pheniramine

Summary

Summary: One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.

Top Publications

  1. ncbi Pre-treatment of anaphylaxis, does it really work?
    A Derbent
    Eur J Anaesthesiol 22:955-6. 2005
  2. doi Simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
    M R Louhaichi
    Laboratoire National de Contrôle des Médicaments, 11 bis Rue Jebel Lakhdar Bab Saadoun, 1006 Tunis, Tunisie
    Talanta 78:991-7. 2009
  3. ncbi Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine
    Viera Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia
    Neuro Endocrinol Lett 27:141-3. 2006
  4. ncbi Antiradical effects of antihistamines in human blood. Structure-activity relationship
    V Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Inflamm Res 55:S85-6. 2006
  5. ncbi A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model
    Jack V Greiner
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 27:568-77. 2005
  6. ncbi Life-threatening facial edema due to pine caterpillar mimicking an allergic event
    A Inal
    Cukurova University Faculty of Medicine, Division of Pediatric Allergy and Immunology, Adana, Turkey
    Allergol Immunopathol (Madr) 34:171-3. 2006
  7. ncbi Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs
    J M Yanni
    Ophthalmic Products Research, Alcon Laboratories Inc, Fort Worth, Tex 76134 2099, USA
    Arch Ophthalmol 117:643-7. 1999
  8. ncbi Conjunctival allergen challenge: models in the investigation of ocular allergy
    Mark B Abelson
    Ophthalmic Research Associates, 863 Turnpike Street, North Andover, MA 01845, USA
    Curr Allergy Asthma Rep 3:363-8. 2003
  9. pmc Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual case
    G Paul
    Critical Care Team, Dyanand Medical College and Hospital, Ludhiana, India
    Indian J Crit Care Med 13:221-3. 2009
  10. ncbi Chemical profile of counterfeit buprenorphine vials seized in Tehran, Iran
    Kambiz Soltaninejad
    Forensic Sci Int 172:e4-5. 2007

Scientific Experts

Detail Information

Publications81

  1. ncbi Pre-treatment of anaphylaxis, does it really work?
    A Derbent
    Eur J Anaesthesiol 22:955-6. 2005
  2. doi Simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
    M R Louhaichi
    Laboratoire National de Contrôle des Médicaments, 11 bis Rue Jebel Lakhdar Bab Saadoun, 1006 Tunis, Tunisie
    Talanta 78:991-7. 2009
    ..chromatographic method has been developed and validated for the simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold pharmaceuticals...
  3. ncbi Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine
    Viera Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia
    Neuro Endocrinol Lett 27:141-3. 2006
    ..Separate analysis of extra- and intracellular activity of antioxidative drugs is thus of particular importance...
  4. ncbi Antiradical effects of antihistamines in human blood. Structure-activity relationship
    V Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Inflamm Res 55:S85-6. 2006
  5. ncbi A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model
    Jack V Greiner
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 27:568-77. 2005
    ..Two treatment options currently indicated for acute ocular allergic reaction are pheniramine maleate 0.3%/naphazoline hydrochloride 0...
  6. ncbi Life-threatening facial edema due to pine caterpillar mimicking an allergic event
    A Inal
    Cukurova University Faculty of Medicine, Division of Pediatric Allergy and Immunology, Adana, Turkey
    Allergol Immunopathol (Madr) 34:171-3. 2006
    ..We report a pediatric case of severe orofacial edema mimicking an allergic reaction after ingestion of a pine processionary caterpillar; urgent airway intubation was required...
  7. ncbi Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs
    J M Yanni
    Ophthalmic Products Research, Alcon Laboratories Inc, Fort Worth, Tex 76134 2099, USA
    Arch Ophthalmol 117:643-7. 1999
    ..To evaluate the effects of topical ocular drugs with histamine H1-antagonist activity on histamine-stimulated phosphatidylinositol turnover and interleukin (IL) 6 and IL-8 secretion from human conjunctival epithelial cells...
