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe.
  84. ncbi Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial
    G Clark
    Centre valaisan de pneumologie, Geneva University Hospitals, Geneva, Switzerland
    Eur Respir J 34:1277-83. 2009
    In this study, we questioned whether propofol provided clinical benefits compared with midazolam in terms of neuropsychometric recovery, safety profile and patient tolerance...
  85. ncbi Nurse-administered propofol sedation compared with midazolam and meperidine for EUS: a prospective, randomized trial
    John DeWitt
    Departments of Gastroenterology and Hepatology, Indiana University Medical Center and Regenstrief Institute, Inc, Indianapolis, Indiana, USA
    Gastrointest Endosc 68:499-509. 2008
    The utility of nurse-administered propofol sedation (NAPS) compared with midazolam and meperidine (M/M) for EUS is not known.
  86. doi Dexmedetomidine-ketamine and midazolam-ketamine combinations for sedation in pediatric patients undergoing extracorporeal shock wave lithotripsy: a randomized prospective study
    Senem Koruk
    Department of Anesthesiology and Reanimation, Gaziantep University Medical School, 27310 Sehitkamil, Gaziantep, Turkey
    J Anesth 24:858-63. 2010
    ..The aim of this randomized prospective study was to compare the effects of dexmedetomidine-ketamine and midazolam-ketamine combinations on the recovery time, hemodynamic and respiratory variables, and side effects in pediatric ..
  87. ncbi A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients
    Flavia Nobay
    Division of Emergency Medicine, Department of Internal Medicine, University of California, San Francisco, San Francisco, CA, USA
    Acad Emerg Med 11:744-9. 2004
    To determine if midazolam is superior to lorazepam or haloperidol in the management of violent and severely agitated patients in the emergency department...
  88. ncbi Efficacy of intrathecal midazolam with or without epidural methylprednisolone for management of post-herpetic neuralgia involving lumbosacral dermatomes
    G P Dureja
    Department of Pain Medicine, Indian Spinal Injuries Centre, New Delhi, India
    Pain Physician 13:213-21. 2010
    ..Recent studies have shown a promising anti nociceptive effect for intrathecal midazolam, a water soluble benzodiazepine, due to its interaction with benzodiazepine-GABA-A receptor complex within the ..
  89. pmc Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
    Marina Asiedu
    The University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 148:302-8. 2010
    ..Moreover, we demonstrate that spinal co-administration of ACT and midazolam (MZL) act synergistically to reduce neuropathic allodynia after peripheral nerve injury...
  90. ncbi Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries
    M Heinrich
    Department of Paediatric Surgery, Dr v Haunersches Kinderspital München, Munchen, Germany
    Eur J Pediatr Surg 14:235-9. 2004
    ..The goal of this study was to evaluate the off-label use of rectally administered S(+)-ketamine and Midazolam by paediatric surgeons during repeated outpatient dressing changes for paediatric burns and scalding.
  91. ncbi Pre-medication for bronchoscopy: a randomised double blind trial comparing alfentanil with midazolam
    Catherine M Houghton
    Department of Respiratory Medicine, Hope Hospital, Salford M6 8HD, UK
    Respir Med 98:1102-7. 2004
    This study was designed to compare the effects of alfentanil and midazolam pre-medication on patient comfort during and after flexible bronchoscopy...
  92. ncbi Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery
    A Apan
    Department of Anesthesiology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey
    Minerva Anestesiol 75:239-44. 2009
    This study aimed to evaluate the role of alfa-2 agonist infusion, with dexmedetomidine or midazolam, on hemodynamic and respiratory parameters while titrating the sedation level with the bispectral index (BIS) during cataract surgery.
  93. ncbi Comparison of midazolam, propofol and fentanyl combinations for sedation and hemodynamic parameters in cataract extraction
    Varol Celiker
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Saudi Med J 28:1198-203. 2007
    b>Midazolam, propofol and fentanyl were compared in terms of sedation during cataract extraction. Hemodynamic parameters, sedation level, postoperative satisfaction, and side effects were investigated.
  94. doi Midazolam inhibits tumor necrosis factor-alpha-induced endothelial activation: involvement of the peripheral benzodiazepine receptor
    Hee Kyoung Joo
    Department of Physiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Anesthesiology 110:106-12. 2009
    b>Midazolam is widely used as an intravenous sedative. However, the role of midazolam on vascular endothelial activation is still unknown...
  95. ncbi Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice
    Dora Farkas
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Clin Pharmacol 47:286-94. 2007
    ..13) with PJ (8 oz) did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg)...
