ranitidine

Summary

Summary: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Top Publications

  1. ncbi Anaphylactic reaction to ranitidine and dexchlorpheniramine
    C Thurot-Guillou
    Eur J Dermatol 17:170-1. 2007
  2. ncbi A systematic comparison of triple therapies for treatment of Helicobacter pylori infection with proton pump inhibitor/ ranitidine bismuth citrate plus clarithromycin and either amoxicillin or a nitroimidazole
    M J Janssen
    Department of Gastroenterology and Hepatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 15:613-24. 2001
  3. ncbi Drug-drug interaction between diclofenac, cetirizine and ranitidine
    Ihsan M Kenawi
    Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
    J Pharm Biomed Anal 37:655-61. 2005
  4. ncbi Randomized study comparing omeprazole with ranitidine as anti-secretory agents combined in quadruple second-line Helicobacter pylori eradication regimens
    S Michopoulos
    Gastroenterology Unit, Alexandra University Hospital, Athens, Greece
    Aliment Pharmacol Ther 14:737-44. 2000
  5. ncbi Retreatment of Helicobacter pylori infection after initial treatment failure
    D J Kearney
    Gastroenterology Section, University of Washington, VA Puget Sound Health Care System, Seattle, USA
    Am J Gastroenterol 96:1335-9. 2001
  6. ncbi A randomized trial comparing omeprazole, ranitidine, cisapride, or placebo in helicobacter pylori negative, primary care patients with dyspepsia: the CADET-HN Study
    Sander J O Veldhuyzen van Zanten
    Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Gastroenterol 100:1477-88. 2005
  7. ncbi Ranitidine reduces ischemia/reperfusion-induced liver injury in rats by inhibiting neutrophil activation
    Kenji Okajima
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 0811, Japan
    J Pharmacol Exp Ther 301:1157-65. 2002
  8. ncbi Histamine H2-receptor antagonist ranitidine protects against neural death induced by oxygen-glucose deprivation
    Cristina Malagelada
    Institut de Neurociènces and Unitat de Bioquímica de Medicina, Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Stroke 35:2396-401. 2004
  9. ncbi Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 80:203-13. 2004
  10. ncbi Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride
    H Kortejärvi
    Orion Pharma, Research and Development, Espoo, Finland
    J Pharm Sci 94:1617-25. 2005

Research Grants

  1. Regulation of Drug Metabolizing Enzyme Ontogeny
    Ronald N Hines; Fiscal Year: 2010
  2. Regulation of Drug Metabolizing Enzyme Ontogeny
    RONALD HINES; Fiscal Year: 2009
  3. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
  4. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2010
  5. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2009
  6. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
  7. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2009
  8. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2004
  9. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2010
  10. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2010

Detail Information

Publications209 found, 100 shown here

  1. ncbi Anaphylactic reaction to ranitidine and dexchlorpheniramine
    C Thurot-Guillou
    Eur J Dermatol 17:170-1. 2007
  2. ncbi A systematic comparison of triple therapies for treatment of Helicobacter pylori infection with proton pump inhibitor/ ranitidine bismuth citrate plus clarithromycin and either amoxicillin or a nitroimidazole
    M J Janssen
    Department of Gastroenterology and Hepatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Aliment Pharmacol Ther 15:613-24. 2001
    Triple therapies with proton pump inhibitor/ranitidine bismuth citrate (RBC), clarithromycin (C) and either amoxicillin (A) or a nitroimidazole (I) are widely accepted as treatment for Helicobacter pylori infection...
  3. ncbi Drug-drug interaction between diclofenac, cetirizine and ranitidine
    Ihsan M Kenawi
    Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
    J Pharm Biomed Anal 37:655-61. 2005
    The interactions between diclofenac (1), cetirizine (2) and ranitidine (3) were investigated by thermal analyses and UV, IR and (1)H NMR spectroscopic studies...
  4. ncbi Randomized study comparing omeprazole with ranitidine as anti-secretory agents combined in quadruple second-line Helicobacter pylori eradication regimens
    S Michopoulos
    Gastroenterology Unit, Alexandra University Hospital, Athens, Greece
    Aliment Pharmacol Ther 14:737-44. 2000
    ..Few data are available on the efficacy of second-line H. pylori eradication regimens...
  5. ncbi Retreatment of Helicobacter pylori infection after initial treatment failure
    D J Kearney
    Gastroenterology Section, University of Washington, VA Puget Sound Health Care System, Seattle, USA
    Am J Gastroenterol 96:1335-9. 2001
    ..pylori infection remains limited. The existing data support the use of bismuth-based quadruple therapy or ranitidine bismuth citrate (RBC)-based triple therapy as the preferred agents after initial treatment failure...
  6. ncbi A randomized trial comparing omeprazole, ranitidine, cisapride, or placebo in helicobacter pylori negative, primary care patients with dyspepsia: the CADET-HN Study
    Sander J O Veldhuyzen van Zanten
    Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Gastroenterol 100:1477-88. 2005
    ..The management of Helicobacter pylori negative patients with dyspepsia in primary care has not been studied in placebo-controlled studies...
  7. ncbi Ranitidine reduces ischemia/reperfusion-induced liver injury in rats by inhibiting neutrophil activation
    Kenji Okajima
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 0811, Japan
    J Pharmacol Exp Ther 301:1157-65. 2002
    We previously reported that ranitidine, an H(2) receptor antagonist, inhibited neutrophil activation in vitro and in vivo, contributing to reduce stress-induced gastric mucosal injury in rats...
  8. ncbi Histamine H2-receptor antagonist ranitidine protects against neural death induced by oxygen-glucose deprivation
    Cristina Malagelada
    Institut de Neurociènces and Unitat de Bioquímica de Medicina, Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Stroke 35:2396-401. 2004
    ..In this study, we investigated the neuroprotective effects of histamine H2-receptor antagonists in an "in vitro" model of ischemia...
