thymidine phosphorylase

Summary

Summary: The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby liberating thymidine. EC 2.4.2.4.

Top Publications

  1. ncbi Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
    R D Leek
    Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
    Br J Cancer 77:2246-51. 1998
  2. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
  3. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
  4. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
  5. ncbi 5-fluorouracil: mechanisms of action and clinical strategies
    Daniel B Longley
    Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Nat Rev Cancer 3:330-8. 2003
  6. ncbi Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
    Cancer Res 62:2834-9. 2002
  7. ncbi Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer
    T Yoshikawa
    The Third Department of Surgery, Kanagawa Cancer Center, Yokohama City University, School of Medicine, Japan
    Br J Cancer 79:1145-50. 1999
  8. ncbi Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study
    Miriam Koopman
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, 6500HB Nijmegen, The Netherlands
    Eur J Cancer 45:1999-2006. 2009
  9. ncbi Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose
    Yuichi Nakajima
    Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
    Cancer Res 64:1794-801. 2004
  10. ncbi Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcin
    S Lee
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, Korea
    Br J Cancer 103:845-51. 2010

Research Grants

  1. Non-Immunogenic ADEPT: Human Enzymes & Delivery Vehicles
    Sherie Morrison; Fiscal Year: 2007
  2. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2010
  3. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2005
  4. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2007
  5. Mechanisms of thymide phosphorylase angiogenesis
    Edward L Schwartz; Fiscal Year: 2010
  6. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2009
  7. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2007
  8. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2004
  9. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2004
  10. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2007

