vitamin b 6

Summary

Summary: VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.

Top Publications

  1. ncbi Cancer incidence and mortality after treatment with folic acid and vitamin B12
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
    JAMA 302:2119-26. 2009
  2. pmc Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
  3. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
  4. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
  5. ncbi Regulation of the Arabidopsis thaliana vitamin B6 biosynthesis genes by abiotic stress
    Sheri A Denslow
    Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695 7616, USA
    Plant Physiol Biochem 45:152-61. 2007
  6. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
  7. ncbi Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a Western Norway B Vitamin Intervention Trial (WENBIT) substudy
    Kjetil H Løland
    Institute of Medicine, University of Bergen, Bergen, Norway
    Am J Cardiol 105:1577-84. 2010
  8. ncbi Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:1446-54. 2008
  9. ncbi Vitamin B6: a molecule for human health?
    Hanjo Hellmann
    Washington State University, Abelson 435, P O Box 66224, Pullman, WA, USA
    Molecules 15:442-59. 2010
  10. ncbi Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry
    Øivind Midttun
    Bevital A S, Armauer Hansens Hus, N 5021 Bergen, Norway
    Rapid Commun Mass Spectrom 23:1371-9. 2009

Research Grants

  1. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
  2. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
  4. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
  5. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
  6. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
  7. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
  8. Molecular Pathogenesis and Treatment of Hypophosphatasia
    Jose Luis Millan; Fiscal Year: 2013
  9. Chemically-Rich Structure and Dynamics in the Active Site of Tryptophan Synthase
    Leonard J Mueller; Fiscal Year: 2013
  10. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010

Detail Information

Publications268 found, 100 shown here

  1. ncbi Cancer incidence and mortality after treatment with folic acid and vitamin B12
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
    JAMA 302:2119-26. 2009
    ..Recently, concern has been raised about the safety of folic acid, particularly in relation to cancer risk...
  2. pmc Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
    ..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved...
  3. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
    ..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
  4. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  5. ncbi Regulation of the Arabidopsis thaliana vitamin B6 biosynthesis genes by abiotic stress
    Sheri A Denslow
    Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695 7616, USA
    Plant Physiol Biochem 45:152-61. 2007
    ..Insight into regulation of the biosynthetic genes during abiotic stress could have important applications in the development of stress-tolerant crops...
  6. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  7. ncbi Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a Western Norway B Vitamin Intervention Trial (WENBIT) substudy
    Kjetil H Løland
    Institute of Medicine, University of Bergen, Bergen, Norway
    Am J Cardiol 105:1577-84. 2010
    ..In conclusion, vitamin B treatment showed no beneficial effect on the angiographic progression of coronary artery disease, and the post hoc analyses suggested that folic acid/vitamin B(12) treatment might promote more rapid progression...
  8. ncbi Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004
    Martha Savaria Morris
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:1446-54. 2008
    ....
  9. ncbi Vitamin B6: a molecule for human health?
    Hanjo Hellmann
    Washington State University, Abelson 435, P O Box 66224, Pullman, WA, USA
    Molecules 15:442-59. 2010
    ..Finally, because in recent years the vitamin has often been considered beneficial for human health, the review will also sum up and critically reflect on current knowledge how human health can profit from vitamin B6...
  10. ncbi Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry
    Øivind Midttun
    Bevital A S, Armauer Hansens Hus, N 5021 Bergen, Norway
    Rapid Commun Mass Spectrom 23:1371-9. 2009
    ..05 to 7 nmol/L. The method enables quantification of endogenous plasma concentrations of 16 analytes related to B-vitamin status and inflammation, and may prove useful in large-scale epidemiological studies...
  11. ncbi Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials
    M Ebbing
    Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
    J Intern Med 268:367-82. 2010
    ....
  12. ncbi Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution
    Young Min Jang
    Department of Biochemistry, Kyungpook National University, Taegu 702 701, Korea
    J Biol Chem 278:50040-6. 2003
    ..1 kb was detected in all human tissues examined and was highly abundant in the brain. Obtaining the molecular properties for the human PLP phosphatase may provide new direction for investigating metabolic pathway involving vitamin B6...
  13. ncbi Serum B vitamin levels and risk of lung cancer
    Mattias Johansson
    International Agency for Research on Cancer, Lyon, France
    JAMA 303:2377-85. 2010
    ..B vitamins and factors related to 1-carbon metabolism help to maintain DNA integrity and regulate gene expression and may affect cancer risk...