  96. ncbi Bispectral index monitoring of conscious sedation with the combination of meperidine and midazolam during endoscopy
    Mohammed A Qadeer
    Section of Therapeutic Endoscopy, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 6:102-8. 2008
    ..Thus, we performed a prospective observational study to assess its ability for detecting deep sedation during endoscopy...
  97. ncbi Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery
    Mariska Y M Peeters
    Department of Clinical Pharmacy, St Antonius Hospital, The Netherlands
    Anesthesiology 105:1135-46. 2006
    Because information on the optimal dose of midazolam for sedation of nonventilated infants after major surgery is scant, a population pharmacokinetic and pharmacodynamic model is developed for this specific group.
  98. ncbi Sedation in uncooperative children undergoing dental procedures: a comparative evaluation of midazolam, propofol and ketamine
    Kavitha Rai
    Department of Pedodontics and Preventive Children Dentistry, A B Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India
    J Clin Pediatr Dent 32:1-4. 2007
    ..The efficacy and safety of conscious sedation, using intravenous short acting group of drugs (midazolam, propofol and ketamine) in uncooperative children, requiring oral rehabilitation was thus evaluated in this ..
  99. ncbi Sex differences in CYP3A activity using intravenous and oral midazolam
    Maylee Chen
    Ordway Research Institute Drug Development Center, Albany, NY 12206 1066, USA
    Clin Pharmacol Ther 80:531-8. 2006
    ..Our objective is to investigate whether sex differences exist in CYP3A activity as assessed by intravenous (IV) or oral midazolam pharmacokinetic analysis in healthy volunteers.
  100. ncbi Etomidate versus midazolam for procedural sedation in pediatric outpatients: a randomized controlled trial
    Lydia Di Liddo
    Division of Emergency Medicine, Department of Pediatrics, Centre Hospitalier Universitaire Ste Justine, Montreal, Quebec, Canada
    Ann Emerg Med 48:433-40, 440.e1. 2006
    b>Midazolam is widely used for procedural sedation and analgesia. Etomidate has been studied mostly in adults. Our objective is to compare the efficacy of etomidate and midazolam for achieving procedural sedation and analgesia in children.
  101. doi Efficacy of ketamine and midazolam as co-induction agents with propofol for laryngeal mask insertion in children
    Shiba Goel
    Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Paediatr Anaesth 18:628-34. 2008
    Use of midazolam and ketamine lowers the induction dose of propofol (co-induction) producing hemodynamic stability.

Research Grants81

  1. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth Ehrlich; Fiscal Year: 2009
    ..Genetic constructs and crosses will have to be produced and introduced into the backgroundof different ..
  2. A Resource for magnetic resonance and optical imaging
    Ravinder Reddy; Fiscal Year: 2009
    ..Brain Res 1016:20. Ferrarelli F, Haraldsson, MH, Barnhart TE, Roberts ADF, Massimini M, Stone CK, Kalin NH, Tononi G. (2004) A [17F]-fluoromethane PET/TMS study of effective connectivity. Brain Res Bull, 64:103. 1 ..
  3. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2012
    ..atropine to antagonize the action of excess acetylcholine formed at muscarinic receptors and 3) diazepam or midazolam to allosterically potentiate the action of inhibitory neurotransmitter -amino butyric acid (GABA) at GABAA ..
  4. Garlic Metabolism and Cytochrome P450 Modulation
    Danny Shen; Fiscal Year: 2007
    ..caffeine (1A2), buproprion (2B6), chlorzoxazone (2E1), tolbutamide (2C9), omeprazole (2C19), metoprolol (2D6), midazolam (3A4/5), and digoxin (Pgp), will be administered to a panel of healthy human volunteers at various times during ..
  5. Garlic Metabolism and Cytochrome P450 Modulation
    Danny Shen; Fiscal Year: 2006
    ..caffeine (1A2), buproprion (2B6), chlorzoxazone (2E1), tolbutamide (2C9), omeprazole (2C19), metoprolol (2D6), midazolam (3A4/5), and digoxin (Pgp), will be administered to a panel of healthy human volunteers at various times during ..
  6. Garlic Metabolism and Cytochrome P450 Modulation
    Danny Shen; Fiscal Year: 2005
    ..caffeine (1A2), buproprion (2B6), chlorzoxazone (2E1), tolbutamide (2C9), omeprazole (2C19), metoprolol (2D6), midazolam (3A4/5), and digoxin (Pgp), will be administered to a panel of healthy human volunteers at various times during ..
