Genomes and Genes
alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid
Summary: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Publications232 found, 100 shown here
- The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neuronsM D Kopp
, Frankfurt, Germany
J Neurochem 79:161-71. 2001..The observed PACAPergic effects provide a broad range of interactions that allow a fine-tuning of the endogenous clock by the integration of 'light' and 'darkness' information on the level of single SCN neurons...
- Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injuryKarolina Wosik
Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
Brain 127:2636-48. 2004..The apparent lack of glutamate receptor expression on human OLs and their resistance to AMPA/kainate toxicity should be considered when postulating mechanisms of tissue injury in multiple sclerosis...
- Testosterone amplifies excitotoxic damage of cultured oligodendrocytesA Caruso
Department of Human Physiology and Pharmacology, University of Rome, La Sapienza, Rome, Italy
J Neurochem 88:1179-85. 2004..We conclude that testosterone amplifies excitotoxic damage of oligodendrocytes acting at an early step of the death cascade triggered by AMPA/kainate receptors...
- Miniature synaptic events maintain dendritic spines via AMPA receptor activationR A McKinney
Brain Research Institute, University of Zurich, Switzerland
Nat Neurosci 2:44-9. 1999..Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines...
- Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projectionCarlos D Aizenman
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
J Neurophysiol 97:2949-57. 2007..This suggests that in vivo visual stimulation increases synapses that have a low Pr and that have properties consistent with immature synapses...
- Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neuronsMark A Smith
Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
J Physiol 548:245-58. 2003..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
- Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturationYuri V Pankratov
Bogomoletz Institute of Physiology, Kiev, Ukraine
Biophys J 85:3375-87. 2003....
- Encoding and decoding of dendritic excitation during active states in pyramidal neuronsStephen R Williams
Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
J Neurosci 25:5894-902. 2005..During active states, therefore, distal excitatory synaptic inputs decisively control the excitatory synaptic output of layer 5 neocortical pyramidal neurons and so powerfully influence network activity in the neocortex...
- Maturation of a central glutamatergic synapseG Wu
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Science 274:972-6. 1996..Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses...
- Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptorsStephan Michel
Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
J Neurophysiol 88:817-28. 2002..Overall, our data suggest that glutamatergic synaptic transmission mediated by AMPA/KA GluRs play an important role throughout the SCN synaptic circuitry...
- Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4E J Fletcher
Allelix Biopharmaceuticals Inc, Mississauga, ON, Canada
Receptors Channels 3:21-31. 1995..This is the first report of the cloning of hGluR4 receptor and its stable expression in a human cell line...
- Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neuronesWei Min Dai
Department of Physiology, University of Aarhus, Ole Worms Alle 160, DK 8000 Aarhus C, Denmark
Brain Res 926:94-107. 2002..The most likely expression patterns of functional KA receptors is GluR6/KA2 for cortical neurones and GluR5/KA2 for spinal cord neurones...
- Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neuronsSang Hyoung Lee
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
Neuron 43:221-36. 2004..Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization...
- Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injectionLavina J Faleiro
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
Neuropsychopharmacology 29:2115-25. 2004..We conclude that amphetamine induces rapid changes in synaptic AMPAR/NMDAR ratios, suggesting that potentiation of glutamatergic synapses is a relatively early event in the series of neuroadaptations in response to drugs of abuse...
- Expression of functional kainate and AMPA receptors in developing lateral superior olive neurons of the ratHarald Vitten
Animal Physiology Group, Department of Biology, University of Kaiserslautern, Germany
J Neurobiol 59:272-88. 2004..Electrical stimulation of ipsilateral input fibers in the presence of KAR antagonists (NS-102 and GAMS), modulators (WGA), or GYKI 52466 revealed the presence of synaptic KARs in LSO neurons...
- Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with mu-opioid agonistsJ A Echo
Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
Brain Res 921:86-97. 2001..These data indicate the presence of important interactions between excitatory amino acid receptors and mu-opioid receptors in the nucleus accumbens shell in mediating feeding responses in nondeprived, ad libitum-fed rats...
- Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamusJ Martin Verkuyl
Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 20:1665-73. 2004....
- Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neuronsC Lu
Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Neurol 170:180-5. 2001..Our data also identify a mechanism that might explain clinical effects of DMSO on both peripheral and CNS neurons and suggest a potential use for DMSO in the treatment of excitotoxic neurodegenerative conditions...
- Long-term depression at olfactory nerve synapsesHiroki Mutoh
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 0198, Japan
J Neurosci 25:4252-9. 2005..LTD at the ON--> MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb...