  14. ncbi Homocysteine lowering with folic acid and B vitamins in vascular disease
    Eva Lonn
    Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
    N Engl J Med 354:1567-77. 2006
    ..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
  15. ncbi Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis
    Thomas Dick
    Novartis Institute for Tropical Diseases Pte Ltd, 10 Biopolis Road, 05 01 Chromos, Singapore 138670, Singapore
    Mol Microbiol 78:980-8. 2010
    ..We conclude that vitamin B6 biosynthesis is required for survival of M. tuberculosis in vivo and thus might represent a candidate pathway for the development of new antitubercular agents...
  16. pmc Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:794-9. 2010
    ..Long interspersed nucleotide element-1 (LINE-1) is an emerging indicator of genome-wide DNA methylation level that has previously been linked to colon cancer survival...
  17. ncbi Two independent routes of de novo vitamin B6 biosynthesis: not that different after all
    Teresa B Fitzpatrick
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Biochem J 407:1-13. 2007
    ..Surprisingly, this comparison reveals that the key biosynthetic enzymes of both pathways are, in fact, very similar both structurally and mechanistically...
  18. pmc Vitamin B6 biosynthesis in higher plants
    Marina Tambasco-Studart
    Institute of Plant Sciences, Swiss Federal Institute of Technology ETH, Universitatstrasse 2, CH 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:13687-92. 2005
    ..Furthermore, and contrary to what was inferred previously, we show that the pathway appears to be cytosolic and is not localized to the plastid. Last, we report that the single PDX2 homolog is essential for plant viability...
  19. pmc Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial
    Shumin M Zhang
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 300:2012-21. 2008
    ..Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention...
  20. pmc Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status
    Martha Savaria Morris
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 140:103-10. 2010
    ....
  21. ncbi Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus
    Karen E MacKenzie
    Department of Diabetes and Endocrinology, Children, Youth, and Women s Health Service, Adelaide, Australia
    Pediatrics 118:242-53. 2006
    ..Endothelial dysfunction, a precursor of vascular disease, begins early in type 1 diabetes mellitus and is associated with folate status...
  22. ncbi Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study
    Anita C Peeters
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Vasc Surg 45:701-5. 2007
    ....
  23. pmc Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women
    Shumin M Zhang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 163:108-15. 2006
    ..An alternative explanation is that other factors related to dietary intakes of folate and vitamin B(6) account for the inverse associations...
  24. ncbi Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response
    Dinesh Talwar
    Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Clin Chem 49:515-8. 2003
  25. ncbi Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 67:5553-60. 2007
    ..Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk...
  26. ncbi The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty
    Andrew Gray
    Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 23:1080-3. 2004
    ..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
  27. ncbi Dietary vitamin B6 intake and the risk of colorectal cancer
    Evropi Theodoratou
    Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:171-82. 2008
    ..Evidence from larger cohort and experimental studies is now required to confirm and define the anticarcinogenic actions of vitamin B6 and to explore the mechanisms by which this effect is mediated...
  28. ncbi Folate therapy and in-stent restenosis after coronary stenting
    Helmut Lange
    Kardiologische Praxis, Klinikum Links der Weser, Heart Center, Bremen, Germany
    N Engl J Med 350:2673-81. 2004
    ..We tested the effect of a combination of folic acid, vitamin B6, and vitamin B12 (referred to as folate therapy) on the risk of angiographic restenosis after coronary-stent placement in a double-blind, multicenter trial...
  29. ncbi Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users
    Federico Lussana
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, Italy
    Thromb Res 112:37-41. 2003
    ..To compare the levels of total homocysteine (tHcy), folate, vitamin B6 and B12, in women not using oral contraceptives (OC) vs. those using OC...
  30. pmc Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    BMC Cancer 9:122. 2009
    ..However, the association between B vitamin intake and breast cancer risk in Brazilian women in particular has not yet been investigated...
  31. ncbi Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation
    Oivind Midttun
    Bevital A S, Laboratoriebygget, 5021 Bergen, Norway
    J Nutr 141:611-7. 2011
    ..Thus, low plasma PLP during inflammation may reflect impaired cellular vitamin B-6 status, as indicated by the concurrent increase in plasma HK...
  32. ncbi The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber
    B Sturtzel
    Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austsria
    J Nutr Health Aging 14:219-23. 2010
    ..Vitamin B12 deficiency as a digestive disorder and constipation as a gastro motility disorder are common in the elderly. Laxative treatment is often chosen without regard for gut health...
  33. pmc Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
    Burak Turgut
    Firat University School of Medicine, Department of Ophthalmology, Elazig, Turkey
    Clin Interv Aging 5:133-9. 2010
    ....
