Genomes and Genes
Summary: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 188.8.131.52.
Publications299 found, 100 shown here
- Updated definitions of healthy ranges for serum alanine aminotransferase levelsDaniele Prati
Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
Ann Intern Med 137:1-10. 2002..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
- Determinants of viral clearance and persistence during acute hepatitis C virus infectionR Thimme
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
J Exp Med 194:1395-406. 2001....
- The current state of serum biomarkers of hepatotoxicityJosef Ozer
Safety Assessment, Merck Research Laboratories, West Point, PA, USA
Toxicology 245:194-205. 2008..Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in early clinical trials...
- Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular diseaseRoger K Schindhelm
Department of Endocrinology Diabetes Centre, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
Diabetes Metab Res Rev 22:437-43. 2006..In addition, treatment strategies to ameliorate NAFLD and the associated risks are discussed...
- Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferonAdrian M Di Bisceglie
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
N Engl J Med 359:2429-41. 2008..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
- Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and futureAnna Wieckowska
Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Hepatology 46:582-9. 2007..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
- The prevalence and etiology of elevated aminotransferase levels in the United StatesJeanne M Clark
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Gastroenterol 98:960-7. 2003..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
- How can we enhance the performance of liver stiffness measurement using FibroScan in diagnosing liver cirrhosis in patients with chronic hepatitis B?Seung Up Kim
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
J Clin Gastroenterol 44:66-71. 2010....
- Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT valuesPouneh Mofrad
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Hepatology 37:1286-92. 2003....
- Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United StatesConstance E Ruhl
Social and Scientific Systems, Inc, 8757 Georgia Avenue, 12th Floor, Silver Spring, MD 20910, USA
Gastroenterology 124:71-9. 2003..We examined whether central adiposity and metabolic markers explain the association of body mass index (BMI as kg/m(2)) with abnormal serum alanine aminotransferase (ALT) activity in a national, population-based study...
- High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetesBarbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1889-95. 2002..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
- Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn StudyRoger K Schindhelm
Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
Atherosclerosis 191:391-6. 2007..Further studies should confirm these findings and elucidate the pathophysiological mechanisms...
- Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA levelChien Jen Chen
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
JAMA 295:65-73. 2006..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
- A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapyM F Yuen
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Gut 52:416-9. 2003..In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients...
- Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis CMaribel Rodriguez-Torres
Fundacion de Investigacion de Diego, San Juan, Puerto Rico
N Engl J Med 360:257-67. 2009..We evaluated the effect of Latino ethnic background on the response to treatment with peginterferon alfa-2a and ribavirin in patients infected with HCV genotype 1 who had not been treated previously...
- Liver enzyme alteration: a guide for cliniciansEdoardo G Giannini
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
CMAJ 172:367-79. 2005....
- Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histologyJae Keun Lee
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Hepatology 51:1577-83. 2010..Age, BMI, and/or other metabolic parameters significantly affect ALT levels, even in subjects with normal livers...
- Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injuryAyano Itoh
Graduate School of Pharmaceutical Sciences, Osaka University
Biol Pharm Bull 32:1215-9. 2009..Together, these findings indicate that the phenolic compounds in L.E.M. are hepatoprotective through their suppression of immune-mediated liver inflammation...
- Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminasesB Coco
UO Gastroenterologia ed Epatologia Ospedaliera, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
J Viral Hepat 14:360-9. 2007....
- Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicityDaniel J Antoine
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
J Hepatol 56:1070-9. 2012..The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity...
- Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: virological breakthrough is also dependent on adherence to medicationHidehiro Kamezaki
Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Scand J Gastroenterol 46:1111-7. 2011....
- Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descentS Romeo
Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
Int J Obes (Lond) 34:190-4. 2010..Intriguingly, initial findings in cohorts with a mean body mass index (BMI) of 30 kg m(-2) also suggested that it is associated with elevated liver enzymes but not with insulin resistance and dyslipidaemia...
- Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver diseaseYoosoo Chang
Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Clin Chem 53:686-92. 2007..We performed a prospective study to examine the association between ALT within its reference interval and risk for subsequent development of NAFLD...
- Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in miceRun Zhi Zhu
Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
World J Gastroenterol 16:2771-9. 2010..To evaluate the effects of positive regulation of recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury in mice induced by carbon tetrachloride (CCl(4))...
- A novel liver stiffness measurement-based prediction model for cirrhosis in hepatitis B patientsBeom Kyung Kim
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Liver Int 30:1073-81. 2010..We developed a new LSM-based prediction model for cirrhosis and estimated the thresholds for different ALT levels...
- SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver diseaseJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103 8450, USA
Gastroenterology 138:1357-64, 1364.e1-2. 2010..The appropriate alanine aminotransferase (ALT) threshold value to use for diagnosis of chronic liver disease in children is unknown. We sought to develop gender-specific, biology-based, pediatric ALT thresholds...
- Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adultsYang Ho Kang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
Endocr J 55:1093-102. 2008..Among three markers, in overlap the multiple risk factors, ALT might have a strong association with metabolic syndrome in Korean adults...
- Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention studyNaveed Sattar
Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
Diabetes 53:2855-60. 2004..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
- Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologiesJ S Leeds
Departments of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
Diabet Med 26:1235-41. 2009To determine the prevalence of elevated alanine transaminase (ALT) in a large cohort of patients with Type 1 diabetes and to examine the clinical correlations and causes...
- Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apneaDaniel Norman
Department of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92103 8383, USA
Sleep 31:121-6. 2008....
- Efficacy and safety of prolonged 3-year telbivudine treatment in patients with chronic hepatitis BEdward J Gane
New Zealand Liver Unit, Auckland City Hospital, Auckland, New Zealand
Liver Int 31:676-84. 2011..Aims: To investigate the long-term efficacy and safety of telbivudine in the telbivudine-treated cohort from the GLOBE trial...
- Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesXin Yuan
Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
Am J Hum Genet 83:520-8. 2008..The specific associations with ALP levels may point to genes for bone or intestinal diseases...
- Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock modelFu Chao Liu
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Resuscitation 82:335-40. 2011..In this study, we hypothesized that ondansetron administration in male rats, after haemorrhagic shock, decreases cytokine production and protects against hepatic injury through a p38 mitogen-activated protein kinase (MAPK) pathway...
- Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measuresSeyed Moayed Alavian
Baqiyatallah Research Center for Gastroenterology and Liver Diseases BRCGL, Baqiyatallah University of Medical Sciences, Tehran Hepatitis Center, Tehran, Iran
Liver Int 29:159-63. 2009..To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) as well as the determination of associated metabolic abnormalities in Iranian school-aged children and adolescents...
- Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCVEmma C Thomson
Department of Virology, Wright Fleming Institute, Imperial College, London, UK
AIDS 23:89-93. 2009....
- Response to long-term lamivudine treatment (up to 5 years) in patients with severe chronic hepatitis B, role of genotype and drug resistanceD N Moskovitz
University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
J Viral Hepat 12:398-404. 2005..Cirrhosis was more prevalent with specific genotypes. We found no influence of HBV genotype on the development of resistance to lamivudine, however liver disease severity was influenced by genotype...
- Comparison between clevudine and entecavir treatment for antiviral-naïve patients with chronic hepatitis BHong Joo Kim
Department of Internal Medicine, Division of Gastroenterology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Liver Int 30:834-40. 2010..There has been no study comparing the clinical efficacy of clevudine and entecavir in antiviral-naïve patients with chronic hepatitis B (CHB)...
- Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes studyMonica Nannipieri
Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
Diabetes Care 28:1757-62. 2005..To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase [GGT], and alkaline phosphatase) may predict diabetes...
- Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver diseaseGeorge N Ioannou
Gastroenterology, Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington USA
Gastroenterology 128:627-35. 2005....
- Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
Pediatrics 115:e561-5. 2005..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown...
- Chronic hepatitis C in patients with persistently normal alanine transaminase levelsMitchell L Shiffman
Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA, and Hospital General de Valencia, Spain
Clin Gastroenterol Hepatol 4:645-52. 2006Many patients with chronic hepatitis C virus (HCV) have persistently normal serum alanine transaminase (ALT) levels...
- Cross-sectional and longitudinal association of serum alanine aminotransaminase and γ-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese peopleYu Xu
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
J Diabetes 3:38-47. 2011....
- The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in lifeStefano Romeo
Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
J Hepatol 53:335-8. 2010..In this study we add further insight into the role of PNPLA3 by exploring whether this association begins early in life in obese children or becomes manifest only in adulthood...
- Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis BH L Y Chan
Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
J Viral Hepat 16:36-44. 2009..In conclusion, transient elastography is a reasonable noninvasive tool to substitute liver biopsy among the lowest and highest risk patients for the assessment of liver fibrosis...
- Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virusPierre E Rollin
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:S364-71. 2007..This study has identified levels of analytes with prognostic value, which can also be used to target therapeutic interventions, and expands on the findings of prior blood tests conducted on this group of patients...
- Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over timeDar In Tai
Liver Research Unit, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taipei, Taiwan
Hepatology 49:1859-67. 2009....
- Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis CLaurent Castera
Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
J Hepatol 52:191-8. 2010..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
- A novel panel of blood markers to assess the degree of liver fibrosisPaul Cales
Laboratoire HIFIH, UPRES 3859, IFR 132, Universite, Angers, France
Hepatology 42:1373-81. 2005..Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis, blood tests for the area of liver fibrosis provide a quantitative estimation of the amount of fibrosis, which is especially useful in cirrhosis...
- Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis CCarolin Lackner
Department of Pathology, Medical University Graz, Graz, Austria
Hepatology 41:1376-82. 2005..In conclusion, simple fibrosis tests may render liver biopsy unnecessary only in a minority of patients with chronic HCV. Improved serum fibrosis markers with greater sensitivity for severe fibrosis or cirrhosis are needed...
- Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis BDongping Xu
Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
J Immunol 177:739-47. 2006..Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B...
- Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical backgroundSei ichiro Kojima
Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, 259 1193, Isehara, Bohseidai, Japan
J Gastroenterol 38:954-61. 2003..The aim of this investigation was to elucidate the time-course of changes in the prevalence of fatty liver, and to analyze its clinical backgrounds over the previous 12-year period...
- Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trialHans Orlent
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
J Hepatol 45:539-46. 2006..Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality of life...
- Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvementJohn B Dixon
Centre for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne, Australia
Obes Surg 16:1278-86. 2006..The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined...
- Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the ratVirginia Fernandez
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
Hepatology 45:170-7. 2007....
- Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding modelCheng Ji
USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
J Hepatol 45:717-24. 2006..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
- Mildly elevated liver transaminase levels in the asymptomatic patientPaul T Giboney
Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Am Fam Physician 71:1105-10. 2005Mild elevations in liver chemistry tests such as alanine transaminase and aspartate transaminase can reveal serious underlying conditions or have transient and benign etiologies...
- Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapyPatrick Ingiliz
Hepatology Department, AP HP, GH Pitié Salpétrière, Paris, France
Hepatology 49:436-42. 2009..Conclusions: HIV-infected patients on combined antiretroviral therapy with chronic transaminase elevation of unknown origin have a high rate of liver lesions, mostly consistent with NASH related to insulin resistance...
- Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trialChen Hua Liu
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Clin Infect Dis 47:1260-9. 2008..Whether a 48-week course of combination therapy shows a better SVR rate than a 24-week course of such therapy among Asian patients with HCV-1 infection has not been confirmed in multicenter, randomized studies...
- CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genesScott A Reisman
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
Toxicol Appl Pharmacol 236:109-14. 2009..Collectively, the present study shows that CDDO-Im pretreatment induces Nrf2-dependent cytoprotective genes and protects the liver from acetaminophen-induced hepatic injury...
- Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant systemDalibor Cerný
Institute of Pharmacology, Charles University in Prague, Czech Republic
Fitoterapia 82:786-91. 2011..4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model...
- Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and womenFabrice Bonnet
Service endocrinologie diabétologie, Centre Hospitalo Universitaire CHU Rennes, University Rennes 1, Inserm UMR 991, Rennes, France
Diabetes 60:1660-7. 2011..We explored the association of liver enzymes with peripheral and hepatic insulin resistance, insulin secretion, insulin clearance, and glucagon concentration...
- Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levelsStefan Zeuzem
Saarland University Hospital, Homburg Saar, Germany
Gastroenterology 127:1724-32. 2004....
- Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammationJia Xiao
Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region
J Ethnopharmacol 139:462-70. 2012..Lycium barbarum has been used as a traditional Chinese medicine to nourish liver, kidneys and the eyes...
- Analysis of alanine aminotransferase in various organs of soybean (Glycine max) and in dependence of different nitrogen fertilisers during hypoxic stressMarcio Rocha
Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
Amino Acids 39:1043-53. 2010..The work presented here indicates that AlaAT might not only be important during hypoxia, but also during the recovery phase after waterlogging, when oxygen is available to the tissue again...
- Ischemic preconditioning attenuates morphological and biochemical changes in hepatic ischemia/reperfusion in ratsLi Ming Jin
Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Pathobiology 77:136-46. 2010..We aimed to evaluate whether the reduction of apoptotic sinusoidal endothelial cells (SECs), induced by IPC, contributes to its protective effect...
- Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infectionChi Jen Chu
Department of Medicine, Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, USA
Hepatology 36:1408-15. 2002..Given the fluctuating course of HBeAg-negative chronic hepatitis, it is not possible to define a single cutoff HBV DNA value for differentiating inactive carriers from patients with HBeAg-negative chronic hepatitis...
- Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALTManoj Kumar
Department of Gastroenterology, G B Pant Hospital, New Delhi, India
Gastroenterology 134:1376-84. 2008..We studied the ALT, HBV DNA levels, and spectrum of histologic lesions in such patients...
- Clinical significance of alanine aminotransferase levels and the effect of ursodeoxycholic acid in hemodialysis patients with chronic hepatitis CChika Nishida
Department of Digestive and Life style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
J Gastroenterol 45:326-34. 2010..The natural history of hepatitis C virus (HCV) carriers and the effect of ursodeoxycholic acid (UDCA) have not been fully elucidated among hemodialysis (HD) patients...
- Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminasesFilippo Oliveri
UO Epatologia, Azienda Ospedaliero Universitaria Pisana, Via Paradisa n 2 Cisanello, Pisa 56124, Italy
World J Gastroenterol 14:6154-62. 2008..To investigate the usefulness of transient elastography by Fibroscan (FS), a rapid non-invasive technique to evaluate liver fibrosis, in the management of chronic hepatitis B virus (HBV) carriers...
- Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver diseaseAmy G Shah
Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Clin Gastroenterol Hepatol 7:1104-12. 2009..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
- Abundance of immunologically active alanine aminotransferase in sera of liver cirrhosis and hepatocellular carcinoma patientsHyun Jeong Kim
Department of Biomedical Sciences, Hallym University, Chuncheon, Korea
Clin Chem 55:1022-5. 2009..Although alanine aminotransferase (ALT) is a widely used indicator of liver function, ALT enzymatic activity may not always reflect the degree of liver damage. Improved methods or approaches would be useful...
- Risk of hepatocellular carcinoma in hepatitis B and prevention through treatmentMorris Sherman
University of Toronto, University Health Network, Toronto, ON, Canada
Cleve Clin J Med 76:S6-9. 2009..Viral suppression with continuous lamivudine therapy reduces the risk of complications and delays progression of liver disease as long as response is maintained...
