nicardipine

Summary

Summary: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.

Top Publications

  1. ncbi Treatment of acute hypertension in patients with intracerebral hemorrhage using American Heart Association guidelines
    Adnan I Qureshi
    Clinical Trials Division, Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Crit Care Med 34:1975-80. 2006
  2. ncbi Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, Mannheim, Germany
    Stroke 38:330-6. 2007
  3. doi Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage
    Panayiotis N Varelas
    Department of Neurology, K 11, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Neurocrit Care 13:190-8. 2010
  4. ncbi Continuous nicardipine infusion to control blood pressure after evacuation of acute cerebral hemorrhage
    T Nishiyama
    Department of Surgical Center, The Institute of Medical Science, The University of Tokyo, Japan
    Can J Anaesth 47:1196-201. 2000
  5. ncbi Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients
    T Denolle
    Biotrial SA, rue Jean Louis Bertrand 35000 Rennes, France
    Fundam Clin Pharmacol 16:527-35. 2002
  6. doi Intraventricular nicardipine for aneurysmal subarachnoid hemorrhage related vasospasm: assessment of 90 days outcome
    Na Lu
    Clinical Research Internship Study Program, Mayo Clinic, Jacksonville, FL, USA
    Neurocrit Care 16:368-75. 2012
  7. doi Prospective randomized comparison of safety and efficacy of nicardipine and nitroprusside drip for control of hypertension in the neurosurgical intensive care unit
    Ben Z Roitberg
    Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neurosurgery 63:115-20; discussion 120-1. 2008
  8. ncbi Optimization of pH-independent release of nicardipine hydrochloride extended-release matrix tablets using response surface methodology
    Yaw Bin Huang
    School of Pharmacy, Kaohsiung Medical University, No 100, Shih Chuan 1st Rd, Kaohsiung City 80708, Taiwan, ROC
    Int J Pharm 289:87-95. 2005
  9. ncbi Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients
    Boris Krischek
    Department of Neurosurgery, Tokyo Women s Medical University
    Neurol Med Chir (Tokyo) 47:389-94; discussion 394-6. 2007
  10. ncbi Effects of nicardipine and bupivacaine on early after depolarization in rabbit sinoatrial node cells: a possible mechanism of bupivacaine-induced arrhythmias
    T Matsuda
    Department of Anesthesiology, Kanazawa Medical University, Ishikawa, Japan
    Gen Pharmacol 33:115-25. 1999

Detail Information

Publications213 found, 100 shown here

  1. ncbi Treatment of acute hypertension in patients with intracerebral hemorrhage using American Heart Association guidelines
    Adnan I Qureshi
    Clinical Trials Division, Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Crit Care Med 34:1975-80. 2006
    ....
  2. ncbi Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, Mannheim, Germany
    Stroke 38:330-6. 2007
    The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage.
  3. doi Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage
    Panayiotis N Varelas
    Department of Neurology, K 11, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Neurocrit Care 13:190-8. 2010
    To evaluate the efficacy, tolerability, and safety of nicardipine infusion in controlling the elevated blood pressure after subarachnoid hemorrhage (SAH).
  4. ncbi Continuous nicardipine infusion to control blood pressure after evacuation of acute cerebral hemorrhage
    T Nishiyama
    Department of Surgical Center, The Institute of Medical Science, The University of Tokyo, Japan
    Can J Anaesth 47:1196-201. 2000
    To explore the long-term effects of the calcium antagonist, nicardipine, on cerebral hemodynamics in patients with acute cerebral hemorrhage, we investigated the effects of nicardipine infusion on intracranial pressure (ICP), middle ..
  5. ncbi Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients
    T Denolle
    Biotrial SA, rue Jean Louis Bertrand 35000 Rennes, France
    Fundam Clin Pharmacol 16:527-35. 2002
    ..was to investigate the cognitive and electroencephalography (EEG) short-term effects of a calcium antagonist, nicardipine, compared to placebo and clonidine (which, having known sedative effects, acted as a negative control) for 15 ..
  6. doi Intraventricular nicardipine for aneurysmal subarachnoid hemorrhage related vasospasm: assessment of 90 days outcome
    Na Lu
    Clinical Research Internship Study Program, Mayo Clinic, Jacksonville, FL, USA
    Neurocrit Care 16:368-75. 2012
    ..We evaluated the safety of intraventricular nicardipine (IVN) for vasospasm (VSP) in aSAH patients, and outcomes compared with a control population.
  7. doi Prospective randomized comparison of safety and efficacy of nicardipine and nitroprusside drip for control of hypertension in the neurosurgical intensive care unit
    Ben Z Roitberg
    Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neurosurgery 63:115-20; discussion 120-1. 2008
    The calcium channel blocker nicardipine (NC) is effective for acute control of hypertension. However, efficacy and safety in neurosurgical patients have not been evaluated...
  8. ncbi Optimization of pH-independent release of nicardipine hydrochloride extended-release matrix tablets using response surface methodology
    Yaw Bin Huang
    School of Pharmacy, Kaohsiung Medical University, No 100, Shih Chuan 1st Rd, Kaohsiung City 80708, Taiwan, ROC
    Int J Pharm 289:87-95. 2005
    The purpose of this study was to optimize the pH-dependent release of nicardipine hydrochloride extended release formulations by using simultaneously combination two hydrophilic polymers: hydroxypropylmethylcellulose (HPMC) and sodium ..