  34. ncbi Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase
    Jeong Han Kang
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Eur J Biochem 271:2452-61. 2004
    ..Our results showed that deletion of the N-terminal 56 residues affects neither the binding of coenzyme nor catalytic activity...
  35. ncbi Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women
    Martin Lajous
    Instituto Nacional de Salud Publica, Av Universidad 655, Col Santa Maria Ahuacatitlan, Cuernavaca, Morelos 62508, Mexico
    Cancer Epidemiol Biomarkers Prev 15:443-8. 2006
    ..We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes...
  36. ncbi Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery
    William Dickey
    Department of Gastroenterology, Altnagelvin Hospital, Londonderry, Northern Ireland, UK
    Scand J Gastroenterol 43:682-8. 2008
    ..The objective of this study was to compare plasma homocysteine levels and biomarker status of metabolically related B vitamins (folate, vitamin B(12), B(6) and riboflavin) in treated and untreated CD patients and healthy controls...
  37. ncbi On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis
    Thomas Raschle
    ETH Zurich, Institut für Pflanzenwissenschaften, Zurich, Switzerland
    J Biol Chem 280:32291-300. 2005
    ..The results are discussed in light of the nature of the interaction of the two components of the enzyme complex...
  38. ncbi Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana
    Antoine Danon
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092 Zurich, Switzerland
    Plant J 41:68-80. 2005
    ....
  39. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ....
  40. ncbi Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:1056-9. 2003
    ..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
  41. ncbi Folate, vitamin B12 and vitamin B6 and one carbon metabolism
    J Selhub
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr Health Aging 6:39-42. 2002
    ..We need more studies to confirm that these vitamins have important functions in the etiology of these diseases. We also need to establish if these diseases can be prevented or diminished by proper nutrition starting at a younger age...
  42. ncbi Vitamin B6 status, deficiency and its consequences--an overview
    A Spinneker
    Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain
    Nutr Hosp 22:7-24. 2007
    ..Nowadays, clinically evident vitamin B6 deficiency is not a common disorder, at least in the general population. Nevertheless, a subclinical, undiagnosed deficiency may be present in some subjects, particularly in the elderly...
  43. pmc Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women
    Yvonne Lamers
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, College of Medicine, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 141:835-42. 2011
    ..Interrelationships among plasma concentrations of glycine and cystathionine and kinetic results suggest that individual variability occurs in normal postprandial 1-carbon metabolism and in the response to vitamin B-6 restriction...
  44. ncbi Re: Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Katharina Schroecksnadel
    J Natl Cancer Inst 95:1091; author reply 1091. 2003
  45. ncbi Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats
    Jennifer B Scheer
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611, USA
    J Nutr 135:233-8. 2005
    ..05), which suggests a functional effect of altered SHMT activity. Overall these results demonstrate the potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake...
  46. ncbi Vitamin B6: a challenging link between nutrition and inflammation in CVD
    Valentina Lotto
    Department of Medicine, University of Verona School of Medicine, Policlinico GB Rossi, Verona, Italy
    Br J Nutr 106:183-95. 2011
    ..A mild vitamin B6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy...
  47. pmc Vitamin B6 is associated with depressive symptomatology in Massachusetts elders
    CRISTINA MERETE
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 27:421-7. 2008
    ....
  48. ncbi Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme
    Martin K Safo
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23219, USA
    Acta Crystallogr D Biol Crystallogr 61:599-604. 2005
    ....
  49. pmc Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women
    Yu Ching Chou
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    J Epidemiol 21:329-36. 2011
    ..B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis...
  50. ncbi High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 82:627-35. 2005
    ..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
  51. ncbi Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status
    Cai Xia Zhang
    Centre of Research and Promotion of Women s Health, 4th Floor, School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong Special Administrative Region, People s Republic of China
    Br J Nutr 106:936-43. 2011
    ..These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status...
  52. ncbi Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women
    Steven R Davis
    Food Science andHuman Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 136:373-8. 2006
    ..These data indicate that glutathione homeostasis is altered by dietary vitamin B-6 deficiency and appears to be unrelated to cysteine flux under conditions of minimal amino acid intake as evaluated in this study...
  53. pmc Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women
    Mei Zhao
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, niversity of Florida, Gainesville, FL, USA
    J Nutr 142:1791-7. 2012
    ..Such changes in blood lipids may be associated with the elevated risk of cardiovascular disease in vitamin B-6 insufficiency...
  54. ncbi Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men
    Steven R Davis
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville 32611 0370, USA
    Am J Clin Nutr 81:648-55. 2005
    ..The effects of vitamin B-6 status on steady-state kinetics of homocysteine metabolism in humans are unclear...