  8. ncbi Conjunctival allergen challenge: models in the investigation of ocular allergy
    Mark B Abelson
    Ophthalmic Research Associates, 863 Turnpike Street, North Andover, MA 01845, USA
    Curr Allergy Asthma Rep 3:363-8. 2003
    Recently, the number of agents to treat ocular allergy has increased dramatically, from three (pheniramine, antazoline, cromolyn) to more than a dozen...
  9. pmc Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual case
    G Paul
    Critical Care Team, Dyanand Medical College and Hospital, Ludhiana, India
    Indian J Crit Care Med 13:221-3. 2009
    ..We report a case of a suicide attempt in a young male, where ingestion of antihistamine pheniramine maleate was complicated by nontraumatic rhabdomyolysis and oliguric acute renal failure...
  10. ncbi Chemical profile of counterfeit buprenorphine vials seized in Tehran, Iran
    Kambiz Soltaninejad
    Forensic Sci Int 172:e4-5. 2007
    ..high performance liquid chromatography (HPLC) demonstrates the presence of diacetylmorphine, acetylcodeine and pheniramine, as well as the absence of buprenorphine...
  11. ncbi Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate
    Ann Van Eeckhaut
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Belgium
    J Chromatogr A 958:291-7. 2002
    ..The assay was validated for linearity (2-10 microg/ml; R2 = 0.9992), selectivity [(RS)-pheniramine maleate and (RS)-brompheniramine maleate], limit of detection (0.25 microg/ml), limit of quantification (0...
  12. doi Mycobacterium massiliense outbreak after intramuscular injection, South Korea
    H J Kim
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Epidemiol Infect 140:1880-7. 2012
    ..e. injection with pheniramine [adjusted odds ratios (aOR) 5·93, 95% confidence interval (CI) 2·97-11·87] and ribostamycin (aOR 47·95, 95% ..
  13. doi Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK
    Theodore A Pasquali
    Durrie Vision, Overland Park, KS 66211, USA
    J Refract Surg 29:469-75. 2013
    ..To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or surgical enhancements...
  14. doi Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model
    Orhan Gokalp
    Department of Cardiovascular Surgery, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey
    Vasc Endovascular Surg 47:219-24. 2013
    The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats.
  15. doi A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus
    Rajeev B Ahuja
    Department of Burns, Plastic, Maxillofacial and Microvascular Surgery, Lok Nayak Hospital and Associated Maulana Azad Medical College, New Delhi 110 002, India
    Burns 39:24-9. 2013
    ..The four arms were: pregabalin, cetirizine with pheniramine maleate, combination of pregabalin, cetirizine and pheniramine maleate, and placebo (vit. B comp.)...
  16. pmc Effect of pheniramine maleate on reperfusion injury in brain tissue
    Ismail Yurekli
    Department of Cardiovascular Surgery, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
    Med Sci Monit Basic Res 19:285-90. 2013
    ..investigate the protective effects of methylprednisolone (Pn), which is a potent anti-inflammatory agent, and pheniramine maleate (Ph), which is an antihistaminic with some anti-inflammatory effects, on reperfusion injury in brain ..
  17. ncbi Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs
    W Neuhaus
    Department of Medicinal Chemistry, University of Vienna, Austria
    Pharmazie 67:432-9. 2012
    ..Subsequent drug transport studies with the first generation antihistamines promethazine, diphenhydramine and pheniramine and the second generation antihistamines astemizole, ceterizine, fexofenadine and loratadine were accomplished ..
  18. ncbi Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures
    M Gil-Agusti
    Area de Quimica Analitica, Universitat Jaume I 12080 Castelló, Spain
    Analyst 126:457-64. 2001
    ..phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, ..
  19. pmc C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma
    Ana B Guimaraes-Correa
    Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo UNIFESP EPM, São Paulo 04023 062, Brazil
    Viruses 3:1041-58. 2011
    ..C7a inhibited more than 60% of the ex vivo spontaneous proliferation of PBMC from HTLV-1-infected individuals. These results support a potential therapeutic role for C7a in both ATLL and HTLV-1-negative T-cell lymphomas...