  9. ncbi Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients
    Boris Krischek
    Department of Neurosurgery, Tokyo Women s Medical University
    Neurol Med Chir (Tokyo) 47:389-94; discussion 394-6. 2007
    ..b>Nicardipine prolonged-release implants (NPRIs) have been used to prevent vasospasm in patients with SAH since October 1999...
  10. ncbi Effects of nicardipine and bupivacaine on early after depolarization in rabbit sinoatrial node cells: a possible mechanism of bupivacaine-induced arrhythmias
    T Matsuda
    Department of Anesthesiology, Kanazawa Medical University, Ishikawa, Japan
    Gen Pharmacol 33:115-25. 1999
    The effects of nicardipine and bupivacaine on early afterdepolarizations (EADs) were investigated in rabbit sinoatrial (SA) nodes using the conventional microelectrode technique...
  11. ncbi Effect of nicardipine treatment on the expression of neurofilament 200 KDa immunoreactivity in the brain of spontaneously hypertensive rats
    M Sabbatini
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, , Italy
    Clin Exp Hypertens 23:127-41. 2001
    ..The effect of long-term treatment with the dihydropyridine-type Ca2+ antagonist nicardipine on the expression of P-NFP was investigated as well...
  12. ncbi Nicardipine versus nitroprusside for deliberate hypotension during idiopathic scoliosis repair
    Stewart J Lustik
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Clin Anesth 16:25-33. 2004
    To compare coagulation, blood loss, and transfusion requirements between patients receiving nicardipine and nitroprusside for deliberate hypotension during idiopathic scoliosis repair.
  13. ncbi Intravenous nicardipine: its use in the short-term treatment of hypertension and various other indications
    Monique P Curran
    Adis International Limited, Auckland, New Zealand
    Drugs 66:1755-82. 2006
    b>Nicardipine is a water soluble calcium channel antagonist, with predominantly vasodilatory actions...
  14. ncbi Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention
    Raymond I Huang
    Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Catheter Cardiovasc Interv 68:671-6. 2006
    The goal of this study was to evaluate the safety and efficacy of nicardipine in reversing no-reflow during percutaneous coronary intervention (PCI).
  15. doi Management of hypertensive emergencies in acute brain disease: evaluation of the treatment effects of intravenous nicardipine on cerebral oxygenation
    Pradeep K Narotam
    Division of Neurosurgery, Creighton University Medical Center, Omaha, Nebraska, USA
    J Neurosurg 109:1065-74. 2008
    Inappropriate sudden blood pressure (BP) reductions may adversely affect cerebral perfusion. This study explores the effect of nicardipine on regional brain tissue O(2) (PbtO(2)) during treatment of acute hypertensive emergencies.
  16. ncbi Multimodal molecular encapsulation of nicardipine hydrochloride by beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and triacetyl-beta-cyclodextrin in solution. Structural studies by 1H NMR and ROESY experiments
    Catarina M Fernandes
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000 Coimbra, Portugal
    Eur J Pharm Sci 18:285-96. 2003
    ..complexes, was used to study and structurally characterize the inclusion compounds formed in solution between nicardipine hydrochloride (NC) and beta-cyclodextrin (betaCD), hydroxypropyl-beta-cyclodextrin (HPbetaCD) and triacetyl-..
  17. doi Characterization of functional outcome and quality of life following subarachnoid hemorrhage in patients treated with and without nicardipine prolonged-release implants
    Martin Barth
    Department of Neurosurgery, University Hospital, Mannheim Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Neurosurg 110:955-60. 2009
    The use of nicardipine prolonged-release implants (NPRIs) is associated with a significant improvement in the therapy of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) regarding the occurrence and severity of cerebral ..
  18. doi The use of nicardipine prolonged release implants (NPRI) in microsurgical clipping after aneurysmal subarachnoid haemorrhage: comparison with endovascular treatment
    Ulf C Schneider
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Acta Neurochir (Wien) 153:2119-25. 2011
    b>Nicardipine prolonged release implants (NPRI) have been shown to decrease the incidence of cerebral vasospasm and infarcts significantly in patients after aneurysmal subarachnoid haemorrhage (SAH) following microsurgical clipping...
  19. doi Effects of lovastatin on the pharmacokinetics of nicardipine in rats
    Joong W Chung
    College of Medicine, Chosun University, Dong Gu, Gwangju, South Korea
    Biopharm Drug Dispos 31:436-41. 2010
    It has been reported that both nicardipine and lovastatin are substrates of both the cytochrome P450 (CYP) 3A subfamily and P-glycoprotein (P-gp), and P-gp transport is unlikely to be a significant factor...
  20. doi Super-selective intra-arterial magnesium sulfate in combination with nicardipine for the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage
    Qaisar A Shah
    Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA
    Neurocrit Care 11:190-8. 2009
    To determine the safety and tolerability of super-selective intra-arterial magnesium sulfate in combination with intra-arterial nicardipine in patients with cerebral vasospasm after subarachnoid hemorrhage.
  21. doi Feasibility of intraventricular nicardipine prolonged release implants in patients following aneurysmal subarachnoid haemorrhage
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Br J Neurosurg 25:677-83. 2011
    Intracisternal nicardipine prolonged release implants (NPRI) have been shown to be effective in the prophylaxis of cerebral vasospasm (VS). However, they cannot be used in patients following coil occlusion of the aneurysm...
  22. ncbi Assessment of blood pressure during naproxen therapy in hypertensive patients treated with nicardipine
    D K Klassen
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 8:146-53. 1995
    ..One hundred patients with stable blood pressure control on 30 mg nicardipine three times a day were treated with 375 mg naproxen twice a day or placebo for 4 weeks...