- Noninvasive serum markers in the diagnosis of structural liver damage in chronic hepatitis C virus infectionEdison R Parise
Department of Gastroenterology, Federal University of Sao Paulo, Sao Paulo, Brazil
Liver Int 26:1095-9. 2006....
- Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States populationConstance E Ruhl
Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
Gastroenterology 136:477-85.e11. 2009..In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality...
- Is serum alanine transaminase level a reliable marker of histological disease in chronic hepatitis C infection?Faisal M Sanai
Department of Medicine, Division of Gastroenterology and Hepatology, Riyadh Military Hospital, Riyadh, Saudi Arabia
Liver Int 28:1011-8. 2008Approximately 20-30% of patients chronically infected with hepatitis C virus (HCV) have persistently normal alanine transaminase (PNALT) levels. These patients are described to have a mild degree of histological liver damage...
- Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in TaiwanChien Hua Chen
Digestive Disease Center, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan
J Gastroenterol Hepatol 22:1482-9. 2007..Through a population-based screening study, the prevalence and etiologies of elevated ALT in an adult population of Taiwan were assessed...
- Aspartate aminotransferase-to-platelet ratio index for fibrosis and cirrhosis prediction in chronic hepatitis C patientsRoberto Gomes da Silva Jr
Federal University of Sergipe, Federal University of Sergipe, Sao Cristovao, SE, Brazil
Braz J Infect Dis 12:15-9. 2008..APRI could identify significant fibrosis and cirrhosis at a high degree of accuracy in studied patients...
- Prevalence and etiology of abnormal liver tests in an adult population in Jilin, ChinaHong Zhang
Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China
Int J Med Sci 8:254-62. 2011..We determined the prevalence and etiologies of abnormal LTs in an adult population in Jilin, China...
- Novel role for amphiregulin in protection from liver injuryCarmen Berasain
Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada, Facultad de Medicina, Universidad de Navarra, Pio XII, 55, 31008 Pamplona, Spain
J Biol Chem 280:19012-20. 2005..These results show that amphiregulin is a protective factor induced in response to liver damage and that it may be therapeutic in liver diseases...
- Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen-negative chronic hepatitis B virus-infected patientsJoseph J Y Sung
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
J Viral Hepat 9:229-34. 2002..Patient demographics, viral mutants or genotypes failed to predict disease activity. Hence, serum ALT and HBV DNA levels offer the best prediction of natural course of HBeAg-negative chronic HBV infection...
- Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese womenSachin S Kunde
Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Hepatology 42:650-6. 2005..However, the diagnostic utility for ALT to identify NASH or IPF remains poor, and significant healthcare expenditures may be incurred if this standard is adopted...
- Hepatotoxicity development during antiretroviral therapy containing protease inhibitors in patients with HIV: the role of hepatitis B and C virus infectionAntonio Aceti
Department of Infectious and Tropical Diseases, II Faculty of Medicine, University of Rome La Sapienza, Rome, Italy
J Acquir Immune Defic Syndr 29:41-8. 2002..Moreover, chronic hepatotoxicity mainly occurs in patients who did not respond to therapy. Conversely, patients who did respond to ART seemed to show improvement of chronic liver infection...
- Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in miceM Yin
Laboratory of Hepatobiology, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Gastroenterology 117:942-52. 1999..To obtain clear evidence for or against the hypothesis that TNF-alpha is involved, we studied TNF receptor 1 (TNF-R1, p55) or 2 (TNF-R2, p75) knockout mice...
- Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosisJames Fung
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, Hong Kong
Liver Int 28:1408-16. 2008..A model using simple serum markers can predict liver stiffness, and further studies are required to validate the usefulness of these simple tests as non-invasive markers of fibrosis in CHB...
- Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis BStephanos J Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
N Engl J Med 348:800-7. 2003..Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials...
- Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortalityV Arndt
Department of Epidemiology, University of Ulm, Germany
Int Arch Occup Environ Health 71:405-12. 1998Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance...
- Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population studyRevital Kariv
Department of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Liver Int 26:445-50. 2006....
- The population distributions, upper normal limits and correlations between liver tests among Australian adolescentsJacob George
Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
J Paediatr Child Health 44:579-85. 2008..The purpose of this study was to describe the distributions of liver tests, to identify the upper normal limits (UNLs) and to describe the correlations among liver tests...
- Ethnicity and nonalcoholic fatty liver disease in an obesity clinic: the impact of triglyceridesEric R Kallwitz
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Dig Dis Sci 53:1358-63. 2008..In conclusion, in an obesity clinic population, elevated aminotransferase levels and hypertriglyceridemia were most common in Hispanics and least common in African Americans...
- Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causesRaika Jamali
Digestive Disease Research Center, Medical Sciences University of Tehran, Shariati Hospital, North Kargar Avenue, Tehran 14117, Iran
World J Gastroenterol 14:2867-71. 2008..To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran...
- Pretreatment alanine transaminase level may not be the most important predictor of HBeAg loss in the older patientJung Il Lee
Department of Internal Medicine, Division of Gastroenterology, Inha University College of Medicine, Incheon, Korea
Liver Int 29:231-6. 2009..However, initiating treatment in these patients might be argued against by the concept that the rate of HBeAg loss depends on the pretreatment ALT...
- Liver disease in adolescents: A cohort study of high-risk individualsDavid Van der Poorten
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia
Hepatology 46:1750-8. 2007..High rates of HCV infection and obesity-related liver disease exist in this group, and targeted interventions are needed to reduce future health-related morbidity...
- Prevalence of hepatitis B virus precore stop codon mutations in chronically infected childrenPhilip Wintermeyer
Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Germany
World J Gastroenterol 12:2235-8. 2006..To find out whether there is a significant difference in the prevalence of the precore stop codon mutation between HBeAg positive and anti-HBe positive children...
- Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic ratsA Eidi
Department of Biology, Science and Research Institute, Islamic Azad University, Tehran, Iran
Phytomedicine 13:624-9. 2006..The antidiabetic effect of garlic ethanolic extract (Allium sativum L.) was investigated in normal and streptozotocin-induced diabetic rats...
- Ratio of serum gamma-GT/ALT rather than ISDR variability is predictive for initial virological response to IFN-alpha in chronic HCV infectionS Mihm
Department of Internal Medicine, Georg August Universitat, Gottingen, Germany
J Med Virol 58:227-34. 1999..described previously for initial virological response, namely the ratio of serum gamma-glutamyltransferase/alanine transaminase (gamma-GT/ALT) activity in connection with virus genotypes 1a, 1b, and 3a, prospectively and to compare the ..
- Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United StatesM M Jamal
Division of Gastroenterology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5271, USA
Hepatology 30:1307-11. 1999Approximately one third of patients with chronic hepatitis C virus (HCV) infection have normal alanine transaminase (ALT) levels...
- Serum aminotransferase activity and mortality risk in a United States communityTae Hoon Lee
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
Hepatology 47:880-7. 2008..78 for >2x ULN). SMR was also higher for abnormal ALT (SMR = 1.21 for 1-2x ULN and 1.51 for >2x ULN). In contrast, normal AST or ALT was associated with a risk of death lower than expected (SMR 0.95 for AST, 0.61 for ALT)...
- Alanine aminotransferase decreases with age: the Rancho Bernardo StudyMamie H Dong
Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 5:e14254. 2010..This study examines the association between serum ALT and age in a community-dwelling cohort in the United States...
- Programmed death-1 expression is associated with the disease status in hepatitis B virus infectionPian Ye
Department of Hepatology and Infectious Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
World J Gastroenterol 14:4551-7. 2008....
