devazepide

Summary

Summary: A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.

Top Publications

  1. ncbi Devazepide fails to reverse the inhibitory effect of interleukin-1beta on food intake in female rats
    Peter C Butera
    Department of Psychology, Niagara University, P O Box 2208, Niagara, NY 14109 2208, USA
    Physiol Behav 82:777-83. 2004
  2. ncbi Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth
    Jaime Carrillo
    Laboratorio de Genética y Patología Molecular de Tumores Sólidos Infantiles, Departamento de Biología Molecular y Celular del Cáncer, Instituto de Investigaciones Biomédicas A Sols CSIC UAM, Madrid 28029, Spain
    Anticancer Drugs 20:527-33. 2009
  3. ncbi Different role of cholecystokinin (CCK)-A and CCK-B receptors in relapse to morphine dependence in rats
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 200032, Shanghai, People s Republic of China
    Behav Brain Res 120:105-10. 2001
  4. ncbi Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats
    Lin Lu
    Kailuan Mental Health Center, Tangshan 063001, China
    Brain Res 954:132-40. 2002
  5. ncbi Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
    R A Cowles
    Department of Surgery, University of Michigan, 2920B Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0331, USA
    Regul Pept 99:61-8. 2001
  6. ncbi Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R389-98. 2003
  7. ncbi Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors
    J Glatzle
    University Hospital, Department of General and Transplantation Surgery, , , Germany
    Am J Physiol Regul Integr Comp Physiol 281:R222-9. 2001
  8. ncbi Abdominal vagal mediation of the satiety effects of CCK in rats
    Roger D Reidelberger
    Department of Veterans Affairs Nebraska Western Iowa Health Care System, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1005-12. 2004
  9. ncbi Role of cholecystokinin in the gastric motor response to a meal in horses
    Mireia Lorenzo-Figueras
    Island Whirl Equine Colic Research Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Am J Vet Res 67:1998-2005. 2006
  10. ncbi Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isogami dori, Chuo Ku, Kobe, 651 0084, Japan
    Regul Pept 141:8-11. 2007

Research Grants

  1. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 2001
  2. MECHANISMS UNDERLYING MATERNAL CALMING AND ANALGESIA
    ELLIOTT BLASS; Fiscal Year: 1993
  3. IL-lB and Meal Patterns: Ovarian Hormones and CCK
    PETER BUTERA; Fiscal Year: 2002
  4. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
  5. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
  6. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008

Detail Information

Publications150 found, 100 shown here

  1. ncbi Devazepide fails to reverse the inhibitory effect of interleukin-1beta on food intake in female rats
    Peter C Butera
    Department of Psychology, Niagara University, P O Box 2208, Niagara, NY 14109 2208, USA
    Physiol Behav 82:777-83. 2004
    ..The present experiment examined the ability of the CCK(A) receptor antagonist devazepide to block the effects of IL-1 and estradiol on food intake in female rats...
  2. ncbi Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth
    Jaime Carrillo
    Laboratorio de Genética y Patología Molecular de Tumores Sólidos Infantiles, Departamento de Biología Molecular y Celular del Cáncer, Instituto de Investigaciones Biomédicas A Sols CSIC UAM, Madrid 28029, Spain
    Anticancer Drugs 20:527-33. 2009
    ..Here, we analyzed the impact of two CCK receptor antagonists, devazepide (a CCK1-R antagonist) and L365 260 (a CCK2-R antagonist), on the growth of Ewing tumor cells...
  3. ncbi Different role of cholecystokinin (CCK)-A and CCK-B receptors in relapse to morphine dependence in rats
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 200032, Shanghai, People s Republic of China
    Behav Brain Res 120:105-10. 2001
    ..These findings suggest that CCK-B receptor antagonists might be of some value in the treatment and prevention of relapse to drug dependence long after detoxification...
  4. ncbi Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats
    Lin Lu
    Kailuan Mental Health Center, Tangshan 063001, China
    Brain Res 954:132-40. 2002
    The effects of different cholecystokinin (CCK) receptor antagonists (devazepide and L365,260) on cocaine or stress-induced reactivation of cocaine conditioned place preference (CPP) were investigated in rats...
  5. ncbi Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
    R A Cowles
    Department of Surgery, University of Michigan, 2920B Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0331, USA
    Regul Pept 99:61-8. 2001
    ..CART peptide likely acts upon either peripheral or central regulators of pancreatic secretory function that are distant from the acinar unit...
  6. ncbi Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R389-98. 2003
    ..Fasted rats with open gastric fistulas received devazepide (1 mg/kg iv) or A-70104 (700 nmol. kg(-1). h(-1) iv) and either a 30-min intravenous infusion of CCK-8 (10 nmol...
