nitrendipine

Summary

Summary: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Top Publications

  1. ncbi Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats
    Dengning Xia
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No 103, Wenhua Road, Shenyang 110016, China
    Pharm Res 27:1965-76. 2010
  2. ncbi Solid self-emulsifying nitrendipine pellets: preparation and in vitro/in vivo evaluation
    Zhiyuan Wang
    Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No 103 of Wenhua Road, Shenyang 110016, China
    Int J Pharm 383:1-6. 2010
  3. ncbi Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics
    Kesavan Bhaskar
    Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India
    Drug Dev Ind Pharm 35:98-113. 2009
  4. ncbi Morbidity and mortality after stroke--eprosartan compared with nitrendipine for secondary prevention: principal results of a prospective randomized controlled study (MOSES)
    Jean Martin Boulanger
    Stroke 37:335-6; author reply 338. 2006
  5. ncbi Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine
    Katarzyna A Mitręga
    Chair and Department of Pharmacology, Medical University of Silesia, Poland
    Pharmacol Res 66:300-8. 2012
  6. ncbi Preparation and evaluation of solid dispersions of nitrendipine prepared with fine silica particles using the melt-mixing method
    Liang Wang
    Department of Pharmaceutics, Shenyang Pharmaceutical University, PR China
    Chem Pharm Bull (Tokyo) 54:37-43. 2006
  7. ncbi Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability
    Dengning Xia
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No 103, Wenhua Road, Shenyang 110016, China
    Eur J Pharm Sci 40:325-34. 2010
  8. ncbi Importance of blood pressure variability in organ protection in spontaneously hypertensive rats treated with combination of nitrendipine and atenolol
    He Hui Xie
    Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
    Acta Pharmacol Sin 23:1199-204. 2002
  9. ncbi Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats
    Jian Guo Liu
    Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
    J Hypertens 21:1961-7. 2003
  10. ncbi Development of nitrendipine controlled release formulations based on SLN and NLC for topical delivery: in vitro and ex vivo characterization
    Kesavan Bhaskar
    Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India
    Drug Dev Ind Pharm 34:719-25. 2008

Research Grants

Detail Information

Publications219 found, 100 shown here

  1. ncbi Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats
    Dengning Xia
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No 103, Wenhua Road, Shenyang 110016, China
    Pharm Res 27:1965-76. 2010
    To investigate the effect of crystal size on the dissolution and oral absorption of nitrendipine, a poorly soluble drug, in rats.
  2. ncbi Solid self-emulsifying nitrendipine pellets: preparation and in vitro/in vivo evaluation
    Zhiyuan Wang
    Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No 103 of Wenhua Road, Shenyang 110016, China
    Int J Pharm 383:1-6. 2010
    Objective of this study is to develop and evaluate the new solid self-emulsifying (SE) pellets of poorly soluble nitrendipine (NTD)...
  3. ncbi Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics
    Kesavan Bhaskar
    Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India
    Drug Dev Ind Pharm 35:98-113. 2009
    ..such as solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) for transdermal delivery of nitrendipine (NDP). For this investigation, four different gel-forming agents were selected for hydrogel preparation...
  4. ncbi Morbidity and mortality after stroke--eprosartan compared with nitrendipine for secondary prevention: principal results of a prospective randomized controlled study (MOSES)
    Jean Martin Boulanger
    Stroke 37:335-6; author reply 338. 2006
  5. ncbi Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine
    Katarzyna A Mitręga
    Chair and Department of Pharmacology, Medical University of Silesia, Poland
    Pharmacol Res 66:300-8. 2012
    ..therefore decided to compare the influence of oral and intravenous administration of furnidipine, nifedipine, nitrendipine and nimodipine to examine their effects on hemodynamics and arrhythmias...
  6. ncbi Preparation and evaluation of solid dispersions of nitrendipine prepared with fine silica particles using the melt-mixing method
    Liang Wang
    Department of Pharmaceutics, Shenyang Pharmaceutical University, PR China
    Chem Pharm Bull (Tokyo) 54:37-43. 2006
    Solid dispersions (SD) of nitrendipine (NTD), a poorly water-soluble drug, were prepared using the melt-mixing method with hydrophilic silica particles (Aerosil and Sylysia) with different particle size and specific surface areas as ..
  7. ncbi Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability
    Dengning Xia
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No 103, Wenhua Road, Shenyang 110016, China
    Eur J Pharm Sci 40:325-34. 2010
    The aim of this study was to prepare and characterize nitrendipine nanosuspensions to enhance the dissolution rate and oral bioavailability of this drug. Nanosuspensions were prepared by the precipitation-ultrasonication method...
  8. ncbi Importance of blood pressure variability in organ protection in spontaneously hypertensive rats treated with combination of nitrendipine and atenolol
    He Hui Xie
    Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
    Acta Pharmacol Sin 23:1199-204. 2002
    To study the importance of reduction of blood pressure variability (BPV) in the organ protection of long-term treatment with combination of nitrendipine and atenolol, which was abbreviated as Nile, in spontaneously hypertensive rats (SHR).
  9. ncbi Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats
    Jian Guo Liu
    Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
    J Hypertens 21:1961-7. 2003
    ..The present work was designed to observe the effects of long-term treatment with nitrendipine and hydralazine on BPV and EOD in spontaneously hypertensive rats (SHR), to examine the hypothesis that ..
  10. ncbi Development of nitrendipine controlled release formulations based on SLN and NLC for topical delivery: in vitro and ex vivo characterization
    Kesavan Bhaskar
    Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India
    Drug Dev Ind Pharm 34:719-25. 2008
    ..solid lipid nanoparticles (SLN) and nano-structured lipid carrier (NLC) as carriers for topical delivery of nitrendipine (NDP)...