  9. ncbi Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 80:203-13. 2004
    ..inflammation can precipitate idiosyncratic-like liver injury from the histamine 2-receptor antagonist, ranitidine (RAN)...
  10. ncbi Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride
    H Kortejärvi
    Orion Pharma, Research and Development, Espoo, Finland
    J Pharm Sci 94:1617-25. 2005
    ..of in vivo bioequivalence testing for the approval of immediate release (IR) solid oral dosage forms containing ranitidine hydrochloride are reviewed...
  11. ncbi Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
    David L Bourdet
    Division of Drug Delivery and Disposition, School of Pharmacy, Kerr Hall, CB 7360, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Pharmacol Exp Ther 315:1288-97. 2005
    ..The purpose of this study was to evaluate the substrate and inhibitory activity of the H2-receptor antagonists ranitidine and famotidine toward hOCTs and to determine the hOCT isoforms involved in the absorption and elimination of ..
  12. ncbi Six-month management of patients following treatment for gastroesophageal reflux disease symptoms -- a Norwegian randomized, prospective study comparing the costs and effectiveness of esomeprazole and ranitidine treatment strategies in a general medical p
    A N Hansen
    Harbitzallèen Legesenter, Oslo, Norway
    Int J Clin Pract 59:655-64. 2005
    ..with esomeprazole 20 mg, continuous treatment with esomeprazole 20 mg once-daily and continuous treatment with ranitidine 150 mg twice-daily to prevent symptomatic relapse in patients with gastroesophageal reflux disease over 26 weeks...
  13. ncbi Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs
    Alexa M E Bersenas
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Vet Res 66:425-31. 2005
    ..To identify the normal gastric acid secretion profile in dogs and determine the degree of gastric acid suppression associated with 4 gastric acid suppressants...
  14. ncbi Seven-day 'rescue' therapy after Helicobacter pylori treatment failure: omeprazole, bismuth, tetracycline and metronidazole vs. ranitidine bismuth citrate, tetracycline and metronidazole
    J P Gisbert
    Department of Gastroenterology, University Hospital of La Princesa, Madrid, Spain
    Aliment Pharmacol Ther 13:1311-6. 1999
    ..A 'rescue' therapy with a quadruple combination of O, bismuth (B), tetracycline (T) and metronidazole (M) has been recommended...
  15. ncbi Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers
    Kiho Lee
    Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Pharmacol Exp Ther 303:574-80. 2002
    The secretory transport of the H(2)-antagonists, ranitidine and famotidine, across Caco-2 cell monolayers was found to be a saturable process...
  16. ncbi Ranitidine (Zantac) syrup versus Ranitidine effervescent tablets (Zantac) EFFERdose) in children: a single-center taste preference study
    Vanessa Z Ameen
    Clinical Pharmacology and Discovery Medicine, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Paediatr Drugs 8:265-70. 2006
    The histamine H(2) receptor antagonist ranitidine is US FDA-approved for the treatment of gastroesophageal reflux disease and healing of erosive esophagitis in children >or=1 month of age...
  17. doi Attenuation of stress-induced gastric lesions by lansoprazole, PD-136450 and ranitidine in rats
    S I Chandranath
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Mol Cell Biochem 349:205-12. 2011
    ..activities of lansoprazole (a proton pump inhibitor), PD-136450 (CCK(2)/gastrin receptor antagonist) and ranitidine (histamine H(2) receptor antagonist) on CRS-induced gastric ulcers in rats...
  18. ncbi A modified two-portion absorption model to describe double-peak absorption profiles of ranitidine
    Ophelia Q P Yin
    School of Pharmacy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Clin Pharmacokinet 42:179-92. 2003
    ..The pharmacokinetics of oral drugs exhibiting double peaks cannot be adequately described by using conventional compartmental models...
  19. ncbi Effects of a single low dose of ranitidine and effervescent antacids on intragastric acidity in healthy volunteers
    Rafael Améndola
    Investigación Gastroenterológica Asociación Civil, Buenos Aires, Argentina
    Acta Gastroenterol Latinoam 37:231-7. 2007
    We hypothesized that a combination of an effervescent antacid and ranitidine could allow immediate and long-lasting increase intragastric acidity...
  20. doi Clinical trial: intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: a multicentre, multinational, randomized trial
    C van Rensburg
    Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa
    Aliment Pharmacol Ther 29:497-507. 2009
    ..Controlled pantoprazole data in peptic ulcer bleeding are few...
  21. doi Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis
    Hae Jeong Park
    Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    Neurotoxicology 30:1114-9. 2009
    ..In this study, we investigated the protective effects of the H(2) receptor antagonist ranitidine on rotenone-induced apoptosis in human dopaminergic SH-SY5Y cells, focusing on mitogen-activated protein kinases ..
  22. doi Statistical optimization of ranitidine HCl floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough
    Pallab Roy
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Ahmedabad, C o B V Patel Pharmaceutical Education and Research Development PERD Centre, Sarkhej Gandhinagar Highway, Thaltej, Gujarat, India
    Eur J Pharm Sci 37:363-9. 2009
    ..This approach will be achieved by using a programmed delivery of ranitidine hydrochloride from a floating tablet with time-lagged coating...
  23. ncbi Effects of the selective H1 and H2 histamine receptor antagonists loratadine and ranitidine on autonomic control of the heart
    Michael A Nault
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Anesthesiology 96:336-41. 2002
    ..This study was designed to investigate the effects of the selective H1 and H2 receptor antagonists loratadine and ranitidine on physiologic autonomic control of the healthy cardiovascular system.
  24. doi The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials
    K Clark
    Cunningham Centre for Palliative Care, The University of Notre Dame, Darlinghurst, NSW, Australia
    Anaesthesia 64:652-7. 2009
    ..Electronic databases were searched for trials that compared ranitidine vs proton pump inhibitors in their effect on volume and pH of gastric fluid aspirates...
