temazepam

Summary

Summary: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Top Publications

  1. ncbi Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance
    Michel A Paul
    Toronto laboratories of Defence Research and Development Canada, Toronto, Ontario, Canada
    Aviat Space Environ Med 74:1263-70. 2003
  2. ncbi Adverse effects of temazepam in older adults with chronic insomnia
    Charles M Morin
    Universite Laval, Quebec, Canada
    Hum Psychopharmacol 18:75-82. 2003
  3. ncbi The effects of restricting publicly subsidised temazepam capsules on benzodiazepine use among injecting drug users in Australia
    Courtney L Breen
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Med J Aust 181:300-4. 2004
  4. ncbi Usefulness of temazepam and zaleplon to induce afternoon sleep
    Ries Simons
    TNO Human Factors, Aerospace Medicine Group, P O Box 23, 3769 ZG Soesterberg, The Netherlands
    Mil Med 171:998-1001. 2006
  5. doi Highway driving in the elderly the morning after bedtime use of hypnotics: a comparison between temazepam 20 mg, zopiclone 7.5 mg, and placebo
    Tim R M Leufkens
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:432-8. 2009
  6. ncbi Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study
    Annabel H Nickol
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    J Sleep Res 15:445-54. 2006
  7. ncbi A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep
    M O Karlsson
    Department of Pharmacy, Uppsala University, Sweden
    Clin Pharmacol Ther 68:175-88. 2000
  8. ncbi Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam
    Michel A Paul
    Defence Research and Development Canada Toronto, North York, Ontario, Canada
    Aviat Space Environ Med 75:512-9. 2004
  9. ncbi Privileging pleasure: temazepam injection in a heroin marketplace
    Robyn Dwyer
    National Drug Research Institute, Curtin University of Technology, Perth, Australia
    Int J Drug Policy 19:367-74. 2008
  10. ncbi Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia
    M Partinen
    Haaga Neurological Research Centre NEURO, Department of Clinical Neurosciences, University of Helsinki, Mäkipellontie 15, FIN 00320 Helsinki, Finland
    Sleep Med 4:553-61. 2003

Detail Information

Publications184 found, 100 shown here

  1. ncbi Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance
    Michel A Paul
    Toronto laboratories of Defence Research and Development Canada, Toronto, Ontario, Canada
    Aviat Space Environ Med 74:1263-70. 2003
    ..g., zopiclone, temazepam (t(1/2) 4-6 hours) may be used...
  2. ncbi Adverse effects of temazepam in older adults with chronic insomnia
    Charles M Morin
    Universite Laval, Quebec, Canada
    Hum Psychopharmacol 18:75-82. 2003
    ..Benzodiazepine-hypnotics are frequently used for treating insomnia in older adults; however, there is little information about adverse effects associated with their usage over several weeks, particularly in this segment of the population...
  3. ncbi The effects of restricting publicly subsidised temazepam capsules on benzodiazepine use among injecting drug users in Australia
    Courtney L Breen
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Med J Aust 181:300-4. 2004
    To assess the effect of a restriction on publicly subsidised temazepam 10 mg capsules upon the injection of benzodiazepines by injecting drug users (IDUs).
  4. ncbi Usefulness of temazepam and zaleplon to induce afternoon sleep
    Ries Simons
    TNO Human Factors, Aerospace Medicine Group, P O Box 23, 3769 ZG Soesterberg, The Netherlands
    Mil Med 171:998-1001. 2006
    ..The usefulness of temazepam and zaleplon to optimize afternoon sleep and their effects on performance and alertness during a subsequent ..
  5. doi Highway driving in the elderly the morning after bedtime use of hypnotics: a comparison between temazepam 20 mg, zopiclone 7.5 mg, and placebo
    Tim R M Leufkens
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:432-8. 2009
    ..The aim of this study was to evaluate the residual effects the morning after evening doses of temazepam 20 mg and zopiclone 7.5 mg on driving performance in healthy elderly drivers...
  6. ncbi Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study
    Annabel H Nickol
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    J Sleep Res 15:445-54. 2006
    The aim of the study was to examine the efficacy and safety of temazepam on nocturnal oxygenation and next-day performance at altitude. A double-blind, randomized, cross-over trial was performed in Thirty-three healthy volunteers...
  7. ncbi A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep
    M O Karlsson
    Department of Pharmacy, Uppsala University, Sweden
    Clin Pharmacol Ther 68:175-88. 2000
    ..A hypnogram shows how sleep travels through its various stages in the course of a night. The sleep stage changes can be quantified to study sedative drug effects...
  8. ncbi Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam
    Michel A Paul
    Defence Research and Development Canada Toronto, North York, Ontario, Canada
    Aviat Space Environ Med 75:512-9. 2004
    ..Current military operations often require pharmaceutical methods to sustain alertness and facilitate sleep in order to maintain operational readiness. This study was designed to compare the sleep-inducing power of four medications...
  9. ncbi Privileging pleasure: temazepam injection in a heroin marketplace
    Robyn Dwyer
    National Drug Research Institute, Curtin University of Technology, Perth, Australia
    Int J Drug Policy 19:367-74. 2008
    Pleasure and its pursuit provide the key explanatory frame in this ethnographic analysis of temazepam injection among a set of drug injectors who enthusiastically embrace high-risk practices...
  10. ncbi Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia
    M Partinen
    Haaga Neurological Research Centre NEURO, Department of Clinical Neurosciences, University of Helsinki, Mäkipellontie 15, FIN 00320 Helsinki, Finland
    Sleep Med 4:553-61. 2003
    ..Occasionally, insomniac patients may take a sleeping pill after midnight. This may have consequences on their ability to drive a car and result in an increased risk of car accidents...
  11. ncbi Effect of low-dose temazepam on physiological variables and performance tests following a westerly flight across five time zones
    T Reilly
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    Int J Sports Med 22:166-74. 2001
    ..before retiring to bed on days 1, 2 and 3, subjects were administered, in a double-blind fashion, either 10mg of temazepam or a placebo...