- D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neuronsXiang Qun Gong
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
Br J Pharmacol 145:449-59. 2005..The prevalence of D-aspartate in the brain suggests a possible role of D-aspartate in modulating AMPAR-mediated fast excitatory synaptic transmission...
- Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neuronsMichel Eybalin
INSERM U583, Institut des Neurosciences, Hopital St Eloi, 80, avenue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5, France
Eur J Neurosci 20:2981-9. 2004..The postsynaptic expression of GluR2 subunits may be continuously regulated by the presynaptic activity allowing for variations in the Ca2+ permeability and physiological properties of the receptor...
- Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica)Charlotte A Cornil
Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, University of Liege, 17 Place Delcour Bat L1, B 4020 Liege, Belgium
Brain Res 1029:224-40. 2004....
- Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the ratClaudia Iserhot
Johannes Mueller Institute of Physiology, Dept of Neurophysiology, Faculty of Medicine Charite, Humboldt University, Tucholskystr 2, 10117 Berlin, Germany
Brain Res 1027:151-60. 2004..The present data suggest that glutamate transporters and group I/II mGluRs regulate excitatory synaptic transmission in the mEC. Presynaptic mGluRs may limit excessive glutamate accumulation if uptake becomes compromised...
- Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified culturesD Comoletti
Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy
J Neurol Sci 192:61-9. 2001....
- Dopamine release in the prefrontal cortex during stress is reduced by the local activation of glutamate receptorsA Del Arco
Department of Physiology, Faculty of Medicine, University Complutense, Madrid, Spain
Brain Res Bull 56:125-30. 2001..These results show that the local activation of prefrontal glutamatergic ionotropic receptors reduces the stress-induced dopamine release in the prefrontal cortex of the rat...
- Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemiaMartine Hamann
Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
Eur J Neurosci 15:308-14. 2002..These data are consistent with glutamate release being by reversal of neuronal transporters, and with uptake into glia being compromised by the ischaemia-evoked fall in the level of ATP needed to convert glutamate into glutamine...
- Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytesElena Alberdi
Departamento de Neurociencias, Universidad del Pais Vasco, Leioa, Vizcaya, Spain
Neurobiol Dis 9:234-43. 2002....
- NMDA and AMPA/kainate glutamatergic agonists increase the extracellular concentrations of GABA in the prefrontal cortex of the freely moving rat: modulation by endogenous dopamineAlberto Del Arco
Department of Physiology, Faculty of Medicine, University Complutense, Ciudad Universitaria s n, 28040 Madrid, Spain
Brain Res Bull 57:623-30. 2002....
- RNA synthesis-dependent potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated toxicity by antihistamine terfenadine in cultured rat cerebellar neuronsRamon Diaz-Trelles
Department of Biochemistry and Molecular Biology, University of Oviedo, Campus El Cristo, 33071 Oviedo, Spain
Neurosci Lett 345:136-40. 2003..Terfenadine reduced neuronal steady-state concentrations of [Ca2+](i) by approximately 75%. Our results suggest a role for histamine H1 receptors and intracellular calcium in the modulation of the excitotoxic response via AMPA receptors...
- Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neuronsTomofusa Yamauchi
Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
Neurosci Lett 347:155-8. 2003..These results suggest that dopamine inhibits glutamate induced-NOS activation via D1 receptor, resulting in the protection of retinal neurons...
- Depressor responses to L-proline microinjected into the rat ventrolateral medulla are mediated by ionotropic excitatory amino acid receptorsYumi Takemoto
Department of Neurophysiology, Division of Integrated Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
Auton Neurosci 120:108-12. 2005..The results indicate that the depressor response to L-proline in the CVLM includes mechanisms of ionotropic excitatory amino acid receptors...
- Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal culturesA Cristina Rego
Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
J Neurochem 86:792-804. 2003..Taken together, these data make important contributions to the elucidation of the downstream pathways activated in AMPA receptor-mediated excitotoxicity in cultured rat hippocampal neurones...
- Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analoguesJon Valgeirsson
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
Bioorg Med Chem 11:4341-9. 2003..Compounds 4a-h may be useful tools for the progressing pharmacophore mapping of the GluR5 agonist binding site...
- Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neuronsHui Fang Li
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, U S A
Br J Pharmacol 139:73-80. 2003..Both tyrosine kinase and PKC, but not PKA, appear to be essential for EtOH withdrawal hyper-responsiveness mediated by postsynaptic NMDA receptors in spinal cord motor neurons...
