dioxanes

Summary

Summary: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)

Top Publications

  1. ncbi Evaluation of novel biodegradable cyclic carbonate polyester copolymers for cytocompatibility using MRC-5 cells
    J Longino
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 39:306-11. 2003
  2. ncbi [Comparison of five synthetic absorbable suture materials in intestinal anastomosis: experimental study in rats]
    Carlo De Werra
    Cattedra di Chirurgia Generale, Universita degli Studi di Napoli Federico II, Napoli
    Chir Ital 55:227-33. 2003
  3. ncbi Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
  4. ncbi Tripropyltin(iv) complexes with some selected bioligands in 50% v/v dioxane/water mixture
    Abdul Aziz Al-Najjar
    Department of Applied Sciences, Faculty of Technological Studies, PO Box 42325, 70654 Shuwaikh, Kuwait
    Ann Chim 96:97-107. 2006
  5. ncbi Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series
    M Barth
    Department of Neurosurgery, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Acta Neurochir (Wien) 149:911-8; discussion 918. 2007
  6. pmc Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
    Jason R Harris
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Lett 11:3290-3. 2009
  7. ncbi Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats
    Gerrit A Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 109:1134-40. 2008
  8. ncbi Patient age and vasospasm after subarachnoid hemorrhage
    Mats Ryttlefors
    Department of Neuroscience, Section for Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 67:911-7. 2010
  9. ncbi Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists
    Laura C McAtee
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:4225-9. 2004
  10. ncbi The in vivo and in vitro degradation behavior of poly(trimethylene carbonate)
    Zheng Zhang
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:1741-8. 2006

Detail Information

Publications216 found, 100 shown here

  1. ncbi Evaluation of novel biodegradable cyclic carbonate polyester copolymers for cytocompatibility using MRC-5 cells
    J Longino
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 39:306-11. 2003
    ..Although both copolymers are non-cytotoxic, the sample having the higher MBC content is the preferred composition based upon MDA levels and morphological evaluations...
  2. ncbi [Comparison of five synthetic absorbable suture materials in intestinal anastomosis: experimental study in rats]
    Carlo De Werra
    Cattedra di Chirurgia Generale, Universita degli Studi di Napoli Federico II, Napoli
    Chir Ital 55:227-33. 2003
    ..A general assessment showed better results for polyglycolic acid and Glycomer 631, while the other three materials presented slightly inferior performance, particularly polygalactic acid (inferior stitch resistance)...
  3. ncbi Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
    ....
  4. ncbi Tripropyltin(iv) complexes with some selected bioligands in 50% v/v dioxane/water mixture
    Abdul Aziz Al-Najjar
    Department of Applied Sciences, Faculty of Technological Studies, PO Box 42325, 70654 Shuwaikh, Kuwait
    Ann Chim 96:97-107. 2006
    ..The participation of different ligand functional groups in binding to organotin is discussed. The speciation diagrams of the various complex species were evaluated as a function of pH...
  5. ncbi Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series
    M Barth
    Department of Neurosurgery, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Acta Neurochir (Wien) 149:911-8; discussion 918. 2007
    ..To study the effects of clazosentan, a new selective endothelin receptor subtype A antagonist, on cerebral perfusion and cerebral oxygenation following severe aneurysmal subarachnoid haemorrhage (aSAH)...
  6. pmc Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
    Jason R Harris
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Lett 11:3290-3. 2009
    ..of gamma,delta-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products...
  7. ncbi Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats
    Gerrit A Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 109:1134-40. 2008
    ..The purpose of this study was to further determine the role of ET in the first minutes to hours after massive experimental SAH induced by prophylactic treatment with the ET receptor antagonist clazosentan...
  8. ncbi Patient age and vasospasm after subarachnoid hemorrhage
    Mats Ryttlefors
    Department of Neuroscience, Section for Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 67:911-7. 2010
    ..Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating disease with high mortality and morbidity. The incidence of SAH increases with advancing age...
  9. ncbi Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists
    Laura C McAtee
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:4225-9. 2004
    ..Herein we describe a series of novel, selective OX(2)R antagonists consisting of substituted 4-phenyl-[1,3]dioxanes. One such antagonist is compound 9, 1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-..
  10. ncbi The in vivo and in vitro degradation behavior of poly(trimethylene carbonate)
    Zheng Zhang
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:1741-8. 2006
    ..It can be concluded that enzymatic degradation plays an important role in the surface erosion of PTMC in vivo...
  11. ncbi Randomized clinical trial comparing a polypropylene with a poliglecaprone and polypropylene composite mesh for inguinal hernioplasty
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, 7 Debinki Street, 80 211 Gdansk, Poland
    Br J Surg 95:1462-8. 2008
    ..The aim was to assess whether a partially absorbable monofilament mesh could influence postoperative pain and time to return to normal activity after Lichtenstein hernioplasty...
  12. ncbi In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or epsilon-caprolactone: Degradation and tissue response
    A P Pêgo
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Chemical Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Biomed Mater Res A 67:1044-54. 2003
    ....