  12. ncbi Selective effects of clonidine and temazepam on attention and memory
    Brian Tiplady
    Department of Anaesthesia, Intensive Care, and Pain Medicine, University of Edinburgh, Edinburgh, UK
    J Psychopharmacol 19:259-65. 2005
    The present study compared the effects of clonidine and temazepam on performance on a range of tasks aiming to assess the role of central noradrenergic mechanisms in cognitive function...
  13. ncbi Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects
    Jennifer R Glass
    Division of Clinical Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    J Clin Psychopharmacol 23:260-8. 2003
    ..crossover, placebo-controlled study was performed to assess the comparative pharmacodynamics of single doses of temazepam (15 and 30 mg), diphenhydramine (50 and 75 mg), and valerian (400 and 800 mg) in 14 healthy elderly volunteers (..
  14. ncbi Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions
    S Verheyen
    Laboratorium voor Farmacotechnologie en Biofarmacie, K U Leuven, Campus Gasthuisberg O N, Herestraat 49, 3000, Leuven, Belgium
    Int J Pharm 249:45-58. 2002
    ..relationship between their physico-chemical properties and dissolution characteristics, pure drugs (diazepam, temazepam), polymer (PEG6000), solid dispersions and physical mixtures were characterised by DSC, X-ray powder diffraction ..
  15. ncbi Improving daytime sleep with temazepam as a countermeasure for shift lag
    J Lynn Caldwell
    U S Army Aeromedical Research Laboratory, Fort Rucker, AL, USA
    Aviat Space Environ Med 74:153-63. 2003
    ..When the shift must be worked several consecutive nights, a cumulative sleep debt is created. Appropriate countermeasures are required to help personnel obtain as much sleep as possible so they may perform their duties effectively...
  16. ncbi Efficacy of temazepam in frequent users: a series of N-of-1 trials
    A C M Wegman
    Institute for Research in Extramural Medicine, Department of General Practice, VU University Medical Center, Amsterdam, The Netherlands
    Fam Pract 22:152-9. 2005
    ..Benzodiazepines are frequently prescribed for sleep disturbances. However, benzodiazepines are associated with side effects, and may be ineffective when used for a prolonged period of time...
  17. ncbi Neurobehavioural performance effects of daytime melatonin and temazepam administration
    Naomi L Rogers
    Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Sleep Res 12:207-12. 2003
    ..present study compared neurobehavioural performance following administration of melatonin and the benzodiazepine temazepam, using a within-subjects design...
  18. ncbi [Adverse renal effects of legal and illicit drugs]
    S R Orth
    Abteilung für Nephrologie Hypertonie, Inselspital, Bern
    Ther Umsch 59:122-30. 2002
    ..Thus, in any case of unexplained renal functional impairment substance abuse should be considered by the physician...
  19. ncbi Toward evidence-based prescribing at end of life: a comparative review of temazepam and zolpidem for the treatment of insomnia
    Kevin T Bain
    excelleRx, Inc, Philadelphia, Pennsylvania, USA
    Am J Hosp Palliat Care 20:382-8. 2003
    A comparative review of temazepam and zolpidem use in managing insomnia in the hospice patient was undertaken to determine whether treatment with temazepam is a more cost-effective approach for this patient population...
  20. ncbi Insomnia. Diagnosis and management
    Ron Grunstein
    Sleep Research Group, Institute of Respiratory Medicine, University of Sydney
    Aust Fam Physician 31:995-1000. 2002
    ..Insomnia is a complaint of perceived poor sleep quality resulting in impairment of daytime function. It is the commonest clinical sleep disorder with approximately 6-12% of adults complaining of chronic insomnia...
  21. ncbi [Signopam treatment of insomnia in patients with somatic pathology]
    L V Romasenko
    Zh Nevrol Psikhiatr Im S S Korsakova 104:60-1. 2004
  22. ncbi CNS effects of sumatriptan and rizatriptan
    S D Silberstein
    Cephalalgia 24:78; author reply 78-9. 2004
  23. ncbi Comparison of the rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and tamazepam-glucuronide catalyzed by E. coli beta-D-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer
    C Dou
    Roche Diagnostic Corporation, Indianapolis, IN 46250, USA
    J Forensic Sci 46:335-40. 2001
    The catalytic rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide, and temazepam-glucuronide when catalyzed by E. Coli...
  24. ncbi CNS effects of sumatriptan and rizatriptan in healthy female volunteers
    J van der Post
    Centre for Human Drug Research, Leiden, The Netherlands
    Cephalalgia 22:271-81. 2002
    This study investigates the CNS effects of sumatriptan and rizatriptan, with temazepam as an active comparator, in healthy female volunteers...
  25. ncbi Zolpidem is not superior to temazepam with respect to rebound insomnia: a controlled study
    Richard C Oude Voshaar
    Department of Psychiatry, University Medical Centre St Radboud hp 333, P O Box 9101, 6500 HB Nijmegen, Netherlands
    Eur Neuropsychopharmacol 14:301-6. 2004
    This randomised controlled trial was conducted to compare zolpidem to an equivalent dose of temazepam with respect to subjective rebound insomnia after cessation of 4 weeks of treatment in chronic insomnia (zolpidem 10 mg, n=79; ..
  26. ncbi Comparison of temazepam 7.5 mg with temazepam 15 mg for the treatment of transient insomnia
    Milton K Erman
    Pacific Sleep Medicine Services, San Diego, CA 92121, USA
    Curr Med Res Opin 20:441-9. 2004
    To demonstrate the equivalent efficacy of temazepam 7.5 mg and temazepam 15 mg for the treatment of transient insomnia.
  27. ncbi Severe vein damage caused by Temezepam injecting
    Campbell K Aitken
    Aust N Z J Public Health 26:79. 2002
  28. ncbi Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine
    Carol L O'Neal
    J Forensic Sci 47:427-8. 2002
  29. ncbi Behavioral treatment for chronic insomnia
    J Todd Arnedt
    Department of Psychiatry and Human Behavior, Box G BH, Brown University, Providence, RI 02912, USA
    Med Health R I 85:90-4. 2002
  30. ncbi Evaluation of actigraphy and automated telephoned questionnaires to assess hypnotic effects in insomnia
    S J Wilson
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Bristol, UK
    Int Clin Psychopharmacol 19:77-84. 2004
    ..took part in a 5-week, double-blind, placebo-controlled study of the effects of 2 weeks of administration of temazepam 20 mg on sleep. Outcome measures were actigraphy and daily St Mary's Hospital Sleep Questionnaires (SMHSQ)...
