thymidine phosphorylase

Summary

Summary: The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby liberating thymidine. EC 2.4.2.4.

Top Publications

  1. doi Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways
    Chia Chun Chen
    Graduate Institute of Biomedical Sciences, Chang Gung University, 259, Wen Hwa 1st Road, Kwei Shan, Taoyuan 333, Taiwan
    Cell Signal 22:1132-42. 2010
  2. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
  3. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
  4. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
  5. ncbi 5-fluorouracil: mechanisms of action and clinical strategies
    Daniel B Longley
    Cancer Research Centre, Department of Oncology, Queen s University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Nat Rev Cancer 3:330-8. 2003
  6. ncbi Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
    Anticancer Drugs 19:819-24. 2008
  7. pmc Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase
    E Di Gennaro
    Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, National Cancer Institute Fondazione G, Via M Semmola, Pascale, Napoli 80131, Italy
    Br J Cancer 103:1680-91. 2010
  8. doi Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression
    Keith R Unger
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
    Int J Radiat Oncol Biol Phys 80:1377-82. 2011
  9. pmc Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice
    Misako Haraguchi
    Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
    Mol Cell Biol 22:5212-21. 2002
  10. ncbi Differences and relationships of thymidine phosphorylase expression in tumor-associated macrophages and cancer cells in squamous cell carcinoma of the esophagus
    N Koide
    Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Esophagus 15:67-73. 2002

Research Grants

  1. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2013
  2. Interactions of the angiopoietin and PD-ECGF pathways in tumor angiogenesis
    Edward L Schwartz; Fiscal Year: 2013
  3. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern L Schramm; Fiscal Year: 2010
  4. Mechanisms of thymide phosphorylase angiogenesis
    Edward L Schwartz; Fiscal Year: 2010
  5. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2010
  6. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2005
  7. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2006
  8. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2007
  9. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2006
  10. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2004

Detail Information

Publications249 found, 100 shown here

  1. doi Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways
    Chia Chun Chen
    Graduate Institute of Biomedical Sciences, Chang Gung University, 259, Wen Hwa 1st Road, Kwei Shan, Taoyuan 333, Taiwan
    Cell Signal 22:1132-42. 2010
    High thymidine phosphorylase (TP) expression is significantly correlated with poor prognosis in patients with nasopharyngeal carcinoma (NPC)...
  2. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
    ..weakness of conventional 5-fluorouracil (5-FU) therapy relates to expression of the intracellular enzyme, thymidine phosphorylase (TP)...
  3. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
    ..b>Thymidine phosphorylase (TP, EC 2. 4. 2...
  4. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
    ..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...
  5. ncbi 5-fluorouracil: mechanisms of action and clinical strategies
    Daniel B Longley
    Cancer Research Centre, Department of Oncology, Queen s University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Nat Rev Cancer 3:330-8. 2003
    ..Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy...
  6. ncbi Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
    Anticancer Drugs 19:819-24. 2008
    The objective of this study was to investigate the relationship between the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and the response to capecitabine in patients with advanced/recurrent gastric ..
  7. pmc Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase
    E Di Gennaro
    Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, National Cancer Institute Fondazione G, Via M Semmola, Pascale, Napoli 80131, Italy
    Br J Cancer 103:1680-91. 2010
    ..induce synergistic antitumour effects in combination with capecitabine by modulating the expression of thymidine phosphorylase (TP), a key enzyme in the conversion of capecitabine to 5-florouracil (5-FU), and thymidylate synthase (..
  8. doi Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression
    Keith R Unger
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
    Int J Radiat Oncol Biol Phys 80:1377-82. 2011
    Thymidylate synthase (TS) and thymidine phosphorylase (TP) expression have been shown to be predictors of response to therapy...
  9. pmc Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice
    Misako Haraguchi
    Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
    Mol Cell Biol 22:5212-21. 2002
    b>Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels...
  10. ncbi Differences and relationships of thymidine phosphorylase expression in tumor-associated macrophages and cancer cells in squamous cell carcinoma of the esophagus
    N Koide
    Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Esophagus 15:67-73. 2002
    b>Thymidine phosphorylase (TP), which has been shown to be identical to platelet-derived endothelial cell growth factor, is expressed in tumor-associated macrophages (TAMs) as well as cancer cells...
  11. doi Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer
    C S Boskos
    1st Radiation Oncology Department, Agios Savvas Anticancer Institute, Athens, Greece
    J Surg Oncol 102:408-12. 2010
    To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in ..
  12. doi Synergistic effect of curcumin and cisplatin via down-regulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1)
    Min Shao Tsai
    Molecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
    Mol Pharmacol 80:136-46. 2011
    ..b>Thymidine phosphorylase (TP), an enzyme of the pyrimidine salvage pathway, is considered an attractive therapeutic target, and ..
  13. ncbi Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Res 62:2834-9. 2002
    b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
  14. ncbi Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study
    Miriam Koopman
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, 6500HB Nijmegen, The Netherlands
    Eur J Cancer 45:1999-2006. 2009
    ..several biomarkers [dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), thymidylate synthase (TS) and excision cross-complementing gene (ERCC1)] for their prognostic and ..
