dioxanes

..Although both copolymers are non-cytotoxic, the sample having the higher MBC content is the preferred composition based upon MDA levels and morphological evaluations...

..A general assessment showed better results for polyglycolic acid and Glycomer 631, while the other three materials presented slightly inferior performance, particularly polygalactic acid (inferior stitch resistance)...

..Herein we describe a series of novel, selective OX(2)R antagonists consisting of substituted 4-phenyl-[1,3]dioxanes. One such antagonist is compound 9, 1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-..

..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...

..a series of semisynthetic derivatives in order to gain insights into the structural requirements of simple 1,2-dioxanes for exhibiting antimalarial activity...

..We have developed a split--pool synthesis leading to an array of stock solutions of single 1,3-dioxanes. The quantities of compounds are sufficient for hundreds of phenotypic and protein-binding assays...

..It can be concluded that enzymatic degradation plays an important role in the surface erosion of PTMC in vivo...

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..Coccoid bacteria within biofilms were seen. The growth of Prevotella intermedia was much better on Deknalon than on Monocryl. The risk of bacteremia at the time of suture removal is discussed...

..A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications...

..Such biological behavior must be considered during the selection of the suture material to be used in oral surgery...

..T, relaxation is dominated by trans-gauche isomerisation, with an activation energy of 34-35 kJ mol(-1)...

..During bladder surgery, exposure of suture material that degrades via hydrolysis to urine containing Proteus spp should be minimized...

..Such networks, built up of non-toxic compounds and designed to release benign degradation products, may find wide application in tissue engineering and other areas of biomedical research...

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..A strong initial burst was found in all cases. Only a weak initial burst and a more continuous release was observed when networks of random L-lactide/epsilon-caprolactone copolymers were studied under the same conditions...

..They are very promising vehicles for the oral delivery of poorly water-soluble drugs...

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..After prolonged compressive deformation, solid and porous poly(ST-TMC-ST) discs showed significantly better recovery behaviour than poly(TMC) discs...

..This gelation effect was greater at high polymer concentrations and low quenching temperatures. The macroporous expected scaffold could be optimized from the slow development of phase separation during the long coarsening process...

..In this study, the suitability of different alloplastic and xenogenic biomaterials as scaffolds for ex vivo osteoblast cultivation was investigated...

..Finally, their enzymatic degradation revealed that PTMC nanoparticles degraded faster than those made of PCL...

..To present relevant mechanical data to simplify the selection of an osteofixation system for situations requiring immobilization in oral and maxillofacial surgery...

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..This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred...

..In the experimental application of this member to preventing adhesion after rabbit intestine operation, the membrane demonstrated good effect. In conclusion, PLA/PTMC blends membrane is a material with good biocompatibility...

..The study showed that the polymer substrate could influence the differentiation and growth of pluripotent stem cells in the absence of exogenous biochemical signals...

..Friction images showed differences in surface properties between the recessed and protruding lines in the pattern...

..The external sutures done with poliglecaprone 25 showed a greater tissue reaction; on the external sutures the tissue reaction decreased while the thread was being absorbed...

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..Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions...

..Time-conversion curves and MALDI-TOF mass spectrometry of homopolymerization suggest that SnOct(2) is the more efficient transesterification catalyst. A hypothetical reaction mechanism is discussed...

..Compound 11c (Lecozotan) was selected for further development and is currently in clinical trials...

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..These results demonstrate that surface-modified PGCL scaffold can provide a suitable substrate for fibroblast culture, especially in the case of soft tissue regenerations...

..Cylindrical photocured constructs prepared by photoirradiation to the whole body in a mold filled with the liquid copolymer was demonstrated as an example of shape fabrication of biodegradable biomedical devices...

..Anti-inflammatory drug (indomethacin) loading into microneedle-structured surfaces minimized inflammatory reactions. The possible biomedical microarchitectural three dimensinal in biomedical application photoconstructs was discussed...

..Stress-strain measurements showed the elastomeric character of these biodegradable multiblock copolymers, particularly in copolymers having epsilon-caprolactone as comonomer in the poly(TMC) blocks...

..The use of BSG as a staple-line reinforcer appears to be safe and may be useful in preventing anastomotic leakage, bleeding, and intraluminal stenosis...

..This study evaluated the ability of poliglecaprone 25 suture with triclosan to inhibit bacterial colonization by Escherichia coli and Staphylococcus aureus in mouse and guinea pig models...

..Based on these findings we do not feel Dermabond is an acceptable alternative to subcuticular suture closure in inguinal herniorrhaphy incisions...

