dioxanes

Summary

Summary: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)

Top Publications

  1. ncbi Evaluation of novel biodegradable cyclic carbonate polyester copolymers for cytocompatibility using MRC-5 cells
    J Longino
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 39:306-11. 2003
  2. ncbi [Comparison of five synthetic absorbable suture materials in intestinal anastomosis: experimental study in rats]
    Carlo De Werra
    Cattedra di Chirurgia Generale, Universita degli Studi di Napoli Federico II, Napoli
    Chir Ital 55:227-33. 2003
  3. doi Patient age and vasospasm after subarachnoid hemorrhage
    Mats Ryttlefors
    Department of Neuroscience, Section for Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 67:911-7. 2010
  4. doi Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
  5. doi Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats
    Gerrit A Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 109:1134-40. 2008
  6. ncbi Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists
    Laura C McAtee
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:4225-9. 2004
  7. pmc Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, The Purdue Cancer Center, West Lafayette, IN 47907, USA
    Bioorg Med Chem 15:2667-79. 2007
  8. ncbi Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, The Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA
    Bioorg Med Chem Lett 15:3207-11. 2005
  9. pmc Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
    Jason R Harris
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Lett 11:3290-3. 2009
  10. ncbi Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series
    M Barth
    Department of Neurosurgery, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Acta Neurochir (Wien) 149:911-8; discussion 918. 2007

Detail Information

Publications180 found, 100 shown here

  1. ncbi Evaluation of novel biodegradable cyclic carbonate polyester copolymers for cytocompatibility using MRC-5 cells
    J Longino
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 39:306-11. 2003
    ..Although both copolymers are non-cytotoxic, the sample having the higher MBC content is the preferred composition based upon MDA levels and morphological evaluations...
  2. ncbi [Comparison of five synthetic absorbable suture materials in intestinal anastomosis: experimental study in rats]
    Carlo De Werra
    Cattedra di Chirurgia Generale, Universita degli Studi di Napoli Federico II, Napoli
    Chir Ital 55:227-33. 2003
    ..A general assessment showed better results for polyglycolic acid and Glycomer 631, while the other three materials presented slightly inferior performance, particularly polygalactic acid (inferior stitch resistance)...
  3. doi Patient age and vasospasm after subarachnoid hemorrhage
    Mats Ryttlefors
    Department of Neuroscience, Section for Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 67:911-7. 2010
    ..Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating disease with high mortality and morbidity. The incidence of SAH increases with advancing age...
  4. doi Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
    ....
  5. doi Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats
    Gerrit A Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 109:1134-40. 2008
    ..The purpose of this study was to further determine the role of ET in the first minutes to hours after massive experimental SAH induced by prophylactic treatment with the ET receptor antagonist clazosentan...
  6. ncbi Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists
    Laura C McAtee
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:4225-9. 2004
    ..Herein we describe a series of novel, selective OX(2)R antagonists consisting of substituted 4-phenyl-[1,3]dioxanes. One such antagonist is compound 9, 1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-..
  7. pmc Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, The Purdue Cancer Center, West Lafayette, IN 47907, USA
    Bioorg Med Chem 15:2667-79. 2007
    ..4 microM as an inhibitor of Sindbis virus replication. Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1mM...
  8. ncbi Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, The Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA
    Bioorg Med Chem Lett 15:3207-11. 2005
    ..Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1mM...
  9. pmc Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
    Jason R Harris
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Lett 11:3290-3. 2009
    ..of gamma,delta-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products...
  10. ncbi Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series
    M Barth
    Department of Neurosurgery, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Acta Neurochir (Wien) 149:911-8; discussion 918. 2007
    ..To study the effects of clazosentan, a new selective endothelin receptor subtype A antagonist, on cerebral perfusion and cerebral oxygenation following severe aneurysmal subarachnoid haemorrhage (aSAH)...
  11. doi Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
    J Neurosurg 115:1191-6. 2011
    ..Numerous abnormal findings may be evident on CT scans after aneurysmal subarachnoid hemorrhage (SAH). Here, the authors assess the interobserver variability in the radiological interpretation of the initial CT scan following SAH...
  12. doi Three-year follow-up of modified Lichtenstein inguinal hernioplasty using lightweight poliglecaprone/polypropylene mesh
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, ul Debinki 7, 80 211, Gdansk, Poland
    Hernia 13:239-42. 2009
    ....
  13. ncbi Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes
    Jason C Wong
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Biol 11:1279-91. 2004
    Modular synthesis and substrate stereocontrol were combined to furnish 18,000 diverse 1,3-dioxanes whose distribution in chemical space rivals that of a reference set of over 2,000 bioactive small molecules...
  14. doi Randomized clinical trial comparing a polypropylene with a poliglecaprone and polypropylene composite mesh for inguinal hernioplasty
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, 7 Debinki Street, 80 211 Gdansk, Poland
    Br J Surg 95:1462-8. 2008
    ..The aim was to assess whether a partially absorbable monofilament mesh could influence postoperative pain and time to return to normal activity after Lichtenstein hernioplasty...
