miconazole

Summary

Summary: An imidazole antifungal agent that is used topically and by intravenous infusion.

Top Publications

  1. ncbi [Drug-drug interaction of antifungal drugs]
    Toshiro Niwa
    Post Marketing Product Development, Astellas Pharma Inc, Osaka, Japan
    Yakugaku Zasshi 125:795-805. 2005
  2. ncbi Antifungal activity of miconazole against recent Candida strains
    N Isham
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106, USA
    Mycoses 53:434-7. 2010
  3. pmc Synergistic effects of miconazole and polymyxin B on microbial pathogens
    Silvia Pietschmann
    Charite Universitatsmedizin Berlin, Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Virchow Klinikum, Berlin, Germany
    Vet Res Commun 33:489-505. 2009
  4. pmc Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy
    Sara B Snell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 88:596-603. 2012
  5. ncbi Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures
    S Caretto
    Istituto di Scienze delle Produzioni Alimentari, CNR, Lecce, Italy
    Plant Biol (Stuttg) 13:51-8. 2011
  6. pmc Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery
    Mangesh R Bhalekar
    AISSMS College of Pharmacy, Kennedy Road, Pune, India
    AAPS PharmSciTech 10:289-96. 2009
  7. ncbi Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromycesflavus FKI-0076
    Masayoshi Arai
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 55:172-80. 2002
  8. ncbi Inhibition of sarcoplasmic reticulum Ca2+-ATPase by miconazole
    Antonio Lax
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30071 Espinardo, Murcia, Spain
    Am J Physiol Cell Physiol 283:C85-92. 2002
  9. ncbi Eberconazole 1% cream is an effective and safe alternative for dermatophytosis treatment: multicenter, randomized, double-blind, comparative trial with miconazole 2% cream
    Trinidad Repiso Montero
    CAP Sant Andreu, Barcelona, Spain
    Int J Dermatol 45:600-4. 2006
  10. ncbi The use of rifampicin-miconazole-impregnated catheters reduces the incidence of femoral and jugular catheter-related bacteremia
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Clin Infect Dis 47:1171-5. 2008

Detail Information

Publications220 found, 100 shown here

  1. ncbi [Drug-drug interaction of antifungal drugs]
    Toshiro Niwa
    Post Marketing Product Development, Astellas Pharma Inc, Osaka, Japan
    Yakugaku Zasshi 125:795-805. 2005
    ..pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole...
  2. ncbi Antifungal activity of miconazole against recent Candida strains
    N Isham
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106, USA
    Mycoses 53:434-7. 2010
    b>Miconazole (MICON) has long been used for the topical treatment of mucosal candidiasis...
  3. pmc Synergistic effects of miconazole and polymyxin B on microbial pathogens
    Silvia Pietschmann
    Charite Universitatsmedizin Berlin, Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Virchow Klinikum, Berlin, Germany
    Vet Res Commun 33:489-505. 2009
    ..To assess the value of an antibiotic combination of polymyxin B and miconazole this study examined the in vitro synergistic potential of the two drugs on Gram-negative and Gram-positive ..
  4. pmc Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy
    Sara B Snell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 88:596-603. 2012
    ..Based on the ability of the antifungal miconazole to induce ROS in Candida, we tested several azole antifungals for their ability to augment PDT in vitro...
  5. ncbi Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures
    S Caretto
    Istituto di Scienze delle Produzioni Alimentari, CNR, Lecce, Italy
    Plant Biol (Stuttg) 13:51-8. 2011
    ..annua suspension cultures were established in order to investigate the effects of methyl jasmonate (MeJA) and miconazole on artemisinin biosynthesis...
  6. pmc Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery
    Mangesh R Bhalekar
    AISSMS College of Pharmacy, Kennedy Road, Pune, India
    AAPS PharmSciTech 10:289-96. 2009
    The purpose of this study was to prepare miconazole nitrate (MN) loaded solid lipid nanoparticles (MN-SLN) effective for topical delivery of miconazole nitrate...
  7. ncbi Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromycesflavus FKI-0076
    Masayoshi Arai
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 55:172-80. 2002
    ..FKI-0076, a soil isolate, was found to produce compounds which reinforce the anti-Candida albicans activity of miconazole. Four structurally related compounds, a novel one, designated actofunicone, and the knowns deoxyfunicone, ..
  8. ncbi Inhibition of sarcoplasmic reticulum Ca2+-ATPase by miconazole
    Antonio Lax
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30071 Espinardo, Murcia, Spain
    Am J Physiol Cell Physiol 283:C85-92. 2002
    The inhibition of sarcoplasmic reticulum Ca2+-ATPase activity by miconazole was dependent on the concentration of ATP and membrane protein...
  9. ncbi Eberconazole 1% cream is an effective and safe alternative for dermatophytosis treatment: multicenter, randomized, double-blind, comparative trial with miconazole 2% cream
    Trinidad Repiso Montero
    CAP Sant Andreu, Barcelona, Spain
    Int J Dermatol 45:600-4. 2006
    ..The purpose of this trial was to evaluate the efficacy of eberconazole 1% cream compared with miconazole 2% cream in the treatment of dermatophytoses.
  10. ncbi The use of rifampicin-miconazole-impregnated catheters reduces the incidence of femoral and jugular catheter-related bacteremia
    Leonardo Lorente
    Department of Critical Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Clin Infect Dis 47:1171-5. 2008
    ..In previous studies, we have found a higher incidence of central venous catheter-related bacteremia among patients with femoral and central jugular accesses than among patients with other venous accesses...