  23. doi Nicardipine pellets for the prevention of cerebral vasospasm
    Claudius Thome
    Department of Neurosurgery, Innsbruck Medical University, Anichstr 35, A 6020, Innsbruck, Austria
    Acta Neurochir Suppl 110:209-11. 2011
    ..has been associated with significant side effects and insufficient efficacy, intrathecal administration of nicardipine prolonged-release implants (NPRI) has been developed...
  24. doi A new antispastic solution for arterial grafting: nicardipine and nitroglycerin cocktail in preparation of internal thoracic and radial arteries for coronary surgery
    Guo Wei He
    Nankai University Medical College and TEDA International Cardiovascular Hospital, Tianjin, China
    J Thorac Cardiovasc Surg 136:673-80, 680.e1-2. 2008
    ..We designed a new nicardipine and nitroglycerin cocktail that is composed of a second-generation dihydropyridine calcium antagonist, ..
  25. ncbi Antioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipine
    E Y Sozmen
    Department of Biochemistry, Faculty of Medicine, Ege University, Izmir, Turkey
    Clin Chem Lab Med 38:21-5. 2000
    ..We investigated the effects of collaring and nicardipine treatment on the activities of antioxidant enzymes, superoxide dismutase and catalase, and total nitrite/..
  26. ncbi [Case of autonomic hyperreflexia treated with intravenous nicardipine]
    Junichi Saito
    Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036 8562
    Masui 58:1528-30. 2009
    ..Diagnosis of AH was made. Then nicardipine 1 mg i.v...
  27. ncbi Intravenous nicardipine for treatment of severe hypertension in children
    J T Flynn
    Division of Pediatric Nephrology, Department of Pediatrics and Communicable Diseases, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, USA
    J Pediatr 139:38-43. 2001
    OBJECTIVE: To examine the effect of intravenous nicardipine in the treatment of children with severe hypertension...
  28. ncbi Effects of diltiazem compared with nicardipine on diaphragmatic fatigability in vivo
    Y Fujii
    Eur J Anaesthesiol 20:575-6. 2003
  29. ncbi Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage
    Hidetoshi Kasuya
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    Neurosurgery 56:895-902; discussion 895-902. 2005
    Since October 1999, nicardipine prolonged-release implants (NPRIs) have been used to prevent vasospasm in patients with subarachnoid hemorrhage...
  30. ncbi Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage
    W J Powers
    Department of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience, Washington University School of Medicine, St Louis, MO 631101, USA
    Neurology 57:18-24. 2001
    ..The authors undertook this study to provide further information on the changes in whole-brain and periclot regional CBF that occur with pharmacologic reductions in mean arterial pressure (MAP) in patients with acute ICH...
  31. ncbi Photostability studies on nicardipine-cyclodextrin complexes by capillary electrophoresis
    R Pomponio
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 35:267-75. 2004
    b>Nicardipine (NC)-cyclodextrin solid systems were prepared in equimolar ratios and their photostability in aqueous solution under exposure to UV(A)-UV(B) radiations was evaluated...
  32. ncbi Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting
    I A Apostolidou
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 67:417-22. 1999
    We assessed the efficacy of a continuous infusion of nicardipine and nitroglycerin in reducing the incidence and severity of perioperative myocardial ischemia during elective coronary artery bypass grafting procedures in a prospective, ..
  33. pmc Nicardipine-sensitive Na+-mediated single channel currents in guinea-pig sinoatrial node pacemaker cells
    T Mitsuiye
    Department of Physiology, Faculty of Medicine, Kyoto University, Sakyo ku, Yoshida Konoe, Kyoto 606 8501, Japan
    J Physiol 521:69-79. 1999
    ..Overlapping of ist events was observed and ist was abolished by bath application of nicardipine. 3...
  34. ncbi Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders
    H Matsumoto
    Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Oral Sci 43:261-8. 2001
    ..derived from patients reactive to nifedipine might be susceptible to the other calcium-channel blockers (nicardipine, verapamil and diltiazem) in terms of cell proliferation, DNA synthesis, and collagen synthesis...
  35. ncbi The diagnosis and management of hypertensive crises
    J Varon
    Department of Medicine, Baylor College of Medicine, Houston TX, USA
    Chest 118:214-27. 2000
    ..This article reviews some of the current concepts and common misconceptions in the management of patients with acutely elevated BP...
  36. doi A nicardipine-sensitive Ca2+ entry contributes to the hypotonicity-induced increase in [Ca2+]i of principal cells in rat cortical collecting duct
    You Komagiri
    Department of Physiology, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan
    Cell Calcium 49:35-42. 2011
    ..On the other hand, a voltage-gated Ca(2+) channel inhibitor, nicardipine, significantly reduced the peak amplitude of [Ca(2+)](i) increase in the principal cells...
  37. doi Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone
    Ulrich Schmidt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Anesth Analg 110:895-902. 2010
    ..Although endovascular treatment with intraarterial nicardipine and milrinone is an accepted clinical treatment strategy, there is little information either on hemodynamic ..
  38. doi Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy
    Jang Eun Cho
    Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Urology 73:1056-60. 2009
    To investigate the renoprotective effect of nicardipine in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) in a prospective trial...
  39. doi Nicardipine use in cerebrovascular disease: a review of controlled clinical studies
    Francesco Amenta
    Clinical Research Centre, Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
    J Neurol Sci 283:219-23. 2009
    b>Nicardipine is a dihydropyridine-type Ca(2+) channel blocker (CCB) with strong antihypertensive activity and with a peculiar cerebrovascular profile...