  15. ncbi In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or epsilon-caprolactone: Degradation and tissue response
    A P Pêgo
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Chemical Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Biomed Mater Res A 67:1044-54. 2003
    ....
  16. ncbi Tolerability, pharmacokinetics, and pharmacodynamics of clazosentan, a parenteral endothelin receptor antagonist
    Paul L M van Giersbergen
    Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 18, 4123 Allschwil, Switzerland
    Eur J Clin Pharmacol 63:151-8. 2007
    ..The purpose of this study was to investigate in healthy male subjects the tolerability, pharmacokinetics, and pharmacodynamics of ascending doses of clazosentan, an intravenous endothelin receptor antagonist...
  17. ncbi Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays
    S M Sternson
    Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Chem Soc 123:1740-7. 2001
    ..We have developed a split--pool synthesis leading to an array of stock solutions of single 1,3-dioxanes. The quantities of compounds are sufficient for hundreds of phenotypic and protein-binding assays...
  18. ncbi Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
    ..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...
  19. ncbi The in vivo and in vitro degradation behavior of poly(trimethylene carbonate)
    Zheng Zhang
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:1741-8. 2006
    ..It can be concluded that enzymatic degradation plays an important role in the surface erosion of PTMC in vivo...
  20. ncbi Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents
    Caterina Fattorusso
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Med Chem 49:7088-94. 2006
    ..a series of semisynthetic derivatives in order to gain insights into the structural requirements of simple 1,2-dioxanes for exhibiting antimalarial activity...
  21. ncbi Enzymatic surface erosion of poly(trimethylene carbonate) films studied by atomic force microscopy
    Zheng Zhang
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands
    Biomacromolecules 6:3404-9. 2005
    ..Friction images showed differences in surface properties between the recessed and protruding lines in the pattern...
  22. ncbi [Biological properties study and animal experiment of polylactide/polytrimethylene carbonate blends membrane]
    Xiaoqiang Yang
    Research Institute of Daily Chemistry of China, Taiyuan 030024, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:578-82. 2006
    ..In the experimental application of this member to preventing adhesion after rabbit intestine operation, the membrane demonstrated good effect. In conclusion, PLA/PTMC blends membrane is a material with good biocompatibility...
  23. ncbi Creep-resistant porous structures based on stereo-complex forming triblock copolymers of 1,3-trimethylene carbonate and lactides
    Zheng Zhang
    Institute for Biomedical Technology BMTI, Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The Netherlands
    J Mater Sci Mater Med 15:381-5. 2004
    ..After prolonged compressive deformation, solid and porous poly(ST-TMC-ST) discs showed significantly better recovery behaviour than poly(TMC) discs...
  24. ncbi The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tissue
    Dorothee Rickert
    Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Prittwitzstr 43, 89075 Ulm, Germany
    Clin Hemorheol Microcirc 28:175-81. 2003
    ....
  25. ncbi Evaluation of the tensile strengths of four monofilament absorbable suture materials after immersion in canine urine with or without bacteria
    Chelsea B Greenberg
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 65:847-53. 2004
    ..To evaluate the tensile strength, elongation, and degradation of 4 monofilament absorbable suture materials that undergo degradation by hydrolysis in specimens of canine urine with various physical characteristics...
  26. ncbi Loading and release of ibuprofen in multi- and monofilament surgical sutures
    Raül Zurita
    Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, Av Diagonal 647, E 08028, Barcelona, Spain
    Macromol Biosci 6:767-75. 2006
    ..This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred...
  27. ncbi Polylactones 57. Biodegradable networks based on A-B-A triblock segments containing poly(ethylene glycol)s-syntheses and drug release properties
    Hans R Kricheldorf
    Institut fur Technische und Makromolekulare Chemie, Bundesstr 45, D 20146 Hamburg, Germany
    Biomacromolecules 4:950-5. 2003
    ..A strong initial burst was found in all cases. Only a weak initial burst and a more continuous release was observed when networks of random L-lactide/epsilon-caprolactone copolymers were studied under the same conditions...
  28. ncbi Resorbable plates for the fixation of mandibular fractures: a prospective study
    Robert M Laughlin
    Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA, USA
    J Oral Maxillofac Surg 65:89-96. 2007
    ....
  29. ncbi Enhanced extracellular matrix production and differentiation of human embryonic germ cell derivatives in biodegradable poly(epsilon-caprolactone-co-ethyl ethylene phosphate) scaffold
    Evelyn K F Yim
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Acta Biomater 2:365-76. 2006
    ..The study showed that the polymer substrate could influence the differentiation and growth of pluripotent stem cells in the absence of exogenous biochemical signals...
  30. ncbi CAPROSYN*, another major advance in synthetic monofilament absorbable suture
    Angela Pineros-Fernandez
    University of Virginia Health System, Charlottesville, Virginia 22908 1351, USA
    J Long Term Eff Med Implants 14:359-68. 2004
    ....
  31. ncbi Surface functionalization of degradable polymers by covalent grafting
    Martina Källrot
    School of Chemical Science and Engineering, Royal Institute of Technology, Fibre and Polymer Technology, SE 100 44 Stockholm, Sweden
    Biomaterials 27:1788-96. 2006
    ....
