devazepide

Summary

Summary: A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.

Top Publications

  1. ncbi Different role of cholecystokinin (CCK)-A and CCK-B receptors in relapse to morphine dependence in rats
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 200032, Shanghai, People s Republic of China
    Behav Brain Res 120:105-10. 2001
  2. ncbi Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R389-98. 2003
  3. ncbi Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats
    Lin Lu
    Kailuan Mental Health Center, Tangshan 063001, China
    Brain Res 954:132-40. 2002
  4. doi Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth
    Jaime Carrillo
    Laboratorio de Genética y Patología Molecular de Tumores Sólidos Infantiles, Departamento de Biología Molecular y Celular del Cáncer, Instituto de Investigaciones Biomédicas A Sols CSIC UAM, Madrid 28029, Spain
    Anticancer Drugs 20:527-33. 2009
  5. ncbi Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
    R A Cowles
    Department of Surgery, University of Michigan, 2920B Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0331, USA
    Regul Pept 99:61-8. 2001
  6. ncbi Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway
    J Glatzle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Physiol Regul Integr Comp Physiol 287:R354-9. 2004
  7. ncbi Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents
    Robert C Ritter
    Am J Physiol Regul Integr Comp Physiol 286:R991-3. 2004
  8. pmc Cholecystokinin blockade alters the systemic immune response in rats with acute pancreatitis
    Ana Maria de la Mano
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Int J Exp Pathol 85:75-84. 2004
  9. ncbi Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats
    Mieko Kurosawa
    Center for Medical Science, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Neurosci Lett 362:213-5. 2004
  10. ncbi Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice
    Michael M Chi
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1044-53. 2004

Detail Information

Publications126 found, 100 shown here

  1. ncbi Different role of cholecystokinin (CCK)-A and CCK-B receptors in relapse to morphine dependence in rats
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 200032, Shanghai, People s Republic of China
    Behav Brain Res 120:105-10. 2001
    ..These findings suggest that CCK-B receptor antagonists might be of some value in the treatment and prevention of relapse to drug dependence long after detoxification...
  2. ncbi Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R389-98. 2003
    ..Fasted rats with open gastric fistulas received devazepide (1 mg/kg iv) or A-70104 (700 nmol. kg(-1). h(-1) iv) and either a 30-min intravenous infusion of CCK-8 (10 nmol...
  3. ncbi Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats
    Lin Lu
    Kailuan Mental Health Center, Tangshan 063001, China
    Brain Res 954:132-40. 2002
    The effects of different cholecystokinin (CCK) receptor antagonists (devazepide and L365,260) on cocaine or stress-induced reactivation of cocaine conditioned place preference (CPP) were investigated in rats...
  4. doi Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth
    Jaime Carrillo
    Laboratorio de Genética y Patología Molecular de Tumores Sólidos Infantiles, Departamento de Biología Molecular y Celular del Cáncer, Instituto de Investigaciones Biomédicas A Sols CSIC UAM, Madrid 28029, Spain
    Anticancer Drugs 20:527-33. 2009
    ..Here, we analyzed the impact of two CCK receptor antagonists, devazepide (a CCK1-R antagonist) and L365 260 (a CCK2-R antagonist), on the growth of Ewing tumor cells...
  5. ncbi Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
    R A Cowles
    Department of Surgery, University of Michigan, 2920B Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0331, USA
    Regul Pept 99:61-8. 2001
    ..CART peptide likely acts upon either peripheral or central regulators of pancreatic secretory function that are distant from the acinar unit...
  6. ncbi Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway
    J Glatzle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Physiol Regul Integr Comp Physiol 287:R354-9. 2004
    ..was significantly reduced by 77 and 55%, respectively, in rats treated with the CCK(1) receptor blocker devazepide or after functional vagal deafferentation by perineural capsaicin treatment...
  7. ncbi Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents
    Robert C Ritter
    Am J Physiol Regul Integr Comp Physiol 286:R991-3. 2004
  8. pmc Cholecystokinin blockade alters the systemic immune response in rats with acute pancreatitis
    Ana Maria de la Mano
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Int J Exp Pathol 85:75-84. 2004
    ..However, at the point of maximal injury, the inflammatory response became pronounced, largely due to the role played by activated T lymphocytes...
  9. ncbi Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats
    Mieko Kurosawa
    Center for Medical Science, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Neurosci Lett 362:213-5. 2004
    ..These results suggest that nicotine can exert its anorexic effect via an increase in gastric vagal afferent activity which is caused by enhanced release of both cholecystokinin and prostaglandins...
  10. ncbi Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice
    Michael M Chi
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1044-53. 2004
    ..Moreover, devazepide prevented this suppression, indicating this increased sensitivity was mediated by CCK-1 receptors...