  25. ncbi Dose reduction of steroid premedication for paclitaxel: no increase of hypersensitivity reactions
    H Koppler
    Praxis für Hämatologie und Onkologie, Neverstrasse 5, D 56058 Koblenz, Germany
    Onkologie 24:283-5. 2001
    Premedication with dexamethasone, ranitidine and clemastine is mandatory for patients receiving paclitaxel to avoid hypersensitivity reactions. The proposed dexamethasone dose is 20 mg orally 12 and 6 h prior to paclitaxel infusion...
  26. ncbi [Randomized, open label study on the use of ranitidine at different doses for the management of weight gain associated with olanzapine administration]
    Andrea Lopez-Mato
    Instituto de Psiquiatría Biológica Integral, Buenos Aires, Argentina
    Vertex 14:85-96. 2003
    ..In this study, concomitant administration of Ranitidine prevented or corrected weight gain in 59.6% of cases...
  27. doi Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment
    Emel Ozturk
    Department of Nuclear Medicine, Ufuk University Medical School, Gulhane Military Medical Academy and Medical School, Ankara, Turkey
    J Gastroenterol Hepatol 24:1248-51. 2009
    ..We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications...
  28. ncbi Effect of H. pylori status on gastric ulcer healing in patients continuing nonsteroidal anti-inflammatory therapy and receiving treatment with lansoprazole or ranitidine
    Donald R Campbell
    Department of Medicine, VAMC, Kansas City, Missouri, USA
    Am J Gastroenterol 97:2208-14. 2002
    ..The purpose of this research was to determine the impact of pretreatment Helicobacter pylori infection on gastric ulcer healing rates in patients receiving nonsteroidal anti-inflammatory drugs (NSAIDs) and antisecretory medications...
  29. ncbi Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats
    James P Luyendyk
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hepatology 40:1342-51. 2004
    Coadministration of nonhepatotoxic doses of the histamine 2-receptor antagonist ranitidine (RAN) and bacterial lipopolysaccharide (LPS) results in hepatocellular injury in rats, the onset of which occurs in 3 to 6 hours...
  30. ncbi One-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline effectively eradicate Helicobacter pylori: a multicentre, randomized, double-blind study
    H Lu
    Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai, China
    Aliment Pharmacol Ther 15:1975-9. 2001
    ..AIM: To evaluate the efficacy and safety of new 1-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline...
  31. doi Effect of gastric emptying and entero-hepatic circulation on bioequivalence assessment of ranitidine
    J Chrenova
    Slovak University of Technology, Slovak Academy of Science, Bratislava, Slovakia
    Methods Find Exp Clin Pharmacol 32:413-9. 2010
    The aim of study was to compare the bioavailability of ranitidine obtained from either Ranitidine (300 mg tablet; LPH® S.C. LaborMed Pharma S.A...
  32. ncbi A comparison of two prophylactic regimens for hypersensitivity reactions to paclitaxel
    Janice S Kwon
    Division of Gynecologic Oncology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Gynecol Oncol 84:420-5. 2002
    ....
  33. ncbi The efficacy of lafutidine in improving preoperative gastric fluid property: a comparison with ranitidine and rabeprazole
    Takanobu Uesugi
    Department of Anesthesia and Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki cho 7, Chuo Ku, Kobe 650 0017, Japan
    Anesth Analg 95:144-7, table of contents. 2002
    Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that ..
  34. ncbi Ranitidine-induced anaphylaxis: detection of serum specific IgE antibody
    Y I Koh
    Department of Allergy, Chonnam National University Medical School, 8 Hak Dong, Dong Ku, Gwangju 501 757, Republic of Korea
    Allergy 61:269-70. 2006
  35. ncbi Bioadhesive ranitidine hydrochloride for gastroretention with controlled microenvironmental pH
    Anuradha Adhikary
    Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology, Matunga E, Mumbai, Maharashtra, India
    Drug Dev Ind Pharm 34:860-9. 2008
    b>Ranitidine hydrochloride is a H(2) receptor blocker used in the treatment of gastric ulcers...
  36. doi Effects of the H2-receptor antagonist ranitidine on gastric motor function after a liquid meal in healthy humans
    Jan Lysgård Madsen
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Scand J Clin Lab Invest 68:681-4. 2008
    ..This study examined the effect of ranitidine, an H(2)-receptor antagonist, on gastric volume and gastric emptying after a liquid meal in healthy humans.
  37. ncbi Effect of milling conditions on the solid-state conversion of ranitidine hydrochloride form 1
    N Chieng
    School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
    Int J Pharm 327:36-44. 2006
    Powder samples of ranitidine hydrochloride forms 1 and 2 were milled using a vibrational ball mill (Retsch MM301) for periods up to 240min at 4, 12 and 35 degrees C...
  38. ncbi Effects of three H2-receptor antagonists (cimetidine, famotidine, ranitidine) on serum gastrin level
    T Ohsawa
    Chidoribashi Hospital Pharmacy, Department of Pharmacokinetics, Faculty of Pharmaceutical Science, Kyushu University, Fukuoka, Japan
    Int J Clin Pharmacol Res 22:29-35. 2002
    ..The subjects were 51 patients (cimetidine: 18 patients; famotidine: 16 patients; ranitidine: 17 patients)...
  39. ncbi Simultaneous determination of cimetidine, famotidine, nizatidine, and ranitidine in tablets by capillary zone electrophoresis
    S M Wu
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, ROC, Taiwan
    Electrophoresis 22:2758-62. 2001
    ..is described for the simultaneous determination of cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine (RAN). The analysis of these drugs was performed in a 100 mM phosphate buffer, pH 3.5...
  40. ncbi Subtleties in crystal structure solution from powder diffraction data using simulated annealing: ranitidine hydrochloride
    Ashfia Huq
    Department of Physics and Astronomy, State University of New York at Stony Brook, Stony Brook, New York 11794 3800, USA
    J Pharm Sci 92:244-9. 2003
    ..We use ranitidine HCl as our test sample as it is known to have a conformational disorder from single crystal structural work...