  15. doi Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical data
    E Ruckhäberle
    Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
    Eur J Cancer 46:549-57. 2010
    Contrary findings exist according to the prognostic and predictive impact of thymidine phosphorylase (TP) expression in breast cancer...
  16. ncbi Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose
    Yuichi Nakajima
    Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
    Cancer Res 64:1794-801. 2004
    b>Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine...
  17. pmc Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer
    T Yoshikawa
    The Third Department of Surgery, Kanagawa Cancer Center, Yokohama City University, School of Medicine, Japan
    Br J Cancer 79:1145-50. 1999
    Previous studies demonstrated that the immunohistochemical expression of thymidine phosphorylase (dThdPase) was related with distant metastasis and disease progression...
  18. pmc Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency
    Yutaka Nishigaki
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:1913-21. 2003
    ..MNGIE) is an autosomal recessive disorder caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP)...
  19. ncbi Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Pathol 204:562-8. 2004
    ..Response to pre-operative treatment, however, varies significantly. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are thought to be important predictors for the efficiency ..
  20. ncbi Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    Russell D Leek
    Imperial Cancer Research Fund Tumor Pathology Unit, University of Oxford Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU R D L, K L T, F P, H T, L C, K C G
    Cancer Res 62:1326-9. 2002
    ..of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02)...
  21. ncbi Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment
    Masakazu Toi
    Department of Clinical Trials and Research, Tokyo Metropolitan Cancer and Infectious Disease Centre, Komagome Hospital, Tokyo, Japan
    Lancet Oncol 6:158-66. 2005
    b>Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis...
  22. doi Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures
    Giordano Pula
    Cardiovascular Division, King s College London School of Medicine, King s College London, United Kingdom
    Circ Res 104:32-40. 2009
    ..This extensive proteomic analysis revealed the presence of the proangiogenic factor thymidine phosphorylase (TP)...
  23. ncbi Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Hum Pathol 33:213-9. 2002
    ..variables, microvessel count, and expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP)...
  24. pmc Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcin
    S Lee
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, Korea
    Br J Cancer 103:845-51. 2010
    Our purpose was to evaluate thymidine synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementation group 1 (ERCC1) expression as biomarkers for capecitabine and cisplatin (XP) combination chemotherapy in ..
  25. pmc Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine
    Kazumi Uchida
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Cancer 8:386. 2008
    ..Over-expression of ERCC1 correlates with insensitivity to oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity to capecitabine (Xel).
  26. ncbi Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer
    C Andreetta
    Department of Oncology, University Hospital of Udine, Udine, Italy
    Ann Oncol 20:265-71. 2009
    ..that is converted to 5-fluorouracil through several enzymatic steps, the last of which is mediated by thymidine phosphorylase (TP)...
  27. ncbi Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase
    Yukari Harino
    Department of Surgery, Institute of Health Biosciences, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Clin Oncol 13:452-7. 2008
    Angiogenesis plays an important role in tumor growth and metastasis. Thymidine phosphorylase (TP), as well as vascular endothelial growth factor (VEGF), is known to be an angiogenic factor...
  28. pmc The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes
    Kenji Ikuta
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, MuzuhoMizuho ku, Nagoya, 467 8601, Japan
    Arthritis Res Ther 14:R87. 2012
    Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients...
  29. ncbi Localization of thymidine phosphorylase expression in colorectal carcinoma tissues by in situ RT-PCR assay
    Koshi Mimori
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Oncology 62:327-32. 2002
    Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined...
  30. doi Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer
    Sotaro Sadahiro
    Department of Surgery, Tokai University School of Medicine, Kanagawa 259 1193, Japan
    Cancer Chemother Pharmacol 70:285-91. 2012
    ....
  31. ncbi Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma
    Masamichi Yasuno
    Department of Surgical Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyou ku, Tokyo 113 8519, Japan
    Oncol Rep 13:405-12. 2005
    b>Thymidine phosphorylase (TP) is a unique enzyme involved not only in angiogenesis, but in 5-fluorouracil (5-FU) metabolism as well. TP is produced by both tumor and stromal cells...
  32. ncbi Expression of thymidine phosphorylase and VEGF in esophageal squamous cell carcinoma
    Takuma Nomiya
    Department of Radiology, Tohoku University Hospital, 1 1, Seiryo machi, Sendai 980 8574, Japan
    Oncol Rep 15:1497-501. 2006
    ..717 for TP/VEGF[+/- or -/+] group, p=0.005). In conclusion, VEGF and TP expression seems to have a relationship with tumor angiogenesis, and co-expression of TP and VEGF seemed to be one of the unfavorable prognostic factors...
  33. ncbi Importance of thymidine phosphorylase expression at the invasive front of T3 rectal cancer as a prognostic factor
    Kazuhisa Yoshimoto
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Dig Surg 23:331-5. 2006
    Vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) are angiogenic factors...