  11. ncbi Predicting the anti-hypertensive effect of nitrendipine from plasma concentration profiles using artificial neural networks
    A Belic
    Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    Comput Biol Med 35:892-904. 2005
    b>Nitrendipine is an effective and safe calcium-channel blocker for the treatment of mild to moderate hypertension...
  12. ncbi Development of nitrendipine transdermal patches: in vitro and ex vivo characterization
    Ramesh Gannu
    Center for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009 A P, India
    Curr Drug Deliv 4:69-76. 2007
    The aim of the investigation was to develop and evaluate matrix type transdermal drug delivery systems (TDDS) of nitrendipine (NTDP).
  13. ncbi Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration
    Kopparam Manjunath
    NDDS Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, 506 009, Andhra Pradesh, India
    J Drug Target 14:632-45. 2006
    The aim of this research was to study whether the bioavailability of nitrendipine (NDP) could be improved by administering nitrendipine solid lipid nanoparticles (SLN) duodenally to rats.
  14. ncbi Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats
    He Hui Xie
    Department of Pharmacology, Second Military Medical University, Shanghai, China
    J Hypertens 23:193-201. 2005
    This study was designed to investigate the possible synergism of atenolol and nitrendipine on blood pressure (BP) and blood pressure variability (BPV) reductions, baroreflex sensitivity (BRS) amelioration, and organ protection in ..
  15. ncbi Comparison of the antihypertensive effects of the fixed dose combination enalapril 10 mg/nitrendipine 20 mg vs losartan 50 mg/hydrochlorothiazide 12.5 mg, assessed by 24-h ambulatory blood pressure monitoring, in essential hypertensive patients
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
    J Hum Hypertens 18:215-22. 2004
    ..The aim of the present study was to compare the antihypertensive efficacy of the combination enalapril 10 mg/nitrendipine 20 mg (E/N) vs losartan 50 mg/hydrochlorothiazide 12...
  16. ncbi Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics
    Venishetty Vinay Kumar
    University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh 506009, India
    Int J Pharm 335:167-75. 2007
    b>Nitrendipine is an antihypertensive drug with poor oral bioavailability ranging from 10 to 20% due to the first pass metabolism...
  17. ncbi Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine
    Ashu Mittal
    ITS Paramedical Pharmacy College, Ghaziabad, India
    Acta Pharm 59:383-93. 2009
    The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate...
  18. ncbi Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES)
    Joachim Schrader
    Department of Internal Medicine, St Josefs Hospital, Cloppenburg, Germany
    Stroke 36:1218-26. 2005
    In hypertensive stroke patients, for the same level of blood pressure control, eprosartan will be more effective than nitrendipine in reducing cerebrovascular and cardiovascular morbidity and mortality.
  19. ncbi Does the MOSES study provide sufficient evidence for Eprosartan against Nitrendipine?
    Klaus Larsen
    Stroke 37:1357; author reply 1358. 2006
  20. ncbi Development and evaluation of nitrendipine nanoemulsion for intranasal delivery
    Ratnesh Jain
    Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai 400019, India
    J Biomed Nanotechnol 5:62-8. 2009
    The clinical efficacy of Nitrendipine (NDP), a potent antihypertensive molecule, is limited due to its low oral bioavailability (10% to 20%) resulting from its extensive first-pass metabolism...
  21. ncbi Acrylate-based transdermal therapeutic system of nitrendipine
    Dnyanesh N Tipre
    University Department of Chemical Technology, Pharmaceutical Division, University of Mumbai, Matunga, Mumbai, India
    Drug Dev Ind Pharm 29:71-8. 2003
    ..the present research investigation was to fabricate an acrylate-based transdermal therapeutic system (TTS) of nitrendipine, which could deliver drug at maximum input rate so as to deliver drug in minimum patch size...
  22. ncbi Nitrendipine and amlodipine mimic the acute effects of enalapril on renal haemodynamics and reduce glomerular hyperfiltration in patients with chronic kidney disease
    L F Morrone
    Section of Nephrology, Department of Internal Medicine and Public Medicine, University of Bari, Polyclinic, Piazza G Cesare, Bari, Italy
    J Hum Hypertens 17:487-93. 2003
    ..patients, we compared the effect on glomerular haemodynamics of two second-generation dihydropyridinic agents, nitrendipine and amlodipine, with a first generation dihydropyridinic agent and an ACE-inhibitor, enalapril...
  23. ncbi Development of ultra fast liquid chromatographic method for simultaneous determination of nitrendipine and carvone in skin diffusate samples
    Ramesh Gannu
    National Facilities in Engineering and Technology with Industrial Collaboration NAFETIC Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India
    J Pharm Biomed Anal 50:1080-4. 2009
    ..and sensitive reverse phase ultra fast liquid chromatographic (UFLC) method for simultaneous determination of nitrendipine and carvone in skin diffusate samples and microemulsions was developed and validated...
  24. ncbi Cost-utility analysis of eprosartan compared to enalapril in primary prevention and nitrendipine in secondary prevention in Europe--the HEALTH model
    Björn Schwander
    Analytica International, Lörrach, Germany
    Value Health 12:857-71. 2009
    To investigate the cost-utility of eprosartan versus enalapril (primary prevention) and versus nitrendipine (secondary prevention) on the basis of head-to-head evidence from randomized controlled trials.
