imidazolidines

Summary

Summary: Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.

Top Publications

  1. ncbi Interaction of azimilide with neurohumoral and channel receptors
    R R Brooks
    Procter and Gamble Pharmaceuticals, 11810 E Miami River Rd, Cincinnati, OH 45252, USA
    Biochem Pharmacol 62:883-92. 2001
  2. ncbi Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circulation 114:1838-46. 2006
  3. ncbi The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice
    Soroku Yagihashi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Pathol 220:530-41. 2010
  4. pmc Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat
    Kazunori Takahashi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    PLoS ONE 7:e30134. 2012
  5. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
  6. ncbi Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    Zeina Dagher
    Harvard Medical School, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 53:2404-11. 2004
  7. ncbi Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    Satish K Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Endocr Rev 26:380-92. 2005
  8. pmc Inhibition of aldose reductase prevents colon cancer metastasis
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Carcinogenesis 32:1259-67. 2011
  9. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
  10. ncbi Deletion of aldose reductase leads to protection against cerebral ischemic injury
    Amy C Y Lo
    Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    J Cereb Blood Flow Metab 27:1496-509. 2007

Detail Information

Publications192 found, 100 shown here

  1. ncbi Interaction of azimilide with neurohumoral and channel receptors
    R R Brooks
    Procter and Gamble Pharmaceuticals, 11810 E Miami River Rd, Cincinnati, OH 45252, USA
    Biochem Pharmacol 62:883-92. 2001
    ..14 microM for carbachol). Azimilide's receptor interactions occur at concentrations from one to forty times those required to block cardiac delayed-rectifier channels but could contribute to the efficacy and safety of the drug...
  2. ncbi Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circulation 114:1838-46. 2006
    ..Postreceptor signaling events that lead to stress responses and cytokine production are sensitive to redox changes and products of lipid peroxidation...
  3. ncbi The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice
    Soroku Yagihashi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Pathol 220:530-41. 2010
    ..Thus, these findings suggest that the polyol pathway is implicated in AKI caused by ischaemic limb injury and that AR may be a potential therapeutic target for this condition...
  4. pmc Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat
    Kazunori Takahashi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    PLoS ONE 7:e30134. 2012
    ..Aldose reductase (AR) inhibitor is recently found to suppress lipopolysaccharide (LPS)-induced cardiac failure and its lethality. We studied the effects of AR inhibitor on LPS-induced acute kidney injury and its mechanism...
  5. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..In conclusion, increased AR activity contributes to retinal oxidative stress and VEGF protein overexpression in early diabetes. The findings justify the rationale for evaluation of fidarestat on diabetic retinopathy...
  6. ncbi Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    Zeina Dagher
    Harvard Medical School, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Diabetes 53:2404-11. 2004
    ..Excess aldose reductase activity can be a mechanism for human diabetic retinopathy...
  7. ncbi Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    Satish K Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Endocr Rev 26:380-92. 2005
    ....
  8. pmc Inhibition of aldose reductase prevents colon cancer metastasis
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Carcinogenesis 32:1259-67. 2011
    ..Thus, our results indicate that AR regulates cancer cell adhesion, invasion and migration events which initiate metastasis and therefore, AR inhibition could be a novel therapeutic approach for the prevention of colon cancer metastasis...
  9. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..These findings reveal the new beneficial properties of fidarestat, thus further justifying the ongoing clinical trials of this specific, potent, and low-toxic ARI...
  10. ncbi Deletion of aldose reductase leads to protection against cerebral ischemic injury
    Amy C Y Lo
    Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    J Cereb Blood Flow Metab 27:1496-509. 2007
    ....
  11. ncbi A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography
    M Oka
    Rational Drug Design Laboratories, 4 1 1, Misato, Matsukawa machi, Fukushima 960 1242, Japan
    J Med Chem 43:2479-83. 2000
    ..Explanations for the differences between the observed activities of fidarestat and its stereoisomer 2 were suggested by computer modeling...
  12. ncbi Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:2321-6. 2007
    ..The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE inhibition...
  13. ncbi A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    Veronica Asnaghi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 52:506-11. 2003
    ..These findings have implications for how to evaluate the role of the polyol pathway in diabetic retinopathy...
  14. ncbi An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 16:123-5. 2002
    ..In conclusion, treatment with adequate doses of ARIs (that is, doses that completely inhibit increased sorbitol pathway activity) is an effective approach for reversal of, at least, early diabetic neuropathy...