  41. doi Polyethylene glycol 400 enhances the bioavailability of a BCS class III drug (ranitidine) in male subjects but not females
    Diane A I Ashiru
    Department of Pharmaceutics, The School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, United Kingdom
    Pharm Res 25:2327-33. 2008
    The aim of this study was to investigate the effects of different doses of polyethylene glycol 400 (PEG 400) on the bioavailability of ranitidine in male and female subjects.
  42. ncbi Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats
    Elif Cadirci
    Ataturk University, Faculty of Pharmacy, Department of Pharmacology, 25240, Erzurum, Turkey
    Chem Biol Interact 170:40-8. 2007
    ..We found that 50, 100 and 200 mg/kg doses of AR-1 inhibited ulcers more effectively than did ranitidine. AR-1 at doses of 25, 50, 100 and 200 mg/kg significantly prevented the decrease in total glutathione (tGSH) ..
  43. ncbi Gastrin stimulates the self-replication rate of enterochromaffinlike cells in the rat stomach. Effects of omeprazole, ranitidine, and gastrin-17 in intact and antrectomized rats
    B Ryberg
    AB Hässle, Department of Biology, Molndal, Sweden
    Gastroenterology 99:935-42. 1990
    ..kg-1.day-1) or ranitidine (1200 mumol.kg-1.day-1). The effect of omeprazole was also studied in antrectomized rats...
  44. ncbi Systematic review and meta-analysis: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics in Helicobacter pylori eradication
    Javier P Gisbert
    Department of Gastroenterology, University Hospital of La Princesa, Madrid, Spain
    Helicobacter 10:157-71. 2005
    To systematically review the Helicobacter pylori eradication efficacy with ranitidine bismuth citrate (RBC) and two antibiotics, and to conduct a meta-analysis of randomized clinical trials comparing the efficacy of proton pump inhibitor (..
  45. doi In vitro and in vivo evaluation of ranitidine hydrochloride loaded hollow microspheres in rabbits
    Yu Meng Wei
    Research Laboratory of Pharmaceutical Chemistry and Biomaterials, School of Pharmacy, Chongqing Medical University, No 1, Yixue Yuan Road, Chongqing 400016, PR China
    Arch Pharm Res 31:1369-77. 2008
    ..Hollow microspheres containing ranitidine hydrochloride (RH) were prepared by a novel solvent diffusion-evaporation method using ethyl cellulose (EC) ..
  46. doi Evaluation of the effect of ranitidine on gastroduodenal contractile activity and gastric emptying in horses
    Omar Maher
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 69:1153-7. 2008
    To determine the effect of ranitidine on gastric emptying in horses.
  47. ncbi Synergistic and antagonistic pharmacodynamic interaction between ranitidine and cisapride: a study on the isolated rabbit intestine
    M Koutsoviti-Papadopoulou
    Department of Pharmacology, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Greece
    Pharmacol Res 43:329-34. 2001
    The present study examines the pharmacodynamic interaction between the H(2)-receptor antagonist ranitidine and the prokinetic agent cisapride on the isolated rabbit intestine...
  48. ncbi Superiority of lansoprazole vs ranitidine in healing nonsteroidal anti-inflammatory drug-associated gastric ulcers: results of a double-blind, randomized, multicenter study. NSAID-Associated Gastric Ulcer Study Group
    N M Agrawal
    Department of Medicine, University of Connecticut Health Center, Farmington, USA
    Arch Intern Med 160:1455-61. 2000
    ..The usefulness of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by adverse gastrointestinal tract events...
  49. ncbi Ranitidine, 75 mg, over-the-counter dose: pharmacokinetic and pharmacodynamic effects in children with symptoms of gastro-oesophageal reflux
    S R Orenstein
    Pediatric Gastroenterology, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Aliment Pharmacol Ther 16:899-907. 2002
    ..However, the pharmacokinetic and pharmacodynamic effects of over-the-counter histamine-2 receptor antagonists in the paediatric population are largely unknown...
  50. ncbi Conductimetric determination of phenylpropanolamine HCl, ranitidine HCl, hyoscyamine HBr and betaine HCl in their pure state and pharmaceutical preparations
    Yousry M Issa
    Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
    Farmaco 60:541-6. 2005
    ..Cl), ranitidine HCl (Ra.Cl), hyoscyamine HBr (Hy.Br) and betaine HCl (Be.Cl) through ion-associate complex formation...
  51. ncbi Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate
    U G Meneghelli
    Division of Gastroenterology, Department of Medicine, Medical School of Ribeirao Preto, Brazil
    Dis Esophagus 15:50-6. 2002
    ..were randomly assigned to a double-blind, double-dummy treatment with either pantoprazole 40 mg once daily or ranitidine 150 mg twice daily. After 4 weeks, each patient was clinically and endoscopically assessed...
  52. doi Effect of Da-Cheng-Qi decoction on the pharmacokinetics of ranitidine in rats
    Wen Fu Tang
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People s Republic of China
    Biomed Chromatogr 22:851-6. 2008
    ..The present study was conducted to evaluate the herb-drug interaction between DCQD and ranitidine, which are often co-administered in clinical practice...
  53. pmc A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers
    Monika Schöller-Gyüre
    Tibotec BVBA, Mechelen, Belgium
    Br J Clin Pharmacol 66:508-16. 2008
    ..This study evaluated the effect of steady-state omeprazole and ranitidine on the pharmacokinetics of a single dose of etravirine.
  54. ncbi Occurrence of ventilator-associated pneumonia in mechanically ventilated pediatric intensive care patients during stress ulcer prophylaxis with sucralfate, ranitidine, and omeprazole
    Dincer Yildizdas
    Department of Pediatrics, Division of Neonatology, Cukurova University, Adana, Turkey
    J Crit Care 17:240-5. 2002
    The purpose of the study was to evaluate the effects of sucralfate, ranitidine, and omeprazole use on incidence of ventilatory-associated pneumonia (VAP) and mortality in ventilated pediatric critical care patients.
