amprolium

Summary

Summary: Veterinary coccidiostat that interferes with thiamine metabolism. It may cause thiamine deficiency.

Top Publications

  1. ncbi Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. I: Hexamita salmonis
    J L Tojo
    Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain
    Dis Aquat Organ 33:51-6. 1998
  2. ncbi Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo
    F Athanassopoulou
    Laboratory of Ichthyology and Fish Pathology, University of Thessaly, Faculty of Veterinary Medicine, School of Health Sciences, 221 Trikalon Street, 431 00 Karditsa, Greece
    Dis Aquat Organ 62:217-26. 2004
  3. doi Comparative therapeutic effect of toltrazuril, sulphadimidine and amprolium on Eimeria bovis and Eimeria zuernii given at different times following infection in buffalo calves (Bubalus bubalis)
    Mohamed M Ghanem
    Animal Medicine Department, College of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt
    Prev Vet Med 84:161-70. 2008
  4. doi Determination of amprolium in feed by a liquid chromatography-mass spectrometry method
    S Squadrone
    C Re A A National Reference Center for the Surveillance and Monitoring of Animal feed, c o Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, 10154 Torino, Italy
    J Pharm Biomed Anal 48:1457-61. 2008
  5. ncbi Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin
    T Rathinam
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Avian Dis 53:405-8. 2009
  6. doi Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells
    D Bizon-Zygmanska
    Department of Laboratory Medicine, Medical University of Gdansk, 80 211 Gdansk, Poland
    Neurochem Int 59:208-16. 2011
  7. ncbi Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats
    G Rindi
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Pavia, Italy
    Metab Brain Dis 18:245-63. 2003
  8. ncbi Changes in weight gain, faecal oocyst count and packed cell volume of Eimeria tenella-infected broilers treated with a wild mushroom (Ganoderma lucidum) aqueous extract
    A O Ogbe
    Federal College of Animal Health and Production Technology, National Veterinary Research Institute, Vom, Nigeria
    J S Afr Vet Assoc 80:97-102. 2009
  9. doi Tissue responses of Clarias gariepinus (Catfish) to experimental Eimeria subepithelialis infection
    M I Ahmed
    Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, P O Box 8050, University of Maiduguri, Maiduguri, Nigeria
    Vet Parasitol 171:181-4. 2010
  10. ncbi QSAR study of anticoccidial activity for diverse chemical compounds: prediction and experimental assay of trans-2-(2-nitrovinyl)furan
    Humberto Gonzalez-Diaz
    Department of Organic Chemistry and Institute of Industrial Pharmacy, Faculty of Pharmacy, University of Santiago de Compostela, Santiago 15782, Spain
    Bioorg Med Chem 15:962-8. 2007

Scientific Experts

Detail Information

Publications76

  1. ncbi Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. I: Hexamita salmonis
    J L Tojo
    Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain
    Dis Aquat Organ 33:51-6. 1998
    ..The remaining non-nitroimidazoles tested (amprolium, bithionol, febantel, flubendazole, levamisole, netobimin, niclosamide, nitroxynil, oxibendazole, parbendazole, ..
  2. ncbi Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo
    F Athanassopoulou
    Laboratory of Ichthyology and Fish Pathology, University of Thessaly, Faculty of Veterinary Medicine, School of Health Sciences, 221 Trikalon Street, 431 00 Karditsa, Greece
    Dis Aquat Organ 62:217-26. 2004
    ..Initially, 6 different doses of Fumagillin, 2 doses of Toltrazuril, and 1 dose of Amprolium, ESB3 and Salinomycin were tested...
  3. doi Comparative therapeutic effect of toltrazuril, sulphadimidine and amprolium on Eimeria bovis and Eimeria zuernii given at different times following infection in buffalo calves (Bubalus bubalis)
    Mohamed M Ghanem
    Animal Medicine Department, College of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt
    Prev Vet Med 84:161-70. 2008
    We compared the therapeutic effect of three anticoccidial drugs (toltrazuril, sulphadimidine and amprolium) in buffalo (Bubalus bubalis) calves experimentally infected with Eimeria bovis (E. bovis) and E...
  4. doi Determination of amprolium in feed by a liquid chromatography-mass spectrometry method
    S Squadrone
    C Re A A National Reference Center for the Surveillance and Monitoring of Animal feed, c o Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, 10154 Torino, Italy
    J Pharm Biomed Anal 48:1457-61. 2008
    ..of the finding of veterinarian drugs in food European Community banned several compounds like coccidiostats as amprolium (APL). This antibiotic has been used as a preventive and clinical anticoccidial drug in chicken...