  15. pmc Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
    Aramati B M Reddy
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Cytokine 48:170-6. 2009
    ..Our aim is to investigate the effect of AR inhibitors on the prevention of inflammatory cytokines in the cecum ligation and puncture (CLP) model of polymicrobial sepsis which closely mimics the sepsis syndrome in humans...
  16. pmc Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4
    Sebastien Fortin
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, CHUQ, Hôpital Saint François d Assise, Québec, Québec, Canada
    J Med Chem 54:4559-80. 2011
    ..PIB-SOs were subjected to CoMFA and CoMSIA analyses to establish quantitative structure-activity relationships...
  17. ncbi Biological and immunological activity of new imidazolidines against adult worms of Schistosoma mansoni
    Juliana Kelle de Andrade Lemoine Neves
    Laboratório de Planejamento e Síntese de Fármacos LPSF do Departamento de Antibióticos UFPE, Recife, Pernambuco, Brazil
    Parasitol Res 107:531-8. 2010
    ..RZS-2) and LPSF/5-(4-fluoride-benzylidene-3-(4-nitrebenzyl)-4-thioxo-imidazolidin-2-one (RZS-5) imidazolidines, against adult worms of Schistosoma mansoni...
  18. ncbi Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury
    Alvin K H Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Exp Eye Res 85:608-16. 2007
    ..Therefore, AR inhibition should be considered for the treatment of retinal ischemic injury often observed in diabetic patients...
  19. ncbi Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Diabetes Care 24:1776-82. 2001
    ..The purpose of this study was to evaluate the efficacy of fidarestat, a novel aldose reductase (AR) inhibitor, in a double-blind placebo controlled study in patients with type 1 and type 2 diabetes and associated peripheral neuropathy...
  20. ncbi Important role of nitric oxide in the effect of angiotensin-converting enzyme inhibitor imidapril on vascular injury
    Rui Chen
    Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Hypertension 42:542-7. 2003
    ..These results indicate that not only blockade of angiotensin II production but also activation of the bradykinin-NO system plays an important role in the beneficial effects of imidapril on vascular remodeling...
  21. ncbi [The inhibitory effect of aldose reductase inhibitor for proliferation in the lens epithelial cells of rat sugar cataract]
    Soichi Morikubo
    Department of Ophthalmology, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka machi, Yoshida gun, Fukui 910 1193, Japan
    Nihon Ganka Gakkai Zasshi 107:565-70. 2003
    ..To evaluate the inhibitory effect of aldose reductase inhibitor (ARI) for the accumulation of sugar alcohol and the enhanced proliferation of lens epithelial cells of rats fed a galactose diet...
  22. ncbi Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats
    Noriaki Kato
    Central Research Laboratory, Sanwa Kagaku Kenkyusho Co, Ltd, 363 Shiosaki, Hokusei, Mie 511 0406, Inabe, Japan
    J Diabetes Complications 17:374-9. 2003
    ..These results suggest that fidarestat, by virtue of its long-term correction of the accelerated polyol pathway, has a potential role in preventing the progression of diabetic retinopathy...
  23. ncbi Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide
    Karsten Knobloch
    DG Cardiovascular Diseases, Aventis Parma, Industriepark Hochst, Frankfurt am Main, Germany
    Naunyn Schmiedebergs Arch Pharmacol 366:482-7. 2002
    ..In contrast to selective I(Kr) blockade, I(Kur) blockade inhibited left atrial vulnerability and had no effect on the QT-interval. Thus, blockade of I(Kur) seems to be a promising atrial selective antiarrhythmic concept...
  24. ncbi Pure class III agents for prevention of sudden cardiac death
    Craig M Pratt
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Cardiovasc Electrophysiol 14:S82-6. 2003
    ..These trials play pivotal roles for regulatory approval of these drugs for use in atrial fibrillation...
  25. ncbi Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trials
    Stuart J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am Heart J 146:489-93. 2003
    ..This paper examines the data collected during those studies regarding the symptoms reported by patients at the time of AF recurrence..
  26. ncbi Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues
    Deborah L Wolbrette
    Department of Medicine, The Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Cardiol 91:39D-44D. 2003
    ....
  27. ncbi Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilide
    Richard L Page
    Cardiovascular Division, Clinical Cardiac Electrophysiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, USA
    Circulation 107:1141-5. 2003
    ....