  13. ncbi Tolerability, pharmacokinetics, and pharmacodynamics of clazosentan, a parenteral endothelin receptor antagonist
    Paul L M van Giersbergen
    Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 18, 4123 Allschwil, Switzerland
    Eur J Clin Pharmacol 63:151-8. 2007
    ..The purpose of this study was to investigate in healthy male subjects the tolerability, pharmacokinetics, and pharmacodynamics of ascending doses of clazosentan, an intravenous endothelin receptor antagonist...
  14. ncbi Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes
    Jason C Wong
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Biol 11:1279-91. 2004
    Modular synthesis and substrate stereocontrol were combined to furnish 18,000 diverse 1,3-dioxanes whose distribution in chemical space rivals that of a reference set of over 2,000 bioactive small molecules...
  15. ncbi Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
    ..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...
  16. ncbi Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, The Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA
    Bioorg Med Chem Lett 15:3207-11. 2005
    ..Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1mM...
  17. ncbi Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays
    S M Sternson
    Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Chem Soc 123:1740-7. 2001
    ..We have developed a split--pool synthesis leading to an array of stock solutions of single 1,3-dioxanes. The quantities of compounds are sufficient for hundreds of phenotypic and protein-binding assays...
  18. pmc Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication
    Ha Young Kim
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, The Purdue Cancer Center, West Lafayette, IN 47907, USA
    Bioorg Med Chem 15:2667-79. 2007
    ..4 microM as an inhibitor of Sindbis virus replication. Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1mM...
  19. ncbi Three-year follow-up of modified Lichtenstein inguinal hernioplasty using lightweight poliglecaprone/polypropylene mesh
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, ul Debinki 7, 80 211, Gdansk, Poland
    Hernia 13:239-42. 2009
    ....
  20. ncbi Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
    J Neurosurg 115:1191-6. 2011
    ..Numerous abnormal findings may be evident on CT scans after aneurysmal subarachnoid hemorrhage (SAH). Here, the authors assess the interobserver variability in the radiological interpretation of the initial CT scan following SAH...
  21. ncbi Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents
    Caterina Fattorusso
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Med Chem 49:7088-94. 2006
    ..a series of semisynthetic derivatives in order to gain insights into the structural requirements of simple 1,2-dioxanes for exhibiting antimalarial activity...
  22. ncbi CAPROSYN*, another major advance in synthetic monofilament absorbable suture
    Angela Pineros-Fernandez
    University of Virginia Health System, Charlottesville, Virginia 22908 1351, USA
    J Long Term Eff Med Implants 14:359-68. 2004
    ....
  23. ncbi Creep-resistant porous structures based on stereo-complex forming triblock copolymers of 1,3-trimethylene carbonate and lactides
    Zheng Zhang
    Institute for Biomedical Technology BMTI, Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The Netherlands
    J Mater Sci Mater Med 15:381-5. 2004
    ..After prolonged compressive deformation, solid and porous poly(ST-TMC-ST) discs showed significantly better recovery behaviour than poly(TMC) discs...
  24. ncbi Biodegradable, elastic shape-memory polymers for potential biomedical applications
    Andreas Lendlein
    mnemoScience GmbH, Pauwelsstrabetae 19, D 52074 Aachen, Germany
    Science 296:1673-6. 2002
    ..A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications...
  25. ncbi Resorbable plates for the fixation of mandibular fractures: a prospective study
    Robert M Laughlin
    Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA, USA
    J Oral Maxillofac Surg 65:89-96. 2007
    ....
  26. ncbi [Biological properties study and animal experiment of polylactide/polytrimethylene carbonate blends membrane]
    Xiaoqiang Yang
    Research Institute of Daily Chemistry of China, Taiyuan 030024, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:578-82. 2006
    ..In the experimental application of this member to preventing adhesion after rabbit intestine operation, the membrane demonstrated good effect. In conclusion, PLA/PTMC blends membrane is a material with good biocompatibility...
  27. ncbi Comparative study of tissue response to polyglecaprone 25, polyglactin 910 and polytetrafluorethylene suture materials in rats
    Hugo Nary Filho
    Department of Oral Surgery, School of Dentistry, Sacred Heart University USC, Bauru, SP, Brazil
    Braz Dent J 13:86-91. 2002
    ..Such biological behavior must be considered during the selection of the suture material to be used in oral surgery...
  28. ncbi Enhanced extracellular matrix production and differentiation of human embryonic germ cell derivatives in biodegradable poly(epsilon-caprolactone-co-ethyl ethylene phosphate) scaffold
    Evelyn K F Yim
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Acta Biomater 2:365-76. 2006
    ..The study showed that the polymer substrate could influence the differentiation and growth of pluripotent stem cells in the absence of exogenous biochemical signals...
  29. ncbi Biodegradable self-assembling PEG-copolymer as vehicle for poorly water-soluble drugs
    Louisa Ould-Ouali
    Universite Catholique de Louvain, Department of Pharmaceutical Technology, Brussels, Belgium
    Pharm Res 21:1581-90. 2004
    ..To develop self-assembling systems increasing the solubility of poorly water-soluble drugs...
  30. ncbi 1H and 13C NMR studies of molecular dynamics in the biocopolymer of glycolide and epsilon-caprolactone
    Farhod Nozirov
    Department of Macromolecular Physics, Adam Mickiewicz University, Poznan, Poland
    Solid State Nucl Magn Reson 22:19-28. 2002
    ..T, relaxation is dominated by trans-gauche isomerisation, with an activation energy of 34-35 kJ mol(-1)...