  34. ncbi Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer
    Peter P Grimminger
    Department of General, Visceral and Tumor Surgery, University of Cologne, Germany
    Clin Lung Cancer 11:328-34. 2010
    Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are key enzymes in the 5-fluorouracil (5-FU) pathway...
  35. doi Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells
    L C Chen
    Chang Gung Molecular Medicine Research Center, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Oncogene 28:1904-15. 2009
    ..nuclear ribonucleoprotein K (hnRNP K) is significantly correlated with the elevated expression of thymidine phosphorylase (TP), and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma (..
  36. ncbi Late-onset MNGIE due to partial loss of thymidine phosphorylase activity
    Ramon Marti
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann Neurol 58:649-52. 2005
    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the gene encoding thymidine phosphorylase (TP)...
  37. ncbi The dual role of thymidine phosphorylase in cancer development and chemotherapy
    Annelies Bronckaers
    Rega Institute for Medical Research, KULeuven, Leuven, Belgium
    Med Res Rev 29:903-53. 2009
    b>Thymidine phosphorylase (TP), also known as "platelet-derived endothelial cell growth factor" (PD-ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers...
  38. ncbi Localization of thymidine phosphorylase in advanced gastric and colorectal cancer
    Michiya Kobayashi
    Department of Surgery, Kochi Medical School, Oko cho, Kohasu, Nankoku, 783 8505 Japan
    J Mol Histol 35:69-74. 2004
    b>Thymidine phosphorylase (TP) is known to be more concentrated in human cancer tissues than in adjacent normal tissue based on findings using enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry...
  39. ncbi The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma
    Shin ichi Aishima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Surg Pathol 10:47-56. 2002
    b>Thymidine phosphorylase (TP), an important regulator of angiogenesis, is correlated with progression, metastasis, and prognosis in various types of tumor...
  40. ncbi Thymidine phosphorylase expressed in macrophages enhances antitumor effect of 5'-deoxy-5-fluorouridine on human colorectal carcinoma cells
    Jimin Zhang
    Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Anticancer Res 23:323-9. 2003
    b>Thymidine phosphorylase (dThdPase) is a key enzyme in the activation of the pro-drugs of 5-fluorouracil (5-FU), 5-deoxy-5-fluorouridine (5'-DFUR) and capecitabine...
  41. ncbi The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes
    Takuma Kusabe
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 25:625-30. 2005
    ..These findings indicate that AuTG and DEX have anti-rheumatic activity, which is mediated via the suppression of GLS production. Neither methotrexate (MTX) nor sulfasalazine (SSZ) had a significant influence on GLS levels in our study...
  42. ncbi Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase
    Philip Reigan
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Bioorg Med Chem Lett 14:5247-50. 2004
    A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity...
  43. ncbi Expression of thymidine phosphorylase by macrophages in colorectal cancer tissues
    Ji min Zhang
    Department of Gastrointestinal Surgery, the Second Hospital of Guangzhou Medical School, Guangzhou 510260, Guangdong Province, China
    World J Gastroenterol 10:545-9. 2004
    To detect the thymidine phosphorylase (dThdPase) expression in human colorectal cancer tissues and cells.
  44. ncbi The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression
    Shin ichi Akiyama
    Department of Molecular Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544
    Cancer Sci 95:851-7. 2004
    b>Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
  45. doi Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE
    N F Moran
    Neurology, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, CT1 3NG, UK
    Neurology 71:686-8. 2008
  46. ncbi [Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells]
    Ji min Zhang
    Department of Gastrointestinal Surgery, The Second Hospital, Guangzhou Medicine School, Guangzhou 510260, China
    Zhonghua Yi Xue Za Zhi 84:718-24. 2004
    To detect the thymidine phosphorylase (dThdPase) expression in colorectal carcinoma tissue, and clarify whether dThdPase expressed in macrophage-like cell lines, and monocytes from human peripheral blood can modulate the anticancer ..
  47. doi The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism
    Harsh V Jain
    Department of Chemistry, University at Buffalo, Buffalo, NY 14260, United States
    Bioorg Med Chem Lett 20:1648-51. 2010
    The design and synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU), a potent inhibitor of thymidine phosphorylase (TP) with K(i)-values of 11nM (ecTP) and 17nM (hTP), are described...
  48. ncbi Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages
    H Goto
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 61:469-73. 2001
    b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to platelet-derived endothelial cell growth factor...
  49. pmc Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival
    M I Koukourakis
    Department of Radiotherapy Oncology and Saint Nikolas Histopathology Unit, University Hospital of Iraklion, Crete, Greece
    Br J Cancer 77:1696-703. 1998
    ..The P-GF.44C MAb was used to assess thymidine phosphorylase (TP) reactivity in cancer cells, stromal fibroblasts and macrophages...
  50. doi Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer
    Tomohiko Miyatani
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
    Cancer Lett 318:199-205. 2012
    ..However, there are few to be available in the clinical setting. Thymidine phosphorylase inhibitor (TPI) regulates the phosphorolysis of thymidine to thymine and 2-deoxy-d-ribose-1-phosphate ..
