vitamin b 6

Summary

Summary: VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.

Top Publications

  1. ncbi Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis
    Kathleen Woolf
    Arizona State University Department of Nutrition, 6950 E Williams Field Rd, Mesa, AZ 85212, USA
    J Am Diet Assoc 108:443-53; discussion 454. 2008
  2. ncbi Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution
    Young Min Jang
    Department of Biochemistry, Kyungpook National University, Taegu 702 701, Korea
    J Biol Chem 278:50040-6. 2003
  3. ncbi The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber
    B Sturtzel
    Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austsria
    J Nutr Health Aging 14:219-23. 2010
  4. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
  5. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
  6. ncbi Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase
    Jeong Han Kang
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Eur J Biochem 271:2452-61. 2004
  7. pmc Vitamin B6 is associated with depressive symptomatology in Massachusetts elders
    CRISTINA MERETE
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 27:421-7. 2008
  8. pmc Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
  9. ncbi Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana
    Antoine Danon
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092 Zurich, Switzerland
    Plant J 41:68-80. 2005
  10. pmc Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:794-9. 2010

Research Grants

Detail Information

Publications236 found, 100 shown here

  1. ncbi Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis
    Kathleen Woolf
    Arizona State University Department of Nutrition, 6950 E Williams Field Rd, Mesa, AZ 85212, USA
    J Am Diet Assoc 108:443-53; discussion 454. 2008
    ..Elevated plasma homocysteine, a risk factor for cardiovascular disease, may help explain why individuals with rheumatoid arthritis have an increased risk of cardiovascular disease...
  2. ncbi Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution
    Young Min Jang
    Department of Biochemistry, Kyungpook National University, Taegu 702 701, Korea
    J Biol Chem 278:50040-6. 2003
    ..1 kb was detected in all human tissues examined and was highly abundant in the brain. Obtaining the molecular properties for the human PLP phosphatase may provide new direction for investigating metabolic pathway involving vitamin B6...
  3. ncbi The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber
    B Sturtzel
    Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austsria
    J Nutr Health Aging 14:219-23. 2010
    ..Vitamin B12 deficiency as a digestive disorder and constipation as a gastro motility disorder are common in the elderly. Laxative treatment is often chosen without regard for gut health...
  4. ncbi B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ....
  5. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
    ..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
  6. ncbi Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase
    Jeong Han Kang
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Eur J Biochem 271:2452-61. 2004
    ..Our results showed that deletion of the N-terminal 56 residues affects neither the binding of coenzyme nor catalytic activity...
  7. pmc Vitamin B6 is associated with depressive symptomatology in Massachusetts elders
    CRISTINA MERETE
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 27:421-7. 2008
    ....
  8. pmc Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
    ..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved...
  9. ncbi Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana
    Antoine Danon
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092 Zurich, Switzerland
    Plant J 41:68-80. 2005
    ....
  10. pmc Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:794-9. 2010
    ..Long interspersed nucleotide element-1 (LINE-1) is an emerging indicator of genome-wide DNA methylation level that has previously been linked to colon cancer survival...
  11. ncbi Two independent routes of de novo vitamin B6 biosynthesis: not that different after all
    Teresa B Fitzpatrick
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Biochem J 407:1-13. 2007
    ..Surprisingly, this comparison reveals that the key biosynthetic enzymes of both pathways are, in fact, very similar both structurally and mechanistically...
  12. ncbi Vitamin B6 status, deficiency and its consequences--an overview
    A Spinneker
    Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain
    Nutr Hosp 22:7-24. 2007
    ..Nowadays, clinically evident vitamin B6 deficiency is not a common disorder, at least in the general population. Nevertheless, a subclinical, undiagnosed deficiency may be present in some subjects, particularly in the elderly...
  13. ncbi Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan
    Y C Huang
    School of Nutrition, Chung Shan Medical University, Taiwan, Republic of China
    Eur J Clin Nutr 56:387-92. 2002
    ..To assess vitamin B6 intake and status of critically ill patients. The relationship between vitamin B6 status indicators and the severity of illness and outcome in these patients was also examined...
  14. ncbi The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty
    Andrew Gray
    Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Nutr 23:1080-3. 2004
    ..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
  15. ncbi Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response
    Dinesh Talwar
    Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Clin Chem 49:515-8. 2003
  16. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  17. ncbi Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill
    Yi Chia Huang
    School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Nutrition 21:779-85. 2005
    ..This study assessed the effect of vitamin B6 status on immune responses in mechanically ventilated, critically ill patients and compared the results with those of healthy controls...
  18. ncbi Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study
    Anita C Peeters
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Vasc Surg 45:701-5. 2007
    ....