  31. ncbi Acute performance-impairing and subject-rated effects of triazolam and temazepam, alone and in combination with ethanol, in humans
    Cathy A Simpson
    Department ofPsychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, USA
    J Psychopharmacol 16:23-34. 2002
    The acute behavioural effects of triazolam (0.125 and 0.25 mg), temazepam (15 and 30 mg), and placebo, alone and in combination with ethanol (0 and 0.5 g/kg), were assessed in 10 volunteers...
  32. ncbi Are changes in beliefs and attitudes about sleep related to sleep improvements in the treatment of insomnia?
    C M Morin
    Ecole de Psychologie, Universite Laval, Sainte Foy, Quebec, Canada
    Behav Res Ther 40:741-52. 2002
    ..These findings highlight the importance of targeting sleep-related beliefs and attitudes in the treatment of insomnia...
  33. ncbi Digit loss following misuse of temazepam
    Gerald F X Feeney
    Alcohol and Drug Assessment Unit, Princess Alexandra Hospital, Woolloongabba, QLD
    Med J Aust 176:380. 2002
  34. ncbi Use of night-time benzodiazepines in an elderly inpatient population
    M Ramesh
    Department of Pharmacy Practice, JSS College of Pharmacy, S S Nagara, Mysore, India
    J Clin Pharm Ther 27:93-7. 2002
    ..Secondary objectives included assessment of quality of sleep in hospital compared with home and monitoring for possible benzodiazepine side-effects...
  35. ncbi Images in emergency medicine. Activated charcoal aspiration
    Jason B Hack
    Brody School of Medicine, Department of Emergency Medicine, Greenville, NC, USA
    Ann Emerg Med 48:522, 531. 2006
  36. ncbi The effect of melatonin on sedation of children undergoing magnetic resonance imaging
    M R J Sury
    Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br J Anaesth 97:220-5. 2006
    ..Melatonin may induce a natural sleepiness and improve predictability of sedation drugs. We have investigated its clinical value in children sedated for magnetic resonance imaging...
  37. ncbi Altitude insomnia: studies during an expedition to the Himalayas
    A N Nicholson
    Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire, England
    Sleep 11:354-61. 1988
    ..At high altitude (4,150-4,846 m), each subject ingested temazepam (10 mg) for one night and placebo for another...
  38. ncbi Hypnotic residual effects of benzodiazepines with repeated administration
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202
    Sleep 9:309-16. 1986
    ..Twelve healthy, normal sleepers received flurazepam 30 mg, temazepam 30 mg, and placebo for nine nights in a repeated measures, Latin-square design with 19 nights of recovery ..
  39. ncbi Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly
    Juha Puustinen
    Department of Family Medicine, University of Turku, Turku, Finland
    Drugs Aging 24:1045-59. 2007
    ..To describe associations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities and cognitive function in the elderly...
  40. pmc Conducting research in individual patients: lessons learnt from two series of N-of-1 trials
    Anke C M Wegman
    Department of Pharmacology Pharmacotherapy, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    BMC Fam Pract 7:54. 2006
    ..These difficulties are described and our solutions are discussed...
  41. ncbi The effect of temazepam on respiration in elderly insomniacs with mild sleep apnea
    M E Camacho
    Division of Geriatric Medicine, Medical College of Virginia/Virginia Commonwealth University, USA
    Sleep 18:644-5. 1995
    This study evaluated the respiratory effect of temazepam in elderly subjects (mean age 65 +/- 3.8 years), with mild sleep apnea...
  42. ncbi Visual hallucination and temazepam: an unusual case
    Abid Iraqi
    J Am Geriatr Soc 54:1627-8. 2006
  43. ncbi Suppression of chiral recognition of 3-hydroxy-1,4-benzodiazepines during micellar electrokinetic capillary chromatography with bile salts
    S Boonkerd
    Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Belgium
    J Chromatogr A 704:238-41. 1995
    ..peak splitting and broadening were observed for some 3-hydroxy-1,4-benzodiazepines (oxazepam, lorazepam, temazepam and lormetazepam)...
  44. ncbi Nurse led sedation for paediatric MRI: progress and issues
    Claire Woodthorpe
    Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Paediatr Nurs 19:14-8. 2007
    ..This article describes the current magnetic resonance imaging (MRI) sedation service, the role of the nurse sedationist, results of clinical audits, and future issues within MRI...
  45. doi The effects of the market withdrawal of temazepam gel capsules on benzodiazepine injecting in Sydney, Australia
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    Drug Alcohol Rev 27:145-51. 2008
    This study assessed the impact on benzodiazepine injection among IDU in Sydney of removing temazepam gel capsule preparations from the Australian market.
  46. ncbi The detection of sedatives in hair and nail samples using tandem LC-MS-MS
    Rachel C Irving
    Department of Chemistry, The University of Waikato, Knighton Road, Hamilton, New Zealand
    Forensic Sci Int 166:58-67. 2007
    Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction ..
  47. ncbi Modeling cumulative dose and exposure duration provided insights regarding the associations between benzodiazepines and injuries
    Michal Abrahamowicz
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Clin Epidemiol 59:393-403. 2006
    ..We propose new methods for modeling various aspects of medication use history and employment of them to assess the adverse effects of selected benzodiazepines...
  48. doi Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial
    Jennifer R Glass
    Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 28:182-8. 2008
    A randomized, controlled, crossover clinical study compared 14-night treatment with 15 mg temazepam, 50 mg diphenhydramine, and placebo in elderly individuals with insomnia (mean age, 73.9 years; range, 70-89 years)...