  55. ncbi Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis
    M Cattaneo
    Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy
    Circulation 104:2442-6. 2001
    ..We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT...
  56. pmc Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women
    Yvonne Lamers
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611, USA
    J Nutr 139:452-60. 2009
    ..We conclude that the in vivo GCS and SHMT reactions are quite resilient to the effects of marginal vitamin B-6 deficiency, presumably through a compensatory effect of increasing substrate concentration...
  57. pmc Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women
    Yvonne Lamers
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Am J Clin Nutr 90:336-43. 2009
    ..Despite this obligatory role of PLP, previous studies from this laboratory showed that vitamin B-6 deficiency caused elevated glutathione concentrations in rat liver and human plasma...
  58. pmc Prediagnostic plasma pyridoxal 5'-phosphate (vitamin b6) levels and invasive breast carcinoma risk: the multiethnic cohort
    Galina Lurie
    University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 21:1942-8. 2012
    ..Evidence from experimental and epidemiologic studies suggests that vitamin B6 may reduce the risk of breast cancer...
  59. ncbi Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects
    Diego Vanuzzo
    Cardiovascular Prevention Center, ASS 4 and Agenzia Regionale della Sanità del Friuli Venezia Giulia, Udine, Italy
    Eur Heart J 28:484-91. 2007
    ..We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study...
  60. ncbi [Homocysteine after a methionine load in healthy subjects with adequate B-vitamin status]
    Mardia López-Alarcón
    Unidad de Investigación Médica en Nutrición, Hospital de Pediatria, Centro Médico Nacional CMN Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Mexico, D F, Mexico
    Cir Cir 79:432-8. 2011
    ..We undertook this study to determine Hcy concentrations from baseline to 24- and 48-h after an OML in non-B-vitamin deficient adult subjects with other risk factors for high levels of Hcy such as smoking and overweight...
  61. ncbi Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan
    Y C Huang
    School of Nutrition, Chung Shan Medical University, Taiwan, Republic of China
    Eur J Clin Nutr 56:387-92. 2002
    ..To assess vitamin B6 intake and status of critically ill patients. The relationship between vitamin B6 status indicators and the severity of illness and outcome in these patients was also examined...
  62. ncbi Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms
    Solveig C Ligaarden
    Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway
    Nutr Res 31:356-61. 2011
    ..583; β = -4.431; 95% confidence interval, -6.386 to -2.476; P = 0.0002). A significant inverse association between intake of vitamin B₆ and severity of IBS symptoms might have clinical implications...
  63. ncbi Quantification of vitamin B6 vitamers in human cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometry
    M Van der Ham
    Department of Metabolic Diseases and Netherlands Metabolomics Center, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Anal Chim Acta 712:108-14. 2012
    ..The method was applied to CSF samples of 20 subjects and two patients on pyridoxine supplementation. Using minimal CSF volumes this method is suitable for implementation in a routine diagnostic setting...
  64. ncbi Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants
    Simone Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Am J Gastroenterol 98:112-7. 2003
    ..The aim of this study was to evaluate vitamin B(6) plasma levels in IBD patients...
  65. ncbi Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells
    Noriyuki Yanaka
    Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    Mol Nutr Food Res 55:635-43. 2011
    ..Previous reports in the areas of animal studies and, recently epidemiology, have linked anti-tumorigenic and anti-inflammatory effects to dietary vitamin B6. This study investigated the molecular mechanism of these effects of vitamin B6...
  66. ncbi Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill
    Yi Chia Huang
    School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Nutrition 21:779-85. 2005
    ..This study assessed the effect of vitamin B6 status on immune responses in mechanically ventilated, critically ill patients and compared the results with those of healthy controls...
  67. pmc Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adults
    Xingwang Ye
    Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
    J Am Diet Assoc 110:1660-8. 2010
    ..Vitamin B-6 is an important cofactor in many metabolic processes. However, vitamin B-6 intake and plasma status have not been well studied in the Puerto Rican population, a group with documented health disparities...
  68. ncbi Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial
    Gustavo Saposnik
    Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 40:1365-72. 2009
    ..Our aim was to determine whether vitamin therapy reduces the risk of ischemic and hemorrhagic stroke, as well as stroke-related disability...
  69. ncbi ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins
    Karsten Sydow
    Department of Cardiology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Cardiovasc Res 57:244-52. 2003
    ..We investigated whether oral treatment with B vitamins or L-arginine normalizes endothelium-dependent, flow-dependent vasodilation (FDD) in patients with peripheral arterial occlusive disease (PAOD) and hyperhomocyst(e)inemia...