  32. ncbi Mechanical strength and stiffness of biodegradable and titanium osteofixation systems
    Gerrit J Buijs
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Oral Maxillofac Surg 65:2148-58. 2007
    ..To present relevant mechanical data to simplify the selection of an osteofixation system for situations requiring immobilization in oral and maxillofacial surgery...
  33. ncbi Thermoplastic elastomers based on poly(lactide)-poly(trimethylene carbonate-co-caprolactone)-poly(lactide) triblock copolymers and their stereocomplexes
    Z Zhang
    Institute for Biomedical Technology, Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands
    J Control Release 116:e29-31. 2006
  34. ncbi Bacterial colonization on different suture materials--a potential risk for intraoral dentoalveolar surgery
    J E Otten
    Klinik und Poliklinik fur Mund, Kiefer und Gesichtschirurgie, Albert Ludwigs Universitat Freiburg, Germany
    J Biomed Mater Res B Appl Biomater 74:627-35. 2005
    ..Coccoid bacteria within biofilms were seen. The growth of Prevotella intermedia was much better on Deknalon than on Monocryl. The risk of bacteremia at the time of suture removal is discussed...
  35. ncbi Different substitute biomaterials as potential scaffolds in tissue engineering
    Ljubinko Petrovic
    Oral and Maxillofacial Surgery Department, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Int J Oral Maxillofac Implants 21:225-31. 2006
    ..In this study, the suitability of different alloplastic and xenogenic biomaterials as scaffolds for ex vivo osteoblast cultivation was investigated...
  36. doi Biodegradable polycarbonate-b-polypeptide and polyester-b-polypeptide block copolymers: synthesis and nanoparticle formation towards biomaterials
    Maude Le Hellaye
    Laboratoire de Chimie des Polymeres Organiques, LCPO, Université Bordeaux 1 CNRS ENSCPB, 16 Avenue Pey Berland, 33607 Pessac Cedex, France
    Biomacromolecules 9:1924-33. 2008
    ..Finally, their enzymatic degradation revealed that PTMC nanoparticles degraded faster than those made of PCL...
  37. ncbi Preparation of biodegradable networks by photo-crosslinking lactide, epsilon-caprolactone and trimethylene carbonate-based oligomers functionalized with fumaric acid monoethyl ester
    Dirk W Grijpma
    Faculty of Science and Technology, Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 26:2795-802. 2005
    ..Such networks, built up of non-toxic compounds and designed to release benign degradation products, may find wide application in tissue engineering and other areas of biomedical research...
  38. ncbi Biodegradable self-assembling PEG-copolymer as vehicle for poorly water-soluble drugs
    Louisa Ould-Ouali
    Universite Catholique de Louvain, Department of Pharmaceutical Technology, Brussels, Belgium
    Pharm Res 21:1581-90. 2004
    ..To develop self-assembling systems increasing the solubility of poorly water-soluble drugs...
  39. ncbi [Clinical and histopathological study of tissue reactivity to monofilament suture materials: nylon and poliglecaprone 25 in rats]
    Camila Maria Beder Ribeiro
    Universidade Federal de Pernambuco, Recife, PE, Brazil
    Acta Cir Bras 20:284-91. 2005
    ..The aim of this experimental study was to evaluate through a clinical and histopathological analysis the tissue reactivity caused by two monofilament sutures nylon and poliglecaprone 25 on the internal and external sutures in rats...
  40. ncbi Comparative study of tissue response to polyglecaprone 25, polyglactin 910 and polytetrafluorethylene suture materials in rats
    Hugo Nary Filho
    Department of Oral Surgery, School of Dentistry, Sacred Heart University USC, Bauru, SP, Brazil
    Braz Dent J 13:86-91. 2002
    ..Such biological behavior must be considered during the selection of the suture material to be used in oral surgery...
  41. ncbi Macroporous poly(L-lactide) scaffold 1. Preparation of a macroporous scaffold by liquid--liquid phase separation of a PLLA--dioxane--water system
    Feng Jun Hua
    Center for Advanced Functional Polymers, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Kyungki 440 746, Korea
    J Biomed Mater Res 63:161-7. 2002
    ..This gelation effect was greater at high polymer concentrations and low quenching temperatures. The macroporous expected scaffold could be optimized from the slow development of phase separation during the long coarsening process...
  42. ncbi Biodegradable, elastic shape-memory polymers for potential biomedical applications
    Andreas Lendlein
    mnemoScience GmbH, Pauwelsstrabetae 19, D 52074 Aachen, Germany
    Science 296:1673-6. 2002
    ..A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications...
  43. ncbi 1H and 13C NMR studies of molecular dynamics in the biocopolymer of glycolide and epsilon-caprolactone
    Farhod Nozirov
    Department of Macromolecular Physics, Adam Mickiewicz University, Poznan, Poland
    Solid State Nucl Magn Reson 22:19-28. 2002
    ..T, relaxation is dominated by trans-gauche isomerisation, with an activation energy of 34-35 kJ mol(-1)...