  20. ncbi Uniformly sized molecularly imprinted polymers for d-chlorpheniramine: influence of a porogen on their morphology and enantioselectivity
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Biomed Anal 46:877-81. 2008
    ..a result, they showed the similar retentive and enantioselective properties for chlorpheniramine, brompheniramine and pheniramine. This result suggests the presence of enantioselective binding sites in the swollen state for all the MIPs.
  21. ncbi Enantioselective analysis of pheniramine in urine by charged CD-mediated CZE provided with a fiber-based DAD and an on-line sample pretreatment by capillary ITP
    Jozef Marák
    Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    Electrophoresis 28:2738-47. 2007
    ..with capillary ITP and DAD to the identification and determination of trace concentration levels (microg/L) of pheniramine (PHM) enantiomers and their metabolites present in complex ionic matrices of biological origin (urine) are ..
  22. ncbi First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005
    Ahmet Sen
    Department of Aerospace Medicine, Gulhane Military Medical Academy, Eskisehir, Turkey
    Aviat Space Environ Med 78:514-22. 2007
    ..Such side effects could impair performance and, thus, could be the cause or a factor in accidents. Therefore, the prevalence of these antagonists was evaluated in aviation accident pilot fatalities...
  23. ncbi Intraoperative anaphylaxis with a complicated pulmonary hydatid cyst
    Anjolie Chhabra
    Paediatr Anaesth 17:195-7. 2007
  24. doi A presentation of longstanding toxoplasmosis chorioretinitis
    Brian R Hall
    Woodhull Medical and Mental Health Center Eye Clinic, New York, New York 11206, USA
    Optometry 80:23-8. 2009
    ..Toxoplasmosis gondii is the most common cause of focal necrotizing retinitis in healthy individuals. This case report describes a presentation of toxoplasmosis chorioretintis and reviews the current management options...
  25. ncbi Goat ureter - an alternative model for measuring ureteral peristalsis
    Karpate Smita
    Department of Pharmacology, Mahatma Gandhi Institute of Medical Science, Sewagram, India
    J Smooth Muscle Res 42:117-30. 2006
    ..512 microM and 13.024 microM, but was blocked completely by 10.4 microM of pheniramine (P>0.05). The reflex was not blocked by the H2 blocker ranitidine (P<0.001)...
  26. ncbi Biological and biochemical properties of Scatophagus argus venom
    Gisha Sivan
    Department of Marine Biology, Cochin University of Science and Technology, Microbiology and Biochemistry, Foreshore Road, Kochi 682006, Kerala, India
    Toxicon 50:563-71. 2007
    ..The injection of venom in mice produced lesions and nociception, which were not inhibited by antihistamine pheniramine maleate, suggesting that histamine was not involved in the inflammatory process...
  27. ncbi Possibilities of column coupling electrophoresis provided with a fiber-based diode array detection in enantioselective analysis of drugs in pharmaceutical and clinical samples
    Peter Mikus
    Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University, Odbojarov 10, Bratislava, Slovak Republic
    J Chromatogr A 1179:9-16. 2008
    ..ionizable chiral selector and diode array detection (DAD) for the enantioselective analysis of trace drugs (pheniramine and its analogs) in pharmaceutical and clinical samples...
  28. ncbi Chiral separation of alkylamine antihistamines in pharmaceuticals by capillary isotachophoresis with charged cyclodextrin
    Peter Kubacák
    Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University, Odbojárov, Slovak Republic
    Drug Dev Ind Pharm 33:1199-204. 2007
    ..separation was developed for the separation and quantitation of alkylamine antihistamine dimethindene (DIM) and pheniramine (PHM) enantiomers in various pharmaceutical preparations (capsules, oral drops, gel, granulated powder)...
  29. ncbi Artificial neural network combined with principal component analysis for resolution of complex pharmaceutical formulations
    Giuseppina Ioele
    Department of Pharmaceutical Sciences, University of Calabria, Rende, Italy
    Chem Pharm Bull (Tokyo) 59:35-40. 2011
    ..for the multicomponent determination of caffeine (CAF), mepyramine (MEP), phenylpropanolamine (PPA) and pheniramine (PNA) in their pharmaceutical preparations without any chemical separation...