  11. ncbi Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase
    Caroline Morel
    Laboratoire des Aminoacides, Peptides, et Protéines, CNRS Unite Mixte de Recherche 5810, UMI et UMII, UFR Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Biol Chem 280:21384-93. 2005
    ..They open the way to potential design of either a new family of MAP kinase inhibitors from CCK1 receptor ligand structures or new CCK1 receptor ligands based on p38 MAP kinase inhibitor structures...
  12. ncbi L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats
    A Shemyakin
    Department of Biological Sciences, Fordham University, Bronx, New York 10458, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1420-6. 2001
    ..These results suggest that endogenous CCK, acting on CCK-A receptors, may play a key role in eliciting postprandial sleep...
  13. ncbi Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats
    Jelena Pupovac
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2
    J Nutr 132:2775-80. 2002
    ..The CCK-A receptor antagonist, devazepide (which reverses protein-induced food intake suppression), when given at 0.25 mg/kg, i.p...
  14. ncbi Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Surg Res 106:273-81. 2002
    ..Serotonin inhibits food intake, and postprandial serotonin release is increased after total gastrectomy. Serotonin might contribute to early satiety and loss of body weight after total gastrectomy...
  15. ncbi Intermolecular interactions between peptidic and nonpeptidic agonists and the third extracellular loop of the cholecystokinin 1 receptor
    Craig Giragossian
    Department of Chemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Med Chem 46:3476-82. 2003
    ..The proposed binding modes of GI5269 and GI0122 are supported by the structure-activity relationship of analogues and mutagenesis data for the CCK(1)-R selective antagonist L-364,718...
  16. ncbi Vagal afferent responses to fatty acids of different chain length in the rat
    S Lal
    Department of Gastro-Intestinal Sciences, Hope Hospital, Salford M6 8HD, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 281:G907-15. 2001
    ..The effect of oleate was abolished by the CCK-A receptor antagonist Devazepide (0...
  17. ncbi Cholecystokinin reduces ethanol consumption in golden hamsters
    David Dibattista
    Brock University, Department of Psychology, St Catharines, Ontario, Canada L2S 3A1
    Alcohol 29:173-81. 2003
    ..Findings are consistent with the notion that endogenous CCK plays a key role in the short-term control of ethanol intake in hamsters...
  18. ncbi Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors
    J Glatzle
    University Hospital, Department of General and Transplantation Surgery, , , Germany
    Am J Physiol Regul Integr Comp Physiol 281:R222-9. 2001
    ..Taken together with the results of the food intake studies, this suggests that activation of CCK-A receptors is involved in the postprandial activation of NTS neurons and in the regulation of food intake...
  19. ncbi Molecular cloning of an unusual bicistronic cholecystokinin receptor mRNA expressed in chicken brain: a structural and functional expression study
    Isabelle B M Nilsson
    Strategic Development LMO, Molecular Biology Laboratory, University Hospital, Linköping S 581 85, Sweden
    Regul Pept 114:37-43. 2003
    ..agonists (CCK-8, CCK-4, gastrin-17), whereas CCK-CHR showed higher affinity for the CCK-A receptor antagonist, devazepide, than for the CCK-B receptor antagonist, L-365,260...
  20. ncbi Abdominal vagal mediation of the satiety effects of CCK in rats
    Roger D Reidelberger
    Department of Veterans Affairs Nebraska Western Iowa Health Care System, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1005-12. 2004
    ..b>Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt of N alpha-3-quinolinoyl-D-Glu-N,N-..
  21. ncbi Inhibitory effect of the lectin wheat germ agglutinin on the binding of 125I-CCK-8s to the CCK-A and -B receptors of AR42J cells
    Ingo Damm
    Department of Pathology, Faculty of Medicine, University of Rostock, Rostock, Germany
    Pancreas 28:31-7. 2004
    ..The pancreatic CCK receptors are highly glycosylated membrane proteins that are able to bind plant lectins such as wheat germ agglutinin (WGA) and Ulex europaeus agglutinin (UEA-I)...
  22. ncbi Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas
    I Rooman
    Cell Differentiation Unit, Diabetes Research Center, Free University Brussel, Brussels, Belgium
    Gastroenterology 121:940-9. 2001
    ..CONCLUSIONS: Duct-like pancreatic epithelial cells in vitro and ductal complexes in vivo express gastrin/CCK-B receptors and proliferate in response to gastrin...
  23. ncbi Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat
    Shannon J Raboin
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, United States
    Regul Pept 150:73-80. 2008
    ..Camostat also increased Fos-LI in the DVC. Experiment 2: Pretreatment with devazepide, a specific CCK(1) receptor antagonist abolished camostat-induced Fos-LI in the submucosal plexus and the DVC...
  24. ncbi Effects of peripheral CCK receptor blockade on gastric emptying in rats
    Roger D Reidelberger
    Veterans Affairs Medical Center, Omaha 68105, USA
    Am J Physiol Regul Integr Comp Physiol 284:R66-75. 2003
    Type A CCK receptor (CCKAR) antagonists differing in blood-brain barrier permeability [devazepide penetrates; the dicyclohexylammonium salt of Nalpha-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-70104) does not] were used to test the ..