- Chronic nicotine causes functional upregulation of ionotropic glutamate receptors mediating hippocampal noradrenaline and striatal dopamine releaseFrancesca Risso
Sezione di Farmacologia e Tossicologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Viale Cembrano 4, Genoa 16148, Italy
Neurochem Int 44:293-301. 2004..Thus, chronic exposure to nicotine enhances the function of ionotropic glutamate receptors mediating noradrenaline release in the hippocampus and dopamine release in the striatum...
- Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disordersPaulo Roberto Louzada
Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brasil
FASEB J 18:511-8. 2004..GABAergic transmission may represent a promising target for the treatment of AD and other neurological disorders in which excitotoxicity plays a relevant role...
- Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currentsMatthew T Colonnese
Department of Biology, Department of Brain and Cognitive Science, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge 02139, USA
J Neurophysiol 89:57-68. 2003..Together the present data show that NR function is necessary for subsequent NR current regulation in vivo, but it is not essential for the developmental expression of normal AMPAR currents...
- Glutamatergic and serotonergic mechanisms in the dorsal facial area for common carotid artery blood flow control in the catChi Li Gong
Department of Physiology, School of Medicine, China Medical College, Taichung, Taiwan, ROC
Auton Neurosci 101:85-90. 2002..Such response may be suppressed by 5-HT2 action...
- Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effectWan Chen Lo
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, ROC
Eur J Pharmacol 454:39-45. 2002..They also suggested that CO and excitatory amino acids may interact in the nucleus tractus solitarii of rats...
- Long-term potentiation of the AMPA and NMDA components of minimal postsynaptic currents in rat hippocampal field Ca1I T Bayazitov
Institute of the Brain, Russian Academy of Medical Sciences, Moscow
Neurosci Behav Physiol 32:533-40. 2002....
- A proportional but slower NMDA potentiation follows AMPA potentiation in LTPAlanna J Watt
Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Neurosci 7:518-24. 2004..This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing...
- Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retinaSvein Harald Mørkve
University of Bergen, Department of Anatomy and Cell Biology, Bergen, Norway
J Physiol 542:147-65. 2002..Thus, our results indicate expression of high-affinity, voltage-sensitive AMPA receptors with significant Ca2+ permeability and relatively large single-channel chord conductances in AII amacrine cells...
- AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesinSu Jin Kim
Department of Molecular Cell Biology, Sungkyunkwan Univresity School of Medicine, Suwon 440 746, Korea
Exp Mol Med 36:98-102. 2004..These results suggest that glutamate-induced phosphorylation of moesin may be mediated through the AMPA receptor/RhoA/Rho kinase pathway...
- AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivoJuan Carlos Corona
Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
J Neurochem 89:988-97. 2004....
- AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposureShu Huei Hsiao
Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine MS 1114, College Station, TX 77843 1114, USA
Brain Res Dev Brain Res 142:89-99. 2003..Repeating this inhibition during early postnatal binge-like intoxication can augment normal development of AMPAR function...
- BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injurySandra M Garraway
Department of Neurobiology and Behavior, 550 Life Sciences Bldg, State University of New York, Stony Brook, New York 11794 5230, USA
J Neurophysiol 94:1798-804. 2005..It seems more likely that diminished trkB expression and enhanced expression of truncated trkB receptors in the contused cord play a significant role in determining the reduced effect of BDNF under these conditions...
- Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortexNeil J Bannister
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 25:5259-71. 2005..Thus, the developmental switch in transmission will dramatically alter information transfer at thalamocortical inputs to layer IV...
- TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticityNathalie Rouach
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
Nat Neurosci 8:1525-33. 2005....
- Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neuronsR Griffiths
Neurochemistry Group, School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
J Neurosci Res 48:533-42. 1997....
- Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamateTzu Hung Lin
Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
Eur J Pharmacol 589:37-44. 2008..Activation of both AMPA and NMDA receptors regulates the maturation of osteoblasts. NMDA but not AMPA affects receptor for activation of NF-kappaB ligand (RANKL)-induced osteoclastogenesis...
- Metabotropic glutamate receptors modulate the NMDA- and AMPA-induced gene expression in neocortical interneuronsKerstin Lindemeyer
Institute of Experimental and Clinical Pharmacology and Toxicology, Albert Ludwigs University, Freiburg, Germany
Cereb Cortex 16:1662-77. 2006..Our results suggest that mGluRIs regulate the glutamate-induced gene expression in neocortical interneurons in a physiologically relevant manner...