  30. doi Telephone management of severe wasp stings in rural Nepal: a case report
    Tshering Lama
    Room H005, School of Health, Community and Education Studies, Northumbria University, Coach Lane Campus East, Newcastle upon Tyne NE7 7XA, UK
    J Telemed Telecare 17:105-8. 2011
    ..This case illustrates the potential for telephone-delivered rural care and management in emergency situations...
  31. ncbi Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists
    Trivendra Tripathi
    Department of Biochemistry, Faculty of Medicine, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, India
    Pharmacol Rep 62:917-25. 2010
    ..i.d.), H1R agonist (HTMT, 10 μg/kg x b.i.d.), H2R agonist (amthamine, 10 μg/kg x b.i.d.), H1R antagonist (pheniramine, 10 mg/kg x b.i.d.) or H2R antagonist (ranitidine, 10 mg/kg x b.i.d.)...
  32. pmc Preparation and evaluation of orodispersible tablets of pheniramine maleate by effervescent method
    P V Swamy
    Department of Pharmaceutics, H K E Society s College of Pharmacy, Sedam Road, Gulbarga 585 105, India
    Indian J Pharm Sci 71:151-4. 2009
    In the present work, orodispersible tablets of pheniramine maleate were designed with a view to enhance patient compliance by effervescent method...
  33. ncbi H1-antihistamines and oxidative burst of professional phagocytes
    Radomir Nosal
    Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia
    Neuro Endocrinol Lett 30:133-6. 2009
    ..We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level of isolated and stimulated human polymorphonuclear leukocytes...
  34. doi Pouch colon associated with anorectal malformations fails to show spontaneous contractions but responds to acetylcholine and histamine in vitro
    Preeti Tyagi
    Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India
    J Pediatr Surg 44:2156-62. 2009
    ..The present article deals with the contractile study and histopathologic observations in CPC, which may be useful for better surgical management...
  35. pmc Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection
    Ho Jun Lee
    Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:879-82. 2009
    ..5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected...
  36. doi Halogenation effects of pheniramines on the complexation with beta-cyclodextrin
    Li Fen Wang
    Department of Applied Chemistry and Material Science, Fooyin University, Kaohsiung 831, Taiwan, ROC
    J Pharm Biomed Anal 50:392-6. 2009
    This study investigated the inclusion complexes of beta-cyclodextrin with pheniramine and its halogenated derivatives chlorpheniramine and brompheniramine both experimentally and theoretically to characterize the effects of a halogenated ..
  37. doi Comparison of chiral separation of basic drugs in capillary electrophoresis and liquid chromatography using neutral and negatively charged cyclodextrins
    Arkadiusz Kwaterczak
    Institute of Physical Chemistry PAS, Kasprzaka 44 52, 01 224 Warsaw, Poland
    Anal Chim Acta 645:98-104. 2009
    ..The enantiomeric separation of basic chiral pharmaceuticals such as pheniramine, brompheniramine, metoxyphenamine, cyclopentolate, doxylamine and ketamine was investigated in capillary ..
  38. doi A study of the functional aberration of the pouch in anorectal malformation associated with congenital pouch colon
    A N Gangopadhyay
    Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U P India
    Colorectal Dis 12:226-31. 2010
    ..There is no consensus regarding the utilization of the CPC in repair of anorectal malformation. In view of the above, it was decided to carry out detailed in vitro physiological study of the excised CPC...
  39. doi The lollipop with strawberry aroma may be promising in reduction of infusion-related nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells
    Evren Ozdemir
    Hacettepe University Institute of Oncology, Stem Cell Transplantation Unit, Ankara, Turkey
    Biol Blood Marrow Transplant 14:1425-8. 2008
    ..Before infusion, all patients were premedicated with pheniramine maleate 45.5 mg i.v. and paracetamol 500 mg orally...