  5. ncbi Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin
    T Rathinam
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Avian Dis 53:405-8. 2009
    The sensitivity of field isolates of turkey coccidia from the United States to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin was investigated...
  6. doi Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells
    D Bizon-Zygmanska
    Department of Laboratory Medicine, Medical University of Gdansk, 80 211 Gdansk, Poland
    Neurochem Int 59:208-16. 2011
    ..Therefore, the aim of our work was to find out how amprolium-induced thiamine pyrophosphate deficits (TD) affect distribution of acetyl-CoA in the compartment of pure ..
  7. ncbi Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats
    G Rindi
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Pavia, Italy
    Metab Brain Dis 18:245-63. 2003
    Thiamine (T) analogues pyrithiamine, oxythiamine or amprolium in amounts 10-1000 times higher than labelled T, were i.p. injected into rats together with 14C-T (30 microg; 46.25 KBq)...
  8. ncbi Changes in weight gain, faecal oocyst count and packed cell volume of Eimeria tenella-infected broilers treated with a wild mushroom (Ganoderma lucidum) aqueous extract
    A O Ogbe
    Federal College of Animal Health and Production Technology, National Veterinary Research Institute, Vom, Nigeria
    J S Afr Vet Assoc 80:97-102. 2009
    ..At 7 weeks the birds in group A were treated with G. lucidum aqueous extract and those in B with amprolium in drinking water ad libitum at the rate of 200 mg/ml each for 7 days consecutively...
  9. doi Tissue responses of Clarias gariepinus (Catfish) to experimental Eimeria subepithelialis infection
    M I Ahmed
    Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, P O Box 8050, University of Maiduguri, Maiduguri, Nigeria
    Vet Parasitol 171:181-4. 2010
    ..At the onset of demonstrable oocysts in liver and spleen tissues, groups B and C were treated for a week in Amprolium(R) dip (0.6 mg/L) at the rate of 1 h a day...
  10. ncbi QSAR study of anticoccidial activity for diverse chemical compounds: prediction and experimental assay of trans-2-(2-nitrovinyl)furan
    Humberto Gonzalez-Diaz
    Department of Organic Chemistry and Institute of Industrial Pharmacy, Faculty of Pharmacy, University of Santiago de Compostela, Santiago 15782, Spain
    Bioorg Med Chem 15:962-8. 2007
    ..It is notable that lesion control was 72.86% at mg/kg of body weight with respect to 60% at 125 mg/kg for amprolium (control drug)...
  11. ncbi Biosynthesis and uptake of thiamine (vitamin B1) in bloodstream form Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity
    Sabine A Stoffel
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
    Int J Parasitol 36:229-36. 2006
    ..significant uptake of [3H]thiamine and structural thiamine analogues such as pyrithiamine, oxithiamine and amprolium were not toxic for the bloodstream forms of T...
  12. ncbi [New drugs for horses and production animals in 2012]
    I U Emmerich
    Dr Ilka Ute Emmerich, VETIDATA, Institut fur Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinische Fakultät der Universität Leipzig, An den Tierkliniken 39, 04103 Leipzig, E mail
    Tierarztl Prax Ausg G Grosstiere Nutztiere 41:247-52. 2013
    ..established veterinary active pharmaceutical ingredient is applicable to additional species: The anticoccidial Amprolium (Eimeryl®) has again been authorized for chicken and turkeys...
  13. ncbi Characteristics of thiamine uptake by the BeWo human trophoblast cell line
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Biochem Mol Biol 39:383-93. 2006
    ..pH decreased); 3) Na(+)-dependent and Cl(-)-independent; 4) not inhibited by the thiamine structural analogs amprolium, oxythiamine and thiamine pyrophosphate; 5) inhibited by the unrelated organic cations guanidine, N-..
  14. doi Sericea lespdeza as an aid in the control of Emeria spp. in lambs
    J M Burke
    United States Department of Agriculture, Agricultural Research Service, Booneville, AR 72927, USA
    Vet Parasitol 193:39-46. 2013
    ..assigned in a 2×2 factorial design to receive 2% of BW/d of alfalfa pellets (control) or SL with or without amprolium added to drinking water (n=38/level or 19/treatment)...
  15. doi Field amplified sample injection-capillary zone electrophoresis for the analysis of amprolium in eggs
    Anna Martínez-Villalba
    Department of Analytical Chemistry, University of Barcelona, Barcelona, Spain
    Electrophoresis 34:870-6. 2013
    ..b>Amprolium is a quaternary ammonium compound used in the treatment of coccidiosis...
