trazodone

Summary

Summary: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)

Top Publications

  1. ncbi Does trazodone have a role in palliating symptoms?
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, M76, Cleveland, OH 44195, USA
    Support Care Cancer 15:221-4. 2007
  2. ncbi Frontotemporal dementia: a randomised, controlled trial with trazodone
    Florence Lebert
    Memory Clinic, Lille University Hospital, Lille, France
    Dement Geriatr Cogn Disord 17:355-9. 2004
  3. ncbi Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine
    Bo Wen
    Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, New Jersey, USA
    Drug Metab Dispos 36:841-50. 2008
  4. ncbi P-glycoprotein interactions of nefazodone and trazodone in cell culture
    E Stormer
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Clin Pharmacol 41:708-14. 2001
  5. ncbi Daytime sleepiness and insomnia as correlates of depression
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 65:27-32. 2004
  6. ncbi Insomnia related to dysthymia: polysomnographic and psychometric comparison with normal controls and acute therapeutic trials with trazodone
    G M Saletu-Zyhlarz
    Department of Psychiatry, University of Vienna, Austria
    Neuropsychobiology 44:139-49. 2001
  7. ncbi Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies
    Russell P Rosenberg
    Northside Hospital Sleep Medicine Institute, Atlanta, GA, USA
    Ann Clin Psychiatry 18:49-56. 2006
  8. ncbi A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression
    Yiru Fang
    Division of Mood Disorders, Shanghai Mental Health Center, Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Psychopharmacol 31:638-42. 2011
  9. pmc Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study
    Elena P Calandre
    Instituto de Neurociencias y Centro de Investigaciones Biomédicas, Universidad de Granada, Granada, Spain
    BMC Musculoskelet Disord 12:95. 2011
  10. ncbi Effect of trazodone on hERG channel current and QT-interval
    Paul Tarantino
    Sepracor Inc, 84 Waterford Drive, Marlborough, MA 01752, United States
    Eur J Pharmacol 510:75-85. 2005

Detail Information

Publications219 found, 100 shown here

  1. ncbi Does trazodone have a role in palliating symptoms?
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, M76, Cleveland, OH 44195, USA
    Support Care Cancer 15:221-4. 2007
    b>Trazodone is a unique antidepressant, which blocks the postsynaptic serotonin (5-HT) receptors, 5-HT(2A) and 5-HT(2C), and weakly inhibits presynaptic 5-HT transporters.
  2. ncbi Frontotemporal dementia: a randomised, controlled trial with trazodone
    Florence Lebert
    Memory Clinic, Lille University Hospital, Lille, France
    Dement Geriatr Cogn Disord 17:355-9. 2004
    ..The serotonergic system is associated with frontal lobes, the degeneration of which contributes to FTD. Trazodone increases the extracellular 5-HT levels in the frontal cortex...
  3. ncbi Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine
    Bo Wen
    Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, New Jersey, USA
    Drug Metab Dispos 36:841-50. 2008
    Several new glutathione adducts (M3-M7) of trazodone were tentatively identified in human liver microsomal incubations using liquid chromatography-tandem mass spectrometry (LC/MS/MS)...
  4. ncbi P-glycoprotein interactions of nefazodone and trazodone in cell culture
    E Stormer
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Clin Pharmacol 41:708-14. 2001
    This study investigated the effects of nefazodone (NFZ) and trazodone (TZD) on P-glycoprotein (P-gp) activity and expression in cell culture...
  5. ncbi Daytime sleepiness and insomnia as correlates of depression
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 65:27-32. 2004
    ..Finally, several different treatment options, including antidepressant monotherapy and augmentation of antidepressants with other medications, are explored...
  6. ncbi Insomnia related to dysthymia: polysomnographic and psychometric comparison with normal controls and acute therapeutic trials with trazodone
    G M Saletu-Zyhlarz
    Department of Psychiatry, University of Vienna, Austria
    Neuropsychobiology 44:139-49. 2001
    ..In a placebo-controlled crossover design study, the acute effects of 100 mg trazodone, a serotonin reuptake inhibitor with a sedative action due to 5HT(2) and alpha(1) receptor blockade, were ..
  7. ncbi Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies
    Russell P Rosenberg
    Northside Hospital Sleep Medicine Institute, Atlanta, GA, USA
    Ann Clin Psychiatry 18:49-56. 2006
    ..When insomnia is recognized, considerable emphasis has been placed on improving sleep onset; however, there is growing evidence that improving sleep maintenance is an equally important treatment goal...
  8. ncbi A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression
    Yiru Fang
    Division of Mood Disorders, Shanghai Mental Health Center, Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Psychopharmacol 31:638-42. 2011
    To compare the efficacy and safety of augmenting paroxetine with risperidone, buspirone, valproate, trazodone, or thyroid hormone in patients with treatment-resistant depression (TRD), 225 patients with retrospectively and/or ..
  9. pmc Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study
    Elena P Calandre
    Instituto de Neurociencias y Centro de Investigaciones Biomédicas, Universidad de Granada, Granada, Spain
    BMC Musculoskelet Disord 12:95. 2011
    Although trazodone is frequently used by fibromyalgia patients, its efficacy on this disease has not been adequately studied...