  49. ncbi Alcohol and other drug use in later life
    Moira G Sim
    Centre for Postgraduate Medicine, Edith Cowan University, Western Australia
    Aust Fam Physician 33:820-4. 2004
    ..Drug use in the elderly is associated with significant morbidity anid can be masked by other medical problems...
  50. ncbi Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice
    Joanna Listos
    Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Staszica 4, 20 081 Lublin, Poland
    Eur J Pharmacol 523:71-8. 2005
    ..0 or 60.0 mg/kg, s.c.) with flumazenil (10.0 mg/kg, i.p.) in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes...
  51. ncbi The effect of single oral doses of zopiclone on nocturnal melatonin secretion in healthy male volunteers
    T R Norman
    Department of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 25:825-33. 2001
    The effects of single oral doses of zopiclone and temazepam were investigated in eight healthy male volunteers using a single blind, placebo controlled cross over study. Doses of zopiclone were 7...
  52. ncbi Fatigue in military aviation: an overview of US military-approved pharmacological countermeasures
    John A Caldwell
    Biosciences and Protection Division, United States Air Force Research Laboratory, Brooks City Base, TX 78235, USA
    Aviat Space Environ Med 76:C39-51. 2005
    ..S. military have authorized the use of specific compounds for this purpose. Hypnotics such as temazepam, zolpidem, or zaleplon can mitigate the fatigue associated with insufficient or disturbed sleep...
  53. ncbi Premedication for bronchoscopy in older patients: a double-blind comparison of two regimens
    M R Watts
    Department of Medicine for the Elderly Medical Day Ward, Limerick Regional Hospital, Dooradoyle, Co Limerick, Ireland
    Respir Med 99:220-6. 2005
    ..We compared a novel premedication regimen-oral temazepam plus nebulised Lignocaine (new treatment) to an established regimen of intravenous alfentanyl (control).
  54. ncbi Periodic movements of the legs during sleep associated with rises in systemic blood pressure
    N J Ali
    Osler Chest Unit, Churchill Hospital, Headington, Oxford
    Sleep 14:163-5. 1991
    ..Following treatment with temazepam, the swings in blood pressure were unchanged despite considerably less electroencephalographic evidence of ..
  55. ncbi Separation of oxazepam, lorazepam, and temazepam enantiomers by HPLC on a derivatized cyclodextrin-bonded phase: application to the determination of oxazepam in plasma
    Chuong Pham-Huy
    Laboratory of Toxicology, Faculty of Pharmacy, University of Paris V, 4 avenue de l Observatoire, 75006 Paris, France
    J Biochem Biophys Methods 54:287-99. 2002
    ..liquid chromatography (HPLC) of three racemic 3-hydroxybenzodiazepines, oxazepam (Oxa), lorazepam (Lor), and temazepam (Tem), is a difficult operation because of the spontaneous chiral inversion in polar solvent...
  56. ncbi High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma
    Yuzhong Deng
    Discovery MAP Group, Bristol Myers Squibb Company, Wilmington, DE 19880, USA
    Rapid Commun Mass Spectrom 16:1116-23. 2002
    ..The method was cross-validated with a conventional liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay...
  57. ncbi Quantitation of drug metabolites in the absence of pure metabolite standards by high-performance liquid chromatography coupled with a chemiluminescence nitrogen detector and mass spectrometer
    Yuzhong Deng
    PCO, Bristol Myers Squibb Company, P O Box 4000, Princeton, NJ 08543, USA
    Rapid Commun Mass Spectrom 18:1681-5. 2004
    ..For this evaluation, oxazepam and temazepam were chosen as a 'drug/metabolite' pair. Temazepam was treated as the methylated metabolite of oxazepam...
  58. ncbi Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma
    Hang Zeng
    Discovery MAP Group, Bristol Myers Squibb Company, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 788:331-7. 2003
    ..An evaluation of this system was performed using a mixture of fenfluramine, temazepam, oxazepam, and tamoxifen in plasma. A total cycle time of 1...
  59. ncbi Selectivity in the generalization profile in baboons trained to discriminate lorazepam: benzodiazepines, barbiturates and other sedative/anxiolytics
    N A Ator
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 282:1442-57. 1997
    ..8 mg/kg). Triazolam, alprazolam, diazepam, midazolam, bromazepam, temazepam and nordiazepam occasioned >80% of total responses on the lorazepam-paired lever, in that order of potency, ..
  60. ncbi [Benzodiazepines and forensic aspects]
    L Michel
    Praticien Hospitalier, Chef de Service SMPR, EPS Charcot, 30, Avenue Marc Laurent, BP 20, 78373 Plaisir cedex
    Encephale 29:479-85. 2003
    ..benzodiazepines have already been identified for this use: flunitrazepam, clorazepate but also triazolam and temazepam in UK, alprazolam in USA. Flunitrazepam is prohibited in USA and considered as narcotics in France...
  61. ncbi A validated method for simultaneous screening and quantification of twenty-three benzodiazepines and metabolites plus zopiclone and zaleplone in whole blood by liquid-liquid extraction and ultra-performance liquid chromatography- tandem mass spectrometry
    Kirsten Wiese Simonsen
    Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, 3 DK 2100, Denmark
    J Anal Toxicol 34:332-41. 2010
    ..7-aminoflunitrazepam, lorazepam, lormetazepam, midazolam, nitrazepam, 7-aminonitrazepam, oxazepam, temazepam, triazolam, zaleplon, and zopiclone. Whole blood from drug-free volunteers was used for all experiments...
  62. ncbi Determination of benzodiazepines in oral fluid using LC-MS-MS
    Christine Moore
    Immunalysis Corporation, 829 Towne Center Drive, Pomona, California 91767, USA
    J Anal Toxicol 31:596-600. 2007
    ..clonazepam, lorazepam, oxazepam, diazepam, midazolam, flurazepam, flunitrazepam, nordiazepam, triazolam, temazepam, nitrazepam, and chlordiazepoxide in oral fluid is described, using liquid chromatography coupled to a triple ..