  70. pmc A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
    Todd M Gibson
    Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
    Cancer Causes Control 21:1061-9. 2010
    ..We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50-69 at baseline...
  71. ncbi PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis
    Olca Titiz
    ETH Zurich, Institute of Plant Science, 8092 Zurich, Switzerland
    Plant J 48:933-46. 2006
    ..Furthermore, we provide evidence that in addition to being essential for plant growth and development, vitamin B6 also plays a role in stress tolerance and photoprotection of plants...
  72. ncbi Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate
    Thomas Raschle
    Institute of Plant Sciences, ETH Zurich, 8092 Zurich
    J Biol Chem 282:6098-105. 2007
    ..Two alternative structures are proposed for the chromophoric intermediate, both of which require substantial modifications of the proposed mechanism...
  73. ncbi Antitumor effect of vitamin B6 and its mechanisms
    S Komatsu
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima 739 8528, Japan
    Biochim Biophys Acta 1647:127-30. 2003
    ..The results suggest that dietary vitamin B(6) suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis...
  74. ncbi Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Med 114:283-7. 2003
    ..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
  75. ncbi 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase
    Jeremiah W Hanes
    Department of Chemistry and Chemical Biology, Cornell University, 120 Baker Laboratory, Ithaca, New York 14853, USA
    Nat Chem Biol 4:425-30. 2008
    ..This analysis revealed a new 1,5 migration of the lysine amine linking the intermediate to the enzyme during the conversion of ribose 5-phosphate to pyridoxal 5'-phosphate...
  76. ncbi The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo biloba
    Jan E Leuendorf
    Angewandte Genetik, Freie Universitat, Berlin, Germany
    FEBS J 275:960-9. 2008
    ..Overall, this study provides a first description of Ginkgo vitamin B6 metabolism, and demonstrates a high degree of conservation between Ginkgo and Arabidopsis...
  77. pmc Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway
    Eugenia González
    Department of Plant Biology, North Carolina State University, Raleigh, North Carolina 27695 7612, USA
    Plant Physiol 145:985-96. 2007
    ..Increased expression of salvage and some of the de novo pathway genes was observed in both the pdx3 and sos4 mutants. In all mutants, increased expression was more dramatic for the salvage pathway genes...
  78. ncbi The many facets of hyperhomocysteinemia: studies from the Framingham cohorts
    Jacob Selhub
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 136:1726S-1730S. 2006
    ..Whether this denominator is homocysteine itself or whether homocysteine is merely a marker remains to be determined...
  79. pmc Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
    Cheryll Perry
    Cornell University, Division of Nutritional Science, Ithaca, NY 14853, USA
    Arch Biochem Biophys 462:21-7. 2007
    ..Collectively, these data indicate that vitamin B(6) restriction decreases the activity and stability of SHMT, and that the cytoplasmic isozyme is more sensitive to vitamin B(6) deficiency than the mitochondrial isozyme in MCF-7 cells...
  80. ncbi B vitamin status and inflammatory markers
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    Atherosclerosis 169:169-74. 2003
    ..In ostensibly healthy adults, B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules, or thrombogenic factors...
  81. pmc Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme
    Rosa A Vacca
    Institute of Biomembranes and Bioenergetics, CNR, Via Amendola 165 A, I 70126 Bari, Italy
    BMC Biochem 9:17. 2008
    ..Here we report on an attempt to re-enact the emergence of a PLP-dependent protoenzyme. The starting protein was pancreatic ribonuclease A (RNase), in which active-site Lys41 or Lys7 readily form a covalent adduct with PLP...
  82. pmc Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008
    ..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas...
  83. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
    ..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
  84. ncbi Homocysteine lowering and cardiovascular events after acute myocardial infarction
    Kaare Harald Bønaa
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    N Engl J Med 354:1578-88. 2006
    ..Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction...
  85. ncbi Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer
    Stefan de Vogel
    Department of Epidemiology, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Carcinogenesis 29:1765-73. 2008
    ....
  86. ncbi Vitamin B6 suppresses apoptosis of NM-1 bovine endothelial cells induced by homocysteine and copper
    Naoko Endo
    Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1770:571-7. 2007
    ..These results suggest that pyridoxal treatment suppresses apoptosis of NM-1 cells induced by homocysteine and copper, most likely through antioxidant effects...
  87. ncbi The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants
    Shari S Bassuk
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 13:99-117. 2004
    ..Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women...