  10. ncbi Effect of trazodone on hERG channel current and QT-interval
    Paul Tarantino
    Sepracor Inc, 84 Waterford Drive, Marlborough, MA 01752, United States
    Eur J Pharmacol 510:75-85. 2005
    b>Trazodone has been associated with prolonged QT-interval and increased risk of polymorphous ventricular tachycardias clinically and has demonstrated in vitro inhibition of hERG (human ether-á-go-go-related gene) channel current...
  11. ncbi Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice
    X Li
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Pharmazie 66:282-6. 2011
    ..inflammatory bowel disease (5-aminosalicylic acid), an antibiotic drug (tetracycline), an antidepressant drug (trazodone), and an antipyretic drug (acetaminophen) in mice...
  12. ncbi A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy
    Adrienne Einarson
    Motherisk Program, Division of Clinical Pharmacology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8
    Can J Psychiatry 48:106-10. 2003
    b>Trazodone and nefazodone are phenylpiperazine antidepressants. Currently, there are no adequate, well-controlled studies on the fetal safety of these drugs...
  13. ncbi Trazodone for erectile dysfunction: a systematic review and meta-analysis
    H A Fink
    Geriatric Research Education and Clinical Center, Section of General Internal Medicine, VA Medical Center, Minneapolis, USA
    BJU Int 92:441-6. 2003
    To determine the efficacy and safety of trazodone in the treatment of erectile dysfunction (ED) in a meta-analysis.
  14. ncbi Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone
    David J Greenblatt
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston MA, 02111, USA
    J Clin Pharmacol 43:414-22. 2003
    ..In a single-dose, blinded, four-way crossover study, 10 healthy volunteer subjects received 50 mg of trazodone hydrochloride or matching placebo concurrent with low-dose ritonavir (four doses of 200 mg each) or with placebo...
  15. pmc Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial
    Michael D Stein
    Department of Medicine, Alpert Medical School of Brown University, Box G, Providence, RI 02912, USA michael
    Drug Alcohol Depend 120:65-73. 2012
    To test whether trazodone, one of the most commonly prescribed medications for treatment of insomnia, improves subjective and/or objective sleep among methadone-maintained persons with sleep complaints, we performed a randomized, double-..
  16. ncbi The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder
    David V Sheehan
    University of South Florida College of Medicine, Tampa, FL, USA
    Psychopharmacol Bull 42:5-22. 2009
    b>Trazodone Contramid(R) once-a-day (TzCOAD) is a reformulation of trazodone hydrochloride that controls the release of trazodone over 24 hours...
  17. ncbi [The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine]
    Adam Wichniak
    Instytut Psychiatrii i Neurologii w Warszawie, III Klinika Psychiatryczna
    Pol Merkur Lekarski 31:65-70. 2011
    ..The aim of the study was to evaluate the effects of trazodone on sleep in depressed patients in comparison to other sleep promoting antidepressants: agomelatine, ..
  18. ncbi Diagnosis and treatment of chronic insomnia: a review
    Ruth M Benca
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Psychiatr Serv 56:332-43. 2005
    ..Insomnia has high prevalence rates and is associated with significant personal and socioeconomic burden, yet it remains largely underrecognized and inadequately treated...
  19. ncbi The effects of trazodone on sleep in patients treated with stimulant antidepressants
    Hakan Kaynak
    Department of Neurology, Sleep Disorders Unit, Cerrahpasa Medical School, University of Istanbul, Cerrahpasa, 34303 Istanbul, Turkey
    Sleep Med 5:15-20. 2004
    To evaluate the effects of trazodone on subjective and objective measures of sleep in depressed insomnia patients treated with selective serotonin reuptake inhibitors (SSRIs)...
  20. ncbi Combined treatment with haloperidol and trazodone in patients with tic disorders
    L Saccomani
    Child Neuropsychiatry, DSNV, G Gaslini Institute, University of Genova, Italy
    J Child Adolesc Psychopharmacol 10:307-10. 2000
    The combination of haloperidol and trazodone was evaluated in an open-label trial in 10 patients with chronic tic and Tourette's syndrome. We found a mean reduction of symptoms of 58...
  21. ncbi Application of a trazodone-selective electrode to pharmaceutical quality control and urine analyses
    M Soledad García
    Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain
    Anal Bioanal Chem 394:1563-7. 2009
    A trazodone-selective electrode for application in pharmaceutical quality control and urine analysis was developed. The electrode is based on incorporation of a trazodone-tetraphenylborate ion exchanger in a poly(vinyl chloride) membrane...
  22. ncbi alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds
    Laura Betti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem Lett 12:437-40. 2002
    ..A 1.1 nM affinity toward alpha(1)-AR was found for compound 3, the most active of this series...
  23. ncbi Trazodone and ejaculatory inhibition
    Kenneth R Kaufman
    Department of Psychiatry, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    J Sex Marital Ther 33:225-30. 2007
    ..in a male patient with co-morbid psychiatric diagnoses treated with fluoxetine, divalproex sodium, lamotrigine, trazodone, and clonazepam. Detailed psychotropic history with time-line of adverse effect onset implicated trazodone...