  16. pmc Thiamine deficiency induces endoplasmic reticulum stress in neurons
    X Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Neuroscience 144:1045-56. 2007
    ..To establish an in vitro model of TD in neurons, we treated cultured cerebellar granule neurons (CGNs) with amprolium, a potent inhibitor of thiamine transport...
  17. ncbi Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge
    James W Carpenter
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66505, USA
    J Zoo Wildl Med 36:391-400. 2005
    The anticoccidial efficacy of amprolium, clazuril, and monensin were studied in sandhill cranes (Grus canadensis) infected with a mixture of Eimeria spp. oocysts...
  18. ncbi Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae)
    K Molnar
    Veterinary Medical Research Institute, Hungarian Academy of Sciences, H 1581 Budapest, P O Box 18, Hungary
    Acta Vet Hung 55:67-76. 2007
    ..The anticoccidial drugs (amprolium, narasin, maduramicin, salinomycin Na, lasalocid Na, diclazuril, robenidine HCl, monensin Na and toltrazuril), ..
  19. ncbi Eimeria macusaniensis infection in 15 llamas and 34 alpacas
    Christopher K Cebra
    Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4802, USA
    J Am Vet Med Assoc 230:94-100. 2007
    ..Nineteen of the camelids were admitted dead, and 30 were admitted alive. Camelids admitted alive accounted for 5.5% of all camelid admissions during this period...
  20. pmc Evaluation of a Bacillus stearothermophilus tube test as a screening tool for anticoccidial residues in poultry
    Anakalo Shitandi
    Guidford Institute, Microbiology Laboratory, Egerton University Njoro, Njoro 20107, Kenya
    J Vet Sci 7:177-80. 2006
    ..in detecting the residue of selected anticoccidial drugs in poultry, specially sulfamethazine, furazolidone, and amprolium. Various concentrations of each drug were injected into chicken liver and kidney tissues and these tissues were ..
  21. ncbi Antiparasitic and immunomodulatory effect of innovative treatments against Myxobolus sp. infection in Diplodus puntazzo
    E Karagouni
    Laboratory of Cellular Immunology, Department of Microbiology, Institut Pasteur Hellenique, 127 Vas Sofias Ave, 115 21 Athens, Greece
    Vet Parasitol 134:215-28. 2005
    ..the renal interstitial tissue, were treated by oral administration of a combination of salinomycin with amprolium, Origanum essential oil or fumagillin in a small-scale field trial...
  22. ncbi Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds
    John M Bowen
    College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7371, USA
    Vet Parasitol 134:183-8. 2005
    ..Effects on motility in culture appeared to be lethal. The following compounds lacked effects: amprolium, 2-amino-2-thiazoline, bithionol, bitoscanate, bitriben, hexachlorophene, ivermectin, and 10 H-phenothiazine...
  23. pmc A degenerative encephalomyelopathy in 7 Kuvasz puppies
    Murray J Hazlett
    Animal Health Laboratory, University of Guelph, Guelph, Ontario
    Can Vet J 46:429-32. 2005
    ..Lesions seen were felt to be familial or due to the effects of an amprolium-induced thiamine deficiency on the developing brains of these puppies.
  24. ncbi Further studies on the spectrophotometric determination of amprolium
    David W Fink
    Merial Ltd, 631 US Route 1 South, North Brunswick, NJ 08902, USA
    J AOAC Int 87:677-80. 2004
    The official AOAC spectrophotometric analytical method for amprolium in feeds (961.24) is quantitatively selective for the intact drug in the presence of its primary degradation products...
  25. ncbi Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells
    Sergiy Chornyy
    Department of Coenzyme Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Acta Biochim Pol 54:315-22. 2007
    ..presence of NGF into neurons undergo apoptosis due to thiamine deficiency caused by antagonists of thiamine - amprolium, pyrithiamine and oxythiamine...
  26. ncbi Determination of amprolium, carbadox, monensin, and tylosin in surface water by liquid chromatography/tandem mass spectrometry
    Wenlu Song
    Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824, USA
    Rapid Commun Mass Spectrom 21:1944-50. 2007
    ..This study attempts to develop a protocol to determine four commonly used veterinary pharmaceuticals, amprolium, carbadox, monensin, and tylosin, in surface runoff from a livestock farm...
  27. doi Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe
    Christian Vogl
    Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
    J Biol Chem 283:7379-89. 2008
    ..The uptake of thiamine was reduced in the presence of pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine, indicating that these compounds are substrates of Thi9...