  7. Regulation of Cytokinesis and Tumor Formation by RhoA
    ANN LOUISE MILLER; Fiscal Year: 2010
    ..Learning more about the molecular mechanisms by which Rho activity regulates cytokinesis and tumorigenesis will advance our understanding of basic cell biology and could potentially identify new targets for cancer therapeutics. ..
  8. Characterization of Toxicity with Spinal Opiates
    Tony Yaksh; Fiscal Year: 2007
    ..Hypothesis 4. Clonidine (alpha2 agonist) and midazolam (benzodiazepine) suppress MC activation and this will diminish granuloma formation...
  9. Characterization of Toxicity with Spinal Opiates
    Tony Yaksh; Fiscal Year: 2009
    ..Hypothesis 4. Clonidine (alpha2 agonist) and midazolam (benzodiazepine) suppress MC activation and this will diminish granuloma formation...
  10. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..Hypothesis 4. Clonidine (alpha2 agonist) and midazolam (benzodiazepine) suppress MC activation and this will diminish granuloma formation...
  11. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2009
    ..of therapeutic hypothermia after cardiac arrest, the Merci'clot retriever for acute ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute ..
  12. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..pentobarbital, and isoflurane, and one customized injectable anesthetic protocol: etomidate/fentanyl/midazolam. These investigations will be accomplished in SCID mice bearing HT-29 colon carcinoma xenografts...
  13. Tumor NMR Images are Affected by Anesthetic
    VICTORIA LUKASIK; Fiscal Year: 2005
    ..pentobarbital, and isoflurane, and one customized injectable anesthetic protocol: etomidate/fentanyl/midazolam. These investigations will be accomplished in SCID mice bearing HT-29 colon carcinoma xenografts...
  14. Inflammation-induced changes in spinal GABA-A receptor signaling
    Michael S Gold; Fiscal Year: 2010
    ..However, our recent data also indicate that midazolam, a benzodiazepine receptor agonist, retains analgesic efficacy in the presence of inflammation, indicating that ..
  15. Inflammation-induced changes in spinal GABA-A receptor signaling
    Michael Gold; Fiscal Year: 2009
    ..However, our recent data also indicate that midazolam, a benzodiazepine receptor agonist, retains analgesic efficacy in the presence of inflammation, indicating that ..
  16. New York-Presbyterian NETT Consortium
    Stephan A Mayer; Fiscal Year: 2010
    ..of therapeutic hypothermia after cardiac arrest, the Merci'clot retriever for acute ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute ..
  17. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
    ..of therapeutic hypothermia after cardiac arrest, the Merci' clot retriever for acute ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute ..
  18. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2004
    ..Part 2: Semi-simultaneous oral:intravenous administration with midazolam to measure intestinal and hepatic contributions to CYP3A metabolism and Part 3: oral administration of ..
  19. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2003
    ..Part 2: Semi-simultaneous oral:intravenous administration with midazolam to measure intestinal and hepatic contributions to CYP3A metabolism and Part 3: oral administration of ..
  20. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2002
    ..Part 2: Semi-simultaneous oral:intravenous administration with midazolam to measure intestinal and hepatic contributions to CYP3A metabolism and Part 3: oral administration of ..
  21. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2005
    ..Part 2: Semi-simultaneous oral:intravenous administration with midazolam to measure intestinal and hepatic contributions to CYP3A metabolism and Part 3: oral administration of ..
  22. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1992
    ..four experiments will compare the effects of a range of doses of lorazepam with a range of doses of methyprylon, midazolam, flunitrazepam and several novel anxiolytics...
  23. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..four experiments will compare the effects of a range of doses of lorazepam with a range of doses of methyprylon, midazolam, flunitrazepam and several novel anxiolytics...
  24. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    ..and hepatic CYP3A4 through intravenous and oral administrations of a CYP3A-specific, in vivo catalytic probe -midazolam. The fentanyl arm of the study will 1) assess the effects of SJW on the brain uptake and efflux kinetics of ..
  25. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2001
    ..and hepatic CYP3A4 through intravenous and oral administrations of a CYP3A-specific, in vivo catalytic probe -midazolam. The fentanyl arm of the study will 1) assess the effects of SJW on the brain uptake and efflux kinetics of ..
  26. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2002
    ..and hepatic CYP3A4 through intravenous and oral administrations of a CYP3A-specific, in vivo catalytic probe -midazolam. The fentanyl arm of the study will 1) assess the effects of SJW on the brain uptake and efflux kinetics of ..