  24. pmc Trazodone for the treatment of fibromyalgia: an open-label, 12-week study
    Piedad Morillas-Arques
    Instituto de Neurociencias y Centro de Investigaciones Biomédicas, Universidad de Granada, Granada, Spain
    BMC Musculoskelet Disord 11:204. 2010
    Despite its frequent use as a hypnotic, trazodone has not been systematically assessed in fibromyalgia patients...
  25. ncbi Fulminant hepatic failure induced by venlafaxine and trazodone therapy: a case report
    O Detry
    Department of Abdominal Surgery and Transplantation, CHU de Liege, University of Liege, Sart Tilman B35, B4000 Liege, Belgium
    Transplant Proc 41:3435-6. 2009
    ..Venlafaxine and trazodone are 2 popular antidepressant agents...
  26. ncbi [The effectiveness of treatment with trazodone in patients with primary insomnia without and with prior history of hypnotics use]
    Adam Wichniak
    Department of Forensic Medicine, Institute of Psychiatry and Neurology, Warsaw, Poland
    Pol Merkur Lekarski 23:41-6. 2007
    ..Antidepressants are important alternative for long-term insomnia treatment. The aim of the study was compared the efficacy of trazodone in the treatment of patients with primary insomnia with and without prior history of hypnotics use.
  27. ncbi A placebo-controlled crossover trial using trazodone in pediatric migraine
    P A Battistella
    Department of Pediatrics, University of Padua, Italy
    Headache 33:36-9. 1993
    An 8-month, double-blind, placebo-controlled cross-over trial was carried out on the use of trazodone in pediatric migraine prophylaxis...
  28. ncbi A comparative, randomized, double-blind study of trazodone prolonged-release and sertraline in the treatment of major depressive disorder
    C Munizza
    Fourth Local Health Unit, Mental Health Department, Turin, Italy
    Curr Med Res Opin 22:1703-13. 2006
    To evaluate the efficacy and safety of trazodone prolonged-release compared with sertraline in the treatment of patients with major depression.
  29. ncbi Utility of 7,7,8,8-tetracyanoquinodimethane charge transfer reagent for the spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides
    Gehad G Mohamed
    Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 68:1244-9. 2007
    ..spectrophotometric method has been developed for the determination of tricyclic anti-depressant drugs such as trazodone (TZH), amineptine (APH) and amitriptyline (ATPH) hydrochlorides in pure form and in different pharmaceutical ..
  30. ncbi New colorimetric methods for the determination of trazodone HCl, famotidine, and diltiazem HCl in their pharmaceutical dosage forms
    Magda M Ayad
    Analytical Chemical Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    Anal Bioanal Chem 376:710-4. 2003
    Two sensitive and simple spectrophotometric methods are developed for the determination of trazodone HCl, famotidine, and diltiazem HCl in pure and pharmaceutical preparations...
  31. ncbi Trazodone-induced cardiac arrhythmias: a report of two cases
    D Winkler
    Hum Psychopharmacol 21:61-2. 2006
  32. ncbi A review of the evidence for the efficacy and safety of trazodone in insomnia
    Wallace B Mendelson
    University of Chicago, Chicago, IL, USA
    J Clin Psychiatry 66:469-76. 2005
    b>Trazodone, a triazolopyridine antidepressant, is currently the second most commonly prescribed agent for the treatment of insomnia due to its sedating qualities...
  33. ncbi Voltammetric analysis of trazodone HCl in pharmaceuticals and biological fluids
    N El-Enany
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516 Mansoura, Egypt
    J Pharm Biomed Anal 30:219-26. 2002
    The voltammetric behavior of trazodone (TRZ) HCl was studied using direct current (DC(t)), differential pulse (DPP) and alternating current (AC(t)) polarography. The drug manifests cathodic waves over the pH range of 10-14...
  34. ncbi Sedation of children with ADHD: trazodone or midazolam?
    Simonetta Tesoro
    Paediatr Anaesth 17:1008-9. 2007
  35. ncbi In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone
    James A Dykens
    Drug Safety Research and Development, Pfizer, Inc, Sandwich CT139NJ, UK
    Toxicol Sci 103:335-45. 2008
    ..S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazolopyridine trazodone, plus the azaspirodecanedione buspirone, for cytotoxicity and effects on mitochondrial function...
  36. ncbi Trazodone for Alzheimer's disease: a naturalistic follow-up study
    Secundino López-Pousa
    Research Unit, Institut d Assistencia Sanitaria, Hospital Santa Caterina, Parc Hospitalari Martí i Julià, C Dr Castany s n, 17190 Salt, Girona, Spain
    Arch Gerontol Geriatr 47:207-15. 2008
    This study intended to provide a patient profile for trazodone (a triazolopyridine-derivative of phenylpiperazine) prescription in everyday clinical practice in patients with Alzheimer's disease (AD), and to describe clinical evaluation ..
  37. ncbi Spectrophotometric, spectrofluorimetric and LC determination of trazodone hydrochloride
    A el-Gindy
    Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
    J Pharm Biomed Anal 26:211-7. 2001
    Three methods are described for the determination of trazodone hydrochloride in pharmaceutical tablets...
  38. ncbi Trazodone inhibits T-type calcium channels
    Richard L Kraus
    Sleep Research Department, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA
    Neuropharmacology 53:308-17. 2007
    b>Trazodone is one of the most commonly prescribed medicines for treating depression and insomnia. However, the pharmacological mechanism of action underlying trazodone's unique effects is unclear...