  25. ncbi Moxonidine treatment of hypertensive patients with advanced renal failure
    Oliver Vonend
    Department of Nephrology of the Ruhr University Bochum at Marienhospital Herne, Germany
    J Hypertens 21:1709-17. 2003
    To compare safety and tolerability of moxonidine versus nitrendipine in hypertensive patients with renal failure...
  26. ncbi Comparison of nitrendipine and cilazapril in patients with hypertension and non-insulin-dependent diabetes mellitus
    D Giugliano
    Department of Geriatrics and Metabolic Diseases, Faculty of Medicine, Second University of Naples, Italy
    Am J Hypertens 6:927-32. 1993
    The metabolic and cardiovascular effects of nitrendipine and cilazapril in patients who have elevated blood pressure and non-insulin-dependent diabetes mellitus (NIDDM) were compared...
  27. ncbi Effects of Li+ transport and intracellular binding on Li+/Mg2+ competition in bovine chromaffin cells
    C P Fonseca
    Department of Biochemistry and Centre for Neuroscience of Coimbra, University of Coimbra, P O Box 3126, 3001 401 Coimbra, Portugal
    Biochim Biophys Acta 1691:79-90. 2004
    ..absorption (AA) spectrophotometry, in control (without and with ouabain) and depolarising (without and with nitrendipine) conditions, showed that L-type voltage-sensitive Ca(2+) channels have an important role in Li(+) uptake under ..
  28. ncbi Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial
    Jan A Staessen
    J Hypertens 22:847-57. 2004
    ....
  29. ncbi [Effects of nitrendipine on circadian variation of blood pressure in inpatients with renal parenchymal hypertension: assessment by ambulatory blood pressure monitoring]
    Terukuni Ideura
    Division of Nephrology, Showa University Fujigaoka Hospital, Kanagawa, Japan
    Nihon Jinzo Gakkai Shi 46:434-41. 2004
    To study the effect of once-daily administration of a nitrendipine tablet 10 mg on 24-hour ambulatory blood pressure in inpatients with renal parenchymal hypertension.
  30. ncbi The role of existing and newer calcium channel blockers in the treatment of hypertension
    Jan Basile
    Ralph H Johnson VA Medical Center, Division of General Internal Medicine Geriatrics, Medical University of South Carolina, 109 Bee Street, Charleston, SC 29401 5799, USA
    J Clin Hypertens (Greenwich) 6:621-29; quiz 630-1. 2004
    ....
  31. ncbi The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study
    Francoise Forette
    Department of Geriatrics, Hopital Broca, CHU Cochin, University of Paris V, 54 56 Rue Pascal, 75013 Paris, France
    Arch Intern Med 162:2046-52. 2002
    ..After the double-blind, placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial ended in February 1997, randomized patients were offered active study medication for a further period of observation...
  32. pmc Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices
    Ran Sook Woo
    Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School, Chonju 561 180, Republic of Korea
    Br J Pharmacol 137:1063-70. 2002
    ..1 micro M) but not by nitrendipine (1 micro M). 4. Tetrodotoxin (1 micro M) and nisoxetine (0...
  33. ncbi Administration time-dependent effect of nitrendipine on the reduction of cardiac hypertrophy in spontaneously hypertensive rats
    T Shiga
    Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan
    Am J Hypertens 12:1264-7. 1999
    The influence of administration time of nitrendipine on the regression of cardiac mass was studied in spontaneously hypertensive rats (SHR). Nitrendipine (100 mg/kg) was given once daily at 10 AM or 10 PM for 16 weeks...
  34. ncbi Nitrendipine blocks the nociceptive effects of chronically administered ethanol
    Michael B Gatch
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol Clin Exp Res 26:1181-7. 2002
    ..Calcium channel blockers prevent the development of tolerance to ethanol and prevent seizures and other signs of ethanol withdrawal. Calcium channels may also mediate the development of tolerance to the antinociceptive effects of ethanol...
  35. ncbi Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo
    Karen M Doyle
    Department of Pharmacology, School of Pharmacy, Trinity College, Dublin 2, Ireland
    Neurosci Lett 380:247-51. 2005
    The ability of nitrendipine, nisoldipine, verapamil and gabapentin to inhibit the development of CNS excitation induced by spermine was assessed in mice. Injection of an excitotoxic dose of spermine (100 microg, i.c.v...
  36. pmc L-type calcium channel-mediated plateau potentials in barrelette cells during structural plasticity
    Fu Sun Lo
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Neurophysiol 88:794-801. 2002
    ..Increased Ca(2+) entry may play a key role in injury-induced structural remodeling, and/or transsynaptic cell death...
  37. pmc Effect of combination therapy with a calcium channel blocker and an angiotensin-converting enzyme inhibitor on renal hypertrophy and urinary albumin excretion in diabetic rats
    Birgitte Nielsen
    Medical Research Laboratories Diabetes and Endocrinology, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark
    Exp Diabesity Res 4:191-9. 2003
    ..Treatment was commenced immediately in 1 set of rats with 4 treatment arms: nitrendipine (250 mg/kg fodder), enalapril (35 mg/L drinking water), both treatments in combination, or placebo...
  38. ncbi Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat
    Manel M Santafe
    Unitat d Histologia i Neurobiologia UHN Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, carrer St Llorenç num 21, 43201 Reus, Spain
    Eur J Neurosci 17:119-27. 2003
    ..In some experiments we previously incubated the muscle with calcium channel blockers (nitrendipine, omega-conotoxin-GVIA and omega-Agatoxin-IVA) before determining the muscarinic response...
