alanine transaminase

Summary

Summary: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.

Top Publications

  1. ncbi Updated definitions of healthy ranges for serum alanine aminotransferase levels
    Daniele Prati
    Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
    Ann Intern Med 137:1-10. 2002
  2. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
  3. ncbi The current state of serum biomarkers of hepatotoxicity
    Josef Ozer
    Safety Assessment, Merck Research Laboratories, West Point, PA, USA
    Toxicology 245:194-205. 2008
  4. ncbi Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease
    Roger K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Diabetes Metab Res Rev 22:437-43. 2006
  5. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
  6. ncbi Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
  7. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
  8. doi How can we enhance the performance of liver stiffness measurement using FibroScan in diagnosing liver cirrhosis in patients with chronic hepatitis B?
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 44:66-71. 2010
  9. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
  10. ncbi Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
    Constance E Ruhl
    Social and Scientific Systems, Inc, 8757 Georgia Avenue, 12th Floor, Silver Spring, MD 20910, USA
    Gastroenterology 124:71-9. 2003

Detail Information

Publications299 found, 100 shown here

  1. ncbi Updated definitions of healthy ranges for serum alanine aminotransferase levels
    Daniele Prati
    Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
    Ann Intern Med 137:1-10. 2002
    ..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
  2. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
    ....
  3. ncbi The current state of serum biomarkers of hepatotoxicity
    Josef Ozer
    Safety Assessment, Merck Research Laboratories, West Point, PA, USA
    Toxicology 245:194-205. 2008
    ..Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in early clinical trials...
  4. ncbi Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease
    Roger K Schindhelm
    Department of Endocrinology Diabetes Centre, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Diabetes Metab Res Rev 22:437-43. 2006
    ..In addition, treatment strategies to ameliorate NAFLD and the associated risks are discussed...
  5. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
    ..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
  6. ncbi Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
    ..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
  7. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
    ..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
  8. doi How can we enhance the performance of liver stiffness measurement using FibroScan in diagnosing liver cirrhosis in patients with chronic hepatitis B?
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 44:66-71. 2010
    ....
  9. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  10. ncbi Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
    Constance E Ruhl
    Social and Scientific Systems, Inc, 8757 Georgia Avenue, 12th Floor, Silver Spring, MD 20910, USA
    Gastroenterology 124:71-9. 2003
    ..We examined whether central adiposity and metabolic markers explain the association of body mass index (BMI as kg/m(2)) with abnormal serum alanine aminotransferase (ALT) activity in a national, population-based study...
  11. ncbi High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  12. ncbi Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study
    Roger K Schindhelm
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 191:391-6. 2007
    ..Further studies should confirm these findings and elucidate the pathophysiological mechanisms...
  13. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  14. pmc A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy
    M F Yuen
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gut 52:416-9. 2003
    ..In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients...
  15. doi Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C
    Maribel Rodriguez-Torres
    Fundacion de Investigacion de Diego, San Juan, Puerto Rico
    N Engl J Med 360:257-67. 2009
    ..We evaluated the effect of Latino ethnic background on the response to treatment with peginterferon alfa-2a and ribavirin in patients infected with HCV genotype 1 who had not been treated previously...
  16. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
    ....
  17. ncbi Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histology
    Jae Keun Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Hepatology 51:1577-83. 2010
    ..The mean ALT concentrations for subjects within the Prati criteria were significantly lower than for those outside the criteria (16.7 versus 19.5 IU/L for men, 12.8 versus 14.9 IU/L for women; P < 0.001)...
  18. ncbi Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury
    Ayano Itoh
    Graduate School of Pharmaceutical Sciences, Osaka University
    Biol Pharm Bull 32:1215-9. 2009
    ..Together, these findings indicate that the phenolic compounds in L.E.M. are hepatoprotective through their suppression of immune-mediated liver inflammation...
  19. ncbi Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases
    B Coco
    UO Gastroenterologia ed Epatologia Ospedaliera, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    J Viral Hepat 14:360-9. 2007
    ....
  20. pmc Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
    Daniel J Antoine
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    J Hepatol 56:1070-9. 2012
    ..The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity...
  21. ncbi Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: virological breakthrough is also dependent on adherence to medication
    Hidehiro Kamezaki
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Scand J Gastroenterol 46:1111-7. 2011
    ....
  22. ncbi Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    S Romeo
    Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
    Int J Obes (Lond) 34:190-4. 2010
    ..Intriguingly, initial findings in cohorts with a mean body mass index (BMI) of 30 kg m(-2) also suggested that it is associated with elevated liver enzymes but not with insulin resistance and dyslipidaemia...
  23. ncbi Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease
    Yoosoo Chang
    Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Clin Chem 53:686-92. 2007
    ..We performed a prospective study to examine the association between ALT within its reference interval and risk for subsequent development of NAFLD...