  7. ncbi Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors
    J Glatzle
    University Hospital, Department of General and Transplantation Surgery, , , Germany
    Am J Physiol Regul Integr Comp Physiol 281:R222-9. 2001
    ..Taken together with the results of the food intake studies, this suggests that activation of CCK-A receptors is involved in the postprandial activation of NTS neurons and in the regulation of food intake...
  8. ncbi Abdominal vagal mediation of the satiety effects of CCK in rats
    Roger D Reidelberger
    Department of Veterans Affairs Nebraska Western Iowa Health Care System, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1005-12. 2004
    ..b>Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt of N alpha-3-quinolinoyl-D-Glu-N,N-..
  9. ncbi Role of cholecystokinin in the gastric motor response to a meal in horses
    Mireia Lorenzo-Figueras
    Island Whirl Equine Colic Research Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Am J Vet Res 67:1998-2005. 2006
    ....
  10. ncbi Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isogami dori, Chuo Ku, Kobe, 651 0084, Japan
    Regul Pept 141:8-11. 2007
    ..These results indicated that elevated CCK may contribute to anorexic and anxious phenotype of PP overexpressing mice...
  11. ncbi Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Shih Pai, Taipei 11221, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 367:406-13. 2003
    ..The selective CCK(1) receptor antagonists, devazepide and lorglumide, effectively attenuated the OT-induced inhibition of gastric emptying and gastrointestinal ..
  12. ncbi Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice
    Michael M Chi
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1044-53. 2004
    ..Moreover, devazepide prevented this suppression, indicating this increased sensitivity was mediated by CCK-1 receptors...
  13. ncbi Effects of peripheral CCK receptor blockade on food intake in rats
    Roger D Reidelberger
    Department of Veterans Affairs, Nebraska Western Iowa Health Care System, Omaha 68105, USA
    Am J Physiol Regul Integr Comp Physiol 285:R429-37. 2003
    ..At dark onset, non-food-deprived rats received a bolus injection of devazepide (2...
  14. ncbi Molecular cloning of an unusual bicistronic cholecystokinin receptor mRNA expressed in chicken brain: a structural and functional expression study
    Isabelle B M Nilsson
    Strategic Development LMO, Molecular Biology Laboratory, University Hospital, Linköping S 581 85, Sweden
    Regul Pept 114:37-43. 2003
    ..agonists (CCK-8, CCK-4, gastrin-17), whereas CCK-CHR showed higher affinity for the CCK-A receptor antagonist, devazepide, than for the CCK-B receptor antagonist, L-365,260...
  15. ncbi Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents
    Robert C Ritter
    Am J Physiol Regul Integr Comp Physiol 286:R991-3. 2004
  16. ncbi Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway
    J Glatzle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Physiol Regul Integr Comp Physiol 287:R354-9. 2004
    ..was significantly reduced by 77 and 55%, respectively, in rats treated with the CCK(1) receptor blocker devazepide or after functional vagal deafferentation by perineural capsaicin treatment...
  17. ncbi Vagal afferent responses to fatty acids of different chain length in the rat
    S Lal
    Department of Gastro-Intestinal Sciences, Hope Hospital, Salford M6 8HD, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 281:G907-15. 2001
    ..The effect of oleate was abolished by the CCK-A receptor antagonist Devazepide (0...
  18. ncbi Soybean beta-conglycinin peptone suppresses food intake and gastric emptying by increasing plasma cholecystokinin levels in rats
    Takashi Nishi
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 133:352-7. 2003
    ..The suppression of food intake by beta-conglycinin peptone was abolished by an intravenous injection of devazepide, a selective peripheral CCK receptor antagonist...
  19. ncbi The soybean beta-conglycinin beta 51-63 fragment suppresses appetite by stimulating cholecystokinin release in rats
    Takashi Nishi
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 133:2537-42. 2003
    ..These results indicate that the beta-conglycinin beta 51-63 fragment is the bioactive appetite suppressant in beta-conglycinin, and multiple arginine residues in the fragment may be involved in this effect...
  20. ncbi Intermolecular interactions between peptidic and nonpeptidic agonists and the third extracellular loop of the cholecystokinin 1 receptor
    Craig Giragossian
    Department of Chemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Med Chem 46:3476-82. 2003
    ..The proposed binding modes of GI5269 and GI0122 are supported by the structure-activity relationship of analogues and mutagenesis data for the CCK(1)-R selective antagonist L-364,718...
  21. ncbi L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats
    A Shemyakin
    Department of Biological Sciences, Fordham University, Bronx, New York 10458, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1420-6. 2001
    ..These results suggest that endogenous CCK, acting on CCK-A receptors, may play a key role in eliciting postprandial sleep...