  40. ncbi [Toxic epidermal necrolysis following dorzolamide eyedrops]
    V M Asensio-Sánchez
    An Med Interna 25:47-8. 2008
  41. ncbi Evaluation of a new premedication protocol for administration of equine rabies immunoglobulin in patients with hypersensitivity
    M K Sudarshan
    Principal and Professor of Community Medicine, Community Medicine, Kempegowda Institute of Medical Sciences, Bangalore
    Indian J Public Health 51:91-6. 2007
    ..The present study was undertaken to standardize skin testing and to develop a safe and effective premedication protocol for administration of ERIG in those with skin test positivity/hypersensitivity...
  42. ncbi Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene
    Hiroshi Hasegawa
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:14404-14. 2007
    ..Functionally, we found that the regenerative axon growth of Advillin-null sensory neurons is significantly shortened and that deletion of Advillin reduces the plasticity of whisker-related barrelettes patterns in the hindbrain...
  43. doi Spinal anesthesia with diphenhydramine and pheniramine in rats
    Ching Hsia Hung
    Institute and Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan
    Eur J Pharmacol 673:20-4. 2011
    The aim of this study was to evaluate the local anesthetic effects of pheniramine and diphenhydramine, two histamine H₁ receptor antagonists, on spinal anesthesia and their comparison with lidocaine, a commonly used local anesthetic...
  44. ncbi A case of pheniramine dependence
    Omer Saatcioglu
    Bakirkoy Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey
    Subst Abus 26:45-7. 2005
    ..The withdrawal signs may become after using drugs such as L-histidine, histamine-N-methyl, promethazine, pheniramine, astemizole, etc...
  45. ncbi Enantioselective determination of pheniramine in pharmaceuticals by capillary electrophoresis with charged cyclodextrin
    Peter Mikus
    Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University, Odbojarov 10, SK 83232 Bratislava, Slovak Republic
    J Pharm Biomed Anal 38:442-8. 2005
    ..CZE) in hydrodynamically closed separation system was developed for the separation and quantitation of pheniramine (PHM) enantiomers...
  46. ncbi Auditory evoked potentials in young patients with Down syndrome. Event-related potentials (P3) and histaminergic system
    R Seidl
    Department of Pediatrics, University Hospital Vienna, Austria
    Brain Res Cogn Brain Res 5:301-9. 1997
    ..ERPs were recorded from 12 healthy adults (aged 20-28 years) before and after antihistaminergic intervention (pheniramine) compared to placebo...
  47. ncbi Alkylamine antihistamine toxicity and review of Pediatric Toxicology Registry of the National Association of Medical Examiners. Report 4: Alkylamines
    M I Jumbelic
    Onondaga County Medical Examiner s Office, Syracuse, New York 13202, USA
    Am J Forensic Med Pathol 18:65-9. 1997
    ..4 mg/L and greater in children is indicative of brompheniramine poisoning. However, pheniramine was also present in the blood in the same case and may have caused an additive effect...
  48. ncbi The role of histamine H1-receptors in the anticonvulsive effect of morphine against maximal electroconvulsive shock in mice
    C H Karadag
    Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Jpn J Pharmacol 71:109-12. 1996
    ..1 mg/kg, i.p.) promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p...
  49. ncbi Regulation of vascular permeability by macrophage-derived chemotactic factor produced in Japanese encephalitis
    N Khanna
    Postgraduate Department of Microbiology, K G s Medical College, Lucknow, India
    Immunol Cell Biol 72:200-4. 1994
    ....
  50. ncbi [Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures]
    F R Schulze
    Institut fur Pharmazie, Freie Universitat Berlin
    Arch Pharm (Weinheim) 327:455-62. 1994
    ..Nevertheless substances with a pheniramine like partial structure proved to be potent histamine H2-receptor antagonists at the atrium model (about 27 ..
  51. ncbi Pheniramine--a much abused drug
    N A Buckley
    Department of Clinical Pharmacology and Toxicology, Newcastle Mater Misericordiae Hospital, Waratah, NSW
    Med J Aust 160:188-92. 1994
    To assess the relative clinical toxicity of pheniramine compared with other antihistamines taken in overdose and its relative use for self-poisoning.
  52. ncbi Mydriatic effect of ocular decongestants studied by pupillography
    C Gelmi
    Department of Ophthalmology, University of Pavia, Italy
    Ophthalmologica 208:243-6. 1994
    ..3% chlorpheniramine maleate, and 0.05% tetrahydrozoline hydrochloride in combination with 0.3% pheniramine maleate, respectively, was evaluated in 10 healthy volunteers...