  88. ncbi [An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children]
    Rafael Garcia-Lopez
    Departamento de Anestesia y Reanimación Hospital Costa del Sol Marbella Málaga España
    Med Clin (Barc) 131:689-91. 2008
    ..We also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group...
  89. pmc Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis
    Susan Wagner
    Angewandte Genetik, Freie Universitat Berlin, 14195 Berlin, Germany
    Plant Cell 18:1722-35. 2006
    ..In summary, our results demonstrate the critical function of the PDX1 protein family for metabolism, whole-plant development, and vitamin B6 biosynthesis in higher plants...
  90. ncbi Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men
    Junko Ishihara
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Nutr 137:1808-14. 2007
    ..Our results support previous evidence that low vitamin B-6 intake is associated with an increased risk of colorectal cancer. In particular, a higher intake of vitamin B-6 appears beneficial in men with higher alcohol intake...
  91. ncbi Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia
    Mustafa Hakan Dinckal
    Department of Cardiology, Medical Faculty of Gaziantep University, Gaziantep, Turkey
    Acta Cardiol 58:389-96. 2003
    ..This study was performed to determine the effect of homocysteine-lowering therapy (HLT) on endothelium-dependent vasodilation (EDD) and exercise performance in patients with coronary artery disease...
  92. ncbi Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women
    Eunyoung Cho
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:2787-90. 2007
    ..In conclusion, we found no evidence that higher intakes of nutrients involved in one-carbon metabolism reduce risk of breast cancer among premenopausal women...
  93. ncbi Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12
    Uwe Till
    Institute of Pathobiochemistry, Friedrich Schiller University, Postfach, Jena, Germany
    Atherosclerosis 181:131-5. 2005
    ..Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce...
  94. ncbi Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator
    R Chumnantana
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
    Biochim Biophys Acta 1722:84-91. 2005
    ..The antioxidant function of pyridoxal 5'-phosphate was not dependent on the phosphorelay pathway, which finally triggers the expression of the catalase gene...
  95. ncbi Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes
    Krishnaswamy Kannan
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 36:423-8. 2004
    ..B6 compounds can prevent the oxygen radical generation and lipid peroxidation caused by hydrogen peroxide in U937 monocytes, and that some of the protective effect of Vit.B6 may occur via modification of mitochondrial function...
  96. ncbi Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    James F Toole
    Stroke Research Center, Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:565-75. 2004
    ..However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials...
  97. ncbi The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditions
    B L Grimaldi
    Med Hypotheses 58:47-60. 2002
    ....
  98. ncbi Biochemistry of homocysteine in health and diseases
    S Ramakrishnan
    Biochemistry Research Department, Vision Research Foundation, Sankara Nethralaya, Chennai 600 006, India
    Indian J Biochem Biophys 43:275-83. 2006
    ....
  99. ncbi The short-rooted vitamin B6-deficient mutant pdx1 has impaired local auxin biosynthesis
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Planta 229:1303-10. 2009
    ..These data indicate that pdx1 is impaired in Trp-dependent auxin biosynthesis, which may contribute to the short-root phenotype of pdx1. We suggest that locally synthesized auxin may play a critical role in postembryonic root growth...
  100. ncbi Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6
    Susana Rodriguez-Navarro
    Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, C Dr Moliner 50, E 46100, Burjassot, Spain
    Yeast 19:1261-76. 2002
    ..Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase...
  101. ncbi Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial
    Andrew H Ford
    South Metropolitan Health Service, Perth, Australia
    J Clin Psychiatry 69:1203-9. 2008
    ..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression...

Research Grants62

  1. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  2. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ....
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy in OC users and will provide a metabolically validated supplementation strategy to alleviate low B6 status and promote health in OC users. ..
  4. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..abstract_text> ..
  5. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..This research will fill an important data gap by launching forward our knowledge regarding etiologies of CS and providing direction for the next generation of studies of CS. ..
  6. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  7. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..Discovery that plant/fungal toxins can promote seizures in individuals prone to epileptic attacks would have relevance in the prevention and treatment of epileptic disorders worldwide. ..
  8. Molecular Pathogenesis and Treatment of Hypophosphatasia
    Jose Luis Millan; Fiscal Year: 2013
    ..The novel TNAP activators that we have discovered may prove of interest for the prevention and treatment of osteoporosis. ..
  9. Chemically-Rich Structure and Dynamics in the Active Site of Tryptophan Synthase
    Leonard J Mueller; Fiscal Year: 2013
    ....
  10. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010
    ..Sc.D., a well-known epidemiologist with an interest in HTN. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in HTN research. (End of Abstract) ..