  28. ncbi Drug resistance evaluation of some commonly used anti-coccidial drugs in broiler chickens
    M A Harfoush
    Animal Health Research Institute, Kafr El Sheikh Regional Laboratory, Egypt
    J Egypt Soc Parasitol 40:337-48. 2010
    ..Treatment decreased the harmful effect of infection but some significant differences were between infected treated groups and non infected non-treated one...
  29. doi Efficient hydrophilic interaction liquid chromatography-tandem mass spectrometry for the multiclass analysis of veterinary drugs in chicken muscle
    Chayada Chiaochan
    Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai, Bangkok 10330, Thailand
    Anal Chim Acta 682:117-29. 2010
    ..aminoglycosides, 3 β-lactams, 2 lincosamides, 4 macrolides, 4 quinolones, 4 sulfonamides, 3 tetracyclines, and amprolium) in chicken muscle...
  30. ncbi Selected veterinary pharmaceuticals in agricultural water and soil from land application of animal manure
    Wenlu Song
    Dep of Crop and Soil Sciences, Michigan State Univ, East Lansing, MI 48824, USA
    J Environ Qual 39:1211-7. 2010
    ..In this study, we investigated the occurrence and fate of four commonly used veterinary pharmaceuticals (amprolium, carbadox, monensin, and tylosin) in a farm in Michigan...
  31. doi Anticoccidial activity of the methanolic extract of Musa paradisiaca root in chickens
    George Nnamdi Anosa
    Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
    Trop Anim Health Prod 43:245-8. 2011
    ..w.) of the extract or amprolium (conventional drug). Two groups (an infected and uninfected group) did not receive treatment...
  32. doi Forty years of monensin for the control of coccidiosis in poultry
    H D Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville, USA
    Poult Sci 89:1788-801. 2010
    ..At that time, prospects for new anticoccidial agents were not good. Amprolium had enjoyed several years of use, but many other compounds had been abandoned as resistance to them developed...
  33. ncbi [Coccidiosis in lambs: observations in the preventive use of an amprolium-containing medicated feed]
    P Talmon
    Centraal Diergeneeskundig Instituut, Lelystad
    Tijdschr Diergeneeskd 114:611-7. 1989
    The efficacy of preventive in-feed medication with amprolium (2000 ppm) was studied on a farm where clinical coccidiosis in unweaned lambs at pasture has been a problem for the past seven years...
  34. ncbi Relevance and treatment of coccidiosis in domestic pigeons (Columba livia forma domestica) with particular emphasis on toltrazuril
    Maria Elisabeth Krautwald-Junghanns
    Clinic for Birds and Reptiles, An den Tierkliniken 17, 04103 Leipzig, Germany
    J Avian Med Surg 23:1-5. 2009
    ..Chemotherapeutic options discussed include amprolium, sulfonamides, clazuril, and toltrazuril...
  35. doi Assessment of antimicrobial usage and residues in commercial chicken eggs from smallholder poultry keepers in Morogoro municipality, Tanzania
    H E Nonga
    Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania
    Zoonoses Public Health 57:339-44. 2010
    ..The common drugs were oxytetracycline (75%), egg booster (50%), amprolium (35%), sulphamethoxypyridazine (35%), sulphanilamide (25%), chlortetracyclines (10%), chloramphenicol (10%), ..
  36. pmc Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase
    Zun Ji Ke
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Alcohol Clin Exp Res 33:1097-103. 2009
    ..PKR can also be activated by cellular stresses...
  37. ncbi Comparative characteristic of thiamine antagonists on apoptosis induction in different types of nerve cell lines
    S A Chornyy
    Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv
    Ukr Biokhim Zh 80:76-84. 2008
    ..of various types of nerve cells to thiamine (vitamin B) antagonists--oxythiamine (OT), pyrithiamine (PT) and amprolium (Am) was investigated...
  38. doi Anticoccidial effects of Ageratum conyzoides
    N E Nweze
    Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
    J Ethnopharmacol 122:6-9. 2009
    ..Group C received Amprolium in drinking water as 0.012 and 0.006% solutions for 7 days, respectively...
  39. ncbi Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss
    Andrew P Shinn
    Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, United Kingdom
    Dis Aquat Organ 55:17-22. 2003
    ..Trial doses of 104 ppm amprolium hydrochloride or 65 ppm clopidol fed to fish for 10 d prior to infection significantly reduced the number of ..