  22. ncbi Mediators of glucagon-like peptide 2-induced blood flow: responses in different vascular sites
    Mustafa Deniz
    Marmara University School of Medicine, Department of Physiology, 34668 Haydarpasa, Istanbul, Turkey
    Regul Pept 142:7-15. 2007
    ..Our results also suggest that the stimulatory effect of GLP-2 on SMA blood flow is NO-dependent and mediated via intrinsic, non-cholinergic enteric neurons...
  23. ncbi Effects of peripheral CCK receptor blockade on gastric emptying in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R66-75. 2003
    Type A CCK receptor (CCKAR) antagonists differing in blood-brain barrier permeability [devazepide penetrates; the dicyclohexylammonium salt of Nalpha-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-70104) does not] were used to test the ..
  24. pmc PEGylated cholecystokinin prolongs satiation in rats: dose dependency and receptor involvement
    I Verbaeys
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium
    Br J Pharmacol 152:396-403. 2007
    ..The present study assessed the dose-dependency of this response and the effect of two selective CCK(1) receptor antagonists, with different abilities to cross the blood-brain barrier (BBB), on PEG-CCK(9)-induced anorexia...
  25. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats
    C L Wu
    Dept of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Scand J Gastroenterol 37:1133-9. 2002
    ..The effects of estradiol benzoate (EB) on gastric emptying, gastrointestinal transit and plasma levels of cholecystokinin (CCK) were studied in ovariectomized rats...
  26. ncbi Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats
    Jerome Gay
    Neuro Gastroenterology and Nutrition Unit, Institut National de la Recherche, Agronomique, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex, France
    Brain Behav Immun 17:35-42. 2003
    ..Thus, in our experimental conditions, i.e., within 30-50 days post-N. brasiliensis infection, we observed an enhancement of the anorectic effect of exogenous CCK involving mast cell degranulation and histamine...
  27. ncbi Intestinal transit of fat depends on accelerating effect of cholecystokinin and slowing effect of an opioid pathway
    Henry C Lin
    Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    Dig Dis Sci 47:2217-21. 2002
    ..1 mg/kg devazepide (a peripheral CCK-A-receptor antagonist) administered intraluminally and intravenously, respectively...
  28. ncbi Distinct receptors for cholecystokinin and gastrin on canine fundic D-cells
    J Delvalle
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109
    Am J Physiol 264:G811-5. 1993
    ..These studies delineate the presence of distinct CCK-A and CCK-B/gastrin receptors on canine fundic D-cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. pmc Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat
    A J Gaw
    Peptic Ulceration Group, Pharmacology I, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 115:660-4. 1995
    ..the pressor response and bradycardia elicited by sCCK-8 were reduced by the selective CCKA receptor antagonists, devazepide (0.5-50 nmol kg-1) and lorglumide (1-7 mumol kg-1)...
  30. ncbi Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats
    Jelena Pupovac
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2
    J Nutr 132:2775-80. 2002
    ..The CCK-A receptor antagonist, devazepide (which reverses protein-induced food intake suppression), when given at 0.25 mg/kg, i.p...
  31. ncbi Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum
    M Storr
    Department of Internal Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Neuropharmacology 44:524-32. 2003
    ..1%), devazepide (10(-8) M: +19.4%; 10(-7) M: +30.0%) and SR-27897 (10(-10) M: +21.8%, 10(-8) M: +47.0%, P<0.05, n=8)...
  32. pmc Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin
    M Blackmore
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 66:32-8. 1992
    ..6 x 10(-5) M) and the CCK-A receptor antagonist devazepide (1...
  33. ncbi Cholecystokinin-8S-induced intracellular calcium signaling in acutely isolated periaqueductal gray neurons of the rat
    Yu Mi Yang
    Biomedical Research Center, Korea Institute of Science and Technology KIST, Seoul, Korea
    Biol Pharm Bull 30:297-302. 2007
    ..The evidence presented here expands our understanding of cellular mechanisms for CCK-mediated anti-analgesic and anxiogenic actions in the PAG...
  34. ncbi Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene
    J Dunlop
    Biochemistry Laboratory, Wyeth Research UK Ltd, Taplow, Maidenhead
    Neuropeptides 30:359-63. 1996
    ..CCK-8S > CI988 > PD 135158 > pentagastrin > CCK-8NS > L-365,260 > CCK-4 > LY 288513 > devazepide > A71378 > lorglumide) was found to be in excellent agreement with CCK-B receptor pharmacology described ..