  24. pmc Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice
    Run Zhi Zhu
    Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
    World J Gastroenterol 16:2771-9. 2010
    ..To evaluate the effects of positive regulation of recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury in mice induced by carbon tetrachloride (CCl(4))...
  25. ncbi A novel liver stiffness measurement-based prediction model for cirrhosis in hepatitis B patients
    Beom Kyung Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Liver Int 30:1073-81. 2010
    ..We developed a new LSM-based prediction model for cirrhosis and estimated the thresholds for different ALT levels...
  26. pmc SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103 8450, USA
    Gastroenterology 138:1357-64, 1364.e1-2. 2010
    ..The appropriate alanine aminotransferase (ALT) threshold value to use for diagnosis of chronic liver disease in children is unknown. We sought to develop gender-specific, biology-based, pediatric ALT thresholds...
  27. ncbi Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults
    Yang Ho Kang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
    Endocr J 55:1093-102. 2008
    ..Among three markers, in overlap the multiple risk factors, ALT might have a strong association with metabolic syndrome in Korean adults...
  28. ncbi Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Diabetes 53:2855-60. 2004
    ..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
  29. doi Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies
    J S Leeds
    Departments of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
    Diabet Med 26:1235-41. 2009
    To determine the prevalence of elevated alanine transaminase (ALT) in a large cohort of patients with Type 1 diabetes and to examine the clinical correlations and causes...
  30. pmc Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea
    Daniel Norman
    Department of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92103 8383, USA
    Sleep 31:121-6. 2008
    ....
  31. ncbi Efficacy and safety of prolonged 3-year telbivudine treatment in patients with chronic hepatitis B
    Edward J Gane
    New Zealand Liver Unit, Auckland City Hospital, Auckland, New Zealand
    Liver Int 31:676-84. 2011
    ..In the GLOBE trial, telbivudine demonstrated superior efficacy to lamivudine at 2 years in patients with chronic hepatitis B (CHB)...
  32. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..The specific associations with ALP levels may point to genes for bone or intestinal diseases...
  33. doi Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model
    Fu Chao Liu
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Resuscitation 82:335-40. 2011
    ..In this study, we hypothesized that ondansetron administration in male rats, after haemorrhagic shock, decreases cytokine production and protects against hepatic injury through a p38 mitogen-activated protein kinase (MAPK) pathway...
  34. doi Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures
    Seyed Moayed Alavian
    Baqiyatallah Research Center for Gastroenterology and Liver Diseases BRCGL, Baqiyatallah University of Medical Sciences, Tehran Hepatitis Center, Tehran, Iran
    Liver Int 29:159-63. 2009
    ..To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) as well as the determination of associated metabolic abnormalities in Iranian school-aged children and adolescents...
  35. pmc Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV
    Emma C Thomson
    Department of Virology, Wright Fleming Institute, Imperial College, London, UK
    AIDS 23:89-93. 2009
    ....
  36. ncbi Response to long-term lamivudine treatment (up to 5 years) in patients with severe chronic hepatitis B, role of genotype and drug resistance
    D N Moskovitz
    University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Viral Hepat 12:398-404. 2005
    ..Cirrhosis was more prevalent with specific genotypes. We found no influence of HBV genotype on the development of resistance to lamivudine, however liver disease severity was influenced by genotype...
  37. doi Comparison between clevudine and entecavir treatment for antiviral-naïve patients with chronic hepatitis B
    Hong Joo Kim
    Department of Internal Medicine, Division of Gastroenterology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Liver Int 30:834-40. 2010
    ..There has been no study comparing the clinical efficacy of clevudine and entecavir in antiviral-naïve patients with chronic hepatitis B (CHB)...
  38. ncbi Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
    ..To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase [GGT], and alkaline phosphatase) may predict diabetes...
  39. ncbi Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease
    George N Ioannou
    Gastroenterology, Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington USA
    Gastroenterology 128:627-35. 2005
    ....
  40. ncbi Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 115:e561-5. 2005
    ..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown...
  41. ncbi Chronic hepatitis C in patients with persistently normal alanine transaminase levels
    Mitchell L Shiffman
    Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA, and Hospital General de Valencia, Spain
    Clin Gastroenterol Hepatol 4:645-52. 2006
    Many patients with chronic hepatitis C virus (HCV) have persistently normal serum alanine transaminase (ALT) levels...
  42. doi Cross-sectional and longitudinal association of serum alanine aminotransaminase and γ-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese people
    Yu Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 3:38-47. 2011
    ....
  43. doi The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
    Stefano Romeo
    Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
    J Hepatol 53:335-8. 2010
    ..In this study we add further insight into the role of PNPLA3 by exploring whether this association begins early in life in obese children or becomes manifest only in adulthood...