  51. ncbi Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE
    J Torres-Torronteras
    Laboratori of Neuromuscular and Mitochondrial Disorders, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gene Ther 18:795-806. 2011
    ..MNGIE) is an autosomal recessive disorder caused by mutations in the TYMP gene, which encodes thymidine phosphorylase (TP)...
  52. pmc Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP)
    John R Grierson
    Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington, USA
    Nucleosides Nucleotides Nucleic Acids 29:49-54. 2010
    ..5-fluoro analog of TPI (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]uracil), a potent inhibitor of human thymidine phosphorylase (TP), has an IC(50) in a range that might allow to use it labeled for imaging of TP expression in vivo...
  53. ncbi The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist
    Sandra Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Mol Cancer Ther 11:817-29. 2012
    5'-O-Tritylinosine (KIN59) is an allosteric inhibitor of the angiogenic enzyme thymidine phosphorylase. Previous observations showed the capacity of KIN59 to abrogate thymidine phosphorylase-induced as well as developmental angiogenesis ..
  54. ncbi Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor
    K Asai
    Department of Bioregulation Research, Nagoya City University Medical School, Japan
    J Biol Chem 267:20311-6. 1992
    ..These data indicate that gliostatin/PD-ECGF may play important roles on development and regeneration of the central nervous system and may also involve the induction of angiogenesis for the formation of blood brain barrier...
  55. doi Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine
    Jen Chung Ko
    Department of Internal Medicine, Hsinchu Hospital, Department of Health, The Executive Yuan, Taiwan
    Biochem Pharmacol 81:680-90. 2011
    b>Thymidine phosphorylase (TP) is the rate-limiting enzyme for the activation of capecitabine (pro-drug of fluorouracil), and as a useful predictor of tumor response to capecitabine-based chemotherapy...
  56. ncbi Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers
    Laura Libernini
    Division of Pediatric Neurology, Department of Pediatrics, Child Neurology and Psychiatry, La Sapienza University of Rome, Rome, Italy
    Neuropediatrics 43:201-8. 2012
    ..recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP)...
  57. ncbi Angiogenic factor
    T Furukawa
    Nature 356:668. 1992
  58. ncbi Pd-ECGF positivity correlates with better survival, while iNOS has no predictive value for cervical carcinomas treated with radiotherapy
    Kuniyuki Oka
    Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 57:217-21. 2003
    Platelet-derived endothelial cell growth factor (PD-ECGF), which has angiogenic activity, is identical to thymidine phosphorylase. Tumor vascularization is considered to be an important prognostic factor...
  59. ncbi Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue
    M Zimovjanova
    Department of Oncology, General Teaching Hospital, 12880 Prague, Czech Republic
    Neoplasma 52:208-10. 2005
    Thymidylate synthase [TS], thymidine phosphorylase [TP] and dihydropyrimidine dehydrogenase [DPD] play the essential role in the activation and catabolism of the fluoropyrimidines used in cancer therapy...
  60. ncbi A case report of papilla Vater carcinoma showing positive expression of thymidine phosphorylase
    Shinji Osada
    Second Department of Surgery, Gifu University School of Medicine, Gifu City, Japan
    Hepatogastroenterology 51:375-7. 2004
    ..The immunohistochemical stain showed the strong expression of thymidine phosphorylase in the tumor tissue and also in the normal biliary tract, despite positive p53 cells being undetected in ..
  61. ncbi Gliostatin/thymidine phosphorylase-regulated vascular endothelial growth-factor production in human fibroblast-like synoviocytes
    Tomohiro Tanikawa
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho chou, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 27:553-9. 2007
    Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities...
  62. ncbi Late-onset MNGIE without peripheral neuropathy due to incomplete loss of thymidine phosphorylase activity
    Roberto Massa
    Department of Neurosciences, University of Rome Tor Vergata and IRCCS Fondazione S Lucia, Via Montpellier 1, I 00135 Rome, Italy
    Neuromuscul Disord 19:837-40. 2009
    ..Mutations in the TYMP/ECGF1 gene cause a loss of thymidine phosphorylase catalytic activity, disrupting the homeostasis of intramitochondrial nucleotide pool...
  63. pmc Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
    R D Leek
    Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
    Br J Cancer 77:2246-51. 1998
    ..The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to promote tumour angiogenesis...
  64. ncbi The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine
    Tomohiro Nishina
    Department of Medical Oncology, National Shikoku Cancer Center, 13 Horinouchi, Matsuyama, Ehime 790 0007, Japan
    Eur J Cancer 40:1566-71. 2004
    The aim of this work was to determine whether intratumour contents of thymidine phosphorylase (TP), which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil, and dihydropyrimidine dehydrogenase (DPD), which degrades 5-..
  65. pmc Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors
    I V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Br J Cancer 104:1185-92. 2011
    b>Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis...