  40. ncbi Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells
    Hamid M Said
    Department of Medicine and Physiology, VA Medical Center, Long Beach, CA 90822 5201, USA
    Biochim Biophys Acta 1567:106-12. 2002
    ..7+/-1.6 microM, (5) inhibited by the thiamin structural analogues oxythiamin and amprolium but not by the unrelated organic cations tetraethylammonium (TEA) and N-methylnicotinamide (NMN), and (6) ..
  41. ncbi Effect of amprolium on production, sporulation, and infectivity of Eimeria oocysts
    M D Ruff
    Protozoan Diseases Laboratory, Agriculture Research Center East, Beltsville, Maryland 20705
    Avian Dis 37:988-92. 1993
    b>Amprolium reduced the number of oocysts shed by Eimeria acervulina, E. maxima, E. necatrix, and a mixture of susceptible strains of E. tenella...
  42. ncbi Biochemical and pathological findings on sheep and calves dying of experimental cerebrocortical necrosis
    R Horino
    National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 56:481-5. 1994
    ..and morphopathological changes in experimental cerebrocortical necrosis, 6 sheep and 6 calves were given amprolium (600 mg/kg/day)...
  43. ncbi Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors
    L Bettendorff
    Laboratory of Neurochemistry, University of Liege, Belgium
    J Neurochem 64:2013-21. 1995
    ..Respiration and ATP levels were only slightly affected, but addition of a thiamine transport inhibitor (amprolium) decreased ATP content and increased lactate production...
  44. ncbi Thiamin and derivatives as modulators of rat brain chloride channels
    L Bettendorff
    Laboratory of General and Comparative Biochemistry, University of Liege, Belgium
    Neuroscience 52:1009-17. 1993
    ..5 mM. Thiamin and amprolium were less effective as inhibitors. 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid (0...
  45. ncbi Determination of amprolium in egg yolk and muscle tissue (chicken) by HPLC with post-column reaction and fluorometric detection, using on-line sample clean-up and pre-concentration steps
    W Van Leeuwen
    Food Inspection Service, Utrecht, The Netherlands
    Z Lebensm Unters Forsch 186:500-4. 1988
    ..a high-pressure liquid chromatography (HPLC) system, resulting in an automated system for the determination of amprolium in egg yolk and (chicken) muscle tissue...
  46. ncbi Ion-pair reverse-phase liquid chromatographic determination of amprolium in complete feeds and premixes
    E J Kentzer
    Purdue University, Department of Biochemistry, West Lafayette, IN 47907
    J Assoc Off Anal Chem 71:251-5. 1988
    b>Amprolium is extracted with methanol-water (2 + 1) containing 5mM dioctylsulfosuccinate (DOSS) and 10mM CaCl2...
  47. ncbi [Amprolium residues in eggs following administration of amprolium/ethopabate in laying hens and breeding hens]
    C A Kan
    Centrum voor Onderzoek en Voorlichting voor de Pluimveehouderij, Het Spelderholt, Beekbergen
    Tijdschr Diergeneeskd 114:76-82. 1989
    b>Amprolium may be used as a coccidiostat in rearing hens and is a therapeutical agent used in laying hens. As a result of cross contamination, low amprolium levels may occur in feed...
  48. ncbi The ultrastructural effect of amprolium medication on development of Eimeria adenoeides in turkeys
    H D Danforth
    USDA ARS, Livestock and Poultry Sciences Institute, Beltsville Agricultural Research Center East, Maryland 20705
    Avian Dis 33:303-9. 1989
    ..0125% amprolium-medicated feed...
  49. ncbi Eimeria tenella, E. acervulina and E. maxima: studies on the development of resistance to diclazuril and other anticoccidial drugs in the chicken
    H D Chapman
    Institute for Animal Health, Houghton Laboratory, Huntingdon, Cambridgeshire
    Parasitology 99:189-92. 1989
    ..tenella in medicated chickens but resistance to amprolium was only partial after 10 passages. The pathogenicity of diclazuril- and amprolium-resistant lines of E...
  50. ncbi Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken
    H D Chapman
    Institute for Animal Health, Houghton Laboratory, Huntingdon, Cambridgeshire
    Res Vet Sci 47:125-8. 1989
    ..All were sensitive to robenidine, 28 were sensitive to methyl benzoquate, 25 to clopidol and 21 to nicarbazin. Most isolates were resistant or partly resistant to amprolium and dinitolmide.
  51. ncbi Supplemental use of liquid amprolium in skip-a-day feeding of replacement pullets
    M D Ruff
    Protozoan Diseases Laboratory, Livestock and Poultry Sciences Institute, USDA, Agricultural Research Service, Beltsville Agricultural Research Center East, Maryland 20705
    Poult Sci 70:515-20. 1991
    The addition of liquid amprolium to the drinking water on days when medicated (amprolium) ration was not fed in a restricted feeding (skip-a-day) program improved protection against a primary exposure to Eimeria acervulina and Eimeria ..