  44. doi Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B
    H L Y Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Viral Hepat 16:36-44. 2009
    ..In conclusion, transient elastography is a reasonable noninvasive tool to substitute liver biopsy among the lowest and highest risk patients for the assessment of liver fibrosis...
  45. ncbi Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus
    Pierre E Rollin
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S364-71. 2007
    ..This study has identified levels of analytes with prognostic value, which can also be used to target therapeutic interventions, and expands on the findings of prior blood tests conducted on this group of patients...
  46. doi Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time
    Dar In Tai
    Liver Research Unit, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taipei, Taiwan
    Hepatology 49:1859-67. 2009
    ....
  47. doi Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire C H U de Bordeaux, Pessac, France
    J Hepatol 52:191-8. 2010
    ..The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients...
  48. ncbi A novel panel of blood markers to assess the degree of liver fibrosis
    Paul Cales
    Laboratoire HIFIH, UPRES 3859, IFR 132, Universite, Angers, France
    Hepatology 42:1373-81. 2005
    ..Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis, blood tests for the area of liver fibrosis provide a quantitative estimation of the amount of fibrosis, which is especially useful in cirrhosis...
  49. ncbi Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C
    Carolin Lackner
    Department of Pathology, Medical University Graz, Graz, Austria
    Hepatology 41:1376-82. 2005
    ..In conclusion, simple fibrosis tests may render liver biopsy unnecessary only in a minority of patients with chronic HCV. Improved serum fibrosis markers with greater sensitivity for severe fibrosis or cirrhosis are needed...
  50. ncbi Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    Dongping Xu
    Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
    J Immunol 177:739-47. 2006
    ..Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B...
  51. ncbi Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background
    Sei ichiro Kojima
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, 259 1193, Isehara, Bohseidai, Japan
    J Gastroenterol 38:954-61. 2003
    ..The aim of this investigation was to elucidate the time-course of changes in the prevalence of fatty liver, and to analyze its clinical backgrounds over the previous 12-year period...
  52. ncbi Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trial
    Hans Orlent
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    J Hepatol 45:539-46. 2006
    ..Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality of life...
  53. ncbi Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement
    John B Dixon
    Centre for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne, Australia
    Obes Surg 16:1278-86. 2006
    ..The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined...
  54. ncbi Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Hepatology 45:170-7. 2007
    ....
  55. ncbi Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Hepatol 45:717-24. 2006
    ..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
  56. ncbi Mildly elevated liver transaminase levels in the asymptomatic patient
    Paul T Giboney
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am Fam Physician 71:1105-10. 2005
    Mild elevations in liver chemistry tests such as alanine transaminase and aspartate transaminase can reveal serious underlying conditions or have transient and benign etiologies...
  57. ncbi Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy
    Patrick Ingiliz
    Hepatology Department, AP HP, GH Pitié Salpétrière, Paris, France
    Hepatology 49:436-42. 2009
    ..The presence of NASH was correlated with high fasting glycemia and insulin levels, not with liver mitochondrial function or mitochondrial DNA content...
  58. doi Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial
    Chen Hua Liu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 47:1260-9. 2008
    ..Whether a 48-week course of combination therapy shows a better SVR rate than a 24-week course of such therapy among Asian patients with HCV-1 infection has not been confirmed in multicenter, randomized studies...
  59. pmc CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 236:109-14. 2009
    ..Collectively, the present study shows that CDDO-Im pretreatment induces Nrf2-dependent cytoprotective genes and protects the liver from acetaminophen-induced hepatic injury...
  60. doi Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system
    Dalibor Cerný
    Institute of Pharmacology, Charles University in Prague, Czech Republic
    Fitoterapia 82:786-91. 2011
    ..4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model...
  61. pmc Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women
    Fabrice Bonnet
    Service endocrinologie diabétologie, Centre Hospitalo Universitaire CHU Rennes, University Rennes 1, Inserm UMR 991, Rennes, France
    Diabetes 60:1660-7. 2011
    ..We explored the association of liver enzymes with peripheral and hepatic insulin resistance, insulin secretion, insulin clearance, and glucagon concentration...
  62. ncbi Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels
    Stefan Zeuzem
    Saarland University Hospital, Homburg Saar, Germany
    Gastroenterology 127:1724-32. 2004
    ....
  63. doi Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation
    Jia Xiao
    Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region
    J Ethnopharmacol 139:462-70. 2012
    ..Lycium barbarum has been used as a traditional Chinese medicine to nourish liver, kidneys and the eyes...
  64. pmc Analysis of alanine aminotransferase in various organs of soybean (Glycine max) and in dependence of different nitrogen fertilisers during hypoxic stress
    Marcio Rocha
    Max Planck Institute of Molecular Plant Physiology, Potsdam Golm, Germany
    Amino Acids 39:1043-53. 2010
    ..The work presented here indicates that AlaAT might not only be important during hypoxia, but also during the recovery phase after waterlogging, when oxygen is available to the tissue again...