  35. pmc Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations
    S Koks
    Department of Physiology, University of Tartu, Estonia, Männistö
    J Psychiatry Neurosci 25:33-42. 2000
    ..Differences in the anxiety levels of rats in summer and winter, and the role of CCK in these behavioural alterations, were also examined...
  36. ncbi Endogenous oxytocin excites phasic contraction of gallbladder in rabbits through oxytocin receptor
    Chuan Yong Liu
    Institute of Physiology, Medical School of Shandong University, Jinan, Shandong, PR China
    Chin J Physiol 46:95-101. 2003
    ..We suggest that endogenous OT regulates gallbladder phasic contraction through specific OT receptor. This effect is independent of the peripheral CCK and M receptors...
  37. ncbi Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rat
    Cherese N Sullivan
    Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1071-80. 2007
    ..Similar to CCK-8, devazepide, a specific CCK(1) receptor antagonist, and not L365,260, a specific CCK(2) receptor antagonist, attenuated the ..
  38. pmc The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat
    N J Hayward
    Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
    Br J Pharmacol 104:973-7. 1991
    ..5. The selective CCKA antagonist, devazepide, was inactive at up to 300 mumol kg-1 i.p. against the three stimulants of acid secretion. 6...
  39. ncbi A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus
    M Corsi
    Glaxo Research Laboratories, Verona, Italy
    J Pharmacol Exp Ther 270:734-40. 1994
    ..The selective CCK-A antagonist L-364,718 (Devazepide) antagonized both types of contraction with a pKB of 10.10 and 9.95, respectively...
  40. ncbi An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats
    Daniela M Sartor
    Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Regul Integr Comp Physiol 290:R625-33. 2006
    ..Alternatively, animals were pretreated with the CCK1 receptor antagonists devazepide and lorglumide or the 5-HT3 antagonist MDL-72222 before SO-SBTI administration...
  41. ncbi Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback
    K L Whited
    Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA 95616, USA
    Endocrinology 148:4695-703. 2007
    ..inhibited gastric emptying of a chow meal in wild-type but not A-IV(-/-) mice andCCK(1)R receptor blockade with devazepide (10 microg/100 g), abolished PYY(3-36)-induced inhibition of gastric emptying...
  42. ncbi Secretion of pancreatic digestive enzymes induced in rats by first-time oral exposure to kidney bean E2L2 lectin is mediated only in part by cholecystokinin (CCK)
    G Grant
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Pancreas 19:382-9. 1999
    ..Additional mechanisms or hormones, such as secretin, may play a role in modulating later exocrine pancreas responses to PHA...
  43. pmc Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs
    Jie Zhu
    Department of Gastroenterology, Renmin Hospital and Research Center of Structural Biology, Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 16:1076-85. 2010
    ..To investigate the effects of sulfated cholecystokinin octapeptide (CCK-8S) on the contractile activity of guinea-pig proximal colon...
  44. ncbi Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin
    G Flemstrom
    Department of Neuroscience, Uppsala University, Sweden
    Acta Physiol (Oxf) 201:141-50. 2011
    ..We have investigated the effects of apelin peptides on duodenal bicarbonate secretion in vivo and the release of cholecystokinin (CCK) from acutely isolated mucosal cells and the neuroendocrine cell line STC-1...
  45. ncbi Influence of cholecystitis state on pharmacological response to cholecystokinin of isolated human gallbladder with gallstones
    María A Martínez-Cuesta
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Dig Dis Sci 48:898-905. 2003
    ....
  46. ncbi [The effects of cholecystokinin octapeptide on PKC activity in rat cerebral cortex neurocytes]
    Peng Xiang
    Lab of Hormone receptor, Department of Biochemistry, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 33:72-4, 120. 2002
    ..To investigate the effects of CCK8 on protein kinase C activity in rat cerebral cortex...
  47. pmc Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice
    Yuki Orikawa
    Central Research Laboratories, Zeria Pharmaceutical Co, Ltd, 2512 1 Numagami, Oshikiri, Kumagaya shi, Saitama, Japan
    Mol Pain 6:72. 2010
    ....
  48. pmc A potential gastrointestinal link between enhanced postnatal maternal care and reduced anxiety-like behavior in adolescent rats
    Brittany C Weber
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Behav Neurosci 123:1178-84. 2009
    ..e., devazepide)...
  49. ncbi Cholecystokinin reduces ethanol consumption in golden hamsters
    David Dibattista
    Brock University, Department of Psychology, St Catharines, Ontario, Canada L2S 3A1
    Alcohol 29:173-81. 2003
    ..Findings are consistent with the notion that endogenous CCK plays a key role in the short-term control of ethanol intake in hamsters...
