Genomes and Genes
vitamin b 6
Summary: VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Publications236 found, 100 shown here
- Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritisKathleen Woolf
Arizona State University Department of Nutrition, 6950 E Williams Field Rd, Mesa, AZ 85212, USA
J Am Diet Assoc 108:443-53; discussion 454. 2008..Elevated plasma homocysteine, a risk factor for cardiovascular disease, may help explain why individuals with rheumatoid arthritis have an increased risk of cardiovascular disease...
- Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distributionYoung Min Jang
Department of Biochemistry, Kyungpook National University, Taegu 702 701, Korea
J Biol Chem 278:50040-6. 2003..1 kb was detected in all human tissues examined and was highly abundant in the brain. Obtaining the molecular properties for the human PLP phosphatase may provide new direction for investigating metabolic pathway involving vitamin B6...
- The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiberB Sturtzel
Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austsria
J Nutr Health Aging 14:219-23. 2010..Vitamin B12 deficiency as a digestive disorder and constipation as a gastro motility disorder are common in the elderly. Laxative treatment is often chosen without regard for gut health...
- B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)Loic Le Marchand
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
Cancer Causes Control 13:239-48. 2002....
- Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerShumin M Zhang
Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
J Natl Cancer Inst 95:373-80. 2003..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
- Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidaseJeong Han Kang
Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
Eur J Biochem 271:2452-61. 2004..Our results showed that deletion of the N-terminal 56 residues affects neither the binding of coenzyme nor catalytic activity...
- Vitamin B6 is associated with depressive symptomatology in Massachusetts eldersCRISTINA MERETE
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Am Coll Nutr 27:421-7. 2008....
- Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health StudyJian Shen
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
Am J Clin Nutr 91:337-42. 2010..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved...
- Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thalianaAntoine Danon
Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092 Zurich, Switzerland
Plant J 41:68-80. 2005....
- Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancerEva S Schernhammer
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Gut 59:794-9. 2010..Long interspersed nucleotide element-1 (LINE-1) is an emerging indicator of genome-wide DNA methylation level that has previously been linked to colon cancer survival...
- Two independent routes of de novo vitamin B6 biosynthesis: not that different after allTeresa B Fitzpatrick
ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
Biochem J 407:1-13. 2007..Surprisingly, this comparison reveals that the key biosynthetic enzymes of both pathways are, in fact, very similar both structurally and mechanistically...
- Vitamin B6 status, deficiency and its consequences--an overviewA Spinneker
Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain
Nutr Hosp 22:7-24. 2007..Nowadays, clinically evident vitamin B6 deficiency is not a common disorder, at least in the general population. Nevertheless, a subclinical, undiagnosed deficiency may be present in some subjects, particularly in the elderly...
- Vitamin B6 intakes and status of mechanically ventilated critically ill patients in TaiwanY C Huang
School of Nutrition, Chung Shan Medical University, Taiwan, Republic of China
Eur J Clin Nutr 56:387-92. 2002..To assess vitamin B6 intake and status of critically ill patients. The relationship between vitamin B6 status indicators and the severity of illness and outcome in these patients was also examined...
- The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplastyAndrew Gray
Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
Clin Nutr 23:1080-3. 2004..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
- Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory responseDinesh Talwar
Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, United Kingdom
Clin Chem 49:515-8. 2003
- Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trialChristine M Albert
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
JAMA 299:2027-36. 2008..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
- Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically illYi Chia Huang
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, Republic of China
Nutrition 21:779-85. 2005..This study assessed the effect of vitamin B6 status on immune responses in mechanically ventilated, critically ill patients and compared the results with those of healthy controls...
- Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control studyAnita C Peeters
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Vasc Surg 45:701-5. 2007....
- Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactantsSimone Saibeni
Gastroenterology and Gastrointestinal Endoscopy Service, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
Am J Gastroenterol 98:112-7. 2003..The aim of this study was to evaluate vitamin B(6) plasma levels in IBD patients...
- Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adultsXingwang Ye
Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
J Am Diet Assoc 110:1660-8. 2010..Vitamin B-6 is an important cofactor in many metabolic processes. However, vitamin B-6 intake and plasma status have not been well studied in the Puerto Rican population, a group with documented health disparities...