  25. ncbi Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats
    Jerome Gay
    Neuro Gastroenterology and Nutrition Unit, Institut National de la Recherche, Agronomique, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex, France
    Brain Behav Immun 17:35-42. 2003
    ..Thus, in our experimental conditions, i.e., within 30-50 days post-N. brasiliensis infection, we observed an enhancement of the anorectic effect of exogenous CCK involving mast cell degranulation and histamine...
  26. ncbi [The effects of cholecystokinin octapeptide on PKC activity in rat cerebral cortex neurocytes]
    Peng Xiang
    Lab of Hormone receptor, Department of Biochemistry, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 33:72-4, 120. 2002
    ..To investigate the effects of CCK8 on protein kinase C activity in rat cerebral cortex...
  27. ncbi Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Shih Pai, Taipei 11221, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 367:406-13. 2003
    ..The selective CCK(1) receptor antagonists, devazepide and lorglumide, effectively attenuated the OT-induced inhibition of gastric emptying and gastrointestinal ..
  28. ncbi Soybean beta-conglycinin peptone suppresses food intake and gastric emptying by increasing plasma cholecystokinin levels in rats
    Takashi Nishi
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 133:352-7. 2003
    ..The suppression of food intake by beta-conglycinin peptone was abolished by an intravenous injection of devazepide, a selective peripheral CCK receptor antagonist...
  29. pmc Total gastrectomy severely alters the central regulation of food intake in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, Germany
    Ann Surg 236:166-76. 2002
    ..To investigate the central regulation of food intake by quantifying neuron activation of the nucleus of the solitary tract (NTS) after injection of cholecystokinin (CCK) or food intake in gastrectomized rats...
  30. ncbi Effects of peripheral CCK receptor blockade on food intake in rats
    Roger D Reidelberger
    Department of Veterans Affairs, Nebraska Western Iowa Health Care System, Omaha 68105, USA
    Am J Physiol Regul Integr Comp Physiol 285:R429-37. 2003
    ..At dark onset, non-food-deprived rats received a bolus injection of devazepide (2...
  31. ncbi Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    Pflugers Arch 445:187-93. 2002
    ..However, administration of atosiban alone had no effect on gastric emptying. Devazepide (3 mg x kg(-1)), a selective CCKA receptor antagonist, effectively attenuated the OT-induced inhibition of ..
  32. pmc Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat
    A J Gaw
    Peptic Ulceration Group, Pharmacology I, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 115:660-4. 1995
    ..the pressor response and bradycardia elicited by sCCK-8 were reduced by the selective CCKA receptor antagonists, devazepide (0.5-50 nmol kg-1) and lorglumide (1-7 mumol kg-1)...
  33. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats
    C L Wu
    Dept of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Scand J Gastroenterol 37:1133-9. 2002
    ..The effects of estradiol benzoate (EB) on gastric emptying, gastrointestinal transit and plasma levels of cholecystokinin (CCK) were studied in ovariectomized rats...
  34. pmc PEGylated cholecystokinin prolongs satiation in rats: dose dependency and receptor involvement
    I Verbaeys
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium
    Br J Pharmacol 152:396-403. 2007
    ..The present study assessed the dose-dependency of this response and the effect of two selective CCK(1) receptor antagonists, with different abilities to cross the blood-brain barrier (BBB), on PEG-CCK(9)-induced anorexia...
  35. ncbi Role of cholecystokinin in the gastric motor response to a meal in horses
    Mireia Lorenzo-Figueras
    Island Whirl Equine Colic Research Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Am J Vet Res 67:1998-2005. 2006
    ....
  36. ncbi Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isogami dori, Chuo Ku, Kobe, 651 0084, Japan
    Regul Pept 141:8-11. 2007
    ..These results indicated that elevated CCK may contribute to anorexic and anxious phenotype of PP overexpressing mice...
  37. ncbi Mediators of glucagon-like peptide 2-induced blood flow: responses in different vascular sites
    Mustafa Deniz
    Marmara University School of Medicine, Department of Physiology, 34668 Haydarpasa, Istanbul, Turkey
    Regul Pept 142:7-15. 2007
    ..Our results also suggest that the stimulatory effect of GLP-2 on SMA blood flow is NO-dependent and mediated via intrinsic, non-cholinergic enteric neurons...
  38. ncbi Distinct receptors for cholecystokinin and gastrin on canine fundic D-cells
    J Delvalle
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109
    Am J Physiol 264:G811-5. 1993
    ..These studies delineate the presence of distinct CCK-A and CCK-B/gastrin receptors on canine fundic D-cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  39. ncbi The soybean beta-conglycinin beta 51-63 fragment suppresses appetite by stimulating cholecystokinin release in rats
    Takashi Nishi
    Northern Advancement Center for Science and Technology, Colabo Hokkaido, Sapporo 001 0021, Japan
    J Nutr 133:2537-42. 2003
    ..These results indicate that the beta-conglycinin beta 51-63 fragment is the bioactive appetite suppressant in beta-conglycinin, and multiple arginine residues in the fragment may be involved in this effect...