  19. ncbi Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants
    Simone Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Am J Gastroenterol 98:112-7. 2003
    ..The aim of this study was to evaluate vitamin B(6) plasma levels in IBD patients...
  20. pmc Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adults
    Xingwang Ye
    Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
    J Am Diet Assoc 110:1660-8. 2010
    ..Vitamin B-6 is an important cofactor in many metabolic processes. However, vitamin B-6 intake and plasma status have not been well studied in the Puerto Rican population, a group with documented health disparities...
  21. doi Quantification of vitamin B6 vitamers in human cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometry
    M Van der Ham
    Department of Metabolic Diseases and Netherlands Metabolomics Center, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Anal Chim Acta 712:108-14. 2012
    ..The method was applied to CSF samples of 20 subjects and two patients on pyridoxine supplementation. Using minimal CSF volumes this method is suitable for implementation in a routine diagnostic setting...
  22. doi Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells
    Noriyuki Yanaka
    Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    Mol Nutr Food Res 55:635-43. 2011
    ..Previous reports in the areas of animal studies and, recently epidemiology, have linked anti-tumorigenic and anti-inflammatory effects to dietary vitamin B6. This study investigated the molecular mechanism of these effects of vitamin B6...
  23. doi Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms
    Solveig C Ligaarden
    Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway
    Nutr Res 31:356-61. 2011
    ..583; β = -4.431; 95% confidence interval, -6.386 to -2.476; P = 0.0002). A significant inverse association between intake of vitamin B₆ and severity of IBS symptoms might have clinical implications...
  24. doi Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial
    Gustavo Saposnik
    Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 40:1365-72. 2009
    ..Our aim was to determine whether vitamin therapy reduces the risk of ischemic and hemorrhagic stroke, as well as stroke-related disability...
  25. ncbi ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins
    Karsten Sydow
    Department of Cardiology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Cardiovasc Res 57:244-52. 2003
    ..We investigated whether oral treatment with B vitamins or L-arginine normalizes endothelium-dependent, flow-dependent vasodilation (FDD) in patients with peripheral arterial occlusive disease (PAOD) and hyperhomocyst(e)inemia...
  26. pmc A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
    Todd M Gibson
    Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
    Cancer Causes Control 21:1061-9. 2010
    ..We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50-69 at baseline...
  27. ncbi 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase
    Jeremiah W Hanes
    Department of Chemistry and Chemical Biology, Cornell University, 120 Baker Laboratory, Ithaca, New York 14853, USA
    Nat Chem Biol 4:425-30. 2008
    ..This analysis revealed a new 1,5 migration of the lysine amine linking the intermediate to the enzyme during the conversion of ribose 5-phosphate to pyridoxal 5'-phosphate...
  28. ncbi Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Med 114:283-7. 2003
    ..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
  29. ncbi Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate
    Thomas Raschle
    Institute of Plant Sciences, ETH Zurich, 8092 Zurich
    J Biol Chem 282:6098-105. 2007
    ..Two alternative structures are proposed for the chromophoric intermediate, both of which require substantial modifications of the proposed mechanism...
  30. ncbi Antitumor effect of vitamin B6 and its mechanisms
    S Komatsu
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima 739 8528, Japan
    Biochim Biophys Acta 1647:127-30. 2003
    ..The results suggest that dietary vitamin B(6) suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis...
  31. ncbi Folate therapy and in-stent restenosis after coronary stenting
    Helmut Lange
    Kardiologische Praxis, Klinikum Links der Weser, Heart Center, Bremen, Germany
    N Engl J Med 350:2673-81. 2004
    ..We tested the effect of a combination of folic acid, vitamin B6, and vitamin B12 (referred to as folate therapy) on the risk of angiographic restenosis after coronary-stent placement in a double-blind, multicenter trial...
  32. pmc Vitamin B6 biosynthesis in higher plants
    Marina Tambasco-Studart
    Institute of Plant Sciences, Swiss Federal Institute of Technology ETH, Universitatstrasse 2, CH 8092 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:13687-92. 2005
    ..Furthermore, and contrary to what was inferred previously, we show that the pathway appears to be cytosolic and is not localized to the plastid. Last, we report that the single PDX2 homolog is essential for plant viability...
  33. ncbi PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis
    Olca Titiz
    ETH Zurich, Institute of Plant Science, 8092 Zurich, Switzerland
    Plant J 48:933-46. 2006
    ..Furthermore, we provide evidence that in addition to being essential for plant growth and development, vitamin B6 also plays a role in stress tolerance and photoprotection of plants...
  34. pmc Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
    Cheryll Perry
    Cornell University, Division of Nutritional Science, Ithaca, NY 14853, USA
    Arch Biochem Biophys 462:21-7. 2007
    ..Collectively, these data indicate that vitamin B(6) restriction decreases the activity and stability of SHMT, and that the cytoplasmic isozyme is more sensitive to vitamin B(6) deficiency than the mitochondrial isozyme in MCF-7 cells...