  53. ncbi A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy
    A Thomas
    Central Leprosy Teaching and Research Institute, Chengalpattu
    Indian J Lepr 60:499-505. 1988
    ..were randomly allocated to a regimen of clofazimine and dapsone for 12 months with or without a supplement of pheniramine maleate for the first 3 months...
  54. ncbi Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs
    A Buschauer
    Institute of Pharmacy, Freie Universitat Berlin, Federal Republic of Germany
    J Med Chem 32:1963-70. 1989
    ..yl)methyl]thio]ethyl]guanidine) by more lipophilic H2-nonspecific pheniramine-like structures resulted in potent H2 agonists with up to 160 times the activity of histamine in the isolated, ..
  55. ncbi [Sudden infant death--fatal poisoning with pheniramine]
    S Ogbuihi
    Institut fur Rechtsmedizin, Westfalische Wilhelms Universitat, Bundesrepublik Deutschland
    Z Rechtsmed 103:221-5. 1990
    A case of unintentional fatal intoxication of a 10 month-old baby with the anti-histamine Pheniramine (Avil) is reported...
  56. ncbi Solubilization of salicylamide and acetaminophen by antihistamines in aqueous solution
    S P Shah
    Searle Research and Development, Stokie, IL 60077
    J Pharm Sci 79:889-92. 1990
    The effect of self-association of the antihistaminic drugs pheniramine, chlorpheniramine, and brompheniramine as their maleate salts on the solubilization of salicylamide and acetaminophen in aqueous solution has been investigated...
  57. ncbi Therapeutic value of H2-receptor stimulation in congestive heart failure. Hemodynamic effects of BU-E-76, BU-E-75 and arpromidine (BU-E-50) in comparison to impromidine
    S B Felix
    I Medical Clinic, Division Cardiology and Circulation, Technical University of Munich, FRG
    Agents Actions Suppl 33:257-69. 1991
    ..BU-E-75 and BU-E-76, all guanidine-type H2-agonists with additional H1-antagonistic properties due to a pheniramine like moiety...
  58. ncbi Role of histaminergic mechanisms in the regulation of some stress responses in rats
    S Puri
    Department of Pharmacology, University College of Medical Sciences, Delhi, India
    Pharmacol Biochem Behav 39:847-50. 1991
    ..alpha-FMH also appreciably reduced gastric mucosal HA content. The H1-antagonist, pheniramine (25 mg/kg), attenuated both the gastric mucosal and endocrine response to CRS, while the effects of the H2-..
  59. ncbi Breakdown of the blood-brain barrier during dengue virus infection of mice
    U C Chaturvedi
    Postgraduate Department of Microbiology, King George s Medical College, Lucknow, India
    J Gen Virol 72:859-66. 1991
    ..These findings show a breakdown of the blood-brain barrier leading to cerebral oedema during DEN2 infection which is mediated via the release of histamine by a virus-induced cytokine...
  60. ncbi Treatment of chronic idiopathic urticaria with topical preparations: controlled study of oxatomide gel versus dechlorpheniramine cream
    F Locci
    Medical Pathology II, Cagliari Polyclinic, Italy
    Drugs Exp Clin Res 17:399-403. 1991
    ..01 between times). During the follow-up period, a distinct flare-up of symptoms was observed only in the dechlorpheniramine group. Acceptability and safety, both clinical and biological, were good for both products...
  61. ncbi Biphasic effect of histamine on spontaneously beating rat atria
    I Cakici
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Gen Pharmacol 23:705-8. 1992
    ..5. The initial negative chronotropic phase was significantly enhanced by propranolol and reduced by pheniramine (10(-6) M). 6...
  62. ncbi Case report: unilateral mydriasis from topical Opcon-A and soft contact lens
    T L Williams
    Division of Ophthalmology, Southern Illinois University School of Medicine, SIU Eye Center, Springfield, USA
    Aviat Space Environ Med 68:1035-7. 1997
    ..Continued emphasis of the possible deleterious side effects by the clinician is recommended to circumvent these problems...