  11. ncbi Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae
    Davy Vandenbosch
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    FEMS Yeast Res 13:720-30. 2013
    ..Previous research has shown that 1-10% of sessile Candida cells survive treatment with high doses of miconazole (a fungicidal imidazole)...
  12. ncbi Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin
    M Kovac
    Haemostasis Department, Blood Transfusion Institute of Serbia, Belgrade, Serbia
    J Clin Pharm Ther 37:45-8. 2012
    Medline search disclosed 10 case reports of interactions between oral anticoagulants and miconazole oral gel, but none so far between nystatin solution and anticoagulants...
  13. ncbi Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor
    Cedric Duret
    INSERM U632, Hepatic Physiopathology, 1919 Route de Mende, 34293 Montpellier, France
    Mol Pharmacol 70:329-39. 2006
    ..In the current study, we investigated the effect of ketoconazole and other azole-derived drugs, miconazole and fluconazole, on the transcriptional activity of the human GR (hGR) in HeLa and HepG2 cells, and in primary ..
  14. ncbi Formulation and drying of miconazole and itraconazole nanosuspensions
    Ana M Cerdeira
    Cilag AG, Hochstrasse 201, 8205 Schaffhausen, Switzerland
    Int J Pharm 443:209-20. 2013
    b>Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect...
  15. ncbi Upscaling of the hot-melt extrusion process: comparison between laboratory scale and pilot scale production of solid dispersions with miconazole and Kollicoat IR
    Sandra Guns
    Laboratory of Pharmacotechnology and Biopharmacy, KU Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 81:674-82. 2012
    ..b>Miconazole and Kollicoat IR were used as model drug and carrier for this study...
  16. ncbi In vitro antimicrobial activity of miconazole and polymyxin B against canine meticillin-resistant Staphylococcus aureus and meticillin-resistant Staphylococcus pseudintermedius isolates
    Filip Boyen
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Dermatol 23:381-5, e70. 2012
    ..Meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections are increasingly reported in dogs, and these bacteria may be isolated from ear infections...
  17. ncbi Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938
    Takashi Fukuda
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 61:550-5. 2008
    ..Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.
  18. pmc Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole
    Anna Bink
    Centre of Microbial and Plant Genetics, CMPG, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium
    Antimicrob Agents Chemother 55:4033-7. 2011
    We investigated the cellular mechanisms responsible for the occurrence of miconazole-tolerant persisters in Candida albicans biofilms. Miconazole induced about 30% killing of sessile C. albicans cells at 75 μM...
  19. ncbi The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg)
    Seema Menon
    Reproductive Research Unit, Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 16:703-6. 2007
    To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis.
  20. ncbi Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%
    P Concannon
    Royal North Shore Hospital, St. Leonards, New South Wales, Australia
    Pediatr Dermatol 18:149-55. 2001
    ..This placebo-controlled, randomized, double-blind, parallel-group trial compared the efficacy and safety of miconazole nitrate 0...
  21. ncbi Efficacy and tolerability of sertaconazole nitrate 2% cream vs. miconazole in patients with cutaneous dermatophytosis
    A Sharma
    Medical Services, Glenmark Pharmaceuticals Ltd, Mumbai, India
    Mycoses 54:217-22. 2011
    Sertaconazole is a new antifungal agent. To compare the efficacy and tolerability of sertaconazole and miconazole cream in cutaneous dermatophytosis, this prospective, randomized, multicentric comparative, phase 4 study was undertaken in ..
  22. ncbi Preparation of a novel iodide-selective electrode based on iodide-miconazole ion-pair and its application to pharmaceutical analysis
    Fahimeh Jalali
    Department of Chemistry, Faculty of Sciences, Razii University, Kermanshah, Iran
    Anal Sci 21:1533-5. 2005
    An iodide-miconazole ion-paired complex was used as a suitable ion-exchanger for the preparation of a plasticized-PVC membrane electrode...
  23. pmc Blockade of HERG cardiac K+ current by antifungal drug miconazole
    Kan Kikuchi
    Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan
    Br J Pharmacol 144:840-8. 2005
    1. Miconazole, an imidazole antifungal agent, is associated with acquired long QT syndrome and ventricular arrhythmias...
  24. ncbi Swelling-controlled release system for the vaginal delivery of miconazole
    T K Mandal
    Division of Pharmaceutics, College of Pharmacy, Xavier University of Louisiana, New Orleans LA 70125, USA
    Eur J Pharm Biopharm 50:337-43. 2000
    b>Miconazole nitrate, a fungicidal, is effective for the local treatment of vaginitis. The objective of this project was to develop a swelling-controlled release delivery system for miconazole...
  25. ncbi Fungicidal activity of miconazole against Candida spp. biofilms
    Davy Vandenbosch
    Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Antimicrob Chemother 65:694-700. 2010
    Although azole antifungals are considered to be fungistatic, miconazole has fungicidal activity against planktonic Candida albicans cells, presumably associated with the induction of reactive oxygen species (ROS) production...
  26. ncbi Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis
    Massoud Amanlou
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14155 6451, Iran
    Phytother Res 20:966-9. 2006
    An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy of a miconazole 2% gel compared with Zataria multiflora 0...
