Genomes and Genes
Summary: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Publications304 found, 100 shown here
- Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase geneSara Baumgartner-Sigl
Department of Pediatrics, Medical University Innsbruck, Austria
Bone 40:1655-61. 2007b>Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood. Typically, PRS and HPP are rare, independent, metabolic disorders...
- Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidantsP Bilski
Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
Photochem Photobiol 71:129-34. 2000Vitamin B6 (pyridoxine, 1) and its derivatives: pyridoxal (2), pyridoxal 5-phosphate (3) and pyridoxamine (4) are important natural compounds involved in numerous biological functions...
- Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)Philippa B Mills
Institute of Child Health, University College London with Great Ormond Street Hospital for Children, National Health Service Trust, London, UK
Brain 133:2148-59. 2010b>Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of l-alpha-aminoadipic ..
- Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathyTracyAnn Perry
Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Exp Neurol 203:293-301. 2007b>Pyridoxine (vitamin B6) intoxicated rodents develop a peripheral neuropathy characterized by sensory nerve conduction deficits associated with disturbances of nerve fiber geometry and axonal atrophy...
- The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1Gunter Scharer
Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
J Inherit Metab Dis 33:571-81. 2010b>Pyridoxine-dependent epilepsy is a disorder associated with severe seizures that may be caused by deficient activity of α-aminoadipic semialdehyde dehydrogenase, encoded by the ALDH7A1 gene, with accumulation of α-aminoadipic ..
- Characterization of endoperoxide and hydroperoxide intermediates in the reaction of pyridoxine with singlet oxygenBrian K Ohta
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
J Am Chem Soc 124:12064-5. 2002The photosensitized oxidation of vitamin B6, pyridoxine, is investigated by product and kinetic analysis...
- Update on interconversions of vitamin B-6 with its coenzymeD B McCormick
Department of Biochemistry, Rollins Research Center, Emory University, Atlanta, GA 30322 3050, USA
J Nutr 129:325-7. 1999..pyridoxal (pyridoxine, pyridoxamine) kinase and pyridoxine (pyridoxamine) phosphate oxidase...
- Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluriaCarla G Monico
Mayo Clinic Hyperoxaluria Center, Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Am J Nephrol 25:183-8. 2005..Approximately half of PHI patients experience improvement in the degree of hyperoxaluria following pyridoxine (VB6) treatment...
- Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric ratsLakshminarasimhan Vidya
Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India
Phytother Res 16:514-8. 2002..Administration of a pyridoxine deficient diet containing 3% glycollic acid for 21 days led to increased excretion of stone forming constituents ..
- Ginkgo biloba and ginkgotoxinEckhard Leistner
Institut for Pharmazeutische Biologie der Rheinischen Friedrich Wilhelms Universität Bonn, Nussallee 6, D 53115 Bonn, Germany
J Nat Prod 73:86-92. 2010..biloba products. The present paper summarizes recent experiences with G. biloba and its derived products and explains why their restricted use is recommended...
- The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo bilobaUta Kästner
Institut fur Pharmazeutische Biologie, Universitat Bonn, Germany
FEBS J 274:1036-45. 2007..serves as an alternate substrate for this enzyme with a lower K(m) value than pyridoxal, pyridoxamine or pyridoxine. Thus, the presence of ginkgotoxin leads to temporarily reduced pyridoxal phosphate formation in vitro and ..
- Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology GroupP H Wiernik
Albert Einstein Cancer Center, Bronx, New York
Cancer Invest 10:1-9. 1992..v. on Day 1 at a dose of 37.5 mg/m2 (regimens A and B) or 75 mg/m2 (regimens C and D). In addition, since pyridoxine administration has been reported to reduce the neurotoxicity of HMM, that agent was given at a dose of 300 mg/m2 ..
- Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant alleleCarla G Monico
Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
Kidney Int 67:1704-9. 2005b>Pyridoxine (VB6) response in type I primary hyperoxaluria (PHI) is variable, with nearly equal numbers of patients showing partial to complete reductions in oxaluria, and resistance...
- Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled studyYoon Koo Kang
Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, 138 736 Korea
J Clin Oncol 28:3824-9. 2010To determine whether concurrent pyridoxine therapy can prevent the development of hand-foot syndrome (HFS) in patients being treated with capecitabine.
- B6-responsive disorders: a model of vitamin dependencyPeter T Clayton
Biochemistry, Endocrinology and Metabolism, Institute of Child Health, 30 Guilford St, London, WC1N 1 EH, UK
J Inherit Metab Dis 29:317-26. 2006..There are several different mechanisms that lead to an increased requirement for pyridoxine and/or pyridoxal phosphate...
- Pyridoxine biosynthesis in yeast: participation of ribose 5-phosphate ketol-isomeraseHiroki Kondo
Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Kawazu 680 4, Iizuka 820 8502, Japan
Biochem J 379:65-70. 2004To identify the genes involved in pyridoxine synthesis in yeast, auxotrophic mutants were prepared...
- PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolismMorad Khayat
Institute of Medical Genetics, Western Galilee Hospital, Nahariya, P O Box 21, 22100 Nahariya, Israel
Mol Genet Metab 94:431-4. 2008The rare autosomal recessive disorder pyridoxine 5'-phosphate oxidase (PNPO) deficiency is a recently described cause of neonatal and infantile seizures...