  63. ncbi Experience with urine drug testing by the Correctional Service of Canada
    A D Fraser
    Queen Elizabeth II Health Sciences Centre and Dalhousie University, 1278 Tower Road, Halifax, NS, Canada B3H 2Y9
    Forensic Sci Int 121:16-22. 2001
    ..7%), morphine (3.2%), cocaine metabolite (3.2%), codeine (2.6%), oxazepam (2.1%), temazepam (1.1%) and ethyl alcohol (1.0%). In correctional institutions (8606 non-dilute specimens analyzed in 1999), 16...
  64. ncbi Urine benzodiazepine screening using Roche Online KIMS immunoassay with beta-glucuronidase hydrolysis and confirmation by gas chromatography- mass spectrometry
    Kevin L Klette
    Navy Drug Screening Laboratory, 320 B Street, Great Lakes, Illinois 60088 2815, USA
    J Anal Toxicol 29:193-200. 2005
    ..With hydrolysis, temazepam, oxazepam, and lorazepam glucuronides, produced cross-reactivities of 25%, 15%, and 20%, respectively...
  65. ncbi Anticholinergic activity of 107 medications commonly used by older adults
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, Geriatric Psychopharmacology Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1333-41. 2008
    ..Citalopram, escitalopram, fluoxetine, lithium, mirtazapine, quetiapine, ranitidine, and temazepam had values less than 5 pmol/mL...
  66. ncbi Effect of benzodiazepines on tryptophan binding to rat hepatic nuclei
    H Sidransky
    Department of Pathology, George Washington University Medical Center, Washington, D C 20037
    Toxicol Pathol 20:350-6. 1992
    ..that the addition of chlordiazepoxide, diazepam, prazepam, flurazepam, nordazepam, N-desalkylflurazepam, temazepam, oxazepam, lorazepam, or 4-chlorodiazepam has little influence on the L-(5-3H) tryptophan binding to hepatic ..
  67. ncbi Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry
    Marion Villain
    Laboratoire ChemTox, rue Grüninger, 67400 Illkirch, France
    J Chromatogr B Analyt Technol Biomed Life Sci 825:72-8. 2005
    ..7-aminoflunitrazepam, bromazepam, clobazam, diazepam, lorazepam, lormetazepam, midazolam, nordiazepam, oxazepam, temazepam, tetrazepam, triazolam, zaleplon and zolpidem)...
  68. ncbi Quetiapine for insomnia associated with refractory depression exacerbated by phenelzine
    Kenneth N Sokolski
    Mood Disorders Clinic, Veterans Affairs Long Beach Healthcare System, Long Beach, CA 90822, USA
    Ann Pharmacother 40:567-70. 2006
    ..To report the successful treatment of phenelzine-associated insomnia with low-dose quetiapine in a patient with refractory depression...
  69. ncbi Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds
    Roland R Griffiths
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Clin Psychiatry 66:31-41. 2005
    ..methaqualone, diazepam, flunitrazepam, lorazepam, GHB (gamma-hydroxybutyrate, also known as sodium oxybate), temazepam, zaleplon, eszopiclone, triazolam, zopiclone, flurazepam, zolpidem, oxazepam, estazolam, diphenhydramine, ..
  70. ncbi The use of sedative/hypnotic medication and its correlation with falling down in the hospital
    W B Mendelson
    Sleep Research Laboratory, University of Chicago, IL 60637, USA
    Sleep 19:698-701. 1996
    ..Orally administered benzodiazepines that were significantly associated with falls included temazepam, alprazolam, diazepam, and lorazepam, but not triazolam, chlordiazepoxide, or chlorazepate...
  71. ncbi Management of insomnia
    C K Kirkwood
    School of Pharmacy, Virginia Commonwealth University, Richmond 23298 0533, USA
    J Am Pharm Assoc (Wash) 39:688-96; quiz 713-4. 1999
    ..To review current issues in the pharmacologic and nonpharmacologic management of insomnia...
  72. ncbi Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Anal Toxicol 31:424-33. 2007
    ..Multiple combinations of diazepam, nordiazepam, oxazepam, temazepam, chlordiazepoxide, and lorazepam were reported for the Benzodiazepine Group...
  73. ncbi Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies
    Russell P Rosenberg
    Northside Hospital Sleep Medicine Institute, Atlanta, GA, USA
    Ann Clin Psychiatry 18:49-56. 2006
    ..When insomnia is recognized, considerable emphasis has been placed on improving sleep onset; however, there is growing evidence that improving sleep maintenance is an equally important treatment goal...
  74. doi Can improving sleep influence sleep-disordered breathing?
    Frederic Series
    Centre de Pneumologie Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada
    Drugs 69:77-91. 2009
    ..The benzodiazepines flurazepam, temazepam and nitrazepam, the hypnotic zolpidem, the melatonin receptor agonist ramelteon and gamma-hydroxybutyrate have ..
  75. ncbi Simultaneous analysis of 14 benzodiazepines in oral fluid by solid-phase extraction and LC-MS-MS
    George Ngwa
    Chemistry, Lehigh University, 6 E Packer Ave, Seeley G Mudd Building, Bethlehem, Pennsylvania 18015, USA
    J Anal Toxicol 31:369-76. 2007
    ..The target compounds include diazepam, oxazepam, temazepam, nordiazepam, lorazepam, chlordiazepoxide, alprazolam, alpha-hydroxyalprazolam, desalkylflurazepam, ..
  76. ncbi Residual effects of hypnotics: epidemiology and clinical implications
    Annemiek Vermeeren
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, Universiteitssingel 40, PO Box 616, ER 6229 Maastricht, The Netherlands
    CNS Drugs 18:297-328. 2004
    ..of residual effects of 11 hypnotics (flunitrazepam, flurazepam, loprazolam, lormetazepam, midazolam, nitrazepam, temazepam, triazolam, zaleplon, zolpidem and zopiclone) was derived from expert ratings, a meta-analysis and actual ..
  77. ncbi Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites
    T H Rushmore
    Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Metab Eng 2:115-25. 2000
    ..18 mg). Diazepam (100 microM, 2.9 mg/100 ml), added to a 100-ml CYP3A4 bioreactor, was converted to temazepam (1.1 mg), N-demethyldiazepam (0.35 mg), and oxazepam (0.15 mg). Diclofenac (100 microM, 3...