..To assess the value of octyl-2-cyanoacrylate tissue glue in lip closure versus Monocryl stitches...

..This study was undertaken to evaluate the integrity of the loop-to-strand knot when tied with square and nonidentical sliding knots...

..A multifilament absorbable suture is usually used. The aim of this experimental work on rats was to study the benefits of using a monofilament absorbable suture with high initial resistance...

..Also, the ideal suturing technique (interrupted v continuous) according to the physical characteristics of the suture material and the optimal length for laparoscopic sutures were determined...

..This study compared the security of the knots and ultimate tensile strength of braided caprolactone/glycolide suture to that of a commonly used suture material, braided polyester (Ethibondtrade mark)...

..It is proposed that novel alpha(1A) antagonists should be designed with no 5-HT(1A) activity to achieve maximal relaxant effect...

..Proper patient and lesion selection aids in obtaining an acceptable outcome. CONCLUSION: The series spiral advancement flap has the potential to become a useful and common surgical technique...

..This suggests that the higher cooling rate due to lower cooling temperature can produce smaller ice-crystals and result in smaller pores...

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..Partition and diffusion coefficients are also estimated...

..In this paper, we discuss their potential biomedical applications...

..by a computer program, suggest that the oxidized intermediates resemble hydroperoxides or cyclic peroxides (1,2-dioxanes)...

..Events produced by creosote, dioxanes and dioxolanes, dicylopentadiene, and diacetyl, among the anthropogenic compounds; geosmin, MIB and iodinated ..

..The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to optically enriched dihydroxy 1,2-dioxanes 4...

..for the analysis of total 1,3-octanediols in apple juices by means of derivatization reaction to volatile 1,3-dioxanes. The derivatization reaction, SPME conditions, glycosidically bound fraction and 1,3-nonanediol as a surrogate ..

An anti-selective hydroformylation of 2-propylidene-substituted 1,3-dioxanes 16, 17, and 26 with excellent levels of acyclic stereocontrol has been achieved...

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..Taken together, these electrophysiological and behavioral findings indicate that B-HT 920 possesses the properties of a selective D2 DA receptor agonist and cannot be considered as a DA autoreceptor-selective compound...

..The fact that the functional alpha(1D)-adrenoceptor could not be detected in spite of the presence of the corresponding mRNA, remains to be investigated...

..The object of this study was to assess the risk of stricture for two types of resorbable suture (multifilament and monofilament) in a series of LRYGBPs performed by the same surgeon...

..abstract truncated at 250 words)..

..We conclude that central noradrenergic neurons exert a powerful suppressant action, most probably mediated via an alpha 2 adrenergic receptor, on seizure development in rapid hippocampal kindling...

..The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM)...

..This study examined the intrinsic hemostatic properties of two different types of material used in buttressing in an accepted hemostasis model that does not involve stapling or its effects by compression...

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..This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine...

..However, in the absence of a selective agonist it is unclear whether this ligand is an agonist or an antagonist at I2 receptors...

..Complete degradation of microspheres during 6 weeks was observed after the implantation to brain tissue. All implanted copolymers are compatible with brain tissue...

..It is concluded that MK 912, RX 821002, efaroxan and benoxathian are antagonists with high power to differentiate alpha 2A-from alpha 2D-adrenoceptors...

..Regionally different expression of alpha 1-adrenoceptor subtypes may be in part associated with the regional heterogeneity of sympathetic responses in the blood vessels...

..6. The slow i.p.s.p. could still be recorded from submucous plexus neurones in segments of ileum which had been extrinsically denervated 6-11 days previously.(ABSTRACT TRUNCATED AT 250 WORDS)..

..A drug release study showed that the release rate increased as the pH of the buffer decreased due to the degradation of the cyclic acetal segments, indicating its high utility for pH-sensitive controlled release...

..All patients will undergo neurosurgical aneurysm clipping and outcome will be assessed primarily based on mortality and vasospasm-related morbidity...

..The binding energies for alcohol-alcohol (pair 11) and alcohol-DX (pair 12) are estimated to be -13.98 and -16.25 kJ/mol, respectively. The results have also been compared with previous results of the ethyleneglycol-DX system...

..This agent could be used to treat early mnesic deficits observed in normal aging or in neurodegenerative disorders like Alzheimer disease...

..By this mechanism, isoprostanes may contribute directly to exacerbation of coronary heart disease and to capillary rarefaction in disease states of increased oxidative stress...

..3) were prepared with up to 8-PLA branches. Mixtures of the D- and L-lactide based copolymers were studied to understand the effect of noncovalent interactions or stereocomplexation on the properties...

