alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid

Summary

Summary: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

Top Publications

  1. ncbi Testosterone amplifies excitotoxic damage of cultured oligodendrocytes
    A Caruso
    Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Rome, Italy
    J Neurochem 88:1179-85. 2004
  2. ncbi Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
  3. ncbi Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 97:2949-57. 2007
  4. ncbi Miniature synaptic events maintain dendritic spines via AMPA receptor activation
    R A McKinney
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 2:44-9. 1999
  5. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
  6. pmc Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation
    Yuri V Pankratov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Biophys J 85:3375-87. 2003
  7. ncbi Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
  8. ncbi Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury
    Karolina Wosik
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    Brain 127:2636-48. 2004
  9. ncbi Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4
    E J Fletcher
    Allelix Biopharmaceuticals Inc, Mississauga, ON, Canada
    Receptors Channels 3:21-31. 1995
  10. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002

Research Grants

  1. Regulation of D-serine Neuromodulation by PKCalpha and PICK1
    ASIF MUSTAFA; Fiscal Year: 2007
  2. Excitability and Plasticity in Epileptic Brain
    Jeffrey Noebels; Fiscal Year: 2006
  3. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2010
  4. Retinal Remodeling
    Robert Marc; Fiscal Year: 2009
  5. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2009
  6. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2007
  7. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2005
  8. Retinal Remodeling
    Robert Marc; Fiscal Year: 2007
  9. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2011
  10. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2000

Detail Information

Publications187 found, 100 shown here

  1. ncbi Testosterone amplifies excitotoxic damage of cultured oligodendrocytes
    A Caruso
    Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Rome, Italy
    J Neurochem 88:1179-85. 2004
    ..We conclude that testosterone amplifies excitotoxic damage of oligodendrocytes acting at an early step of the death cascade triggered by AMPA/kainate receptors...
  2. ncbi Encoding and decoding of dendritic excitation during active states in pyramidal neurons
    Stephen R Williams
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 25:5894-902. 2005
    ..During active states, therefore, distal excitatory synaptic inputs decisively control the excitatory synaptic output of layer 5 neocortical pyramidal neurons and so powerfully influence network activity in the neocortex...
  3. ncbi Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 97:2949-57. 2007
    ..This suggests that in vivo visual stimulation increases synapses that have a low Pr and that have properties consistent with immature synapses...
  4. ncbi Miniature synaptic events maintain dendritic spines via AMPA receptor activation
    R A McKinney
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 2:44-9. 1999
    ..Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines...
  5. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
    ..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
  6. pmc Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation
    Yuri V Pankratov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Biophys J 85:3375-87. 2003
    ....
  7. ncbi Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
    ..Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses...
  8. ncbi Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury
    Karolina Wosik
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    Brain 127:2636-48. 2004
    ..The apparent lack of glutamate receptor expression on human OLs and their resistance to AMPA/kainate toxicity should be considered when postulating mechanisms of tissue injury in multiple sclerosis...
  9. ncbi Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4
    E J Fletcher
    Allelix Biopharmaceuticals Inc, Mississauga, ON, Canada
    Receptors Channels 3:21-31. 1995
    ..This is the first report of the cloning of hGluR4 receptor and its stable expression in a human cell line...
  10. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002
    ..Overall, our data suggest that glutamatergic synaptic transmission mediated by AMPA/KA GluRs play an important role throughout the SCN synaptic circuitry...
  11. ncbi The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons
    M D Kopp
    , Frankfurt, Germany
    J Neurochem 79:161-71. 2001
    ..The observed PACAPergic effects provide a broad range of interactions that allow a fine-tuning of the endogenous clock by the integration of 'light' and 'darkness' information on the level of single SCN neurons...
  12. ncbi Glutamatergic and serotonergic mechanisms in the dorsal facial area for common carotid artery blood flow control in the cat
    Chi Li Gong
    Department of Physiology, School of Medicine, China Medical College, Taichung, Taiwan, ROC
    Auton Neurosci 101:85-90. 2002
    ..Such response may be suppressed by 5-HT2 action...