  39. ncbi Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers
    L M Paterson
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    J Psychopharmacol 23:487-94. 2009
    ..study whereby subjects received placebo, caffeine (150 mg), caffeine plus zolpidem (10 mg) and caffeine plus trazodone (100 mg) at bedtime in a randomised crossover design...
  40. ncbi Therapeutic options for sleep-maintenance and sleep-onset insomnia
    Anna K Morin
    Department of Pharmacy Practice, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts 01608 1715, USA
    Pharmacotherapy 27:89-110. 2007
    ..include benzodiazepine and nonbenzodiazepine sedative-hypnotic agents; ramelteon, a melatonin receptor agonist; trazodone; and sedating antihistamines. Herbal and alternative preparations include melatonin and valerian...
  41. ncbi Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome
    Anil Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India
    Pharmacol Rep 60:664-72. 2008
    ..conducted with the aim of elucidating the possible role of nitric oxide (NO) in the neuroprotective effects of trazodone used to treat chronic fatigue syndrome (CFS) in mice...
  42. ncbi Treatment of neuroleptic-induced akathisia with the 5-HT2A antagonist trazodone
    Rafael Stryjer
    Beer Yaakov Mental Health Center, Israel
    Clin Neuropharmacol 26:137-41. 2003
    ..b>Trazodone is an antidepressant agent demonstrating prominent serotonergic antagonistic properties...
  43. ncbi Trazodone addition for insomnia in venlafaxine-treated, depressed inpatients: a semi-naturalistic study
    Gilles Bertschy
    Department of Psychiatry, University Hospital and University of Geneva, Geneva, Switzerland
    Pharmacol Res 51:79-84. 2005
    In this paper, we present the results of a prospective semi-naturalistic study of the addition of trazodone for insomnia to a 4 week, 300mg/day venlafaxine treatment in 50 depressed inpatients...
  44. ncbi Possible role of trazodone and imipramine in sleep deprivation-induced anxiety-like behavior and oxidative damage in mice
    A Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 31:383-7. 2009
    ..The present study was designed to explore the protective effects of trazodone and imipramine on 72-h sleep deprivation-induced anxiety-like behavior and oxidative damage in mice...
  45. ncbi Sensitive extractive spectrophotometric methods for the determination of trazodone hydrochloride in pharmaceutical formulations
    Ramanaboyina Sudhir Kumar
    Department of Chemistry, Karnatak University, Dharwad 580 003, India
    Chem Pharm Bull (Tokyo) 54:968-71. 2006
    Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations...
  46. ncbi Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents
    Faten A F Nour El-Dien
    Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 65:20-6. 2006
    ..spectrophotometric procedure has been developed for the determination of tricyclic anti-depressant drugs such as trazodone (TZH), amineptine (APH) and amitriptyline (ATPH) hydrochlorides in pure form and in different dosage forms...
  47. ncbi The drug treatment of depression in general practice: a comparison of nocte administration of trazodone with mianserin, dothiepin and amitriptyline
    R Blacker
    St Bartholomew s Hospital, London, UK
    Psychopharmacology (Berl) 95:S18-24. 1988
    ..multicentre study was performed to assess the efficacy and tolerability of evening administration of 150 mg trazodone as an initial and maintenance therapy and to compare this regimen with recommended dosages of mianserin, ..
  48. pmc Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial
    Peter D Friedmann
    Program to Integrate Psychosocial and Health Services, Research Service, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 32:1652-60. 2008
    b>Trazodone is a commonly prescribed off-label for sleep disturbance in alcohol-dependent patients, but its safety and efficacy for this indication is unknown.
  49. ncbi Priapism associated with trazodone in an adolescent with autism
    Deborah L Kem
    J Am Acad Child Adolesc Psychiatry 41:758. 2002
  50. ncbi Tinnitus treatment with Trazodone
    Gabriel Cesar Dib
    EPM, UNIFESP
    Braz J Otorhinolaryngol 73:390-7. 2007
    ..Tinnitus is a common symptom, defined as a sound perception in absence of a sound stimulus...
  51. ncbi Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding
    Yuji Odagaki
    Department of Psychiatry, Saitama Medical School, Moroyama machi, Iruma gun, Saitama, Japan
    J Psychopharmacol 19:235-41. 2005
    b>Trazodone is an effective antidepressant drug with a broad therapeutic spectrum, including anxiolytic efficacy...
  52. ncbi Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares
    M D Warner
    University of Michigan Medical Center, USA
    Pharmacopsychiatry 34:128-31. 2001
    BACKGROUND: Trazodone is commonly used in the treatment of insonmia and nightmares in patients with PTSD. There is little evidence in the literature for this practice...
  53. ncbi Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes
    B Garrone
    Pharmacological Department, ACRAF Angelini Ricerche, P le della Stazione s n c, 00040 S Palomba Pomezia, Rome, Italy
    Eur J Pharmacol 400:35-41. 2000
    The effects of trazodone and putative sigma (sigma) receptor ligands were investigated on KCl-stimulated release of glutamate (Glu) and gamma-aminobutyric acid (GABA) from cerebellar mossy fibre synaptosomes...