- Quantification of vitamin B6 vitamers in human cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometryM Van der Ham
Department of Metabolic Diseases and Netherlands Metabolomics Center, University Medical Center UMC Utrecht, Utrecht, The Netherlands
Anal Chim Acta 712:108-14. 2012..The method was applied to CSF samples of 20 subjects and two patients on pyridoxine supplementation. Using minimal CSF volumes this method is suitable for implementation in a routine diagnostic setting...
- Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cellsNoriyuki Yanaka
Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
Mol Nutr Food Res 55:635-43. 2011..Previous reports in the areas of animal studies and, recently epidemiology, have linked anti-tumorigenic and anti-inflammatory effects to dietary vitamin B6. This study investigated the molecular mechanism of these effects of vitamin B6...
- Low intake of vitamin B6 is associated with irritable bowel syndrome symptomsSolveig C Ligaarden
Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway
Nutr Res 31:356-61. 2011..583; β = -4.431; 95% confidence interval, -6.386 to -2.476; P = 0.0002). A significant inverse association between intake of vitamin B₆ and severity of IBS symptoms might have clinical implications...
- Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trialGustavo Saposnik
Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 40:1365-72. 2009..Our aim was to determine whether vitamin therapy reduces the risk of ischemic and hemorrhagic stroke, as well as stroke-related disability...
- ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitaminsKarsten Sydow
Department of Cardiology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
Cardiovasc Res 57:244-52. 2003..We investigated whether oral treatment with B vitamins or L-arginine normalizes endothelium-dependent, flow-dependent vasodilation (FDD) in patients with peripheral arterial occlusive disease (PAOD) and hyperhomocyst(e)inemia...
- A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinomaTodd M Gibson
Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
Cancer Causes Control 21:1061-9. 2010..We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50-69 at baseline...
- 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthaseJeremiah W Hanes
Department of Chemistry and Chemical Biology, Cornell University, 120 Baker Laboratory, Ithaca, New York 14853, USA
Nat Chem Biol 4:425-30. 2008..This analysis revealed a new 1,5 migration of the lysine amine linking the intermediate to the enzyme during the conversion of ribose 5-phosphate to pyridoxal 5'-phosphate...
- Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritisEn Pei I Chiang
Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
Am J Med 114:283-7. 2003..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
- Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediateThomas Raschle
Institute of Plant Sciences, ETH Zurich, 8092 Zurich
J Biol Chem 282:6098-105. 2007..Two alternative structures are proposed for the chromophoric intermediate, both of which require substantial modifications of the proposed mechanism...
- Antitumor effect of vitamin B6 and its mechanismsS Komatsu
Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima 739 8528, Japan
Biochim Biophys Acta 1647:127-30. 2003..The results suggest that dietary vitamin B(6) suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis...
- Folate therapy and in-stent restenosis after coronary stentingHelmut Lange
Kardiologische Praxis, Klinikum Links der Weser, Heart Center, Bremen, Germany
N Engl J Med 350:2673-81. 2004..We tested the effect of a combination of folic acid, vitamin B6, and vitamin B12 (referred to as folate therapy) on the risk of angiographic restenosis after coronary-stent placement in a double-blind, multicenter trial...
- Vitamin B6 biosynthesis in higher plantsMarina Tambasco-Studart
Institute of Plant Sciences, Swiss Federal Institute of Technology ETH, Universitatstrasse 2, CH 8092 Zurich, Switzerland
Proc Natl Acad Sci U S A 102:13687-92. 2005..Furthermore, and contrary to what was inferred previously, we show that the pathway appears to be cytosolic and is not localized to the plastid. Last, we report that the single PDX2 homolog is essential for plant viability...
- PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in ArabidopsisOlca Titiz
ETH Zurich, Institute of Plant Science, 8092 Zurich, Switzerland
Plant J 48:933-46. 2006..Furthermore, we provide evidence that in addition to being essential for plant growth and development, vitamin B6 also plays a role in stress tolerance and photoprotection of plants...
- Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cellsCheryll Perry
Cornell University, Division of Nutritional Science, Ithaca, NY 14853, USA
Arch Biochem Biophys 462:21-7. 2007..Collectively, these data indicate that vitamin B(6) restriction decreases the activity and stability of SHMT, and that the cytoplasmic isozyme is more sensitive to vitamin B(6) deficiency than the mitochondrial isozyme in MCF-7 cells...
- Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathwayEugenia González
Department of Plant Biology, North Carolina State University, Raleigh, North Carolina 27695 7612, USA
Plant Physiol 145:985-96. 2007..Increased expression of salvage and some of the de novo pathway genes was observed in both the pdx3 and sos4 mutants. In all mutants, increased expression was more dramatic for the salvage pathway genes...
- Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 statusEn Pei I Chiang
Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 133:1056-9. 2003..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
- The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo bilobaJan E Leuendorf
Angewandte Genetik, Freie Universitat, Berlin, Germany
FEBS J 275:960-9. 2008..Overall, this study provides a first description of Ginkgo vitamin B6 metabolism, and demonstrates a high degree of conservation between Ginkgo and Arabidopsis...
- Cancer incidence and mortality after treatment with folic acid and vitamin B12Marta Ebbing
Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
JAMA 302:2119-26. 2009..Recently, concern has been raised about the safety of folic acid, particularly in relation to cancer risk...
- Homocysteine lowering with folic acid and B vitamins in vascular diseaseEva Lonn
Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
N Engl J Med 354:1567-77. 2006..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
- The many facets of hyperhomocysteinemia: studies from the Framingham cohortsJacob Selhub
Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 136:1726S-1730S. 2006..Whether this denominator is homocysteine itself or whether homocysteine is merely a marker remains to be determined...
- High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging StudyKatherine L Tucker
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 82:627-35. 2005..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
- Homocysteine lowering and cardiovascular events after acute myocardial infarctionKaare Harald Bønaa
Institute of Community Medicine, University of Tromsø, Tromsø, Norway
N Engl J Med 354:1578-88. 2006..Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction...
- B vitamin status and inflammatory markersAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Atherosclerosis 169:169-74. 2003..In ostensibly healthy adults, B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules, or thrombogenic factors...
- Inflammation causes tissue-specific depletion of vitamin B6En Pei Chiang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
Arthritis Res Ther 7:R1254-62. 2005..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
- Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementationJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas...
- Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzymeRosa A Vacca
Institute of Biomembranes and Bioenergetics, CNR, Via Amendola 165 A, I 70126 Bari, Italy
BMC Biochem 9:17. 2008..Here we report on an attempt to re-enact the emergence of a PLP-dependent protoenzyme. The starting protein was pancreatic ribonuclease A (RNase), in which active-site Lys41 or Lys7 readily form a covalent adduct with PLP...
- Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancerStefan de Vogel
Department of Epidemiology, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
Carcinogenesis 29:1765-73. 2008....
- Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trialAndrew H Ford
South Metropolitan Health Service, Perth, Australia
J Clin Psychiatry 69:1203-9. 2008..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression...
- Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generatorR Chumnantana
Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
Biochim Biophys Acta 1722:84-91. 2005..The antioxidant function of pyridoxal 5'-phosphate was not dependent on the phosphorelay pathway, which finally triggers the expression of the catalase gene...
- Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican womenMartin Lajous
Instituto Nacional de Salud Publica, Av Universidad 655, Col Santa Maria Ahuacatitlan, Cuernavaca, Morelos 62508, Mexico
Cancer Epidemiol Biomarkers Prev 15:443-8. 2006..We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes...
- The short-rooted vitamin B6-deficient mutant pdx1 has impaired local auxin biosynthesisHao Chen
Donald Danforth Plant Science Center, St Louis, MO 63132, USA
Planta 229:1303-10. 2009..These data indicate that pdx1 is impaired in Trp-dependent auxin biosynthesis, which may contribute to the short-root phenotype of pdx1. We suggest that locally synthesized auxin may play a critical role in postembryonic root growth...
- Vitamin B6 suppresses apoptosis of NM-1 bovine endothelial cells induced by homocysteine and copperNaoko Endo
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
Biochim Biophys Acta 1770:571-7. 2007..These results suggest that pyridoxal treatment suppresses apoptosis of NM-1 cells induced by homocysteine and copper, most likely through antioxidant effects...