  44. ncbi Fabrication of porous particulate for the scaffold by applying solution spraying method
    Hideki Tamasaki
    Division of Dental Anesthesiology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Dent Mater J 24:76-82. 2005
    ..Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions...
  45. ncbi Copolymerizations of epsilon-caprolactone and glycolide-a comparison of tin(II)octanoate and bismuth(III)subsalicylate as initiators
    Hans R Kricheldorf
    Institut fur Technische und Makromolekulare Chemie, Bundesstr 45, D 20146 Hamburg, Germany
    Biomacromolecules 6:1345-52. 2005
    ..Time-conversion curves and MALDI-TOF mass spectrometry of homopolymerization suggest that SnOct(2) is the more efficient transesterification catalyst. A hypothetical reaction mechanism is discussed...
  46. ncbi Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan
    Wayne E Childers
    Chemical and Screening Sciences and Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 48:3467-70. 2005
    ..Compound 11c (Lecozotan) was selected for further development and is currently in clinical trials...
  47. ncbi Lightweight partially absorbable monofilament mesh (polypropylene/poliglecaprone 25) for TAPP inguinal hernia repair: initial experience
    Ferdinando Agresta
    Department of General Surgery, Ospedale Civile, Via Forlanini, 71, 31029 Vittorio Veneto, Italy
    Surg Laparosc Endosc Percutan Tech 17:91-4. 2007
    ....
  48. ncbi Fibroblast culture on surface-modified poly(glycolide-co-epsilon-caprolactone) scaffold for soft tissue regeneration
    I K Kwon
    Biomaterials Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul
    J Biomater Sci Polym Ed 12:1147-60. 2001
    ..These results demonstrate that surface-modified PGCL scaffold can provide a suitable substrate for fibroblast culture, especially in the case of soft tissue regenerations...
  49. ncbi Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). I. Preparation and visible light-induced photocuring characteristics
    Manabu Mizutani
    Department of Bioengineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Biomed Mater Res 62:387-94. 2002
    ..Cylindrical photocured constructs prepared by photoirradiation to the whole body in a mold filled with the liquid copolymer was demonstrated as an example of shape fabrication of biodegradable biomedical devices...
  50. ncbi Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). II. Computer-aided stereolithographic microarchitectural surface photoconstructs
    Takehisa Matsuda
    Department of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biomed Mater Res 62:395-403. 2002
    ..Anti-inflammatory drug (indomethacin) loading into microneedle-structured surfaces minimized inflammatory reactions. The possible biomedical microarchitectural three dimensinal in biomedical application photoconstructs was discussed...
  51. ncbi Multiblock copolymers of L-lactide and trimethylene carbonate
    Doris Pospiech
    Institut fur Technische und Makromolekulare Chemie, Bundesstrasse 45, D 20146 Hamburg, Germany
    Biomacromolecules 6:439-46. 2005
    ..Stress-strain measurements showed the elastomeric character of these biodegradable multiblock copolymers, particularly in copolymers having epsilon-caprolactone as comonomer in the poly(TMC) blocks...
  52. ncbi Safety and efficacy of the use of bioabsorbable seamguard in colorectal surgery at the Texas endosurgery institute
    Morris E Franklin
    Texas Endosurgery Institute, San Antonio, TX 78222, USA
    Surg Laparosc Endosc Percutan Tech 15:9-13. 2005
    ..The use of BSG as a staple-line reinforcer appears to be safe and may be useful in preventing anastomotic leakage, bleeding, and intraluminal stenosis...
  53. ncbi In vivo antibacterial efficacy of MONOCRYL plus antibacterial suture (Poliglecaprone 25 with triclosan)
    Xintian Ming
    Corporate Microbiology and Sterilization Sciences, Ethicon Inc, Somerville, NJ 08876, USA
    Surg Infect (Larchmt) 8:209-14. 2007
    ..This study evaluated the ability of poliglecaprone 25 suture with triclosan to inhibit bacterial colonization by Escherichia coli and Staphylococcus aureus in mouse and guinea pig models...
  54. ncbi Comparison of inflammatory response to polyglytone 6211 and polyglecaprone 25 in a rat model
    Johan van Heerden
    Department of Plastic Surgery, Ga Rankuwa Hospital, Pretoria, South Africa
    S Afr Med J 95:972-4. 2005
  55. ncbi Subcuticular closure versus Dermabond: a prospective randomized trial
    Erin F Switzer
    Department of Surgery, Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
    Am Surg 69:434-6. 2003
    ..Based on these findings we do not feel Dermabond is an acceptable alternative to subcuticular suture closure in inguinal herniorrhaphy incisions...
  56. ncbi Octyl-2-cyanoacrylate tissue glue (Dermabond) versus Monocryl 6 x 0 Sutures in lip closure
    Paul H M Spauwen
    Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    Cleft Palate Craniofac J 43:625-7. 2006
    ..To assess the value of octyl-2-cyanoacrylate tissue glue in lip closure versus Monocryl stitches...
  57. ncbi Tying a loop-to-strand suture: is it safe?
    Jason Hurt
    Division of Gynecologic Pelvic Surgery, Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Obstet Gynecol 192:1094-7. 2005
    ..This study was undertaken to evaluate the integrity of the loop-to-strand knot when tied with square and nonidentical sliding knots...