  27. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2004
    ..triazolam (Exp. 1); ketamine vs. midazolam (Exp. 2); and clonidine vs. alprazolam (Exp. 3)...
  28. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ..triazolam (Exp. 1); ketamine vs. midazolam (Exp. 2); and clonidine vs. alprazolam (Exp. 3)...
  29. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ..triazolam (Exp. 1); ketamine vs. midazolam (Exp. 2); and clonidine vs. alprazolam (Exp. 3)...
  30. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2005
    ..triazolam (Exp. 1); ketamine vs. midazolam (Exp. 2); and clonidine vs. alprazolam (Exp. 3)...
  31. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2003
    ..triazolam (Exp. 1); ketamine vs. midazolam (Exp. 2); and clonidine vs. alprazolam (Exp. 3)...
  32. Transplant Social Worker Support for Live Kidney Donation in African Americans
    LEIGH E BOULWARE; Fiscal Year: 2012
    ..This proposal will study two novel social worker led interventions (one behavioral, one financial) to improve live kidney donation for African Americans in need of a kidney transplant. ..
  33. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2000
    ..5 percent of neonates during NICU care or invasive procedures. A pilot randomized trial of morphine, midazolam, or placebo therapy in 69 preterm neonates showed reduced behavioral responses to pain and evidence of decreased ..
  34. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2001
    ..5 percent of neonates during NICU care or invasive procedures. A pilot randomized trial of morphine, midazolam, or placebo therapy in 69 preterm neonates showed reduced behavioral responses to pain and evidence of decreased ..
  35. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2000
    ..P450 activities will be determined using the drug probes chlorzoxazone for CYP2EI and midazolam for CYP3A4. Theophylline will be used for CYP1A2...
  36. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2002
    ..P450 activities will be determined using the drug probes chlorzoxazone for CYP2EI and midazolam for CYP3A4. Theophylline will be used for CYP1A2...
  37. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..P450 activities will be determined using the drug probes chlorzoxazone for CYP2EI and midazolam for CYP3A4. Theophylline will be used for CYP1A2...
  38. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2001
    ..P450 activities will be determined using the drug probes chlorzoxazone for CYP2EI and midazolam for CYP3A4. Theophylline will be used for CYP1A2...
  39. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2004
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
  40. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2003
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
  41. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2001
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
  42. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2000
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
  43. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2002
    ..of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress response...
  44. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2003
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  45. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2000
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  46. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2004
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  47. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2001
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  48. Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)
    Roland R Griffiths; Fiscal Year: 2010
    ..by evaluating a range of intramuscularly administered doses of ketamine relative to intramuscularly administered midazolam as the comparison standard...
  49. Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)
    ROLAND GRIFFITHS; Fiscal Year: 2007
    ..by evaluating a range of intramuscularly administered doses of ketamine relative to intramuscularly administered midazolam as the comparison standard...
  50. Human Clinical Pharmacology of Emerging Drugs of Abuse (Club Drugs)
    ROLAND GRIFFITHS; Fiscal Year: 2009
    ..by evaluating a range of intramuscularly administered doses of ketamine relative to intramuscularly administered midazolam as the comparison standard...
  51. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2002
    ..antagonist, proves to be insensitive to increasing doses of muscimol, the binding of the benzodiazepine agonist midazolam will be used as a probe for GABAA-R function by measuring the displacement of 11C-FMZ by midazolam...
  52. APPLICATIONS OF PHARMACOKINETICS IN CLINICAL PSYCHIATRY
    Richard Shader; Fiscal Year: 1992
    ..days of therapy, subjects will receive a test-dose challenge with a short half-life benzodiazepine (intravenous midazolam, 0.04 mg/kg, oral triazolam, 0.25 mg, or placebo)...
  53. APPLICATIONS OF PHARMACOKINETICS IN CLINICAL PSYCHIATRY
    Richard Shader; Fiscal Year: 1990
    ..days of therapy, subjects will receive a test-dose challenge with a short half-life benzodiazepine (intravenous midazolam, 0.04 mg/kg, oral triazolam, 0.25 mg, or placebo)...
  54. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2004
    ....
  55. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2003
    ....
  56. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2005
    ....
  57. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2001
    ....
  58. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2002
    ....
  59. BENZODIAZEPINE EFFECTS ON OPERANT BEHAVIOR
    JOSEPH MOERSCHBAECHER; Fiscal Year: 1990
    ..the acute effects of "long: (diazepam, flurazepam), "intermediate" (lorazepam, oxazepam), and "short" (midazolam, triazolam) acting benzodiazepines on learning and performance will be determined...