  13. ncbi Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors
    Isaac Shemer
    Department of Neuroscience, Retzius väg 8 A3 417, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 23:2035-47. 2006
    ..We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors...
  14. ncbi NMDA and AMPA/kainate glutamatergic agonists increase the extracellular concentrations of GABA in the prefrontal cortex of the freely moving rat: modulation by endogenous dopamine
    Alberto Del Arco
    Department of Physiology, Faculty of Medicine, University Complutense, Ciudad Universitaria s n, 28040 Madrid, Spain
    Brain Res Bull 57:623-30. 2002
    ....
  15. ncbi Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice
    Vinicius M Gadotti
    Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040 900, SC, Brazil
    Brain Res 1093:116-22. 2006
    ....
  16. ncbi Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 86:792-804. 2003
    ..Taken together, these data make important contributions to the elucidation of the downstream pathways activated in AMPA receptor-mediated excitotoxicity in cultured rat hippocampal neurones...
  17. pmc Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia
    Kuei Yuan Tseng
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    Biol Psychiatry 62:730-8. 2007
    ....
  18. ncbi Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons
    Tomofusa Yamauchi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neurosci Lett 347:155-8. 2003
    ..These results suggest that dopamine inhibits glutamate induced-NOS activation via D1 receptor, resulting in the protection of retinal neurons...
  19. ncbi RNA synthesis-dependent potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated toxicity by antihistamine terfenadine in cultured rat cerebellar neurons
    Ramon Diaz-Trelles
    Department of Biochemistry and Molecular Biology, University of Oviedo, Campus El Cristo, 33071 Oviedo, Spain
    Neurosci Lett 345:136-40. 2003
    ..Terfenadine reduced neuronal steady-state concentrations of [Ca2+](i) by approximately 75%. Our results suggest a role for histamine H1 receptors and intracellular calcium in the modulation of the excitotoxic response via AMPA receptors...
  20. pmc Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons
    Hui Fang Li
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, U S A
    Br J Pharmacol 139:73-80. 2003
    ..Both tyrosine kinase and PKC, but not PKA, appear to be essential for EtOH withdrawal hyper-responsiveness mediated by postsynaptic NMDA receptors in spinal cord motor neurons...
  21. pmc Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina
    Svein Harald Mørkve
    University of Bergen, Department of Anatomy and Cell Biology, Bergen, Norway
    J Physiol 542:147-65. 2002
    ..Thus, our results indicate expression of high-affinity, voltage-sensitive AMPA receptors with significant Ca2+ permeability and relatively large single-channel chord conductances in AII amacrine cells...
  22. ncbi AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure
    Shu Huei Hsiao
    Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine MS 1114, College Station, TX 77843 1114, USA
    Brain Res Dev Brain Res 142:89-99. 2003
    ..Repeating this inhibition during early postnatal binge-like intoxication can augment normal development of AMPAR function...
  23. ncbi Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex
    Neil J Bannister
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:5259-71. 2005
    ..Thus, the developmental switch in transmission will dramatically alter information transfer at thalamocortical inputs to layer IV...
  24. ncbi Dopamine release in the prefrontal cortex during stress is reduced by the local activation of glutamate receptors
    A Del Arco
    Department of Physiology, Faculty of Medicine, University Complutense, Madrid, Spain
    Brain Res Bull 56:125-30. 2001
    ..These results show that the local activation of prefrontal glutamatergic ionotropic receptors reduces the stress-induced dopamine release in the prefrontal cortex of the rat...
  25. pmc Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 99:549-60. 2006
    ..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation...
  26. ncbi Long-term potentiation of the AMPA and NMDA components of minimal postsynaptic currents in rat hippocampal field Ca1
    I T Bayazitov
    Institute of the Brain, Russian Academy of Medical Sciences, Moscow
    Neurosci Behav Physiol 32:533-40. 2002
    ....
  27. ncbi Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission
    Emiliano M Rial Verde
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:461-74. 2006
    ..Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength...
  28. ncbi Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents
    Matthew T Colonnese
    Department of Biology, Department of Brain and Cognitive Science, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Neurophysiol 89:57-68. 2003
    ..Together the present data show that NR function is necessary for subsequent NR current regulation in vivo, but it is not essential for the developmental expression of normal AMPAR currents...