- Dose-dependent effects of glutamate in pyridoxine-induced neuropathyTarinee Arkaravichien
Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand
Food Chem Toxicol 41:1375-80. 2003In order to explore the effects of glutamate in a pyridoxine megadose-induced neuropathy, rats were received glutamate either 0.5 or 1 g/kg/day orally with or without pyridoxine 0.8 g/kg/day intraperitoneally for 14 days...
- Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effectMadhu B Garg
Department of Medical Oncology, Calvary Mater Newcastle Hospital, Locked Bag No 7, Hunter Regional Mail Centre, Newcastle, NSW 2310, Australia
Cancer Chemother Pharmacol 67:963-6. 2011..Reversible, cumulative, peripheral sensory neuropathy is the principal dose-limiting toxicity of OHP therapy. Pyridoxine (vitamin B6) has been shown to reduce cisplatin and fluoropyrimidine-related neurotoxicity but its ..
- Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathwaysG Mittenhuber
Institut fur Mikrobiologie und Molekularbiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
J Mol Microbiol Biotechnol 3:1-20. 2001..This proposal might help to explain why the PdxA/PdxJ pathway is largely restricted to this subdivision...
- Combination effects of sodium butyrate and pyridoxine treatment on cell proliferation and neuroblast differentiation in the dentate gyrus of D-galactose-induced aging model miceDae Young Yoo
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
Neurochem Res 37:223-31. 2012We previously reported that sodium butyrate (SB), a histone deacetylase inhibitor, robustly increased pyridoxine-induced cell proliferation and neuroblast differentiation in the dentate gyrus of the adult mouse...
- S250F variant associated with aromatic amino acid decarboxylase deficiency: molecular defects and intracellular rescue by pyridoxineRiccardo Montioli
Department of Life Sciences and Reproduction, University of Verona, Verona, Italy
Hum Mol Genet 22:1615-24. 2013..Importantly, 4-phenylbutirric acid (4-PBA) or, to a major extent, pyridoxine increase the expression level and, in a dose-dependent manner, the decarboxylase specific activity of mutant-..
- Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2Magdalena Zielińska-Dawidziak
Department of Biotechnology and Food Microbiology, University of Life Sciences in Poznan
J Nutr Sci Vitaminol (Tokyo) 54:423-9. 2008In this study, we examined the intestinal uptake of thiamin (vitamin B(1)), riboflavin (vitamin B(2)) and pyridoxine (vitamin B(6)) administered at high concentration using intestinal epithelial Caco-2 cells as an in vitro model of drugs ..
- Ginkgo seed poisoningYo Kajiyama
Department of Pediatrics Kyoto Min i ren Central Hospital Kyoto, Japan
Pediatrics 109:325-7. 2002..Awareness of the potential danger of overconsumption of this traditional food and its prompt treatment with pyridoxal phosphate may hasten recovery...
- Beta-glucosidase, exo-beta-glucanase and pyridoxine transglucosylase activities of rice BGlu1Rodjana Opassiri
Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
Biochem J 379:125-31. 2004..b>Pyridoxine 5'-O-beta-D-glucoside was the most efficiently hydrolysed natural glycoside tested...
- Pyridoxine uptake by colonocytes: a specific and regulated carrier-mediated processZainab M Said
Department of Medicine and Physiology, University of California, Irvine, California, USA
Am J Physiol Cell Physiol 294:C1192-7. 2008The water-soluble vitamin B6 (pyridoxine) is important for normal cellular functions, growth, and development...
- An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growthG Zhao
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston 77030 1501
J Bacteriol 176:6134-8. 1994..tktB double mutant, which is devoid of the two known transketolase isoenzymes of Escherichia coli K-12, requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth...
- Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular StudyWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
Arch Intern Med 169:335-41. 2009..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy.
- Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo-controlled studyMarcelo M Nascimento
Faculdade Evangélica do Paraná Brazil, Parana, Brazil
J Ren Nutr 16:119-24. 2006To study the effect of high doses of thiamine (250 mg/day) and pyridoxine (200 mg/day) supplementation on plasma levels of advanced glycation end products and other oxidative stress markers in hemodialysis patients.
- Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathyNazanin Noori
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Int J Vitam Nutr Res 83:77-85. 2013This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in ..
- Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolidAlex Soriano
Department of Infectious Diseases, Hospital Clinic of Barcelona, C Villarroel 170, Barcelona 08036, Spain
Antimicrob Agents Chemother 51:2559-63. 2007..The aim of this study was to evaluate the influences of pyridoxine, rifampin, and renal function on hematological adverse events...
- Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsyRenata C Gallagher
Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado at Denver, CO, USA
Ann Neurol 65:550-6. 2009Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy...
- Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UKP Baxter
Ryegate Centre, Sheffield Children s Hospital, Tapton Crescent, Sheffield S10 5DD, UK
Arch Dis Child 81:431-3. 1999To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures.
- Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patientsCraig L Bennett
Division of Genetics and Developmental Medicine, Department of Pediatrics, University of Washington, and Children s Hospital and Regional Medical Center, Seattle, Washington 98195 6320, USA
Epilepsia 50:1167-75. 2009b>Pyridoxine-dependent seizure (PDS) is a rare disorder characterized by seizures that are resistant to common anticonvulsants, and that are ultimately controlled by daily pharmacologic doses of pyridoxine (vitamin B6)...
- Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsyH S Wang
Division of Pediatric Neurology, Chang Gung Children s Hospital, and Medical College of Chang Gung University, Taoyuan, Taiwan
Arch Dis Child 90:512-5. 2005To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children.
- Current knowledge concerning optimum nutritional status of riboflavin, niacin and pyridoxineH J Powers
Division of Child Health, University of Sheffield, Sheffield Children s Hospital, UK
Proc Nutr Soc 58:435-40. 1999..The present short review considers the current position regarding such markers for riboflavin, pyridoxine and niacin...
- Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalaminM Naruszewicz
Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, and the Dialysis Unit of the Provincial Hospital, Szczecin, Poland
Metabolism 50:131-4. 2001..Folic acid (15 mg/d), pyridoxine (150 mg/d), and cyanocobalamin (1 mg/wk) were administered for 4 weeks in 21 patients receiving dialysis, and a ..
- A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31V Cormier-Daire
Department of Medical Genetics and INSERM U393, Hopital Necker Enfants Malades, 75015 Paris, France
Am J Hum Genet 67:991-3. 2000b>Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by generalized seizures in the first hours of life and responding only to pyridoxine hydrochloride...
- Epidemiology of pyridoxine dependent seizures in the NetherlandsJ V Been
Department of Paediatrics, Maastricht University Hospital, Netherlands
Arch Dis Child 90:1293-6. 2005b>Pyridoxine dependent epilepsy is a rare cause of seizures in childhood. The diagnosis is made on clinical criteria, that in many cases are never met. Therefore, epidemiological data on pyridoxine dependency are scarce.
- Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelosePretty Mary Abraham
Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
J Biomed Sci 17:78. 2010..The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the hippocampal 5-HT, 5-HT(2A) receptor subtype, gene expression studies on 5-HT(2A), 5-HTT, INSR, ..
- Thiamine, riboflavin, pyridoxine, and vitamin C status in premature infants receiving parenteral and enteral nutritionJ K Friel
Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland A1B 3X9, Canada
J Pediatr Gastroenterol Nutr 33:64-9. 2001..There is a paucity of data about water soluble vitamin status in low birthweight infants. Therefore, the authors' objective was to assess current feeding protocols...
- Electroencephalographic changes in pyridoxine-dependant epilepsy: new observationsGeorges Naasan
Department of Pediatrics, American University of Beirut, Medical Center, Beirut, Lebanon
Epileptic Disord 11:293-300. 2009b>Pyridoxine-dependent epilepsy (PDE) is a rare disease, of which the EEG manifestations are only partially characterised. We report our observations of EEG recordings in four patients with PDE.
- Multiple mechanisms of action of pyridoxine in primary hyperoxaluria type 1Sonia Fargue
Department of Cell and Developmental Biology, University College London, London, UK
Biochim Biophys Acta 1832:1776-83. 2013..About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin B6), but its mechanism of action is unknown...
- Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin)Simerpal Kaur Gill
The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Ther Drug Monit 33:115-9. 2011Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada...
- Polyneuropathy, anti-tuberculosis treatment and the role of pyridoxine in the HIV/AIDS era: a systematic reviewJ J Van der Watt
Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 15:722-8. 2011..the development of a painful isoniazid (INH) associated polyneuropathy (PN), which is preventable with adequate pyridoxine supplementation...
- Effects of dietary pyridoxine on haemato-immunological responses of Labeo rohita fingerlings reared at higher water temperatureM S Akhtar
Division of Fish Nutrition, Biochemistry and Physiology, Central Institute of Fisheries Education, Versova, Mumbai, India
J Anim Physiol Anim Nutr (Berl) 96:581-90. 2012A sixty-day feeding trial was carried out to elucidate the effect of dietary pyridoxine (PN) on hemato-immunological parameters in Labeo rohita fingerlings exposed to an elevated temperature (ET) of 33 °C...
- Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectorisArve Ulvik
Bevital A S, Laboratoriebygget, Bergen, Norway
Am J Clin Nutr 95:1072-8. 2012..A negative association between systemic markers of inflammation and plasma vitamin B-6 has been observed in population-based and patient cohorts; however, vitamin B-6 (pyridoxine) treatment has mostly failed to improve inflammatory indexes.
- Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatmentHizir Ulvi
Firat University Medical Faculty, Department of Neurology, Elazig, Turkey
J Trop Pediatr 48:303-6. 2002b>Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of neonatal onset...
- Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancyMaged M Costantine
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA
Ther Drug Monit 34:569-73. 2012..The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP).
- Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancyIlan Matok
University of Toronto, Toronto, Ontario, Canada
J Clin Pharmacol 53:334-8. 2013Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described...
- Pyridoxine restores endothelial cell function in high glucoseBret G Kelso
School of Biological and Health Systems Engineering, Fulton Schools of Engineering, Arizona State University, Tempe, Arizona 85287 9709, USA
Metab Syndr Relat Disord 9:63-8. 2011..This study tests whether aminoguanidine can also restore migratory ability of endothelial cells and whether pyridoxine, a stable form of vitamin B6, can restore migratory ability and ability to align and elongate in response to ..
- The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsyLevinus A Bok
Department of Pediatrics, Maxima Medical Center, Veldhoven, The Netherlands
Epilepsia 51:2406-11. 2010b>Pyridoxine-dependent epilepsy (PDE) is characterized by therapy-resistant seizures (TRS) responding to intravenous (IV) pyridoxine...