  35. pmc Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway
    Eugenia González
    Department of Plant Biology, North Carolina State University, Raleigh, North Carolina 27695 7612, USA
    Plant Physiol 145:985-96. 2007
    ..Increased expression of salvage and some of the de novo pathway genes was observed in both the pdx3 and sos4 mutants. In all mutants, increased expression was more dramatic for the salvage pathway genes...
  36. ncbi Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:1056-9. 2003
    ..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
  37. ncbi The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo biloba
    Jan E Leuendorf
    Angewandte Genetik, Freie Universitat, Berlin, Germany
    FEBS J 275:960-9. 2008
    ..Overall, this study provides a first description of Ginkgo vitamin B6 metabolism, and demonstrates a high degree of conservation between Ginkgo and Arabidopsis...
  38. doi Cancer incidence and mortality after treatment with folic acid and vitamin B12
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
    JAMA 302:2119-26. 2009
    ..Recently, concern has been raised about the safety of folic acid, particularly in relation to cancer risk...
  39. ncbi Homocysteine lowering with folic acid and B vitamins in vascular disease
    Eva Lonn
    Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
    N Engl J Med 354:1567-77. 2006
    ..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
  40. ncbi The many facets of hyperhomocysteinemia: studies from the Framingham cohorts
    Jacob Selhub
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 136:1726S-1730S. 2006
    ..Whether this denominator is homocysteine itself or whether homocysteine is merely a marker remains to be determined...
  41. ncbi High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 82:627-35. 2005
    ..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
  42. ncbi Homocysteine lowering and cardiovascular events after acute myocardial infarction
    Kaare Harald Bønaa
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    N Engl J Med 354:1578-88. 2006
    ..Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction...
  43. ncbi B vitamin status and inflammatory markers
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    Atherosclerosis 169:169-74. 2003
    ..In ostensibly healthy adults, B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules, or thrombogenic factors...
  44. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
    ..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
  45. pmc Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008
    ..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas...
  46. pmc Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme
    Rosa A Vacca
    Institute of Biomembranes and Bioenergetics, CNR, Via Amendola 165 A, I 70126 Bari, Italy
    BMC Biochem 9:17. 2008
    ..Here we report on an attempt to re-enact the emergence of a PLP-dependent protoenzyme. The starting protein was pancreatic ribonuclease A (RNase), in which active-site Lys41 or Lys7 readily form a covalent adduct with PLP...
  47. ncbi Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer
    Stefan de Vogel
    Department of Epidemiology, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Carcinogenesis 29:1765-73. 2008
    ....
  48. ncbi Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial
    Andrew H Ford
    South Metropolitan Health Service, Perth, Australia
    J Clin Psychiatry 69:1203-9. 2008
    ..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression...
  49. ncbi Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator
    R Chumnantana
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
    Biochim Biophys Acta 1722:84-91. 2005
    ..The antioxidant function of pyridoxal 5'-phosphate was not dependent on the phosphorelay pathway, which finally triggers the expression of the catalase gene...
  50. ncbi Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women
    Martin Lajous
    Instituto Nacional de Salud Publica, Av Universidad 655, Col Santa Maria Ahuacatitlan, Cuernavaca, Morelos 62508, Mexico
    Cancer Epidemiol Biomarkers Prev 15:443-8. 2006
    ..We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes...
  51. doi The short-rooted vitamin B6-deficient mutant pdx1 has impaired local auxin biosynthesis
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Planta 229:1303-10. 2009
    ..These data indicate that pdx1 is impaired in Trp-dependent auxin biosynthesis, which may contribute to the short-root phenotype of pdx1. We suggest that locally synthesized auxin may play a critical role in postembryonic root growth...
  52. ncbi Vitamin B6 suppresses apoptosis of NM-1 bovine endothelial cells induced by homocysteine and copper
    Naoko Endo
    Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1770:571-7. 2007
    ..These results suggest that pyridoxal treatment suppresses apoptosis of NM-1 cells induced by homocysteine and copper, most likely through antioxidant effects...
  53. ncbi Effect of high-glucose levels on protein oxidation in cultured lens cells, and in crystalline and albumin solution and its inhibition by vitamin B6 and N-acetylcysteine: its possible relevance to cataract formation in diabetes
    Aman K Jain
    Caddo Magnet High School, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1615-21. 2002
    ..This study explains the cause of early cataract development and the potential benefit of supplementation with vitamin B6 and NAC in the prevention of the development of cataract among the diabetic population...