Detail Information

Publications206 found, 100 shown here

  1. ncbi Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
    R D Leek
    Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
    Br J Cancer 77:2246-51. 1998
    ..The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to promote tumour angiogenesis...
  2. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
    ..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...
  3. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
    ..weakness of conventional 5-fluorouracil (5-FU) therapy relates to expression of the intracellular enzyme, thymidine phosphorylase (TP)...
  4. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
    ..b>Thymidine phosphorylase (TP, EC 2. 4. 2...
  5. ncbi 5-fluorouracil: mechanisms of action and clinical strategies
    Daniel B Longley
    Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Nat Rev Cancer 3:330-8. 2003
    ..Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy...
  6. ncbi Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
    Cancer Res 62:2834-9. 2002
    b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
  7. ncbi Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer
    T Yoshikawa
    The Third Department of Surgery, Kanagawa Cancer Center, Yokohama City University, School of Medicine, Japan
    Br J Cancer 79:1145-50. 1999
    Previous studies demonstrated that the immunohistochemical expression of thymidine phosphorylase (dThdPase) was related with distant metastasis and disease progression...
  8. ncbi Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study
    Miriam Koopman
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, 6500HB Nijmegen, The Netherlands
    Eur J Cancer 45:1999-2006. 2009
    ..several biomarkers [dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), thymidylate synthase (TS) and excision cross-complementing gene (ERCC1)] for their prognostic and ..
  9. ncbi Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose
    Yuichi Nakajima
    Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
    Cancer Res 64:1794-801. 2004
    b>Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine...
  10. ncbi Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcin
    S Lee
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, Korea
    Br J Cancer 103:845-51. 2010
    Our purpose was to evaluate thymidine synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementation group 1 (ERCC1) expression as biomarkers for capecitabine and cisplatin (XP) combination chemotherapy in ..
  11. ncbi Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical data
    E Ruckhäberle
    Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
    Eur J Cancer 46:549-57. 2010
    Contrary findings exist according to the prognostic and predictive impact of thymidine phosphorylase (TP) expression in breast cancer...
  12. ncbi Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency
    Yutaka Nishigaki
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:1913-21. 2003
    ..MNGIE) is an autosomal recessive disorder caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP)...
  13. ncbi Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Pathol 204:562-8. 2004
    ..Response to pre-operative treatment, however, varies significantly. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are thought to be important predictors for the efficiency ..
  14. ncbi Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures
    Giordano Pula
    Cardiovascular Division, King s College London School of Medicine, King s College London, United Kingdom
    Circ Res 104:32-40. 2009
    ..This extensive proteomic analysis revealed the presence of the proangiogenic factor thymidine phosphorylase (TP)...
  15. ncbi Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine
    Kazumi Uchida
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Cancer 8:386. 2008
    ..Over-expression of ERCC1 correlates with insensitivity to oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity to capecitabine (Xel).
  16. ncbi Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer
    C Andreetta
    Department of Oncology, University Hospital of Udine, Udine, Italy
    Ann Oncol 20:265-71. 2009
    ..that is converted to 5-fluorouracil through several enzymatic steps, the last of which is mediated by thymidine phosphorylase (TP)...
  17. ncbi Immunohistochemical localization of thymidine phosphorylase in gastric cancer: is there a role of the differential expression in tumor cells and associated stromal cells?
    Theodore Liakakos
    Third Department of Surgery, University of Athens, Attikon, University General Hospital, 1 Rimini St, Haidari, 12462 Athens, Greece
    Anticancer Res 26:3899-903. 2006
    The aim of this study was to investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in gastric carcinoma cells and tumor-associated stromal cells.
  18. ncbi Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling
    M J Currie
    Anatomical Pathology, Canterbury Health, Christchurch Hospital, Christchurch, New Zealand
    Clin Cancer Res 7:918-27. 2001
    ..016) and a significant inverse correlation between Ang-1 and thymidine phosphorylase expression (P = 0.01)...
  19. ncbi Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver
    T Komatsu
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Clin Cancer Res 7:675-81. 2001
    ..Because the conversion of tegafur into 5-FU has also been reported to be catalyzed by cytosolic thymidine phosphorylase (dThdPase), the involvement of human liver microsomes and cytosol and individual differences in 5-FU ..
  20. ncbi Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines
    Olaf H Temmink
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Biochem Cell Biol 39:565-75. 2007
    b>Thymidine phosphorylase (TP) and uridine phosphorylase (UP) are often upregulated in solid tumors and catalyze the phosphorolysis of natural (deoxy)nucleosides and a wide variety of fluorinated pyrimidine nucleosides...
  21. ncbi Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma
    N S Brown
    Molecular Angiogenesis Group, Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Br J Cancer 92:1696-701. 2005
    Elevated thymidine phosphorylase has been shown to correlate with increased angiogenesis and poor prognosis in many cancers including transitional cell carcinoma of the bladder...
  22. ncbi Increased blood-brain barrier permeability with thymidine phosphorylase deficiency
    K Szigeti
    Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA
    Ann Neurol 56:881-6. 2004