  31. ncbi The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tissue
    Dorothee Rickert
    Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Prittwitzstr 43, 89075 Ulm, Germany
    Clin Hemorheol Microcirc 28:175-81. 2003
    ....
  32. ncbi Macroporous poly(L-lactide) scaffold 1. Preparation of a macroporous scaffold by liquid--liquid phase separation of a PLLA--dioxane--water system
    Feng Jun Hua
    Center for Advanced Functional Polymers, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Kyungki 440 746, Korea
    J Biomed Mater Res 63:161-7. 2002
    ..This gelation effect was greater at high polymer concentrations and low quenching temperatures. The macroporous expected scaffold could be optimized from the slow development of phase separation during the long coarsening process...
  33. ncbi Polylactones 57. Biodegradable networks based on A-B-A triblock segments containing poly(ethylene glycol)s-syntheses and drug release properties
    Hans R Kricheldorf
    Institut fur Technische und Makromolekulare Chemie, Bundesstr 45, D 20146 Hamburg, Germany
    Biomacromolecules 4:950-5. 2003
    ..A strong initial burst was found in all cases. Only a weak initial burst and a more continuous release was observed when networks of random L-lactide/epsilon-caprolactone copolymers were studied under the same conditions...
  34. ncbi Surface functionalization of degradable polymers by covalent grafting
    Martina Källrot
    School of Chemical Science and Engineering, Royal Institute of Technology, Fibre and Polymer Technology, SE 100 44 Stockholm, Sweden
    Biomaterials 27:1788-96. 2006
    ....
  35. ncbi Loading and release of ibuprofen in multi- and monofilament surgical sutures
    Raül Zurita
    Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, Av Diagonal 647, E 08028, Barcelona, Spain
    Macromol Biosci 6:767-75. 2006
    ..This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred...
  36. ncbi Evaluation of the tensile strengths of four monofilament absorbable suture materials after immersion in canine urine with or without bacteria
    Chelsea B Greenberg
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 65:847-53. 2004
    ..To evaluate the tensile strength, elongation, and degradation of 4 monofilament absorbable suture materials that undergo degradation by hydrolysis in specimens of canine urine with various physical characteristics...
  37. ncbi Preparation of biodegradable networks by photo-crosslinking lactide, epsilon-caprolactone and trimethylene carbonate-based oligomers functionalized with fumaric acid monoethyl ester
    Dirk W Grijpma
    Faculty of Science and Technology, Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 26:2795-802. 2005
    ..Such networks, built up of non-toxic compounds and designed to release benign degradation products, may find wide application in tissue engineering and other areas of biomedical research...
  38. ncbi Enzymatic surface erosion of poly(trimethylene carbonate) films studied by atomic force microscopy
    Zheng Zhang
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands
    Biomacromolecules 6:3404-9. 2005
    ..Friction images showed differences in surface properties between the recessed and protruding lines in the pattern...
  39. ncbi Different substitute biomaterials as potential scaffolds in tissue engineering
    Ljubinko Petrovic
    Oral and Maxillofacial Surgery Department, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Int J Oral Maxillofac Implants 21:225-31. 2006
    ..In this study, the suitability of different alloplastic and xenogenic biomaterials as scaffolds for ex vivo osteoblast cultivation was investigated...
  40. ncbi Bacterial colonization on different suture materials--a potential risk for intraoral dentoalveolar surgery
    J E Otten
    Klinik und Poliklinik fur Mund, Kiefer und Gesichtschirurgie, Albert Ludwigs Universitat Freiburg, Germany
    J Biomed Mater Res B Appl Biomater 74:627-35. 2005
    ..Coccoid bacteria within biofilms were seen. The growth of Prevotella intermedia was much better on Deknalon than on Monocryl. The risk of bacteremia at the time of suture removal is discussed...
  41. ncbi Thermoplastic elastomers based on poly(lactide)-poly(trimethylene carbonate-co-caprolactone)-poly(lactide) triblock copolymers and their stereocomplexes
    Z Zhang
    Institute for Biomedical Technology, Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands
    J Control Release 116:e29-31. 2006
  42. ncbi Mechanical strength and stiffness of biodegradable and titanium osteofixation systems
    Gerrit J Buijs
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Oral Maxillofac Surg 65:2148-58. 2007
    ..To present relevant mechanical data to simplify the selection of an osteofixation system for situations requiring immobilization in oral and maxillofacial surgery...
  43. ncbi Biodegradable polycarbonate-b-polypeptide and polyester-b-polypeptide block copolymers: synthesis and nanoparticle formation towards biomaterials
    Maude Le Hellaye
    Laboratoire de Chimie des Polymeres Organiques, LCPO, Université Bordeaux 1 CNRS ENSCPB, 16 Avenue Pey Berland, 33607 Pessac Cedex, France
    Biomacromolecules 9:1924-33. 2008
    ..Finally, their enzymatic degradation revealed that PTMC nanoparticles degraded faster than those made of PCL...
  44. ncbi Fabrication of porous particulate for the scaffold by applying solution spraying method
    Hideki Tamasaki
    Division of Dental Anesthesiology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Dent Mater J 24:76-82. 2005
    ..Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions...