  11. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  12. The role of GABA-mimetic metabolites in neurodevelopmental and neuropsychiatric d
    Joseph A Gogos; Fiscal Year: 2013
    ..These results will also lay the foundation for guiding future studies targeted at the development of pharmacological rescue strategies for these diseases. ..
  13. One-carbon metabolism biomarkers and lung cancer risk
    PAUL JOSEPH BRENNAN; Fiscal Year: 2013
    ..The important work that will go into the construction of this consortium will also result in opportunities to initiate additional studies concerning lung cancer etiology. ..
  14. Nutrition and Oral Clefts in Asia: Planning Grant
    Ronald G Munger; Fiscal Year: 2010
    ..The long-term goal of our research team is to elucidate the role of common maternal nutritional and metabolic factors in oral clefts as a prerequisite to developing preventive measures. ..
  15. REACTION SPECIFICITY OF PYRIDOXAL PHOSPHATE ENZYMES
    MICHAEL TONEY; Fiscal Year: 2011
    ..Our studies will provide the fundamental knowledge required to target these enzymes highly specifically with small molecule drugs. ..
  16. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William G Christen; Fiscal Year: 2012
    ....
  17. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2010
    ..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..
  18. MECHANISMS & INHIBITORS OF PYRIDOXAL-DEPENDENT ENZYMES
    DAVID METZLER; Fiscal Year: 1993
    ....
  19. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  20. REGULATION OF PYRIDOXAL PHOSPHATE BIOSYNTHESIS IN E COLI
    Malcolm Winkler; Fiscal Year: 1999
    ..Finally, this project is of biomedical and biotechnological relevance, because PLP plays well- documented, diverse roles in human intermediary metabolism, physiology, and disease. ..
  21. GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINE
    Warren Kruger; Fiscal Year: 2009
    ..Cystathionine beta-synthase (CBS) is a key enzyme in the metabolism of homocysteine. In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. ..
  22. VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGE
    Terry Shultz; Fiscal Year: 2002
    ....
  23. CHELATION THERAPY OF IRON OVERLOAD WITH PIH
    Gary Brittenham; Fiscal Year: 1993
    ....
  24. VITAMIN B-6 AND STERIOD HORMONE ACTION
    JOHN CIDLOWSKI; Fiscal Year: 1991
    ....
  25. RELATION OF DIET TO SERUM HOMOCYSTEINE LEVEL IN YOUTHS
    Stavroula Osganian; Fiscal Year: 2001
    ..African Americans vs. Hispanics. Information generated by this study will be valuable for designing specific dietary interventions for youth and targeting subgroups of children who may be at higher risk for CVD. ..
  26. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2007
    ..The public health implications of this study are in its contributions to preventing common kidney stone disease, and preventing kidney failure in an orphan disease, Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  27. PERTURBATIONS IN VITAMIN B6 METABOLISM IN CANCER
    LOUISE NUTTER; Fiscal Year: 2000
    ....
  28. Novel Vitamin B6 based prodrugs of gemcitabine
    SHAWN PATRICK ZINNEN; Fiscal Year: 2013
    ..It is anticipated that this technology will ultimately result in therapeutic agents that will significanty improve the outcomes of cancer patients. ..
  29. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..
  30. REGULATION OF MAMMALIAN PYRIDOXAL PHOSPHATE METABOLISM
    MARGARET FONDA; Fiscal Year: 1980
    ..The possibility of product inhibition, feedback inhibition, and substrate activation of these enzymes will be studied to elucidate their role in control of vitamin B6 metabolism...
  31. BIOSYNTHESIS OF VITAMIN B1 AND VITAMIN B6
    IAN SPENSER; Fiscal Year: 2000
    ..It is the long term objective of the study to identify the step in each pathway which is blocked in human tissues, thereby making the compounds Vitamins. ..
  32. TRIAL OF ANTIOXIDANT THERAPY OF CVD IN WOMEN
    JoAnn Manson; Fiscal Year: 2005
    ..With the gaps in knowledge this study is intended to address and the certain intense interest in its findings by the medical, lay, and regulatory communities, the proposed extension of this trial in women is both important and timely. ..
  33. HYPERHOMOCYSTEINEMIA IN PREGNANCY AND PREECLAMPSIA
    James Roberts; Fiscal Year: 2001
    ..These studies could provide insight into what appears to be a unique sensitivity to endothelial dysfunction during pregnancy and whether acute (during pregnancy) insults are as important as life long exposure. ..