  54. ncbi [An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children]
    Rafael Garcia-Lopez
    Departamento de Anestesia y Reanimación Hospital Costa del Sol Marbella Málaga España
    Med Clin (Barc) 131:689-91. 2008
    ..We also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group...
  55. ncbi The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants
    Shari S Bassuk
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 13:99-117. 2004
    ..Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women...
  56. ncbi Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago
    Clin Cardiol 25:495-501. 2002
    ..The relationship between hyperhomocysteinemia and cardiovascular disease has not been totally elucidated...
  57. ncbi Biochemistry of homocysteine in health and diseases
    S Ramakrishnan
    Biochemistry Research Department, Vision Research Foundation, Sankara Nethralaya, Chennai 600 006, India
    Indian J Biochem Biophys 43:275-83. 2006
    ....
  58. ncbi Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia
    Mustafa Hakan Dinckal
    Department of Cardiology, Medical Faculty of Gaziantep University, Gaziantep, Turkey
    Acta Cardiol 58:389-96. 2003
    ..This study was performed to determine the effect of homocysteine-lowering therapy (HLT) on endothelium-dependent vasodilation (EDD) and exercise performance in patients with coronary artery disease...
  59. ncbi Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes
    Krishnaswamy Kannan
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 36:423-8. 2004
    ..B6 compounds can prevent the oxygen radical generation and lipid peroxidation caused by hydrogen peroxide in U937 monocytes, and that some of the protective effect of Vit.B6 may occur via modification of mitochondrial function...
  60. ncbi Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus
    Karen E MacKenzie
    Department of Diabetes and Endocrinology, Children, Youth, and Women s Health Service, Adelaide, Australia
    Pediatrics 118:242-53. 2006
    ..Endothelial dysfunction, a precursor of vascular disease, begins early in type 1 diabetes mellitus and is associated with folate status...
  61. ncbi Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    James F Toole
    Stroke Research Center, Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:565-75. 2004
    ..However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials...
  62. pmc Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis
    Susan Wagner
    Angewandte Genetik, Freie Universitat Berlin, 14195 Berlin, Germany
    Plant Cell 18:1722-35. 2006
    ..In summary, our results demonstrate the critical function of the PDX1 protein family for metabolism, whole-plant development, and vitamin B6 biosynthesis in higher plants...
  63. ncbi On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis
    Thomas Raschle
    ETH Zurich, Institut für Pflanzenwissenschaften, Zurich, Switzerland
    J Biol Chem 280:32291-300. 2005
    ..The results are discussed in light of the nature of the interaction of the two components of the enzyme complex...
  64. ncbi Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6
    Susana Rodriguez-Navarro
    Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, C Dr Moliner 50, E 46100, Burjassot, Spain
    Yeast 19:1261-76. 2002
    ..Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase...
  65. ncbi Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women
    Eunyoung Cho
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:2787-90. 2007
    ..In conclusion, we found no evidence that higher intakes of nutrients involved in one-carbon metabolism reduce risk of breast cancer among premenopausal women...
  66. ncbi Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men
    Junko Ishihara
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Nutr 137:1808-14. 2007
    ..Our results support previous evidence that low vitamin B-6 intake is associated with an increased risk of colorectal cancer. In particular, a higher intake of vitamin B-6 appears beneficial in men with higher alcohol intake...
  67. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  68. ncbi The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditions
    B L Grimaldi
    Med Hypotheses 58:47-60. 2002
    ....
  69. ncbi Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12
    Uwe Till
    Institute of Pathobiochemistry, Friedrich Schiller University, Postfach, Jena, Germany
    Atherosclerosis 181:131-5. 2005
    ..Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce...
  70. ncbi Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial
    Guido Schnyder
    Division of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Switzerland
    JAMA 288:973-9. 2002
    ....
  71. doi Vitamin B6: a long known compound of surprising complexity
    Sutton Mooney
    School of Biological Sciences, Washington State University, Pullman, WA, USA
    Molecules 14:329-51. 2009
    ....
  72. ncbi Serum total homocysteine levels, folate, and B-vitamins intake and coronary heart disease risk factors among tri-ethnic college students
    Samer Koutoubi
    Nutrition Department, Bastyr University, Kenmore, Washington 98028, USA
    Ethn Dis 14:64-72. 2004
    ..009), and Black non-Hispanic females (P=.005). We observed gender and ethnic differences in tHcy levels of this young population with normal tHcy levels. Abnormally high tHcy concentrations appear to be acquired later in life...
  73. ncbi [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]
    Alba Rosa Morón de Salim
    Departamento de Bioquimica, Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Estado Carabobo, Venezuela
    Arch Latinoam Nutr 55:28-33. 2005
    ..of vitamins B12, B6 and folic acid, may is effective in decreased plasmatic homocysteine levels and lipids, mainly triglycerides, with a reduction of coronary risk, to these type of patients, with not collateral effects of neuropathy..