  28. ncbi [Drug therapy of ventricular arrhythmias - a contemporary perspective]
    G C Grönefeld
    Johann Wolfgang Goethe Universitat, Medizinische Klinik IV, Frankfurt am Main, Germany
    Dtsch Med Wochenschr 127:2280-4. 2002
  29. pmc Effect of severe renal impairment on the pharmacokinetics of azimilide following single dose oral administration
    Alfred E Corey
    Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040 9462, USA
    Br J Clin Pharmacol 54:449-52. 2002
    ..To assess the influence of severe renal impairment on azimilide pharmacokinetics...
  30. ncbi Angiotensin II and oxidative stress in Dahl Salt-sensitive rat with heart failure
    Akihiro Tojo
    Division of Nephrology and Endocrinology, Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    Hypertension 40:834-9. 2002
    ..In conclusion, DSHF rats showed increased oxidative stress in the kidney via NAD(P)H oxidase. Blockade of local angiotensin II with subpressor dose of imidapril inhibited NAD(P)H oxidase and prevented renal damage...
  31. ncbi The effect of isoproterenol on the class III effect of azimilide in humans
    Paul Dorian
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    J Cardiovasc Pharmacol Ther 7:211-7. 2002
    ..Azimilide is an investigational class III antiarrhythmic agent that blocks both IKr and IKs...
  32. ncbi Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    FASEB J 17:315-7. 2003
    ..These observations could provide new insights into the pathophysiology of diabetes and the role of aberrant glucose metabolism in apoptotic cell death...
  33. ncbi Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs
    Michael Cusick
    National Eye Institute, National Institutes of Health, and Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
    Arch Ophthalmol 121:1745-51. 2003
    ....
  34. ncbi High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor
    Ossama El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia
    J Med Chem 47:4530-7. 2004
    ....
  35. ncbi Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs
    Karsten Knobloch
    DG Cardiovascular Diseases, Aventis Pharma, Frankfurt am Main, Germany
    Med Sci Monit 10:BR221-8. 2004
    ....
  36. ncbi Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase
    Sally A Price
    Division of Neuroscience, School of Biological Sciences, University of Manchester, Stopford Building 1 124, Oxford Road, Manchester M13 9PT, UK
    Diabetes 53:1851-6. 2004
    ..Insulin and aldose reductase inhibitors can prevent excess polyol pathway flux, and hence these agents may prevent NCV deficits by preventing p38 MAP kinase activation...
  37. ncbi Diverse effects of long-term treatment with imidapril and irbesartan on cell growth signal, apoptosis and collagen type I expression in the left ventricle of spontaneously hypertensive rats
    Jin Ming Wang
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, People s Republic of China
    Life Sci 75:407-20. 2004
    ..Irbesartan is more effective in regressing the homeostasis between ERK-1 and MKP-1, however imidapril is superior in suppressing apoptosis and collagen synthesis in cardiac tissue...
  38. ncbi Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
    Ossama El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Parkville Campus, Parkville, Victoria, Australia
    Proteins 55:805-13. 2004
    ..These observations suggest a mechanism in which Fidarestat is bound protonated and becomes negatively charged by donating the proton to His110, which may have important implications on drug design...
  39. ncbi The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial
    Craig M Pratt
    The Methodist DeBakey Heart Center and Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 43:1211-6. 2004
    ....
  40. ncbi Influence of azimilide on CYP2C19-mediated metabolism
    Mohamed El Mouelhi
    Procter and Gamble Pharmaceuticals, Mason, OH 45040 9462, USA
    J Clin Pharmacol 44:373-8. 2004
    ....
  41. ncbi Effect of imidapril, an angiotensin-converting enzyme inhibitor, on fructose-induced insulin resistance in rats
    Tsuneyuki Oda
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
    Endocr J 51:69-74. 2004
    ....
  42. ncbi Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification
    A John Camm
    Department of Cardiology, St George s Hospital, London, UK
    Circulation 109:990-6. 2004
    ..Azimilide, a novel class III antiarrhythmic drug, was investigated for its effects on mortality in patients with depressed LVF after recent MI and in a subpopulation of patients with low HRV...
  43. ncbi Trials of new antiarrhythmic drugs for maintenance of sinus rhythm in patients with atrial fibrillation
    Steven Singh
    Veterans Affairs Center, Washington, USA
    J Interv Card Electrophysiol 10:71-6. 2004
    ..Tedisamil is a complex class 3 agent, blocking multiple channels. Piboserod is a selective 5-HT receptor antagonist that is being investigated in clinical trials...