  39. ncbi Influence of nifedipine, nitrendipine and verapamil at low concentration on antipyrine metabolism examined by extracorporeal rat liver perfusion
    Adam Szelag
    Department of Pharmacology, Medical University of Wrocław, Mikulicza Radeckiego 2, PL 50 345 Wrocław, Poland
    Pol J Pharmacol 55:203-8. 2003
    ..The present study investigated the effect of the selected CCI (nifedipine, nitrendipine and verapamil) on liver function, measured by the efficiency of oxidation reaction, in this case by ..
  40. ncbi Synaptic mechanisms regulating the activation of a Ca(2+)-mediated plateau potential in developing relay cells of the LGN
    Fu Sun Lo
    Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, Louisiana State Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    J Neurophysiol 87:1175-85. 2002
    ..These age-related changes in Ca(2+) signaling may contribute to the activity-dependent refinement of retinogeniculate connections...
  41. ncbi Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial
    J A Staessen
    , Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    S Afr Med J 91:1060-8. 2001
    ..e. nitrendipine, with the possible addition of enalapril and hydrochlorothiazide, or to matching placebos (N = 2,297)...
  42. ncbi A double-blind trial of perindopril and nitrendipine in incipient diabetic nephropathy
    D Kopf
    Department of Endocrinology and Metabolism, University of Magdeburg, Germany
    Diabetes Nutr Metab 14:245-52. 2001
    ..trial to compare the efficacy of the inhibitor of the angiotensin-converting enzyme (ACE) perindopril (P) with nitrendipine (N) in incipient diabetic nephropathy...
  43. ncbi Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment of dose-response relationship by a clinical trial of factorial design
    A Roca-Cusachs
    Hypertension Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Cardiovasc Pharmacol 38:840-9. 2001
    ..The aim of this study was to assess the dose-response relationship of nitrendipine and enalapril alone or in fixed combination in the treatment of mild to moderate hypertension...
  44. ncbi Parathyroid hormone-stimulated resorption in calvaria cultured in serum-free medium is enhanced by the calcium-mobilizing activity of 1,25-dihydroxyvitamin D(3)
    W Li
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Bone 29:231-5. 2001
    ..The effect of analog AT was faster than that of 1,25(OH)(2)D(3). Nitrendipine, a specific L-type VSCC blocker, attenuated enhancement by vitamin D compounds, indicating that the high-..
  45. ncbi Inhibition of type A GABA receptors by L-type calcium channel blockers
    P Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Neuroscience 124:195-206. 2004
    ..The dihydropyridines nifedipine and nitrendipine, and the phenylalkylamine verapamil inhibited recombinant rat alpha1beta2gamma2 receptors recorded from human ..
  46. ncbi Paradoxical release of nitric oxide by an L-type calcium channel antagonist, the R+ enantiomer of amlodipine
    Xiao ping Zhang
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    J Cardiovasc Pharmacol 39:208-14. 2002
    ..To determine whether the R+ enantiomer releases nitric oxide, the ability of amlodipine, its enantiomers, and nitrendipine to release nitric oxide in isolated coronary microvessels and to regulate cardiac tissue oxygen consumption via ..
  47. ncbi Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals
    F J Urbano
    , Facultad de Ciencias Exactas y Naturales, Universidad de Buenons Aires, Ciudad Universitaria, Argentina
    Pflugers Arch 441:824-31. 2001
    ..OA-induced increment of QC was attenuated greatly (approximately 95% reduction) by preincubation with either nitrendipine (10 microM) or calciseptine (300 nM). The effect of OA (1 microM) and pervanadate (0...
  48. ncbi Effect of amyotrophic lateral sclerosis serum on calcium channels related to spontaneous acetylcholine release
    Salomón Muchnik
    Instituto de Investigaciones Medicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Clin Neurophysiol 113:1066-71. 2002
    ..MEPP) frequency, by the mouse passive transfer model, and to study whether the transferred serum induces any change in the sensitivity of the L-type voltage-dependent calcium channels (VDCC) to its specific blocker Nitrendipine.
  49. ncbi Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension
    J G Wang
    Hypertension Division, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
    Hypertension 37:1069-74. 2001
    ..02) for cardiovascular mortality and 1.34 (1.14 to 1.57, P<0.001) for fatal stroke. In conclusion, in older Chinese patients with isolated systolic hypertension, serum creatinine and serum uric acid were predictors of mortality...
  50. ncbi [Toxicological analysis of selected 1,4-dihydropyridine calcium channel blockers in the diagnosis of intoxications]
    Roman Wachowiak
    Katedra i Zakład Medycyny Sadowej, Poznan
    Arch Med Sadowej Kryminol 55:47-54. 2005
    ..The program included analysis of nine of the most frequently prescribed derivatives: nifedipine, felodipine, amlodipine, nicardipine, nimodypine, nilvadipine, nitrendipine, nisoldipine, isradipine.
  51. ncbi Analysis of recent papers in hypertension. An angiotensin receptor blocker is more effective than a calcium channel blocker in secondary stroke prevention
    Michael J Bloch
    Division of General Internal Medicine, University of Nevada School of Medicine, Reno, NV 89503, USA
    J Clin Hypertens (Greenwich) 7:489-92. 2005
  52. ncbi BCRP transports dipyridamole and is inhibited by calcium channel blockers
    Yi Zhang
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Box 357610, Seattle, Washington 98195 7610, USA
    Pharm Res 22:2023-34. 2005
    ..We investigated whether dipyridamole and various calcium channel blockers are inhibitors and/or substrates of breast cancer resistance protein (BCRP)...