  66. ncbi Neoangiogenesis in patients with gastric carcinoma in relation to the expression of vascular endothelial growth factor and thymidine phosphorylase
    Shunichi Tsujitani
    Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
    Anticancer Res 24:1853-9. 2004
    ..the prognostic significance of microvessel density and the relationship between the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), and angiogenesis in patients with gastric carcinoma.
  67. doi FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes
    Takaya Yamagami
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 31:903-9. 2011
    Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities. The purpose of this study was to determine the inhibitory effects of FK506 (tacrolimus) on GLS production in rheumatoid arthritis (RA)...
  68. ncbi Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells
    Michiel de Bruin
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Mol Pharmacol 66:1054-60. 2004
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) and interleukin-8 (IL-8) are angiogenic factors produced by tumor infiltrating macrophages...
  69. ncbi Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors
    Takenori Hayashi
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 55:403-6. 2008
    We evaluated a relationship between postoperative recurrence and thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) expression at the invasive front of T3 rectal cancer.
  70. ncbi Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells
    H Kanyama
    Department of Surgery II, Osaka University Medical School, Suita
    Jpn J Cancer Res 90:454-9. 1999
    b>Thymidine phosphorylase (dThdPase) is an enzyme that converts 5'-deoxy-5-fluorouridine (5'DFUR) to the toxic substance 5-fluorouracil (5-FU); it is also known to be a platelet-derived endothelial cell growth factor...
  71. pmc Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis
    D P Stevenson
    Diagnostics Research Unit, Department of Obstetrics and Gynecology, King s College School of Medicine and Dentistry, London, United Kingdom
    Am J Pathol 152:1641-6. 1998
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is associated with angiogenesis and the progression of human breast and ovarian cancers...
  72. ncbi Increased blood-brain barrier permeability with thymidine phosphorylase deficiency
    K Szigeti
    Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    Ann Neurol 56:881-6. 2004
    ..neurogastrointestinal encephalomyopathy is an autosomal recessive multisystemic disorder caused by thymidine phosphorylase deficiency...
  73. ncbi Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3
    Kylie A Hotchkiss
    Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Biol Chem 278:19272-9. 2003
    b>Thymidine phosphorylase is an angiogenic factor that is frequently overexpressed in solid tumors, in rheumatoid arthritis, and in response to inflammatory cytokines...
  74. ncbi Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder
    I Nishino
    Columbia University College of Physicians and Surgeons, Department of Neurology, 630 West 168 Street, P and S 4 443, New York, NY 10032, USA
    Science 283:689-92. 1999
    ..of 12 MNGIE probands revealed homozygous or compound-heterozygous mutations in the gene specifying thymidine phosphorylase (TP), located on chromosome 22q13.32-qter...
  75. ncbi Significance of thymidine phosphorylase in HCC with chronic liver disease for long-term postoperative recurrence
    Takahiro Ezaki
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    J Surg Oncol 83:173-9; discussion 179. 2003
    Little is known about the significance of thymidine phosphorylase (TP) levels in HCC. The authors investigated the TP activity of HCC and adjacent normal liver tissue in 70 HCC patients, and the prognostic significance of the TP levels.
  76. ncbi Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival
    S Fujioka
    Department of Surgery 1, University Hospital, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer 92:1788-97. 2001
    ..Recently, the usefulness of intratumoral microvessel density (IMD) and expression of several angiogenic factors as prognostic indicators have been demonstrated in several human solid tumors...
  77. pmc Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms
    Shiladitya Sengupta
    Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD
    Br J Pharmacol 139:219-31. 2003
    1 Thymidine phosphorylase (TP) is elevated in the plasma of cancer patients, and has been implicated in pathophysiological angiogenesis. However, the downstream signals underlying this implication remain obscure...
  78. pmc Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma
    N S Brown
    Molecular Angiogenesis Group, Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Br J Cancer 92:1696-701. 2005
    Elevated thymidine phosphorylase has been shown to correlate with increased angiogenesis and poor prognosis in many cancers including transitional cell carcinoma of the bladder...
  79. ncbi Angiogenic factor thymidine phosphorylase increases cancer cell invasion activity in patients with gastric adenocarcinoma
    Eun Jeong Yu
    Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
    Mol Cancer Res 6:1554-66. 2008
    We investigated the biological role of thymidine phosphorylase (TP), an angiogenic factor, in gastric cancer cell migration and invasion and explored a therapeutic approach for high TP-expressing tumors using TP enzymatic inhibitor (TPI) ..
  80. ncbi Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines
    Olaf H Temmink
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Biochem Cell Biol 39:565-75. 2007
    b>Thymidine phosphorylase (TP) and uridine phosphorylase (UP) are often upregulated in solid tumors and catalyze the phosphorolysis of natural (deoxy)nucleosides and a wide variety of fluorinated pyrimidine nucleosides...
  81. ncbi Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling
    M J Currie
    Anatomical Pathology, Canterbury Health, Christchurch Hospital, Christchurch, New Zealand
    Clin Cancer Res 7:918-27. 2001
    ..016) and a significant inverse correlation between Ang-1 and thymidine phosphorylase expression (P = 0.01)...