  55. ncbi Effect of Helicobacter pylori eradication or of ranitidine plus metoclopramide on Helicobacter pylori-positive functional dyspepsia. A randomized, controlled follow-up study
    M Alizadeh-Naeeni
    Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Digestion 66:92-8. 2002
    ..A definitive treatment for functional dyspepsia (FD), and the role of Helicobacter pylori eradication on the course of this disease are controversial...
  56. ncbi The impact of primary antibiotic resistance on the efficacy of ranitidine bismuth citrate- vs. omeprazole-based one-week triple therapies in H. pylori eradication--a randomised controlled trial
    Josip Bago
    Department of Hepatogastroenterology, Internal Medicine, General Hospital Sveti Duh, Zagreb, Croatia
    Wien Klin Wochenschr 114:448-53. 2002
    To compare ranitidine bismuth citrate with omeprazole as to their efficacy to eradicate H...
  57. ncbi Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 317:635-43. 2006
    In an animal model of drug idiosyncrasy, rats cotreated with nonhepatotoxic doses of lipopolysaccharide (LPS) and ranitidine (RAN) develop hepatocellular injury, whereas rats treated with LPS and famotidine (FAM) do not...
  58. doi Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats
    Amal A El-Bakary
    Department of Forensic Medicine, Histology and Cytology, Faculty of Medicine, Mansoura University, Egypt
    Hum Exp Toxicol 29:93-101. 2010
    ..The therapy for methanol poisoning is alcohol dehydrogenase (ADH) inhibitors to prevent formate accumulation. Ranitidine has been considered to be an inhibitor of both gastric alcohol and hepatic aldehyde dehydrogenase enzymes...
  59. ncbi Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage
    Debashis Bandyopadhyay
    Indian Institute of Chemical Biology, Jadavpur, Kolkata, India, Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    J Pineal Res 33:1-7. 2002
    ..When compared with already marketed antiulcer drugs such as ranitidine and omeprazole, melatonin was found to be more effective than ranitidine but less effective than omeprazole in ..
  60. doi Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel
    David S Small
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Curr Med Res Opin 24:2251-7. 2008
    ..This study evaluated the influence of ranitidine coadministration on the pharmacokinetics and pharmacodynamics of the respective active metabolite of prasugrel ..
  61. pmc Pharmacokinetic interaction between darunavir boosted with ritonavir and omeprazole or ranitidine in human immunodeficiency virus-negative healthy volunteers
    Vanitha J Sekar
    Tibotec Inc, 1020 Stony Hill Road, Suite 300, Yardley, PA 19067, USA
    Antimicrob Agents Chemother 51:958-61. 2007
    ..This study was conducted to investigate the effect of ranitidine and omeprazole on the plasma pharmacokinetics of DRV and RTV in HIV-negative healthy volunteers...
  62. ncbi Using Terahertz pulse spectroscopy to study the crystalline structure of a drug: a case study of the polymorphs of ranitidine hydrochloride
    P F Taday
    TeraView Limited, 302 304 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK
    J Pharm Sci 92:831-8. 2003
    ..The particular compounds investigated were the different crystalline Forms 1 and 2 of ranitidine hydrochloride, both in the pure form and also obtained as a marketed pharmaceutical product...
  63. ncbi Seven-day is more effective than 4-day ranitidine bismuth citrate-based triple therapy in eradication of Helicobacter pylori in children: a prospective randomized study
    Y H Tam
    Division of Paediatric Surgery and Paediatric Urology, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Aliment Pharmacol Ther 24:81-6. 2006
    ..To date, there is still no universally accepted recommendation on the treatment of this infection in children. Ranitidine bismuth citrate-based triple therapy has been shown to be effective in H...
  64. ncbi Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy
    Tomasz Brzozowski
    Department of Physiology and Pathomorphology, Jagiellonian University School of Medicine, Cracow, Poland
    Scand J Gastroenterol 40:286-96. 2005
    ..inoculation on gastric secretion and healing of gastric ulcers induced by acetic acid in rats treated with 1) ranitidine (30 mg kg(-1) day(-1) s.c.) and 2) aspirin (ASA) (60 mg kg(-1) day(-1) i.g...
  65. ncbi A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation
    Magdalene Xenou Kokoletsi
    R and D Laboratory, Quality Control Department, DEMO SA Pharmaceutical Industry, 21st km National Road Athens Lamia, 14568 Athens, Greece
    J Pharm Biomed Anal 38:763-7. 2005
    ..liquid chromatographic method has been developed and validated for the simultaneous determination of ranitidine, methylparaben (MP) and propylparaben (PP) in oral liquids...
  66. pmc Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation
    Brijesh S Dave
    Shree S K Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, India
    AAPS PharmSciTech 5:e34. 2004
    The purpose of this research was to prepare a gastroretentive drug delivery system of ranitidine hydrochloride. Guar gum, xanthan gum, and hydroxypropyl methylcellulose were evaluated for gel-forming properties...
  67. ncbi Pregnancy outcome after exposure to ranitidine and other H2-blockers. A collaborative study of the European Network of Teratology Information Services
    Hanneke Garbis
    Teratology Information Service, National Institute of Public Health and Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 19:453-8. 2005
    ..Published data on pregnancy outcome after exposure to H2-blockers is scarce. The aim of the present study was to evaluate the data collected by the memberships of the European Network of Teratology Information Services (ENTIS)...
  68. ncbi Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses
    S A Apostolidis
    Laboratory of Anatomy, Aristotle University, Thessaloniki, Greece
    Tech Coloproctol 8:s104-7. 2004
    ..Wound healing is a process of immune system. This experimental study was done to find the effect of histamine2 receptor antagonist ranitidine on the healing process of intestinal anastomosis in rats.
  69. ncbi Drug costs developments after patent expiry of enalapril, fluoxetine and ranitidine: a study conducted for the Netherlands
    Cornelis Boersma
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University for Drug Exploration GUIDE, Groningen, The Netherlands
    Appl Health Econ Health Policy 4:191-6. 2005
    ..However, drug costs may not decrease after patent expiry, because of a lack of price competition and different national pricing systems...