  34. VITAMIN B6 IN DEVELOPMENT OF CENTRAL NERVOUS SYSTEM
    Avanelle Kirksey; Fiscal Year: 1980
    ..Myelination patterns in the spinal cord using ultrastructural morphometric measurements will be correlated with specific activity of the CNS myelin marker enzyme, 2',3'-cyclic nucleotide 3'-phosphohydrolase...
  35. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  36. VITAMIN B-6 NUTRITIONAL STATUS ASSESSMENT IN PREGNANCY
    Andrew Smolen; Fiscal Year: 1993
    ..Currently, there are no generally acceptable tests of vitamin B-6 nutritional status in pregnancy, and the goal of this application is to assess the utility of several potential status indicators...
  37. LONG ORAL CONTRACEPTIVE USE/VITAMIN B-6 PREGNANCY NEEDS
    Avanelle Kirksey; Fiscal Year: 1980
    ....
  38. Renal Transplantation, Homocysteine Lowering & Cognition
    Irwin Rosenberg; Fiscal Year: 2007
    ..Demonstrating the cognitive benefits of lowering homocysteine may pave the way to nutritional modification of cognitive decline in RTRs and other high-risk groups and even in the general population. ..
  39. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  40. Prevention of osteoporosis with novel bisphosphonates
    THERESA HEFFERAN; Fiscal Year: 2004
    ....
  41. THE GENETICS OF PREGNANCY-INDUCED SEIZURES IN MICE
    Andrew Smolen; Fiscal Year: 1992
    ..Two strains of mice which differ in susceptibility to pregnancy-induced seizures will be used to study the relationship between vitamin B6 nutritional status and neurochemical adjustments which occur during pregnancy...
  42. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2006
    ..The contributions of beta- amino acids produced by lysine 2,3-aminomutase and arginine 2,3-aminomutase to the functions of antibiotics are not known. The beta-aminoacids may become significant in drug development. ..
  43. VITAMIN B-6 STATUS IN PREGNANCY, LACTATION AND INFANCY
    PHYLIS MOSER VEILLON; Fiscal Year: 1993
    ....
  44. NEURAL CONTROL OF POSTURE AND STANCE
    JANE MACPHERSON; Fiscal Year: 2002
    ..Further, this understanding may lead to new ideas and rehabilitation techniques for improving balance in these patients. ..
  45. Vitamin B6 Biosynthesis: A study of the pdxJ Mechanism
    VALERIE FRYDRYCHOWSKI BURKE; Fiscal Year: 2002
    ..Isolation and characterization of these intermediates is expected to delineate the detailed mechanistic pathway from 1-aminoacetone-3-phosphate and 1-deoxy-D-xylulose to pyridoxine 5-phosphate. ..
  46. Responsivity of homocysteine to behavioral stress
    Charles Emery; Fiscal Year: 2005
    ..abstract_text> ..
  47. ETHANOL EFFECTS ON VITAMIN TRANSPORT/MITOGENIC SIGNALING
    George Henderson; Fiscal Year: 1993
    ..Inhibition of this process by ethanol may explain, at least in part, the adverse effects of in utero ethanol exposure on the fetus...
  48. MATERNAL B6 DEFICIENCY
    TOMAS GUILARTE; Fiscal Year: 1993
    ..These studies will continue to provide new and valuable information on the role that vitamin B-6 plays in brain function and development...
  49. MBRS SCORE PROGRAM AT TEXAS A&M UNIVERSITY-KINGSVILLE
    Enrique Massa; Fiscal Year: 2010
    ..abstract_text> ..
  50. EFFECT OF FOLIC ACID AND VITAMIN B6 ON HOMOCYSTEINE
    LAVERNE SCHIRCH; Fiscal Year: 2004
    ....
  51. Novel Bisphosphonates for Multiple Myeloma Therapy
    MONICA REINHOLZ; Fiscal Year: 2004
    ..Successful development of this new drug-design concept would provide a biologically and commercially superior approach for the treatment and prevention of skeletal-related complications of malignancy. ..
  52. Novel bisphosphonates for prostate cancer therapy
    Alexander Karpeisky; Fiscal Year: 2007
    ..Thus, the development of these therapeutics may not only improve the quality of life for prostate cancer patients but may also prolong their lives. [unreadable] [unreadable] [unreadable]..
  53. One-carbon nutrients in cancer prevention
    Joel Mason; Fiscal Year: 2007
    ..abstract_text> ..
  54. Novel Bisphosphonates for Breast Cancer Therapy
    MONICA REINHOLZ; Fiscal Year: 2002
    ..Proposed Commercial Application: Not Available. ..