  63. ncbi Enhancement of the antimalarial effect of chloroquine by chloropheniramine in vivo
    A Sowunmi
    Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training, University of Ibadan, Nigeria
    Trop Med Int Health 3:177-83. 1998
    ..Chloroquine/chloropheniramine produces a higher cure rate than chloroquine alone and reverses chloroquine insensitivity in Plasmodium falciparum in vivo. It may be a useful way of optimising the antimalarial effect of chloroquine...
  64. ncbi [Use of capillary isotachophoresis for the determination of pheniramine in granulated powders]
    P Kubacak
    Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej analýzy a nukleárnej farmácie
    Ceska Slov Farm 54:86-9. 2005
    The method of capillary isotachophoresis was used to assay pheniramine in granulated powders. Several electrolyte systems of different composition and different pH were tested...
  65. ncbi Rapid identification and quantification of chlorpheniramine maleate or pheniramine maleate in pharmaceutical preparations by thin-layer chromatography-densitometry
    Seppakkam P Subramaniyan
    Government of India, Department of Biochemistry, Central Drugs Laboratory, Kolkata 700 016, India
    J AOAC Int 87:1319-22. 2004
    ..TLC)-densitometry was used to separate, identify, and quantitate chlorpheniramine maleate (CPM) and pheniramine maleate (PM) when present in combination with other drugs in pharmaceutical preparations of tablets, syrups, ..
  66. ncbi Uniformly sized molecularly imprinted polymer for d-chlorpheniramine. Evaluation of retention and molecular recognition properties in an aqueous mobile phase
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr A 948:77-84. 2002
    ..Further, the MIP showed the highest recognition for chlorpheniramine and slight recognition for its structurally related compounds, and enantioseparation of pheniramine was attained.
  67. ncbi Efficacy and safety of rectal thiopental, intramuscular cocktail and rectal midazolam for sedation in children undergoing neuroimaging
    Handan Alp
    Department of Pediatrics, Ataturk University Faculty of Medicine, Erzurum, Turkey
    Pediatr Int 44:628-34. 2002
    ..m. modified cocktail (meperidine-chlorpromazine hydrochloride-feniramin maleat) in 70 children undergoing computed tomography (CT) and magnetic resonance imaging (MRI)...
  68. ncbi Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2)
    Zeynep Tumer
    Department of Medical Genetics, Wilhelm Johannsen Centre for Functional Genome Research, IMBG, 24 4, The Panum Institute, University of Copenhagen, Blegdamsvej 3, Denmark
    Gene 288:179-85. 2002
    ....
  69. ncbi A phase II study of paclitaxel and cisplatin combination chemotherapy in recurrent or metastatic head and neck cancer
    M Basaran
    University of Instanbul, Institute of Oncology, Medical Oncology Department, Turkey
    J Chemother 14:207-13. 2002
    ..Taxol, Bristol Myers Squibb Company, Princeton, NJ) and cisplatin therapy (PC) consisted of prophylaxis with pheniramine 50 mg i.v., ranitidine 150 mg i.v. and dexamethasone 20 mg i.v...
  70. ncbi Role of central histaminergic system in lorazepam withdrawal syndrome in rats
    C Nath
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Pharmacol Biochem Behav 68:777-82. 2001
    ..The drugs (in mg/kg administered intramuscularly)--L-histidine (50), histamine-N-methyl (2), promethazine (10), pheniramine (10), astemizole (10), and thioperamide (1)--were given separately in other groups daily during the withdrawal ..
  71. ncbi Comparison of two video-assisted techniques for the difficult intubation
    P Biro
    Department of Anaesthesiology, University Hospital, Zurich, Switzerland
    Acta Anaesthesiol Scand 45:761-5. 2001
    ....
  72. ncbi pH-independent large-volume sample stacking of positive or negative analytes in capillary electrophoresis
    N E Baryla
    Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
    Electrophoresis 22:52-8. 2001
    ..8-1.6%, 1.3-3.7%, and 0.8-4.9%, respectively. Further, it is possible to stack either positively or negatively charged analytes using zwitterionic surfactants to suppress the EOF...