  65. ncbi Ischemic preconditioning attenuates morphological and biochemical changes in hepatic ischemia/reperfusion in rats
    Li Ming Jin
    Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Pathobiology 77:136-46. 2010
    ..We aimed to evaluate whether the reduction of apoptotic sinusoidal endothelial cells (SECs), induced by IPC, contributes to its protective effect...
  66. ncbi Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection
    Chi Jen Chu
    Department of Medicine, Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Hepatology 36:1408-15. 2002
    ..Given the fluctuating course of HBeAg-negative chronic hepatitis, it is not possible to define a single cutoff HBV DNA value for differentiating inactive carriers from patients with HBeAg-negative chronic hepatitis...
  67. doi Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Gastroenterology 134:1376-84. 2008
    ..We studied the ALT, HBV DNA levels, and spectrum of histologic lesions in such patients...
  68. doi Clinical significance of alanine aminotransferase levels and the effect of ursodeoxycholic acid in hemodialysis patients with chronic hepatitis C
    Chika Nishida
    Department of Digestive and Life style Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    J Gastroenterol 45:326-34. 2010
    ..The natural history of hepatitis C virus (HCV) carriers and the effect of ursodeoxycholic acid (UDCA) have not been fully elucidated among hemodialysis (HD) patients...
  69. pmc Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases
    Filippo Oliveri
    UO Epatologia, Azienda Ospedaliero Universitaria Pisana, Via Paradisa n 2 Cisanello, Pisa 56124, Italy
    World J Gastroenterol 14:6154-62. 2008
    ..To investigate the usefulness of transient elastography by Fibroscan (FS), a rapid non-invasive technique to evaluate liver fibrosis, in the management of chronic hepatitis B virus (HBV) carriers...
  70. pmc Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  71. doi Abundance of immunologically active alanine aminotransferase in sera of liver cirrhosis and hepatocellular carcinoma patients
    Hyun Jeong Kim
    Department of Biomedical Sciences, Hallym University, Chuncheon, Korea
    Clin Chem 55:1022-5. 2009
    ..Although alanine aminotransferase (ALT) is a widely used indicator of liver function, ALT enzymatic activity may not always reflect the degree of liver damage. Improved methods or approaches would be useful...
  72. doi Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment
    Morris Sherman
    University of Toronto, University Health Network, Toronto, ON, Canada
    Cleve Clin J Med 76:S6-9. 2009
    ..Viral suppression with continuous lamivudine therapy reduces the risk of complications and delays progression of liver disease as long as response is maintained...
  73. ncbi Noninvasive serum markers in the diagnosis of structural liver damage in chronic hepatitis C virus infection
    Edison R Parise
    Department of Gastroenterology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Liver Int 26:1095-9. 2006
    ....
  74. doi Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population
    Constance E Ruhl
    Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
    Gastroenterology 136:477-85.e11. 2009
    ..In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality...
  75. ncbi Is serum alanine transaminase level a reliable marker of histological disease in chronic hepatitis C infection?
    Faisal M Sanai
    Department of Medicine, Division of Gastroenterology and Hepatology, Riyadh Military Hospital, Riyadh, Saudi Arabia
    Liver Int 28:1011-8. 2008
    Approximately 20-30% of patients chronically infected with hepatitis C virus (HCV) have persistently normal alanine transaminase (PNALT) levels. These patients are described to have a mild degree of histological liver damage...
  76. ncbi Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan
    Chien Hua Chen
    Digestive Disease Center, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan
    J Gastroenterol Hepatol 22:1482-9. 2007
    ..Through a population-based screening study, the prevalence and etiologies of elevated ALT in an adult population of Taiwan were assessed...
  77. ncbi Aspartate aminotransferase-to-platelet ratio index for fibrosis and cirrhosis prediction in chronic hepatitis C patients
    Roberto Gomes da Silva Jr
    Federal University of Sergipe, Federal University of Sergipe, Sao Cristovao, SE, Brazil
    Braz J Infect Dis 12:15-9. 2008
    ..APRI could identify significant fibrosis and cirrhosis at a high degree of accuracy in studied patients...
  78. pmc Prevalence and etiology of abnormal liver tests in an adult population in Jilin, China
    Hong Zhang
    Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China
    Int J Med Sci 8:254-62. 2011
    ..We determined the prevalence and etiologies of abnormal LTs in an adult population in Jilin, China...
  79. ncbi Novel role for amphiregulin in protection from liver injury
    Carmen Berasain
    Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada, Facultad de Medicina, Universidad de Navarra, Pio XII, 55, 31008 Pamplona, Spain
    J Biol Chem 280:19012-20. 2005
    ..These results show that amphiregulin is a protective factor induced in response to liver damage and that it may be therapeutic in liver diseases...