  58. ncbi [Tracheal anastomosis: monofilament absorbable suture versus monofilament non-absorbable suture. Experimental study in rats]
    D S Lazard
    Service ORL et Chirurgie Cervico Faciale, Hopital Foch, 40 rue Worth, 92151 Suresnes
    Ann Otolaryngol Chir Cervicofac 121:156-60. 2004
    ..A multifilament absorbable suture is usually used. The aim of this experimental work on rats was to study the benefits of using a monofilament absorbable suture with high initial resistance...
  59. ncbi Laparoscopic suturing: effect of instrument handling on suture strength
    Simon V Bariol
    Scottish Lithotriptor Centre, Western General Hospital, Edinburgh, UK
    J Endourol 19:1127-33. 2005
    ..Also, the ideal suturing technique (interrupted v continuous) according to the physical characteristics of the suture material and the optimal length for laparoscopic sutures were determined...
  60. ncbi Investigation of the role of the serotonergic activity of certain subtype-selective alpha1A antagonists in the relaxant effect on the pregnant rat uterus in vitro
    Attila Mihalyi
    University of Szeged, Faculty of Pharmacy, Department of Pharmacodynamics and Biopharmacy, H 6720 Szeged, Eotvos u 6, Hungary
    Mol Hum Reprod 9:475-80. 2003
    ..It is proposed that novel alpha(1A) antagonists should be designed with no 5-HT(1A) activity to achieve maximal relaxant effect...
  61. ncbi Series spiral advancement flap: an alternative to the ellipse
    P J Weber
    Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA
    Dermatol Surg 27:64-6. 2001
    ..Proper patient and lesion selection aids in obtaining an acceptable outcome. CONCLUSION: The series spiral advancement flap has the potential to become a useful and common surgical technique...
  62. ncbi Strength and knot security of braided polyester and caprolactone/glycolide suture
    Christopher Bibbo
    Department of Orthopaedic Surgery, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
    Foot Ankle Int 25:712-5. 2004
    ..This study compared the security of the knots and ultimate tensile strength of braided caprolactone/glycolide suture to that of a commonly used suture material, braided polyester (Ethibondtrade mark)...
  63. ncbi Control of pore size in L-lactide/epsilon-caprolactone copolymer foams for tissue regeneration by the freeze-drying method
    Hiroyuki Nakao
    Division of Biomaterials Science, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dent Mater J 22:262-71. 2003
    ..This suggests that the higher cooling rate due to lower cooling temperature can produce smaller ice-crystals and result in smaller pores...
  64. ncbi Bioreabsorbable polymer scaffold as temporary meniscal prosthesis
    Ana Paula Testa Pezzin
    State University of Campinas, UNICAMP, Faculty of Mechanical Engineering, Campinas, SP, Brazil
    Artif Organs 27:428-31. 2003
    ....
  65. ncbi Triclosan release from coated polyglycolide threads
    Raül Zurita
    Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, 08028 Barcelona, Spain
    Macromol Biosci 6:58-69. 2006
    ..Partition and diffusion coefficients are also estimated...
  66. ncbi Photo-polymerized microarchitectural constructs prepared by microstereolithography (muSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers
    Il Keun Kwon
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biomaterials 26:1675-84. 2005
    ..In this paper, we discuss their potential biomedical applications...
  67. ncbi A review of taste and odour events in Barcelona's drinking water area (1990-2004)
    M R Boleda
    AGBAR, Aigues de Barcelona Avinguda Diagonal, 211, 08018 Barcelona, Spain
    Water Sci Technol 55:217-21. 2007
    ..Events produced by creosote, dioxanes and dioxolanes, dicylopentadiene, and diacetyl, among the anthropogenic compounds; geosmin, MIB and iodinated ..
  68. ncbi New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible?
    Seymour Lieberman
    Department of Obstetrics and Gynecology, Institute for Health Sciences, St Luke s Roosevelt Hospital Center, 432 West 58th Street, New York, NY 10019, USA
    J Steroid Biochem Mol Biol 94:405-20. 2005
    ..by a computer program, suggest that the oxidized intermediates resemble hydroperoxides or cyclic peroxides (1,2-dioxanes)...
  69. doi Dihydroxylation of 4-substituted 1,2-dioxines: a concise route to branched erythro sugars
    Tony V Robinson
    Department of Chemistry, The University of Adelaide, South Australia 5005, Australia
    J Org Chem 74:5093-6. 2009
    ..The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to optically enriched dihydroxy 1,2-dioxanes 4...
  70. doi A novel method for the determination of total 1,3-octanediols in apple juice via 1,3-dioxanes by solid-phase microextraction and high-speed gas chromatography
    Daniel Díaz Llorente
    Departamento de Quimica Fisica y Analitica, Universidad de Oviedo, c Julian Claveria 8, E 33006 Oviedo, Spain
    J Chromatogr A 1217:2993-9. 2010
    ..for the analysis of total 1,3-octanediols in apple juices by means of derivatization reaction to volatile 1,3-dioxanes. The derivatization reaction, SPME conditions, glycosidically bound fraction and 1,3-nonanediol as a surrogate ..