  27. pmc Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect
    Daisuke Kobayashi
    Department of Clinical Laboratory Medicine Division of Laboratory Diagnosis, Sapporo Medical University School of Medicine, Japan
    Antimicrob Agents Chemother 46:3113-7. 2002
    We investigated the significance of endogenous reactive oxygen species (ROS) produced by fungi treated with miconazole. ROS production in Candida albicans was measured by a real-time fluorogenic assay...
  28. ncbi Reduced colonization and infection with miconazole-rifampicin modified central venous catheters: a randomized controlled clinical trial
    Nedim Yucel
    2nd Department of Surgery, Klinikum Merheim, Germany
    J Antimicrob Chemother 54:1109-15. 2004
    Central venous catheters (CVC) are a major cause of nosocomial bloodstream infections. Catheters modified with miconazole and rifampicin that constantly and slowly release antimicrobial substances are assumed to be beneficial in reducing ..
  29. ncbi Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole
    Riina Rautemaa
    Department of Microbiology and Immunology, Haartman Institute, University of Helsinki, Finland
    Scand J Infect Dis 40:904-7. 2008
    ..Significantly more y of usage of ketoconazole and miconazole preceded the isolation of strains with decreased susceptibility to fluconazole than susceptible isolates (p=0...
  30. ncbi Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 180:22-35. 2002
    b>Miconazole (MIC), a promising oral antifungal agent, has been used worldwide in the treatment of superficial mycosis...
  31. ncbi Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients
    Rene Jean Bensadoun
    Department of Radiation Oncology, Antoine Lacassagne Center, Nice, France
    Cancer 112:204-11. 2008
    ..b>Miconazole Lauriad 50-mg mucoadhesive buccal tablet (MBT) Loramyc reportedly delivered rapid and prolonged, effective ..
  32. ncbi Inhibitory effect of miconazole on melanogenesis
    Yeun Ja Mun
    Department of Herbal Resources, Wonkwang University, Iksan, Jeonbuk, Korea
    Biol Pharm Bull 27:806-9. 2004
    b>Miconazole (MIC), a regional antifungal agent, has been used worldwide in the treatment of superficial mycosis. However, the effect of MIC on skin pigmentation is not known...
  33. ncbi Topical corticosteroids in association with miconazole and chlorhexidine in the long-term management of atrophic-erosive oral lichen planus: a placebo-controlled and comparative study between clobetasol and fluocinonide
    M Carbone
    Department of Oral Medicine, School of Medicine and Dentistry, University of Turin, Italy
    Oral Dis 5:44-9. 1999
    ..To evaluate the efficacy of a combination of topical corticosteroids with topical antimycotic drugs in the therapy of atrophic-erosive forms of oral lichen planus (OLP)...
  34. ncbi Comparative efficacy of topical therapy with a slow-release mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with ketoconazole in HIV-positive patients with oropharyngeal candidiasis
    Jens Van Roey
    Tibotec BVBA, Mechelen, Belgium
    J Acquir Immune Defic Syndr 35:144-50. 2004
    This randomized comparative study assessed the efficacy and safety of a 10-mg once-daily topical regimen of miconazole nitrate mucoadhesive buccal tablet (n = 178) versus a 400-mg once-daily systemic regimen of ketoconazole (n = 179) in ..
  35. ncbi Susceptibility to 5-fluorocytosine, miconazole and amphotericin B of Candida albicans strains isolated from the throat of non-AIDS patients
    Gloria Luz Paniagua
    Facultad de Estudios Superiores Iztacala, UNAM
    Rev Latinoam Microbiol 44:65-8. 2002
    ..Minimal inhibitory concentrations (MIC) of 5-fluorocytosine, miconazole and amphotericin B were determined by microtiter broth dilution...
  36. ncbi Randomized, comparative, double-blind, double-dummy, multicenter trial of miconazole buccal tablet and clotrimazole troches for the treatment of oropharyngeal candidiasis: study of miconazole Lauriad® efficacy and safety (SMiLES)
    Jose A Vazquez
    Division of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan 48201, USA
    HIV Clin Trials 11:186-96. 2010
    ..Once-daily miconazole 50 mg buccal tablet (MBT) is a novel delivery system using an extended-spectrum azole with potent in vitro ..
  37. ncbi Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing
    Noha A Nafee
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
    Int J Pharm 264:1-14. 2003
    Mucoadhesive patches containing 10mg miconazole nitrate were evaluated...
  38. ncbi Lipid-covered drug particles: combined action of dioctadecyldimethylammonium bromide and amphotericin B or miconazole
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970, Sao Paulo SP, Brazil
    J Antimicrob Chemother 58:66-75. 2006
    Coverage of antifungal drug particles (miconazole and amphotericin B) with cationic lipid and evaluation of a synergistic action between lipid and drug.
  39. ncbi In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole
    Guo Xian Wei
    Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    J Antimicrob Chemother 53:750-8. 2004
    ..In this study we examined the MUC7 12-mer antifungal activity alone or in combination with other antifungal agents in LYM medium (modified RPMI 1640)...
  40. ncbi Preparation and in vitro/in vivo evaluation of the buccal bioadhesive properties of slow-release tablets containing miconazole nitrate
    Fergany A Mohammed
    Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Drug Dev Ind Pharm 29:321-37. 2003
    Slow-release buccal bioadhesive tablets of miconazole nitrate were prepared by using polymer mixtures of buccoadhesive materials such as hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol 934p, and sodium alginate...