  54. ncbi Fatal overdose with trazodone: case report and literature review
    A de Meester
    Cardiology Department, Jolimont Hospital, 7100 Haine Saint Paul, Belgium
    Acta Clin Belg 56:258-61. 2001
    A fatal case of suicide with trazodone alone in a 40-year-old patient is reported. Life-threatening arrhythmias, such as torsades de pointes and complete AV block, are recorded...
  55. ncbi Insomnia in somatoform pain disorder: sleep laboratory studies on differences to controls and acute effects of trazodone, evaluated by the Somnolyzer 24 x 7 and the Siesta database
    Bernd Saletu
    Department of Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 51:148-63. 2005
    ..Subsequent evaluation of the acute effects of 100 mg of a controlled-release formulation of trazodone (Trittico retard) in the patients demonstrated an increase in the target variable SWS, accompanied by a ..
  56. ncbi Insomnia in depression: differences in objective and subjective sleep and awakening quality to normal controls and acute effects of trazodone
    Gerda Maria Saletu-Zyhlarz
    Department of Psychiatry, University of Vienna, Austria
    Prog Neuropsychopharmacol Biol Psychiatry 26:249-60. 2002
    ..In a subsequent acute, placebo-controlled cross-over design study, the acute effects of 100 mg of trazodone, a serotonin reuptake inhibitor with a sedative action due to 5-HT2 and alpha1 receptor blockade, were ..
  57. ncbi Safety of trazodone as a sleep agent for inpatients
    Geetha Jayaram
    Department of Psychiatry, Johns Hopkins Hospital, Meyer 4 181, Baltimore, MD 21287, USA
    Psychosomatics 46:367-9. 2005
    b>Trazodone, an atypical antidepressant with relatively low anticholinergic and cardiac conduction effects, offers useful augmentation to classic antidepressant drugs, notably selective serotonin reuptake inhibitors...
  58. ncbi Electroconvulsive therapy and cardiovascular complications in patients taking trazodone for insomnia
    L E Krahn
    Mayo Sleep Disorders Center, Mayo Clinic, Rochester, Minn 55905, USA
    J Clin Psychiatry 62:108-10. 2001
    BACKGROUND: Trazodone has been used widely to treat insomnia in depressed patients. When used in combination with electroconvulsive therapy (ECT), trazodone has been suspected to cause cardiovascular side effects...
  59. ncbi Acute behavioral effects and abuse potential of trazodone, zolpidem and triazolam in humans
    C R Rush
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
    Psychopharmacology (Berl) 144:220-33. 1999
    ..examined the acute behavioral effects and abuse potential of three drugs commonly used to treat sleep disorders, trazodone, zolpidem and triazolam, and placebo in ten male volunteers with histories of alcohol and drug abuse...
  60. ncbi A comparative, randomised, double-blind study of trazodone prolonged-release and paroxetine in the treatment of patients with major depressive disorder
    S Kasper
    Department of General Psychiatry, Medical University, Vienna, Austria
    Curr Med Res Opin 21:1139-46. 2005
    To evaluate the efficacy and safety of trazodone prolonged release compared with paroxetine in the treatment of patients with major depression.
  61. ncbi Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults
    J C Ware
    Sleep Disorders Center, Sentara Norfolk General Hospital, VA 23507
    J Clin Psychiatry 51:18-22. 1990
    The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men...
  62. ncbi Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients
    Lucie Zavesicka
    Prague Psychiatric Center, 3rd Faculty of Medicine, Charles University, Ustavni 91, 181 03 Praha 8 Bohnice, Czech Republic
    Neuro Endocrinol Lett 29:895-901. 2008
    ..The present study was undertaken to evaluate the clinical efficacy of CBT, singly and combined with trazodone pharmacotherapy, for primary insomnia.
  63. ncbi A meta-analysis of clinical trials comparing the serotonin (5HT)-2 receptor antagonists trazodone and nefazodone with selective serotonin reuptake inhibitors for the treatment of major depressive disorder
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
    Eur Psychiatry 22:444-7. 2007
    ..To compare response rates among patients with major depressive disorder (MDD) treated with either a serotonin-2 (5HT2-) receptor antagonist or a selective serotonin reuptake inhibitor (SSRI)...
  64. ncbi The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog
    S C Veasey
    Center for Sleep and Respiratory Neurobiology, Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine University of Pennsylvania, Philadelphia, USA
    Am J Respir Crit Care Med 160:1659-67. 1999
    ..multidose, randomized sleep studies testing the effectiveness of a combination of serotoninergics, trazodone, and L-tryptophan, in our animal model of OSAHS, the English bulldog...
  65. ncbi Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients
    K Mihara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan
    Pharmacol Toxicol 88:267-70. 2001
    ..a genetic polymorphism of inducibility of cytochrome P450 (CYP) 1A2 on the steady-state plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, were studied in order to clarify if these steady-state ..
  66. ncbi Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult mice
    S Y Hsiao
    Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Chin J Physiol 48:223-9. 2005
    ..whether prenatal exposure of four frequently-used antidepressants, bupropion, fluvoxamine, citalopram, and trazodone, altered the responsiveness to stress and cocaine in the adulthood...
  67. ncbi [Review of antidepressants from the TCAs to the third generation drugs]
    János Almási
    Organon Hungary Kft, Orvosi Osztály, Budapest
    Neuropsychopharmacol Hung 6:185-94. 2004
    ..The main aim of this review is to give an objective approach to the psychiatrists in order to choose the best and optimal pharmaco-therapeutical method in their daily practice...