- APRI: an easy and validated predictor of hepatic fibrosis in chronic hepatitis CNed Snyder
Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA
J Clin Gastroenterol 40:535-42. 2006..To evaluate the aspartate aminotransferase/platelet ratio index (APRI) as a predictor of the presence or absence of significant fibrosis on liver biopsy of patients with chronic hepatitis C (HCV)...
- Serum activity of alanine aminotransferase (ALT) as an indicator of health and diseaseW Ray Kim
Mayo Clinic College of Medicine, Rochester, MN, USA
Hepatology 47:1363-70. 2008
Research Grants165 found, 100 shown here
- Anti-Inflammatory effect of Cholinergic Pathway:IschemiaElahe Crockett; Fiscal Year: 2005..The liver injury will be evaluated by liver histopathology and changes of the plasma alanine transaminase (ALT) levels. II...
- Novel ALT Isoenzymes and Their Diagnositc ApplicationDa Wei Gong; Fiscal Year: 2003For nearly fifty years, alanine transaminase (ALT) has been a widely used clinical diagnostic marker of acute and chronic hepatic injury...
- Hepatoxicity Clincal Research NetworkPaul Watkins; Fiscal Year: 2007..We anticipate that our proposed infrastructure will allow successful identification and enrollment of patients experiencing severe DILl within the mid-Atlantic region of the country. ..
- FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4Paul Watkins; Fiscal Year: 2007..abstract_text> ..
- HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVERAdrian Di Bisceglie; Fiscal Year: 2003..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
- HIF-1alpha and VEGF in Acetaminophen Toxicity and RepairLaura James; Fiscal Year: 2007..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
- Liver innate immunity in drug-induced liver diseaseZhang Xu Liu; Fiscal Year: 2006..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..
- Alcohol Dependence in General Medical SettingsScott Stewart; Fiscal Year: 2006....
- Breast Cancer Prevention and Treatment with Noni juiceMian Ying Wang; Fiscal Year: 2007..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
- Green Tea Polyphenols: A Novel Approach to IBDHELIEH OZ; Fiscal Year: 2004..abstract_text> ..
- Michigan Hepatotoxicity Clinical Research NetworkRobert Fontana; Fiscal Year: 2007..abstract_text> ..
- Evaluation of a Biomarker for Acetaminophen ToxicityLaura James; Fiscal Year: 2005..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
- NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITYLaura James; Fiscal Year: 2004..abstract_text> ..
- Role of aberrant regulation of organelle stress responses in alcohol-induced liveCheng Ji; Fiscal Year: 2009..This research is to understand how alcohol promotes injury processes in the two organelles and how organelle damages contribute to liver disease which will open new avenues for preventing and treating liver disease. ..
- Liver innate immunity in drug-induced liver disease.Zhang Xu Liu; Fiscal Year: 2010..It is thus of great interest and importance to understand the mechanism of action leading to liver toxicity so that better therapeutics can be developed to prevent or ameliorate drug-induced liver injury. ..
- HIF-1alpha and VEGF in Acetaminophen Toxicity and RepairLaura P James; Fiscal Year: 2010..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
- Treatment of PTSD in Cardiac PatientsEyal Shemesh; Fiscal Year: 2007..We will evaluate the safety as well as the potential benefits of this approach. A full efficacy trial is expected to follow this pilot study if the results are encouraging. ..
- Identification of new mechanistic biomarkers of adverse responses to acetaminopheLaura P James; Fiscal Year: 2010..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
- Identification of new mechanistic biomarkers of adverse responses to acetaminopheLaura James; Fiscal Year: 2009..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
- Medication Adherence in Children Who Had a Liver Transplant (MALT)Eyal Shemesh; Fiscal Year: 2009..The results will help transplant centers identify these children and improve overall post transplant survival, and will also inform other areas of medicine in which children may not take their medications as prescribed. ..
- Phosphatidylethanol as an Alcohol Biomarker in Patients with Liver DiseaseScott Stewart; Fiscal Year: 2009..Results may provide health care providers with an important tool for detecting heavy drinking, for monitoring response to alcohol treatment, and for early detection of relapse. ..