  29. ncbi Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect
    Wan Chen Lo
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, ROC
    Eur J Pharmacol 454:39-45. 2002
    ..They also suggested that CO and excitatory amino acids may interact in the nucleus tractus solitarii of rats...
  30. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
    ....
  31. ncbi Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues
    Jon Valgeirsson
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Bioorg Med Chem 11:4341-9. 2003
    ..Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site...
  32. ncbi The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid
    Rasmus P Clausen
    Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Eur J Pharmacol 499:35-44. 2004
    ....
  33. ncbi Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices
    Shuqiu Zheng
    Department of Anesthesiology, University of Virginia Health System, One Hospital Drive, P O Box 800710, Charlottesville, VA 22908 0710, USA
    Brain Res 1054:143-51. 2005
    ..Thus, isoflurane preconditioning reduced glutamate receptor overstimulation-induced neuronal injury/death. This neuroprotection may be PKC- and NOS-dependent...
  34. ncbi Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat
    Claudia Iserhot
    Johannes Mueller Institute of Physiology, Dept of Neurophysiology, Faculty of Medicine Charite, Humboldt University, Tucholskystr 2, 10117 Berlin, Germany
    Brain Res 1027:151-60. 2004
    ..The present data suggest that glutamate transporters and group I/II mGluRs regulate excitatory synaptic transmission in the mEC. Presynaptic mGluRs may limit excessive glutamate accumulation if uptake becomes compromised...
  35. ncbi Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica)
    Charlotte A Cornil
    Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, University of Liege, 17 Place Delcour Bat L1, B 4020 Liege, Belgium
    Brain Res 1029:224-40. 2004
    ....
  36. ncbi BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury
    Sandra M Garraway
    Department of Neurobiology and Behavior, 550 Life Sciences Bldg, State University of New York, Stony Brook, New York 11794 5230, USA
    J Neurophysiol 94:1798-804. 2005
    ..It seems more likely that diminished trkB expression and enhanced expression of truncated trkB receptors in the contused cord play a significant role in determining the reduced effect of BDNF under these conditions...
  37. ncbi Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons
    Michel Eybalin
    INSERM U583, Institut des Neurosciences, Hopital St Eloi, 80, avenue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5, France
    Eur J Neurosci 20:2981-9. 2004
    ..The postsynaptic expression of GluR2 subunits may be continuously regulated by the presynaptic activity allowing for variations in the Ca2+ permeability and physiological properties of the receptor...
  38. ncbi Depressor responses to L-proline microinjected into the rat ventrolateral medulla are mediated by ionotropic excitatory amino acid receptors
    Yumi Takemoto
    Department of Neurophysiology, Division of Integrated Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Auton Neurosci 120:108-12. 2005
    ..The results indicate that the depressor response to L-proline in the CVLM includes mechanisms of ionotropic excitatory amino acid receptors...
  39. pmc D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons
    Xiang Qun Gong
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Br J Pharmacol 145:449-59. 2005
    ..The prevalence of D-aspartate in the brain suggests a possible role of D-aspartate in modulating AMPAR-mediated fast excitatory synaptic transmission...
  40. ncbi Long-term depression at olfactory nerve synapses
    Hiroki Mutoh
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 25:4252-9. 2005
    ..LTD at the ON--> MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb...
  41. ncbi Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 20:1665-73. 2004
    ....
  42. ncbi Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization...
  43. ncbi Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection
    Lavina J Faleiro
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 29:2115-25. 2004
    ..We conclude that amphetamine induces rapid changes in synaptic AMPAR/NMDAR ratios, suggesting that potentiation of glutamatergic synapses is a relatively early event in the series of neuroadaptations in response to drugs of abuse...
  44. ncbi Metabotropic glutamate receptors modulate the NMDA- and AMPA-induced gene expression in neocortical interneurons
    Kerstin Lindemeyer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University, Freiburg, Germany
    Cereb Cortex 16:1662-77. 2006
    ..Our results suggest that mGluRIs regulate the glutamate-induced gene expression in neocortical interneurons in a physiologically relevant manner...