  52. ncbi Efficacy of different anticoccidials against experimental coccidiosis in large white turkeys
    M C Cabel
    Department of Animal and Poultry Sciences, University of Arkansas, Fayetteville 72701
    Poult Sci 70:289-92. 1991
    ..Diets were supplemented with either amprolium (AMP, 125 mg/kg), butynorate (BUT, 375 mg/kg), monensin (MON-60, 60 mg/kg; MON-100, 100 mg/kg), halofuginone (..
  53. ncbi Effects of different coccidiostats on performance of large white turkeys
    M C Cabel
    Department of Animal and Poultry Science, University of Arkansas, Fayetteville 72701
    Poult Sci 70:241-9. 1991
    ..Anticoccidials evaluated in the first trial included amprolium at 187...
  54. ncbi Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts
    A Arakawa
    Department of Veterinary Science, College of Agriculture, University of Osaka Prefecture, Japan
    Vet Parasitol 38:55-60. 1991
    ..Monensin, salinomycin, lasalocid, amprolium plus ethpabate, amporolium plus ethopabate plus sulfaquinoxaline, clopidol, or nicarbazin were given to chickens ..
  55. ncbi Influence of virginiamycin on growth and efficiency of large white turkeys
    P E Waibel
    Department of Animal Science, University of Minnesota, St Paul 55108
    Poult Sci 70:837-47. 1991
    Efficacy of virginiamycin (22 mg/kg) in combination with no drug, amprolium, carbarsone, halofuginone, or monensin, was studied. Male and female turkeys were raised to market age in five experiments conducted from 1983 to 1987...
  56. ncbi Effect of subclinical Eimeria species infections in tropical goats subsequently challenged with caprine Haemonchus contortus
    W A Rahman
    School of Biological Sciences, University of Science, Penang, Malaysia
    Vet Rec 134:235-7. 1994
    ..The first group was superinfected with 500,000 Eimeria species oocysts and the second group was treated with amprolium. Sixty days later both groups were infected with 5000 third-stage caprine Haemonchus contortus larvae...
  57. ncbi Effect of subclinical coccidiosis in kids on subsequent trichostrongylid infection after weaning
    C de la Fuente
    Departamento Patologia Animal I, Facultad de Veterainaria, Universidad Complutense, Madrid, Spain
    Vet Parasitol 45:177-83. 1993
    ..with a multispecific Eimeria inoculum (300,000 oocysts) or treated to control the coccidial infection with Amprolium (50 mg kg-1 liveweight day-1; 4 days every 14 days); 80 days later both animal groups received 2500 third-stage ..
  58. ncbi Effects of increasing photoperiod length and anticoccidials on performance and health of roaster chickens
    C Riddell
    Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, Saskatchewan, Canada
    Avian Dis 36:491-8. 1992
    ..The anticoccidials compared were monensin and amprolium/ethopabate, from 0 to 35 days of age...
  59. ncbi Simplified high-performance liquid chromatographic determination of residual amprolium in edible chicken tissues
    N Furusawa
    Graduate School of Human Life Science, Osaka City University, Osaka, Japan
    J Chromatogr Sci 40:355-8. 2002
    A simplified determining method for the routine monitoring of residual amprolium in edible chicken tissues (muscle and liver) is developed using a high-performance liquid chromatographic (HPLC) method with a photodiode-array detector ..
  60. ncbi Simplified high-performance liquid chromatographic determination of residual amprolium in edible chicken tissues
    N Furusawa
    Graduate School of Human Life Science, Osaka City University, Osaka, Japan
    J Chromatogr Sci 40:355-8. 2002
    A simplified determining method for the routine monitoring of residual amprolium in edible chicken tissues (muscle and liver) is developed using a high-performance liquid chromatographic (HPLC) method with a photodiode-array detector ..
  61. ncbi Comparison of ion-pairing and ion-suppressing liquid chromatographic methods for the determination of pyrimethamine and ormetoprim in chicken feed
    Shih Yuh Lin
    National Institute for Animal Health, Council of Agriculture, Tansui, Taipei, Taiwan
    J Chromatogr Sci 40:331-6. 2002
    ..Sulfamonomethoxine, sulfadimethoxine, sulfaquinoxaline, trimethoprim, amprolium, clopidol, and nicarbazin do not interfere with the detection of PYR or OMT...