  45. ncbi Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan
    Wayne E Childers
    Chemical and Screening Sciences and Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 48:3467-70. 2005
    ..Compound 11c (Lecozotan) was selected for further development and is currently in clinical trials...
  46. ncbi Fibroblast culture on surface-modified poly(glycolide-co-epsilon-caprolactone) scaffold for soft tissue regeneration
    I K Kwon
    Biomaterials Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul
    J Biomater Sci Polym Ed 12:1147-60. 2001
    ..These results demonstrate that surface-modified PGCL scaffold can provide a suitable substrate for fibroblast culture, especially in the case of soft tissue regenerations...
  47. ncbi Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). I. Preparation and visible light-induced photocuring characteristics
    Manabu Mizutani
    Department of Bioengineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Biomed Mater Res 62:387-94. 2002
    ..Cylindrical photocured constructs prepared by photoirradiation to the whole body in a mold filled with the liquid copolymer was demonstrated as an example of shape fabrication of biodegradable biomedical devices...
  48. ncbi Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). II. Computer-aided stereolithographic microarchitectural surface photoconstructs
    Takehisa Matsuda
    Department of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biomed Mater Res 62:395-403. 2002
    ..Anti-inflammatory drug (indomethacin) loading into microneedle-structured surfaces minimized inflammatory reactions. The possible biomedical microarchitectural three dimensinal in biomedical application photoconstructs was discussed...
  49. ncbi Multiblock copolymers of L-lactide and trimethylene carbonate
    Doris Pospiech
    Institut fur Technische und Makromolekulare Chemie, Bundesstrasse 45, D 20146 Hamburg, Germany
    Biomacromolecules 6:439-46. 2005
    ..Stress-strain measurements showed the elastomeric character of these biodegradable multiblock copolymers, particularly in copolymers having epsilon-caprolactone as comonomer in the poly(TMC) blocks...
  50. ncbi Safety and efficacy of the use of bioabsorbable seamguard in colorectal surgery at the Texas endosurgery institute
    Morris E Franklin
    Texas Endosurgery Institute, San Antonio, TX 78222, USA
    Surg Laparosc Endosc Percutan Tech 15:9-13. 2005
    ..The use of BSG as a staple-line reinforcer appears to be safe and may be useful in preventing anastomotic leakage, bleeding, and intraluminal stenosis...
  51. ncbi In vivo antibacterial efficacy of MONOCRYL plus antibacterial suture (Poliglecaprone 25 with triclosan)
    Xintian Ming
    Corporate Microbiology and Sterilization Sciences, Ethicon Inc, Somerville, NJ 08876, USA
    Surg Infect (Larchmt) 8:209-14. 2007
    ..This study evaluated the ability of poliglecaprone 25 suture with triclosan to inhibit bacterial colonization by Escherichia coli and Staphylococcus aureus in mouse and guinea pig models...
  52. ncbi Comparison of inflammatory response to polyglytone 6211 and polyglecaprone 25 in a rat model
    Johan van Heerden
    Department of Plastic Surgery, Ga Rankuwa Hospital, Pretoria, South Africa
    S Afr Med J 95:972-4. 2005
  53. ncbi Subcuticular closure versus Dermabond: a prospective randomized trial
    Erin F Switzer
    Department of Surgery, Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
    Am Surg 69:434-6. 2003
    ..Based on these findings we do not feel Dermabond is an acceptable alternative to subcuticular suture closure in inguinal herniorrhaphy incisions...
  54. ncbi Octyl-2-cyanoacrylate tissue glue (Dermabond) versus Monocryl 6 x 0 Sutures in lip closure
    Paul H M Spauwen
    Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    Cleft Palate Craniofac J 43:625-7. 2006
    ..To assess the value of octyl-2-cyanoacrylate tissue glue in lip closure versus Monocryl stitches...
  55. ncbi Tying a loop-to-strand suture: is it safe?
    Jason Hurt
    Division of Gynecologic Pelvic Surgery, Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Obstet Gynecol 192:1094-7. 2005
    ..This study was undertaken to evaluate the integrity of the loop-to-strand knot when tied with square and nonidentical sliding knots...
  56. ncbi Laparoscopic suturing: effect of instrument handling on suture strength
    Simon V Bariol
    Scottish Lithotriptor Centre, Western General Hospital, Edinburgh, UK
    J Endourol 19:1127-33. 2005
    ..Also, the ideal suturing technique (interrupted v continuous) according to the physical characteristics of the suture material and the optimal length for laparoscopic sutures were determined...
  57. ncbi [Tracheal anastomosis: monofilament absorbable suture versus monofilament non-absorbable suture. Experimental study in rats]
    D S Lazard
    Service ORL et Chirurgie Cervico Faciale, Hopital Foch, 40 rue Worth, 92151 Suresnes
    Ann Otolaryngol Chir Cervicofac 121:156-60. 2004
    ..A multifilament absorbable suture is usually used. The aim of this experimental work on rats was to study the benefits of using a monofilament absorbable suture with high initial resistance...