  45. ncbi Chronic nicotine causes functional upregulation of ionotropic glutamate receptors mediating hippocampal noradrenaline and striatal dopamine release
    Francesca Risso
    Sezione di Farmacologia e Tossicologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Viale Cembrano 4, Genoa 16148, Italy
    Neurochem Int 44:293-301. 2004
    ..Thus, chronic exposure to nicotine enhances the function of ionotropic glutamate receptors mediating noradrenaline release in the hippocampus and dopamine release in the striatum...
  46. ncbi Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
    Paulo Roberto Louzada
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brasil
    FASEB J 18:511-8. 2004
    ..GABAergic transmission may represent a promising target for the treatment of AD and other neurological disorders in which excitotoxicity plays a relevant role...
  47. ncbi AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin
    Su Jin Kim
    Department of Molecular Cell Biology, Sungkyunkwan Univresity School of Medicine, Suwon 440 746, Korea
    Exp Mol Med 36:98-102. 2004
    ..These results suggest that glutamate-induced phosphorylation of moesin may be mediated through the AMPA receptor/RhoA/Rho kinase pathway...
  48. ncbi A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
    Alanna J Watt
    Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Neurosci 7:518-24. 2004
    ..This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing...
  49. ncbi Glutamate receptor subtypes in human retinal horizontal cells
    Wen Shen
    Department of Physiology and Biophysics, University at Buffalo, Buffalo, NY 14214, USA
    Vis Neurosci 21:89-95. 2004
    ..The diversity of glutamate receptors in human horizontal cells suggests that synaptic input to these neurons may be multiplexed through both kainate and AMPA channels...
  50. ncbi AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo
    Juan Carlos Corona
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    J Neurochem 89:988-97. 2004
    ....
  51. ncbi TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
    Nathalie Rouach
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 8:1525-33. 2005
    ....
  52. ncbi Expression of functional kainate and AMPA receptors in developing lateral superior olive neurons of the rat
    Harald Vitten
    Animal Physiology Group, Department of Biology, University of Kaiserslautern, Germany
    J Neurobiol 59:272-88. 2004
    ..Electrical stimulation of ipsilateral input fibers in the presence of KAR antagonists (NS-102 and GAMS), modulators (WGA), or GYKI 52466 revealed the presence of synaptic KARs in LSO neurons...
  53. ncbi Rap2-JNK removes synaptic AMPA receptors during depotentiation
    Yinghua Zhu
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neuron 46:905-16. 2005
    ....
  54. ncbi Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes
    Elena Alberdi
    Departamento de Neurociencias, Universidad del Pais Vasco, Leioa, Vizcaya, Spain
    Neurobiol Dis 9:234-43. 2002
    ....
  55. ncbi Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia
    Martine Hamann
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Eur J Neurosci 15:308-14. 2002
    ..These data are consistent with glutamate release being by reversal of neuronal transporters, and with uptake into glia being compromised by the ischaemia-evoked fall in the level of ATP needed to convert glutamate into glutamine...
  56. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ....
  57. ncbi Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons
    R Griffiths
    Neurochemistry Group, School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
    J Neurosci Res 48:533-42. 1997
    ....
  58. ncbi Long-term potentiation of silent synapses in substantia gelatinosa neurons
    Sung Jun Jung
    Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul 110 799, South Korea
    Neuroreport 16:961-5. 2005
    ....
  59. ncbi Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons
    C Lu
    Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Neurol 170:180-5. 2001
    ..Our data also identify a mechanism that might explain clinical effects of DMSO on both peripheral and CNS neurons and suggest a potential use for DMSO in the treatment of excitotoxic neurodegenerative conditions...
  60. ncbi Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator
    P J Baumbarger
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 298:86-102. 2001
    ..The therapeutic implications of AMPA receptor potentiators are discussed...
  61. doi Serotoninergic modulation of sensory transmission to brainstem reticulospinal cells
    Myriam Antri
    Groupe de Recherche sur le Système Nerveux Central, Departement de Physiologie, Universite de Montreal, Montreal, QC, H3C 3J7, Canada
    Eur J Neurosci 28:655-67. 2008
    ..Our results indicate that 5-HT modulates sensory transmission to lamprey brainstem RS cells...