  74. ncbi Plasma homocysteine levels and vitamin B status in patients with Pseudoexfoliation syndrome
    M Sinan Saricaoglu
    Third Eye Clinic, Ankara Numune Training ana Research Hospital, Sihhiye, Ankara, Turkey
    Saudi Med J 27:833-7. 2006
    ....
  75. ncbi Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation
    Pal I Holm
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Arterioscler Thromb Vasc Biol 24:301-7. 2004
    ..Betaine is a substrate in the betaine-homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine (tHcy) concentration...
  76. pmc Total homocysteine, diet, and lipid profiles in type 1 and type 2 diabetic and nondiabetic adolescents
    Melissa Spezia Faulkner
    College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Cardiovasc Nurs 21:47-55. 2006
    ....
  77. ncbi Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults
    Cynthia M Carlsson
    Section of Cardiovascular Medicine, University of Wisconsin Medical School, and the Veterans Affairs Geriatrics Research, Education, and Clinical Center GRECC, Madison, Wis 53705, USA
    Am Heart J 148:E11. 2004
    ..The objective of this study was to determine the effects of multivitamins (MV) and folic acid (FA) supplements on flow-mediated vasodilation (FMD) in older adults...
  78. ncbi Eat right and exercise for lower homocysteine levels and less chance of heart disease
    Samer Koutoubi
    Ethn Dis 14:160. 2004
  79. ncbi Water-soluble vitamins: research update
    Eugene J Bruno
    Huntington College of Health Sciences, 1101 S Milliken, Ste A, Ontario, CA 91761, USA
    Curr Sports Med Rep 4:207-13. 2005
    ....
  80. ncbi [Efficacy and safety of two vitamin supplement regimens on homocysteine levels in hemodialysis patients. Prospective, randomized clinical trial]
    J E Sánchez Alvarez
    Hospital Tamaragua, Tenerife
    Nefrologia 25:288-96. 2005
    ..Moreover, methylenetetrahydrofolate reductase (MTHFR) gene polymorphism can modulate its prevalence and response to treatment...
  81. ncbi Do low doses of folic acid result in maximum lowering of homocysteine?
    Lynn B Bailey
    Am J Clin Nutr 82:717-8. 2005
  82. ncbi Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years
    Maike Wolters
    Nutrition Physiology and Human Nutrition Unit, Institute of Food Science Centre of Applied Chemistry University of Hanover, Wunstorfer Str 14, 30453, Hannover, Germany
    Eur J Nutr 44:183-92. 2005
    ..Studies have shown that supplementation of the three vitamins can lower tHcy even in subjects with tHcy in the normal range...
  83. ncbi [Group B vitamins as new variables related to the cardiovascular risk]
    Monica Granieri
    Istituto di Cardiologia, Universita degli Studi G D Annunzio, Chieti
    Ital Heart J Suppl 6:1-16. 2005
    ..A further confirmation of these data is important to devise future intervention strategies in primary and secondary prophylaxis of atherosclerotic vascular disease...
  84. ncbi Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial
    Rajesh Ullegaddi
    Sheffield Institute for Nutritional Studies on Ageing and the Human Nutrition Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK
    JPEN J Parenter Enteral Nutr 30:108-14. 2006
    ..Several studies point to an antioxidant effect of B-group vitamins and a pro-oxidant effect of elevated total plasma homocysteine (tHcy)...
  85. ncbi Plasma homocysteine levels and risk of Alzheimer disease
    J A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, USA
    Neurology 62:1972-6. 2004
    ..To explore the association between high homocysteine levels and risk of Alzheimer disease (AD) in the Washington Heights-Inwood Columbia Aging Project (WHICAP)...
  86. pmc Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial
    E Lonn
    Hamilton Health Sciences Corporation, Hamilton, Ontario
    Can J Cardiol 22:47-53. 2006
    ..Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events...
  87. ncbi Association of B vitamins status and homocysteine levels in elderly Taiwanese
    Kuan Ju Chen
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan
    Asia Pac J Clin Nutr 14:250-5. 2005
    ....
  88. ncbi Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    David J Stott
    Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
    Am J Clin Nutr 82:1320-6. 2005
    ..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
  89. ncbi [Homocysteine and neuropsychiatric disorders]
    Perminder Sachdev
    Faculdade de Psiquiatria, Universidade de New South Wales, Sydney, Australia
    Rev Bras Psiquiatr 26:50-6. 2004
    ..More research evidence is necessary before population screening can be recommended...
  90. ncbi Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients
    Grace Y H Ho
    Department of Neurology, Singapore General Hospital, Singapore
    Stroke 37:456-60. 2006
    ....