- Presynaptic modulation by somatostatin in the neostriatumVioleta Gisselle Lopez-Huerta
Departamento de Biofisica, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, PO Box 70 253, Mexico City, DF, 04510, Mexico
Neurochem Res 33:1452-8. 2008..In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts...
- Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleusStephan Michel
Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
BMC Neurosci 7:15. 2006....
- Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptorsIsaac Shemer
Department of Neuroscience, Retzius väg 8 A3 417, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 23:2035-47. 2006..We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors...
- Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in miceVinicius M Gadotti
Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040 900, SC, Brazil
Brain Res 1093:116-22. 2006....
- Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic densityMarco Feligioni
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
J Neurochem 99:549-60. 2006..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation...
- Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmissionEmiliano M Rial Verde
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Neuron 52:461-74. 2006..Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength...
- Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slicesShuqiu Zheng
Department of Anesthesiology, University of Virginia Health System, One Hospital Drive, P O Box 800710, Charlottesville, VA 22908 0710, USA
Brain Res 1054:143-51. 2005..Thus, isoflurane preconditioning reduced glutamate receptor overstimulation-induced neuronal injury/death. This neuroprotection may be PKC- and NOS-dependent...
- Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental areaEmanuela Argilli
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 28:9092-100. 2008....
- Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiatorP J Baumbarger
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Pharmacol Exp Ther 298:86-102. 2001..The therapeutic implications of AMPA receptor potentiators are discussed...
- Glutamate receptor subtypes in human retinal horizontal cellsWen Shen
Department of Physiology and Biophysics, University at Buffalo, Buffalo, NY 14214, USA
Vis Neurosci 21:89-95. 2004..The diversity of glutamate receptors in human horizontal cells suggests that synaptic input to these neurons may be multiplexed through both kainate and AMPA channels...
- Long-term potentiation of silent synapses in substantia gelatinosa neuronsSung Jun Jung
Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul 110 799, South Korea
Neuroreport 16:961-5. 2005....
- Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophreniaKuei Yuan Tseng
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
Biol Psychiatry 62:730-8. 2007....
- Rap2-JNK removes synaptic AMPA receptors during depotentiationYinghua Zhu
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Neuron 46:905-16. 2005....
- Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinaseG Fuller
Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
Brain Res Mol Brain Res 89:126-32. 2001..This provides evidence for a novel pathway linking striatal kainate receptors to ERK activation via PI3 kinase and MEK...
- Expression and regulation of Na pump isoforms in cultured cerebellar granule cellsT M Soga
Department of Biochemistry I, Yokohama City University School of Medicine, Yokohama, Japan
Neuroreport 12:829-32. 2001..The glutamate effects were mainly mediated by non-NMDA receptors. These results suggest that alpha1 isoform and alpha3/alpha2 isoforms are functionally important under basal conditions and after neuronal excitation, respectively...
- N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influxM Urushitani
Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyoku, Kyoto, Japan
J Neurosci Res 63:377-87. 2001..These data indicate that acute excitotoxicity in spinal neurons is mediated by mitochondrial Ca(2+) overload and ROS generation through the activation of NMDA receptors. This mechanism is different from that of chronic GNT...
- The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acidRasmus P Clausen
Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
Eur J Pharmacol 499:35-44. 2004....
- Ca2+ entry via AMPA-type glutamate receptors triggers Ca2+-induced Ca2+ release from ryanodine receptors in rat spiral ganglion neuronsRachel T Morton-Jones
Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand
Cell Calcium 43:356-66. 2008..These data demonstrate functional coupling between somatic AMPA-type glutamate receptors and intracellular Ca(2+) stores via RyR-dependent CICR in primary auditory neurons...
- Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampusC H Davies
Department of Pharmacology, University of Edinburgh, UK
J Physiol 496:451-70. 1996..regulation of AMPA and NMDA receptor-mediated EPSPs during various patterns of synaptic activation caused by the dynamic changes in GABA-mediated synaptic inhibition, which are orchestrated by GABAA autoreceptors in a frequency-dependent..
- Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptorsA Gorman
Division of Cell and Molecular Biology, School of Biological and Medical Sciences, University of Saint Andrews, Fife, Scotland, U K
Neuroscience 59:299-308. 1994..abstract truncated at 400 words)..
- Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitroR E Brown
Department of Neurophysiology, Institute for Neurobiology, Magdeburg, Germany
J Physiol 496:175-84. 1996..The mechanism by which histamine depresses transmission is independent of that used by class III metabotropic glutamate receptors...
- BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damageM J Leach
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, England, UK
Stroke 24:1063-7. 1993..Therefore, compounds that block the release of glutamate may be useful as cerebroprotective agents. The purpose of this study was to evaluate the cerebroprotective properties of a glutamate release inhibitor, BW619C89...
- Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out miceS Gylterud Owe
Department of Anatomy and Centre for Molecular Biology and Neuroscience CMBN, University of Oslo, P O Box 1105 Blindern, N0317 Oslo, Norway
Neuroscience 136:769-77. 2005....
- Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitroR D Traub
Department of Pharmacology, Division of Neuroscience, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom
J Neurophysiol 85:1246-56. 2001..We conclude that in 4-AP, axonal gap junctions could, at least in principle, account in part for both the large IPSPs, and for the antidromic activity in pyramidal neurons...
- Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytesB E Akinshola
Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
Brain Res Mol Brain Res 93:8-17. 2001....
- Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonistsJ N Sengupta
Division of Gastroenterology and Hepatology, MaccFund Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuroscience 125:711-23. 2004....
- Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in miceCristina Setim Freitas
Department of Pharmacology, Sector of Biological Sciences, Federal University of Parana, Curitiba, PR, Brazil
Basic Clin Pharmacol Toxicol 104:285-92. 2009..Moreover, the antinociceptive action demonstrated in the present study supports the ethnomedical uses of this plant...
- Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreasC D Weaver
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
Mol Pharmacol 54:639-46. 1998....
- Pharmacological characterization of harmaline-induced tremor activity in miceNeil E Paterson
Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
Eur J Pharmacol 616:73-80. 2009..Further, these data provide additional evidence for the roles of ionotropic glutamate, GABA(A) and dopamine D(2)/D(3) receptors in the neurobiology of harmaline-induced tremor...
- Xenon attenuates excitatory synaptic transmission in the rodent prefrontal cortex and spinal cord dorsal hornRainer Haseneder
Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
Anesthesiology 111:1297-307. 2009..In the current study, the authors examined the effects of xenon on synaptic transmission in the prefrontal cortex and the spinal cord dorsal horn (substantia gelatinosa)...
- Species-dependent functional properties of non-NMDA receptors expressed in Xenopus laevis oocytes injected with mammalian and avian brain mRNAD Bowie
Department of Pharmacology, School of Pharmacy, University of London
Br J Pharmacol 111:803-10. 1994..Our observations may reflect further heterogeneity of non-NMDA receptors in the central nervous system of different vertebrate species...
- Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbaceaR Sakai
School of Fisheries Sciences, Kitasato University, Kesen gun Sanriku cho, Iwate, Japan
J Pharmacol Exp Ther 296:650-8. 2001..This novel excitatory amino acid may prove useful for evaluating the physiological and pathological roles of non-NMDA receptors, especially KA receptors, in the central nervous system...
- Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentrationD T Joo
Department of Anesthesia, University of Toronto, Ontario, Canada
Anesthesiology 94:478-88. 2001..To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined...
- Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neuronsJ Y Chatton
Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland
J Pharmacol Exp Ther 299:1161-8. 2001..Both processes could provide the biochemical basis of the observed ifosfamide-associated encephalopathy...
- Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channelsLiping Huang
Department of Pharmacology and Toxicology, University of Otago, PO Box 913, Dunedin, New Zealand
J Pharm Pharmacol 60:1515-22. 2008..These data suggest that components common to the two oils are worthy of focus to identify the actives underlying the neuronal depressant and anti-agitation activities reported...
- Age-related functional changes of the glutamate receptor channels in rat Meynert neuronesN Akaike
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
J Physiol 504:665-81. 1997..The KA-induced IK(Ca), which developed with ageing, may thus function as one of the negative feedback systems, and thereby prevent excess cell excitation and neural damage, especially in adult rats...
- Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responsesAmy C Arai
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
Mol Pharmacol 62:566-77. 2002..The large gain in potency conferred by alkyl substitution suggests that the 5' substituent is in intimate contact with the receptor, with the size of the substituent determining the way in which receptor kinetics is changed...
- Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channelsJ O Malva
Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Portugal
Neurochem Int 32:7-16. 1998....
- Glutamatergic synaptic transmission participates in generating the hippocampal EEGL Stan Leung
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Hippocampus 14:510-25. 2004..Excitatory glutamatergic synaptic currents, activated by afferents from the entorhinal cortex and CA3, are suggested to participate in hippocampal EEG activities...