- The effect of a subnormal vitamin B-6 status on homocysteine metabolismJ B Ubbink
Department of Chemistry Pathology, University of Pretoria, South Africa
J Clin Invest 98:177-84. 1996..01) reduced in both groups after vitamin supplementation. It is concluded that a vitamin B-6 deficiency may contribute to impaired transsulfuration and an abnormal methionine load test, which is associated with premature vascular disease...
- Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathyTracy Ann Perry
Section of Drug Design and Development, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Neurol 190:133-44. 2004Excess ingestion of pyridoxine (vitamin B6) causes a severe sensory neuropathy in humans. The mechanism of action has not been fully elucidated, and studies of pyridoxine neuropathy in experimental animals have yielded disparate results...
- Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein-deficient dietSeymour Levine
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Appl Toxicol 24:497-500. 2004Large doses of pyridoxine cause injury to the primary sensory neurons in trigeminal and dorsal root ganglia of animals and patients subjected to megavitamin therapy...
- Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism?Tsung Tair Yang
Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
J Pharmacol Exp Ther 331:244-54. 2009b>Pyridoxine (vitamin B(6)) protects neurons against neurotoxicity. An excessive release of glutamate is widely considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases...
- Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+)Jurgen Stolz
Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
Eukaryot Cell 4:319-26. 2005..Here we isolated car1+ by complementation of Saccharomyces cerevisiae mutants that are deficient in pyridoxine biosynthesis and uptake...
- The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancyG Atanackovic
Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, Toronto, Canada
J Clin Pharmacol 41:842-5. 2001A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada...
- Pyridoxine-induced neuropathy in rats: a sensory neuropathy that responds to 4-methylcatecholN Callizot
Société Neurofit SA, Immeuble le Platon, rue Jean Sapidus, F 67400 Illkirch, France
Neurobiol Dis 8:626-35. 2001..to induce a nonlethal, exclusively sensory, reversible neuropathy by intoxicating rats with large amounts of pyridoxine, using a new schedule of intoxication; (b) 4-methylcatechol, a drug known to induce nerve growth factor ..
- A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathwayHamid M Said
Veterans Affairs Medical Center 151, Long Beach, CA 90822, USA
Am J Physiol Cell Physiol 285:C1219-25. 2003..To test this hypothesis, we examined pyridoxine transport in a model system for human enterocytes, the human-derived intestinal epithelial Caco-2 cells...
- A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemiaH Harigae
Department of Clinical Medicine, Tohoku University School of Medicine, Sandai, Japan
Am J Hematol 62:112-4. 1999..5 of the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) was identified in a Japanese male with pyridoxine-responsive sideroblastic anemia...
- Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injuryZheng Bei Wang
Department of Neurobiology, Parker Research Institute, 2500 Walnut Hill Lane, Dallas, TX 75229, USA
Pain 114:266-77. 2005..The present study investigated the analgesic roles of the B vitamins thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ..
- Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmineLars Muller
Department of Pediatric Hematology and Oncology, University Medical Center, Heinrich Heine University, Dusseldorf, Germany
Pediatr Blood Cancer 42:287-8. 2004
- Isoniazid toxicity presenting as seizures and metabolic acidosisR C Watkins
Department of Emergency Medicine, Howard University Hospital, Washington, DC 20060
J Natl Med Assoc 82:57, 62, 64. 1990..are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces ..
- A double-blind, randomized trial of pyridoxine versus placebo for the prevention of pegylated liposomal doxorubicin-related hand-foot syndrome in gynecologic oncology patientsVivian von Gruenigen
Department of Obstetrics and Gynecology, Summa Akron City Hospital, Akron, Ohio 44309 2090, USA
Cancer 116:4735-43. 2010The objective of this study was to compare the incidence of hand-foot syndrome (HFS) in patients who received pyridoxine versus placebo during pegylated liposomal doxorubicin (PLD) chemotherapy for recurrent ovarian, breast, or ..
- Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levelsLevinus A Bok
Department of Paediatrics, Maxima Medical Center, Veldhoven, The Netherlands
Arch Dis Child 92:687-9. 2007b>Pyridoxine-dependent seizures (PDS) is a rare, autosomal recessively inherited disorder...
- Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathyHamit Ozyurek
Ondokuz Mayis University, Faculty of Medicine, Department of Pediatrics, Section of Neurology, Samsun, Turkey
Pediatr Hematol Oncol 24:447-52. 2007..The patient seemed to benefit from pyridoxine and pyridostigmine therapy greatly and this therapy is recommended in patients with severe vincristine-induced ..
- Identification of a new tetrameric pyridoxal 4-dehydrogenase as the second enzyme in the degradation pathway for pyridoxine in a nitrogen-fixing symbiotic bacterium, Mesorhizobium lotiNana Yokochi
Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
Arch Biochem Biophys 452:1-8. 2006..loti cells could grow in a nutrient-rich TY medium but not in a synthetic one containing pyridoxine or pyridoxamine as the sole carbon and nitrogen source...
- Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trialGideon Koren
Motherisk Program, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Am J Obstet Gynecol 203:571.e1-7. 2010To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy.
- Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in manVirpi Saareks
Department of Pharmacological Sciences, University of Tampere, Finland
Pharmacol Toxicol 90:338-42. 2002The effects of nicotinic acid (2500 mg orally during 12 hr) and pyridoxine (300 mg orally twice daily for seven days) on the excretion of urinary 2,3-dinor-6-ketoprostaglandin F1alpha, 11-dehydrothromboxane B2 and leukotriene E4, the ..
- Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell diseaseVinod V Balasa
Cincinnati Comprehensive Sickle Cell Center of the Division of Hematology Oncology, Children s Hospital Medical Center, Ohio 45229, USA
J Pediatr Hematol Oncol 24:374-9. 2002..Plasma methylmalonic acid and pyridoxine levels were determined in 54 patients and all controls...
- Metabolism of vitamin B-6 by human liverA H Merrill
J Nutr 114:1664-74. 1984..b>Pyridoxine (pyridoxamine) 5'-phosphate oxidase (EC 1.4.3...
- Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing ageIrena Nulman
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
Can J Clin Pharmacol 16:e400-6. 2009The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983...
- Identification of the pdxK gene that encodes pyridoxine (vitamin B6) kinase in Escherichia coli K-12Y Yang
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School 77030 1501, USA
FEMS Microbiol Lett 141:89-95. 1996We isolated a miniTn10(Cmr) insertion mutant lacking pyridoxine (PN) kinase and cloned the structural gene, designated pdxK, by complementation...
- Pyridoxine improves platelet nitric oxide synthase dysfunction induced by advanced glycation end products in vitroYi Han
Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Int J Vitam Nutr Res 80:168-77. 2010..The aims of this study were to determine in vitro whether pyridoxine can abrogate the impairment in platelet NOS activity caused by AGEs, and to determine the mechanism by which it ..
- Automatic postural responses are delayed by pyridoxine-induced somatosensory lossPaul J Stapley
Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006 3499, USA
J Neurosci 22:5803-7. 2002b>Pyridoxine given in large doses is thought to destroy selectively the large-diameter peripheral sensory nerve fibers, leaving motor fibers intact...
- Ginkgo nut intoxication in a 2-year-old maleShunji Hasegawa
Department of Allergy, Yamaguchi University, School of Medicine, and Department of Hospital Pharmacy, Niigata City General Hospital, Japan
Pediatr Neurol 35:275-6. 2006..After the treatment, his symptoms were resolved. The neurotoxicity of ginkgo nuts should be recognized by pediatricians and parents who have infants...
- Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humansJian Cui
Penn State Heart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
J Physiol 589:685-95. 2011..this study, young healthy volunteers performed fatiguing isometric handgrip before and after a local infusion of pyridoxine (i.e. vitamin B(6)) into the 'isolated' circulation of the human forearm...
- Randomized trial of two different doses of pyridoxine in the prevention of capecitabine-associated palmar-plantar erythrodysesthesiaT Chalermchai
Medical Oncology Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Asia Pac J Clin Oncol 6:155-60. 2010The aim of the present study was to compare the efficacy of 200 mg versus 400 mg daily of pyridoxine in preventing or delaying the onset of palmar-plantar erythrodysesthesia (PPE) in capecitabine-treated patients.
- A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modificationsP G Corrie
Oncology Division, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Br J Cancer 107:585-7. 2012b>Pyridoxine is frequently used to treat capecitabine-induced hand-foot syndrome (HFS), although the evidence of benefit is lacking...
- R411C mutation of the ALAS2 gene encodes a pyridoxine-responsive enzyme with low activityK Furuyama
Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
Br J Haematol 103:839-41. 1998..the erythroid-specific delta-aminolaevulinate synthase (ALAS2) gene was identified in a pedigree with X-linked pyridoxine-responsive sideroblastic anaemia (XLSA). The normal and the mutant cDNAs were expressed in E...
- Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrusDae Young Yoo
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
Neurochem Res 36:1850-7. 2011We previously observed that pyridoxine (vitamin B(6)) significantly increased cell proliferation and neuroblast differentiation without any neuronal damage in the hippocampus...
- Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysisWei Ping Tai
Department of Gastroenterology, Guangdong No 2 Provincial People s Hospital, Guangzhou, China
Adv Ther 25:1085-8. 2008..Initial treatment with large doses of pyridoxine (for 6 hours) failed to awaken this patient...
- Pipecolic acid: a diagnostic marker in pyridoxine-dependent epilepsyMichel A A P Willemsen
Ann Neurol 58:653. 2005
- Pyridoxine-dependent seizures associated with hypophosphatasia in a newbornMagda Lahorgue Nunes
Division of Neurology, Hospital Sao Lucas, PUCRS School of Medicine, Porto Alegre RS, Brazil
J Child Neurol 17:222-4. 2002b>Pyridoxine dependency and congenital hypophosphatasia are unusual metabolic disorders. We report a female infant born from healthy consanguineous parents with shortening of limbs, detected during pregnancy by ultrasonography...
- Gene identification and characterization of the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid amidohydrolase from Mesorhizobium loti MAFF303099Baiqiang Yuan
Department of Bioresources Science, Faculty of Agriculture, Kochi University, Nankoku, Kochi, Japan
J Nutr Sci Vitaminol (Tokyo) 54:185-90. 2008We have found for the first time that a chromosomal gene, mlr6787, in Mesorhizobium loti encodes the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid (AAMS) amidohydrolase...
- Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: antidotal effect of pyridoxineE Sreekumaran
Department of Life Sciences, University of Calicut, Kerala, India
Brain Res Bull 59:421-7. 2003..These perturbations are reversed by supplementing the feed with pyridoxine (8 mg/kg) for 30 days...
- Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatographyKe Li
The Center of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, Jiangsu, People s Republic of China
Biomed Chromatogr 16:504-7. 2002..liquid chromatographic method (HPLC) has been developed and validated for the routine analysis of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets...
- Pyridoxine-dependent seizures: a clinical and biochemical conundrumPeter Baxter
Ryegate Centre Paediatric Neurology, Sheffield Childrens Hospital, Tapton Crescent Road, Sheffield S10 5DD, UK
Biochim Biophys Acta 1647:36-41. 2003b>Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood...
- Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary resultsPhilippe Major
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Epilepsy Behav 13:557-9. 2008..Patients followed in our center have reported improvement of these side effects after starting pyridoxine (vitamin B(6)) supplements...
- Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal useDaniela O Ribeiro
Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
Nutr J 10:47. 2011....
- Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometryMario Aranda
Institute of Food Chemistry, University of Hohenheim, Garbenstrasse 28, D 70599 Stuttgart, Germany
J Chromatogr A 1131:253-60. 2006A new high-throughput method was developed to detect simultaneously riboflavin (Vitamin B(2)), pyridoxine (Vitamin B(6)), nicotinamide (Vitamin B(3)), caffeine and taurine in energy drinks by multiple detection...
- The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plantsMikael Ristilä
School of Science and Technology and Örebro Life Science Centre, Orebro University, Orebro, Sweden
Plant Physiol Biochem 49:284-92. 2011..Some plant UV-B responses are related to the formation of reactive oxygen species (ROS) and pyridoxine (vitamin B(6)) has been reported to be a quencher of ROS...
- Vitamin B6 nutritional status in asthma: the effect of theophylline therapy on plasma pyridoxal-5'-phosphate and pyridoxal levelsR Delport
Department of Chemical Pathology, University of Pretoria, South Africa
Int J Vitam Nutr Res 58:67-72. 1988..An in vitro study showed that theophylline did not interfere with the high performance liquid chromatography assay for pyridoxal-5'-phosphate, indicating that theophylline could affect liver metabolism of vitamin B6...
- Properties and interaction of heterologously expressed glutamate decarboxylase isoenzymes GAD(65kDa) and GAD(67kDa) from human brain with ginkgotoxin and its 5'-phosphateK Buss
, , Nussallee 6, 53115 Bonn, Germany
J Med Chem 44:3166-74. 2001....
- Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy oP Dusitanond
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Stroke 36:144-6. 2005....
- High-yielding enzymatic alpha-glucosylation of pyridoxine by marine alpha-glucosidase from Aplysia fasciataAnnabella Tramice
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80072 Pozzuoli, Naples, Italy
Mar Biotechnol (NY) 8:448-52. 2006..High-yielding enzymatic alpha-glycosylation of pyridoxine using this marine enzyme is reported here; the reaction has been optimized, reaching 80% molar yield of products ..
- Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatmentSidney M Gospe
Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA 98105, USA
Curr Opin Neurol 19:148-53. 2006b>Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood...
- Mutation and polymorphic marker analyses of 65K- and 67K-glutamate decarboxylase genes in two families with pyridoxine-dependent epilepsyS Kure
Department of Biochemical Genetics, Tohoku University School of Medicine, Sendai, Japan
J Hum Genet 43:128-31. 1998b>Pyridoxine-dependent epilepsy is a disease inherited as an autosomal recessive trait, characterized by rapid response to pharmacological dosages of pyridoxine...
- Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative GD W Newling
Free University Hospital, Department of Urology, Amsterdam, The Netherlands
Eur Urol 27:110-6. 1995This double-blind randomised phase III trial was designed to assess the effect of pyridoxine administration on the recurrence of Ta and T1 transitional cell tumours of the bladder...
- Isolation of PDX2, a second novel gene in the pyridoxine biosynthesis pathway of eukaryotes, archaebacteria, and a subset of eubacteriaM Ehrenshaft
Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695, USA
J Bacteriol 183:3383-90. 2001In this paper we describe the isolation of a second gene in the newly identified pyridoxine biosynthesis pathway of archaebacteria, some eubacteria, fungi, and plants...
- Cystathionine beta synthase (CBS) and angiogenesisPriyabrata Mukherjee; Fiscal Year: 2013....
- Maternal One Carbon Metabolism and Low Birth Weight InfantSatish C Kalhan; Fiscal Year: 2013..document maternal methionine, homocysteine metabolism, relate it to nutrient (protein) intake, folate, B12, pyridoxine status, and measures of insulin resistance...
- Vitamin B6 Effects on One-Carbon MetabolismJesse F Gregory; Fiscal Year: 2013..kinetic and metabolomic assessments will be conducted in OC users before and after supplementation with pyridoxine to allow a thorough functional evaluation of unsupplemented OC users and the metabolic restoration provided by ..
- The role of GABA-mimetic metabolites in neurodevelopmental and neuropsychiatric dJoseph A Gogos; Fiscal Year: 2013..porphyria, a disease associated with psychosis and seizures, and L-pipecolic acid, which accumulates in pyridoxine (vitamin B6) dependent epilepsy, a disease associated with seizures...