  40. ncbi Intestinal transit of fat depends on accelerating effect of cholecystokinin and slowing effect of an opioid pathway
    Henry C Lin
    Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    Dig Dis Sci 47:2217-21. 2002
    ..1 mg/kg devazepide (a peripheral CCK-A-receptor antagonist) administered intraluminally and intravenously, respectively...
  41. pmc Functional comparisons of gastrin/cholecystokinin receptors in isolated preparations of gastric mucosa and ileum
    M Patel
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 106:275-82. 1992
    ..plexus (GPI) have been characterized by use of peptide agonists and the non-peptide antagonists, lorglumide, devazepide and L-365,260. 2...
  42. ncbi Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum
    M Storr
    Department of Internal Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Neuropharmacology 44:524-32. 2003
    ..1%), devazepide (10(-8) M: +19.4%; 10(-7) M: +30.0%) and SR-27897 (10(-10) M: +21.8%, 10(-8) M: +47.0%, P<0.05, n=8)...
  43. pmc Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin
    M Blackmore
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 66:32-8. 1992
    ..6 x 10(-5) M) and the CCK-A receptor antagonist devazepide (1...
  44. ncbi Cholecystokinin-8S-induced intracellular calcium signaling in acutely isolated periaqueductal gray neurons of the rat
    Yu Mi Yang
    Biomedical Research Center, Korea Institute of Science and Technology KIST, Seoul, Korea
    Biol Pharm Bull 30:297-302. 2007
    ..The evidence presented here expands our understanding of cellular mechanisms for CCK-mediated anti-analgesic and anxiogenic actions in the PAG...
  45. ncbi Central administration of Tyr-MIF-1 stimulates gastrointestinal motility in rats: evidence for the involvement of dopamine, sigma and CCK receptors
    M Million
    Department of Pharmacology, INRA BP3, Toulouse
    Neuropeptides 26:77-85. 1994
    ..Domperidone, (+)SCH 23390, devazepide, PK 11-195 and flumazenil did not have effect on the action of Tyr-MIF-1...
  46. ncbi Inhibition of gastric emptying by bombesin-like peptides is dependent upon cholecystokinin-A receptor activation
    E E Ladenheim
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Regul Pept 84:101-6. 1999
    ..peptides is mediated by a CCK-dependent mechanism, we examined the ability of the CCK-A receptor antagonist, devazepide, to block the inhibition of saline gastric emptying produced by BN, GRP18-27 and NMB...
  47. ncbi Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene
    J Dunlop
    Biochemistry Laboratory, Wyeth Research UK Ltd, Taplow, Maidenhead
    Neuropeptides 30:359-63. 1996
    ..CCK-8S > CI988 > PD 135158 > pentagastrin > CCK-8NS > L-365,260 > CCK-4 > LY 288513 > devazepide > A71378 > lorglumide) was found to be in excellent agreement with CCK-B receptor pharmacology described ..
  48. pmc Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations
    S Koks
    Department of Physiology, University of Tartu, Estonia, Männistö
    J Psychiatry Neurosci 25:33-42. 2000
    ..Differences in the anxiety levels of rats in summer and winter, and the role of CCK in these behavioural alterations, were also examined...
  49. ncbi Activation of cholecystokinin (CCK 1) and serotonin (5-HT 3) receptors increases the discharge of pancreatic vagal afferents
    Bashair M Mussa
    University of Melbourne, Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, Heidelberg 3084, Victoria, Australia
    Eur J Pharmacol 601:198-206. 2008
    ..Cholecystokinin CCK(1) receptor antagonists, lorglumide (10 mg/kg, i.v.) and devazepide (0.5 mg/kg, i.v...
  50. ncbi Acute taurodeoxycholate-induced pancreatitis in the rat is associated with hyperCCKemia
    B Ohlsson
    Department of Surgery, University Hospital, Lund, Sweden
    Int J Pancreatol 27:195-201. 2000
    ..In the present study we measured plasma CCK concentrations in acute experimental pancreatitis (AEP) in the rat, and evaluated the role of circulating CCK levels on the initial pancreatic damage in pancreatitis...
  51. ncbi Endogenous oxytocin excites phasic contraction of gallbladder in rabbits through oxytocin receptor
    Chuan Yong Liu
    Institute of Physiology, Medical School of Shandong University, Jinan, Shandong, PR China
    Chin J Physiol 46:95-101. 2003
    ..We suggest that endogenous OT regulates gallbladder phasic contraction through specific OT receptor. This effect is independent of the peripheral CCK and M receptors...