  44. ncbi Azimilide for atrial fibrillation: clinical trial results and implications
    Edward L C Pritchett
    Department of Medicine, Division of Clinical Pharmacology, Duke University Medical Center, Durham, North Carolina, USA
    Card Electrophysiol Rev 7:215-9. 2003
    ..Infrequent cases of torsade de pointes and severe neutropenia were reported in patients taking azimilide. Azimilide is an investigational antiarrhythmic drug that has shown efficacy in patients with atrial fibrillation...
  45. ncbi Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells
    Weiguo Li
    Division of Metabolic Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 314:370-6. 2004
    ..The results suggest that the polyol pathway may play a substantial role in SMC hyperplasia under hyperglycemic condition in part by affecting HB-EGF mRNA expression via the production of carbonyl compounds and oxidative stress...
  46. ncbi [Progress in the clinical use of anti-arrhythmic drugs (I)]
    Wan zhen Li
    Zhonghua Er Ke Za Zhi 41:735-7. 2003
  47. ncbi Azimilide decreases recurrent ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators
    Igor Singer
    University of Louisville, Division of Cardiology, Louisville, Kentucky, USA
    J Am Coll Cardiol 43:39-43. 2004
    ..This study evaluated the effects of azimilide dihydrochloride (AZ) on anti-tachycardia pacing (ATP) and shock-terminated events in patients with implantable cardioverter defibrillators (ICDs)...
  48. ncbi Oral class III antiarrhythmics: what is new?
    Mazhar H Khan
    Department of Medicine, Pennsylvania State University, College of Medicine, The Milton S Hershey Medical Center, Hershey 17033, USA
    Curr Opin Cardiol 19:47-51. 2004
    ..This review describes the latest developments in the clinical usage of class III antiarrhythmics. It also discusses some new studies providing insight into the mechanism of action of these drugs...
  49. pmc Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells
    S Srivastava
    Experimental Research Laboratories, Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Atherosclerosis 158:339-50. 2001
    ..These metabolic pathways may be the key regulators of the vascular effects of HNE and oxidized LDL...
  50. ncbi Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes
    Deepak Chandra
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
    Diabetes 51:3095-101. 2002
    ..Thus, increasing NO availability may be a useful strategy for inhibiting the polyol pathway and preventing the development of diabetes complications...
  51. ncbi Oxidized aldose reductase: in vivo factor not in vitro artifact
    C E Grimshaw
    Whittier Diabetes Program, Department of Medicine, University of California at San Diego, La Jolla, 92093 0983, USA
    Arch Biochem Biophys 327:89-97. 1996
    ....
  52. ncbi Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves?
    A Colciago
    Department of Endocrinology, University of Milano, Italy
    Exp Clin Endocrinol Diabetes 110:22-6. 2002
    ..We conclude that hyperglycemia or the administration of the AR inhibitors do not affect 3alpha-HSD activity in peripheral nerves and therefore do not reduce the formation of steroid metabolites possibly endowed with neurotrophic action...
  53. ncbi Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillation
    S J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 88:974-9. 2001
    ..9% of patients receiving either of the 2 effective doses. Thus, doses of azimilide <100 mg/day are not effective for control of AF, whereas doses of 100 and 125 mg/day are effective with an acceptable risk of serious toxicity...
  54. ncbi A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide
    L Phillips
    Cognigen Corporation, Williamsville, NY, USA
    Clin Pharmacol Ther 70:370-83. 2001
    ..The relationship between azimilide concentration and change in QTc is primarily dependent on serum potassium...
  55. ncbi Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction
    H Schmitt
    Department of Pharmacology, Center of Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Cardiovasc Electrophysiol 12:1025-33. 2001
    ..CONCLUSION: Azimilide has antiarrhythmic effects to prevent reentry causing SVT and VF in a canine infarct model...
  56. ncbi Efficacy of azimilide and dofetilide in the dog right atrial enlargement model of atrial flutter
    M Restivo
    Cardiology Division, State University of New York Health Sciences Center at Brooklyn and Brooklyn Veterans Administration Medical Center, USA
    J Cardiovasc Electrophysiol 12:1018-24. 2001
    ..Efficacy relied on a similar mechanism of differentially prolonged refractoriness in the slow conduction component of the reentrant circuit where drug-induced termination occurred...
  57. ncbi Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes
    H Sobajima
    Department of Internal Medicine, Ogaki Municipal Hospital, Gifu, Japan
    Pharmacology 62:193-9. 2001
    ..These results suggest that fidarestat potently inhibits the increase in sorbitol pathway flux in diabetic patients independent of various factors and that erythrocyte sorbitol is useful for its estimation...