  80. ncbi Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen-negative chronic hepatitis B virus-infected patients
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Viral Hepat 9:229-34. 2002
    ..Patient demographics, viral mutants or genotypes failed to predict disease activity. Hence, serum ALT and HBV DNA levels offer the best prediction of natural course of HBeAg-negative chronic HBV infection...
  81. ncbi Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women
    Sachin S Kunde
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Hepatology 42:650-6. 2005
    ..However, the diagnostic utility for ALT to identify NASH or IPF remains poor, and significant healthcare expenditures may be incurred if this standard is adopted...
  82. ncbi Hepatotoxicity development during antiretroviral therapy containing protease inhibitors in patients with HIV: the role of hepatitis B and C virus infection
    Antonio Aceti
    Department of Infectious and Tropical Diseases, II Faculty of Medicine, University of Rome La Sapienza, Rome, Italy
    J Acquir Immune Defic Syndr 29:41-8. 2002
    ..Moreover, chronic hepatotoxicity mainly occurs in patients who did not respond to therapy. Conversely, patients who did respond to ART seemed to show improvement of chronic liver infection...
  83. ncbi Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    M Yin
    Laboratory of Hepatobiology, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Gastroenterology 117:942-52. 1999
    ..To obtain clear evidence for or against the hypothesis that TNF-alpha is involved, we studied TNF receptor 1 (TNF-R1, p55) or 2 (TNF-R2, p75) knockout mice...
  84. ncbi Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, Hong Kong
    Liver Int 28:1408-16. 2008
    ..Abstract Aim: To correlate liver stiffness with demographical factors and routine liver biochemistry and to assess the predictive value of these as potential markers of fibrosis...
  85. ncbi Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    N Engl J Med 348:800-7. 2003
    ..Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials...
  86. ncbi Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality
    V Arndt
    Department of Epidemiology, University of Ulm, Germany
    Int Arch Occup Environ Health 71:405-12. 1998
    Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance...
  87. ncbi Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study
    Revital Kariv
    Department of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Liver Int 26:445-50. 2006
    ....
  88. doi The population distributions, upper normal limits and correlations between liver tests among Australian adolescents
    Jacob George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    J Paediatr Child Health 44:579-85. 2008
    ..The purpose of this study was to describe the distributions of liver tests, to identify the upper normal limits (UNLs) and to describe the correlations among liver tests...
  89. doi Ethnicity and nonalcoholic fatty liver disease in an obesity clinic: the impact of triglycerides
    Eric R Kallwitz
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Dig Dis Sci 53:1358-63. 2008
    ..In conclusion, in an obesity clinic population, elevated aminotransferase levels and hypertriglyceridemia were most common in Hispanics and least common in African Americans...
  90. pmc Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes
    Raika Jamali
    Digestive Disease Research Center, Medical Sciences University of Tehran, Shariati Hospital, North Kargar Avenue, Tehran 14117, Iran
    World J Gastroenterol 14:2867-71. 2008
    ..To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran...
  91. ncbi Pretreatment alanine transaminase level may not be the most important predictor of HBeAg loss in the older patient
    Jung Il Lee
    Department of Internal Medicine, Division of Gastroenterology, Inha University College of Medicine, Incheon, Korea
    Liver Int 29:231-6. 2009
    ..However, initiating treatment in these patients might be argued against by the concept that the rate of HBeAg loss depends on the pretreatment ALT...
  92. ncbi Liver disease in adolescents: A cohort study of high-risk individuals
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia
    Hepatology 46:1750-8. 2007
    ..High rates of HCV infection and obesity-related liver disease exist in this group, and targeted interventions are needed to reduce future health-related morbidity...
  93. pmc Prevalence of hepatitis B virus precore stop codon mutations in chronically infected children
    Philip Wintermeyer
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Germany
    World J Gastroenterol 12:2235-8. 2006
    ..To find out whether there is a significant difference in the prevalence of the precore stop codon mutation between HBeAg positive and anti-HBe positive children...
  94. ncbi Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats
    A Eidi
    Department of Biology, Science and Research Institute, Islamic Azad University, Tehran, Iran
    Phytomedicine 13:624-9. 2006
    ..The antidiabetic effect of garlic ethanolic extract (Allium sativum L.) was investigated in normal and streptozotocin-induced diabetic rats...
  95. ncbi Ratio of serum gamma-GT/ALT rather than ISDR variability is predictive for initial virological response to IFN-alpha in chronic HCV infection
    S Mihm
    Department of Internal Medicine, Georg August Universitat, Gottingen, Germany
    J Med Virol 58:227-34. 1999
    ..described previously for initial virological response, namely the ratio of serum gamma-glutamyltransferase/alanine transaminase (gamma-GT/ALT) activity in connection with virus genotypes 1a, 1b, and 3a, prospectively and to compare the ..