- [Update on anti-NMDA receptor encephalitis]Takahiro Iizuka
Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
Brain Nerve 62:331-8. 2010..In a recent case, a microscopic teratoma was detected on autopsy; therefore exploratory laparotomy may be considered in severe refractory cases...
- Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signallingOlivia F O'Leary
Neuroscience Centre, University of Helsinki, Finland
Psychoneuroendocrinology 34:367-81. 2009..Moreover, these effects were only observed in ovariectomized animals, thus suggesting that fluoxetine-induced increases in synaptic protein levels might only occur or become detectable when hippocampal synaptic connectivity is perturbed...
- Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in ratsPia Bäckström
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Psychopharmacology (Berl) 192:571-80. 2007..Nucleus accumbens glutamate transmission has been implicated in drug-seeking behavior, but the involvement of glutamate receptor subtypes in drug seeking maintained by drug-associated cues has not been fully investigated...
- Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and ratsHiroshi Yamashita
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
J Pharmacol Exp Ther 308:127-33. 2004..These results indicate that YM928 is a broad-spectrum anticonvulsant that would prove useful for the treatment of generalized seizure in human epileptic patients...
- Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in miceJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
Neurosci Lett 421:87-90. 2007..p. administration), deserves more attention as a potential antiepileptic drug for patients in status epilepticus...
- Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbitalMichael F Jackson
Department of Physiology, Medical Sciences Bldg, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
Mol Pharmacol 64:395-406. 2003..Our results suggest that PB does not act as an open channel blocker of AMPARs. Rather, the sensitivity, use dependence, and trapping of inhibition by PB are determined by AMPARs desensitization...
- Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slicesJ Harvey
Department of Pharmacology, Medical School, University of Birmingham
Br J Pharmacol 109:1085-90. 1993..It involves a Ca2+-sensitive process and is negatively regulated by protein kinase C...
- Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant miceD T Joo
Department of Anaesthesia, University of Toronto, Ontario, Canada
Anesthesiology 91:1329-41. 1999....
- Large variability in synaptic N-methyl-D-aspartate receptor density on interneurons and a comparison with pyramidal-cell spines in the rat hippocampusG Nyiri
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, PO Box 37, H 1450, Hungary
Neuroscience 119:347-63. 2003..Consequently, fast glutamatergic activation of interneurons is expected to show cell type-specific time course and state-dependent dynamics...
- Modulatory effects of dextran sulfate and fucoidan on binding and channel properties of AMPA receptors isolated from rat brainVishnu Suppiramaniam
Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Alabama 36849, USA
Synapse 60:456-64. 2006..These findings suggest that GAG components of proteoglycans can interact with and alter the binding affinity of AMPA receptors and modulate their functional properties...
- Excitatory and inhibitory modulation of taste responses in the hamster brainstemD V Smith
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201 1509, USA
Ann N Y Acad Sci 855:450-6. 1998..Microinjection of SP into the NST enhances the responses of many NST cells to gustatory stimulation; NaCl-best neurons are preferentially excited by SP...
- Mechanism of action of novel GluN2C NMDA receptor potentiatorsAlpa Khatri; Fiscal Year: 2013..The data from this research could potentially be useful for developing new therapies for neurological disorders thought to be associated with aberrant NMDA receptor function such as, schizophrenia, autism, and psychosis. ..
- Molecular mechanisms of excessive alcohol consumption and relapse-like behaviorREGINALD DEVON CANNADY; Fiscal Year: 2012..Key findings from these studies will provide novel insight into AMPAR-related mechanisms in excessive alcohol drinking behavior and vulnerability to relapse. ..
- Control of AMPAR Trafficking by NMDAR-Mediated PKD1 TranslocationEVA S LADOW; Fiscal Year: 2010..This research aims to investigate how neurons regulate the sensitivity of their connections in response to neuronal activity. ..
- AMPA Receptor Trafficking in SchizophreniaJOHN CHARLES HAMMOND; Fiscal Year: 2012..Accumulating evidence implicates glutamate receptors in schizophrenia. This project will examine glutamate receptor trafficking in this illness, ultimately leading to better diagnostic and treatment strategies. ..
- Regulation of D-serine Neuromodulation by PKCalpha and PICK1ASIF MUSTAFA; Fiscal Year: 2009..All this will primarily be accomplished by a combination of radiolabeling experiments, the use of pharmacological agents, mass spectrometry analysis, site-directed mutagenesis and the DsdA-LDH assay. ..
- SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUSRoger Nicoll; Fiscal Year: 2001....
- ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELSRoger Nicoll; Fiscal Year: 2006..abstract_text> ..