  62. ncbi Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase
    G Fuller
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res Mol Brain Res 89:126-32. 2001
    ..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK...
  63. ncbi Expression and regulation of Na pump isoforms in cultured cerebellar granule cells
    T M Soga
    Department of Biochemistry I, Yokohama City University School of Medicine, Yokohama, Japan
    Neuroreport 12:829-32. 2001
    ..The glutamate effects were mainly mediated by non-NMDA receptors. These results suggest that alpha1 isoform and alpha3/alpha2 isoforms are functionally important under basal conditions and after neuronal excitation, respectively...
  64. doi Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
    Eur J Pharmacol 589:37-44. 2008
    ..Activation of both AMPA and NMDA receptors regulates the maturation of osteoblasts. NMDA but not AMPA affects receptor for activation of NF-kappaB ligand (RANKL)-induced osteoclastogenesis...
  65. ncbi Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures
    D Comoletti
    Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy
    J Neurol Sci 192:61-9. 2001
    ....
  66. doi Presynaptic modulation by somatostatin in the neostriatum
    Violeta Gisselle Lopez-Huerta
    Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, PO Box 70 253, Mexico City, DF, 04510, Mexico
    Neurochem Res 33:1452-8. 2008
    ..In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts...
  67. ncbi Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones
    Wei Min Dai
    Department of Physiology, University of Aarhus, Ole Worms Alle 160, DK 8000 Aarhus C, Denmark
    Brain Res 926:94-107. 2002
    ..The most likely expression patterns of functional KA receptors is GluR6/KA2 for cortical neurones and GluR5/KA2 for spinal cord neurones...
  68. ncbi Ca2+ entry via AMPA-type glutamate receptors triggers Ca2+-induced Ca2+ release from ryanodine receptors in rat spiral ganglion neurons
    Rachel T Morton-Jones
    Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand
    Cell Calcium 43:356-66. 2008
    ..These data demonstrate functional coupling between somatic AMPA-type glutamate receptors and intracellular Ca(2+) stores via RyR-dependent CICR in primary auditory neurons...
  69. ncbi N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx
    M Urushitani
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyoku, Kyoto, Japan
    J Neurosci Res 63:377-87. 2001
    ..These data indicate that acute excitotoxicity in spinal neurons is mediated by mitochondrial Ca(2+) overload and ROS generation through the activation of NMDA receptors. This mechanism is different from that of chronic GNT...
  70. ncbi Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with mu-opioid agonists
    J A Echo
    Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
    Brain Res 921:86-97. 2001
    ..These data indicate the presence of important interactions between excitatory amino acid receptors and mu-opioid receptors in the nucleus accumbens shell in mediating feeding responses in nondeprived, ad libitum-fed rats...
  71. pmc Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus
    C H Davies
    Department of Pharmacology, University of Edinburgh, UK
    J Physiol 496:451-70. 1996
    ..regulation of AMPA and NMDA receptor-mediated EPSPs during various patterns of synaptic activation caused by the dynamic changes in GABA-mediated synaptic inhibition, which are orchestrated by GABAA autoreceptors in a frequency-dependent..
  72. ncbi Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors
    A Gorman
    Division of Cell and Molecular Biology, School of Biological and Medical Sciences, University of Saint Andrews, Fife, Scotland, U K
    Neuroscience 59:299-308. 1994
    ..abstract truncated at 400 words)..
  73. pmc Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro
    R E Brown
    Department of Neurophysiology, Institute for Neurobiology, Magdeburg, Germany
    J Physiol 496:175-84. 1996
    ..The mechanism by which histamine depresses transmission is independent of that used by class III metabotropic glutamate receptors...
  74. ncbi Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice
    S Gylterud Owe
    Department of Anatomy and Centre for Molecular Biology and Neuroscience CMBN, University of Oslo, P O Box 1105 Blindern, N0317 Oslo, Norway
    Neuroscience 136:769-77. 2005
    ....