  53. ncbi Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury
    Cindy Lee
    Department of Surgery, Division of Trauma, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Trauma 59:56-63; discussion 63. 2005
    ..We hypothesized that SOCE inhibition might suppress postshock PMN activation, lessening lung injury without compromising cardiovascular performance...
  54. ncbi CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons
    Helmut Kubista
    Center for Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Neuropharmacology 52:1650-62. 2007
    ..The high potency and selectivity of CSTX-1 for a subset of L-type channels in mammalian neurons may enable the toxin to be used as a molecular tool for the investigation of this family of Ca(v) channels...
  55. ncbi [Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat]
    R Rota
    INSERM U 400, ,
    Arch Mal Coeur Vaiss 87:975-7. 1994
    ..We evaluated edema due to LA, nitrendipine (NT) and nifedipine (NF) in SHR. METHODS: Mean arterial pressure (MAP) was measured with an intra-femoral probe...
  56. ncbi Systolic blood pressure reduction with olmesartan medoxomil versus nitrendipine in elderly patients with isolated systolic hypertension
    Jean Michel Mallion
    Cardiologie et Hypertension Arterielle, Service de Cardiologie et hypertension artérielle, Hopital A Michallon CHU, BP 217 38043 Grenoble Cedex, France
    J Hypertens 25:2168-77. 2007
    ..in the elderly, and the objective of this study was to compare the antihypertensive efficacy of olmesartan medoxomil with that of nitrendipine in elderly (65-74 years) and very elderly (>/= 75 years) male and female patients with ISH.
  57. pmc Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers
    S Hanafy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Br J Pharmacol 153:90-9. 2008
    ....
  58. ncbi Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension
    P L Katzman
    Department of Endocrinology, University of Lund, , Sweden
    Horm Metab Res 19:426-9. 1987
    ..The increased insulin clearance could be expected to be coupled to a change in glucose tolerance, but this was unaltered during long-term calcium antagonism...
  59. ncbi Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury
    Cindy Lee
    Department of Surgery, Division of Trauma, New Jersey Medical School, Newark, New Jersey, USA
    Shock 30:29-35. 2008
    ..Ca2+ entry inhibition is a candidate therapy for management of lung injury after shock...
  60. ncbi Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons
    Ana R Santiago
    Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, 3004 517, Portugal
    Neurochem Res 33:1501-8. 2008
    ..Selective Ca(2+) channel blockers, namely nitrendipine, omega-Conotoxin GVIA (omega-GVIA) and omega-Agatoxin IVA (omega-AgaIVA) were used...
  61. ncbi [Hypotensive effect of a new calcium antagonist, SR 33557 in conscious rats]
    C Lacour
    Sanofi Recherche, Montpellier, France
    Arch Mal Coeur Vaiss 83:1281-4. 1990
    ..6 nM, 3H-nitrendipine)...
  62. pmc Ca(2+)-channel blockers modulate expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor genes stimulated by platelet-derived growth factor
    L H Block
    Department of Medicine, University of Freiburg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:9041-5. 1991
    The effects of Ca(2+)-channel blockers (amlodipine, nifedipine, nitrendipine, and verapamil) on expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1...
  63. ncbi Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats
    Li Lin Liu
    Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China
    Toxicology 231:81-90. 2007
    The aim of this study was to compare the roles of dihydropyridine calcium antagonists nifedipine, nitrendipine, amlodipine on doxorubicin (DXR)-induced nephrotoxicity in rats using biochemical, histopathological and immunohistochemical ..
  64. ncbi Preventing cerebrovascular and cardiovascular events after stroke: eprosartan or nitrendipine?
    S Claiborne Johnston
    Stroke Service, University of California, San Francisco, CA, USA
    Nat Clin Pract Neurol 2:24-5. 2006
  65. ncbi Sustained beta-adrenergic stimulation increased L-type Ca2+ channel expression in cultured quiescent ventricular myocytes
    Miyuki Akuzawa-Tateyama
    Department of Physiology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Physiol Sci 56:165-72. 2006
    ..stimulation, was blocked by a beta-AR antagonist, propranolol (10 microM), but not by a Ca2+ antagonist, nitrendipine (10 microM)...
  66. ncbi Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats
    Toshihiko Ishimitsu
    Department of Hypetension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Am J Hypertens 19:1233-40. 2006
    ..The objective of this study was to evaluate the effect of year-long antihypertensive therapy with a calcium channel blocker and an angiotensin-converting enzyme (ACE) inhibitor on cardiac and renal injury...
  67. ncbi Tolerance to the antinociceptive effects of ethanol during ethanol withdrawal
    Michael B Gatch
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, United States
    Prog Neuropsychopharmacol Biol Psychiatry 30:946-52. 2006
    ..Three potential pharmacological mechanisms for this tolerance are examined, using nitrendipine (L-type calcium channel blocker), theophylline (adenosine A1/A2 antagonist) and flumazenil (benzodiazepine ..
  68. ncbi Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy
    L Heinemann
    Department of Metabolic Diseases and Nutrition, , Germany
    Horm Metab Res 28:549-52. 1996
    ..5 mg bid), nitrendipine (N: 5 mg bid) and placebo (P) on 18 Type 1 normotensive (blood pressure < 140/90 mmHg) diabetic patients ..
  69. ncbi Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries
    Lise Rodat
    Universite Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, 146 rue Leo Saignat, F33076 Bordeaux, France
    Pflugers Arch 454:41-51. 2007
    ..rats in a hypobaric chamber for 3 weeks, potentiated the contraction to 5-HT and this effect was insensitive to nitrendipine. Calcium signal to 5-HT was characterized by a transient followed by a sustained phase in both normoxia and ..