  58. ncbi Investigation of the role of the serotonergic activity of certain subtype-selective alpha1A antagonists in the relaxant effect on the pregnant rat uterus in vitro
    Attila Mihalyi
    University of Szeged, Faculty of Pharmacy, Department of Pharmacodynamics and Biopharmacy, H 6720 Szeged, Eotvos u 6, Hungary
    Mol Hum Reprod 9:475-80. 2003
    ..It is proposed that novel alpha(1A) antagonists should be designed with no 5-HT(1A) activity to achieve maximal relaxant effect...
  59. ncbi Strength and knot security of braided polyester and caprolactone/glycolide suture
    Christopher Bibbo
    Department of Orthopaedic Surgery, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
    Foot Ankle Int 25:712-5. 2004
    ..This study compared the security of the knots and ultimate tensile strength of braided caprolactone/glycolide suture to that of a commonly used suture material, braided polyester (Ethibondtrade mark)...
  60. ncbi Control of pore size in L-lactide/epsilon-caprolactone copolymer foams for tissue regeneration by the freeze-drying method
    Hiroyuki Nakao
    Division of Biomaterials Science, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dent Mater J 22:262-71. 2003
    ..This suggests that the higher cooling rate due to lower cooling temperature can produce smaller ice-crystals and result in smaller pores...
  61. ncbi Bioreabsorbable polymer scaffold as temporary meniscal prosthesis
    Ana Paula Testa Pezzin
    State University of Campinas, UNICAMP, Faculty of Mechanical Engineering, Campinas, SP, Brazil
    Artif Organs 27:428-31. 2003
    ....
  62. ncbi Triclosan release from coated polyglycolide threads
    Raül Zurita
    Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, 08028 Barcelona, Spain
    Macromol Biosci 6:58-69. 2006
    ..Partition and diffusion coefficients are also estimated...
  63. ncbi Photo-polymerized microarchitectural constructs prepared by microstereolithography (muSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers
    Il Keun Kwon
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biomaterials 26:1675-84. 2005
    ..In this paper, we discuss their potential biomedical applications...
  64. ncbi New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible?
    Seymour Lieberman
    Department of Obstetrics and Gynecology, Institute for Health Sciences, St Luke s Roosevelt Hospital Center, 432 West 58th Street, New York, NY 10019, USA
    J Steroid Biochem Mol Biol 94:405-20. 2005
    ..by a computer program, suggest that the oxidized intermediates resemble hydroperoxides or cyclic peroxides (1,2-dioxanes)...
  65. ncbi A review of taste and odour events in Barcelona's drinking water area (1990-2004)
    M R Boleda
    AGBAR, Aigues de Barcelona Avinguda Diagonal, 211, 08018 Barcelona, Spain
    Water Sci Technol 55:217-21. 2007
    ..Events produced by creosote, dioxanes and dioxolanes, dicylopentadiene, and diacetyl, among the anthropogenic compounds; geosmin, MIB and iodinated ..
  66. ncbi Dihydroxylation of 4-substituted 1,2-dioxines: a concise route to branched erythro sugars
    Tony V Robinson
    Department of Chemistry, The University of Adelaide, South Australia 5005, Australia
    J Org Chem 74:5093-6. 2009
    ..The asymmetric dihydroxylation of 1,2-dioxines was examined, providing access to optically enriched dihydroxy 1,2-dioxanes 4...
  67. ncbi A novel method for the determination of total 1,3-octanediols in apple juice via 1,3-dioxanes by solid-phase microextraction and high-speed gas chromatography
    Daniel Díaz Llorente
    Departamento de Quimica Fisica y Analitica, Universidad de Oviedo, c Julian Claveria 8, E 33006 Oviedo, Spain
    J Chromatogr A 1217:2993-9. 2010
    ..for the analysis of total 1,3-octanediols in apple juices by means of derivatization reaction to volatile 1,3-dioxanes. The derivatization reaction, SPME conditions, glycosidically bound fraction and 1,3-nonanediol as a surrogate ..
  68. ncbi Stereoselective hydroformylation: key step for the assembly of polypropionate subunits
    B Breit
    Organisch Chemisches Institut, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
    J Org Chem 66:4870-7. 2001
    An anti-selective hydroformylation of 2-propylidene-substituted 1,3-dioxanes 16, 17, and 26 with excellent levels of acyclic stereocontrol has been achieved...
  69. ncbi Novel single-phase and gram-scale synthesis of thiol-uncapped stable colloidal gold nanoparticles
    Xavier Jurvilliers
    Laboratoire de Synthèse Organométallique et Réactivité UMR 7565, Universite Henri Poincare, Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex, France
    J Nanosci Nanotechnol 5:282-7. 2005
    ..These clusters were further used for the production of monodisperse Au nanoparticles with controlled surface properties through ligand exchange with 1-dodecanethiol or 1-decylamine...
  70. ncbi Asymmetric synthesis and CD investigation of the 1,4-benzodioxane lignans eusiderins A, B, C, G, L, and M
    Lisa I Pilkington
    School of Chemical Sciences, University of Auckland, Auckland, New Zealand
    J Org Chem 77:8156-66. 2012
    ..This data will now allow for the determination of absolute stereochemistry of other members in this class of compound...
  71. ncbi Carcinogenicity studies of 1,4-dioxane administered in drinking-water to rats and mice for 2 years
    Hirokazu Kano
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, 2445 Hirasawa, Hadano, Kanagawa 257 0015, Japan
    Food Chem Toxicol 47:2776-84. 2009
    ....