  71. ncbi Stereoselective hydroformylation: key step for the assembly of polypropionate subunits
    B Breit
    Organisch Chemisches Institut, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
    J Org Chem 66:4870-7. 2001
    An anti-selective hydroformylation of 2-propylidene-substituted 1,3-dioxanes 16, 17, and 26 with excellent levels of acyclic stereocontrol has been achieved...
  72. ncbi Synthetic peroxides as potent antimalarials. News and views
    Charles W Jefford
    Department of Organic Chemistry, University of Geneva, 1211 Geneva 4, Switzerland
    Curr Top Med Chem 12:373-99. 2012
    ..Thereafter, news about 1,2,4-trioxolanes, 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, 1,2-dioxolanes, and 1,2-dioxanes is recounted, emphasizing aspects of design, mechanism, and the importance of the adamantane entity for ..
  73. ncbi Endothelin receptor antagonists for aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update
    Mervyn D I Vergouwen
    UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Stroke 43:2671-6. 2012
    ..We present the results of a systematic review and meta-analysis update...
  74. doi Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone
    L Hausermann
    Centre de Recherche, CHU Sainte Justine, 3175, Chemin de la Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Placenta 32:941-8. 2011
    ..The presence of these receptors and the actions exerted by their agonists support our postulate that prostanoids play an important regulatory role in placental vascular tone and resistance. NO, however, does not seem to be involved...
  75. doi Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism
    Milos Ilić
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia
    Eur J Med Chem 62:329-40. 2013
    ..67 ± 0.27 μM and IC50(GPIIb/IIIa) = 0.665 ± 0.26 μM, raising the hope that merging anticoagulant and platelet antiaggregatory activities in the same molecule could lead to successful multitarget antithrombotic agents...
  76. doi Positron scattering from the cyclic ethers oxirane, 1,4-dioxane, and tetrahydropyran
    A Zecca
    Department of Physics, University of Trento, Povo, I 38123 Trento, Italy
    J Chem Phys 136:124305. 2012
    ..However, electron TCSs for oxirane (also known as ethylene oxide) and tetrahydropyran do currently exist in the literature and a comparison to them for each species will be presented...
  77. doi Cryptands with 1,3,5-tris(1',3'-dioxan-2'-yl)-benzene units: synthesis and structural investigations
    Monica Cîrcu
    Center of Supramolecular Organic and Organometallic Chemistry, Cluj Napoca, Babes Bolyai University, 11 Arany Janos Str, 400028, Cluj Napoca, Romania
    J Org Chem 78:8722-9. 2013
    ..The role of the 1,3-dioxane units was targeted to ensure the preorganization of the substrate for the macrocyclization reactions on one side, and for easier NMR assignment of the structure of the cryptands on the other side. ..
  78. ncbi Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats
    Carlos Alberto Lima Utrabo
    School of Medicine, State University of Ponta Grossa, PR, Brazil
    Acta Cir Bras 27:300-5. 2012
    ..To evaluate the healing process of a defect in the ventral abdominal wall of rats, comparing the polypropylene and polypropylene/poliglecaprone meshes on the 30(th) and 60(th) postoperative day...
  79. ncbi An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine
    Haruhiko Fuwa
    Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    Org Biomol Chem 5:1849-53. 2007
    ..This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine...
  80. ncbi Torsion strength of biodegradable and titanium screws: a comparison
    Gerrit J Buijs
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Oral Maxillofac Surg 65:2142-7. 2007
    ....
  81. ncbi Polymeric scaffolds prepared via thermally induced phase separation: tuning of structure and morphology
    F Carfì Pavia
    Dipartimento di Ingegneria Chimica dei Processi e dei Materiali, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    J Biomed Mater Res A 86:459-66. 2008
    ..30% in 30 days) related to the degradation of the amorphous part, followed by a negligible weight loss in the next days (few percent from 30 to 60 days)...
  82. doi Enantioselective synthesis of homo-N-nucleosides containing a 1,4-dioxane sugar analog
    Qiang Yu
    Department of Chemistry, Norwegian University of Science and Technology NTNU, N 7491 Trondheim, Norway
    Molecules 13:2962-74. 2008
    ....
  83. doi Enhancement of reference memory in aged rats by specific activation of 5-HT(4) receptors using an olfactory associative discrimination task
    Evelyne Marchetti
    Lab Neurobiologie des Processus Mnésiques UMR 6149 CNRS, Université de Provence Centre St Charles 3, place Victor Hugo 13331 Marseille Cedex 03, France
    Brain Res 1405:49-56. 2011
    ..This agent could be used to treat early mnesic deficits observed in normal aging or in neurodegenerative disorders like Alzheimer disease...
  84. doi Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists
    Tina Utech
    Institut fur Pharmazeutische und Medizinische Chemie, Westfälischen Wilhelms Universität Münster, Hittorfstraße 58 62, D 48149 Munster, Germany
    Eur J Med Chem 46:2157-69. 2011
    ..The synthesis of aminoethyl-1,3-dioxanes 13, 22, 23 and 29 was performed by transacetalization of various acetals with pentane-1,3,5-triol, activation of ..