  96. ncbi Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States
    M M Jamal
    Division of Gastroenterology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5271, USA
    Hepatology 30:1307-11. 1999
    Approximately one third of patients with chronic hepatitis C virus (HCV) infection have normal alanine transaminase (ALT) levels...
  97. ncbi Serum aminotransferase activity and mortality risk in a United States community
    Tae Hoon Lee
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 47:880-7. 2008
    ..78 for >2x ULN). SMR was also higher for abnormal ALT (SMR = 1.21 for 1-2x ULN and 1.51 for >2x ULN). In contrast, normal AST or ALT was associated with a risk of death lower than expected (SMR 0.95 for AST, 0.61 for ALT)...
  98. pmc Alanine aminotransferase decreases with age: the Rancho Bernardo Study
    Mamie H Dong
    Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14254. 2010
    ..This study examines the association between serum ALT and age in a community-dwelling cohort in the United States...
  99. pmc Programmed death-1 expression is associated with the disease status in hepatitis B virus infection
    Pian Ye
    Department of Hepatology and Infectious Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
    World J Gastroenterol 14:4551-7. 2008
    ....
  100. ncbi APRI: an easy and validated predictor of hepatic fibrosis in chronic hepatitis C
    Ned Snyder
    Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA
    J Clin Gastroenterol 40:535-42. 2006
    ..To evaluate the aspartate aminotransferase/platelet ratio index (APRI) as a predictor of the presence or absence of significant fibrosis on liver biopsy of patients with chronic hepatitis C (HCV)...
  101. doi Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
    W Ray Kim
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 47:1363-70. 2008

Research Grants165 found, 100 shown here

  1. ART PHARMACOKINETICS IN SEVERELY MALNOURISHED HIV-INFECTED CHILDREN
    Ericka Hayes; Fiscal Year: 2009
    ..peroxidase, and oxidized serum proteins), hepatic function and integrity (quantified by albumin, alanine transaminase and aspartate transaminase), renal function (measured by serum cystatin C) and immunologic function (..
  2. Anti-Inflammatory effect of Cholinergic Pathway:Ischemia
    Elahe Crockett; Fiscal Year: 2004
    ..The liver injury will be evaluated by liver histopathology and changes of the plasma alanine transaminase (ALT) levels. II...
  3. Anti-Inflammatory effect of Cholinergic Pathway:Ischemia
    Elahe Crockett; Fiscal Year: 2005
    ..The liver injury will be evaluated by liver histopathology and changes of the plasma alanine transaminase (ALT) levels. II...
  4. Novel ALT Isoenzymes and Their Diagnositc Application
    Da Wei Gong; Fiscal Year: 2002
    For nearly fifty years, alanine transaminase (ALT) has been a widely used clinical diagnostic marker of acute and chronic hepatic injury...
  5. Novel ALT Isoenzymes and Their Diagnositc Application
    Da Wei Gong; Fiscal Year: 2003
    For nearly fifty years, alanine transaminase (ALT) has been a widely used clinical diagnostic marker of acute and chronic hepatic injury...
  6. Hepatoxicity Clincal Research Network
    Paul Watkins; Fiscal Year: 2007
    ..We anticipate that our proposed infrastructure will allow successful identification and enrollment of patients experiencing severe DILl within the mid-Atlantic region of the country. ..
  7. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2002
    ..abstract_text> ..
  8. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2004
    ..abstract_text> ..
  9. UNC Clinical Translation Science Award-K12 Scholars Program (KL2)
    Paul Watkins; Fiscal Year: 2008
    ..critical if we are to make scientific discovery a tangible part of medical care. ..
  10. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2005
    ..abstract_text> ..
  11. Drug-Induced Liver Injury Network (DILIN)
    Paul Watkins; Fiscal Year: 2008
    ..Finally, we will work diligently to develop and validate a simple and practical web-based instrument that will become the preferred means to establish the diagnosis of DILI. ..
  12. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  13. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2005
    ..abstract_text> ..
  14. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2003
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  15. Michigan Hepatotoxicity Clinical Research Network
    Robert Fontana; Fiscal Year: 2008
    ..A LiverTox website will not only improve worldwide knowledge and awareness of DILI but also potentially enhance recruitment for the DILIN Prospective study and other future initiatives. ..
  16. Midwest Hepatitis B Consortium
    Adrian Di Bisceglie; Fiscal Year: 2008
    ..Finally, we propose studies on Health-Related Quality of Life (HRQOL) using the Hepatitis B Quality of Life instrument, version 1.0, HBQOL v1.0 developed and validated by Dr Fasiha Kanwal, consortium P.I. at the St. Louis VAMC. ..
  17. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2007
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  18. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2008
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  19. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..