  52. ncbi A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus
    M Corsi
    Glaxo Research Laboratories, Verona, Italy
    J Pharmacol Exp Ther 270:734-40. 1994
    ..The selective CCK-A antagonist L-364,718 (Devazepide) antagonized both types of contraction with a pKB of 10.10 and 9.95, respectively...
  53. pmc The effect of CCKB/gastrin antagonists on stimulated gastric acid secretion in the anaesthetized rat
    N J Hayward
    Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
    Br J Pharmacol 104:973-7. 1991
    ..5. The selective CCKA antagonist, devazepide, was inactive at up to 300 mumol kg-1 i.p. against the three stimulants of acid secretion. 6...
  54. ncbi Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rat
    Cherese N Sullivan
    Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1071-80. 2007
    ..Similar to CCK-8, devazepide, a specific CCK(1) receptor antagonist, and not L365,260, a specific CCK(2) receptor antagonist, attenuated the ..
  55. ncbi An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats
    Daniela M Sartor
    Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Regul Integr Comp Physiol 290:R625-33. 2006
    ..Alternatively, animals were pretreated with the CCK1 receptor antagonists devazepide and lorglumide or the 5-HT3 antagonist MDL-72222 before SO-SBTI administration...
  56. ncbi Secretion of pancreatic digestive enzymes induced in rats by first-time oral exposure to kidney bean E2L2 lectin is mediated only in part by cholecystokinin (CCK)
    G Grant
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Pancreas 19:382-9. 1999
    ..Additional mechanisms or hormones, such as secretin, may play a role in modulating later exocrine pancreas responses to PHA...
  57. ncbi Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback
    K L Whited
    Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA 95616, USA
    Endocrinology 148:4695-703. 2007
    ..inhibited gastric emptying of a chow meal in wild-type but not A-IV(-/-) mice andCCK(1)R receptor blockade with devazepide (10 microg/100 g), abolished PYY(3-36)-induced inhibition of gastric emptying...
  58. ncbi Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice
    N Geary
    Bourne Behavioral Research Laboratory, Department of Psychiatry, New York Presbyterian Hospital Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Endocrinology 142:4751-7. 2001
    ..on feeding in rats, the influence of ip injections of 250 microg of the selective CCK(A) receptor antagonist devazepide was then tested...
  59. pmc Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs
    Jie Zhu
    Department of Gastroenterology, Renmin Hospital and Research Center of Structural Biology, Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 16:1076-85. 2010
    ..To investigate the effects of sulfated cholecystokinin octapeptide (CCK-8S) on the contractile activity of guinea-pig proximal colon...
  60. doi Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin
    G Flemstrom
    Department of Neuroscience, Uppsala University, Sweden
    Acta Physiol (Oxf) 201:141-50. 2011
    ..We have investigated the effects of apelin peptides on duodenal bicarbonate secretion in vivo and the release of cholecystokinin (CCK) from acutely isolated mucosal cells and the neuroendocrine cell line STC-1...
  61. pmc Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats
    Clemence Blouet
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 7:e51898. 2012
    ..Systemic administration of the CCKA receptor antagonist devazepide blocked the ability of duodenal lipids to increase brown fat thermogenesis...
  62. doi Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats
    Zhi Hong Yang
    Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 32 3 Nanakuni 1 Chome Hachioji, Tokyo 192 0991, Japan
    Appetite 65:1-7. 2013
    ..The suppression of food intake by palmitoleic acid was attenuated by intravenous injection of devazepide, a selective peripheral CCK receptor antagonist...
  63. doi Synthesis of new 1,3,4-benzotriazepin-5-one derivatives and their biological evaluation as antitumor agents
    Azza T Taher
    Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, P O Box 11562, Cairo, Egypt
    Arch Pharm Res 36:684-93. 2013
    ..of 1,3,4-benzotriazepin-5-one were designed and synthesized as structural analogues to the antitumor agents devazepide and asperlicin...
  64. doi Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety
    Heng Li
    Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8553, Japan
    Behav Brain Res 237:325-32. 2013
    ..The effects of CCK(A) and CCK(B) receptor antagonists (devazepide and CI-988, respectively) were examined using mouse anxiety tests (elevated-plus maze and light-dark box) and ..
  65. pmc Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, USA
    Assay Drug Dev Technol 9:394-402. 2011
    ..The biological, pharmacological, and fluorescence properties of this reagent are described, and proof-of-concept is provided in a fluorescence polarization assay utilizing this fluorescent benzodiazepine ligand...
  66. ncbi Cholecystokinin antagonists may have detrimental effects on acute pancreatitis
    Isabel De Dios
    Dig Dis Sci 51:427-8. 2006
  67. ncbi Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007
    ..intragastric artery injection of urocortin 2 after CCK at a subthreshold dose, and the response was reversed by devazepide. These data establish a peripheral synergistic interaction between CCK and urocortin 1 or urocortin 2 to ..
  68. ncbi The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze
    M J Bickerdike
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, UK
    Eur J Pharmacol 271:403-11. 1994
    ..b>Devazepide, a selective CCKA receptor antagonist, L-365,260 (3R(+)-N-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-..