  85. doi Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists
    Tomiyoshi Aoki
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Bioorg Med Chem Lett 18:2128-32. 2008
    ..This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-A(y) mice...
  86. doi Design and characterization of a biodegradable composite scaffold for ligament tissue engineering
    James W S Hayami
    Department of Chemical Engineering, Queen s University, Kingston, Canada
    J Biomed Mater Res A 92:1407-20. 2010
    ..On the basis of these results, it was determined that the composite scaffold design was a viable alternative to the current approaches used for ligament tissue engineering and merits further study...
  87. doi Risk of gastrojejunal anastomotic stricture with multifilament and monofilament sutures after hand-sewn laparoscopic gastric bypass: a prospective cohort study
    Juan Carlos Ruiz de Adana
    Cirugia General y Digestivo, Hospital Universitario de Getafe, Crta Toledo Km 12 5, 28905 Getafe, Madrid, Spain
    Obes Surg 19:1274-7. 2009
    ..The object of this study was to assess the risk of stricture for two types of resorbable suture (multifilament and monofilament) in a series of LRYGBPs performed by the same surgeon...
  88. doi Chemo-enzymatic synthesis of degradable PTMC-b-PECA-b-PTMC triblock copolymers and their micelle formation for pH-dependent controlled release
    Sachiko Kaihara
    Department of Applied Chemistry, Keio University, Yokohama 223 8522, Japan
    Macromol Biosci 9:613-21. 2009
    ..A drug release study showed that the release rate increased as the pH of the buffer decreased due to the degradation of the cyclic acetal segments, indicating its high utility for pH-sensitive controlled release...
  89. doi Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications
    Jie Han
    College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, PR China
    Int J Pharm 382:215-21. 2009
    ....
  90. doi Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum
    Toshihiro Murata
    Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    J Nat Prod 72:1379-84. 2009
    ..The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM)...
  91. doi Structural behavior of alcohol-1,4-dioxane mixtures through dielectric properties using TDR
    Ashok C Kumbharkhane
    School of Physical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, India
    J Phys Chem A 113:10196-201. 2009
    ..The binding energies for alcohol-alcohol (pair 11) and alcohol-DX (pair 12) are estimated to be -13.98 and -16.25 kJ/mol, respectively. The results have also been compared with previous results of the ethyleneglycol-DX system...
  92. ncbi Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage
    R Loch MacDonald
    University of Toronto, St Michael Hospital, Division of Neurosurgery, Keenan Research Centre, Toronto, Ontario, Canada
    Expert Opin Investig Drugs 17:1761-7. 2008
    ..All patients will undergo neurosurgical aneurysm clipping and outcome will be assessed primarily based on mortality and vasospasm-related morbidity...
  93. doi Organocatalytic approach to amphiphilic comb-block copolymers capable of stereocomplexation and self-assembly
    Kazuki Fukushima
    IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, USA
    Biomacromolecules 9:3051-6. 2008
    ..3) were prepared with up to 8-PLA branches. Mixtures of the D- and L-lactide based copolymers were studied to understand the effect of noncovalent interactions or stereocomplexation on the properties...
  94. doi Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between ox
    Ralf A Benndorf
    Clinical Pharmacology Unit, Department of Pharmacology, University Hospital Hamburg, Hamburg, Germany
    Circ Res 103:1037-46. 2008
    ..By this mechanism, isoprostanes may contribute directly to exacerbation of coronary heart disease and to capillary rarefaction in disease states of increased oxidative stress...
  95. doi The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism
    Mary L Garcia-Cazarin
    Department of Molecular and Biomedical Pharmacology, The University of Kentucky College of Medicine, 800 Rose St, UKMC MS 305, Lexington, KY 40536 0084, USA
    Mol Pharmacol 74:1000-7. 2008
    ..The data also provide evidence of a linkage between the alpha1D-AR and p53...
  96. doi Practical asymmetric conjugate alkynylation of Meldrum's acid-derived acceptors: access to chiral beta-alkynyl acids
    Sheng Cui
    Department of Chemical Process Research and Development, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Am Chem Soc 132:436-7. 2010
    ..The process provides practical access to chiral beta-alkynyl acids. Noteworthy attributes of the method are its broad scope, high functional-group compatibility, and ease of scalability...
  97. doi Evaluation of the biodegradation potential of 1,4-dioxane in river, soil and activated sludge samples
    Kazunari Sei
    Division of Sustainable Energy and Environmental Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Biodegradation 21:585-91. 2010
    ..However, most of the samples (14/20) were not able to degrade 1,4-dioxane degradation. Thus, it can be concluded that the potential for 1,4-dioxane degradation is not ubiquitously distributed in natural environment...
  98. pmc The contribution of chemical exchange to MRI frequency shifts in brain tissue
    Karin Shmueli
    Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 65:35-43. 2011
    ..The exchange-dependent contribution may report on tissue chemical composition and pH...