  75. ncbi BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
    M J Leach
    Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, England, UK
    Stroke 24:1063-7. 1993
    ..Therefore, compounds that block the release of glutamate may be useful as cerebroprotective agents. The purpose of this study was to evaluate the cerebroprotective properties of a glutamate release inhibitor, BW619C89...
  76. ncbi Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro
    R D Traub
    Department of Pharmacology, Division of Neuroscience, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Neurophysiol 85:1246-56. 2001
    ..We conclude that in 4-AP, axonal gap junctions could, at least in principle, account in part for both the large IPSPs, and for the antidromic activity in pyramidal neurons...
  77. ncbi Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes
    B E Akinshola
    Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
    Brain Res Mol Brain Res 93:8-17. 2001
    ....
  78. ncbi Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists
    J N Sengupta
    Division of Gastroenterology and Hepatology, MaccFund Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 125:711-23. 2004
    ....
  79. doi Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in mice
    Cristina Setim Freitas
    Department of Pharmacology, Sector of Biological Sciences, Federal University of Parana, Curitiba, PR, Brazil
    Basic Clin Pharmacol Toxicol 104:285-92. 2009
    ..Moreover, the antinociceptive action demonstrated in the present study supports the ethnomedical uses of this plant...
  80. ncbi Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas
    C D Weaver
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Mol Pharmacol 54:639-46. 1998
    ....
  81. doi Pharmacological characterization of harmaline-induced tremor activity in mice
    Neil E Paterson
    Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Eur J Pharmacol 616:73-80. 2009
    ..Further, these data provide additional evidence for the roles of ionotropic glutamate, GABA(A) and dopamine D(2)/D(3) receptors in the neurobiology of harmaline-induced tremor...
  82. doi Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal horn
    Rainer Haseneder
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Anesthesiology 111:1297-307. 2009
    ..In the current study, the authors examined the effects of xenon on synaptic transmission in the prefrontal cortex and the spinal cord dorsal horn (substantia gelatinosa)...
  83. pmc Species-dependent functional properties of non-NMDA receptors expressed in Xenopus laevis oocytes injected with mammalian and avian brain mRNA
    D Bowie
    Department of Pharmacology, School of Pharmacy, University of London
    Br J Pharmacol 111:803-10. 1994
    ..Our observations may reflect further heterogeneity of non-NMDA receptors in the central nervous system of different vertebrate species...
  84. ncbi Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea
    R Sakai
    School of Fisheries Sciences, Kitasato University, Kesen gun Sanriku cho, Iwate, Japan
    J Pharmacol Exp Ther 296:650-8. 2001
    ..This novel excitatory amino acid may prove useful for evaluating the physiological and pathological roles of non-NMDA receptors, especially KA receptors, in the central nervous system...
  85. ncbi Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
    D T Joo
    Department of Anesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 94:478-88. 2001
    ..To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined...
  86. ncbi Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats
    Hiroshi Yamashita
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
    Naunyn Schmiedebergs Arch Pharmacol 370:99-105. 2004
    ..YM928 is expected to have beneficial effects against human complex partial seizure with secondary generalization or temporal lobe epilepsy...
  87. ncbi Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland
    J Pharmacol Exp Ther 299:1161-8. 2001
    ..Both processes could provide the biochemical basis of the observed ifosfamide-associated encephalopathy...
  88. doi Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels
    Liping Huang
    Department of Pharmacology and Toxicology, University of Otago, PO Box 913, Dunedin, New Zealand
    J Pharm Pharmacol 60:1515-22. 2008
    ..These data suggest that components common to the two oils are worthy of focus to identify the actives underlying the neuronal depressant and anti-agitation activities reported...
  89. pmc Age-related functional changes of the glutamate receptor channels in rat Meynert neurones
    N Akaike
    Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Physiol 504:665-81. 1997
    ..The KA-induced IK(Ca), which developed with ageing, may thus function as one of the negative feedback systems, and thereby prevent excess cell excitation and neural damage, especially in adult rats...
  90. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
    ..The large gain in potency conferred by alkyl substitution suggests that the 5' substituent is in intimate contact with the receptor, with the size of the substituent determining the way in which receptor kinetics is changed...
  91. ncbi Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels
    J O Malva
    Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Portugal
    Neurochem Int 32:7-16. 1998
    ....