  91. ncbi Vitamins and minerals 4: overview of folate and the B vitamins
    June Thompson
    Community Pract 79:197-8. 2006
    ..In the fourth of an occasional series on vitamins, minerals and supplements, June Thompson looks at the role folate, in particular, may play in reducing homocysteine in the body and in protecting the body from some other diseases...
  92. ncbi DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations
    Olaf Stanger
    Landesklinik für Herzchirurgie, Landeskliniken Salzburg, Salzburg, Austria
    Clin Chem Lab Med 41:1392-403. 2003
    ..The results of ongoing randomized controlled intervention trials must be available before screening for, and treatment of, hyperhomocysteinemia can be recommended for the apparently healthy general population...
  93. ncbi [Risk factors for cardiovascular diseases: what is the role for homocysteine?]
    Maria Grazia Bendini
    U O di Cardiologia, Ospedale S Maria della Stella, Orvieto, TR
    G Ital Cardiol (Rome) 8:148-60. 2007
    ....
  94. ncbi [Nutritional medicine 2007]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Munchen, Germany
    Dtsch Med Wochenschr 132:1411-3. 2007
  95. ncbi Public health significance of elevated homocysteine
    Jacob Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Food Nutr Bull 29:S116-25. 2008
    ..Whether this denominator is homocysteine itself or homocysteine is merely a marker, remains to be determined...
  96. ncbi Emergent cardiovascular risk factor: homocysteine
    Cindy J Warren
    College of Nursing, Kent State University, Tuscarawas Campus, New Philadelphia, OH 44663, USA
    Prog Cardiovasc Nurs 17:35-41. 2002
    ..Risk factors for elevated homocysteine and intervention with B vitamins are discussed. Cardiovascular nurses are encouraged to facilitate homocysteine awareness through a variety of educational means...
  97. ncbi Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores
    Chien Jung Hung
    Department of Biochemistry, College of Medicine, Tzu Chi University, Hualien, Taiwan
    J Nutr 132:152-8. 2002
    ..7% of homocysteine variation. In conclusion, the Buddhist nuns who consumed a lacto-vegetarian diet had mildly elevated fasting plasma homocysteine levels presumably due to lower levels of plasma vitamin B-12...
  98. pmc Homocysteine lowering and cardiovascular disease risk: lost in translation
    Jeremy Marcus
    Department of Medicine, Division of Nephrology, Tufts New England Medical Centre, Boston, Massachusetts 02111, USA
    Can J Cardiol 23:707-10. 2007
    ..Several more interventional trials are ongoing, but the available data thus far do not support screening for or treatment of hyperhomocysteinemia...
  99. ncbi Association of plasma homocysteine and macular edema in type 2 diabetes mellitus
    E Aydin
    Department of Ophthalmology, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey
    Eur J Ophthalmol 18:226-32. 2008
    ..The aim of this study was to assess the association of macular edema (ME) with plasma homocysteine, vitamin B6, vitamin B12, and folic acid levels in patients with Type 2 diabetes...
  100. ncbi [Plasma homocysteine levels in patients with ischemic heart disease]
    L Mark
    Békés Megyei Képviselotestület Pándy Kálmán Kórháza, Gyula, II Belgyógyászat Kardiológia
    Orv Hetil 142:1611-5. 2001
    ..436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354)...
  101. ncbi [Homocysteine--a risk factor for atherosclerosis]
    L Debreceni
    ,
    Orv Hetil 142:1439-44. 2001
    ....

Research Grants82

  1. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  2. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2010
    ..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy in OC users and will provide a metabolically validated supplementation strategy to alleviate low B6 status and promote health in OC users. ..
  3. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2006
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  4. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2007
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  5. MECHANISMS & INHIBITORS OF PYRIDOXAL-DEPENDENT ENZYMES
    DAVID METZLER; Fiscal Year: 1993
    ....
  6. MECHANISMS & INHIBITORS OF PYRIDOXAL-DEPENDENT ENZYMES
    DAVID METZLER; Fiscal Year: 1990
    ....
  7. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2001
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  8. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2002
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  9. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2006
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  10. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2005
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  11. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2004
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  12. A Randomized, Controlled Trial for Homocysteine
    Andrew Bostom; Fiscal Year: 2003
    ..Accordingly, findings from the proposed trial are very likely to be generalizable to the much more sizable population of patients with renal insufficiency progressing to end-stage renal disease. ..
  13. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2002
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  14. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  15. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2003
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  16. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2001
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  17. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2007
    ..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
  18. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2009
    ..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
  19. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2006
    ..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
  20. Epidemiology of Abruptio Placentae in Peru
    Michelle Williams; Fiscal Year: 2006
    ..Folate and other B vitamins could be easily manipulated in the diet either by supplement use or by specific choice of foods if evidence from this and other studies indicates a benefit. [unreadable] [unreadable]..