  50. ncbi The subfornical organ: a novel site of action of cholecystokinin
    Al Shaimaa F Ahmed
    Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada and
    Am J Physiol Regul Integr Comp Physiol 306:R363-73. 2014
    ..SFO neurons in vivo to CCK (16 μg/kg ip), in the presence and absence of CCK₁ or CCK₂ receptor antagonists (devazepide; 600 μg/kg and L-365,260; 100 μg/kg, respectively), using the functional activation markers c-Fos and ..
  51. pmc Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY
    Brenna M Flannery
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA
    Toxicol Sci 130:289-97. 2012
    ..Food intake experiments using the NPY2 receptor antagonist BIIE0246 and the CCK1A receptor antagonist devazepide, individually, suggested that PYY mediated DON-induced anorexia but CCK did not...
  52. pmc Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production
    Danna M Breen
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Diabetes 60:3148-53. 2011
    ..We here evaluate whether activation of duodenal mucosal PKC-δ lies upstream (and/or downstream) of CCK signaling to lower glucose production...
  53. ncbi Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33
    Shannon A Metcalf
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Peptides 32:1296-302. 2011
    ..Reduction of cumulative food intake by CCK-8 in II rats was blocked by devazepide, a CCK(1) receptor antagonist...
  54. ncbi Effect of protein source in diets fed during gestation and lactation on food intake regulation in male offspring of Wistar rats
    Alireza Jahan-Mihan
    Dept of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 300:R1175-84. 2011
    ..4% higher, respectively, in offspring of dams fed the S diet. Altered FI regulation was shown by failure of devazepide (a CCK-A receptor blocker) to block FI reduction after protein preloads in offspring of S diet-fed dams, whereas ..
  55. ncbi Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis
    Tim Lubbers
    Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Crit Care Med 38:1996-2002. 2010
    ..The current study investigates whether nutritional stimulation of the autonomic nervous system effectively attenuates the inflammatory response in murine Gram-negative sepsis...
  56. ncbi Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line
    Karim El-Kouhen
    Faculty of Medicine, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Pancreas 39:127-34. 2010
    ..This study evaluated the role played by cholecystokinin (CCK) receptors' occupation in the control of somatostatin (SS) secretion in RIN-14B cells...
  57. ncbi Activation of cholecystokinin (CCK 1) and serotonin (5-HT 3) receptors increases the discharge of pancreatic vagal afferents
    Bashair M Mussa
    University of Melbourne, Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, Heidelberg 3084, Victoria, Australia
    Eur J Pharmacol 601:198-206. 2008
    ..Cholecystokinin CCK(1) receptor antagonists, lorglumide (10 mg/kg, i.v.) and devazepide (0.5 mg/kg, i.v...
  58. ncbi Disruption of seasonality in growth hormone-transgenic coho salmon (Oncorhynchus kisutch) and the role of cholecystokinin in seasonal feeding behavior
    Mare Lõhmus
    Fisheries and Oceans Canada, Centre for Aquaculture and Environmental Research, 4160 Marine Drive, West Vancouver, V7V 1N6, BC Canada
    Horm Behav 54:506-13. 2008
    ..GH-transgenic coho salmon; second, to determine the behavioural effect of blocking the action of CCK (by using devazepide) on the seasonal food intake; and third, to measure CCK expression in brain and gut tissues between the two ..
  59. ncbi Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat
    Shannon J Raboin
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, United States
    Regul Pept 150:73-80. 2008
    ..Camostat also increased Fos-LI in the DVC. Experiment 2: Pretreatment with devazepide, a specific CCK(1) receptor antagonist abolished camostat-induced Fos-LI in the submucosal plexus and the DVC...
  60. ncbi Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase
    Caroline Morel
    Laboratoire des Aminoacides, Peptides, et Protéines, CNRS Unite Mixte de Recherche 5810, UMI et UMII, UFR Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Biol Chem 280:21384-93. 2005
    ..They open the way to potential design of either a new family of MAP kinase inhibitors from CCK1 receptor ligand structures or new CCK1 receptor ligands based on p38 MAP kinase inhibitor structures...
  61. ncbi Exogeneous and endogenous CCK inhibit ethanol ingestion in Sardinian alcohol-preferring rats
    Nori Geary
    Department of Psychiatry, E W Bourne Behavioral Research Laboratory, New York Presbyterian Hospital, Weill Medical College of Cornell University, White Plains 10605, USA
    Peptides 25:1185-94. 2004
    ..intake despite simultaneously reducing blood ethanol levels (BALs); and (5) antagonism of CCK1 receptors with devazepide increased ethanol intake, indicating that endogenous CCK normally limits the size of bouts of ethanol ingestion...