  78. doi Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay
    Sarah J Glover
    Department of Clinical Biochemistry, Leeds Teaching Hospitals NHS Trust, Britannia House, Morley, Leeds LS27 0DQ, UK
    Ann Clin Biochem 47:111-7. 2010
    ....
  79. ncbi An evaluation of the diagnostic accuracy of liquid chromatography-tandem mass spectrometry versus immunoassay drug testing in pain patients
    Amadeo Pesce
    Millennium Laboratories Research Institute, San Diego, CA 92127, USA
    Pain Physician 13:273-81. 2010
    ..Because clinical use of pain medications is different from illicit drug use, there is a need to evaluate the level of diagnostic accuracy of this procedure for the pain patient...
  80. ncbi Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: a cross-sectional study
    Helka M V Hosia-Randell
    Research and Development Unit for Medical Education, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Drugs Aging 25:683-92. 2008
    ....
  81. ncbi Metabolism of diazepam and related benzodiazepines by human liver microsomes
    W D Hooper
    Department of Medicine, University of Queensland, Brisbane, Australia
    Eur J Drug Metab Pharmacokinet 17:51-9. 1992
    ..Formation of temazepam gave a curved profile over the same range of diazepam concentrations, suggestive of a sigmoidal relationship...
  82. ncbi Quantitation of benzodiazepines in whole blood by electron impact-gas chromatography-mass spectrometry
    Nicholas B Tiscione
    Palm Beach County Sheriff s Office, 3228 Gun Club Road, West Palm Beach, Florida 33406, USA
    J Anal Toxicol 32:644-52. 2008
    ..and common use in the United States and include diazepam, desalkylflurazepam, nordiazepam, midazolam, oxazepam, temazepam, lorazepam, clonazepam, and alprazolam (relative elution order). The linear range (r2 > 0...
  83. ncbi Hepatotrophic activity of benzodiazepine drugs in adult rats of either sex
    L L Gershbein
    Biochemical Laboratories, John F Kennedy Health Care Corporation, Chicago, Illinois 60634
    Res Commun Mol Pathol Pharmacol 85:83-104. 1994
    ..activity was higher with lorazepam, loprazolam, oxazepam and chlordiazepoxide; intermediate with nitrazepam, temazepam, quazepam, halazepam and triazepam and lower with diazepam, clorazepate dipotassium, clobazam and alprazolam...
  84. ncbi A rapid CZE method for the analysis of benzodiazepines in spiked beverages
    Rebecca Webb
    Centre for Forensic Science, Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, NSW, Australia
    Electrophoresis 28:3553-65. 2007
    ..determination of nine benzodiazepines in spiked beverages (nitrazepam oxazepam, alprazolam, flunitrazepam, temazepam, diazepam, 7-aminoflunitrazepam, 7-aminonitrazepam and 7-aminoclonazepam)...
  85. ncbi Comparison of molecularly imprinted solid-phase extraction (MISPE) with classical solid-phase extraction (SPE) for the detection of benzodiazepines in post-mortem hair samples
    Robert A Anderson
    Forensic Medicine and Science, University of Glasgow, Joseph Black Building, University Place, Glasgow G12 8QQ, Scotland
    Forensic Sci Int 174:40-6. 2008
    ..Both extraction methods detected diazepam, nordiazepam, oxazepam, temazepam and nitrazepam in the samples...
  86. ncbi Melatonin and zopiclone: the relationship between sleep propensity and body temperature
    Alexandra L Holmes
    Centre for Sleep Research, University of South Australia, Woodville
    Sleep 25:301-6. 2002
    The sleep promoting effects of the sedative-hypnotics, melatonin and temazepam, have been associated with a decline in core body temperature (Tc)...
  87. ncbi Stability of benzodiazepines and cocaine in blood spots stored on filter paper
    Abdulkareem A Alfazil
    Forensic Medicine and Science, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Anal Toxicol 32:511-5. 2008
    ..The drugs selected included flunitrazepam, temazepam, oxazepam, lorazepam, nitrazepam, diazepam, and cocaine...
  88. ncbi Development of a nurse-led sedation service for paediatric magnetic resonance imaging
    M R Sury
    Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Lancet 353:1667-71. 1999
    ..We have therefore developed a nurse-led sedation service in a designated unit next to the scanner. This study assessed the safety and efficacy of this approach...
  89. ncbi Achiral and chiral separations using MEKC, polyelectrolyte multilayer coatings, and mixed mode separation techniques with molecular micelles
    Candace A Luces
    Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA
    Electrophoresis 31:1036-43. 2010
    ..In the case of chiral separations, temazepam, aminoglutethimide, benzoin, benzoin methyl ether, and coumachlor were separated using the three separation ..
  90. ncbi Interaction of alcohol and drugs in fatal poisonings
    Anna Koski
    Laboratory of Toxicology, Department of Forensic Medicine, FIN 00014, University of Helsinki, Finland
    Hum Exp Toxicol 22:281-7. 2003
    ..When levomepromazine, temazepam or zopiclone were present, the median BAC was also significantly lower, 2.5-2.7 percent per thousand...
  91. ncbi [Determination of diazepam and its metabolites in serum by the use of liquid chromatography-mass spectrometry method]
    Snezana Dordević
    Vojnomedicinska akademija, Nacionalni centar za kontrolu trovanja, Odeljenje za toksikolosku hemiju, Beograd, Srbija
    Vojnosanit Pregl 64:659-62. 2007
    ..of diazepam takes place in liver which generates pharmacologically active metabolites N-desmethyldiazepam, temazepam and oxazepam...
  92. ncbi High level benzodiazepine and ammonia clearance by flat membrane bioreactors with porcine liver cells
    A Bader
    Leibniz Institute for Biotechnology and Artificial Organs, Division of Thoracic and Cardio Surgery, Medizinische Hochschule Hannover, Podbielskistr 380, D 30659, Hannover, Germany
    J Biotechnol 81:95-105. 2000
    ..Typical diazepam metabolites including temazepam, N-desmethyl-diazepam and oxazepam were generated...