- Ninth International Primary Hyperoxaluria WorkshopRoss P Holmes; Fiscal Year: 2010..There is no known cure apart from a small percentage of individuals who respond completely to pyridoxine therapy...
- VITAMIN B2 AND B6 IN VERY LOW BIRTH WEIGHT INFANTSLARRY SWIFT; Fiscal Year: 1992..riboflavin and marked increases in plasma B6 vitamers were also noted with the current recommended dose of pyridoxine. Both findings appear to be due in part to renal and hepatic immaturity...
- Bioactivity and Vitamins in Flash-heated BreastmilkCaroline Chantry; Fiscal Year: 2005..unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and digestability of proteins lysozyme ..
- REGULATION OF PYRIDOXAL PHOSPHATE BIOSYNTHESIS IN E COLIMalcolm Winkler; Fiscal Year: 1999..for these physiological, genetic, and biochemical studies, because it synthesizes a form of the PLP-precursor, pyridoxine (PN; vitamin B6), like plants and certain other microorganisms, and can convert PN, pyridoxal (PL), and ..
- GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINEWarren Kruger; Fiscal Year: 2009..Some CBS-deficient patients respond clinically to pharmacologic doses of pyridoxine (vitamin B6)...
- Hyperhomocysteinemia in Alzheimer's DiseaseRamon Diaz Arrastia; Fiscal Year: 2003..Since vitamin supplementation with folic acid, vitamin B12, and pyridoxine can lower homocysteine levels, this association raises the exciting possibility that polyvitamin therapy may ..
- VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGETerry Shultz; Fiscal Year: 2002..Vitamin B-6 metabolite concentrations [i.e., pyridoxal phosphate (PLP), pyridoxamine phosphate, pyridoxal, pyridoxine and 4-pyridoxic acid] will be determined in plasma and erythrocytes, and PLP concentrations measured in ..
- EFFICACY OF TB CHEMOPROPHYLAXIS IN PPD, HIV ADULTSJacqueline Coberly; Fiscal Year: 1999..Eligible residents of Cite Soleil (n=345) will be randomized to receive isoniazid and pyridoxine (B6) daily for six months, rifampin and B6 daily for three months followed by daily B6 for three months, or B6 ..
- PERTURBATIONS IN VITAMIN B6 METABOLISM IN CANCERLOUISE NUTTER; Fiscal Year: 2000..In particular, pyridoxine 5'- phosphate oxidase (PNPO), the rate limiting enzyme in the synthesis of the active form of vitamin B6 (i.e...
- NUTRITIONAL PROPERTIES OF PYRIDOXINE-BETA-GLUCOSIDEJESSE GREGORY; Fiscal Year: 2001DESCRIPTION: Pyridoxine-beta-glucoside (PNG) is a major component of vitamin B6 (B6) in plant foods, and PNG hydrolysis catalyzed by PNG hydrolase is rate limiting for the in vivo utilization...
- REGULATION OF MAMMALIAN PYRIDOXAL PHOSPHATE METABOLISMMARGARET FONDA; Fiscal Year: 1980..These are aldehyde oxidase from mammalian liver and pyridoxine-P oxidase and vitamin B6-P phosphatase from human erythrocytes...
- 5-Aminolevulinate Synthase and Heme BiosynthesisGloria Ferreira; Fiscal Year: 2006..The prospect of developing pyridoxine-based therapies of universal efficacy for XLSA relies on the knowledge of the mechanism of ALAS, the cofactor-..
- VITAMIN B-6 NUTRITIONAL STATUS ASSESSMENT IN PREGNANCYAndrew Smolen; Fiscal Year: 1993..Mice will be fed one of five dietary levels of vitamin B-6 (pyridoxine-Hcl) to determine the effect of dietary intake on these nutritional status indices...
- LONG ORAL CONTRACEPTIVE USE/VITAMIN B-6 PREGNANCY NEEDSAvanelle Kirksey; Fiscal Year: 1980..Subjects will be randomly assigned to four groups to receive supplements of 2.5, 5, l0, or 15 mg pyridoxine/day...
- NEURAL CONTROL OF POSTURE AND STANCEJANE MACPHERSON; Fiscal Year: 2002..somatosensory afferents in balance using a novel model of peripheral sensory neuropathy, in which a high dose of pyridoxine (vitamin B6) is used to induce widespread deafferentation...
- THE GENETICS OF PREGNANCY-INDUCED SEIZURES IN MICEAndrew Smolen; Fiscal Year: 1992..study the effects of vitamin B6 nutriture on brain neurochemistry in pregnancy by adjusting the dietary level of pyridoxine. Two strains of mice which differ in susceptibility to pregnancy-induced seizures will be used to study the ..
- VITAMIN INTERVENTION FOR STROKE PREVENTION (VISP)James Toole; Fiscal Year: 2006..Treatment with a combination of folic acid, pyridoxine (vitamin B6) and cobalamin (vitamin B12) reduces plasma H(e) levels in most cases, restores endothelial function,..
- Vitamin B6 Biosynthesis: A study of the pdxJ MechanismVALERIE FRYDRYCHOWSKI BURKE; Fiscal Year: 2002..PdxJ, or pyridoxine 5'-phosphate synthase, is known to catalyze the condensation of 1 -aminoacetone-3-phosphate and 1 -deoxy-D-..