  92. ncbi Glutamatergic synaptic transmission participates in generating the hippocampal EEG
    L Stan Leung
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hippocampus 14:510-25. 2004
    ..Excitatory glutamatergic synaptic currents, activated by afferents from the entorhinal cortex and CA3, are suggested to participate in hippocampal EEG activities...
  93. doi Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling
    Olivia F O'Leary
    Neuroscience Centre, University of Helsinki, Finland
    Psychoneuroendocrinology 34:367-81. 2009
    ..Moreover, these effects were only observed in ovariectomized animals, thus suggesting that fluoxetine-induced increases in synaptic protein levels might only occur or become detectable when hippocampal synaptic connectivity is perturbed...
  94. ncbi [Update on anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Nerve 62:331-8. 2010
    ..In a recent case, a microscopic teratoma was detected on autopsy; therefore exploratory laparotomy may be considered in severe refractory cases...
  95. ncbi Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats
    Hiroshi Yamashita
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    J Pharmacol Exp Ther 308:127-33. 2004
    ..These results indicate that YM928 is a broad-spectrum anticonvulsant that would prove useful for the treatment of generalized seizure in human epileptic patients...
  96. ncbi Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Neurosci Lett 421:87-90. 2007
    ..p. administration), deserves more attention as a potential antiepileptic drug for patients in status epilepticus...
  97. ncbi Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats
    Pia Bäckström
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Psychopharmacology (Berl) 192:571-80. 2007
    ..Nucleus accumbens glutamate transmission has been implicated in drug-seeking behavior, but the involvement of glutamate receptor subtypes in drug seeking maintained by drug-associated cues has not been fully investigated...
  98. ncbi Modulatory effects of dextran sulfate and fucoidan on binding and channel properties of AMPA receptors isolated from rat brain
    Vishnu Suppiramaniam
    Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Alabama 36849, USA
    Synapse 60:456-64. 2006
    ..These findings suggest that GAG components of proteoglycans can interact with and alter the binding affinity of AMPA receptors and modulate their functional properties...
  99. pmc Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
    J Harvey
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 109:1085-90. 1993
    ..It involves a Ca2+-sensitive process and is negatively regulated by protein kinase C...
  100. ncbi The cerebral metabolic effects of manipulating glutamatergic systems within the basal forebrain in conscious rats
    S E Browne
    Wellcome Surgical Institute, University of Glasgow, Scotland
    Eur J Neurosci 10:649-63. 1998
    ..Results support a dissociation between the functional sequelae of NMDA and non-NMDA receptor-mediated events in the basal forebrain, and long-term compensatory functional adaptation following cortical denervation...
  101. ncbi Large variability in synaptic N-methyl-D-aspartate receptor density on interneurons and a comparison with pyramidal-cell spines in the rat hippocampus
    G Nyiri
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, PO Box 37, H 1450, Hungary
    Neuroscience 119:347-63. 2003
    ..Consequently, fast glutamatergic activation of interneurons is expected to show cell type-specific time course and state-dependent dynamics...

Research Grants122 found, 100 shown here

  1. Regulation of D-serine Neuromodulation by PKCalpha and PICK1
    ASIF MUSTAFA; Fiscal Year: 2007
    ..All this will primarily be accomplished by a combination of radiolabeling experiments, the use of pharmacological agents, mass spectrometry analysis, site-directed mutagenesis and the DsdA-LDH assay. ..
  2. Excitability and Plasticity in Epileptic Brain
    Jeffrey Noebels; Fiscal Year: 2006
    ....
  3. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2010
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  4. Retinal Remodeling
    Robert Marc; Fiscal Year: 2009
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  5. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2009
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  6. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2007
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  7. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2005
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..
  8. Retinal Remodeling
    Robert Marc; Fiscal Year: 2007
    ..Restoring retinas must eventually involve guiding remodeled and implanted cells to assume functional architectures. Failing that, remodeling must be prevented or rescues instituted prior to remodeling onset. ..
  9. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2011
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  10. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2000
    ..This catalogue will assign not only a primary neurotransmitter but also a comprehensive signature to a specific morphology and synaptology. ..