  93. ncbi Rapid analysis of metabolites and drugs of abuse from urine samples by desorption electrospray ionization-mass spectrometry
    Tiina J Kauppila
    Department of Chemistry, 560 Oval Drive, Purdue University, West Lafayette, IN 47907 2084, USA
    Analyst 132:868-75. 2007
    ..oxymorphone, 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol, Delta(9)-tetrahydrocannabinol, alprazolam, temazepam, oxazepam, N-desmethyldiazepam (nordiazepam) and hydroxytemazepam...
  94. ncbi Liquid chromatography/quadrupole ion trap/time-of-flight determination of the efficacy of drug test kits for rapid screening of food
    Jessica B Zuckschwerdt
    Commonwealth of Virginia, Division of Consolidated Laboratory Services, Richmond, Virginia 23219, USA
    J Food Prot 71:1007-14. 2008
    ..2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, imipramine, doxepin, nitrazepam, diazepam, oxazepam, temazepam, alprazolam, flunitrazepam, clonazepam, and lorazepam...
  95. doi Enzyme-assisted synthesis and structural characterization of pure benzodiazepine glucuronide epimers
    T Pallmann
    Institute of Legal Medicine, University Hospital of Cologne, Melatengürtel 60 62, D 50823 Cologne, Germany
    Eur J Pharm Sci 39:233-40. 2010
    The three hydroxybenzodiazepines oxazepam, temazepam, and lorazepam used for their anxiolytic, sedative, and anticonvulsant properties are metabolized by glucuronidation, which is the predominant pathway in the clearance mechanism of ..
  96. ncbi Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
    M V St-Pierre
    Faculty of Pharmacy, University of Toronto, Canada
    J Pharmacol Exp Ther 265:1437-45. 1993
    ..The concomitant C3-hydroxylation of DZ to temazepam, which can also be N-demethylated to form OZ, was minimal...
  97. doi Determination of diazepam and its metabolites in human urine by liquid chromatography/tandem mass spectrometry using a hydrophilic polymer column
    Hironobu Umezawa
    Department of Legal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Rapid Commun Mass Spectrom 22:2333-41. 2008
    Diazepam and its major metabolites, nordazepam, temazepam and oxazepam, in human urine samples, were analyzed by liquid chromatography (LC)/tandem mass spectrometry (MS/MS) using a hydrophilic polymer column (MSpak GF-310 4B), which ..
  98. ncbi Free drug metabolic clearance in elderly people
    Jennifer M Butler
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Clin Pharmacokinet 47:297-321. 2008
    ..There is some indirect evidence for reduced clearance of the highly protein-bound drugs oxaprozin, temazepam, lorazepam, diazepam, phenytoin and warfarin, although studies measuring free concentrations are lacking...
  99. ncbi Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes
    H O Jauregui
    Department of Pathology and Oncology, Rhode Island Hospital, Providence
    Xenobiotica 21:1091-106. 1991
    ..in isolated liver microsomes) and in cultured cells (up to 100% and 400% increases in the formation of temazepam and nordiazepam, respectively, after 25 days in culture)...
  100. doi An in vitro approach to estimate putative inhibition of buprenorphine and norbuprenorphine glucuronidation
    Stephanie Oechsler
    Institute of Legal Medicine and Traffic Medicine, University Hospital, Voss Str 2, 69115, Heidelberg, Germany
    Int J Legal Med 124:187-94. 2010
    ..glucuronidation, substrates were incubated with drugs (amitriptyline, nortriptyline, lamotrigine, oxazepam, and temazepam), which are extensively cleared by glucuronidation as well as are often used during maintenance treatment...
  101. ncbi Tolerability of hypnosedatives in older patients
    Udo Wortelboer
    Department of Psychiatry and Psychotherapy, Sleep Research Center, Georg August University of Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Drugs Aging 19:529-39. 2002
    ..For some substances (e.g. zolpidem, zopiclone, zaleplon, temazepam and triazolam) the recommended dosage is half that recommended for younger patients...

Research Grants87

  1. ABUSE LIABILITY OF COMMONLY PRESCRIBED HYPNOTICS
    CRAIG RUSH; Fiscal Year: 1999
    ..hypnotics, like triazolam, have a greater abuse liability than low-potency benzodiazepine hypnotics, like temazepam and flurazepam. Novel compounds like zolpidem may also have less abuse liability...
  2. COG-BEHAVIOR & PHARMACOTHERAPY FOR LATE-LIFE INSOMNIA
    Charles Morin; Fiscal Year: 1990
    ..and randomly assigned to one of the following conditions: (a) cognitive-behavior therapy; (b) pharmacotherapy (temazepam); (c) cognitive-behavior therapy plus pharmacotherapy; (d) drug-placebo; and (e) waiting-list...
  3. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2003
    ....
  4. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2001
    ....
  5. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2004
    ....
  6. Cognitive-Behavior Therapy for Insomnia: Component Analysis & Treatment Mechanism
    Charles Morin; Fiscal Year: 2008
    ..The long-term objective is to contribute to the development and dissemination of evidence-based treatments for chronic insomnia and its common comorbidities. ..
  7. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2002
    ....
  8. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2005
    ....
  9. Cognitive-Behavior Therapy for Insomnia: Component Analysis & Treatment Mechanism
    Charles Morin; Fiscal Year: 2007
    ..The long-term objective is to contribute to the development and dissemination of evidence-based treatments for chronic insomnia and its common comorbidities. ..
  10. Cognitive-Behavior Therapy for Insomnia: Component Analysis & Treatment Mechanism
    Charles Morin; Fiscal Year: 2009
    ..The long-term objective is to contribute to the development and dissemination of evidence-based treatments for chronic insomnia and its common comorbidities. ..
  11. Cognitive-Behavior Therapy for Insomnia: Component Analysis & Treatment Mechanism
    Charles M Morin; Fiscal Year: 2010
    ..The long-term objective is to contribute to the development and dissemination of evidence-based treatments for chronic insomnia and its common comorbidities. ..