  62. ncbi Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats
    Mieko Kurosawa
    Center for Medical Science, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Neurosci Lett 362:213-5. 2004
    ..These results suggest that nicotine can exert its anorexic effect via an increase in gastric vagal afferent activity which is caused by enhanced release of both cholecystokinin and prostaglandins...
  63. pmc Cholecystokinin blockade alters the systemic immune response in rats with acute pancreatitis
    Ana Maria de la Mano
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Int J Exp Pathol 85:75-84. 2004
    ..However, at the point of maximal injury, the inflammatory response became pronounced, largely due to the role played by activated T lymphocytes...
  64. ncbi Structure-activity function for binding and signaling in CHO-K1 and COS-7 cells expressing the cholecystokinin A receptor
    Yasuhiro Tsunoda
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 314:861-9. 2004
    ..Three-dimensional modeling showed that the CCK-A receptor (CCK-AR) antagonist devazepide penetrated into the transmembrane (TM) domains, whereas CCK was placed on the surface of the CCK-AR...
  65. ncbi Inhibitory effect of the lectin wheat germ agglutinin on the binding of 125I-CCK-8s to the CCK-A and -B receptors of AR42J cells
    Ingo Damm
    Department of Pathology, Faculty of Medicine, University of Rostock, Rostock, Germany
    Pancreas 28:31-7. 2004
    ..The pancreatic CCK receptors are highly glycosylated membrane proteins that are able to bind plant lectins such as wheat germ agglutinin (WGA) and Ulex europaeus agglutinin (UEA-I)...
  66. ncbi Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine
    Melina Ellis
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 304:G749-61. 2013
    ..antagonists granisetron (5-HT(3), 1 μM) and SB-207266 (5-HT(4), 10 nM) and the CCK receptor antagonists devazepide (CCK-1, 300 nM) and L-365260 (CCK-2, 300 nM), but these antagonists did not further depress segmentation when ..
  67. ncbi Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas
    I Rooman
    Cell Differentiation Unit, Diabetes Research Center, Free University Brussel, Brussels, Belgium
    Gastroenterology 121:940-9. 2001
    ..CONCLUSIONS: Duct-like pancreatic epithelial cells in vitro and ductal complexes in vivo express gastrin/CCK-B receptors and proliferate in response to gastrin...
  68. ncbi The effect of centrally administered CCK-receptor antagonists on food intake in rats
    E S Corp
    Department of Psychiatry, Cornell University Medical College, The New York Hospital Cornell Medical Center, White Plains 10605, USA
    Physiol Behav 61:823-7. 1997
    ..Two selective CCK(A)-receptor antagonists, lorglumide and devazepide, did not increase intake significantly when given alone, and they did not attenuate the effect of peripherally ..
  69. ncbi Central administration of Tyr-MIF-1 stimulates gastrointestinal motility in rats: evidence for the involvement of dopamine, sigma and CCK receptors
    M Million
    Department of Pharmacology, INRA BP3, Toulouse
    Neuropeptides 26:77-85. 1994
    ..Domperidone, (+)SCH 23390, devazepide, PK 11-195 and flumazenil did not have effect on the action of Tyr-MIF-1...
  70. ncbi Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice
    N Geary
    Bourne Behavioral Research Laboratory, Department of Psychiatry, New York Presbyterian Hospital Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Endocrinology 142:4751-7. 2001
    ..on feeding in rats, the influence of ip injections of 250 microg of the selective CCK(A) receptor antagonist devazepide was then tested...
  71. pmc The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist
    L Singh
    Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
    Br J Pharmacol 104:239-45. 1991
    ..In contrast, the selective CCKA receptor antagonist, devazepide, was inactive...
  72. ncbi Luminal dietary protein, not amino acids, induces pancreatic protease via CCK in pancreaticobiliary-diverted rats
    H Hara
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Am J Physiol Gastrointest Liver Physiol 278:G937-45. 2000
    ..These pancreatic changes by the diets were abolished by treatment with devazepide, a CCK-A receptor antagonist...
  73. ncbi Acute taurodeoxycholate-induced pancreatitis in the rat is associated with hyperCCKemia
    B Ohlsson
    Department of Surgery, University Hospital, Lund, Sweden
    Int J Pancreatol 27:195-201. 2000
    ..In the present study we measured plasma CCK concentrations in acute experimental pancreatitis (AEP) in the rat, and evaluated the role of circulating CCK levels on the initial pancreatic damage in pancreatitis...