  11. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert E Marc; Fiscal Year: 2010
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  12. Mechanisms of Peripheral Analgesia: Group II mGluRs
    Susan Carlton; Fiscal Year: 2007
    ..Enhancing activity of peripheral inhibitory Group II mGluRs could provide a non-opioid therapy for pain, avoiding CNS and PNS side effects inherent in opioid treatment. ..
  13. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2007
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  14. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2007
    ....
  15. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..We will assess the behavioral, physiological and anatomical outcomes of NISAs treatment, evaluating their potential to yield highly desirable analgesics which could greatly reduce the current reliance on opioid therapies. ..
  16. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  17. Peripheral Sensitization Following Spinal Cord Injury
    Susan M Carlton; Fiscal Year: 2010
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  18. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2010
    ....
  19. Peripheral Sensitization Following Spinal Cord Injury
    Susan Carlton; Fiscal Year: 2009
    ..In this proposal we will elucidate mechanisms that heretofore have been unknown contributors to central neuropathic pain. ..
  20. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  21. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. ..
  22. NEURAL MECHANISMS OF VOCAL LEARNING
    SARAH BOTTJER; Fiscal Year: 2009
    ..abstract_text> ..
  23. Detailed models of network bursts and oscillations
    ROGER TRAUB; Fiscal Year: 2007
    ..A successful model will generate specific and testable predictions useful to experimental collaborators, who have worked closely on this project in the past and continue to do so. ..
  24. Detailed models of network bursts and oscillations
    Roger D Traub; Fiscal Year: 2010
    ..A successful model will generate specific and testable predictions useful to experimental collaborators, who have worked closely on this project in the past and continue to do so. ..
  25. Cellular Plasticity Following Repeated Amphetamine
    Christopher Nelson; Fiscal Year: 2007
    ....
  26. Alterations in chemoafferent integration induced by chronic intermittent hypoxia
    STEVEN MIFFLIN; Fiscal Year: 2007
    ..These factors mediate much of the pathology associated with sleep apnea including hypertension, increased risk of adverse cardiovascular events and insulin resistance. ..
  27. Detailed models of network bursts and oscillations
    ROGER TRAUB; Fiscal Year: 2009
    ..A successful model will generate specific and testable predictions useful to experimental collaborators, who have worked closely on this project in the past and continue to do so. ..
  28. Neurophysiology of breathing behavior in mammals studied in neonatal mice in vitr
    Christopher A Del Negro; Fiscal Year: 2010
    ..The new knowledge obtained will serve as a foundation for the treatment and prevention of respiratory disorders with a central neural etiology, and elucidate circuit-level properties that underlie rhythmic motor behaviors in general. ..
  29. Cellular Mechanisms Underlying the Long-term Potentiation of GABA Release
    SIQIONG LIU; Fiscal Year: 2007
    ....
  30. DEVELOPMENTAL CHANGES IN NEURAL CIRCUITS FOR A BEHAVIOR
    SARAH BOTTJER; Fiscal Year: 1999
    ..We will begin to explore this remarkable result by investigating the role of sex hormones on cell division in the telencephalon. ..
  31. Neurotrophin Protection of Hypoxic Ischemic Brain Injury
    Mir Ahamed Hossain; Fiscal Year: 2010
    ..Our findings will contribute towards the development of preventive or therapeutic interventions for this major human health problem in the United States and in the world. ..
  32. NEURAL MECHANISMS OF VOCAL LEARNING
    SARAH BOTTJER; Fiscal Year: 2004
    ..The results of these experiments will also bear importantly on hypotheses of vocal learning in humans, and may have immediate application to problems of speech perception and production. ..
  33. NEURAL MECHANISMS OF VOCAL LEARNING
    SARAH BOTTJER; Fiscal Year: 1999
    ....
  34. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
    ..abstract_text> ..
  35. DEVELOPMENTAL CHANGES IN NEURAL CIRCUITS FOR A BEHAVIOR
    SARAH BOTTJER; Fiscal Year: 2003
    ....
  36. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  37. Genetic Dissection of Brain Reward Circuits
    LARRY ZWEIFEL; Fiscal Year: 2007
    ....