  69. ncbi Endogenous cholecystokinin is not a major regulator of food intake in the chicken
    Y H Choi
    Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan
    J Comp Physiol B 164:425-9. 1994
    ..The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken ..
  70. ncbi Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors
    David M Savastano
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, United States
    Physiol Behav 92:434-42. 2007
    ..Combined administration of 1 mg/kg ondansetron (Ond) and 1 mg/kg devazepide (Dev) reversed 132 mM Polycose-induced suppression to the level of control intake and significantly attenuated ..
  71. ncbi Peripherally administered calcitonin gene-related peptide decreases food intake in mice
    J E Morley
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Peptides 17:511-6. 1996
    ..The effect of CGRP on food intake was not antagonized by the cholecystokinin A receptor antagonist, L364,718. These studies suggest a role for CGRP as a satiating factor...
  72. ncbi Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells
    J M Dickenson
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, UK
    Eur J Pharmacol 302:141-51. 1996
    ....
  73. ncbi The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats
    K H Kim
    Department of Pharmacology, Yonsei University, College of Medicine, Seoul, Korea
    Int J Pancreatol 20:205-11. 1996
    ....
  74. ncbi CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Eur J Pharmacol 557:212-20. 2007
    ..to colonic preparations induced concentration-dependent contractions which were prevented by devazepide (CCK1 receptor antagonist), enhanced by GV150013 (CCK2 receptor antagonist) or N(omega)-nitro-L-arginine ..
  75. ncbi CCK is involved in both peripheral and central mechanisms controlling food intake in chickens
    A Rodriguez-Sinovas
    Department of Cell Biology and Physiology, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain
    Am J Physiol 272:R334-40. 1997
    ..Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed...
  76. ncbi The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat
    V Matto
    Department of Pharmacology, University of Tartu, Estonia
    Neuropharmacology 36:389-96. 1997
    ..study was to investigate the effects of cholecystokinin (CCK) CCK(A) and CCKB receptor antagonists SR 27897 B, devazepide, L 365260 and PD 135158 (CAM 1028) on exploratory behaviour in the elevated zero-maze in the rat...
  77. ncbi Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice
    Kristiina Roots
    Department of Biochemistry, Tartu University, Ravila 19, 50411 Tartu, Estonia
    Int J Dev Neurosci 24:395-400. 2006
    ..CCK1 receptor antagonist devazepide counteracted effect of CCK-8 in all three genotypes, whereas CCK2 receptor antagonist L-365, 260 showed ..
  78. ncbi The ontogeny of postingestive inhibitory stimuli: examining the role of CCK
    Aron Weller
    Department of Psychology, and the Gonda Goldschmied Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Dev Psychobiol 48:368-79. 2006
    ..The selective CCK(1) receptor antagonist devazepide was used to assess CCK mediation of the control of intake produced by particular sensory aspects of food, at the ..
  79. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats
    Chiu Lung Wu
    Department of Basic Medical Science, Hung Kuang University, Taiwan, ROC
    Eur J Pharmacol 580:407-15. 2008
    ..The selective CCK1 receptor antagonists, devazepide and lorglumide, effectively attenuated the oxytocin-induced inhibition of gastric emptying and gastrointestinal ..
  80. pmc PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats
    I Verbaeys
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Campus Kortrijk, Kortrijk, Belgium
    Br J Pharmacol 155:417-23. 2008
    ..In this study, we investigated the ability of different doses of PEG-CCK9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction...
  81. ncbi The seventh transmembrane domain of gastrin/CCK receptors contributes to non-peptide antagonist binding
    T Mantamadiotis
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Biochem Biophys Res Commun 201:1382-9. 1994
    ..Furthermore, the affinity of the chimaera for gastrin is essentially the same as the gastrin/CCK-B receptor, indicating that the six different amino acids probably do not contribute to peptide agonist binding...
  82. ncbi Pituitary adenylate cyclase activating polypeptide stimulates gallbladder motility in conscious dogs
    A Mizumoto
    Second Department of Surgery, Shiga University of Medical Science, Japan
    Regul Pept 42:39-50. 1992
    ..It was concluded that PACAP27 and PACAP38 stimulate gallbladder motility in conscious dogs through a preganglionic cholinergic mechanism...
  83. ncbi Effects of atropine on pancreatic response to bethanechol, cholecystokinin, and food intake in rats
    M F O'rourke
    Department of Physiology, University of Missouri Medical School, Columbia 65211
    Am J Physiol 261:G735-41. 1991
    ....
  84. doi Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia
    Rodrigo Rorato
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Exp Physiol 96:439-50. 2011
    ..Male Wistar rats were pretreated with a specific CCK(1) receptor antagonist (devazepide; 1 mg kg(-1); i.p.) or vehicle; 30 min later they received LPS (100 μg kg(-1); i.p.) or saline injection...