  82. ncbi Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver
    T Komatsu
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Clin Cancer Res 7:675-81. 2001
    ..Because the conversion of tegafur into 5-FU has also been reported to be catalyzed by cytosolic thymidine phosphorylase (dThdPase), the involvement of human liver microsomes and cytosol and individual differences in 5-FU ..
  83. doi Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)
    A Bronckaers
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 78:231-40. 2009
    b>Thymidine phosphorylase (TP) is a catabolic enzyme in thymidine metabolism that is frequently upregulated in many solid tumors. Elevated TP levels are associated with tumor angiogenesis, metastasis and poor prognosis...
  84. ncbi Influence of platelet-derived endothelial cell growth factor/thymidine phosphorylase on the cell cycle in head and neck squamous cell carcinoma in vitro
    Hideki Igawa
    Department of Otorhinolaryngology, Fukui Medical University, 23 Shimoaizuki, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    Oncol Rep 10:967-71. 2003
    ..was isolated as an endothelial mitogen from platelets and demonstrated to have angiogenic activity and thymidine phosphorylase (TP) activity...
  85. ncbi Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
    Kotaro Miyake
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima, 770 8503 Japan
    Int J Clin Oncol 12:111-9. 2007
    b>Thymidine phosphorylase (TP), orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD) are important enzymes related to the metabolism of 5-fluorouracil and its derivatives...
  86. ncbi 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9
    Yuichi Nakajima
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Int J Cancer 119:1710-6. 2006
    b>Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor...
  87. ncbi The role of vascular endothelial growth factor-A (VEGF-A) and platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in Paget's disease of the vulva and breast
    Patricia E Ellis
    Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, UK
    Anticancer Res 22:857-61. 2002
    ..Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) has also been shown to stimulate angiogenesis.
  88. ncbi Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
    Philip Reigan
    School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Eur J Med Chem 43:1248-60. 2008
    b>Thymidine phosphorylase (TP) is over-expressed in various tumour types and plays an important role in tumour angiogenesis, growth, invasion and metastasis...
  89. ncbi Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients
    M Kurosumi
    Department of Clinical Pathology, Saitama Cancer Center, Ina machi, Kitaadachi gun, Saitama 362 0806, Japan
    Oncol Rep 7:945-8. 2000
    For the purpose of demonstrating possible effects of docetaxel on thymidine phosphorylase (TP) activity in human breast carcinoma, we examined breast carcinoma tissues pre- and post-administration of docetaxel, by an immunohistochemical ..
  90. doi Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells
    I V Bijnsdorp
    VU University Medical Center, Department Medical Oncology, De Boelelaan 1117 CCA 1 42, 1081 HV Amsterdam, The Netherlands
    Biochem Pharmacol 80:786-92. 2010
    b>Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis...
  91. ncbi Prognostic role of angiogenesis and its correlations with thymidine phosphorylase and p53 expression in ductal adenocarcinoma of the pancreas
    Ma Jinfeng
    Department of Gastroenterology and General Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Hepatogastroenterology 54:1635-40. 2007
    ..little information is available regarding the prognostic role of angiogenesis and its correlation with Thymidine phosphorylase (dThdPase) in ductal adenocarcinoma of the pancreas...
  92. ncbi Immunohistochemical localization of thymidine phosphorylase in gastric cancer: is there a role of the differential expression in tumor cells and associated stromal cells?
    Theodore Liakakos
    Third Department of Surgery, University of Athens, Attikon, University General Hospital, 1 Rimini St, Haidari, 12462 Athens, Greece
    Anticancer Res 26:3899-903. 2006
    The aim of this study was to investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in gastric carcinoma cells and tumor-associated stromal cells.
  93. ncbi Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in cervical intraepithelial neoplasia
    Shigeyuki Isaka
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 0025, Japan
    Int J Oncol 21:281-7. 2002
    ..Platelet-derived endothelial cell growth factor (PD-ECGF)/thymidine phosphorylase (TP) has been identified as such an angiogenic factor...
  94. ncbi Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin
    I V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 29:482-7. 2010
    b>Thymidine phosphorylase (TP) catalyzes the phosphorylytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. The latter may be involved in the angiogenic stimulation of TP...
  95. ncbi Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts
    Teiji Takechi
    Cancer Research Laboratory, Product Lifecycle Management Department, Taiho Pharmaceutical Co, Ltd, 1 27 Kanda Nishikicho, Chiyoda ku, Tokyo 101 8444, Japan
    Oncol Rep 14:33-9. 2005
    ..We investigated tumor thymidylate synthase content, dihydropyrimidine dehydrogenase (DPD) activity, thymidine phosphorylase (TP) activity and orotate phosphoribosyl transferase activity in seven human lung tumor xenografts and ..
  96. ncbi The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
    Sandra Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:29598-605. 2004
    b>Thymidine phosphorylase (TPase) catalyzes the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases...
  97. ncbi Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues
    Masao Chujo
    Department of Oncological Science, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Oncol Rep 16:777-80. 2006
    b>Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are the major catabolic enzymes of 5-FU...