  74. ncbi Involvement of CCK in the paraventricular nucleus of the hypothalamus in the CNS regulation of colonic motility
    H Monnikes
    Department of Internal Medicine, Philipps University of Marburg, Germany
    Digestion 62:178-84. 2000
    ..The data suggest, that endogenous CCK in the paraventricular nucleus of the hypothalamus unfolds a stimulatory effect on colonic transit through action on CCK-B receptors...
  75. pmc Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones
    M Beinborn
    Division of Gastroenterology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Yale J Biol Med 71:337-46. 1998
    ..These dual properties of synthetic molecules must be considered when evaluating candidate drugs for human disease...
  76. ncbi Role of cholecystokinin in the intestinal fat- and acid-induced inhibition of gastric secretion
    S J Konturek
    Institute of Physiology, Academy of Medicine, Krakow, Poland
    Regul Pept 42:97-109. 1992
    ..We conclude that CCK released by intestinal peptone meal, containing fat or acid, exerts a tonic inhibitory influence on gastric acid secretion and gastrin release through the CCK-A receptors...
  77. pmc Functional comparisons of gastrin/cholecystokinin receptors in isolated preparations of gastric mucosa and ileum
    M Patel
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 106:275-82. 1992
    ..plexus (GPI) have been characterized by use of peptide agonists and the non-peptide antagonists, lorglumide, devazepide and L-365,260. 2...
  78. ncbi Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    Pflugers Arch 445:187-93. 2002
    ..However, administration of atosiban alone had no effect on gastric emptying. Devazepide (3 mg x kg(-1)), a selective CCKA receptor antagonist, effectively attenuated the OT-induced inhibition of ..
  79. ncbi Endogenous CCK in the control of gastric emptying of glucose and maltose
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Peptides 18:547-50. 1997
    ..Intragastric administration of a dose range (10-100 micrograms/kg) of the CCKA receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but ..
  80. ncbi Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Surg Res 106:273-81. 2002
    ..Serotonin inhibits food intake, and postprandial serotonin release is increased after total gastrectomy. Serotonin might contribute to early satiety and loss of body weight after total gastrectomy...
  81. pmc Total gastrectomy severely alters the central regulation of food intake in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, Germany
    Ann Surg 236:166-76. 2002
    ..To investigate the central regulation of food intake by quantifying neuron activation of the nucleus of the solitary tract (NTS) after injection of cholecystokinin (CCK) or food intake in gastrectomized rats...
  82. ncbi Inhibition of gastric emptying by bombesin-like peptides is dependent upon cholecystokinin-A receptor activation
    E E Ladenheim
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Regul Pept 84:101-6. 1999
    ..peptides is mediated by a CCK-dependent mechanism, we examined the ability of the CCK-A receptor antagonist, devazepide, to block the inhibition of saline gastric emptying produced by BN, GRP18-27 and NMB...
  83. ncbi Biological effects of newly synthesized cholecystokinin analogs
    E J Verspohl
    Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Munster, Germany
    Horm Res 53:177-84. 2000
    ..The data indicate that some of the newly synthesized CCK tetrapeptides exhibit a high affinity for the CCK receptor of beta-cells and have an insulinotropic effect much higher than CCK(4)...
  84. ncbi CCK-8 activates hepatic vagal C-fiber afferents
    J E Cox
    Department of Psychology, University of Alabama at Birmingham 35294, USA
    Brain Res 776:189-94. 1997
    ..v. administration of 200 micrograms/kg of the CCKA receptor antagonist devazepide. Control comparisons indicated that this reduction was not an artifact of tachyphylaxis resulting from repeated ..
  85. pmc Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats
    Clemence Blouet
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 7:e51898. 2012
    ..Systemic administration of the CCKA receptor antagonist devazepide blocked the ability of duodenal lipids to increase brown fat thermogenesis...
  86. ncbi Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats
    Zhi Hong Yang
    Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 32 3 Nanakuni 1 Chome Hachioji, Tokyo 192 0991, Japan
    Appetite 65:1-7. 2013
    ..The suppression of food intake by palmitoleic acid was attenuated by intravenous injection of devazepide, a selective peripheral CCK receptor antagonist...
  87. ncbi Synthesis of new 1,3,4-benzotriazepin-5-one derivatives and their biological evaluation as antitumor agents
    Azza T Taher
    Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, P O Box 11562, Cairo, Egypt
    Arch Pharm Res 36:684-93. 2013
    ..of 1,3,4-benzotriazepin-5-one were designed and synthesized as structural analogues to the antitumor agents devazepide and asperlicin...
  88. ncbi Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety
    Heng Li
    Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8553, Japan
    Behav Brain Res 237:325-32. 2013
    ..The effects of CCK(A) and CCK(B) receptor antagonists (devazepide and CI-988, respectively) were examined using mouse anxiety tests (elevated-plus maze and light-dark box) and ..