  40. ncbi Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol
    Jun Shik Choi
    College of Pharmacy, Chosun University, Gwangju, Korea
    Pharmazie 64:49-52. 2009
    The present study aimed to assess the effect of resveratrol on the bioavailability of nicardipine in rats...
  41. doi A comparison of nicardipine and labetalol for acute hypertension management following stroke
    Xi Liu-Deryke
    Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, 48201, USA
    Neurocrit Care 9:167-76. 2008
    Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke.
  42. ncbi The effect of intraoperative use of esmolol and nicardipine on recovery after ambulatory surgery
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9068, USA
    Anesth Analg 97:1633-8. 2003
    ..followed by an esmolol infusion 5 microg x kg(-1) x min(-1); and Group 3 (n = 15) received esmolol 50 mg and nicardipine 1 mg, followed by an esmolol infusion 5 microg x kg(-1) x min(-1)...
  43. ncbi Effect of limonene on the in vitro permeation of nicardipine hydrochloride across the excised rat abdominal skin
    Y S R Krishnaiah
    Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India
    Pharmazie 57:842-7. 2002
    The aim of the present investigation was to study the effect of limonene on in vitro permeation of nicardipine hydrochloride across the excised rat abdominal skin from a 2% w/w hydroxypropyl cellulose (HPC) gel...
  44. ncbi Preliminary experience with intra-arterial nicardipine as a treatment for cerebral vasospasm
    Neeraj Badjatia
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    AJNR Am J Neuroradiol 25:819-26. 2004
    ..We prospectively studied the use of IA nicardipine as a treatment for vasospasm.
  45. ncbi Acute pulmonary oedema during nicardipine therapy for premature labour; Report of five cases
    Pascal Vaast
    Service de pathologie maternelle et foetale, Hopital Jeanne de Flandre, 2 Avenue Oscar Lambret, CHRU Lille, 59000 Lille, France
    Eur J Obstet Gynecol Reprod Biol 113:98-9. 2004
    We report five maternal cases of acute pulmonary oedema which occurred during treatment with nicardipine for tocolysis.
  46. ncbi [Acute pulmonary edema during nicardipine and salbutamol therapy for preterm labor in twin pregnancy]
    C Chapuis
    Service du SAMU, 38, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 09
    J Gynecol Obstet Biol Reprod (Paris) 34:493-6. 2005
    ..of a multiple pregnancy who experienced acute pulmonary edema more than 48 hours after tocolytic treatment with nicardipine and salbutamol...
  47. ncbi Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine
    Brian L Hoh
    Endovascular Neurosurgery, Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School, VBK 710, 55 Fruit Street, Boston, MA 02114, USA
    Neurosurg Clin N Am 16:501-16, vi. 2005
    ..9% complications. Intra-arterial nicardipine therapy produced clinical improvement in 42% of patients, significantly improved mean TCD velocities (P <...
  48. ncbi Influence of limonene on the bioavailability of nicardipine hydrochloride from membrane-moderated transdermal therapeutic systems in human volunteers
    Y S R Krishnaiah
    Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India
    Int J Pharm 247:91-102. 2002
    The aim of the present study was to develop a membrane-moderated transdermal therapeutic system (TTS) of nicardipine hydrochloride using 2%w/w hydroxy propyl cellulose (HPC) gel as a reservoir system containing 4%w/w of limonene as a ..
  49. ncbi Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage
    M Suzuki
    Department of Neurosurgery, Clinical Neuroscience, Yamaguchi University School of Medicine, Ube, Japan
    Neurosurg Rev 24:180-4. 2001
    To evaluate the prophylactic effect of repeated intrathecal administration of nicardipine associated with hypertensive hypervolemic hemodilution therapy (triple H) and sodium correction, we analyzed a consecutive series of 177 patients ..
  50. ncbi Physicochemical characterization and in vitro dissolution behavior of nicardipine-cyclodextrins inclusion compounds
    Catarina M Fernandes
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
    Eur J Pharm Sci 15:79-88. 2002
    Inclusion complexation between nicardipine hydrochloride (NC), a calcium-channel antagonist, and beta-cyclodextrin (beta-CD) or hydroxypropyl-beta-cyclodextrin (HPbetaCD) was evaluated in aqueous environment and in solid state...
  51. ncbi Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formulation of nicardipine: in vitro evaluation and bioavailability studies in rabbits
    Catarina Marques Fernandes
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Rua do Norte, 3000, Coimbra, Portugal
    J Control Release 88:127-34. 2003
    The feasibility of using complexes with cyclodextrins (CDs) in nicardipine (NC) controlled delivery has been examined, with a view to extending the pharmaceutical applications spectrum of these carriers...
  52. ncbi Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation
    P H Tan
    Department of Anaesthesiology, Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, China
    Anaesthesia 57:1207-12. 2002
    We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation...
  53. ncbi Enhanced percutaneous permeability of nicardipine hydrochloride by carvone across the rat abdominal skin
    Y S R Krishnaiah
    Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India
    Drug Dev Ind Pharm 29:191-202. 2003
    The purpose of this study was to investigate the effect of carvone on the permeation of nicardipine hydrochloride across the excised rat abdominal epidermis from 2% w/w hydroxypropyl cellulose (HPC) gel system...