..On the basis of these results, it was determined that the composite scaffold design was a viable alternative to the current approaches used for ligament tissue engineering and merits further study...

..The data also provide evidence of a linkage between the alpha1D-AR and p53...

..We conclude from these results that the suppression of LH release during acute fasting is mediated by alpha 2-adrenergic receptors but not alpha 1- or beta-adrenergic receptors...

..Suturing techniques are one of the most commonly used means to reshape the nasal cartilage; however, no data exist regarding the optimal suture material and its long-term effect...

..2 mg/kg, which was higher than the 0.39 mg/kg mean for the other surfactants. Moreover, the 1,4-dioxane load/person was estimated to be 0.061 mg/day/person in Japan, which was 27% of the load from the domestic effluent...

..This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-A(y) mice...

..30% in 30 days) related to the degradation of the amorphous part, followed by a negligible weight loss in the next days (few percent from 30 to 60 days)...

..alpha 2-Adrenoceptors are not essential for the effect of i.c.v. prostanoids on gastric acid secretion...

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..2%). CONCLUSION: These results suggest a coupling of alpha 1A-adrenoceptors in renal vascular tissue to the heterotrimeric Gs-protein and to heterotrimeric G-proteins of the G1- and/or G0-family in the phenylephrine-induced contraction...

..Furthermore, by obviating the need for suture removal, use of the BCS pattern may eliminate the requirement for this return appointment...

..Thus, in addition to their use for solubilizing hydrophobic substrates in water, cosolvents may also serve as activators in applications involving thermostable biocatalysts at sub-optimal temperatures...

..However, most of the samples (14/20) were not able to degrade 1,4-dioxane degradation. Thus, it can be concluded that the potential for 1,4-dioxane degradation is not ubiquitously distributed in natural environment...

..This technique could have utility in laparoscopic repair, as it does not require sutures or mobilization of the omentum...

..These findings suggest that MKC-242 increases the exploratory activity of mice in the elevated plus-maze via activation of 5-HT(1A) receptors, probably the presynaptic autoreceptors...

..The present results indicate that the pressor response to local injection of NA within the CC is independent of sympathetic nerve activation and is mediated by vasopressin release...

We use the structural dissection of two 1,3-dioxanes with in-cell histone deacetylase (HDAC) paralog selectivity to identify key elements for selective HDAC inhibitors...

..On the whole, these results indicate that chlordimeform-induced depression of motor activity in the guinea-pig ileum is, at least in part, related to inhibition of transmembrane Ca2+ fluxes responsible for smooth muscle contraction...

..The exchange-dependent contribution may report on tissue chemical composition and pH...

..The methods developed in this grant will set a new standard for efficiency and convergence in the synthesis of highly oxygenated natural products, and will be applicable to the synthesis of other compounds of biological interest. ..

..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..

..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..

..Results will provide a basis for understanding the failure of mechanisms for ventilatory neurogenesis, in apneas of neonates and adults. ..

..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..

..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." ..

..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..

..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..

..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..

..abstract_text> ..

..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..

..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apneas" or the "sudden infant death syndrome." ..

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..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...

..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...

..We believe that results of studies proposed herein will provide significant insights into the mechanisms responsible for the neurogenesis of automatic ventilatory activity...

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..In the future chemical biology in general, and chemical genetics in particular, will play an important role in catalyzing new discoveries and potentially insight into function of the nervous system. ..

..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer ..

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..The work will provide important insights into the way these new types of agents can be developed and how their clinical trial should be conducted. ..

..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer. city, state) ..

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..The role of the pathways in human cancer will be confirmed to allow the identification of new molecular targets for cancer drug discovery and new strategies to treat cancer. ..

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..The objective of our studies is to investigate mechanisms for Trx inhibition of apoptosis and develop novel inhibitors of Trx we have identified as potential agents for the treatment of cancer ..

..These multidisciplinary studies will shed new light on molecular mechanisms of brain plasticity and the relevance of these mechanisms to the development of novel therapeutics for their treatment of memory and mood disorders. ..

..The information obtained will be used for the clinical development of PX-12 as a cancer preventive agent for patients at high risk or with early disease. ..

..Successful development of this model would lead to important studies of critical factors thought to affect the outcome of this common clinical problem such as surgical technique, tear morphology and timing. ..

..abstract_text> ..

..The PtdIns-3-kinase/Akt signaling pathway is upregulated in many pancreatic cancers making it an ideal target for drugs to treat the disease. ..

..These studies will focus on human leukemia, but the findings will be applicable to other forms of human cancer where thioredoxin is over- expressed. ..