  72. ncbi 5alpha,8alpha-epidioxysterols from a Formosan sponge, Axinyssa sp
    Tzu rong Su
    Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital, Pingtung 928, Taiwan
    Nat Prod Commun 8:1535-6. 2013
    ..Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines...
  73. ncbi [Clinical and histopathological study of tissue reactivity to monofilament suture materials: nylon and poliglecaprone 25 in rats]
    Camila Maria Beder Ribeiro
    Universidade Federal de Pernambuco, Recife, PE, Brazil
    Acta Cir Bras 20:284-91. 2005
    ..The aim of this experimental study was to evaluate through a clinical and histopathological analysis the tissue reactivity caused by two monofilament sutures nylon and poliglecaprone 25 on the internal and external sutures in rats...
  74. ncbi Copolymerizations of epsilon-caprolactone and glycolide-a comparison of tin(II)octanoate and bismuth(III)subsalicylate as initiators
    Hans R Kricheldorf
    Institut fur Technische und Makromolekulare Chemie, Bundesstr 45, D 20146 Hamburg, Germany
    Biomacromolecules 6:1345-52. 2005
    ..Time-conversion curves and MALDI-TOF mass spectrometry of homopolymerization suggest that SnOct(2) is the more efficient transesterification catalyst. A hypothetical reaction mechanism is discussed...
  75. ncbi Environmental effects on the aggregation of some xanthene dyes used in lasers
    Swati De
    Department of Chemistry, University of Kalyani, Kalyani 741235, Nadia, West Bengal, India
    Spectrochim Acta A Mol Biomol Spectrosc 61:1821-33. 2005
    ..These observations bear direct relevance to the possible use of fluorescein and eosin Y as quantum yield standards, photosensitizers, laser dyes and biological labels...
  76. ncbi Experimental and theoretical analysis of the kinetics of the reaction of atomic bromine with 1,4-dioxane
    Binod Raj Giri
    Department of Chemistry, Acadia, University, Wolfville, Nova Scotia B4P 2R6, Canada
    J Phys Chem A 114:291-8. 2010
    ..Comparison with results reported for the reactions of Br with other ethers suggests that this multistep mechanism differs significantly from that for abstraction of hydrogen from other ethers by atomic bromine...
  77. ncbi Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation
    Alessandro Piergentili
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    Bioorg Med Chem 17:8174-85. 2009
    ..Compounds 4, 5, and 8 might be valuable tools in the characterization of the M(3) receptor, as well as provide useful information for the design and development of novel selective M(3) antagonists...
  78. ncbi Autoradiographic studies of central alpha 2A- and alpha 2C-adrenoceptors in the rat using [3H]MK912 and subtype-selective drugs
    S Uhlen
    Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    Brain Res 770:261-6. 1997
    ..Using this approach, alpha 2C-adrenoceptors were detected in the striatum, while alpha 2A-adrenoceptors predominated in the cortical layers 1-4, the spinal cord distal dorsal horn, the septum and the endopiriform nucleus...
  79. ncbi An optical microscopy study on the phase structure of poly(L-lactide acid)/poly(propylene carbonate) blends
    Min Gao
    State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
    J Phys Chem B 116:9832-7. 2012
    ..It is further confirmed that the crystallization of PLLA in the blends is influenced by the different phase structures. For example, the crystallinity of PLLA in the blend increases with increasing heat-treatment temperature...
  80. ncbi The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis
    D Jovanovic-Micic
    Department of Pharmacology, Medical Faculty, Belgrade, Yugoslavia
    Eur J Pharmacol 272:21-30. 1995
    ..It appears, therefore, that the emetic effect of intracerebroventricular dopamine is mediated by adrenergic rather than dopaminergic mechanisms in the area postrema, at least in the cat...
  81. pmc Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites
    D Pinthong
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
    Br J Pharmacol 115:689-95. 1995
    ..Moreover, these extracts appear to possess a binding profile similar to that of adrenaline and UK-14304, suggesting that they may possess agonist activity...
  82. ncbi Binding properties, regional ontogeny and localization of adrenergic receptors in chick brain
    C R Dermon
    Department of Physiology, School of Medicine, University of Patras, Greece
    Int J Dev Neurosci 6:471-82. 1988
    ..Labelling of the granule cell layer was almost equally strong for alpha 1 but significantly less for beta binding sites. No significant labelling could be detected for alpha 2 binding sites...
  83. ncbi Methiothepin enhances the potassium-evoked release of [3H]-noradrenaline in rat pineal gland
    M A Taranger
    Department of Biology, Laboratoires d Etudes et de Recherches Synthélabo, Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 336:374-80. 1987
    ..The facilitation by methiothepin of the K+-evoked release of [3H]-noradrenaline in rat pineal gland appears to be due to the inhibition of noradrenaline uptake by this compound...
  84. ncbi Elastic multiblock copolymers for vascular regeneration: protein adsorption and hemocompatibility
    Rumiana Tzoneva
    Department Electro induced and adhesive properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Clin Hemorheol Microcirc 52:337-48. 2012
    ..The present results reveal that the tested multiblock copolymers with improved elastic properties and shape-memory capability (PDC) show low thrombogenicity and are promising candidates for vascular tissue engineering...