- Synaptic signaling regulated by MALS family PDZ proteinsRoger Nicoll; Fiscal Year: 2008..Because MALS proteins regulate growth factor receptors and interact with NMDA type glutamate receptors at synapses, this work will be relevant to both tissue development and synaptic plasticity. ..
- DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORSAMY ARAI; Fiscal Year: 2004..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
- Differential effects of TARPs on AMPA receptor subunitsAMY ARAI; Fiscal Year: 2008..unreadable] [unreadable]..
- PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAINSusan Carlton; Fiscal Year: 2004..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
- Non-Peptide Somatostatin Agonist AnalgesicsSusan Carlton; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Chemical Basis for Potassium Channel ModulationPAMELA ENGLAND; Fiscal Year: 2006..To determine the site(s) in HERG that interact with other proteins, photoreactive amino acids capable of forming protein cross-links will be site-specifically incorporated into the HERG. ..
- Accumbens-pallidal GABA and morphine reinforcementScott Hemby; Fiscal Year: 2005..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
- Ethanol and Presynaptic GABA beta Receptor FunctionJeffrey Weiner; Fiscal Year: 2007....
- The Role of Glutamate and CCK in the PBN in Taste ReactivityMichael King; Fiscal Year: 2007..Specifically, data collected during the proposed investigation will determine if glutamate and CCK in the PBN play a critical role in the assessment of ingested substances and subsequent behavioral responses. ..
- Mechanisms Underlying the Cognitive Function of SleepSubimal Datta; Fiscal Year: 2009....
- Hybrid Drugs: Novel Pharmacotherapy for ADHDFRANK TARAZI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NEUROBIOLOGICAL PARAMETERS OF COCAINE REINFORCEMENTScott Hemby; Fiscal Year: 2008..abstract_text> ..
- Neurodevelopmental ApoptosisNuri Farber; Fiscal Year: 2008..abstract_text> ..
- Stress-induced reinstatement of cocaine-seeking behaviorPeter Kalivas; Fiscal Year: 2008..abstract_text> ..
- Synaptic Correlates of Ethanol-Related BehaviorsJeffrey Weiner; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor CellsNuri Farber; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Entorhinal Transcriptome in SchizophreniaScott Hemby; Fiscal Year: 2009..To date, the treatment regimen, necropsy and tissue harvesting have been completed with both fresh frozen and paraffin-embedded EC available. ..
- Integrins and LTP consolidationGary Lynch; Fiscal Year: 2008..The results of these experiments are expected to provide a strong test of a specific hypothesis regarding how LTP, and therefore possibly memory, becomes consolidated. ..
- Effects of antipsychotic drugs on brain and behaviorFRANK TARAZI; Fiscal Year: 2005..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
- ELEMENTARY SCHOOL NEUROSCIENCE LITERACYGary Duncan; Fiscal Year: 2006..unreadable] [unreadable]..
- DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEMEdward Jones; Fiscal Year: 2003..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
- REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUNDPeter Kalivas; Fiscal Year: 2003..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
- Effects/Ethanol/Specific sites/AMPA glutamate receptorsBABATUNDE AKINSHOLA; Fiscal Year: 2004..This grant will contribute significantly to the career establishment and development of the investigator by providing the time, salary support and supplies needed for education and training in alcohol research in a minority institution. ..
- Kinase Inhibitors against NeurodegenerationGary Lynch; Fiscal Year: 2004....
- Norepinephrine Transporters: Targets for ADHDFRANK TARAZI; Fiscal Year: 2004..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
- NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEIDavid Linden; Fiscal Year: 2004..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
- ETHANOL AND SYNAPTIC GABAA RECEPTORSJeffrey Weiner; Fiscal Year: 2002....
- Ca permeable non-NMDAr: New spinal sensitization pathwayLinda Sorkin; Fiscal Year: 2005..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
- LONG TERM POTENTIATION AND DEPRESSION IN THE CEREBELLUMDavid Linden; Fiscal Year: 2002..In addition, these investigations have potential clinical relevance not only for cerebellar motor disorders, but also for disorders of learning and memory generally. ..
- CELL ASSEMBLIES, PATTERN COMPLETION AND THE AGING BRAINCarol Barnes; Fiscal Year: 2003..NMDA receptor antagonists are expected to prevent experience-dependent place field changes in the young rats, and AMPA current enhancers are expected to ameliorate place field properties in the old rats. ..