  68. ncbi [Trazodone and venlafaxine in treatment of depressive disorders]
    Antoni Florkowski
    Klinika Psychiatrii i Zaburzeń Nerwicowych z Oddziałem Interwencji Kryzysowych Uniwersytetu Medycznego w Lodzi
    Pol Merkur Lekarski 18:556-9. 2005
    ..The aim of the study was to evaluate trazodone efficiency and safety in comparison to venlafaxine treatments of depressive episode, recurrent depressive ..
  69. ncbi Prolonged QT associated with an overdose of trazodone
    Philip B Dattilo
    J Clin Psychiatry 68:1309-10. 2007
  70. ncbi [Review of pharmacological efficacies and side effects of antidepressants]
    Atsuko Ikenouchi-Sugita
    Department of Psychiatry, University of Occupational and Environmental Health
    Nihon Rinsho 65:1633-7. 2007
    ..Tricyclic antidepressants are still important for treating severe depression, and mianserin and trazodone are useful for treating delirium...
  71. ncbi Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice
    Kuo Pyng Shen
    Department and Graduate Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    J Pharm Pharmacol 57:117-25. 2005
    ..Intravenous administration of eugenosedin-A, trazodone, yohimbine (1 mg kg(-1)), aminoguanidine or ascorbic acid (15 mg kg(-1)) normalized LPS (10 mg kg(-1))-induced ..
  72. ncbi Therapeutic drug monitoring of non-tricyclic antidepressant drugs
    Philip B Mitchell
    School of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, Australia
    Clin Chem Lab Med 42:1212-8. 2004
    ..serotonin reuptake inhibitors (SSRIs) and other non-tricyclic antidepressants such as venlafaxine, nefazodone, trazodone, mianserin and bupropion...
  73. ncbi A case of prolonged peyote-induced psychosis resolved by sleep
    Brett Y Lu
    J Clin Psychiatry 65:1433-4. 2004
  74. ncbi Using metaanalysis to evaluate evidence: practical tips and traps
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:167-74. 2005
    ..This paper focuses on basic principles and terms used in metaanalysis, so that clinicians can appropriately evaluate and use their results to guide treatment decisions...
  75. ncbi Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content
    Radivoj Jadrić
    Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 7:222-5. 2007
    ..Brain beta-endorphins were higher in experiment group treated with trazodone (929 pg/g +/- 44,43; X+/-SD), and dibenzepine (906,63 pg/g +/- 74,06), yet with lower brain content in rats ..
  76. ncbi The management of insomnia in the older adult
    Ana C Tuya
    Rhode Island Hospital, The Warren Alpert Medical School of Brown University, USA
    Med Health R I 90:195-6. 2007
  77. ncbi The four-plates test: anxiolytic or analgesic paradigm?
    Nadège Ripoll
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Prog Neuropsychopharmacol Biol Psychiatry 30:873-80. 2006
    ..Our results suggest that the reported drug-induced anti-punishment effects in the FPT are not related to modifications of pain threshold but to a pure anxiolytic-like effect...
  78. ncbi Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression
    Fady Rachid
    Division of Adult Psychiatry, University Hospitals of Geneva, Switzerland
    World J Biol Psychiatry 7:261-4. 2006
    ..Therefore, caution should be exercised among clinicians using this experimental procedure, particularly in the treatment of bipolar depressed patients...
  79. ncbi Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Japan
    J Pharmacol Sci 102:278-87. 2006
    ..However, two structurally different antidepressants: milnacipran and trazodone, caused only a small inhibition of basal GIRK currents. Additionally, Kir1.1 and Kir2...
  80. ncbi Noradrenergic and serotonergic modulation to treat vasomotor symptoms
    Paola Albertazzi
    Centre for Metabolic Bone Disease, Hull Royal Infirmary, Hull, UK
    J Br Menopause Soc 12:7-11. 2006
    ..Thus, non-hormonal treatments are not as effective as estrogens in relieving hot flushes but may have a place as an alternative...
  81. ncbi A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers
    Louise M Paterson
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Psychopharmacology (Berl) 191:943-50. 2007
    ..Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate animal models to assess likely outcome in the clinic...
  82. ncbi Pharmacological treatment of insomnia for individuals with brain injury
    Steven R Flanagan
    Departments of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Head Trauma Rehabil 22:67-70. 2007
  83. ncbi A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder
    Mary E Becker
    Durham VA Medical Center, NC 27705, USA
    J Clin Psychopharmacol 27:193-7. 2007
    ....
  84. ncbi A rational combination pharmacotherapy in men with erectile dysfunction who initially failed to oral sildenafil citrate alone: a pilot study
    Rajesh Taneja
    Pushpawati Singhania Research Institute Surgical Division, New Delhi, India
    J Sex Med 4:1136-41. 2007
    ..A combination of trazodone with sildenafil has been used to overcome both organic as well as psychogenic components, thus improving the ..
  85. ncbi Current patterns and future directions in the treatment of insomnia
    John Winkelman
    Sleep Disorders Program, Brigham and Women s Hospital, Sleep Health Center, Newton, MA 02459, USA
    Ann Clin Psychiatry 17:31-40. 2005
    ..Despite the high prevalence and the high burden associated with chronic insomnia, it remains largely unrecognized and often inadequately treated by physicians...