  58. ncbi Effects of imidapril on endothelin-1 and ACE gene expression in failing hearts of salt-sensitive hypertensive rats
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 13:1088-96. 2000
    ....
  59. ncbi Effect of imidapril on myocardial remodeling in L-NAME-induced hypertensive rats is associated with gene expression of NOS and ACE mRNA
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 13:199-207. 2000
    ..Myocardial remodeling in L-NAME-induced hypertensive rats was significantly ameliorated by a subdepressor dose of imidapril, which may be due to an increase in local eNOS mRNA expression and a decrease in angiotensin II in the LV...
  60. ncbi Antihypertensive agents prevent nephrosclerosis and left ventricular hypertrophy induced in rats by prolonged inhibition of nitric oxide synthesis
    N Akuzawa
    Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am J Hypertens 11:697-707. 1998
    ....
  61. ncbi Regulation of vascular smooth muscle cell growth by aldose reductase
    A Bhatnagar
    Division of Cardiology, Department of Medicine, Jewish Cardiovascular Research Center, University of Louisville, 500 South Floyd Street, 40202, Louisville, KY, USA
    Chem Biol Interact 130:627-36. 2001
    ..Together, these observations suggest that, in vascular smooth muscle cells (VSMC), AR is a growth-responsive gene product and that inhibition of AR prevents VSMC growth and decreases intimal hyperplasia and restenosis...
  62. ncbi A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil
    A Urzhumtsev
    UPR de Biologie Structurale 9004 IGMBC CNRS INSERM ULP 1 rue Laurent Fries, B P 163, 67404, Illkirch, France
    Structure 5:601-12. 1997
    ..The inhibitor zopolrestat binds to this anionic site, and in the hydrophobic cleft, after a change of conformation which opens a 'specificity' pocket...
  63. ncbi Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones
    G Bruno
    Dipartimento Ch Inorg, Chim Anal e Ch Fis, Facoltà Scienze MMFFNN, Universita di Messina, Salita Sperone 31, 98166, Messina, Italy
    Bioorg Med Chem 10:1077-84. 2002
    ....
  64. pmc Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    Lawrence J Coppey
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52246, USA
    Int J Exp Diabetes Res 3:21-36. 2002
    ..These studies suggest that sorbinil treatment may be more effective in preventing neural dysfunction in diabetes than either aminoguanidine or myo-inositol...
  65. ncbi Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 277:32063-70. 2002
    ..Collectively, these data suggest that inhibition of NF-kappa B may be a significant cause of the antimitogenic effects of AR inhibition and that this may be related to disruption of PKC-associated signaling in the AR-inhibited cells...
  66. ncbi ["Diabetic autonomic neuropathy" series. Epidemiology, pathogenesis, basic therapy and prognosis]
    D Luft
    Abt Innere Medizin IV, Med Universitäts und Poliklinik, Eberhard Karls Universitat, Tubingen
    MMW Fortschr Med 144:47-50. 2002
  67. ncbi Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients
    Tomoichiro Asano
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113, Tokyo, Japan
    J Diabetes Complications 16:133-8. 2002
    ..Further studies are needed to clarify how much the occurrence and progression of diabetic neuropathy are inhibited by normalizing sorbitol elevation with fidarestat treatment...
  68. ncbi Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-response
    Richard L Page
    Department of Medicine, Cardiovascular Division, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Tex 75390 9047, USA
    Am Heart J 143:643-9. 2002
    ..Its effect on paroxysmal supraventricular tachycardia (PSVT) has not been reported...
  69. ncbi New antiarrhythmic drugs for the treatment of atrial fibrillation
    Antonio Castro
    Department of Heart Disease, S Filippo Neri Hospital, Rome, Italy
    Pacing Clin Electrophysiol 25:249-59. 2002
  70. ncbi Tissue Angiotensin-converting enzyme activity plays an important role in pressure overload-induced cardiac fibrosis in rats
    Yukie Kurosawa
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 2 2 50 Kawagishi, Toda shi, Saitama 335 8505, Japan
    J Cardiovasc Pharmacol 39:600-9. 2002
    ..These results suggest that the increased local ACE expression contributes to the development of pressure overload-induced cardiac fibrosis but is not responsible for hypertrophy in rats...