  85. ncbi Synthesis and characterization of amine-bridged bis(phenolate)lanthanide alkoxides and their application in the controlled polymerization of rac-lactide and rac-β-butyrolactone
    Kun Nie
    Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, People s Republic of China
    Inorg Chem 51:11133-43. 2012
    ..End-group analysis of the oligomer of rac-BBL suggested that elimination side reactions occurred slowly in these systems, which led to chain cleavage and the formation of crotonate (and carboxy) end groups...
  86. ncbi Short-term complications after vaginal prolapse surgery: do suture characteristics influence morbidity?
    A Patil
    Department of Obstetrics and Gynaecology, Medway NHS Foundation Trust, Gillingham, UK
    J Obstet Gynaecol 32:778-80. 2012
    ..000) or to be readmitted postoperatively (p=1.000). Size 1 multifilament sutures result in higher levels of postoperative morbidity when compared with 2/0 monofilament sutures...
  87. ncbi Intrathecal bradykinin acts presynaptically on spinal noradrenergic terminals to produce antinociception in the rat
    O Laneuville
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Eur J Pharmacol 159:273-83. 1989
    ..These results suggest that BK (kinins) may inhibit spinal nociceptive sensory transmission and produce analgesia by acting presynaptically on terminals of bulbospinal NA-containing fibers...
  88. ncbi Influence of ethnic origin and sex on the pharmacokinetics of clazosentan
    Paul L M van Giersbergen
    Actelion Pharmaceuticals Ltd, Department of Clinical Pharmacology, Gewerbestrasse 16, 4123 Allschwil, Switzerland
    J Clin Pharmacol 47:1374-80. 2007
    ..7 hours. The data suggest that Caucasian and Japanese patients can be treated with a similar dosing regimen of clazosentan. At the doses infused, administration of clazosentan was safe and well tolerated in both ethnic groups...
  89. ncbi [Central presynaptic receptors]
    E A Singer
    Pharmakologisches Institut, Universitat Wien
    Wien Klin Wochenschr 102:609-15. 1990
    ..Bilateral intraspinal injection of 5,7-DHT, which interrupts the medullo-spinal serotonergic pathway, markedly attenuated the effects of local intramedullary injection of 8-OH-DPAT.(ABSTRACT TRUNCATED AT 400 WORDS)..
  90. ncbi Physical properties and erosion behavior of poly(trimethylene carbonate-co-ε-caprolactone) networks
    Erhan Bat
    Department of Polymer Chemistry and Biomaterials, MIRA Institute for Biomedical Technology and Technical Medicine, Faculty of Science and Technology, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Macromol Biosci 13:573-83. 2013
    ..These resorbable and form-stable networks with tuneable properties may find application in a broad range of biomedical applications...
  91. ncbi Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys
    K Fujita
    Pharmacokinetic Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, Shizuoka, Japan
    Xenobiotica 38:511-26. 2008
    ..These species differences in urinary excretion of KW-4490 and its acylglucuronide metabolites are most likely due to substrate specificity of active transporters in rat and monkey kidney...
  92. ncbi Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Stroke 43:1463-9. 2012
    ..CONSCIOUS-3 assessed whether clazosentan reduced vasospasm-related morbidity and all-cause mortality postaSAH secured by endovascular coiling...
  93. ncbi Gel formation driven by tunable hydrophobic domain: design of acrylamide macromonomer with oligo hydrophobic segment
    Kyohei Nitta
    Department of Chemistry of Functional Molecules, Faculty of Science and Engineering, Konan University, Higashinada ku, Kobe, Japan
    Biomacromolecules 13:1002-9. 2012
    ..Therefore, these amphiphilic graft copolymers containing a PTMC segment are excellent candidates for use as hydrophobic drug delivery carriers...
  94. ncbi Series spiral advancement flap: an alternative to the ellipse
    P J Weber
    Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA
    Dermatol Surg 27:64-6. 2001
    ..Proper patient and lesion selection aids in obtaining an acceptable outcome. CONCLUSION: The series spiral advancement flap has the potential to become a useful and common surgical technique...
  95. ncbi Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice
    Y Ago
    Laboratory of Medicinal Pharmacology, and Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Neurochem 83:353-9. 2002
    ..The present findings suggest that isolation rearing enhances the activity of cortical dopaminergic neurons and reduces selectively the 5-HT1A receptor-mediated release of DA in the cortex...
  96. ncbi Self-assembly and host-guest chemistry of a 3.5-nm coordination nanotube
    Takumi Yamaguchi
    Department of Applied Chemistry, School of Engineering, The University of Tokyo, Japan
    Chem Asian J 2:468-76. 2007
    ..Tetrathiafulvalene (TTF)-terminated linear guests were directly oxidized to TTF2+ in the tube, but reduced stepwise via TTF+ outside the tube...
  97. ncbi Lightweight partially absorbable monofilament mesh (polypropylene/poliglecaprone 25) for TAPP inguinal hernia repair: initial experience
    Ferdinando Agresta
    Department of General Surgery, Ospedale Civile, Via Forlanini, 71, 31029 Vittorio Veneto, Italy
    Surg Laparosc Endosc Percutan Tech 17:91-4. 2007
    ....