- Effect of high-glucose levels on protein oxidation in cultured lens cells, and in crystalline and albumin solution and its inhibition by vitamin B6 and N-acetylcysteine: its possible relevance to cataract formation in diabetesAman K Jain
Caddo Magnet High School, Shreveport, LA 71130, USA
Free Radic Biol Med 33:1615-21. 2002..This study explains the cause of early cataract development and the potential benefit of supplementation with vitamin B6 and NAC in the prevention of the development of cataract among the diabetic population...
- [An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children]Rafael Garcia-Lopez
Departamento de Anestesia y Reanimación Hospital Costa del Sol Marbella Málaga España
Med Clin (Barc) 131:689-91. 2008..We also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group...
- The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participantsShari S Bassuk
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Womens Health (Larchmt) 13:99-117. 2004..Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women...
- Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementationSandra Hirsch
Institute of Nutrition and Food Technology, University of Chile, Santiago
Clin Cardiol 25:495-501. 2002..The relationship between hyperhomocysteinemia and cardiovascular disease has not been totally elucidated...
- Biochemistry of homocysteine in health and diseasesS Ramakrishnan
Biochemistry Research Department, Vision Research Foundation, Sankara Nethralaya, Chennai 600 006, India
Indian J Biochem Biophys 43:275-83. 2006....
- Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemiaMustafa Hakan Dinckal
Department of Cardiology, Medical Faculty of Gaziantep University, Gaziantep, Turkey
Acta Cardiol 58:389-96. 2003..This study was performed to determine the effect of homocysteine-lowering therapy (HLT) on endothelium-dependent vasodilation (EDD) and exercise performance in patients with coronary artery disease...
- Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytesKrishnaswamy Kannan
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
Free Radic Biol Med 36:423-8. 2004..B6 compounds can prevent the oxygen radical generation and lipid peroxidation caused by hydrogen peroxide in U937 monocytes, and that some of the protective effect of Vit.B6 may occur via modification of mitochondrial function...
- Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitusKaren E MacKenzie
Department of Diabetes and Endocrinology, Children, Youth, and Women s Health Service, Adelaide, Australia
Pediatrics 118:242-53. 2006..Endothelial dysfunction, a precursor of vascular disease, begins early in type 1 diabetes mellitus and is associated with folate status...
- Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trialJames F Toole
Stroke Research Center, Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 291:565-75. 2004..However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials...
- Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesisSusan Wagner
Angewandte Genetik, Freie Universitat Berlin, 14195 Berlin, Germany
Plant Cell 18:1722-35. 2006..In summary, our results demonstrate the critical function of the PDX1 protein family for metabolism, whole-plant development, and vitamin B6 biosynthesis in higher plants...
- On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilisThomas Raschle
ETH Zurich, Institut für Pflanzenwissenschaften, Zurich, Switzerland
J Biol Chem 280:32291-300. 2005..The results are discussed in light of the nature of the interaction of the two components of the enzyme complex...
- Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6Susana Rodriguez-Navarro
Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, C Dr Moliner 50, E 46100, Burjassot, Spain
Yeast 19:1261-76. 2002..Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase...
- Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal womenEunyoung Cho
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:2787-90. 2007..In conclusion, we found no evidence that higher intakes of nutrients involved in one-carbon metabolism reduce risk of breast cancer among premenopausal women...
- Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese menJunko Ishihara
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
J Nutr 137:1808-14. 2007..Our results support previous evidence that low vitamin B-6 intake is associated with an increased risk of colorectal cancer. In particular, a higher intake of vitamin B-6 appears beneficial in men with higher alcohol intake...
- Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in womenJennifer Lin
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 87:734-43. 2008..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
- The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditionsB L Grimaldi
Med Hypotheses 58:47-60. 2002....
- Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12Uwe Till
Institute of Pathobiochemistry, Friedrich Schiller University, Postfach, Jena, Germany
Atherosclerosis 181:131-5. 2005..Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce...
- Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trialGuido Schnyder
Division of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Switzerland
JAMA 288:973-9. 2002....