  54. ncbi Effect of the hydrophobic nature of triacetyl-beta-cyclodextrin on the complexation with nicardipine hydrochloride: physicochemical and dissolution properties of the kneaded and spray-dried complexes
    Catarina Marques Fernandes
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
    Chem Pharm Bull (Tokyo) 50:1597-602. 2002
    ..of triacetyl-beta-cyclodextrin (TAbetaCD), a hydrophobic cyclodextrin (CD) derivative was examined, using nicardipine hydrochloride (NC) as model drug...
  55. ncbi The in vitro effect of dual combinations of ritodrine, nicardipine and atosiban on contractility of pregnant rat myometrium
    Muriel Doret
    Department of Obstetrics and Gynaecology, Edouard Herriot Hospital, 1 Place d Arsonval, 69008 Lyon, France
    BJOG 110:731-4. 2003
    To compare the tocolytic potency of ritodrine, nicardipine and atosiban, used alone and in dual combinations, to see whether combinations of these drugs, which act via different pathways, could improve inhibition of uterine contractility.
  56. ncbi Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans
    Hidetoshi Kasuya
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    Stroke 33:1011-5. 2002
    ..This study was conducted to examine the efficacy and safety of nicardipine prolonged-release implants (NPRI) for humans, which have already been proven in dogs.
  57. ncbi Penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through excised rat epidermis from hydroxypropyl cellulose gels
    Y S R Krishnaiah
    Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India
    Pharm Dev Technol 7:305-15. 2002
    ..the present investigation is to study the penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through the excised rat epidermis from 2% w/w hydroxypropyl cellulose (HPC) gel system...
  58. ncbi Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats
    Hideyuki Okano
    Department of Environmental Health, National Institute of Public Health, Saitama 351 0197, Japan
    Clin Hemorheol Microcirc 34:303-8. 2006
    ..4 mm in diameter, 2.2 mm in height). An L-type voltage-gated Ca2+ channel blocker, nicardipine (2 mg/kg) was administered intraperitoneally three times a week for 6 weeks, and then 15 min after each ..
  59. doi Nicardipine and adenosine "flush cocktail" to prevent no-reflow during rotational atherectomy
    Tim A Fischell
    Michigan State University, Heart Institute at Borgess Medical Center, 1521 Gull Road, Kalamazoo, MI 49001, USA
    Cardiovasc Revasc Med 9:224-8. 2008
    ..This microscopic atheroembolic debris can lead to platelet activation, with vasoconstriction and/or mechanical obstruction of distal coronary resistance vessels, leading to no-reflow and myocardial necrosis...
  60. doi The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients
    Solomon Aronson
    Department of Anesthesiology, Duke University Medical Center, Duke South, Room 102 Baker House, Durham, NC 27710, USA
    Anesth Analg 107:1110-21. 2008
    ..performed to compare the safety and efficacy of clevidipine (CLV) with nitroglycerin (NTG), sodium nitroprusside (SNP), and nicardipine (NIC) in the treatment of perioperative acute hypertension in patients undergoing cardiac surgery.
  61. ncbi Effect of antihypertensive therapy on aortic distensibility in patients with essential hypertension: comparison with trichlormethiazide, nicardipine and alacepril
    T Honda
    Department of Internal Medicine, Saiseikai Saijo Hospital, Ehime, Japan
    Cardiovasc Drugs Ther 13:339-46. 1999
    ..were divided into three groups and treated for 12 weeks with 2-4 mg trichlormethiazide per day (n = 10), 80 mg nicardipine per day (n = 13) and 50 mg alacepril per day (n = 10)...
  62. doi Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study
    Masumi Miyazaki
    Department of Anesthesia, Tomioka General Hospital, Tomioka, Japan
    J Clin Anesth 20:257-62. 2008
    To examine the comparative effects of propofol, landiolol, and nicardipine on hemodynamic responses and bispectral index (BIS) changes to endotracheal intubation.
  63. ncbi Nicardipine versus salbutamol in the treatment of premature labor: comparison of their efficacy and side effects
    Khaled Trabelsi
    Department of Obstetrics and Gynecology, Hedi Chaker University Hospital, Sfax, Tunisia
    Tunis Med 86:43-8. 2008
    To compare the tocolytic action and the side effects of nicardipine to those of salbutamol in patients presenting premature labor in order to propose nicardipine as a promising alternative to salbutamol in the treatment of premature labor.
  64. ncbi [Acute pulmonary edema during preterm labor: role of nicardipine tocolysis (three cases)]
    S Janower
    Service de cardiologie
    J Gynecol Obstet Biol Reprod (Paris) 34:807-12. 2005
    ..cases of pulmonary edema during preterm labor associated with the use of calcium channel blocker, intravenous nicardipine, widely used for tocolysis in France...
  65. ncbi Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation
    J H Kim
    Department of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Korea
    J Int Med Res 35:52-8. 2007
    We investigated the effect of IV nicardipine on haemodynamic and bispectral index responses to the induction of general anaesthesia and intubation...
  66. ncbi Nicardipine improves the antidepressant action of ECT but does not improve cognition
    S L Dubovsky
    Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
    J ECT 17:3-10. 2001
    ..METHOD: The lipid-soluble calcium channel-blocking drug nicardipine or matching placebo were randomly assigned to 26 patients with major depressive disorder receiving ECT...
  67. ncbi Effects of nicardipine and diltiazem on the bispectral index and 95% spectral edge frequency
    K Hirota
    University of Hirosaki School of Medicine, Department of Anesthesiology, Hirosaki, Japan
    Eur J Anaesthesiol 20:809-12. 2003
    ..As the bispectral index correlates with the depth of sedation, we examined whether L-type Ca2+ channel blocking agents affect the bispectral index...