  71. ncbi Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)formate
    Krzysztof Sztanke
    Department of Synthesis and Technology of Drugs, Professor Feliks Skubiszewski Medical University, Lublin, Poland
    Eur J Med Chem 41:539-47. 2006
    ..The title compounds were obtained by two independent synthesis methods from 1-aryl-2-hydrazono-imidazolidines (1-aryl-2-hydrazino-imidazolines) (1-6) by cyclocondensation reaction with diethyl 2-(hydroxyimino)malonate (A)..
  72. ncbi 1H-nuclear magnetic resonance determination of the enantiomeric purity of aliphatic primary amines, beta-aminoalcohols, beta-diamines and alpha-amino-acids with 1R-(-)-myrtenal: scope and limitations
    Francois Dufrasne
    Laboratoire de Chimie Pharmaceutique Organique, Institut de Pharmacie, Universite Libre de Bruxelles, CP 205 5, Campus Plaine, B 1050, Brussels, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 59:1239-45. 2003
    ..imines were completely formed after 12 h and analysed by 1H-NMR except for N-methyl beta-diamines for which imidazolidines were obtained...
  73. ncbi A stereoselective entry into functionalized 1,2-diamines by zinc-mediated homologation of alpha-aminoacids
    Cam Thuy Hoang
    Laboratoire de Chimie des Procedes et Substances Naturelles, Institut de Chimie Moléculaire et des Matériaux d Orsay UMR CNRS 8182, Batiment 410, Université de Paris Sud 11, F 91405 Orsay, France
    Org Lett 9:2521-4. 2007
    A general, stereoselective synthesis of 4,5-disubstituted imidazolidines-2-ones from alpha-aminoacids has been developed: the key steps are a Blaise reaction of bromoacetate on alpha-aminonitriles and further reduction...
  74. ncbi Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes
    P Vigne
    Centre de Biochimie du CNRS, Nice, France
    Eur J Pharmacol 160:295-8. 1989
    ..These binding sites may be the normal target of a series of imidazolidines derivatives (guanabenz, guanochlor, guanoxan), which are known for their antihypertensive properties.
  75. ncbi Synthesis of 2,3,5,6-tetrahydro-3H-imidazo[2,1-b] [1,3,5]benzotriazepines and their oxidative ring contraction into 1-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzimidazoles
    Franciszek Saczewski
    Department of Chemical Technology of Drugs, Medical University of Gdansk, 80 416 Gdansk, Poland
    Farmaco 60:127-34. 2005
    ..1,3,5]benzotriazepine derivatives 3a-g were performed by reacting 2-(2-aminoarylimino)imidazolidines 1a-b with corresponding aryl aldehydes...
  76. ncbi Dynamic kinetic asymmetric cycloadditions of isocyanates to vinylaziridines
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 125:11836-7. 2003
    ..The products were easily reduced almost quantitatively to the sensitive imidazolidines which can be readily hydrolyzed to the vicinal diamines...
  77. ncbi Diamine-free lithiation-trapping of N-Boc heterocycles using s-BuLi in THF
    Graeme Barker
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    Org Lett 12:4176-9. 2010
    ..Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered a range of functionalized pyrrolidines, imidazolidines, and piperazines in 43-83% yield.
  78. ncbi The vinylfluoro group as an acetonyl cation equivalent: stereoselective synthesis of 6-substituted 4-hydroxy pipecolic acid derivatives
    Nirupam Purkayastha
    Organisch Chemisches Institut, Universitat Munster, Corrensstrasse 40, D 48149 Munster, Germany
    J Org Chem 75:222-5. 2010
    ..The pipecolic acid derivative 5 produced in this way is further used to synthesize (2R,4R,6S)-6-tert-butyl-4-hydroxypiperidine-2-carboxylic acid 9...
  79. ncbi Syncope caused by nonsteroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors
    C Kurata
    Department of Medicine III, Hamamatsu University School of Medicine, Japan
    Jpn Circ J 63:1002-3. 1999
    ..This case warns physicians that the combination of NSAID and ACEI can produce serious side effects in aged patients who frequently suffer from hypertension, diabetes mellitus, ischemic heart disease, and degenerative joint disease...
  80. ncbi Laser flash photolysis and CIDNP studies of steric effects on coupling rate constants of imidazolidine nitroxide with carbon-centered radicals, methyl isobutyrate-2-yl and tert-butyl propionate-2-yl
    Dmitry Zubenko
    International Tomography Center SB RAS, Novosibirsk, Russia, Institute of Organic Chemistry SB RAS, Novosibirsk, Russia
    J Org Chem 71:6044-52. 2006
    ..52sigmaL,n + 0.47Es,n + 10.62. Hence, kc decreases with the increasing steric demand and increases with the increasing electron-withdrawing character of the substituents on the nitroxide...