  70. ncbi Determination of nifedipine in serum of women in preterm labor by high-performance liquid chromatography with diode array detection
    Dorota Kowalczuk
    Medical University of Lublin, Faculty of Pharmacy, Department of Medicinal Chemistry, 6 Chodzki Str, 20 093 Lublin, Poland
    J AOAC Int 89:71-7. 2006
    ..5 ng/mL, respectively. Validation of the method demonstrated good intraday and interday precision, which ranged from 2.18 to 6.67% and from 6.52 to 11.93%, respectively...
  71. ncbi Effects of a calcium antagonist on the pituitary-adrenal axis
    S Rocco
    Institute of Semeiotica Medica University of Padua, Italy
    Horm Metab Res 25:114-6. 1993
    ..To further investigate these aspects we tested the effects of a calcium antagonist nitrendipine on basal and oCRH-stimulated ACTH secretion, in 6 hypertensive patients, with normal hypothalamus pituitary ..
  72. ncbi [Emergency checklist in hypertensive crisis]
    H S Fuessl
    MMW Fortschr Med 148:49. 2006
  73. ncbi Interactions between grapefruit juice and cardiovascular drugs
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Am J Cardiovasc Drugs 4:281-97. 2004
    ..when hypertension is managed with the dihydropyridines felodipine, nicardipine, nifedipine, nisoldipine, or nitrendipine. An alternative agent could be amlodipine...
  74. ncbi Decreased calcium influx into the neonatal rat motor nerve terminals can recruit additional neuromuscular junctions during the synapse elimination period
    M M Santafe
    Histology and Neurobiology Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, carrer St Llorenç, num 21, 43201 Reus, Spain
    Neuroscience 110:147-54. 2002
    ..The L-type channel blocker nitrendipine (1 microM) increased the mean poly-innervation index (35.79% +/- 3.91; P<0.05)...
  75. pmc Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers
    K Lawson
    Recherche Syntex France, Leuville sur Orge, France
    Br J Pharmacol 107:58-65. 1992
    ..v.), Ro 31-6930 (1-1000 micrograms kg-1, i.v.), RP-49356 (10-1000 micrograms kg-1, i.v.) or nitrendipine (0.1-30 micrograms kg-1, i.v.) produced dose-dependent falls in diastolic blood pressure (DBP).ET-1 (i.v...
  76. pmc Investigations of the dual contractile/relaxant properties showed by antioquine in rat aorta
    M D Ivorra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Valencia, Spain
    Br J Pharmacol 109:502-9. 1993
    ..its effects on the contractile activity of rat isolated aorta, specific binding of [3H]-(+)-cis-diltiazem, [3H]-nitrendipine and [3H]-prazosin to cerebral cortical membranes and the different molecular forms of cyclic nucleotide ..
  77. ncbi Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels
    P J Pauwels
    Department of Biochemical Pharmacology, Janssen Research Foundation, Beerse, Belgium
    J Pharmacol Exp Ther 255:1117-22. 1990
    ..order of potency: nicardipine greater than gallopamil and verapamil greater than niludipine greater than nitrendipine greater than nifedipine greater than nimodipine greater than diltiazem...
  78. ncbi Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction
    S De Lorenzo
    Instituto de Investigaciones Medicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Combatientes de Malvinas 3150, 1427 Buenos Aires, Argentina
    Neuroscience 142:71-85. 2006
    ..Blockade of Ca(2+) channels by both, Cd(2+) or the combined application of nitrendipine and omega-conotoxin GVIA (omega-CgTx) (L-type and N-type Ca(2+) channel antagonists, respectively) prevented ..
  79. ncbi Inhibition by propofol of intracellular calcium mobilization in cultured mouse pituitary cells
    Jacques T Ya Deau
    Anesthesiology Division, Hospital of Special Surgery, Weill Medical College of Cornell University, New York, New York, NY 10021, USA
    Anesth Analg 97:1325-30. 2003
    ..9 microM; P < 0.05). Nitrendipine also inhibited potassium-induced Ca(2+) peaks...
  80. ncbi Influence of calcium-entry blockade on vasoconstrictor responses in feline mesenteric vascular bed
    H L Lippton
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112
    Circ Res 61:570-80. 1987
    ..Responses to phenylephrine and UK14304 were reduced by nitrendipine, a calcium-entry blocking agent, and this agent decreased vasoconstrictor responses to sympathetic nerve ..
  81. pmc Radioligand binding studies of alpha 1-adrenoceptor subtypes in rat heart
    M C Michel
    Department of Medicine, University of Essen, Germany
    Br J Pharmacol 111:533-8. 1994
    ..cerebral cortex and hippocampus but none of them displayed detectable alpha 1-adrenoceptor subtype-selectivity; nitrendipine did not compete for [3H]-prazosin binding in concentrations up to 5 mumol 1(-1). 3...
  82. pmc Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, alpha 1-adrenoceptor and benzothiazepine binding site at the calcium channel
    M D Ivorra
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Spain
    Br J Pharmacol 106:387-94. 1992
    ..of glaucine at calcium channel binding sites of alpha-adrenoceptors, by use of [3H]-(+)-cis-diltiazem, [3H]-nitrendipine and [3H]-prazosin binding to cerebral cortical membranes...
  83. ncbi The H+, K(+)-ATPase inhibitor pantoprazole (BY1023/SK&F96022) interacts less with cytochrome P450 than omeprazole and lansoprazole
    W A Simon
    Byk Gulden Pharmazeutika, Konstanz, Germany
    Biochem Pharmacol 42:347-55. 1991
    ..g. SK&F 525A, metyrapone, chlorpromazine and nitrendipine, different enzymes seem to be responsible for these three indicator reactions of the cytochrome P450IIB1 ..