  60. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 1999
    ..5 percent of neonates during NICU care or invasive procedures. A pilot randomized trial of morphine, midazolam, or placebo therapy in 69 preterm neonates showed reduced behavioral responses to pain and evidence of decreased ..
  61. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCE
    ALFRED WOLF; Fiscal Year: 1990
    ..for new therapeutic drugs, will begin with the synthesis of positron emitter labeled drugs such as (11C) midazolam, a recently introduced benzodiazepine receptor active drug used in pre-anesthetic sedation...
  62. Oxidized-LDL, LOX-1 and angiogenesis
    JAWAHAR MEHTA; Fiscal Year: 2009
    ..Information from this study may be important in understanding the development of atherosclerosis and certain cancers that are dependent of angiogenesis. ..
  63. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2012
    ..We propose to explore combinations of the following drugs: 1/ Midazolam, a GABAA receptor agonist which is easily delivered intra-muscularly...
  64. Effect of Cirrhosis and Shunts on Drug Disposition
    J Gorski; Fiscal Year: 2003
    ..in hepatic clearance, cirrhotic patients with TIPS experience an increase in intestinal availability of midazolam, a selective cytochrome P450 3A (CYP3A) substrate...
  65. Effect of Cirrhosis and Shunts on Drug Disposition
    J Gorski; Fiscal Year: 2002
    ..in hepatic clearance, cirrhotic patients with TIPS experience an increase in intestinal availability of midazolam, a selective cytochrome P450 3A (CYP3A) substrate...
  66. AGING EFFECT ON DRUG BIOAVAILABILITY
    Stephen Hall; Fiscal Year: 1999
    ..intestinal availability, intestinal intrinsic clearance, hepatic availability and hepatic intrinsic clearance of midazolam will be quantified in young and elderly, male and female human volunteers...
  67. Effect of Cirrhosis and Shunts on Drug Disposition
    J Gorski; Fiscal Year: 2004
    ..in hepatic clearance, cirrhotic patients with TIPS experience an increase in intestinal availability of midazolam, a selective cytochrome P450 3A (CYP3A) substrate...
  68. Effect of Cirrhosis and Shunts on Drug Disposition
    J Gorski; Fiscal Year: 2005
    ..in hepatic clearance, cirrhotic patients with TIPS experience an increase in intestinal availability of midazolam, a selective cytochrome P450 3A (CYP3A) substrate...
  69. ANESTHETICS' MECHANISMS OF ACTION--PRESYNAPTIC SITES
    M MacIver; Fiscal Year: 1993
    ..The actions of six clinically used anesthetics (halothane, isoflurane, sevoflurane, pentobarbital, propofol and midazolam) will be compared on five independent measures of presynaptic function...
  70. Sleep Intervention During Acute Lung Injury
    Sairam Parthasarathy; Fiscal Year: 2010
    ..strategies: central 12 adrenergic sedative-analgesic (dexmedetomidine) versus a conventional sedation strategy (midazolam and fentanyl) in a randomized, double blind, cross-over study...
  71. Sleep Intervention During Acute Lung Injury
    Sairam Parthasarathy; Fiscal Year: 2009
    ..strategies: central 12 adrenergic sedative-analgesic (dexmedetomidine) versus a conventional sedation strategy (midazolam and fentanyl) in a randomized, double blind, cross-over study...
  72. ORAL BENZODIAZEPINE SELF ADMINISTRATION
    RICHARD MEISCH; Fiscal Year: 1999
    ..Thus, a training or acquisition procedure is necessary. With midazolam a fading procedure was used whereby increasing amounts of drug were added to an ethanol solution (that was ..
  73. ORAL BENZODIAZEPINE SELF ADMINISTRATION
    RICHARD MEISCH; Fiscal Year: 1999
    ..Thus, a training or acquisition procedure is necessary. With midazolam a fading procedure was used whereby increasing amounts of drug were added to an ethanol solution (that was ..
  74. Genetic and Other Determinants of In Vivo CYP3A Activity
    GRANT WILKINSON; Fiscal Year: 2002
    ..Drugs with different metabolic characteristics and routes of administration (midazolam, triazolam and alprazolam) will be used to test this hypothesis...
  75. EFFECT OF NASAL FENTANYL ON POSTANESTHETIC BEHAVIOR IN CHILDREN
    Jeffrey Galinkin; Fiscal Year: 1999
    ..etiology of this adverse emergence behavior is unclear, though age of < 6 years and the use of sevoflurane, midazolam and atropine may be predisposing factors...