- Vitamin B6: a long known compound of surprising complexitySutton Mooney
School of Biological Sciences, Washington State University, Pullman, WA, USA
Molecules 14:329-51. 2009....
- Serum total homocysteine levels, folate, and B-vitamins intake and coronary heart disease risk factors among tri-ethnic college studentsSamer Koutoubi
Nutrition Department, Bastyr University, Kenmore, Washington 98028, USA
Ethn Dis 14:64-72. 2004..009), and Black non-Hispanic females (P=.005). We observed gender and ethnic differences in tHcy levels of this young population with normal tHcy levels. Abnormally high tHcy concentrations appear to be acquired later in life...
- [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]Alba Rosa Morón de Salim
Departamento de Bioquimica, Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Estado Carabobo, Venezuela
Arch Latinoam Nutr 55:28-33. 2005..of vitamins B12, B6 and folic acid, may is effective in decreased plasmatic homocysteine levels and lipids, mainly triglycerides, with a reduction of coronary risk, to these type of patients, with not collateral effects of neuropathy..
- Plasma homocysteine levels and vitamin B status in patients with Pseudoexfoliation syndromeM Sinan Saricaoglu
Third Eye Clinic, Ankara Numune Training ana Research Hospital, Sihhiye, Ankara, Turkey
Saudi Med J 27:833-7. 2006....
- Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementationPal I Holm
LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
Arterioscler Thromb Vasc Biol 24:301-7. 2004..Betaine is a substrate in the betaine-homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine (tHcy) concentration...
- Total homocysteine, diet, and lipid profiles in type 1 and type 2 diabetic and nondiabetic adolescentsMelissa Spezia Faulkner
College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA
J Cardiovasc Nurs 21:47-55. 2006....
- Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adultsCynthia M Carlsson
Section of Cardiovascular Medicine, University of Wisconsin Medical School, and the Veterans Affairs Geriatrics Research, Education, and Clinical Center GRECC, Madison, Wis 53705, USA
Am Heart J 148:E11. 2004..The objective of this study was to determine the effects of multivitamins (MV) and folic acid (FA) supplements on flow-mediated vasodilation (FMD) in older adults...
- Eat right and exercise for lower homocysteine levels and less chance of heart diseaseSamer Koutoubi
Ethn Dis 14:160. 2004
- Water-soluble vitamins: research updateEugene J Bruno
Huntington College of Health Sciences, 1101 S Milliken, Ste A, Ontario, CA 91761, USA
Curr Sports Med Rep 4:207-13. 2005....
- [Efficacy and safety of two vitamin supplement regimens on homocysteine levels in hemodialysis patients. Prospective, randomized clinical trial]J E Sánchez Alvarez
Hospital Tamaragua, Tenerife
Nefrologia 25:288-96. 2005..Moreover, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism can modulate its prevalence and response to treatment...
- Do low doses of folic acid result in maximum lowering of homocysteine?Lynn B Bailey
Am J Clin Nutr 82:717-8. 2005
- Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 yearsMaike Wolters
Nutrition Physiology and Human Nutrition Unit, Institute of Food Science Centre of Applied Chemistry University of Hanover, Wunstorfer Str 14, 30453, Hannover, Germany
Eur J Nutr 44:183-92. 2005..Studies have shown that supplementation of the three vitamins can lower tHcy even in subjects with tHcy in the normal range...
- [Group B vitamins as new variables related to the cardiovascular risk]Monica Granieri
Istituto di Cardiologia, Universita degli Studi G D Annunzio, Chieti
Ital Heart J Suppl 6:1-16. 2005..A further confirmation of these data is important to devise future intervention strategies in primary and secondary prophylaxis of atherosclerotic vascular disease...
- Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trialRajesh Ullegaddi
Sheffield Institute for Nutritional Studies on Ageing and the Human Nutrition Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK
JPEN J Parenter Enteral Nutr 30:108-14. 2006..Several studies point to an antioxidant effect of B-group vitamins and a pro-oxidant effect of elevated total plasma homocysteine (tHcy)...