  84. ncbi Formation of DNA-damaging N-nitroso compounds from the interaction of calcium-channel blockers with nitrite
    Antonietta Martelli
    Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, I 16132 Genoa, Italy
    Toxicology 238:211-5. 2007
    ..After 6h incubation the yields of NOC formed in vitro from nicardipine, nifedipine, nimodipine and nitrendipine ranged from 37 to 45% of the theoretical one, whereas the yields of NOC formed from diltiazem, gallopamil and ..
  85. pmc Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture
    G R May
    Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh
    Br J Pharmacol 114:1365-70. 1995
    ..in rat embryonic cerebrocortical neurones in primary culture has been compared with that of tetrodotoxin (TTX), nitrendipine, (+)-MK-801 and (-)-MK-801...
  86. ncbi Excitatory effect of the A2A adenosine receptor agonist CGS-21680 on spontaneous and K+-evoked acetylcholine release at the mouse neuromuscular junction
    A G Palma
    Laboratorio de Neurofisiologia, Instituto de Investigaciones Medicas Alfredo Lanari, Universidad de Buenos Aires, CONICET, Combatientes de Malvinas 3150, 1427 Buenos Aires, Argentina
    Neuroscience 172:164-76. 2011
    ..channel (VDCC) blocker ω-Agatoxin IVA, but it was completely prevented by both, the L-type VDCC blocker nitrendipine (which is known to immobilize their gating charges), or thapsigargin, suggesting that the effects of CGS-21680 ..
  87. pmc Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines
    S Chulia
    Departamento de Farmacologia, Facultad de Farmacia, Universitat de Valencia, Spain
    Br J Pharmacol 113:1377-85. 1994
    ..Its effects on [3H]-(+)-cis-diltiazem and [3H]-nitrendipine binding to rat cerebral cortical membranes, and on the different molecular forms of cyclic nucleotide ..
  88. pmc Modulation of dopamine and noradrenaline release and of intracellular Ca2+ concentration by presynaptic glutamate receptors in hippocampus
    J O Malva
    Department of Zoology, University of Coimbra, Portugal
    Br J Pharmacol 113:1439-47. 1994
    ..In contrast, the increase in [Ca2+]i due to stimulation by glutamate was not sensitive to CNQX or MK-801.5. Nitrendipine, at I JAM, did not inhibit the neurotransmitter release induced by AMPA, but, both 0...
  89. ncbi Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells
    Haoping Mao
    Tianjin University of Traditional Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300 193, China
    J Ethnopharmacol 125:59-67. 2009
    ..Salvia miltiorrhiza (Danshen) is a well known traditional Chinese herb, which has been used widely in China for the treatment of cardiovascular diseases in clinic...
  90. ncbi Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists
    Rachel W S Li
    Department of Pharmacology, The University of Hong Kong, Hong Kong
    Eur J Pharmacol 568:75-82. 2007
    ..be the most potent inhibitor of hENT-1, with an IC(50) value of 60+/-31 muM, whereas nifedipine, nicardipine, nitrendipine, and felodipine exhibited 100-fold less effective inhibitory activity...
  91. ncbi Effects of antihypertensive drug treatment on the risk of dementia and cognitive impairment
    Ivy O Poon
    College of Pharmacy and Health Sciences, Texas Southern University, and the Michael E DeBakey VA Medical Center, Houston, Texas 77004, USA
    Pharmacotherapy 28:366-75. 2008
    ..The Syst-Eur study found that active treatment with nitrendipine, enalapril, and/or hydrochlorothiazide reduced the rate of dementia by 50% compared with placebo (p=0.05)...
  92. ncbi Interactions between calcium channel blockers and alpha-adrenoceptors in the human coronary and mammary arteries: a radioligand binding study
    E Bronzetti
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita La Sapienza, Roma, Italy
    J Auton Pharmacol 14:79-85. 1994
    ..whether Ca2+ channel blockers of the dihydropyridine family (felodipine, nicardipine, nifedipine, nimodipine, nitrendipine and nisoldipine), and of the phenylalkylamine family (verapamil) have any effect on alpha-adrenoceptor binding ..
  93. pmc Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat
    D R Blue
    Syntex Research, Palo Alto, CA 94304, USA
    Br J Pharmacol 115:283-94. 1995
    ..Additionally, vasoconstriction mediated by this alpha 1-adrenoceptor subtype or subtypes was abolished by nitrendipine (1 microM), thereby allowing characterization of the second, high affinity site for 5-methyl-urapidil. 3...
  94. ncbi Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats
    Masahiro Matsubara
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Sunto gun, Shizuoka 411 8731, Japan
    Eur J Pharmacol 580:201-13. 2008
    ..leukocytes more potently than other calcium channel blockers such as amlodipine, azelnidipine, nitrendipine and nifedipine...
  95. ncbi Effects of L-type Ca2+ channel antagonists on in vitro excystment of Paragonimus ohirai metacercariae induced by sodium cholate
    Teruaki Ikeda
    Department of Medical Zoology, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Parasitol Res 99:336-40. 2006
    ..b>Nitrendipine and (+/-)-verapamil inhibited CIIE by about one half and one third, respectively...
  96. ncbi Trandolapril: a newer angiotensin-converting enzyme inhibitor
    David R P Guay
    Institute for the Study of Geriatric Pharmacotherapy, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Ther 25:713-75. 2003
    ..The fixed-dose combination of trandolapril and verapamil extended release (ER) is approved for the treatment of hypertension only...