  68. ncbi Treatment with nicardipine protects brain in an animal model of hypertension-induced damage
    Francesco Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Camerino, Italy
    Clin Exp Hypertens 26:351-61. 2004
    ..This study has assessed the influence of treatment with the dihydropyridine-type Ca2+ antagonist nicardipine on brain microanatomical changes in spontaneously hypertensive rats (SHR)...
  69. ncbi Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists?
    Ferdinand Kouoh
    Laboratoire de Pharmacologie, Pharmacocinetique et Pharmacie Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France
    Cardiovasc Drugs Ther 16:515-20. 2002
    ..In the present study, we have shown that nicardipine, a calcium channel blocker, affects the release of elastase and superoxide anion radicals (O(2-)) in vitro ..
  70. ncbi The comparative effects of intravenous nicardipine and prostaglandin E1 on the cerebral pial arteriolar constriction seen after unclamping of an aortic cross-clamp in rabbits
    Masahiko Kumazawa
    Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu City, Gifu, Japan
    Anesth Analg 104:659-65. 2007
    The potent vasodilators nicardipine and prostaglandin E1 (PGE1) are useful for the treatment of systemic hypertension or pulmonary hypertension during aortic surgery.
  71. ncbi Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations
    Kazuyuki Daitoku
    Department of Pharmacology, Hirosaki University Graduate School of Medicine, Japan
    Tohoku J Exp Med 212:415-22. 2007
    ..Cilnidipine and nicardipine, a selective L-type Ca(2+) channel blocker, but not omega-conotoxin GVIA (omega-CTX), a selective N-type Ca(2+) ..
  72. ncbi Induction of hepatic cytochrome P450 isoforms by nicardipine at therapeutic doses in spontaneously hypertensive rats
    Shoji Miyajima
    Department of Molecular Toxicology, COE Program in the 21st Century, School of Pharaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Toxicol Sci 32:79-90. 2007
    b>Nicardipine hydrochloride (Nic), a calcium channel antagonist, is used for the treatment of hypertension...
  73. ncbi Vasodilation increases the threshold for bupivacaine-induced convulsions in rats
    Yutaka Oda
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Anesth Analg 98:677-82, table of contents. 2004
    ..Male Sprague-Dawley rats were randomly divided into control (C), nicardipine (N), and phentolamine (P) groups (n = 12 in each group)...
  74. ncbi Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells
    Kunio Koshimura
    First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
    Metabolism 52:922-6. 2003
    ..Glucose-induced increase in dopamine release was blunted by nicardipine, a Ca2+ channel blocker. Following addition of 13...
  75. ncbi Effects of neck exposure to 5.5 mT static magnetic field on pharmacologically modulated blood pressure in conscious rabbits
    Hideyuki Okano
    Department of Environmental Health, National Institute of Public Health, Saitama, Japan
    Bioelectromagnetics 26:469-80. 2005
    ..BP; norepinephrine (NE)-induced hypertension as well as an L-type voltage-gated Ca(2+) channel blocker, nicardipine (NIC)-induced hypotension in conscious rabbits. Magnetic flux densities were up to 5...
  76. ncbi The visceromotor responses to colorectal distension and skin pinch are inhibited by simultaneous jejunal distension
    Anthony D Shafton
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, Vic, 3010, Australia
    Pain 123:127-36. 2006
    ..distension was prevented by local application of tetrodotoxin to the jejunum, and was markedly reduced when nicardipine was infused into the local jejunal circulation...
  77. ncbi Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats
    Minori Nakamoto
    Department of Cardiovascular Medicine, Nephrology and Neurology, School of Medicine, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 30:359-66. 2007
    ..Oral administration of high-dose azelnidipine (10 mg/kg per day) or nicardipine (150 mg/kg per day) for 10 days caused a significant and comparable decrease in blood pressure, but low-dose ..
  78. ncbi Large artery compliance in essential hypertension. Effects of calcium antagonism and beta-blocking
    R De Cesaris
    Department of Biomedical Science and Human Oncology, University of Bari Medical School, Italy
    Am J Hypertens 5:624-8. 1992
    ..This study used 2D Doppler flowmetry to assess the effects on peripheral hemodynamics of effective treatment with nicardipine or atenolol in 40 patients with mild or moderate essential hypertension...
  79. ncbi A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons
    Manabu Arioka
    Department of Biotechnology, The University of Tokyo, Bunkyo ku, Japan
    FEBS Lett 579:2693-701. 2005
    ..sPLA(2) was inhibited by depletion of extracellular Ca(2+) or by the presence of L-type Ca(2+) channel blocker nicardipine, suggesting that Ca(2+) influx occurs upon sPLA(2) treatment...
  80. pmc Inhibitory effects of potassium channel blockers on carbachol-induced contraction in rat detrusor muscle
    Seung June Oh
    Department of Urology, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Korean Med Sci 18:701-6. 2003
    ..The potentiation of phasic contraction was not observed in nicardipine pretreated condition...
  81. ncbi Voltage-gated Ca2+ currents are necessary for slow-wave propagation in the canine gastric antrum
    Orline Bayguinov
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Physiol Cell Physiol 293:C1645-59. 2007
    ..b>Nicardipine (0.1-1 microM) did not affect slow-wave upstroke or propagation velocities...