  21. Molecular Pathogenesis and Treatment of Hypophosphatasia
    Jose Luis Millan; Fiscal Year: 2009
    ..In addition, we have uncovered novel activators of alkaline phosphatase function that can be developed into pharmaceuticals to increase bone mineral density in patients with hypophosphatasia and osteoporosis. ..
  22. Epidemiology of Abruptio Placentae in Peru
    Michelle Williams; Fiscal Year: 2007
    ..Folate and other B vitamins could be easily manipulated in the diet either by supplement use or by specific choice of foods if evidence from this and other studies indicates a benefit. [unreadable] [unreadable]..
  23. Risk Factors for Craniosynostosis
    Suzan Carmichael; Fiscal Year: 2009
    ..This proposal will improve our understanding of the causes of craniosynostosis, so that ultimately we will be able to prevent it and/or detect it as early as possible. ..
  24. REGULATION OF PYRIDOXAL PHOSPHATE BIOSYNTHESIS IN E COLI
    Malcolm Winkler; Fiscal Year: 1999
    ..Finally, this project is of biomedical and biotechnological relevance, because PLP plays well- documented, diverse roles in human intermediary metabolism, physiology, and disease. ..
  25. GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINE
    Warren Kruger; Fiscal Year: 2007
    ..In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINE
    Warren Kruger; Fiscal Year: 2006
    ..In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINE
    Warren Kruger; Fiscal Year: 2009
    ..Cystathionine beta-synthase (CBS) is a key enzyme in the metabolism of homocysteine. In this proposal we will develop new strategies and reagents to activate CBS thereby reducing plasma homocysteine levels. ..
  28. VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGE
    Terry Shultz; Fiscal Year: 2002
    ....
  29. VITAMIN B6 ADEQUACY, SMOKING AND DNA DAMAGE
    Terry Shultz; Fiscal Year: 2001
    ....
  30. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2010
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  31. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia Ulrich; Fiscal Year: 2009
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  32. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2000
    ..If the beta-aminoacyl substituents function in this way, they could become significant in drug delivery strategies, especially for candidate drugs that are minimally soluble. ..
  33. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2002
    ..If the beta-aminoacyl substituents function in this way, they could become significant in drug delivery strategies, especially for candidate drugs that are minimally soluble. ..
  34. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2001
    ..If the beta-aminoacyl substituents function in this way, they could become significant in drug delivery strategies, especially for candidate drugs that are minimally soluble. ..
  35. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 1999
    ..If the beta-aminoacyl substituents function in this way, they could become significant in drug delivery strategies, especially for candidate drugs that are minimally soluble. ..
  36. Vitamin B6 Effects on One-Carbon Metabolism
    JESSE GREGORY; Fiscal Year: 2007
    ..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy and will yield new information regarding nutritional dependence of human 1C metabolism. [unreadable] [unreadable]..
  37. Vitamin B6 Effects on One-Carbon Metabolism
    JESSE GREGORY; Fiscal Year: 2005
    ..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy and will yield new information regarding nutritional dependence of human 1C metabolism. ..
  38. Vitamin B6 Effects on One-Carbon Metabolism
    JESSE GREGORY; Fiscal Year: 2006
    ..These studies will expand our understanding of the functional impact of vitamin B6 inadequacy and will yield new information regarding nutritional dependence of human 1C metabolism. [unreadable] [unreadable]..
  39. Molecular Pathogenesis and Treatment of Hypophosphatasia
    Jose Luis Millan; Fiscal Year: 2012
    ..In addition, we have uncovered novel activators of alkaline phosphatase function that can be developed into pharmaceuticals to increase bone mineral density in patients with hypophosphatasia and osteoporosis. ..
  40. CHELATION THERAPY OF IRON OVERLOAD WITH PIH
    Gary Brittenham; Fiscal Year: 1990
    ....
  41. CHELATION THERAPY OF IRON OVERLOAD WITH PIH
    Gary Brittenham; Fiscal Year: 1993
    ....
  42. Molecular Pathogenesis and Treatment of Hypophosphatasia
    Jose Luis Millan; Fiscal Year: 2010
    ..In addition, we have uncovered novel activators of alkaline phosphatase function that can be developed into pharmaceuticals to increase bone mineral density in patients with hypophosphatasia and osteoporosis. ..
  43. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  44. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2001
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  45. SUPPLEMENT B-Vitamin Atherosclerosis Intervention Trial
    HOWARD HODIS; Fiscal Year: 2001
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  46. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2007
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  47. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  48. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2005
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  49. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2006
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  50. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2004
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  51. Nutiritional and Biochemical/Genetic Markers of Cancer
    Jing Ma; Fiscal Year: 2003
    ..Hence, the proposed project is highly cost-efficient. ..