  41. ncbi Physical and chemical stability of miconazole liposomes prepared by supercritical aerosol solvent extraction system (ASES) process
    Sarinnate Kunastitchai
    Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Pharm Dev Technol 12:361-70. 2007
    The aerosol solvent extraction system (ASES) process was applied to prepare miconazole (MCZ) liposomes in a dry and reconstitutable form, the optimized temperature and pressure of which were 35 degrees C and 8.0 MPa, respectively...
  42. ncbi Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%
    Erin M Warshaw
    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Acad Dermatol 53:717-20. 2005
    ..double-blind, placebo-controlled, randomized trial involving 48 participants was to determine if biweekly miconazole powder prevents onychomycosis recurrence...
  43. ncbi Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342
    Takashi Fukuda
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 59:480-5. 2006
    ..Tensidols A and B potentiated miconazole activity against Candida albicans...
  44. pmc Comparison of the pharmacokinetics of miconazole after administration via a bioadhesive slow release tablet and an oral gel to healthy male and female subjects
    J M Cardot
    Laboratoire de Biopharmacie, Faculte de Pharmacie, 28 Place Henri Dunant, BP 38, F 63001 Clermont Ferrand, France
    Br J Clin Pharmacol 58:345-51. 2004
    The aim of this study was to compare salivary miconazole pharmacokinetics following once daily application of bioadhesive tablets (50 or 100 mg), vs the current treatment with a gel (3 times a day, 375 mg day(-1)).
  45. ncbi Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis
    Fabio Peixoto
    Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil
    Int J Gynaecol Obstet 102:287-92. 2008
    To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.
  46. ncbi The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures
    Alessandra Queiroga Gonçalves
    Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Rev Inst Med Trop Sao Paulo 49:201-2. 2007
    ..The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E...
  47. ncbi Susceptibility of Candida albicans biofilms grown in a constant depth film fermentor to chlorhexidine, fluconazole and miconazole: a longitudinal study
    Hanadi Lamfon
    Division of Infection and Immunity, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Antimicrob Chemother 53:383-5. 2004
    ..The aim of this study was to assess the resistance of Candida albicans biofilms to both antifungal and antimicrobial agents in vitro...
  48. ncbi Miconazole induces changes in actin cytoskeleton prior to reactive oxygen species induction in yeast
    Karin Thevissen
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Heverlee, Belgium
    J Biol Chem 282:21592-7. 2007
    The antifungal compound miconazole inhibits ergosterol biosynthesis and induces reactive oxygen species (ROS) in susceptible yeast species...
  49. ncbi New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. II. Structure elucidation
    Takashi Fukuda
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 57:117-24. 2004
    The structures of beauvericins D, E and F, novel potentiators of miconazole activity against Candida albicans produced by Beauveria sp...
  50. ncbi Preparation, characterization, and evaluation of miconazole-cyclodextrin complexes for improved oral and topical delivery
    S Tenjarla
    Department of Pharmaceutical Sciences, Mercer University, Atlanta, Georgia 30341, USA
    J Pharm Sci 87:425-9. 1998
    The solubility of miconazole in water increased in the presence of cyclodextrins (CDs)...
  51. ncbi Application of nuclear magnetic resonance spectroscopy for quantitative analysis of miconazole, metronidazole and sulfamethoxazole in pharmaceutical and urine samples
    A A Salem
    Department of Chemistry, Faculty of Science, UAE University, Al Ain, UAE
    J Pharm Biomed Anal 41:654-61. 2006
    Specific, accurate and precise NMR methods were developed for determining miconazole, metronidazole and sulfamethoxazole antibiotic drugs in authentic, pharmaceutical and urine samples...
  52. ncbi Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections
    E Ozyurt
    Onur Medical Research Ltd, Istanbul, Turkey
    Int J Gynaecol Obstet 74:35-43. 2001
    OBJECTIVE: To evaluate the efficacy of Neo-Penotran pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections...
  53. ncbi Determination of miconazole in pharmaceutical creams using internal standard and second derivative spectrophotometry
    K Wrobel
    Instituto de Investigaciones Cientificas, Universidad de Guanajuato, Guanajuato, Mexico
    J Pharm Biomed Anal 20:99-105. 1999
    A simple method is proposed for miconazole determination in pharmaceutical creams, based on extraction and second derivative spectrophotometry. In the presence of sodium lauryl sulfate (0.5%) and sulphuric acid (0...
  54. ncbi L(9) orthogonal design assisted formulation and evaluation of chitosan-based buccoadhesive films of miconazole nitrate
    S Tiwari
    Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India
    Curr Drug Deliv 6:305-16. 2009
    The present study was aimed to prepare and evaluate buccoadhesive films of miconazole nitrate (MCZ)...
  55. pmc Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4
    Juha Grönlund
    Department of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine, University of Turku, P O Box 52, Kiinamyllynkatu 4 8, FI 20520 Turku, Finland
    Antimicrob Agents Chemother 55:1063-7. 2011
    Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone...
  56. ncbi Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs
    H Y Aboul-Enein
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Fresenius J Anal Chem 370:951-5. 2001
    Resolution of the enantiomers of (+/-)-econazole, (+/-)-miconazole, and (+/-)-sulconazole has been achieved on different normal-phase chiral amylose columns, Chi-ralpak AD, AS, and AR...
  57. ncbi In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures
    Guo Xian Wei
    Department of Pediatric Dentistry, University of Illinois at Chicago, College of Dentistry, MC850, Chicago, IL 60612 7212, USA
    Arch Oral Biol 56:565-72. 2011
    ..To investigate the antimycotic activity of the plant alkaloid berberine (BBR), alone and in combination with antifungal azoles, against planktonic and biofilm Candida cultures...