  70. ncbi Healing of gastric ulcers with esomeprazole versus ranitidine in patients who continued to receive NSAID therapy: a randomized trial
    Jay L Goldstein
    University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Gastroenterol 100:2650-7. 2005
    To compare orally administered esomeprazole 40 mg once daily and 20 mg once daily with ranitidine 150 mg twice daily for the healing of gastric ulcers (GUs) during 8 wks in patients who continued to receive daily nonsteroidal anti-..
  71. ncbi Long-term management of patients with symptoms of gastro-oesophageal reflux disease -- a Norwegian randomised prospective study comparing the effects of esomeprazole and ranitidine treatment strategies on health-related quality of life in a general practi
    A N Hansen
    Harbitzallèen Legesenter, Oslo, Norway
    Int J Clin Pract 60:15-22. 2006
    ..were randomised to 6 months' esomeprazole 20 mg once daily continuously (n = 658), on-demand (n = 634) or ranitidine 150 mg twice daily continuously (n = 610)...
  72. ncbi Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 90:569-85. 2006
    Rats cotreated with lipopolysaccharide (LPS) and ranitidine (RAN) but not LPS and famotidine (FAM) develop hepatocellular injury in an animal model of idiosyncratic drug reactions...
  73. ncbi Efficacy and safety of pantoprazole versus ranitidine in the treatment of patients with symptomatic gastroesophageal reflux disease
    J van Zyl
    University Hospital, Bloemfontein, Germany
    Digestion 70:61-9. 2004
    ..epigastric pain, vomiting, nausea, flatulence, retching, and retrosternal feeling of tightness) and safety profiles of the proton pump inhibitor pantoprazole and the H2 antagonist ranitidine in patients suffering from symptomatic GERD.
  74. ncbi Oral ranitidine and duration of gastric pH >4.0 in infants with persisting reflux symptoms
    Silvia Salvatore
    Clinica Pediatrica di Varese, Universita dell Insubria, Varese, Italy
    Acta Paediatr 95:176-81. 2006
    b>Ranitidine is a drug commonly used in pathological gastro-oesophageal reflux (GOR) in infants. Non-responsiveness has been reported...
  75. ncbi Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes
    P W Dettmar
    Reckitt Benckiser Healthcare, Dansom Lane, Hull, UK
    Int J Clin Pract 60:275-83. 2006
    ..four-period crossover study was to compare the time of onset of effect of sodium alginate (SA), omeprazole, ranitidine and control, based on oesophageal and intragastric pH and to determine any correlation between reflux symptoms ..
  76. ncbi The effect of intravenous pantoprazole and ranitidine for improving preoperative gastric fluid properties in adults undergoing elective surgery
    Dilek Memis
    Departments of Anaesthesiology and Biostatistics, Trakya University Medical Faculty, Edirne, Turkey
    Anesth Analg 97:1360-3. 2003
    ..In this randomized, controlled trial, we examined the effects of preoperative IV pantoprazole or ranitidine on gastric pH and volume. Ninety patients (ASA status I and II, scheduled for elective surgery) were studied...
  77. ncbi Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    Dagmar Kubitza
    Institute of Clinical Pharmacology, Bayer HealthCare AG, Wuppertal, Germany
    J Clin Pharmacol 46:549-58. 2006
    To investigate the influence of food and administration of an antacid (aluminum-magnesium hydroxide) or ranitidine on the absorption of BAY 59-7939 (rivaroxaban), 4 randomized studies were performed in healthy male subjects...
  78. ncbi The impact of gastroesophageal reflux disease on quality of life
    T Kamolz
    Division of Clinical Psychology, Public Hospital of Zell am See, A 5700 Zell am See, Austria
    Surg Endosc 17:1193-9. 2003
    ..Quality of life as a medical endpoint has become an important measure in clinical research...
  79. ncbi Therapeutic efficacy of ranitidine bismuth citrate with clarithromycin for seven days in the eradication of Helicobacter pylori in Brazilian peptic ulcer patients
    Jaime Natan Eisig
    Departamento de Gastroenterologia Clínica, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Sao Paulo Med J 121:15-8. 2003
    ..The curative treatment of peptic ulcer is made available nowadays through the eradication of the bacterium Helicobacter pylori, which is associated with it, but the best therapeutic regimen is yet to be determined...
  80. ncbi Determination of polymorphic forms of ranitidine-HCl by DRIFTS and XRPD
    S Agatonovic-Kustrin
    School of Pharmaceutical Science, Universiti Sains Malaysia, 11800, Penang, Malaysia
    J Pharm Biomed Anal 25:741-50. 2001
    ..DRIFTS) and X-ray powder diffractometry (XRPD) were combined to analyze polymorphic purity of crystalline ranitidine-HCl, an antiulcer drug, H2 receptor antagonists...
  81. ncbi Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia
    B Kaplan-Machlis
    Department of Clinical Pharmacy, West Virginia University, Robert C Byrd Health Sciences Center, Charleston 25304, USA
    Arch Fam Med 9:624-30. 2000
    To compare clinical, health-related quality of life (HRQL), and medical cost outcomes in patients with symptomatic gastroesophageal reflux disease (GERD) receiving omeprazole sodium or ranitidine hydrochloride treatment.
  82. ncbi Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials
    J J Caro
    Division of General Internal Medicine, McGill University, Montreal, Quebec, Canada
    Clin Ther 23:998-1017. 2001
    ..The older proton pump inhibitor (PPI) omeprazole and the newer PPIs lansoprazole, rabeprazole, and pantoprazole are approved for the acute and maintenance treatment of gastroesophageal reflux disease (GERD)...
  83. ncbi Health-Related quality-of-life and quality-days incrementally gained in symptomatic nonerosive GERD patients treated with lansoprazole or ranitidine
    S D Mathias
    The Lewin Group, San Francisco, California 94107, USA
    Dig Dis Sci 46:2416-23. 2001
    ..GERD from two clinical trials of lansoprazole 15 mg daily (LAN 15) and lansoprazole 30 mg daily (LAN 30) vs ranitidine 150 mg twice a day (RAN 150) completed a health-related quality-of-life (HRQoL) questionnaire at baseline and ..