- NABTT-Consortium Therapeutic Studies of CNS MalignanciesStuart Grossman; Fiscal Year: 2008..abstract_text> ..
- HOMOCYSTEINE AND CONGENITAL HEART DEFECTSThomas Rosenquist; Fiscal Year: 2003..abstract_text> ..
- Can beta-lactam antibiotics decrease morphine physical dependence?SCOTT RAWLS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Annual Meeting of the American Pain SocietyLinda Sorkin; Fiscal Year: 2005..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
- Integrin and LTP ConsolidationGary Lynch; Fiscal Year: 2003..abstract_text> ..
- Dendritic Processing in the Olfactory BulbJason Christie; Fiscal Year: 2003..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
- Magnesium's Antihypertensive Effects in PreeclampsiaCYNTHIA STANDLEY; Fiscal Year: 2003..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
- Cardiovascular Response to Glutamate Nitric OxideWILLIAM TALMAN; Fiscal Year: 2006..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
- Mechanisms of Synaptic Depression: Focus on Rap Signaling PathwaysJ Julius Zhu; Fiscal Year: 2010..abstract_text> ..
- COMPUTATIONAL AND PHYSIOLOGICAL STUDY OF RETINAL NEURONSRobert Miller; Fiscal Year: 2004..The purpose of this research is to formulate models which will work in synergy to guide and enhance our experimental efforts to decipher to mechanisms that are critical for function among third-order retinal neurons. ..
- Altered hypothalamic-pituitary-adrenal function in the Fragile X mouseJULIE LAUTERBORN; Fiscal Year: 2007..unreadable] [unreadable]..
- Genetic Mapping of Functional Neural Networks & CircuitsCarol Barnes; Fiscal Year: 2006..abstract_text> ..
- Use-dependent intrinsic plasticity in the cerebellumDavid J Linden; Fiscal Year: 2010..Because these cellular and molecular processes are not only involved in memory storage, this work has implications for other brain diseases as well, including epilepsy and addiction. ..
- Myosin VI in Postsynaptic Function and PlasticityEmily Osterweil; Fiscal Year: 2004..Myosin VI may be similarly critical for postsynaptic function and plasticity, deficits in which are seen in Down's syndrome, fragile X syndrome, and epilepsy. ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- Genetic Dissection of Brain Reward CircuitsLARRY ZWEIFEL; Fiscal Year: 2008..abstract_text> ..
- NEURAL MECHANISMS OF VOCAL LEARNINGSARAH BOTTJER; Fiscal Year: 2009..abstract_text> ..
- Molecular Diagnosis Utilizing Cerebrospinal FluidSTEPHEN GINSBERG; Fiscal Year: 2003..abstract_text> ..
- Alterations in chemoafferent integration induced by chronic intermittent hypoxiaSTEVEN MIFFLIN; Fiscal Year: 2008..These factors mediate much of the pathology associated with sleep apnea including hypertension, increased risk of adverse cardiovascular events and insulin resistance. [unreadable] [unreadable] [unreadable]..
- International Congress of NeuroethologySARAH BOTTJER; Fiscal Year: 2004..Thus, benefits to American scientists in general, and to young investigators in particular, will be the opportunity for exposure to cutting-edge research and techniques from around the World. ..
- Lesion Induced Synaptic PlasticitySTEPHEN GINSBERG; Fiscal Year: 2004....
- Cannabinoid Regulation of Basal Ganglia Glutamate and GABASCOTT RAWLS; Fiscal Year: 2007..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
- Cellular Plasticity Following Repeated AmphetamineChristopher Nelson; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Nitric Oxide Regulation of Platelet Granule ExocytosisCRAIG MORRELL; Fiscal Year: 2008..Therefore, strategies to minimize granule exocytosis may prove valuable in the acute treatment of pro-thrombotic diseases. (End of Abstract) [unreadable] [unreadable]..
- Cerebellar Circuitry and Plasticity in an Electric FishVictor Han; Fiscal Year: 2007..The primary method will be whole-cell patch recordingin in vitro slices, combined with labelingof recorded elements for morphologicalidentification. ..
- CARDIOVASCULAR RESPONSES TO CHRONIC INTERMITTENT HYPOXIASTEVEN MIFFLIN; Fiscal Year: 2003....
- GABA MECHANISMS IN BARORECEPTOR INTEGRATION IN NTSSTEVEN MIFFLIN; Fiscal Year: 2004..Therefore, understanding the mechanisms that induce and underlie these adaptations will be of great importance in our understanding of cardiovascular regulation in hypertension. ..