  58. ncbi Dynamics of skin barrier repair following topical applications of miconazole nitrate
    E Xhauflaire-Uhoda
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Skin Pharmacol Physiol 19:290-4. 2006
    ..Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to compare the effect of pastes (petrolatum and 15% zinc oxide) containing or not ..
  59. ncbi Superficial distribution and identification of antifungal/antimicrobial agents on a modified tissue conditioner by SEM-EDS microanalysis: a preliminary study
    Vanessa Migliorini Urban
    School of Dentistry, Camilo Castelo Branco University, Campus Itaquera, Sao Paulo, Brazil
    J Prosthodont 18:603-10. 2009
    ..This study evaluated the incorporation pattern of antifungal/antimicrobial agents added to a tissue conditioner by scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS) analysis...
  60. ncbi Spectrophotometric resolution of metronidazole and miconazole nitrate in ovules using ratio spectra derivative spectrophotometry and RP-LC
    N Erk
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, Tandogan, 06100 Ankara, Turkey
    J Pharm Biomed Anal 25:115-22. 2001
    Metronidazole and miconazole nitrate in ovules was determined by ratio spectra derivative spectrophotometry and by high-performance liquid chromatography (HPLC)...
  61. ncbi Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model
    R A Lubet
    National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, MD, USA
    Int J Cancer 72:95-101. 1997
    The chemopreventive efficacy of N-acetyl-L-cysteine (NAC), anethole trithione, miconazole and phenethylisothiocyanate (PEITC), each of which would be expected to alter carcinogen metabolism, was examined in the dimethylbenzanthracene (..
  62. ncbi Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro
    Cesar A B Nava-Ortiz
    Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico DF 04510, Mexico
    Acta Biomater 6:1398-404. 2010
    ..functionalization with CDs provided PE and PP with the capability to incorporate the anti-fungal drug miconazole (up to 0.27 mg cm(-2)), leading to reduced biofilm formation by C. albicans in an in vitro biofilm model system...
  63. pmc Membrane rafts are involved in intracellular miconazole accumulation in yeast cells
    Isabelle E J A Francois
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium
    J Biol Chem 284:32680-5. 2009
    ..We demonstrated previously that miconazole induces actin cytoskeleton stabilization in Saccharomyces cerevisiae prior to induction of reactive oxygen ..
  64. ncbi Miconazole: a historical perspective
    Annette W Fothergill
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Expert Rev Anti Infect Ther 4:171-5. 2006
    b>Miconazole is an imidazole that has been successfully used for over 30 years for the treatment of superficial and cutaneous disease. This agent is distinguished from other azoles by possessing two mechanisms of action...
  65. ncbi Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide
    Valery Barillaro
    Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Liege, CHU Tour 4, Bat B36, Avenue de l Hopital, 1, 4000 Liege 1, Belgium
    J Pharm Pharm Sci 7:378-88. 2004
    The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing.
  66. ncbi The effects of amphotericin B, fluconazole and miconazole on neutrophil and lymphocyte function in a guinea pig model
    D C Drummond
    University of Queensland, Department of Medicine and Infectious Diseases, Mater Misericordiae Hospital, South Brisbane, Australia
    J Antimicrob Chemother 36:375-84. 1995
    We studied the effects of amphotericin B, fluconazole and miconazole on guinea pig neutrophil and lymphocyte function. Neutrophil adherence, chemotaxis, and deoxyglucose uptake and mitogen-induced lymphocyte proliferation were examined...
  67. ncbi [The comparison of susceptibility of Candida albicans and Candida glabrata to miconazole]
    P Kurnatowski
    , ,
    Wiad Parazytol 47:867-73. 2001
    ..strains isolated from patietnts treated in Centre for Treatment of Parasitic Diseases and Mycoses - to miconazole using MIC. 96.5% of strains were sensitive to miconazole; values of MIC for C. albicans were lower than for C...
  68. ncbi [Susceptibility to itraconazole and miconazole of fungi strains isolated from the vaginal ontocenosis]
    A Kurnatowska
    Katedra Biologii i Parazytologii Lekarskiej, , ,
    Wiad Parazytol 47:131-5. 2001
    The activity of itraconazole (RO 51211, molecular weight 705,64) and miconazole (RO 14889, molecular weight 479,15) obtained from Janssen Pharmaceutica NV, against 100 fungi strains, was studied...
  69. ncbi Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties
    Takashi Fukuda
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 58:309-14. 2005
    ..Citridones (75 microM) potentiate the miconazole activity against Candida albicans, decreasing the IC50 value of miconazole from 14.5 nM to 3...
  70. ncbi Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132
    Takashi Fukuda
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 58:252-9. 2005
    ..They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans...
  71. ncbi In vitro susceptibility of oral Candida to seven antifungal agents
    T Kuriyama
    Department of Oral Surgery, Medicine and Pathology, School of Dentistry, Cardiff University, Cardiff, UK
    Oral Microbiol Immunol 20:349-53. 2005
    The in vitro susceptibility of 618 Candida isolates to fluconazole, itraconazole, voriconazole, ketoconazole, miconazole, amphotericin B, and nystatin was determined...
  72. ncbi In vitro efficacy of a buffered chelating solution as an antimicrobial potentiator for antifungal drugs against fungal pathogens obtained from horses with mycotic keratitis
    William L Weinstein
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 67:562-8. 2006
    ....