- Aromatic Metabolism: A Web of Biochemical NetworksRoy Jensen; Fiscal Year: 2006..synthesis, as well as the more remote relationships that also include folate biosynthesis (via 4-aminobenzoate), pyridoxine biosynthesis, and histidine biosynthesis...
- PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORSFernando Gomez Pinilla; Fiscal Year: 2002..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins.
- Psychosocial & Nutritional Associations with DepressionCRISTINA MERETE; Fiscal Year: 2006..Research with B vitamins suggests that folate, cobalamin and pyridoxine status correlate with depressive symptomatology...
- C elegans:a model to study intestinal water-soluble vitamins transport in vivoHAMID SAID; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanism/regulation of human intestinal thiamin uptakeHAMID SAID; Fiscal Year: 2008..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
- Role of 10-formyldihydrofolate in purine biosynthesisTsunenobu Tamura; Fiscal Year: 2004..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..
- Influence of genotype on urinary oxalate excretionCARLA MONICO; Fiscal Year: 2007..3) The effect of normal allelic variation at the AGT locus on urine oxalate excretion and pyridoxine responsiveness will be defined in a group of idiopathic calcium oxalate stone formers...
- Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic PatientsSushil K Jain; Fiscal Year: 2010..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
- Adjuvant Therapy for Vascular Inflammation in DiabetesSushil Jain; Fiscal Year: 2006..abstract_text> ..
- Vascular factors, amyloid beta, and Alzheimer's diseaseJose Luchsinger; Fiscal Year: 2004..abstract_text> ..
- Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- New DHFR Deletion Polymorphism - A Risk Factor for SB?William Johnson; Fiscal Year: 2003..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
- Arterial stiffness, blood pressure and cognitionMerrill Elias; Fiscal Year: 2009....
- Function and regulation of cardiac uncoupling proteinsRaymond Russell; Fiscal Year: 2009..It is anticipated that the results of these studies will yield important insights into the role of UCPs in the clinically important disorders of myocardial ischemia/reperfusion and heart failure. ..
- EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODEDavid Nix; Fiscal Year: 2009..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
- Pilot Trial of Metformin in Amnestic MCIJose A Luchsinger; Fiscal Year: 2010....
- Sulfur Amino Acid Metabolism in NAFLDSatish C Kalhan; Fiscal Year: 2010..The proposed studies are aimed at examining the metabolic mechanisms involved in the progression of this disease, so that specific targeted intervention strategies related to the stage of the disease can be identified and evaluated. ..
- Osteoporosis in Hypercalciuric Kidney Stone FormersJohn Asplin; Fiscal Year: 2003..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 2002....
- FASEB Summer Conference: Folate, B12 and 1C MetabolismJAMES FINKELSTEIN; Fiscal Year: 2002..The format encourages discussions between the presenters and the fellows, residents and junior investigators in attendance. Similarly, the poster sessions also highlight the activities and the needs of the younger participants. ..
- AGE, RISK FACTORS FOR CVD AND COGNITIVE FUNCTIONINGMerrill Elias; Fiscal Year: 2002....
- Nutritional/Inflammatory Evaluation of Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2005....
- ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENTJulio Licinio; Fiscal Year: 2005..Discontinuation of this study would be highly deleterious, not only for the patients, but also for our understanding of the long-term effects of leptin in humans. ..
- Regulation of energy metabolism in the failing heartRaymond Russell; Fiscal Year: 2005..The findings of these studies will help to characterize the defects in energy metabolism in the failing heart and aid in the design of therapies that improve energy transduction in the failing human heart. ..
- Developing Educational Approaches for Mexican-AmericansJulio Licinio; Fiscal Year: 2005..Their input will also be incorporated into the article that will be submitted to a peer-reviewed journal. ..
- Studies of Human Folate HydrolaseCharles Halsted; Fiscal Year: 2005..abstract_text> ..
- SAMe and Folate Deficiency in Alcoholic MircropigsCharles Halsted; Fiscal Year: 2006..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
- Dietary Factors in Eye DiseaseWilliam Christen; Fiscal Year: 2006..Thus, the proposed analyses represent an extremely cost-effective opportunity to compare directly the predictive ability of several potentially modifiable risk factors for ARM and cataract in women and men. ..
- Flavocoxid: A Medical Food Therapy for OsteoarthritisSarah Morgan; Fiscal Year: 2004..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
- Glutamine Metabolism in the Human NewbornSatish Kalhan; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .............................................................................................................................................. 1 Description, ..
- New CVD risk factors for lowered congitive functioningMerrill Elias; Fiscal Year: 2005....
- EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASECharles Halsted; Fiscal Year: 2007..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
- Neuroactive Steroid Therapy of Catamenial EpilepsyDOODIPALA REDDY; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Eye Disease in a Trial of Selenium and Vitamin EWilliam Christen; Fiscal Year: 2007..abstract_text> ..
- UCLA GRADUATE TRAINING PROGRAM IN TRANSITIONAL INVESTIGAJulio Licinio; Fiscal Year: 2004..abstract_text> ..
- Treatment of Calcium Nephrolithiasis Sodium ThiosulfateJohn Asplin; Fiscal Year: 2006..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. [unreadable] [unreadable] [unreadable]..