  73. ncbi Application of heparin to chiral separations of antihistamines by capillary electrophoresis
    Y Jin
    Department of Chemistry, University of Cincinnati, OH 45221 0172, USA
    Electrophoresis 19:2119-23. 1998
    A study of the chiral separations of antihistamines, including pheniramine, chlorpheniramine, brompheniramine, carbinoxamine and doxylamine in capillary electrophoresis (CE) was accomplished using heparin as a chiral additive (CA) and ..
  74. ncbi Combined histamine H1/H2 receptor antagonists: part I. Pharmacological hybrids with pheniramine- and roxatidine-like substructures
    F R Schulze
    Institut fur Pharmazie, Freie Universitat Berlin, K onigin Luise Strasse 2 4, D 14195 Berlin, Germany
    Eur J Pharm Sci 6:177-86. 1998
    A series of hybrid compounds combining the pharmacophores of both pheniramine-type histamine H1 receptor antagonists and roxatidine-type H2 receptor antagonists have been synthesized and tested for histamine antagonism at the isolated ..
  75. ncbi Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures
    C Wolf
    Institut fur Pharmazie, Freie Universitat Berlin, K onigin Luise Strasse 2 4, D 14195 Berlin, Germany
    Eur J Pharm Sci 6:187-96. 1998
    Hybrid molecules combining the crucial structural features of both pheniramine-type histamine H1 receptor antagonists and guanidinothiazole-type H2 receptor antagonists have been synthesized and tested for in vitro pharmacological ..
  76. ncbi Five-minute removal of soft lenses prevents most absorption of a topical ophthalmic solution
    M T Christensen
    Alcon Laboratories, Inc, Fort Worth, TX 76134 2099, USA
    CLAO J 24:227-31. 1998
    ..This study was designed to test the hypothesis that waiting 5 minutes before reinsertion of lenses would be sufficient to reduce absorption to a level below what is needed to produce a physiological response...
  77. ncbi [Cutaneous loxoscelism with edematous predominance]
    H Schenone
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Bol Chil Parasitol 53:78-83. 1998
    ..laeta venom. In Chile, the differential diagnosis must be planted with the following clinical entities: bites of hematophagous insects on the face, bee stings, Chagas' disease with facial port of entry and angioneurotic edema...
  78. ncbi Pharmacology and quantitative structure-activity relationships of imidazolylpropylguanidines with mepyramine-like substructures as non-peptide neuropeptide Y Y1 receptor antagonists
    S Dove
    University of Regensburg, Institute of Pharmacy
    Can J Physiol Pharmacol 78:108-15. 2000
    ..Y1 antagonistic activity (inhibition of NPY-stimulated Ca2+ increase in human erythroleukemic cells), where the pheniramine-like moiety of arpromidine was replaced with 2-pyridylaminoalkyl, benzyl-(2-pyridyl)aminoalkyl, and phenyl-(2-..
  79. ncbi Central histaminergic involvement during stress in rats
    A Ray
    Department of Pharmacology, University College of Medical Sciences, Delhi, India
    Indian J Exp Biol 30:724-8. 1992
    ..c.v.) treatment. Further, the H1-blocker, pheniramine (25 mg/kg, ip) but not the centrally acting H2-blocker, zolantidine (5 mg/kg, ip) produced clearcut ..
  80. ncbi Contribution of the histaminergic receptor subtypes to histamine-induced cerebellar granular neurotoxicity
    Akcahan Gepdiremen
    Ataturk University, Faculty of Medicine, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 55:383-8. 2003
    ..b>Pheniramine (H(1) receptor blocker), ranitidine (H(2) receptor blocker) and thioperamide (H(3) receptor blocker) were ..
  81. pmc Effect of dengue virus-induced cytotoxin on capillary permeability
    R Dhawan
    Postgraduate Department of Microbiology, K G Medical College, Lucknow, India
    J Exp Pathol (Oxford) 71:83-8. 1990
    ..The findings thus show that DV-induced CF2 increases the capillary permeability via release of histamine...