  85. doi L-364,718 potentiates electroacupuncture analgesia through cck-a receptor of pain-related neurons in the nucleus parafascicularis
    T F Shi
    Department of Surgery of Second Affiliated Hospital, Harbin Medical University, 150081 Harbin, Heilongjiang, People s Republic of China
    Neurochem Res 36:129-38. 2011
    ..Our results suggest that the pain-related neurons in the nPf have an important role in mediating EA analgesia. L-364,718 potentiates EA analgesia through the CCK-A receptor of PENs and PINs in the nPf...
  86. ncbi Role of cholecystokinin in postprandial and vagally stimulated duodenal and gallbladder motility in dogs
    P Thor
    Institute of Physiology, University Medical School, Krakow, Poland
    J Physiol Pharmacol 42:381-8. 1991
    ..We conclude that CCK contributes to the MMC related alterations in the GB motor activity and is essential in cholinergic stimulation induced of the GB emptying but not in vagally induced duodenal and GB motility...
  87. ncbi Cholecystokinin-induced contraction of opossum sphincter of Oddi. Mechanism of action
    N Hanyu
    Department of Radiology, Medical College of Wisconsin, Milwaukee 53226
    Dig Dis Sci 35:567-76. 1990
    ..abstract truncated at 250 words)..
  88. ncbi Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain
    Koji Yoshinaga
    Central Research Laboratories, Zeria Pharmaceutical Co, Ltd, 2512 1 Numagami, Oshikiri, Kumagaya, Saitama 360 0111, Japan
    Biol Pharm Bull 33:244-8. 2010
    ..In contrast, the CCK(1) receptor antagonist devazepide inhibited the nociceptive responses to formalin...
  89. ncbi Intestinal cholecystokinin controls glucose production through a neuronal network
    Grace W C Cheung
    Toronto General Research Institute, University Health Network, Toronto, Canada
    Cell Metab 10:99-109. 2009
    ..These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding...
  90. ncbi Effects of CCK-receptor antagonists on CCK-stimulated pepsinogen secretion and calcium increase in isolated guinea pig gastric chief cells
    C Sakamoto
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Dig Dis Sci 35:873-8. 1990
    ..These results suggest that L-364,718 and CR1409 act as CCK-receptor antagonists, but dbcGMP has another inhibitory effect on pepsinogen secretion in addition to the effect as a CCK-receptor antagonist in guinea pig gastric chief cells...
  91. ncbi Feline cholescintigraphy. Studies on role of cholecystokinin in regulation of gallbladder function
    T Niewiarowski
    Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania
    Dig Dis Sci 35:1098-104. 1990
    ..While CCK appears to be the primary modulator of gallbladder contraction after a fatty meal, no influence of CCK was detected in the interdigestive (fasting) state...
  92. pmc Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice
    Lenka Maletinska
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nAm, 2, 16610 Prague 6, Czech Republic
    BMC Neurosci 9:101. 2008
    ....
  93. pmc Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor
    Fan Gao
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Bioorg Med Chem Lett 18:4401-4. 2008
    ..Here, we used a specific assay of allosteric ligand interaction to probe the mode of binding of devazepide, a prototypic benzodiazepine ligand...
  94. ncbi Cholecystokinin regulates glycoprotein membrane composition of rat pancreatic zymogen granules
    I De Dios
    Department of Physiology and Pharmacology, Campus Miguel de Unamuno, University of Salamanca, Spain
    Biochim Biophys Acta 1326:131-7. 1997
    ..Our results suggest that glycoconjugates of zymogen granule membrane involved in CCK-regulated exocytosis contain N-acetylglucosamine and sialic acid residues whose quantities are regulated by CCK...
  95. ncbi Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice
    R M Bluthe
    INRA INSERM U 394, Domaine de Carreire, Bordeaux, France
    Physiol Behav 62:385-9. 1997
    ....
  96. pmc Apolipoprotein A-IV is involved in detection of lipid in the rat intestine
    K L Whited
    1321 Haring Hall, Vet Med APC, UC Davis School of Veterinary Medicine, Davis, CA 95616, USA
    J Physiol 569:949-58. 2005
    ..We conclude that activation of the vagal afferent pathway and inhibition of gastric function in response to dietary lipid is partly dependent upon apo A-IV...
  97. ncbi Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis
    Ana M de la Mano
    Department of Physiology and Pharmacology, University of Salamanca, 37008 Salamanca, Spain
    Peptides 24:535-41. 2003
    ..Our results indicate that the renewal of acinar cells deleted by apoptosis 48h after BPDO worsens if CCK is blocked before inducing AP...
  98. ncbi Cholecystokinin-A receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested
    Nick Bellissimo
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2
    J Nutr 133:2319-25. 2003
    ..b>Devazepide (0...