  86. ncbi Low-dose-trazodone-induced disorganized type psychosis
    Yoshito Mizoguchi
    J Neuropsychiatry Clin Neurosci 17:253-4. 2005
  87. ncbi "A comparison of the effectiveness of two hypnotic agents for the treatment of insomnia"
    Thomas Schwartz
    SUNY Upstate Medical University, Department of Psychiatry, 750 East Adams Street, Syracuse, NY 13210, USA
    Int J Psychiatr Nurs Res 10:1146-50. 2004
    ..To compare the effectiveness and tolerability of two hypnotic agents, trazadone (Desyrel) and zaleplon (Sonata) on psychiatric inpatients with insomnia...
  88. ncbi Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone
    Edgar Zitron
    Department of Internal Medicine III Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, 69115, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 370:146-56. 2004
    b>Trazodone is an atypical antidepressant that is commonly used in the treatment of affective disorders...
  89. ncbi Studies on the anti-inflammatory effect of fluoxetine in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 49:119-31. 2004
    ..In contrast, administration of both fluoxetine and the heterocyclic antidepressant trazodone had no greater anti-inflammatory effect than fluoxetine alone...
  90. ncbi [Chronobiological research on antidepressant drugs: the effect of the antidepressant drugs, trazodone and imipramine on the circadian rhythm using electroencephalography in healthy volunteers]
    Shuichi Nakamura
    Department of Neuropsychiatry, Nippon Medical School, Japan
    J Nippon Med Sch 69:262-7. 2002
    The effects of the antidepressant drugs trazodone and imipramine on the circadian rhythm were studied by means of the sleep propensity test (SPT; sleep latency was examined by 35-minute EEG records at 09:00, 11:00, 13:00, 15:00, 17:00)...
  91. ncbi [Interest of the use of pindolol in the treatment of depression: review]
    G Brousse
    CMPB, Service de Psychiatrie Adulte, CHU, rue Montalembert, 63003 Clermont Ferrand
    Encephale 29:338-50. 2003
    ..Three studies were carried out with fluoxetine, 1 with fluvoxamine, 3 with paroxetine, 1 with trazodone. Two -studies were investigated with several antidepressant treatments...
  92. ncbi Confirmation of the neurophysiologically predicted therapeutic effects of trazodone on its target symptoms depression, anxiety and insomnia by postmarketing clinical studies with a controlled-release formulation in depressed outpatients
    Gerda Maria Saletu-Zyhlarz
    Department of Psychiatry, University of Vienna, Vienna, Austria
    Neuropsychobiology 48:194-208. 2003
    Early human pharmaco-EEG and subsequent sleep laboratory studies identified trazodone, a 5-HT(2) antagonist and 5-HT reuptake inhibitor (SARI), as an antidepressant with therapeutic effects on its target symptoms depressed mood, anxiety ..
  93. ncbi [Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias]
    Florence Lebert
    Centre Médical des Monts de Flandres, Centre de la Mémoire, CHRU Lille, Bailleul
    Presse Med 32:1181-6. 2003
    ....
  94. pmc Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
    Maher Karam-Hage
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48108, USA
    Psychiatry Clin Neurosci 57:542-4. 2003
    Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ)...
  95. ncbi Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone
    S Hatsuda
    Department of Neuropsychiatry, Aichi Medical College, Nagakute, Japan
    Neuropsychobiology 44:103-7. 2001
    ..In rats given trazodone, m-chlorophenylpiperazine dihydrochloride, or imipramine, the concentrations of 5-HT were unchanged...
  96. ncbi Double-blind, placebo-controlled study of the efficacy of trazodone in alcohol post-withdrawal syndrome: polysomnographic and clinical evaluations
    Olivier Le Bon
    Brugmann University Hospital, CHU Brugmann S78, Universite Libre de Bruxelles, 1040 Brussels, Belgium
    J Clin Psychopharmacol 23:377-83. 2003
    ..In this report, we evaluated the capacity of trazodone (TRZ), a second-generation antidepressant with anxiolytic and sedative properties, to increase the sleep ..
  97. ncbi Myoclonus secondary to the concurrent use of trazodone and fluoxetine
    W Darko
    Department of Pharmacy Services, University Hospital, Syracuse, New York 13210, USA
    Vet Hum Toxicol 43:214-5. 2001
    ..Prior to admission, he was on 50 mg trazodone every evening for 2 mo for depression...
  98. ncbi Effects of trazodone and imipramine on the biological rhythm: an analysis of sleep EEG and body core temperature
    Hideaki Suzuki
    Department of Neuropsychiatry, Nippon Medical School, Japan
    J Nippon Med Sch 69:333-41. 2002
    ..Therefore, we have undertaken a study on the direct effects of the antidepressants trazodone and imipramine on the biological rhythms of healthy volunteers...
  99. ncbi Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis
    R Waschgler
    Medical Central Laboratory, Feldkirch, Austria
    Int J Clin Pharmacol Ther 40:554-9. 2002
    ..clozapine (leponex), fluoxetine (fluctine), norfluoxetine, maprotiline (ludiomil), desmethylmaprotiline and trazodone (trittico) in human serum within a period of 11.5 minutes using reversed phase HPLC...