  82. ncbi Mechanism of the ropivacaine-induced increase in intracellular Ca2+ concentration in rat aortic smooth muscle
    Y Tokinaga
    Surgical Operating Center, Wakayama Medical University, Wakayama City, Japan
    Acta Anaesthesiol Scand 51:1155-60. 2007
    ..Therefore, the aim of this study was to examine the mechanism underlying the increase in [Ca(2+)](i) in ropivacaine-induced vascular contraction...
  83. ncbi A review of calcium channel antagonists in the treatment of pediatric hypertension
    Shobha Sahney
    Division of Pediatric Nephrology, Loma Linda Children s Hospital, Loma Linda, California 92354, USA
    Paediatr Drugs 8:357-73. 2006
    ..Oral short-acting nifedipine and intravenous nicardipine are safe and effective CCAs for the management of hypertensive crisis in children...
  84. ncbi Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients
    Lidwien M Hanff
    Department of Hospital Pharmacy, Rotterdam, The Netherlands
    J Hypertens 23:2319-26. 2005
    To evaluate the efficacy of intravenous administration of nicardipine as a second-line temporizing treatment in severe, early-onset, pre-eclamptic patients.
  85. ncbi Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta
    Mee Ra Rhyu
    Function Research Division, Korea Food Research Institute, Gyeonggi Do, Korea
    J Cardiovasc Pharmacol 46:99-104. 2005
    ..A substance other than ferulic acid might create these effects...
  86. ncbi Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri
    Toru Iizuka
    Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Biol Pharm Bull 29:177-9. 2006
    ..by a high concentration (60 mM) of K+, whereas it inhibited NE-induced vasocontraction in the presence of nicardipine. These results suggest that the inhibition of NE-induced vasocontraction by compound 1 is in part attributable ..
  87. ncbi Nicardipine, a calcium antagonist, does not aggravate intracerebral haemorrhage in an intracerebral haemorrhage model in rats
    Masanori Suzuki
    Applied Pharmacology Research, Pharmacology Laboratories, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    J Pharm Pharmacol 57:483-8. 2005
    ..Here, we investigated the effects of nicardipine on haematoma size and neurological deficit in a rat model of collagenase-induced intracerebral haemorrhage...
  88. ncbi Determination of nifedipine in serum of women in preterm labor by high-performance liquid chromatography with diode array detection
    Dorota Kowalczuk
    Medical University of Lublin, Faculty of Pharmacy, Department of Medicinal Chemistry, 6 Chodzki Str, 20 093 Lublin, Poland
    J AOAC Int 89:71-7. 2006
    ..5 ng/mL, respectively. Validation of the method demonstrated good intraday and interday precision, which ranged from 2.18 to 6.67% and from 6.52 to 11.93%, respectively...
  89. ncbi C-type natriuretic peptide inhibits L-type Ca2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor
    Robert A Rose
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada
    J Neurophysiol 94:612-21. 2005
    ..These data represent the first electrophysiological evidence of a functional role for the NPR-C receptor in the mammalian hypothalamus...
  90. ncbi The use of nicardipine for electroconvulsive therapy: a dose-ranging study
    Yunan Zhang
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9068, USA
    Anesth Analg 100:378-81. 2005
    ..designed this randomized, double-blind, saline-controlled, crossover study to compare three different doses of nicardipine when administered before the ECT stimulus...
  91. ncbi Analysis of responses to kava kava in the feline pulmonary vascular bed
    Jason M Hoover
    Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Med Food 9:62-71. 2006
    ..glibenclamide, an ATP-sensitive K+ channel blocker, meclofenamate, a nonselective cyclooxygenase inhibitor, nicardipine, a calcium channel blocker, bicuculline, a gamma-aminobutyric acid (GABA)A receptor antagonist, and saclofen, a ..
  92. ncbi Ionic mechanism for contractile response to hyposmotic challenge in canine basilar arteries
    Shunsuke Yano
    Department of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka City, Shizuoka 422 8526, Japan
    Am J Physiol Cell Physiol 288:C702-9. 2005
    ..abolished by the removal of extracellular Ca(2+) and by the voltage-dependent Ca(2+) channel (VDCC) blocker nicardipine, but it was unaffected by thapsigargin, which depletes intracellular Ca(2+) stores...
  93. ncbi Factors affecting habituation of PC12 cells to ATP
    J Russel Keath
    Department Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Eur J Biochem 271:4034-41. 2004
    ..calcium channels does not appear to contribute to secretion during ATP stimulation, blocking these channels with nicardipine increases habituation. This suggests a role for voltage-operated calcium channels in the habituation process.
  94. ncbi Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
    Atsushi Kakizaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 536:223-31. 2006
    ....
  95. ncbi The role of calcium channels in substance P-induced contractile response in the rat iris
    Astor Grumann Junior
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Rua Ferrreira Lima 82, 88015 420 Florianópolis, SC, Brazil
    Peptides 24:1985-91. 2003
    ..However, pre-incubation of the preparations with nicardipine (1 microM) or ruthenium red (1 mM) caused parallel displacement to the right of the substance P concentration-..
  96. ncbi Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders
    Magali Savignac
    Institut National de la Santé et de la Recherche Médicale Unité 563, Institut Federatif de Recherche 30, Hopital Purpan, Toulouse, France
    J Immunol 172:5206-12. 2004
    ..b>Nicardipine, an inhibitor of DHPR, is beneficial in experimental models of Th2-dependent pathologies in rats...