  84. ncbi Health-related quality of life outcomes of omeprazole versus ranitidine in poorly responsive symptomatic gastroesophageal reflux disease
    D A Revicki
    Center for Health Outcomes Research, MEDTAP International, Bethesda MD 20814, USA
    Dig Dis 16:284-91. 1998
    ..study evaluated changes in health-related quality of life (HRQL) outcomes of once-daily omeprazole compared with ranitidine for the short-term treatment of patients with poorly responsive symptomatic gastroesophageal reflux disease (..
  85. ncbi Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations
    E M Hassan
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P O Box 2457, 11451, Riyadh, Saudi Arabia
    J Pharm Biomed Anal 27:31-8. 2002
    A new simple and sensitive kinetic spectrophotometric method is described for analysis of nizatidine (I) and ranitidine (II)...
  86. ncbi Relapse prevention in reflux oesophagitis with regard to Helicobacter pylori status: a double-blind, randomized, multicentre trial to compare the efficacy of pantoprazole versus ranitidine
    R J Adamek
    Department of Medicine, St Vinzenz Krankenhaus, Duesseldorf, Germany
    Eur J Gastroenterol Hepatol 13:811-7. 2001
    OBJECTIVE: To compare prospectively the effectiveness of 1 year's treatment with pantoprazole versus ranitidine in order to prevent relapse after initial cure of reflux oesophagitis...
  87. ncbi Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury
    S Sartori
    Divisione di Medicina Interna e Oncologia Medica, Azienda Ospedaliera S Anna, Italy
    J Clin Oncol 18:463-7. 2000
    Anticancer drugs may induce acute mucosal injury to stomach and duodenum. This study was planned to evaluate the efficacy of omeprazole or ranitidine in preventing such an injury.
  88. ncbi Various durations of a standard regimen (amoxycillin, metronidazole, colloidal bismuth sub-citrate for 2 weeks or with additional ranitidine for 1 or 2 weeks) on eradication of Helicobacter pylori in Iranian peptic ulcer patients. A randomized controlled
    M J Kaviani
    Gastroenterology Division, Internal Medicine Ward, Shiraz University of Medical Sciences, Shiraz, Iran
    Eur J Gastroenterol Hepatol 13:915-9. 2001
    ..We therefore performed a randomized controlled trial comparing twice daily metronidazole, bismuth derivative and amoxycillin for 2 weeks with additional ranitidine for 1 or 2 weeks.
  89. ncbi Complete resolution of heartburn symptoms and health-related quality of life in patients with gastro-oesophageal reflux disease
    D A Revicki
    Center for Health Outcomes Research, MEDTAP International, Bethesda, MD 20814, USA
    Aliment Pharmacol Ther 13:1621-30. 1999
    ..We evaluated the association between complete resolution of heartburn symptoms and functioning and well-being in three samples of patients with GERD...
  90. ncbi Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy
    J P Gisbert
    Department of Gastroenterology, University Hospital of La Princesa, Madrid, Spain
    Aliment Pharmacol Ther 14:1141-50. 2000
    To compare the efficacy of proton pump inhibitor vs. ranitidine bismuth citrate (RBC) with two antibiotics for 1 week in Helicobacter pylori eradication.
  91. ncbi Solid state assay of ranitidine HCl as a bulk drug and as active ingredient in tablets using DRIFT spectroscopy with artificial neural networks
    S Agatonovic-Kustrin
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Pharm Res 16:1477-82. 1999
    A new, simple, sensitive and rapid method was developed to analyse the polymorphic purity of crystalline ranitidine-HCI as a bulk drug and from a tablet formulation.
  92. pmc Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomised controlled trials
    A Messori
    Laboratorio SIFO di Farmacoeconomia, Centro Informazione Farmaci, Servizio Farmaceutico, Azienda Ospedaliera Careggi, 50134 Florence, Italy
    BMJ 321:1103-6. 2000
    To determine the effectiveness of ranitidine and sucralfate in the prevention of stress ulcer in critical patients and to assess if these treatments affect the risk of nosocomial pneumonia.
  93. ncbi Control of nocturnal gastric acidity: a role for low dose bedtime ranitidine to supplement daily omeprazole
    Malcolm Robinson
    Oklahoma Foundation for Digestive Research, University of Oklahoma, Health Sciences Center, Oklahoma City, USA
    Dig Dis Sci 47:265-73. 2002
    ..measured at baseline and again after six days of 20 mg omeprazole alone at 08:00 hr followed by placebo, 75 mg ranitidine, or 20 mg omeprazole at 22:00 hr...
  94. ncbi [Eradication of Helicobacter pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2002]
    György Miklós Buzás
    Ferencvárosi Egészségügyi Szolgálat, Gasztroenterológia
    Orv Hetil 145:2035-41. 2004
    ..Meta-analyses evaluated several aspects of Helicobacter pylori eradication based on the randomised controlled trials...
  95. ncbi [The effect of Helicobacter pylori eradication on prokinetic treatment on the quality of life in functional dyspepsia]
    György Miklós Buzás
    Ferencvárosi Egészségügyi Szolgálat, Gasztroenterológia, Budapest
    Orv Hetil 145:2141-5. 2004
    ..The quality life is impaired in functional dyspepsia. Little is known, however, about the impact of different therapies on the quality of life in this condition...
  96. pmc Antibiotic resistance and antibiotic sensitivity based treatment in Helicobacter pylori infection: advantages and outcome
    M E Street
    Department of Paediatrics, University of Parma, Italy
    Arch Dis Child 84:419-22. 2001
    ..testing; those in group 2 received amoxycillin and clarithromycin for eight days, together with either ranitidine or omeprazole. Eradication rate was assessed in both groups six months after treatment...