  99. pmc Comparison of closure of gastric perforation ulcers with biodegradable lactide-glycolide-caprolactone or omental patches
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    JSLS 13:550-4. 2009
    ..This technique could have utility in laparoscopic repair, as it does not require sutures or mobilization of the omentum...
  100. doi Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model
    David Spector
    Department of Surgery, Tufts Medical Center, 800 Washington St, Box 437, Boston, MA 02111, USA
    Surg Endosc 25:1148-52. 2011
    ..This study examined the intrinsic hemostatic properties of two different types of material used in buttressing in an accepted hemostasis model that does not involve stapling or its effects by compression...
  101. ncbi Determination of 1,4-dioxane in household detergents and cleaners
    Akiko Tanabe
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, 265 1 Higashijima, Akiha ku, Niigata 956 8603, Japan
    J AOAC Int 91:439-44. 2008
    ..2 mg/kg, which was higher than the 0.39 mg/kg mean for the other surfactants. Moreover, the 1,4-dioxane load/person was estimated to be 0.061 mg/day/person in Japan, which was 27% of the load from the domestic effluent...

Research Grants111 found, 100 shown here

  1. 4-ACETOXY-1, 3-DIOXANES IN MACROLIDE SYNTHESIS
    Scott Rychnovsky; Fiscal Year: 2001
    ..The methods developed in this grant will set a new standard for efficiency and convergence in the synthesis of highly oxygenated natural products, and will be applicable to the synthesis of other compounds of biological interest. ..
  2. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2001
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  3. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2000
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  4. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1999
    ..Results will provide a basis for understanding the failure of mechanisms for ventilatory neurogenesis, in apneas of neonates and adults. ..
  5. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  6. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2007
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." ..
  7. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2006
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  8. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2010
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..
  9. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2005
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  10. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    ..abstract_text> ..
  11. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2004
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  12. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2003
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apneas" or the "sudden infant death syndrome." ..
  13. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1993
    ....
  14. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1992
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  15. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1993
    ..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...
  16. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 1990
    ..We believe that results of studies proposed herein will provide significant insights into the mechanisms responsible for the neurogenesis of automatic ventilatory activity...
  17. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2000
    ....
  18. Small-Molecule Probes for Conditional Modulation of the Synapse Proteome
    Stephen Haggarty; Fiscal Year: 2007
    ..In the future chemical biology in general, and chemical genetics in particular, will play an important role in catalyzing new discoveries and potentially insight into function of the nervous system. ..
  19. THIOREDOXIN INHIBITION OF APOPTOSIS AND CANCER TREATMENT
    Garth Powis; Fiscal Year: 2006
    ..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer ..
  20. Cancer Drugs Active Against Stress Signaling Pathways
    Garth Powis; Fiscal Year: 2007
    ....
  21. Survival Signals for Molecular Target Assessment
    Garth Powis; Fiscal Year: 2006
    ..The work will provide important insights into the way these new types of agents can be developed and how their clinical trial should be conducted. ..
  22. THIOREDOXIN INHIBITION OF APOPTOSIS AND CANCER TREATMENT
    Garth Powis; Fiscal Year: 2007
    ..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer. city, state) ..
  23. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    Kathleen Derwin; Fiscal Year: 2009
    ....
  24. Redox Signaling and Cancer Drug Action
    Garth Powis; Fiscal Year: 2010
    ..The role of the pathways in human cancer will be confirmed to allow the identification of new molecular targets for cancer drug discovery and new strategies to treat cancer. ..
  25. THIOREDOXIN REDUCTASES AND CANCER
    Garth Powis; Fiscal Year: 2001
    ....
  26. THIOREDOXIN INHIBITION OF APOPTOSIS AND CANCER TREATMENT
    Garth Powis; Fiscal Year: 2003
    ..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer ..
  27. Small-molecule probes of chromatin-mediated neuroplasticity
    Stephen Haggarty; Fiscal Year: 2009
    ..These multidisciplinary studies will shed new light on molecular mechanisms of brain plasticity and the relevance of these mechanisms to the development of novel therapeutics for their treatment of memory and mood disorders. ..
  28. Chemoprevention by a Targeted Thioredoxin Inhibitor.
    Garth Powis; Fiscal Year: 2010
    ..The information obtained will be used for the clinical development of PX-12 as a cancer preventive agent for patients at high risk or with early disease. ..
  29. Clinically relevant large animal model of rotator cuff injury and repair
    Kathleen Derwin; Fiscal Year: 2007
    ..Successful development of this model would lead to important studies of critical factors thought to affect the outcome of this common clinical problem such as surgical technique, tear morphology and timing. ..
  30. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003
    ..abstract_text> ..
  31. Novel Inhibitors of Akt Signaling in Pancreatic Cancer
    Garth Powis; Fiscal Year: 2009
    ..The PtdIns-3-kinase/Akt signaling pathway is upregulated in many pancreatic cancers making it an ideal target for drugs to treat the disease. ..
  32. THIOREDOXIN INHIBITION OF APOPTOSIS AND CANCER TREATMENT
    Garth Powis; Fiscal Year: 2001
    ..These studies will focus on human leukemia, but the findings will be applicable to other forms of human cancer where thioredoxin is over- expressed. ..