  73. ncbi Antifungal susceptibility of epigallocatechin 3-O-gallate (EGCg) on clinical isolates of pathogenic yeasts
    Bong Joo Park
    The United Graduate School of Veterinary Sciences, Gifu University, 1 1 Yanagido, Gifu, Gifu 501 1193, Japan
    Biochem Biophys Res Commun 347:401-5. 2006
    ..agents, amphotericin B (AMPH), fluconazole (FLCZ), flucytosin (5FC), itraconazole (ITCZ), micafungin (MCFG), and miconazole (MCZ), using a method following the National Committee for Clinical Laboratory Standards (NCCLS) M27-A ..
  74. ncbi [Antifungal susceptibility among the isolates of yeast from the University Hospital of the Ryukyus]
    Chiaki Ohta
    Clinical Laboratories, University Hospital of the Ryukyus, Nishihara, Nakagami Okinawa
    Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 16:127-33. 2005
    ..tropicalis and C. glabrata were estimated as being 40.6% and 13.7%, respectively. The activities of miconazole and micafungin were the most potent with MICs50, 0.125 and 0.06 microg/ml. However, the MICs of C...
  75. ncbi Anticandidial activity of some essential oils of a mega biodiversity hotspot in India
    B K Dutta
    Biotechnology Division, Defence Research Laboratory, Tezpur, Assam, India
    Mycoses 50:121-4. 2007
    ..Callistemon lanceolatus, Cinnamomum camphora, Citrus limon, Tagetes petula, as well as two standard antibiotics, miconazole and clotrimazole, were tested in vitro for their anticandidial activity...
  76. ncbi Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S. mutans, S. mitis and C. albicans
    Laurylene César de Souza Vasconcelos
    Departament of Clinical and Social Dentistry, Federal University of Paraiba, Joao Pessoa, PB, Brazil
    Braz Dent J 17:223-7. 2006
    ..was to investigate the antimicrobial effect of a Punica granatum Linn (pomegranate) phytotherapeutic gel and miconazole (Daktarin oral gel) against three standard streptococci strains (mutans ATCC 25175, sanguis ATCC 10577 and mitis ..
  77. ncbi Azole therapy of clinical and experimental coccidioidomycosis
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, 751 So Bascom Avenue, San Jose, CA 95128 2699, USA
    Ann N Y Acad Sci 1111:442-54. 2007
    ..advances in the pharmacologic and antimicrobial properties of this class since the initial introduction of miconazole, and many patients with coccidioidomycosis have benefited...
  78. ncbi Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs
    E Bensignor
    Dermatology Referral Service, 6 rue Mare Pavée, 35510 Cesson Sevigne, France
    Vet Rec 158:193-5. 2006
    ..clotrimazole, marbofloxacin and dexamethasone, and in the other ear with a topical antifungal containing miconazole. The effects of the treatments were analysed on the basis of the scores for pruritus, erythema and amount of ..
  79. ncbi Modification of the fluorescein diacetate assay for screening of antifungal agents against Candida albicans: comparison with the NCCLS methods
    Nynke Brouwer
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    J Microbiol Methods 66:234-41. 2006
    ..1%, 0.1% and 1% w/v, respectively) and buffered with 10 mM BES buffer. The MICs of amphotericin B, fluconazole, miconazole and flucytosine (representing three major classes of antifungal agents) obtained by the three methods were ..
  80. ncbi Deep fungal dermatitis in three inland bearded dragons (Pogona vitticeps) caused by the Chrysosporium anamorph of Nannizziopsis vriesii
    Michelle R Bowman
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, USA
    Med Mycol 45:371-6. 2007
    ..This lizard died while undergoing itraconazole and topical miconazole therapy...
  81. ncbi Feasibility of using collagen as the base of the antifungal drug, miconazole
    K Yoshida
    Department of Removable Prosthodontics, Matsumoto Dental University, Nagano, Japan
    J Oral Rehabil 33:363-7. 2006
    The feasibility of using collagen as the base of miconazole was investigated...
  82. pmc Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues
    K Suresh Babu
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    J Med Chem 49:7877-86. 2006
    ....
  83. ncbi Identification and in vitro antifungal susceptibility testing of 200 clinical isolates of Candida spp. responsible for fingernail infections
    Valda Teixeira Figueiredo
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, PO Box 486, 31270 901 Belo Horizonte, MG, Brazil
    Mycopathologia 164:27-33. 2007
    ..With azoles, lower percentages of agreement between the methodologies were observed for samples C. albicans and C. tropicalis...
  84. ncbi Successful treatment of Paecilomyces lilacinus keratitis in a patient with a history of herpes simplex virus keratitis
    Monika A Malecha
    Department of Ophthalmology, University of Missouri, Kansas City and Eye Foundation of Kansas City, Kansas City, MO 64108, USA
    Cornea 25:1240-2. 2006
    ..To report a case of Paecilomyces lilacinus keratitis, initially misdiagnosed as Penicillium sp., in a patient with a long-standing history of herpes simplex virus (HSV) keratitis...
  85. ncbi MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides
    Ramin Roohparvar
    Laboratory of Phytopathology, Wageningen University, P O Box 8025, 6700 EE Wageningen, The Netherlands
    Fungal Genet Biol 44:378-88. 2007
    ..The results indicate that MgMfs1 is a true multidrug transporter that can function as a determinant of pathogen sensitivity and resistance to fungal toxins and fungicides...