  97. ncbi Long-term anti-hypertensive therapy with benidipine improves arterial stiffness over blood pressure lowering
    Toshihiro Kita
    The First Department of Internal Medicine, Miyazaki Medical School, 5200 Kihara, Kiyotake, 889 1692, Miyazaki, Japan
    Hypertens Res 28:959-64. 2005
    ..In the short-term experiment, 29 participants were intravenously administered nicardipine for 90 min...
  98. ncbi Pathophysiology and medical management of systemic hypertension in preeclampsia
    William H Frishman
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Curr Hypertens Rep 8:502-11. 2006
    ....
  99. ncbi Sex difference in induction of hepatic CYP2B and CYP3A subfamily enzymes by nicardipine and nifedipine in rats
    Yoshihiro Konno
    Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Toxicol Appl Pharmacol 196:20-8. 2004
    Male and female of F344 rats were treated per os with nicardipine (Nic) and nifedipine (Nif), and changes in the levels of mRNA and protein of hepatic cytochrome P450 (P450) enzymes, CYP2B1, CYP2B2, CYP3A1, CYP3A2, CYP3A9, and CYP3A18 ..
  100. ncbi Exposure to a moderate intensity static magnetic field enhances the hypotensive effect of a calcium channel blocker in spontaneously hypertensive rats
    Hideyuki Okano
    Department of Environmental Health, National Institute of Public Health, Saitama, Japan
    Bioelectromagnetics 26:611-23. 2005
    ..effects of a moderate intensity static magnetic field (SMF) and an L-type voltage-gated Ca(2+) channel blocker, nicardipine in stroke-resistant spontaneously hypertensive rats during the development of hypertension...
  101. ncbi Sodium nitroprusside-induced rat fundus relaxation is ryanodine-sensitive and involves L-type Ca2+ channel and small conductance Ca(2+)-sensitive K+ channel components
    J Geeson
    School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK
    Auton Autacoid Pharmacol 22:297-301. 2002
    ..small conductance Ca(2+)-sensitive K+ channel, SKCa, inhibitor) or the selective L-type Ca2+ channel inhibitor, nicardipine (3 microM)...

Research Grants78

  1. Anti-hypertensive drugs that prevent Alzheimer's disease beta-amyloid pathology a
    Giulio Pasinetti; Fiscal Year: 2007
    ..A¿) in vitro and, as recently found, also in vivo in response to treatment with propranolol-HCI, nicardipine-HCI, losartan in Tg2576 mice, even when these drugs were delivered in a short term dosing regimen at ..
  2. Antihypertensive Treatment in Acute Cerebral Hemorrhage
    Adnan Qureshi; Fiscal Year: 2006
    ..is proposed to evaluate the treatment feasibility and safety of antihypertensive (anti HTN) treatment (with nicardipine) in subjects with acute HTN associated with ICH...
  3. Etiology of Sleep Apnea-Related Hyperaldosteronism
    David Calhoun; Fiscal Year: 2007
    ..Subjects found not to have OSA will serve as controls. ..
  4. Etiology of Sleep Apnea-Related Hyperaldosteronism
    David A Calhoun; Fiscal Year: 2010
    ..Both possibilities would significantly lower cardiovascular risk in patients with difficult-to-control hypertension. ..
  5. G PROTEIN-MEDIATED CA++ SENSITIZATION IN SMOOTH MUSCLE
    Toshio Kitazawa; Fiscal Year: 1993
    ....
  6. G PROTEIN MEDIATED CA++ SENSITIZATION IN SMOOTH MUSCLE
    Toshio Kitazawa; Fiscal Year: 2002
    ....
  7. Synaptic Processing in the Olfactory System
    JEFFRY ISAACSON; Fiscal Year: 2009
    ..These experiments will provide new insight into the synaptic mechanisms underlying olfaction in the brain. ..
  8. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
    ....
  9. Cardioprotective Efficacy ofMg-Supplementation during HAART Therapy
    IVAN TONG MAK; Fiscal Year: 2010
    ....
  10. Protective Efficacy of Mg-Supplementation Against NRTI-induced Cardiac Toxicity
    IVAN MAK; Fiscal Year: 2007
    ..This proposed exploratory effort may reveal a potential usefulness of Mg-supplements as an effective, yet relatively inexpensive adjunct therapy to lessen NRTI-related cardiovascular toxicity. ..
  11. Synaptic Processing in the Olfactory System
    JEFFRY ISAACSON; Fiscal Year: 2007
    ..These experiments will provide new insight into the synaptic mechanisms underlying olfaction in the brain. ..
  12. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
    ....
  13. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2004
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  14. Vascular and Metabolic Mechanisms in Alzheimer's Disease
    William Powers; Fiscal Year: 2005
    ..Through the use of the unique resources and personnel at Washington University Medical Center, we have the opportunity to provide answers to important clinical and mechanistic questions in AD. ..
  15. High-Throughput Evaluation of Breast Cancer Markers
    Richard Zangar; Fiscal Year: 2006
    ....
  16. Proteomic Identification of NAF Biomarkers
    Richard Zangar; Fiscal Year: 2004
    ..Upon completion of these aims, we will have provided the first detailed characterization of the NAF proteome and identified a subset of NAF proteins that are potential markers of breast disease. ..
  17. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2007
    ....
  18. Synaptic Processing in the Olfactory System
    JEFFRY ISAACSON; Fiscal Year: 2005
    ..These experiments will provide new insight into the synaptic mechanisms underlying dendrodendritic transmission, which is of critical importance in the processing of olfactory information in the brain. ..