  62. ncbi Determination of lignocaine and amprolium in pharmaceutical formulations using AAS
    W F El-Hawary
    Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
    J Pharm Biomed Anal 27:97-105. 2002
    ..Cl) with ammonium reineckate (Rk) or sodium cobaltithiocyanate, and that of amprolium hydrochloride (Amp.Cl) with ammonium reineckate, have been prepared...
  63. ncbi Determination of halofuginone and amprolium in chicken muscle and egg by liquid chromatography
    Y Yamamoto
    Miyazaki University, Faculty of Agriculture, Department of Veterinary Public Health, Gakuenkibanadai nishi, Japan
    J AOAC Int 84:43-6. 2001
    A liquid chromatographic (LC) method was developed for simultaneous measurement of halofuginone (HFN) and amprolium (APL) in chicken muscle and egg. HFN and APL were extracted from chicken muscle and egg with acetonitrile...
  64. ncbi Eimeria infections in litter-based, high stocking density systems for loose-housed laying hens in Sweden
    A Lunden
    Department of Parasitology, Swedish University of Agricultural Sciences SLU and National Veterinary Institute, Uppsala
    Br Poult Sci 41:440-7. 2000
    ..to increase their chance to develop immunity against coccidia, was not found to decrease the risk of coccidiosis during the production period when compared to the practice of giving amprolium and ethopabate during the rearing period.
  65. ncbi Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture
    L C Park
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York 10605, USA
    J Neurochem 74:114-24. 2000
    ..and BV-2 microglial cell lines, were cultured in either thiamine-depleted media or in normal culture media with amprolium, a thiamine transport inhibitor...
  66. ncbi Transport of thiamine in human intestine: mechanism and regulation in intestinal epithelial cell model Caco-2
    H M Said
    Veterans Affairs Medical Center, Long Beach, California, 90822, USA
    Am J Physiol 277:C645-51. 1999
    ..37 +/- 0.94 pmol. mg protein(-1). 3 min(-1); 5) inhibited by the thiamine structural analogs amprolium and oxythiamine, but not by unrelated organic cations tetraethylammonium, N-methylnicotinamide, and choline; and ..
  67. ncbi High performance liquid chromatographic assay of amprolium and ethopabate in chicken feed using solid-phase extraction
    H S Tan
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati Medical Center, OH 45267 0004, USA
    J Pharm Biomed Anal 15:259-65. 1996
    A method for the assay of mixtures of amprolium and ethopabate in chicken feed was developed utilizing reversed-phase high-performance liquid chromatography (HPLC) after sample clean-up of a methanolic extract by solid-phase extraction ..
  68. ncbi Oral pharmacological treatments for parasitic diseases of rainbow trout oncorhynchus mykiss. III. Ichthyobodo necator
    J L Tojo
    Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain
    Dis Aquat Organ 33:195-9. 1998
    ..The majority of the drugs tested (1,3-di-6-quinolylurea, aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, dimetridazole, diminazene aceturate, febantel, ..
  69. ncbi Kinetic behaviour of sulphaquinoxaline and amprolium in chickens
    M G El-Sayed
    Pharmacology Department, Fac of Vet Med Moshtohor, Benha
    Dtsch Tierarztl Wochenschr 102:481-5. 1995
    The pharmacokinetics of sulphaquinoxaline and amprolium hydrochloride were studied in Hubbard broiler chickens. Single doses of sulphaquinoxaline (100 mg/kg b. wt.), and amprolium hydrochloride (30 mg/kg b. wt...
  70. ncbi Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. II. Gyrodactylus sp
    J L Tojo
    Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain
    Dis Aquat Organ 33:187-93. 1998
    ..Twenty-two of the drugs tested (aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, flubendazole, levamisole, mebendazole, metronidazole, ..
  71. ncbi The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model
    P R Dodd
    Clinical Research Laboratory, Royal Brisbane Hospital Research Foundation, Australia
    Metab Brain Dis 11:39-54. 1996
    ..Alterations in these indices of GABA- and glutamate-mediated neurotransmission may underlie the neurological signs of acute thiamine deficiency in these animals...
  72. ncbi Biochemical and pathological observations on sheep showing various clinical manifestations of experimental cerebrocortical necrosis
    R Horino
    National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 56:573-6. 1994
    ..changes of biochemical and pathological aspects in experimental cerebrocortical necrosis, 14 sheep were given amprolium (600 mg/kg/day), and killed at various clinical stages...