  97. ncbi [A randomized, prospective, comparative, multicenter study of rabeprazole and ranitidine in the treatment of reflux esophagitis]
    Hyun Yong Jeong
    Department of Internal Medicine, Chungnam National University College of Medicine, Chungnam, Korea
    Korean J Gastroenterol 47:15-21. 2006
    This study was done to evaluate the efficacy of rabeprazole (proton-pump-inhibitor) and ranitidine (H(2)-receptor antagonist) in the symptom relief and treatment of erosive esophagitis diagnosed by endoscopy.
  98. ncbi 7-day rescue therapy with ranitidine bismuth citrate after Helicobacter pylori treatment failure
    J P Gisbert
    Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Madrid, Spain
    Aliment Pharmacol Ther 21:1249-53. 2005
    ..Quadruple rescue therapy requires a complex scheme with four drugs...
  99. ncbi First-line eradication therapy for Helicobacter pylori in primary health care based on antibiotic resistance: results of three eradication regimens
    T T Koivisto
    Department of Internal Medicine, South Karelia Central Hospital, 53130 Lappeenranta, Finland
    Aliment Pharmacol Ther 21:773-82. 2005
    ..To determine the efficacy of three Helicobacter pylori eradication regimens and factors affecting the eradication results in Finland...
  100. ncbi A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine
    A Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Drug Metabol Drug Interact 20:273-81. 2004
    The effect of ranitidine pretreatment on the pharmacokinetics of omeprazole was investigated in 14 male human volunteers...
  101. ncbi Heartburn-dominant, uninvestigated dyspepsia: a comparison of 'PPI-start' and 'H2-RA-start' management strategies in primary care--the CADET-HR Study
    D Armstrong
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 21:1189-202. 2005
    ..There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care...

Research Grants102 found, 100 shown here

  1. Regulation of Drug Metabolizing Enzyme Ontogeny
    Ronald N Hines; Fiscal Year: 2010
    ..Finally, ranitidine will be used as a probe drug to: a) determine the ontogenic profile of human FMO3 in vivo;b) determine whether ..
  2. Regulation of Drug Metabolizing Enzyme Ontogeny
    RONALD HINES; Fiscal Year: 2009
    ..Finally, ranitidine will be used as a probe drug to: a) determine the ontogenic profile of human FMO3 in vivo; b) determine whether ..
  3. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  4. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2010
    ..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
  5. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2009
    ..A better understanding of effects of acid inhibition on H. pylori may allow improvement or replacement of triple therapy for eradication. ..
  6. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
  7. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2009
    ..A future direction for this research group will be to devise and test a "corrective intervention" based on those physiological objectives. ..
  8. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2004
    ....
  9. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2010
    ..A better understanding of effects of acid inhibition on H. pylori may allow improvement or replacement of triple therapy for eradication. ..
  10. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2010
    ..This proposal will uncover new biochemical mechanisms for pain relief, and test a new group of chemicals for pain-relieving properties. This research could lead to the development of new, non-addicting pain relievers. ..
  11. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
  12. INFLAMMATION AND DRUG IDIOSYNCRASY
    ROBERT ANDREW ROTH; Fiscal Year: 2010
    ....
  13. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2007
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  14. GASTRIC BIOLOGY OF HELICOBACTER PYLORI
    George Sachs; Fiscal Year: 2007
    ..pylori has evolved to colonize the human stomach. These studies may provide targets to allow eradication of this class 1 carcinogen without the use of general antibiotics. ..
  15. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2007
    ..These collaborative experiments between pharmacologists, neurophysiologists and chemists will discover the mechanism of action of this novel class of agents and lead to the development of new, non-opioid pharmacotherapies for pain. ..
  16. NEUTROPHILS AND HEPATOTOXICITY
    Robert Roth; Fiscal Year: 2009
    The capacity of modest inflammation to potentiate hepatotoxic responses to drugs (e.g., ranitidine) and other xenobiotic agents has been characterized in several animal models...
  17. GASTRIC ENTEROCHROMAFFIN LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 1999
    ..These data will allow a novel understanding of the peripheral regulation of gastric acid secretion as well as the exocytotic process in a non- excitable endocrine cell. ..
  18. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2003
    ....
  19. NEUTROPHILS AND HEPATOTOXICITY
    Robert Roth; Fiscal Year: 1990
    ..The long-term goal of this research is to determine the extent and nature of the participation of stimulated phagocytic cells in toxic responses to chemicals...
  20. SAMe Inhibits Inflammatory-mediated Enhanced Toxicity
    JANE MADDOX; Fiscal Year: 2003
    ..Moreover, they may provide evidence for development of related therapeutic compounds. ..
  21. GASTRIC BIOLOGY OF HELICOBACTER PYLORI
    George Sachs; Fiscal Year: 2002
    ..Understanding the means of survival and cytotoxicity of this pathogen will enable more rational treatment of peptic ulcer disease. ..
  22. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1992
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...
  23. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 1999
    ..These studies will clarify the mechanisms by which MOR relieves pain, enhance the understanding of histaminergic antinociceptive mechanisms, and may lead to the discovery of non-addicting, novel medications for the treatment of pain. ..
  24. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2009
    ....
  25. Impact of Medicaid Policy on cardiovascular drug use and clinical outcomes
    Michael A Fischer; Fiscal Year: 2010
    ....
  26. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  27. INFLAMMATION AND DRUG IDIOSYNCRASY
    Robert Roth; Fiscal Year: 2006
    ..Similarly, a nontoxic dose of LPS; can render ranitidine hepatotoxic in rats and mice...
  28. PSYCHOPHYSICAL INVESTIGATION OF UMAMI TASTE
    Russell Keast; Fiscal Year: 2004
    ..abstract_text> ..
  29. NEUTROPHILS AND HEPATOTOXICITY
    Robert Roth; Fiscal Year: 2002
    ..The results will provide new knowledge about how LPS and the inflammatory events it generates may act as a determinant of the magnitude of response to toxicants. ..