  98. doi Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer
    Su Jin Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Cancer Chemother Pharmacol 68:743-51. 2011
    The primary purpose of this study was to evaluate the role of thymidylate synthase (TS) and thymidine phosphorylase (TP) as biomarkers to predict clinical outcomes of capecitabine monotherapy in patients with anthracycline- and taxane-..
  99. ncbi Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 370:220-4. 2008
    An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia...
  100. ncbi Molecular basis for the involvement of thymidine phosphorylase in cancer invasion
    Takenari Gotanda
    Department of Urology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Int J Mol Med 17:1085-91. 2006
    b>Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), has been implicated in bladder cancer angiogenesis and invasion. However, the molecular basis of its role in invasion remains unclear...
  101. ncbi Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents
    Hei Cheul Jeung
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Biochem Pharmacol 70:13-21. 2005
    We investigated the ability of thymidine phosphorylase (TP) to confer cancer cells resistance to MIA (microtubule-interfering agents)-induced apoptosis...

Research Grants70

  1. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2013
    ..MNGIE) is a fatal autosomal recessive disease caused by mutations in the TYMP gene encoding thymidine phosphorylase (TP)...
  2. Interactions of the angiopoietin and PD-ECGF pathways in tumor angiogenesis
    Edward L Schwartz; Fiscal Year: 2013
    ..include a novel, highly specific, orally available small molecule inhibito of the angiogenic factor thymidine phosphorylase (TP) which we have synthesized, and two highly specific peptibodies which neutralize the angiogenic ..
  3. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern L Schramm; Fiscal Year: 2010
    ..Human thymidine phosphorylase is a prototype for kinetically difficult TS analyses...
  4. Mechanisms of thymide phosphorylase angiogenesis
    Edward L Schwartz; Fiscal Year: 2010
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  5. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2010
    ..MNGIE) is a fatal autosomal recessive disease caused by mutations in the TYMP gene encoding thymidine phosphorylase (TP)...
  6. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2005
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  7. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2006
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  8. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2007
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  9. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2006
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  10. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2004
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  11. Non-Immunogenic ADEPT: Human Enzymes & Delivery Vehicles
    Sherie Morrison; Fiscal Year: 2007
    ..Specifically, we will use human thymidine phosphorylase (hTP), currently a target of prodrug therapy because it is overexpressed in some human tumors, and we ..
  12. Non-Immunogenic ADEPT: Human Enzymes & Delivery Vehicles
    Sherie Morrison; Fiscal Year: 2006
    ..Specifically, we will use human thymidine phosphorylase (hTP), currently a target of prodrug therapy because it is overexpressed in some human tumors, and we ..
  13. Non-Immunogenic ADEPT: Human Enzymes & Delivery Vehicles
    Sherie Morrison; Fiscal Year: 2005
    ..Specifically, we will use human thymidine phosphorylase (hTP), currently a target of prodrug therapy because it is overexpressed in some human tumors, and we ..
  14. Nucleoside phosphorylases: Role in wound healing in skin
    JOHN HAGGERTY; Fiscal Year: 2000
    b>Thymidine phosphorylase is a catabolic enzyme whose activity has been studied extensively in human epidermal keratinocytes. Thymidine phosphorylase is identical to the angiogenic agent platelet derived- endothelial cell growth factor...
  15. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2007
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  16. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2009
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  17. 3-D STRUCTURES OF URIDINE & THYMIDINE PHOSPHORYLASES
    Steven Ealick; Fiscal Year: 1990
    The objective is to determine the three-dimensional structures of uridine phosphorylase and thymidine phosphorylase. The pyrimidine phosphorylases may be responsible for the degradation of certain nucleoside analogs of potential ..
  18. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2006
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  19. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2005
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  20. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2001
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  21. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2004
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  22. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2003
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  23. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2002
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  24. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2004
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  25. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2000
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  26. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2001
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  27. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2003
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  28. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2002
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  29. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2004
    ..b>Thymidine phosphorylase (TP) has been recently found to be an angiogenic factor, an observation that was based on its identity to ..
  30. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2002
    ..b>Thymidine phosphorylase (TP) has been recently found to be an angiogenic factor, an observation that was based on its identity to ..
  31. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2001
    ..b>Thymidine phosphorylase (TP) has been recently found to be an angiogenic factor, an observation that was based on its identity to ..
  32. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2003
    ..b>Thymidine phosphorylase (TP) has been recently found to be an angiogenic factor, an observation that was based on its identity to ..
  33. ADENOSINE DEAMINASE DEFICIENCY: GENETICS AND IMMUNOLOGY
    Dennis Carson; Fiscal Year: 1980
    ..g., thymidine phosphorylase, 4) to use our newfound knowledge of the biochemistry of immunodeficiency disease for the development of ..
  34. CELLULAR INTERACTIONS OF 5 FLUOROURACIL AND INTERFERON
    Edward Schwartz; Fiscal Year: 2000
    ..activity was identified: the induction of expression by IFN, both in vitro and in vivo, of the enzyme thymidine phosphorylase (TP)...