  52. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..
  53. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2004
    ..Hence, the proposed project is highly cost-efficient. ..
  54. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2005
    ..Hence, the proposed project is highly cost-efficient. ..
  55. Nutiritional and Biochemical/Genetic Markers of Cancer
    Jing Ma; Fiscal Year: 2006
    ..Hence, the proposed project is highly cost-efficient. ..
  56. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 1991
    ..A new method for identifying endogenous ligands for such proteins is needed. Such method is being developed for this purposed...
  57. A NOVEL VITAMIN B6 METABOLITE IN HEPATOMAS
    GEORGE TRYFIATES; Fiscal Year: 1980
    ..The proposed studies may well show a new vitamin B6 metabolic pathway in tumor cells which may be mediated by an as yet unknown enzyme protein which would be characterized...
  58. VITAMIN B-6 AND STERIOD HORMONE ACTION
    JOHN CIDLOWSKI; Fiscal Year: 1991
    ....
  59. REACTION SPECIFICITY OF PYRIDOXAL PHOSPHATE ENZYMES
    MICHAEL TONEY; Fiscal Year: 2009
    ..Our studies will provide the fundamental knowledge required to target these enzymes highly specifically with small molecule drugs. ..
  60. REACTION SPECIFICITY OF PYRIDOXAL PHOSPHATE ENZYMES
    MICHAEL TONEY; Fiscal Year: 2011
    ..Our studies will provide the fundamental knowledge required to target these enzymes highly specifically with small molecule drugs. ..
  61. VITAMIN B-6 AND STERIOD HORMONE ACTION
    JOHN CIDLOWSKI; Fiscal Year: 1990
    ....
  62. REACTION SPECIFICITY OF PYRIDOXAL PHOSPHATE ENZYMES
    MICHAEL TONEY; Fiscal Year: 2010
    ..Our studies will provide the fundamental knowledge required to target these enzymes highly specifically with small molecule drugs. ..
  63. Diet, DNA Repair Genes and Breast Cancer Risk
    ARCHANA MCELIGOT; Fiscal Year: 2005
    ..Additionally, the findings of this study will provide directions for future epigenetic investigations, and targeted cancer prevention strategies. ..
  64. Diet, DNA Repair Genes and Breast Cancer Risk
    ARCHANA MCELIGOT; Fiscal Year: 2006
    ..Additionally, the findings of this study will provide directions for future epigenetic investigations, and targeted cancer prevention strategies. ..
  65. Diet, DNA Repair Genes and Breast Cancer Risk
    ARCHANA MCELIGOT; Fiscal Year: 2007
    ..Additionally, the findings of this study will provide directions for future epigenetic investigations, and targeted cancer prevention strategies. ..
  66. RELATION OF DIET TO SERUM HOMOCYSTEINE LEVEL IN YOUTHS
    Stavroula Osganian; Fiscal Year: 2001
    ..African Americans vs. Hispanics. Information generated by this study will be valuable for designing specific dietary interventions for youth and targeting subgroups of children who may be at higher risk for CVD. ..
  67. RELATION OF DIET TO SERUM HOMOCYSTEINE LEVEL IN YOUTHS
    Stavroula Osganian; Fiscal Year: 2001
    ..African Americans vs. Hispanics. Information generated by this study will be valuable for designing specific dietary interventions for youth and targeting subgroups of children who may be at higher risk for CVD. ..
  68. RELATION OF DIET TO SERUM HOMOCYSTEINE LEVEL IN YOUTHS
    Stavroula Osganian; Fiscal Year: 2000
    ..African Americans vs. Hispanics. Information generated by this study will be valuable for designing specific dietary interventions for youth and targeting subgroups of children who may be at higher risk for CVD. ..
  69. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2006
    ..The public health implications of this study are in its contributions to preventing common kidney stone disease, and preventing kidney failure in an orphan disease, Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  70. BIOSYNTHESIS OF MICROBIAL NATURAL PRODUCTS
    DAVID CANE; Fiscal Year: 1993
    ..The PCR products will be inserted into suitable E. coli expression vectors and the resulting overexpressed proteins will be used by Prof. Spenser and his collaborators to examine the formation of pyridoxol...
  71. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2002
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  72. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2000
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  73. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2003
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  74. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2007
    ..The public health implications of this study are in its contributions to preventing common kidney stone disease, and preventing kidney failure in an orphan disease, Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  75. PERTURBATIONS IN VITAMIN B6 METABOLISM IN CANCER
    LOUISE NUTTER; Fiscal Year: 2000
    ....