  81. ncbi Pharmacokinetics and pharmacodynamics of a sustained-release biodegradable pellet containing imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats
    K Yamanaka
    Analytical Research Laboratory, Tanabe Seiyaku, Osaka, Japan
    J Pharm Biomed Anal 15:1861-6. 1997
    ....
  82. ncbi Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs
    Dong Liu
    Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Pharmazie 66:888-93. 2011
    ..Thus, the knowledge about the characteristic and site-specific expression of CES1 and CES2 in rat intestine will help to predict the oral bioavailability of ester prodrugs...
  83. pmc Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression
    Ashish Saxena
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States
    Eur J Cancer 49:3311-9. 2013
    ....
  84. ncbi Mass spectrometric identification of 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid during oxidation of 8-oxoguanosine by peroxynitrite and KHSO5/CoCl2
    Jacquin C Niles
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56 738A, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 17:1501-9. 2004
    ..The mechanism of HICA formation is rationalized by water attack at C5 of a quininoid intermediate...
  85. ncbi N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
    Stephane Raeppel
    Department of Medicinal Chemistry, MethylGene Inc, 7220 rue Frederick Banting, Montreal, QC, Canada H4S 2A1
    Bioorg Med Chem Lett 19:1323-8. 2009
    ..The compounds were potent against these two enzymes with IC(50) values in the low nanomolar range in vitro, possessed favorable pharmacokinetic profiles and showed high efficacy in vivo in several human tumor xenograft models in mice...
  86. pmc Stimulation of erythropoiesis by the non-steroidal anti-androgen nilutamide in men with prostate cancer: evidence for an agonistic effect?
    A Decensi
    Department of Medical Oncology II, National Institute for Cancer Research, Genoa, Italy
    Br J Cancer 69:617-9. 1994
    ..Ongoing randomised trials should address this issue...
  87. ncbi Imidapril: will fewer adverse events translate into better long-term outcomes?
    Tom Richart
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Drugs 67:1379-82. 2007
  88. ncbi Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex
    Tatiana Petrova
    Laboratoire de Génomique et de Biologie Structurales, UMR 7104 du CNRS, IGBMC, 1 rue Laurent Fries, B P 10142, 67404 Illkirch, France
    J Med Chem 48:5659-65. 2005
    ....
  89. ncbi Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors
    Shanthi Nagarajan
    Neuro Medicine Center, Life Sciences Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130 650, Republic of Korea
    J Med Chem 55:2561-73. 2012
    ..This is the first successful reported procedure for the identification of Eg5 inhibitors via receptor-ligand interaction-based virtual screening...
  90. ncbi Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9
    Daisuke Yamamoto
    Biomedical Computation Center, Osaka Medical College, 2 7 Daigakuchou, Takatsuki, Osaka 569 8686, Japan
    J Mol Cell Cardiol 43:670-6. 2007
    ..These findings show that imidapril inhibits MMP-9 directly like lisinopril and its hydrophobic interactions with the S1 site of MMP-9 would be important for enhancing inhibitory activity...
  91. ncbi The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents
    Congrong Lin
    Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA
    Cardiology 108:18-27. 2007
    ..We evaluated the influence of increased extracellular potassium concentration [K(+)](e) on IKr inhibition by amiodarone, azimilide, dofetilide, quinidine and sotalol...
  92. ncbi Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells
    Agnieszka Pladzyk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 47:5395-403. 2006
    ....
  93. pmc Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor
    Donghua Yin
    Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Pharmacol 63:211-23. 2003
    ..Also, these studies uncovered or confirmed numerous important SARs governing AR binding and functional properties by nonsteroidal molecules, which would be valuable in the future structural optimization of SARMs...
  94. ncbi Is there any association between imidapril hydrochloride stability profile under dry air conditions and cancer initiation?
    Katarzyna Regulska
    Greater Poland Oncology Center, 15th Garbary Street, 61 866 Poznan, Poland Poznań University of Medical Sciences, Department of Pharmaceutical Chemistry, 6th Grunwaldzka Street, 60 780 Poznan, Poland Electronic address
    Int J Pharm 456:332-9. 2013
    ..16-5.0mg/mL) of DKP in the presence and absence of metabolic activation system. No mutagenic effect was observed confirming that the presence of DKP in IMD final dosage form has no impact on cancer initiation...