  12. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 2000
    ..This research should contribute to efforts to develop new classes of sedative-anxiolytic compounds which have reduced potential for abuse by drug abusers as well as reduced potential for inappropriate chronic use among patients. ..
  13. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1992
    ..More generally, the data will contribute to an understanding of anziolytic-sedative drug abuse and will ultimately contribute to development of improved prevention, control and treatment procedures...
  14. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2000
    ....
  15. BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMS
    ROLAND GRIFFITHS; Fiscal Year: 1999
    ..Ultimately, these data may also contribute to the development of improved drug abuse treatment strategies and to the development of anxiolytic/hypnotic compounds with reduced memory-impairing potential. ..
  16. Neural Correlates of Language and Communication in Apes
    William D Hopkins; Fiscal Year: 2010
    ..Overall, the proposed research will lead a better understanding of factors which influence the development of the central nervous system and its behavioral and communicative correlates. ..
  17. Hemispheric Specialization and Communication
    William Hopkins; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2004
    ....
  19. LICIT & ILLICIT ABUSED STIMULANT DRUGS
    ROLAND GRIFFITHS; Fiscal Year: 1999
    ..abstract_text> ..
  20. Hemispheric Specialization and Communication
    William D Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  21. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 1991
    ..Two experiments will investigate optimal conditions for maintaining maximal intravenous and oral caffine self- administration and one experiment will characterize spontaneous withdrawal effects after high chronic doses of caffine...
  22. BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMS
    ROLAND GRIFFITHS; Fiscal Year: 2001
    ..Ultimately, these data may also contribute to the development of improved drug abuse treatment strategies and to the development of anxiolytic/hypnotic compounds with reduced memory-impairing potential. ..
  23. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ....
  24. NEUROBIOLOGY OF HEMISPHERIC SPECIALIZATION IN PRIMATES
    William Hopkins; Fiscal Year: 2005
    ..The overall studies will contribute to our understanding of factors that influence individual and species differences in the expression of hemispheric specialization. ..
  25. Neural Correlates of Language and Communication in Apes
    William D Hopkins; Fiscal Year: 2010
    ..Overall, the proposed research will lead a better understanding of factors which influence the development of the central nervous system and its behavioral and communicative correlates. ..
  26. Abuse Liability Associated with Chronic Hypnotic Use
    Timothy Roehrs; Fiscal Year: 2005
    ....
  27. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  28. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2006
    ..Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population. ..
  29. SLEEPINESS AND THE REINFORCING EFFECT OF METHYLPHENIDATE
    Timothy Roehrs; Fiscal Year: 1999
    ..And finally during year five the interaction of behavioral demand placed on subjects and different levels of sleepiness-alertness will be the focus. ..
  30. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2005
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  31. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 1992
    ..Two experiments will investigate optimal conditions for maintaining maximal intravenous and oral caffine self- administration and one experiment will characterize spontaneous withdrawal effects after high chronic doses of caffine...
  32. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2005
    ....
  33. Insomnia as a Path to Alcohol Abuse
    Timothy Roehrs; Fiscal Year: 2005
    ..abstract_text> ..
  34. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2007
    ..In addition, these data have implications for sleep homeostasis and for the public health implications for adolescent sleep schedules. ..
  35. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2009
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  36. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2009
    ..In addition, these data have implications for sleep homeostasis and for the public health implications for adolescent sleep schedules. ..
  37. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2008
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  38. Abuse Liability Associated with Chronic Hypnotic Use
    Timothy Roehrs; Fiscal Year: 2008
    ....
  39. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2008
    ..In addition, these data have implications for sleep homeostasis and for the public health implications for adolescent sleep schedules. ..
  40. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2004
    ..Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population. ..
  41. LICIT & ILLICIT ABUSED STIMULANT DRUGS
    ROLAND GRIFFITHS; Fiscal Year: 2001
    ..abstract_text> ..
  42. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2001
    ....
  43. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..More generally, the data will contribute to an understanding of anziolytic-sedative drug abuse and will ultimately contribute to development of improved prevention, control and treatment procedures...
  44. BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMS
    ROLAND GRIFFITHS; Fiscal Year: 2000
    ..Ultimately, these data may also contribute to the development of improved drug abuse treatment strategies and to the development of anxiolytic/hypnotic compounds with reduced memory-impairing potential. ..
  45. SLEEPINESS AND THE REINFORCING EFFECT OF METHYLPHENIDATE
    Timothy Roehrs; Fiscal Year: 2000
    ..And finally during year five the interaction of behavioral demand placed on subjects and different levels of sleepiness-alertness will be the focus. ..
  46. ANALYSIS OF INTRAVENOUS DRUG SELF-ADMINISTRATION
    ROLAND GRIFFITHS; Fiscal Year: 1980
    ..Another set of studies will use a discrete-trial choice procedure to explore the influence of a series of mixed agonist/antagonists on intravenous heroin reinforcement...
  47. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1990
    ..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
  48. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1991
    ....
  49. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1990
    ....
  50. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2003
    ..Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population. ..
  51. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2003
    ....
  52. LICIT & ILLICIT ABUSED STIMULANT DRUGS
    ROLAND GRIFFITHS; Fiscal Year: 2003
    ..abstract_text> ..
  53. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
  54. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ....
  55. Insomnia as a Path to Alcohol Abuse
    Timothy Roehrs; Fiscal Year: 2002
    ..abstract_text> ..
  56. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ....
  57. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1992
    ..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
  58. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2010
    ..In addition, these data have implications for sleep homeostasis and for the public health implications for adolescent sleep schedules. ..
  59. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2009
    ..Either a positive or negative result will expand knowledge of the neurophysiology of this disorder. A positive result could be of diagnostic or prognostic value. ..
  60. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2005
    ..Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population. ..
  61. Longitudinal measurements of sleep EEG in adolescence
    Irwin Feinberg; Fiscal Year: 2002
    ..Our studies will also provide benchmark data for neurodevelopmental studies in psychiatrically ill adolescents and 'at-risk' population. ..