  73. ncbi The impact of a successful anti-myxosporean treatment on the phagocyte functions of juvenile and adult Sparus aurata L
    E Karagouni
    Laboratory of Cellular Immunology, Institute Pasteur Hellenique, Athens, Greece
    Int J Immunopathol Pharmacol 18:121-32. 2005
    ..The infected fish were treated orally with the combination of salinomycin and amprolium, two drugs well known for their anti-coccidial effect in other animals...
  74. ncbi Response of 21 Canadian field isolates of chicken coccidia to commercial anticoccidial drugs
    A Rotibi
    Department of Poultry Science, University of Georgia, Athens 30602
    Avian Dis 33:365-7. 1989
    ..On the basis of weight gain after infection, 3 isolates were judged sensitive to amprolium, 5 to monensin, 9 to salinomycin, 14 to lasalocid, 19 to halofuginone, and 20 to nicarbazin...
  75. ncbi Chemotherapy of caecal coccidiosis: efficacy of toltrazuril, sulphaquinoxaline/pyrimethamine and amprolium/ethopabate, given in drinking water, against field isolates of Eimeria tenella
    H D Chapman
    Institute for Animal Health, Houghton Laboratory, Huntingdon, Cambridgeshire
    Res Vet Sci 46:419-20. 1989
    Treatment with toltrazuril, sulphaquinoxaline/pyrimethamine and amprolium/ethopabate prevented mortality in chickens infected with field isolates of Eimeria tenella...
  76. ncbi Polioencephalomalacia induced with amprolium in buffalo calves: pathologic changes of the central nervous system
    R K Tanwar
    Department of Veterinary Medicine, College of Veterinary Sciences, Haryana Agricultural University, Hisar, India
    Zentralbl Veterinarmed A 40:58-66. 1993
    Eight apparently healthy male buffalo calves of 6 to 12 months of age were drenched with amprolium (300 mg/kg body weight) till the development of clinical signs...

Research Grants44

  1. HUMAN INTESTINAL ANION EXCHANGERS: FUNCTION & REGULATION
    Pradeep Dudeja; Fiscal Year: 2007
    ..g. diarrheal and inflammatory diseases. ..
  2. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
    ....
  3. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..This should be of great value in future investigations into the mechanisms and regulation of transport of water-soluble vitamins in the intestine (and other tissues) at the integrated whole animal level in vivo. ..
  4. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2007
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  5. Human Intestinal Biotin Uptake:Molecular /Cell Mechanisms
    HAMID SAID; Fiscal Year: 2007
    ..This should ultimately assist us in the design of effective strategies to optimize biotin body homeostasis in conditions associated with biotin deficiency and sub-optimal levels. ..
  6. Modulation of NHE Activity by EPEC Infection
    Pradeep Dudeja; Fiscal Year: 2006
    ..Our findings may aid in the future development of improved therapeutic modalities for infectious diarrhea. ..
  7. Intestinal Biotin Absorption: Physiological, Cellular and Molecular Aspects
    Hamid M Said; Fiscal Year: 2010
    ..Results of these investigations should help in the designing of effective strategies to optimize biotin body levels, especially in conditions associated with biotin deficiency and sub-optimal levels. 1 ..
  8. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2010
    ....
  9. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    Hamid M Said; Fiscal Year: 2010
    ....
  10. HUMAN INTESTINAL ANION EXCHANGERS: FUNCTION & REGULATION
    Pradeep K Dudeja; Fiscal Year: 2010
    ..g. diarrhea! and inflammatory diseases. ..
  11. Human Intestinal Biotin Uptake: Molecular/Cell Mechanisms
    HAMID SAID; Fiscal Year: 2009
    ..This should ultimately assist us in the design of effective strategies to optimize biotin body homeostasis in conditions associated with biotin deficiency and sub-optimal levels. ..
  12. Probiotics:Potential Therapeutic Roles in Diarrhea
    Pradeep Dudeja; Fiscal Year: 2009
    ....
  13. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    HAMID SAID; Fiscal Year: 2009
    ....
  14. HUMAN INTESTINAL ANION EXCHANGERS--FUNCTION/REGULATION
    Pradeep Dudeja; Fiscal Year: 2000
    ....
  15. CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1
    HAMID SAID; Fiscal Year: 2003
    ..abstract_text> ..
  16. HUMAN INTESTINAL ANION EXCHANGERS: FUNCTION & REGULATION
    Pradeep Dudeja; Fiscal Year: 2005
    ....
  17. INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATION
    HAMID SAID; Fiscal Year: 2004
    ..These results should also contribute toward our understanding of regulation of SMVT function in other tissues that have been shown to express this transport system. ..