  95. ncbi Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator
    Paul Dorian
    Division of Cardiology, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    Circulation 110:3646-54. 2004
    ....
  96. ncbi Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase
    Mehdi Rajabi
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Eur J Med Chem 46:1165-71. 2011
    ..Molecular modelling suggests that this ligand, when complexed with closed-cleft human TP, would have the phenylalkyl group in the active site region normally occupied by a thymine-containing structure...
  97. pmc Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
    Guijia He
    Department of Chemistry, Wichita State University, 206 McKinley Hall, 1845 Fairmount, Wichita, Kansas 67260, USA
    Eur J Med Chem 45:4280-7. 2010
    ..These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE...
  98. ncbi Suppressive effects of imidapril on Th1- and Th2-related chemokines in monocytes
    Ming Kai Tsai
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    J Investig Med 59:1141-6. 2011
    ..However, the modulatory effects and the mechanisms of ACEIs on TNF-α and Th1- and Th2-related chemokines in monocytes remain poorly defined...
  99. pmc Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 26:135-42. 2010
    ..The results identify AR as an important therapeutic target for diseases involving IR injury, and provide the rationale for development of fidarestat and other AR inhibitors...
  100. ncbi Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels
    De Li Dong
    Department of Pharmacology, Harbin Medical University, Heilongjiang Key Laboratory of Bio pharmaceutical engineering, Harbin, 150086, P R China
    Basic Clin Pharmacol Toxicol 94:209-12. 2004
    ..5 was similar to that under pH 7.5 (n=6). Acidification markedly potentiated dofetilide blockade of the HERG channels but weakened the inhibitory effects of quinidine and azimilide...
  101. pmc The 1-carbamoyl-2-oxo-4,5-dihydroxyimidazolidine component of ROS-induced DNA damage in white blood cells
    Herbert Iijima
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Radiat Res 174:101-6. 2010
    ..The background level of the 1-carbamoyl-2-oxo-4,5-dihydroxyimidazolidine modification of cytosine was found to be larger than the levels of the formamide and thymine glycol base modifications...

Research Grants24

  1. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  2. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  3. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  4. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2008
    ..qeocities.com/bernardrosner/channina.html). [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Medication Use, Comorbidity and Outcomes in Aging populations
    Robert Glynn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  7. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2006
    ....
  8. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    ..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
  9. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
    ..The results of this work may lead to new strategies for VTE preventio. ..
  10. Medication Use, Cormobidity and Outcomes in Aging Populations
    Robert J Glynn; Fiscal Year: 2010
    ..These studies are intended to advance methodologic strategies for evaluation of drug use and its effects in older people and to lay the foundation for interventions to improve prescribing in this population. ..
  11. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  12. Neutralizing Compounds for Viral Hemorrhagic Fever
    Richard Larson; Fiscal Year: 2003
    ..abstract_text> ..
  13. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS-DCC
    Robert Glynn; Fiscal Year: 2002
    ..Events will be assessed by yearly visits and bi-monthly questionnaires at the time of the INR monitoring. ..
  14. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 2002
    ..The PI results should show whether inclusions of antioxidants as part of ARI therapy in diabetes would be useful to counteract and decrease in cellular antioxidant defense due to inhibition of AR. ..
  15. Multiplex Screening for ABC Transporter Inhibitors
    Richard Larson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    BARRY SNIDER; Fiscal Year: 2009
    ..In the course of these studies new methods will be developed that are of general utility for preparing drugs more economically. ..
  17. ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2001
    ....
  18. Amelioration of Uveitis by Aldose reductase Inhibition
    KOTA VENKATA RAMANA; Fiscal Year: 2010
    ..abstract_text> ..
  19. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
  20. Microenvironmental mechanisms of leukemia cell survival
    Richard Larson; Fiscal Year: 2009
    ..In addition, we will share this data with Dr. Tom Look at the Dana Farber Cancer Center in order to correlate his genetic findings in his T-ALL Zebra fish model with our human studies. ..
  21. Inflammatory cytokines in diabetic retinopathy
    Chiara Gerhardinger; Fiscal Year: 2009
    ..Recombinant IL-1ra or other anti-IL-1[unreadable] drugs could become powerful tools to prevent retinopathy - with possible applications to other diabetic complications with an inflammatory component such as atherosclerosis. ..
  22. Neutralizing Compounds for Viral Hemorrhagic Fever
    Richard Larson; Fiscal Year: 2005
    ....
  23. SPECIES SUSCEPTIBILITY TO DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2002
    ....