  89. pmc Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, USA
    Assay Drug Dev Technol 9:394-402. 2011
    ..The biological, pharmacological, and fluorescence properties of this reagent are described, and proof-of-concept is provided in a fluorescence polarization assay utilizing this fluorescent benzodiazepine ligand...
  90. ncbi Effects of CCK-receptor antagonists on CCK-stimulated pepsinogen secretion and calcium increase in isolated guinea pig gastric chief cells
    C Sakamoto
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Dig Dis Sci 35:873-8. 1990
    ..These results suggest that L-364,718 and CR1409 act as CCK-receptor antagonists, but dbcGMP has another inhibitory effect on pepsinogen secretion in addition to the effect as a CCK-receptor antagonist in guinea pig gastric chief cells...
  91. ncbi Pituitary adenylate cyclase activating polypeptide stimulates gallbladder motility in conscious dogs
    A Mizumoto
    Second Department of Surgery, Shiga University of Medical Science, Japan
    Regul Pept 42:39-50. 1992
    ..It was concluded that PACAP27 and PACAP38 stimulate gallbladder motility in conscious dogs through a preganglionic cholinergic mechanism...
  92. pmc PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats
    I Verbaeys
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Campus Kortrijk, Kortrijk, Belgium
    Br J Pharmacol 155:417-23. 2008
    ..In this study, we investigated the ability of different doses of PEG-CCK9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction...
  93. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats
    Chiu Lung Wu
    Department of Basic Medical Science, Hung Kuang University, Taiwan, ROC
    Eur J Pharmacol 580:407-15. 2008
    ..The selective CCK1 receptor antagonists, devazepide and lorglumide, effectively attenuated the oxytocin-induced inhibition of gastric emptying and gastrointestinal ..
  94. ncbi Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007
    ..intragastric artery injection of urocortin 2 after CCK at a subthreshold dose, and the response was reversed by devazepide. These data establish a peripheral synergistic interaction between CCK and urocortin 1 or urocortin 2 to ..
  95. ncbi Peripherally administered calcitonin gene-related peptide decreases food intake in mice
    J E Morley
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Peptides 17:511-6. 1996
    ..The effect of CGRP on food intake was not antagonized by the cholecystokinin A receptor antagonist, L364,718. These studies suggest a role for CGRP as a satiating factor...
  96. ncbi Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells
    J M Dickenson
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, UK
    Eur J Pharmacol 302:141-51. 1996
    ....
  97. ncbi Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors
    David M Savastano
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, United States
    Physiol Behav 92:434-42. 2007
    ..Combined administration of 1 mg/kg ondansetron (Ond) and 1 mg/kg devazepide (Dev) reversed 132 mM Polycose-induced suppression to the level of control intake and significantly attenuated ..
  98. ncbi The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats
    K H Kim
    Department of Pharmacology, Yonsei University, College of Medicine, Seoul, Korea
    Int J Pancreatol 20:205-11. 1996
    ....
  99. ncbi CCK is involved in both peripheral and central mechanisms controlling food intake in chickens
    A Rodriguez-Sinovas
    Department of Cell Biology and Physiology, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain
    Am J Physiol 272:R334-40. 1997
    ..Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed...
  100. ncbi Effects of atropine on pancreatic response to bethanechol, cholecystokinin, and food intake in rats
    M F O'rourke
    Department of Physiology, University of Missouri Medical School, Columbia 65211
    Am J Physiol 261:G735-41. 1991
    ....
  101. ncbi The seventh transmembrane domain of gastrin/CCK receptors contributes to non-peptide antagonist binding
    T Mantamadiotis
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Biochem Biophys Res Commun 201:1382-9. 1994
    ..Furthermore, the affinity of the chimaera for gastrin is essentially the same as the gastrin/CCK-B receptor, indicating that the six different amino acids probably do not contribute to peptide agonist binding...

Research Grants7

  1. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 2001
    ..Recent studies demonstrating that devazepide, a CCK-A receptor antagonist that penetrates the blood/brain barrier, stimulates feeding in a variety of species ..
  2. MECHANISMS UNDERLYING MATERNAL CALMING AND ANALGESIA
    ELLIOTT BLASS; Fiscal Year: 1993
    ..They will also reveal potential lasting effects of these influences beyond their proximal effects. They will provide a basis for evaluating normal development and that of infants from abnormal populations (drug addiction, for example)...
  3. IL-lB and Meal Patterns: Ovarian Hormones and CCK
    PETER BUTERA; Fiscal Year: 2002
    ....
  4. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..
  5. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..