- Plasma homocysteine levels and risk of Alzheimer diseaseJ A Luchsinger
Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, USA
Neurology 62:1972-6. 2004..To explore the association between high homocysteine levels and risk of Alzheimer disease (AD) in the Washington Heights-Inwood Columbia Aging Project (WHICAP)...
- Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trialE Lonn
Hamilton Health Sciences Corporation, Hamilton, Ontario
Can J Cardiol 22:47-53. 2006..Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events...
- Association of B vitamins status and homocysteine levels in elderly TaiwaneseKuan Ju Chen
Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan
Asia Pac J Clin Nutr 14:250-5. 2005....
- Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular diseaseDavid J Stott
Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
Am J Clin Nutr 82:1320-6. 2005..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
- [Homocysteine and neuropsychiatric disorders]Perminder Sachdev
Faculdade de Psiquiatria, Universidade de New South Wales, Sydney, Australia
Rev Bras Psiquiatr 26:50-6. 2004..More research evidence is necessary before population screening can be recommended...
- Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patientsGrace Y H Ho
Department of Neurology, Singapore General Hospital, Singapore
Stroke 37:456-60. 2006....
- Vitamins and minerals 4: overview of folate and the B vitaminsJune Thompson
Community Pract 79:197-8. 2006..In the fourth of an occasional series on vitamins, minerals and supplements, June Thompson looks at the role folate, in particular, may play in reducing homocysteine in the body and in protecting the body from some other diseases...
- DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendationsOlaf Stanger
Landesklinik für Herzchirurgie, Landeskliniken Salzburg, Salzburg, Austria
Clin Chem Lab Med 41:1392-403. 2003..The results of ongoing randomized controlled intervention trials must be available before screening for, and treatment of, hyperhomocysteinemia can be recommended for the apparently healthy general population...
- [Risk factors for cardiovascular diseases: what is the role for homocysteine?]Maria Grazia Bendini
U O di Cardiologia, Ospedale S Maria della Stella, Orvieto, TR
G Ital Cardiol (Rome) 8:148-60. 2007....
- [Nutritional medicine 2007]H Hauner
Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Munchen, Germany
Dtsch Med Wochenschr 132:1411-3. 2007
- Public health significance of elevated homocysteineJacob Selhub
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Food Nutr Bull 29:S116-25. 2008..Whether this denominator is homocysteine itself or homocysteine is merely a marker, remains to be determined...
- Emergent cardiovascular risk factor: homocysteineCindy J Warren
College of Nursing, Kent State University, Tuscarawas Campus, New Philadelphia, OH 44663, USA
Prog Cardiovasc Nurs 17:35-41. 2002..Risk factors for elevated homocysteine and intervention with B vitamins are discussed. Cardiovascular nurses are encouraged to facilitate homocysteine awareness through a variety of educational means...
- Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivoresChien Jung Hung
Department of Biochemistry, College of Medicine, Tzu Chi University, Hualien, Taiwan
J Nutr 132:152-8. 2002..7% of homocysteine variation. In conclusion, the Buddhist nuns who consumed a lacto-vegetarian diet had mildly elevated fasting plasma homocysteine levels presumably due to lower levels of plasma vitamin B-12...
- Homocysteine lowering and cardiovascular disease risk: lost in translationJeremy Marcus
Department of Medicine, Division of Nephrology, Tufts New England Medical Centre, Boston, Massachusetts 02111, USA
Can J Cardiol 23:707-10. 2007..Several more interventional trials are ongoing, but the available data thus far do not support screening for or treatment of hyperhomocysteinemia...
- Association of plasma homocysteine and macular edema in type 2 diabetes mellitusE Aydin
Department of Ophthalmology, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey
Eur J Ophthalmol 18:226-32. 2008..The aim of this study was to assess the association of macular edema (ME) with plasma homocysteine, vitamin B6, vitamin B12, and folic acid levels in patients with Type 2 diabetes...
- [Plasma homocysteine levels in patients with ischemic heart disease]L Mark
Békés Megyei Képviselotestület Pándy Kálmán Kórháza, Gyula, II Belgyógyászat Kardiológia
Orv Hetil 142:1611-5. 2001..436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354)...
- [Homocysteine--a risk factor for atherosclerosis]L Debreceni
Orv Hetil 142:1439-44. 2001....