  20. Alcohol Dependence in General Medical Settings
    Scott Stewart; Fiscal Year: 2006
    ....
  21. Breast Cancer Prevention and Treatment with Noni juice
    Mian Ying Wang; Fiscal Year: 2007
    ..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
  22. Green Tea Polyphenols: A Novel Approach to IBD
    HELIEH OZ; Fiscal Year: 2004
    ..abstract_text> ..
  23. Michigan Hepatotoxicity Clinical Research Network
    Robert Fontana; Fiscal Year: 2007
    ..abstract_text> ..
  24. Evaluation of a Biomarker for Acetaminophen Toxicity
    Laura James; Fiscal Year: 2005
    ..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
  25. Pediatric Pharmacology Research Unit Network
    Laura James; Fiscal Year: 2008
    ..A well-defined program to educate students as well as experienced health care providers is in place. Ultimately, the primary mission of the PPRU Network, to improve pediatric therapeutics. ..
  26. Cell Culture System for Hepatitis C Virus Genotype 1a
    Adrian Di Bisceglie; Fiscal Year: 2008
    ..The availability of novel LRP and cloning technology will allow us to address this question in lieu of viral genetic heterogeneity. ..
  27. Alcohol Dependence in General Medical Settings
    Scott Stewart; Fiscal Year: 2008
    ....
  28. Effect of ethanol on Kupffer cell/hepatocyte interactions and lipid metabolism
    Suthat Liangpunsakul; Fiscal Year: 2008
    ..By acquiring the knowledge and skills outlined in this proposal, the candidate hopes to fulfill his career goal of becoming a well-trained and funded physician scientist. ..
  29. Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Laura James; Fiscal Year: 2008
    ....
  30. NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Laura James; Fiscal Year: 2004
    ..abstract_text> ..
  31. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2009
    ..It is thus of great interest and importance to understand the mechanism of action leading to liver toxicity so that better therapeutics can be developed to prevent or ameliorate drug-induced liver injury. ..
  32. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2008
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  33. Role of aberrant regulation of organelle stress responses in alcohol-induced live
    Cheng Ji; Fiscal Year: 2009
    ..This research is to understand how alcohol promotes injury processes in the two organelles and how organelle damages contribute to liver disease which will open new avenues for preventing and treating liver disease. ..
  34. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2010
    ..It is thus of great interest and importance to understand the mechanism of action leading to liver toxicity so that better therapeutics can be developed to prevent or ameliorate drug-induced liver injury. ..
  35. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura P James; Fiscal Year: 2010
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  36. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2002
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  37. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  38. Treatment of PTSD in Cardiac Patients
    Eyal Shemesh; Fiscal Year: 2007
    ..We will evaluate the safety as well as the potential benefits of this approach. A full efficacy trial is expected to follow this pilot study if the results are encouraging. ..
  39. Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Laura P James; Fiscal Year: 2010
    ..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
  40. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  41. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2000
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  42. Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Laura James; Fiscal Year: 2009
    ..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
  43. Medication Adherence in Children Who Had a Liver Transplant (MALT)
    Eyal Shemesh; Fiscal Year: 2009
    ..The results will help transplant centers identify these children and improve overall post transplant survival, and will also inform other areas of medicine in which children may not take their medications as prescribed. ..
  44. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 1999
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  45. Phosphatidylethanol as an Alcohol Biomarker in Patients with Liver Disease
    Scott Stewart; Fiscal Year: 2009
    ..Results may provide health care providers with an important tool for detecting heavy drinking, for monitoring response to alcohol treatment, and for early detection of relapse. ..
  46. Phosphatidylethanol as an Alcohol Biomarker in Patients with Liver Disease
    Scott H Stewart; Fiscal Year: 2010
    ..Results may provide health care providers with an important tool for detecting heavy drinking, for monitoring response to alcohol treatment, and for early detection of relapse. ..
  47. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2009
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  48. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2010
    ..Understanding of additive/synergistic effects of HIV PIs and alcohol on the ER stress that worsens liver injury will provide better strategies to improve care for HIV-infected patients. ..
  49. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2007
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. [unreadable] [unreadable]..
  50. HCV-HIV Coinfection: Impact of Immune Dysfunction
    Richard Sterling; Fiscal Year: 2007
    ..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..
  51. Adipose and Fatty Liver in the Metabolic Syndrome
    Jeffrey Schwimmer; Fiscal Year: 2006
    ..abstract_text> ..
  52. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2001
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  53. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2000
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  54. A Multi-Center Study of Acute Liver Failure in Adults
    William Lee; Fiscal Year: 2007
    ....
  55. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2003
    ....