  99. ncbi c-Kit mutant mouse behavioral phenotype: altered meal patterns and CCK sensitivity but normal daily food intake and body weight
    Michael M Chi
    Dept of Psychological Sciences, Purdue Univ, 703 Third St, West Lafayette, IN 47907 2004, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1170-83. 2003
    ..satiety activated by CCK-A receptors, whereas the specificity of the response was assessed with the antagonist devazepide (300 microg/kg ip)...
  100. ncbi Cholecystokinin selectively affects presympathetic vasomotor neurons and sympathetic vasomotor outflow
    Daniela M Sartor
    Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria 3084, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R1174-84. 2002
    ..Vagotomy abolished the effects of CCK on MAP and SSND as did the CCK-A receptor antagonist devazepide (0.5 mg/kg iv). The bradycardic effect of CCK was unaltered by vagotomy but abolished by devazepide...
  101. pmc Roles for CCK1 and 5-HT3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat
    Mitsuhiko Saita
    Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria 3084, Australia
    Br J Pharmacol 139:415-23. 2003
    ..3 Devazepide (0.5 mg kg(-1), i.v...

Research Grants51

  1. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2001
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  2. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2003
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  3. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1999
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  4. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2000
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  5. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2002
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  6. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 2000
    ..of apo A-IV and determine that both of these responses are CCK-AR- dependent using the CCK-AR antagonist devazepide. A direct effect of Cck on vagal afferents innervating the gastro-duodenum will be determined by measuring ..
  7. FEEDBACK REGULATION OF PANCREATIC SECRETION
    Gary Green; Fiscal Year: 1991
    ..These data will help to understand and treat gastrointestinal diseases, particularly pancreatic and gallbladder diseases...
  8. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 2001
    ..Recent studies demonstrating that devazepide, a CCK-A receptor antagonist that penetrates the blood/brain barrier, stimulates feeding in a variety of species ..
  9. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 1999
    ..Recent studies demonstrating that devazepide, a CCK-A receptor antagonist that penetrates the blood/brain barrier, stimulates feeding in a variety of species ..
  10. MECHANISMS UNDERLYING MATERNAL CALMING AND ANALGESIA
    ELLIOTT BLASS; Fiscal Year: 1993
    ..They will also reveal potential lasting effects of these influences beyond their proximal effects. They will provide a basis for evaluating normal development and that of infants from abnormal populations (drug addiction, for example)...
  11. MECHANISMS UNDERLYING MATERNAL CALMING AND ANALGESIA
    ELLIOTT BLASS; Fiscal Year: 1991
    ..They will also reveal potential lasting effects of these influences beyond their proximal effects. They will provide a basis for evaluating normal development and that of infants from abnormal populations (drug addiction, for example)...
  12. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  13. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2008
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  14. VETERINARY STUDENT RESEARCH TRAINING PROGRAM
    KC LLOYD; Fiscal Year: 2008
    ..abstract_text> ..
  15. UCD KOMP Project Repository
    KC LLOYD; Fiscal Year: 2007
    ..org) requests for information. Products and services will be offered to requesting investigators for a reasonable fee, enabling us to cost recover for distribution and to develop a self supporting repository operation within 4 years. ..
  16. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  18. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  19. UCD KOMP Project Repository
    KC LLOYD; Fiscal Year: 2008
    ..org) requests for information. Products and services will be offered to requesting investigators for a reasonable fee, enabling us to cost recover for distribution and to develop a self supporting repository operation within 4 years. ..
  20. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2007
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  21. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC KENT LLOYD; Fiscal Year: 2010
    ..By enabling availability and access of such valuable mouse models to the entire research community, the UCD-MMRRC fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases. ..
  22. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC KENT LLOYD; Fiscal Year: 2010
    ..By enabling availability and access of such valuable mouse models to the entire research community, the UCD-MMRRC fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases. ..
  23. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC KENT LLOYD; Fiscal Year: 2010
    ..By enabling availability and access of such valuable mouse models to the entire research community, the UCD-MMRRC fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases. ..
  24. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2009
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  25. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC KENT LLOYD; Fiscal Year: 2010
    ..By enabling availability and access of such valuable mouse models to the entire research community, the UCD-MMRRC fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases. ..
  26. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2008
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  27. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2009
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  28. ADVANCED RESEARCH (YEAR) PROGRAM FOR VET STUDENTS
    KC LLOYD; Fiscal Year: 2007
    ..abstract_text> ..
  29. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  30. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  31. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 1999
    ....
  32. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2000
    ....
  33. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2001
    ....
  34. IL-lB and Meal Patterns: Ovarian Hormones and CCK
    PETER BUTERA; Fiscal Year: 2002
    ....
  35. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2003
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. ..
  36. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..
  37. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2005
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. ..
  38. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2005
    ..These relationships allow leveraging of MMRRC support, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  39. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2006
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  40. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2006
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT ..
  41. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2007
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  42. UCD MUTANT MOUSE REGIONAL RESOURCE CENTER
    KC LLOYD; Fiscal Year: 2007
    ..These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community. ..
  43. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..