  98. ncbi Adhesion and growth of human Schwann cells on trimethylene carbonate (co)polymers
    Ana Paula Pêgo
    Institute for Biomedical Technology BMTI and Department of Polymer Chemistry and Biomaterials, Faculty of Chemical Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    J Biomed Mater Res A 67:876-85. 2003
    ..The results indicate that all tested materials support the adhesion and proliferation of HSCs and can in principle be used for the preparation of flexible and slowly degrading nerve guides...
  99. pmc Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models
    Thomas A Natoli
    Department of Cell Biology, Genzyme Corporation, Framingham, Massachusetts, USA
    Nat Med 16:788-92. 2010
    ..Taken together, our data suggest that inhibition of GlcCer synthesis represents a new and effective treatment option for PKD...
  100. ncbi Distribution of 1,4-dioxane and N, N-dimethylformamide in river water from Niigata, Japan
    K Kawata
    Niigata Prefectural Institute of Public Health and Environment Sciences, 314 1 Sowa, Niigata 950 2144, Japan
    Bull Environ Contam Toxicol 70:876-82. 2003
  101. ncbi Clazosentan: prevention of cerebral vasospasm and the potential to overcome infarction
    Juergen Beck
    Department of Neurosurgery, Inselspital, University of Bern, Bern, Switzerland
    Acta Neurochir Suppl 110:147-50. 2011
    ..Two additional large-scale studies (CONSCIOUS-2 and CONSCIOUS-3) are now underway to further investigate the potential of clazosentan to improve long-term clinical outcome...

Research Grants21

  1. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  2. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..
  3. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    ..abstract_text> ..
  4. Inhibitors of Hedgehog Signaling For Brain Cancer Chemotherapy
    JEFFREY D contact WINKLER; Fiscal Year: 2010
    ..The studies outlined herein therefore hold the promise of developing important new tools in cancer biology and new drug candidates for the treatment of brain cancers. ..
  5. Pittsburgh Molecular Libraries Screening Center(RMI)
    JOHN LAZO; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  6. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  7. Chemical Complementation Assay for MKP-1 (RMI)
    JOHN LAZO; Fiscal Year: 2005
    ..This proposal will provide sufficient reagents, including cells and DMA transfection vectors, to permit the high throughput screening of 100,000 compounds. ..
  8. In Vitro High Throughput Screening Assay for MKP-1(RMI)
    JOHN LAZO; Fiscal Year: 2005
    ..No potent or selective small molecule inhibitors of this protein phosphatase are known. This proposal will provide sufficient reagents to permit a high throughput screening of 100,000 compounds. ..
  9. In Vitro High Throughput Screening Assay for MKP-3(RMI)
    JOHN LAZO; Fiscal Year: 2005
    ..Nonetheless, no potent or selective small molecule inhibitors of this protein phosphatase have been identified. This proposal will provide sufficient reagents to permit a high throughput screening of 100,000 compounds ..
  10. Chemical Complementation Assay for MKP-3 (RMI)
    JOHN LAZO; Fiscal Year: 2005
    ..This proposal will provide sufficient reagents, including cells and DMA transfection vectors, to permit the high throughput screening of 100,000 compounds. ..
  11. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  12. BIOCHEMICAL REGULATORS OF BLEOMYCIN INDUCED TUMORS
    JOHN LAZO; Fiscal Year: 2001
    ..The Specific Aims are to: 1) develop cells and mice deficient in BH, 2) develop cells and mice that overexpress BH, 3) isolate and characterize potential proteins that interact with BH and, 4) analyze the regulation of BH expression. ..
  13. Bleomycin Hydrolase and Alzheimer's Disease
    JOHN LAZO; Fiscal Year: 2004
    ..These studies should provide new mechanistic information concerning the pathogenesis of AD as well as reagents for future therapeutic studies. ..
  14. THIOREDOXIN REDUCTASES AND CANCER
    Garth Powis; Fiscal Year: 2001
    ....
  15. Small-Molecule Probes for Conditional Modulation of the Synapse Proteome
    Stephen Haggarty; Fiscal Year: 2007
    ..In the future chemical biology in general, and chemical genetics in particular, will play an important role in catalyzing new discoveries and potentially insight into function of the nervous system. ..
  16. Survival Signals for Molecular Target Assessment
    Garth Powis; Fiscal Year: 2006
    ..The work will provide important insights into the way these new types of agents can be developed and how their clinical trial should be conducted. ..
  17. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003
    ..abstract_text> ..
  18. Clinically relevant large animal model of rotator cuff injury and repair
    Kathleen Derwin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. A role for intrinsic tendon cells in overuse injury
    Kathleen Derwin; Fiscal Year: 2005
    ..A role for intrinsic tendon cells in the pathogenesis of tendon overuse injury would be implied by a lower damage threshold in vital tendon. ..
  20. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..abstract_text> ..
  21. Novel Inhibitors of Akt Signaling in Pancreatic Cancer
    Garth Powis; Fiscal Year: 2009
    ..The PtdIns-3-kinase/Akt signaling pathway is upregulated in many pancreatic cancers making it an ideal target for drugs to treat the disease. ..