  97. ncbi Dose- and administration time-dependent effects of nifedipine gits on ambulatory blood pressure in hypertensive subjects
    Ramon C Hermida
    Bioengineering and Chronobiology Laboratories, University of Vigo, Vigo, Spain
    Chronobiol Int 24:471-93. 2007
    ..or evening dosing of several calcium channel blockers (CCB), including amlodipine, isradipine, verapamil, nitrendipine, and cilnidipine...
  98. ncbi Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels
    J O Malva
    Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Portugal
    Neurochem Int 32:7-16. 1998
    ..This increase in [Ca2+]i induced by 100 microM D-aspartate was insensitive to 1 microM nitrendipine, but was inhibited by about 50% by the presence of both 500 nM omega-CgTx GVIA and 100 nM omega-Aga IVA or by ..
  99. ncbi Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity
    J Chang
    Department of Experimental Therapeutics, Wyeth Laboratories, Inc, Philadelphia, Pennsylvania 19101
    Inflammation 11:353-64. 1987
    ..More potent or equipotent dihydropyridine calcium antagonists such as nitrendipine and felodipine did not inhibit PLA2 activity...
  100. ncbi Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell
    W S Zawalich
    Yale University School of Nursing, New Haven, Connecticut 06536 0740, USA
    J Biol Chem 272:3527-31. 1997
    ..were abolished by the K1+-ATP channel blocker diazoxide (200 microM) and by the calcium channel antagonist nitrendipine (500 nM)...
  101. ncbi Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance
    U Fuhr
    Institute for Pharmacology, Universitat zu Koln, Germany
    Drug Saf 18:251-72. 1998
    ..For felodipine, nitrendipine, nisoldipine and saquinavir, the interaction was most marked with median increases of area under the curve (AUC)..

Research Grants19

  1. CALCIUM AND CONTROL OF RENIN SECRETION
    John Fray; Fiscal Year: 1990
    ..stretch), adenosine, isoproterenol and forskolin, angiotensin II, and ADH, organic Ca-channel blockers (nitrendipine, verapamil, diltiazem, and D-600), and ANP...
  2. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
    ..be examined will include a blocker of neuronal activity (tetrodotoxin), a blocker of L-type calcium channels (nitrendipine), non-selective blockers of calcium channels (EGTA, Mg++), blocking the release of calcium from internal stores ..
  3. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1992
    ..channels (ROC) by employing Ca++ channel antagonist specific for either a VOC (verapamil, diltiazem, nitrendipine) or ROC (nitroprusside, nitroglycerin) and VOC patentiators (BAY K 8644)...
  4. ROLE OF PLASMA MEMBRANE IN STIMULUS-SECRETION COUPLING
    Margarethe Hoenig; Fiscal Year: 1991
    ..will be studied in the presence and absence of the calcium channel agonist Bay K 8644 and the antagonist nitrendipine in a perifusion system...
  5. ACTIONS OF CALCIUM AND ANTAGONISTS ON MALIGNANT CELLS
    Robert Simpson; Fiscal Year: 1990
    ..responsive to calcium possess intrinsic and measurable differences in the concentration or binding activity of nitrendipine sensitive calcium slow channels...
  6. THYROID HORMONE AND CELLULAR CALCIUM REGULATION
    Laura Kragie; Fiscal Year: 1992
    ..evidence revealing and inverse relationship of TH status and cardiac calcium channels, as demonstrated by (3H)- nitrendipine binding. These data, along with recent literature, point t TH influence upon cellular calcium regulation...
  7. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  8. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  9. Regulation of Oxidative Stress in the mdx Diaphragm
    JOHN LAWLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. Development of High Throughput Assays for N-type Calcium Channels
    Edward Perez Reyes; Fiscal Year: 2007
    ..By targeting an important protein in the pain pathway, the research funded by this grant will provide tools that can be used to screen candidate compounds during the development of novel analgesics. [unreadable] [unreadable] [unreadable]..
  11. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  12. MOLECULAR ANALYSIS OF NEURONAL T TYPE CA++ CHANNELS
    Edward Perez Reyes; Fiscal Year: 2007
    ..Lead compounds will be sent to the NIH Anticonvulsant Drug Development Program for in vivo testing. These studies will test the hypothesis that more potent channel blockers are better antiepileptics and the importance of selectivity. ..
  13. Mechanisms by which T-type calcium channels increase seizure susceptibility
    Edward Perez Reyes; Fiscal Year: 2010
    ..The studies will likely have a clinical impact: showing that T-channel antagonists reverse the effects of Cav3.2 variants on dendritic development, thereby providing the rationale for their early use to cure epilepsy. ..
  14. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  15. OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKS
    S Johnston; Fiscal Year: 2005
    ..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..
  16. Regularity Mechanisms of Aldosterone Secretion
    Wendy Bollag; Fiscal Year: 2006
    ..The complex interactions between AngII and serum K+ levels suggest that abnormalities in the glomerulosa cell response to either agonist, or both, may contribute to the development of some forms of hypertension. [unreadable] [unreadable]..
  17. Topical Treatment for Mild Psoriasis
    Wendy Bollag; Fiscal Year: 2007
    ..An effective, easy-to-use, low-cost therapy suitable for long-term relief would be a great boon. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. PHOSPHOLIPASE D AND KERATINOCYTE DIFFERENTIATION
    Wendy Bollag; Fiscal Year: 2007
    ..abstract_text> ..