  35. CELLULAR INTERACTIONS OF 5 FLUOROURACIL AND INTERFERON
    Edward Schwartz; Fiscal Year: 1999
    ..activity was identified: the induction of expression by IFN, both in vitro and in vivo, of the enzyme thymidine phosphorylase (TP)...
  36. CELLULAR INTERACTIONS OF 5 FLUOROURACIL AND INTERFERON
    Edward Schwartz; Fiscal Year: 2000
    ..activity was identified: the induction of expression by IFN, both in vitro and in vivo, of the enzyme thymidine phosphorylase (TP)...
  37. ANTIANGIOGENESIS BY THYMIDINE PHOSPHORYLASE INHIBITORS
    George Wright; Fiscal Year: 1999
    ..One angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF), is identical with thymidine phosphorylase (TP), an enzyme of thymidine metabolism and homeostasis...
  38. MOLECULAR PROGNOSTIC INDICATORS IN COLORECTAL CANCER
    Leonard Saltz; Fiscal Year: 2000
    ..Further data suggest that low expression of both thymidine phosphorylase and dihydropyrimidine dehydrogenase are consistent with responsiveness to FU/LV, while high expression of ..
  39. MOLECULAR PROGNOSTIC INDICATORS IN COLORECTAL CANCER
    Leonard Saltz; Fiscal Year: 1999
    ..Further data suggest that low expression of both thymidine phosphorylase and dihydropyrimidine dehydrogenase are consistent with responsiveness to FU/LV, while high expression of ..
  40. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2005
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  41. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2007
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  42. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2006
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  43. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2006
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  44. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2003
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  45. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2004
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  46. Molecular Pathogenesis of MNGIE
    Michio Hirano; Fiscal Year: 2003
    ..32-qter and subsequently identified loss-of-function mutations in the thymidine phosphorylase (TP) gene as the cause of the disorder...
  47. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern Schramm; Fiscal Year: 2009
    ..Human thymidine phosphorylase is a prototype for kinetically difficult TS analyses...
  48. dUTPase As A Prognostic Marker in Colon Cancer
    Robert Ladner; Fiscal Year: 2002
    ..expression with other known prognostic markers of colorectal cancer including, thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and p53...
  49. dUTPase As A Prognostic Marker in Colon Cancer
    Robert Ladner; Fiscal Year: 2003
    ..expression with other known prognostic markers of colorectal cancer including, thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and p53...
  50. Studies of the Pathogenic Mechanism of HIV
    Miles Cloyd; Fiscal Year: 2003
    ..e., are activated and are undergoing "activation-induced cell death") or are thymidine phosphorylase+ (i.e...
  51. Studies of the Pathogenic Mechanism of HIV
    Miles Cloyd; Fiscal Year: 2002
    ..e., are activated and are undergoing "activation-induced cell death") or are thymidine phosphorylase+ (i.e...
  52. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  53. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2006
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  54. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2005
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  55. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2007
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  56. Biomodulation of capecitabine by docetaxel in non-small*
    MIGUEL VILLALONA; Fiscal Year: 2004
    ..This synergy is believed due to upregulation of the enzyme thymidine phosphorylase (TP), which is responsible for the preferential tumor activation of capecitabine...
  57. Biomodulation of capecitabine by docetaxel in non-small*
    MIGUEL VILLALONA; Fiscal Year: 2005
    ..This synergy is believed due to upregulation of the enzyme thymidine phosphorylase (TP), which is responsible for the preferential tumor activation of capecitabine...
  58. PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES IN CHEMOTHERAPY
    SHIH HSI CHU; Fiscal Year: 1990
    ..2. Biological testing of these new agents as inhibitors of uridine phosphorylase and, where indicated, thymidine phosphorylase, as transport inhibitors, anti-tumor agents and potentiators both in vitro and in vivo, and as tools for ..
  59. Phase l study of 131 I-HuA33 with oral capecitabine in*
    Andrew Scott; Fiscal Year: 2006
    ..The final conversion to 5-FU is by thymidine phosphorylase, which is much more active in colorectal tumor tissue compared to normal tissues...
  60. Phase l study of 131 I-HuA33 with oral capecitabine
    Andrew Scott; Fiscal Year: 2005
    ..The final conversion to 5-FU is by thymidine phosphorylase, which is much more active in colorectal tumor tissue compared to normal tissues...
  61. MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    Peter Danenberg; Fiscal Year: 1999
    ..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
  62. MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    Peter Danenberg; Fiscal Year: 2001
    ..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
  63. MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    Peter Danenberg; Fiscal Year: 2000
    ..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
  64. ENZYME MARKER FOR HEMATOPOIETIC CELLS
    Sohaib Khan; Fiscal Year: 1980
    b>Thymidine phosphorylase activity will be measured in leukemic cell lines of T- and B-cell origin. The enzyme activity will also be followed in human leukemias...