  86. ncbi Synthesis and antifungal activity of oxygenated cholesterol derivatives
    Jean Michel Brunel
    Laboratoire Synthèse et Etude de Substances Naturelles à Activités Biologiques SESNAB, IMRN INRA 1111, Faculté des Sciences et Techniques de St Jérôme, Universite Paul Cezanne, Aix Marseille III, 13397 Marseille Cedex 20, France
    Steroids 70:907-12. 2005
    ..For example, compound 2 exhibited high activities against C. albicans (CIP 1663-86) and Amphotericine B and miconazole resistant strain C. albicans (CIP 1180-79) at a concentration of 1.5 microg/mL.
  87. ncbi [Evaluation of effective treatment drugs against Acanthamoeba cyst]
    K Tahara
    Clinical Laboratory, Osaka University Hospital
    Kansenshogaku Zasshi 71:1025-30. 1997
    ..confirmed Acanthamoeba keratitis were tested in vitro for sensitivity to antimycotic agents such as fluconazole, miconazole, amphotericin-B, pimaricin, antiprotozoal agents such as pentamidine isetionate and antiseptics which could be ..
  88. ncbi Effects of cytochrome P450 inhibitors on agonist-induced Ca2+ responses and production of NO and PGI2 in vascular endothelial cells
    Kazuhiko Takeuchi
    Department of Internal Medicine III, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan
    Mol Cell Biochem 248:129-34. 2003
    ..To this end, structurally different CYP inhibitors including SKF 525A, econazole and miconazole were tested on primary cultured porcine aortic endothelial cells...
  89. ncbi Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography
    P Chiap
    Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, University of Liege, Avenue de l Hopital 1, CHU B36, B 4000 Liege, Belgium
    J Chromatogr A 948:151-61. 2002
    ..of this method development strategy, an automated procedure based on the coupling of dialysis with trace enrichment has been developed for the LC determination of antifungal agents (clotrimazole, econazole and miconazole) in plasma.
  90. ncbi [The problem of otomycosis treatment]
    M I Kurdina
    Voen Med Zh 324:49-51. 2003
  91. ncbi Comparison of in vitro activities of amphotericin, clotrimazole, econazole, miconazole, and nystatin against Fusarium oxysporum
    M N Tzatzarakis
    Department of Medicine, University of Crete, Heraklion, Greece
    J Environ Sci Health B 36:331-40. 2001
    The inhibitory activity of amphotericin B, clotrimazole, econazole, miconazole and nystatin was compared against Fusarium oxysporum f.sp. radicis-cucumerinum...
  92. pmc Pathogenic Nocardia, Rhodococcus, and related organisms are highly susceptible to imidazole antifungals
    Eric R Dabbs
    School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa
    Antimicrob Agents Chemother 47:1476-8. 2003
    ..from closely related genera, are highly susceptible to the imidazoles bifonazole, clotrimazole, econazole, and miconazole, whose MICs are </=1 micro g/ml...
  93. ncbi Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects
    H Vanden Bossche
    Steenweg op Gierle 68, B 2300 Turnhout, Belgium
    J Vet Pharmacol Ther 26:5-29. 2003
    ..This review includes chemical aspects, spectra of activity, mechanisms of action and resistance, adverse reactions and drug interactions of the antifungals in current use...
  94. ncbi Colonization of voice prostheses by albicans and non-albicans Candida species
    Tiene G M Bauters
    Department of Pharmaceutical Analysis, Ghent University, Belgium
    Laryngoscope 112:708-12. 2002
    ..e., miconazole, fluconazole, and nystatin).
  95. ncbi Antifungal drug susceptibilities of commensal Candida isolates
    Ann R Holmes
    Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, PO Box 647, Dunedin
    N Z Dent J 98:36-9. 2002
    ..broth microdilution method for susceptibility to fluconazole and to a related over-the-counter azole antifungal, miconazole. A positive correlation between susceptibility to fluconazole and to miconazole was observed...
  96. ncbi Effect of antifungal azoles on the heme detoxification system of malarial parasite
    Nguyen Tien Huy
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Biochem 131:437-44. 2002
    The antimalarial activities of some antifungal azole agents (ketoconazole, miconazole, and clotrimazole) have been known for several years, however, their antimalarial mechanism remains equivocal...
  97. ncbi [Vaginal candidiasis: etiology and sensitivity profile to antifungal agents in clinical use]
    A M Saporiti
    , , La Plata, Pcia. de Buenos Aires, Argentina
    Rev Argent Microbiol 33:217-22. 2001
    ..Fluconazole resistant C. albicans were isolated in 13.46% of the cases. Thus, further studies are required to correlate the possible role of these strains in recurrent vulvovaginal candidiasis...
  98. ncbi Modulation of human T-lymphocyte plasma membrane Ca2+ permeability by imidazole antimycotics
    E H Hornstein
    Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA
    Immunopharmacol Immunotoxicol 18:237-45. 1996
    ..Econazole, miconazole and clotrimazole dramatically inhibited the THG mediated increase in [Ca+2]i and induced an increase in [Ca+2]i ..
  99. pmc In vitro activities of 10 antifungal drugs against 508 dermatophyte strains
    B Fernandez-Torres
    Unitat de Microbiologia, Facultat de Medicina and Institut d Estudis Avançats, Universitat Rovira i Virgili, Reus, Spain
    Antimicrob Agents Chemother 45:2524-8. 2001
    ..The antifungals used were itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, terbinafine, amphotericin B, fluconazole, UR-9825, and G-1...