  100. ncbi The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists
    Christina M Dording
    Depression Clinical and Research Group, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Clin Psychiatry 14:143-7. 2002
    ..120/330) opted to switch agents as their first choice; for SSRI-induced insomnia, 78% (264/326) chose adding trazodone. Switching agents was the first choice of 61% (214/353) of clinicians for managing SSRI-induced agitation, 93% (..
  101. ncbi Dissociative symptoms from combined treatment with sertraline and trazodone
    Timothy Lacy
    J Neuropsychiatry Clin Neurosci 15:241-2. 2003

Research Grants29

  1. INSOMNIA AND DRUG RELAPSE RISK
    Michael Stein; Fiscal Year: 2009
    ..b>Trazodone, an F.D.A...
  2. Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
    ABDUL SANKRI-TARBICHI; Fiscal Year: 2013
    ..Hypothesis (3a): Buspirone (5-HT1A agonist) widens the CO2 reserve in SCI patients. Hypothesis (3b): Trazodone (5-HT2C agonist) widens the CO2 reserve in SCI patients...
  3. Medications and the Risk of Sudden Cardiac Death
    Wayne A Ray; Fiscal Year: 2013
    ..torsade de pointes suggest four specific widely used antidepressants--fluoxetine, citalopram, escitalopram, and trazodone--may increase risk of sudden cardiac death...
  4. Rehabilitation of Stress-Induced Insomnia
    Pingfu Feng; Fiscal Year: 2009
    ..objectives to separately study how the drugs eszopiclone (Lunesta, a non-benzodiazepine GABAergic agonist) and trazodone (a commonly prescribed antidepressant used for insomnia) affect sleep in acute (two days) treatment and chronic ..
  5. 1/2-Sequenced Therapies for Comorbid and Primary Insomnias
    Jack D Edinger; Fiscal Year: 2013
    ..first-line therapy will be encouraged to accept random assignment to a second, 6-week, medication (zolpidem or trazodone) or behavioral (standard or tailored CBT) treatment...
  6. 2/2-Sequenced Therapies for Comorbid and Primary Insomnias
    Charles M Morin; Fiscal Year: 2013
    ..first-line therapy will be encouraged to accept random assignment to a second, 6-week, medication (zolpidem or trazodone) or behavioral (standard or tailored CBT) treatment...
  7. Next-day Behavioral Effects of Trazodone
    Anthony Liguori; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Trazodone, the most widely used sleep aid in the U.S., is indicated for depression, and is not indicated for insomnia...
  8. Medication Effects on Sleep in Alcoholics
    Kirk Brower; Fiscal Year: 2009
    ..two medications with known potential for treating either alcohol dependence or insomnia (gabapentin, trazodone) will be studied for their short-term effects on disregulated sleep in alcohol-dependent patients...
  9. Trazodone for Sleep Disturbance - Early Alcohol Recovery
    Peter Friedmann; Fiscal Year: 2004
    ..b>Trazodone, an F.D.A...
  10. Stabilize Addiction/Affect, Begin Inmates' Interferon for HCV of Liver (STAABIHL)
    Peter Friedmann; Fiscal Year: 2009
    ..Such increased access to therapy would benefit public health and public safety. ..
  11. LINKAGE TO HEALTH SERVICES IN DRUG ABUSE TREATMENT
    Peter Friedmann; Fiscal Year: 2002
    ..This work will improve our understanding of linkage mechanisms and of problem-service matching, and quantify the extent to which medical and psychosocial services are important components of effective drug abuse treatment. ..
  12. Abuse Liability Associated with Chronic Hypnotic Use
    Timothy Roehrs; Fiscal Year: 2008
    ....
  13. PGP Regulation of Antipsychotic Exposure and Effects
    C Devane; Fiscal Year: 2008
    ..The results of this research will provide support for translational studies in humans to refine treatment guidelines for the use of this class of medications in severely mentally ill patients. ..
  14. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  15. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  16. SLEEPINESS AND THE REINFORCING EFFECT OF METHYLPHENIDATE
    Timothy Roehrs; Fiscal Year: 2002
    ..And finally during year five the interaction of behavioral demand placed on subjects and different levels of sleepiness-alertness will be the focus. ..
  17. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  18. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  19. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  20. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  21. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2004
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  22. Insomnia as a Path to Alcohol Abuse
    Timothy Roehrs; Fiscal Year: 2005
    ..abstract_text> ..
  23. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  24. Exercise & Health Promotion for MCI: A Controlled Trial
    Linda Teri; Fiscal Year: 2010
    ..These older adults are at increased risk of developing Alzheimer's disease within 3 years, and delaying or preventing cognitive decline will preserve their ability to live independently and save public health dollars. ..
  25. S-Adenosyl Methionine(SAMe)Augmentation of SSRIs in MDD
    George Papakostas; Fiscal Year: 2008
    ..It is hoped that this project award will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator in this area. ..
  26. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  27. Improving Affect & Behavior in Assisted Living Residents
    Linda Teri; Fiscal Year: 2006
    ..Finally, the results of this trial will be used to develop a multi-site effectiveness trial on treatment to reduce affective and behavioral disturbance in AL residents with dementia. ..