  56. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2002
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  57. UT Southwestern: Clinical Site for the Drug-Induced Liver Injury Network
    William Lee; Fiscal Year: 2008
    ..3) We propose a therapeutic trial using N-acetylcysteine for DILI cases that meet criteria for severe injury approximating Hy Zimmerman's law, that is, an acute illness with attendant jaundice. ..
  58. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2008
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. [unreadable] [unreadable]..
  59. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2003
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  60. North Texas Hepatitis B Consortium: Clinical Site for the Hepatitis B Network
    William Lee; Fiscal Year: 2008
    ....
  61. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  62. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2003
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  63. A Multi-Center Study of Acute Liver Failure in Adults
    William Lee; Fiscal Year: 2008
    ....
  64. PTSD and nonadherence in pediatric transplant patients
    Eyal Shemesh; Fiscal Year: 2005
    ..This proposal will therefore allow the principal investigator to develop into an independent investigator performing clinical research into the phenomenology and treatment of co-morbid psychiatric and medical illness in children. ..
  65. Non-parenteral transmission of hepatitis C
    Chia Wang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  66. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2007
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
  67. MECHANISM OF GLUTATHIONE CONJUGATE DEPENDENT TOXICITY
    Arthur Cooper; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  68. Alcohol Stimulation and Sedation in Binge Drinkers
    Andrea C King; Fiscal Year: 2010
    ..Equally important, the potential protective factors underlying low risk drinking will also be examined. ..
  69. HIV Disease, Drug Abuse, & Nutrient Therapy in Botswana
    Marianna Baum; Fiscal Year: 2007
    ..Since antiretroviral therapies are not readily available to HIV infected adults in most countries in Africa, this study may provide an alternative approach to retard HIV progression. ..
  70. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2007
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
  71. Renal Protection With A1 Adenosine Receptors
    H Lee; Fiscal Year: 2008
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  72. Dietary Fructose and Redox Effects in Pediatric Nonalcoholic Fatty Liver Disease
    Miriam Vos; Fiscal Year: 2008
    ..These studies are designed to lead to improved treatment and prevention of NAFLD in children, thus improving the health of millions of children. ..
  73. Regeneration of the Lower Urinary Tract in Nonhuman Primates
    James Koudy Williams; Fiscal Year: 2010
    ....
  74. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2008
    ..It is thus of great interest and importance to understand the mechanism of action leading to liver toxicity so that better therapeutics can be developed to prevent or ameliorate drug-induced liver injury. ..
  75. Longitudinal Comparative Effectiveness & Safety of Biologics in Autoimmunity
    Jeffrey R Curtis; Fiscal Year: 2010
    ....
  76. Hepatoxicity in an African HIV Treatment Cohort
    Christopher Hoffmann; Fiscal Year: 2008
    ..It will be conducted within a large and on-going ARV cohort established as a collaborative project between a South African industrial conglomerate and Johns Hopkins University. [unreadable] [unreadable]..
  77. Acupuncture to aid post-colectomy recovery in colorectal cancer patients
    Gary Deng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  78. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2002
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  79. VIRAHEP-C Clinical Center
    Anna Lok; Fiscal Year: 2005
    ..abstract_text> ..
  80. NALTREXONE IN DRINKERS SMOKING RESPONSE
    Andrea King; Fiscal Year: 2002
    ..Examining a targeted treatment combining pharmacotherapy and behavioral treatment for this subgroup is of great importance, as alcohol abusers show increased mortality more due to tobacco than alcohol-related illness. ..
  81. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  82. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2001
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
  83. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2001
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  84. Zinc Therapy in Zinc Deficient HIV+ Drug Users
    Marianna Baum; Fiscal Year: 2001
    ....
  85. Proteomics and Biomarkers for Hepatocellular Cancer
    Nezam Afdhal; Fiscal Year: 2004
    ..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
  86. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  87. PROTECTIVE EFFECTS OF ADENOSINE RECEPTOR MODULATION
    H Lee; Fiscal Year: 2003
    ..This, in turn, will contribute to improved therapeutic regimens for the protection of renal function in patients. ..
  88. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
  89. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  90. ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 2003
    ..In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History. ..
  91. HIV Disease, Drug Abuse, & Nutrient Therapy in Botswana
    Marianna Baum; Fiscal Year: 2003
    ..Since antiretroviral therapies are not readily available to HIV infected adults in most countries in Africa, this study may provide an alternative approach to retard HIV progression. ..
  92. Mechanism of renal protection with volatile anesthetics
    H Lee; Fiscal Year: 2009
    ..Our studies will mechanistically advance our understanding of volatile anesthetic-mediated renal tubule protection, leukocyte modulation and improved outcome after renal IR injury. ..
  93. Alcohol Stimulation and Sedation in Binge Drinkers
    Andrea King; Fiscal Year: 2003
    ..abstract_text> ..
  94. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2003
    ..abstract_text> ..
  95. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2008
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..