  100. ncbi [Antifungal susceptibility of clinically isolated Candida albicans by broth microdilution method]
    T Yamazumi
    Department of Clinical Pathology, Kinki University School of Medicine
    Kansenshogaku Zasshi 72:813-9. 1998
    ..The antifungal agents tested were fluconazole, miconazole, intraconazole, amphotericin B and flucytosine...
  101. ncbi [Present status and future prospects of azole antifungal agents in Japan]
    Katsuhiko Kamei
    Jpn J Antibiot 55:907-10. 2002

Research Grants28

  1. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..Candida albicans, Candida krusei, or Saccharomyces cerevisiae to certain drugs (including the antifungal azoles miconazole and clotrimazole, the benzimidazole albendazole, and sulfadiazine) induced a 3 to > 10-fold increase in mRNAs ..
  2. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  3. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..Interestingly, the ssk1 mutant retains the wild type levels of sensitivity to other antifungals such as miconazole and ketoconazole (imidazoles), amphotericin B, caspofungin, 5-FC, and a variety of other inhibitors such as ..
  4. THERAPY AGAINST RECALCITRANT C. albicans INFECTION
    Thomas A Dahl; Fiscal Year: 2012
    ..Our in vitro studies showed that amphotericin B or miconazole applied even at high, topical concentrations are not effective against a mature biofilm of C...
  5. Rechargeable Long-term Anticandidal Denture Materials
    Chih ko Yeh; Fiscal Year: 2013
    ..resins acted as a "rechargeable battery" to bind and then slowly release cationic antifungal drugs such as miconazole and chlorhexidine gluconate for a long period of time (weeks to months)...
  6. Rechargeable Infection-responsive Anticandidal Denture Materials
    Chih ko Yeh; Fiscal Year: 2013
    ..Antifungal drugs such as miconazole and chlorhexidine digluconate can be charged into the new denture materials and slowly released for a prolonged ..
  7. Impact of suppressive antimicrobial therapy on the vaginal microbiota and BV
    RAYMOND SCOTT MCCLELLAND; Fiscal Year: 2013
    ..randomized controlled trial to evaluate the effectiveness of PPT with intravaginal metronidazole 750mg plus miconazole 200mg vaginal suppositories versus matching placebo in reducing vaginal infections (Preventing Vaginal ..
  8. THERAPY AGAINST RECALCITRANT C. albicans INFECTION
    Thomas Dahl; Fiscal Year: 2009
    ..To test this hypothesis, we developed a screen for potentiators of miconazole, a standard therapy against vaginosis...
  9. 20-HETE IN NO-MEDIATED REGULATION OF RENAL FUNCTION
    Adebayo Oyekan; Fiscal Year: 2001
    ....
  10. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  11. Concordance Rates of Mobiluncus Among Sexual Partners
    Jane Schwebke; Fiscal Year: 2004
    ..Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission. ..
  12. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will test the hypothesis that endogenous LO metabolites are important regulators of vascular tone and blood pressure in mice. ..
  13. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    ..The drugs discovered in this research program will hopefully provide better future treatment for patients with these devastating diseases. ..
  14. LC-MS/MS for Biomedical Research
    William Campbell; Fiscal Year: 2004
    ..About 75-80% of instrument time will be available to these participants and the remaining time will be available to other investigators at the College. ..
  15. Tinidazole for the Treatment of Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2007
    ..In addition, we will measure vaginal and serum concentrations of drug during treatment and correlate with cure rates, short-term recurrence of BV, and severity of infection. ..
  16. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  17. Nitric Oxide Regulation of Adrenal Steroidogenesis
    William Campbell; Fiscal Year: 2004
    ..4) We will determine the role of endothelial NO in regulating steroidogenesis and adrenal blood flow in the in situ perfused adrenal gland and in vivo in anesthetized rats. ..
  18. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  19. Control of Trichomoniasis -A Paradigm for STD Control
    Jane Schwebke; Fiscal Year: 2006
    ..vaginalis, to examine strain differences using PFGE, and to examine the prevalence of resistance strains and their potential contribution to treatment failure. ..
  20. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  21. Therapy and Prevention for Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2006
    ..We will also utilize specimens from these prospective studies to further study the association of Mobiluncus, an organism strongly associated with BV using sensitive PCR technology. ..
  22. Structure Function Analysis of TB Pyrazinamidase
    Ying Zhang; Fiscal Year: 2005
    ..These studies will provide important information about mechanisms of PZA action and resistance and may help design new antituberculosis drugs. ..
  23. HISTATIN RECEPTORS AS DRUG TARGETS FOR ORAL CANDIDIASIS
    Mira Edgerton; Fiscal Year: 2003
    ..This award would provide her the opportunity to extend her background in yeast biology to the molecular level and apply this new expertise to studies of virulence and pathogenesis of oral and systemic candidiasis. ..
  24. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ....
  25. Host control in Coccidioidomycosis
    John Galgiani; Fiscal Year: 2008
    ..We will also analyze the phenotype, function and cytokine profiles of lymphocyte subsets that respond to antigen-pulsed DC. ..
  26. Nikkomycin Z Treatment for Coccidioidomycosis
    John Galgiani; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  27. NITRIC OXIDE AND IN VIVO BRAIN ARTERIOLAR RELAXATION
    Dale Pelligrino; Fiscal Year: 2004
    ..These studies will provide important new information regarding the mechanisms controlling a physiologic process vital to normal brain function and survival-cerebral arteriolar dilation. ..