- Folic Acid and B Vitamins to Prevent Fracture in WomenSteven Cummings; Fiscal Year: 2009..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
- Vitamin B6 Effects on One-Carbon MetabolismJesse F Gregory; Fiscal Year: 2010..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy in OC users and will provide a metabolically validated supplementation strategy to alleviate low B6 status and promote health in OC users. ..
- Folic Acid and B Vitamins to Prevent Fracture in WomenSteven Cummings; Fiscal Year: 2007..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
- THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIAJoseph Eustace; Fiscal Year: 2004..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
- Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortJoel Schwartz; Fiscal Year: 2007..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
- Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortJoel Schwartz; Fiscal Year: 2009..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
- Molecular Pathogenesis and Treatment of HypophosphatasiaJose Luis Millan; Fiscal Year: 2009..In addition, we have uncovered novel activators of alkaline phosphatase function that can be developed into pharmaceuticals to increase bone mineral density in patients with hypophosphatasia and osteoporosis. ..
- GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINEWarren Kruger; Fiscal Year: 2007..Cystathionine beta-synthase (CBS) is a key enzyme in the metabolism of homocysteine. In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. ..
- GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINEWarren Kruger; Fiscal Year: 2009..Cystathionine beta-synthase (CBS) is a key enzyme in the metabolism of homocysteine. In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. ..
- VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGETerry Shultz; Fiscal Year: 2002....
- A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and InflammationCornelia M Ulrich; Fiscal Year: 2010..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
- A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and InflammationCornelia Ulrich; Fiscal Year: 2009..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
- ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFERPERRY FREY; Fiscal Year: 2002..If the beta-aminoacyl substituents function in this way, they could become significant in drug delivery strategies, especially for candidate drugs that are minimally soluble. ..
- Vitamin B6 Effects on One-Carbon MetabolismJESSE GREGORY; Fiscal Year: 2007..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy and will yield new information regarding nutritional dependence of human 1C metabolism. ..
- Molecular Pathogenesis and Treatment of HypophosphatasiaJose Luis Millan; Fiscal Year: 2010..In addition, we have uncovered novel activators of alkaline phosphatase function that can be developed into pharmaceuticals to increase bone mineral density in patients with hypophosphatasia and osteoporosis. ..
- B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAILHOWARD HODIS; Fiscal Year: 2004..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
- Long-Term Dietary Risk Factor Assessment and Incident ADMARTHA MORRIS; Fiscal Year: 2007..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
- Long-Term Dietary Risk Factor Assessment and Incident ADMARTHA MORRIS; Fiscal Year: 2009..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
- NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCERJing Ma; Fiscal Year: 2007..Hence, the proposed project is highly cost-efficient. ..
- REACTION SPECIFICITY OF PYRIDOXAL PHOSPHATE ENZYMESMICHAEL TONEY; Fiscal Year: 2010..Our studies will provide the fundamental knowledge required to target these enzymes highly specifically with small molecule drugs. ..
- Diet, DNA Repair Genes and Breast Cancer RiskARCHANA MCELIGOT; Fiscal Year: 2007..Additionally, the findings of this study will provide directions for future epigenetic investigations, and targeted cancer prevention strategies. ..
- RELATION OF DIET TO SERUM HOMOCYSTEINE LEVEL IN YOUTHSStavroula Osganian; Fiscal Year: 2001..African Americans vs. Hispanics. Information generated by this study will be valuable for designing specific dietary interventions for youth and targeting subgroups of children who may be at higher risk for CVD. ..
- BIOSYNTHESIS OF MICROBIAL NATURAL PRODUCTSDAVID CANE; Fiscal Year: 1993..The PCR products will be inserted into suitable E. coli expression vectors and the resulting overexpressed proteins will be used by Prof. Spenser and his collaborators to examine the formation of pyridoxol...
- Effect of Pyridoxamine in Oxalate excretion in Stone Disease and HyperoxaluriaJon Scheinman; Fiscal Year: 2007..The public health implications of this study are in its contributions to preventing common kidney stone disease, and preventing kidney failure in an orphan disease, Primary Hyperoxaluria. ..