- Phosphatidylethanol as an Alcohol Biomarker in Patients with Liver DiseaseScott H Stewart; Fiscal Year: 2010..Results may provide health care providers with an important tool for detecting heavy drinking, for monitoring response to alcohol treatment, and for early detection of relapse. ..
- Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.Cheng Ji; Fiscal Year: 2010..Understanding of additive/synergistic effects of HIV PIs and alcohol on the ER stress that worsens liver injury will provide better strategies to improve care for HIV-infected patients. ..
- Relationship of metabolic abnormalities to hepatic steatosis in HIVRichard Sterling; Fiscal Year: 2007..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. ..
- HCV-HIV Coinfection: Impact of Immune DysfunctionRichard Sterling; Fiscal Year: 2007..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..
- Adipose and Fatty Liver in the Metabolic SyndromeJeffrey Schwimmer; Fiscal Year: 2006..abstract_text> ..
- A Multi-Center Study of Acute Liver Failure in AdultsWilliam Lee; Fiscal Year: 2007....
- A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILUREWilliam Lee; Fiscal Year: 2003....
- A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILUREWilliam Lee; Fiscal Year: 2004..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
- PTSD and nonadherence in pediatric transplant patientsEyal Shemesh; Fiscal Year: 2005..This proposal will therefore allow the principal investigator to develop into an independent investigator performing clinical research into the phenomenology and treatment of co-morbid psychiatric and medical illness in children. ..
- Non-parenteral transmission of hepatitis CChia Wang; Fiscal Year: 2007....
- Pulmonary Hypertension and the Hypoxic Response in SCDVictor Gordeuk; Fiscal Year: 2007..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
- MECHANISM OF GLUTATHIONE CONJUGATE DEPENDENT TOXICITYArthur Cooper; Fiscal Year: 2007..The findings should elucidate the link between exposure to certain halogenated xenobiotics and impaired energy metabolism, and may suggest a means to minimize the toxic effects in heavily exposed individuals. ..
- Alcohol Stimulation and Sedation in Binge DrinkersAndrea C King; Fiscal Year: 2010..Equally important, the potential protective factors underlying low risk drinking will also be examined. ..
- HIV Disease, Drug Abuse, & Nutrient Therapy in BotswanaMarianna Baum; Fiscal Year: 2007..Since antiretroviral therapies are not readily available to HIV infected adults in most countries in Africa, this study may provide an alternative approach to retard HIV progression. ..
- Howard-CNMC Sickle Cell Disease Clinical CenterVictor Gordeuk; Fiscal Year: 2007..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
- Regeneration of the Lower Urinary Tract in Nonhuman PrimatesJames Koudy Williams; Fiscal Year: 2010....
- Longitudinal Comparative Effectiveness & Safety of Biologics in AutoimmunityJeffrey R Curtis; Fiscal Year: 2010....
- Acupuncture to aid post-colectomy recovery in colorectal cancer patientsGary Deng; Fiscal Year: 2007....
- VIRAHEP-C Clinical CenterAnna Lok; Fiscal Year: 2005..abstract_text> ..
- NALTREXONE IN DRINKERS SMOKING RESPONSEAndrea King; Fiscal Year: 2002..Examining a targeted treatment combining pharmacotherapy and behavioral treatment for this subgroup is of great importance, as alcohol abusers show increased mortality more due to tobacco than alcohol-related illness. ..
- Proteomics and Biomarkers for Hepatocellular CancerNezam Afdhal; Fiscal Year: 2004..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
- CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSISSally Huber; Fiscal Year: 2002..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
- PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESISNezam Afdhal; Fiscal Year: 2002..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
- GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETINGPaul Watkins; Fiscal Year: 2006..abstract_text> ..
- ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORElan Louis; Fiscal Year: 2003..In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History. ..