    ..neurogastrointestinal encephalomyopathy is an autosomal recessive multisystemic disorder caused by thymidine phosphorylase deficiency...
  23. ncbi 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9
    Yuichi Nakajima
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan
    Int J Cancer 119:1710-6. 2006
    b>Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor...
  24. ncbi Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells
    Michiel de Bruin
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Mol Pharmacol 66:1054-60. 2004
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) and interleukin-8 (IL-8) are angiogenic factors produced by tumor infiltrating macrophages...
  25. ncbi The role of vascular endothelial growth factor-A (VEGF-A) and platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in Paget's disease of the vulva and breast
    Patricia E Ellis
    Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, UK
    Anticancer Res 22:857-61. 2002
    ..Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) has also been shown to stimulate angiogenesis...
  26. ncbi Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3
    Kylie A Hotchkiss
    Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Biol Chem 278:19272-9. 2003
    b>Thymidine phosphorylase is an angiogenic factor that is frequently overexpressed in solid tumors, in rheumatoid arthritis, and in response to inflammatory cytokines...
  27. ncbi Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms
    Shiladitya Sengupta
    Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD
    Br J Pharmacol 139:219-31. 2003
    1 Thymidine phosphorylase (TP) is elevated in the plasma of cancer patients, and has been implicated in pathophysiological angiogenesis. However, the downstream signals underlying this implication remain obscure...
  28. ncbi Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in cervical intraepithelial neoplasia
    Shigeyuki Isaka
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 0025, Japan
    Int J Oncol 21:281-7. 2002
    ..Platelet-derived endothelial cell growth factor (PD-ECGF)/thymidine phosphorylase (TP) has been identified as such an angiogenic factor...
  29. ncbi Influence of platelet-derived endothelial cell growth factor/thymidine phosphorylase on the cell cycle in head and neck squamous cell carcinoma in vitro
    Hideki Igawa
    Department of Otorhinolaryngology, Fukui Medical University, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan
    Oncol Rep 10:967-71. 2003
    ..was isolated as an endothelial mitogen from platelets and demonstrated to have angiogenic activity and thymidine phosphorylase (TP) activity...
  30. ncbi Significance of thymidine phosphorylase in HCC with chronic liver disease for long-term postoperative recurrence
    Takahiro Ezaki
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    J Surg Oncol 83:173-9; discussion 179. 2003
    Little is known about the significance of thymidine phosphorylase (TP) levels in HCC. The authors investigated the TP activity of HCC and adjacent normal liver tissue in 70 HCC patients, and the prognostic significance of the TP levels.
  31. ncbi Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
    Kotaro Miyake
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima, 770 8503 Japan
    Int J Clin Oncol 12:111-9. 2007
    b>Thymidine phosphorylase (TP), orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD) are important enzymes related to the metabolism of 5-fluorouracil and its derivatives...
  32. ncbi Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
    Philip Reigan
    School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Eur J Med Chem 43:1248-60. 2008
    b>Thymidine phosphorylase (TP) is over-expressed in various tumour types and plays an important role in tumour angiogenesis, growth, invasion and metastasis...
  33. ncbi Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder
    I Nishino
    Columbia University College of Physicians and Surgeons, Department of Neurology, 630 West 168 Street, P and S 4 443, New York, NY 10032, USA
    Science 283:689-92. 1999
    ..of 12 MNGIE probands revealed homozygous or compound-heterozygous mutations in the gene specifying thymidine phosphorylase (TP), located on chromosome 22q13.32-qter...
  34. ncbi Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival
    S Fujioka
    Department of Surgery 1, University Hospital, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Cancer 92:1788-97. 2001
    ..Recently, the usefulness of intratumoral microvessel density (IMD) and expression of several angiogenic factors as prognostic indicators have been demonstrated in several human solid tumors...
  35. ncbi Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors
    Takenori Hayashi
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 55:403-6. 2008
    We evaluated a relationship between postoperative recurrence and thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) expression at the invasive front of T3 rectal cancer.
  36. ncbi Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis
    D P Stevenson
    Diagnostics Research Unit, Department of Obstetrics and Gynecology, King s College School of Medicine and Dentistry, London, United Kingdom
    Am J Pathol 152:1641-6. 1998
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is associated with angiogenesis and the progression of human breast and ovarian cancers...
  37. ncbi Angiogenic factor thymidine phosphorylase increases cancer cell invasion activity in patients with gastric adenocarcinoma
    Eun Jeong Yu
    Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
    Mol Cancer Res 6:1554-66. 2008
    We investigated the biological role of thymidine phosphorylase (TP), an angiogenic factor, in gastric cancer cell migration and invasion and explored a therapeutic approach for high TP-expressing tumors using TP enzymatic inhibitor (TPI) ..
  38. ncbi Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)
    A Bronckaers
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 78:231-40. 2009
    b>Thymidine phosphorylase (TP) is a catabolic enzyme in thymidine metabolism that is frequently upregulated in many solid tumors. Elevated TP levels are associated with tumor angiogenesis, metastasis and poor prognosis...
  39. ncbi Prognostic role of angiogenesis and its correlations with thymidine phosphorylase and p53 expression in ductal adenocarcinoma of the pancreas
    Ma Jinfeng
    Department of Gastroenterology and General Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Hepatogastroenterology 54:1635-40. 2007
    ..little information is available regarding the prognostic role of angiogenesis and its correlation with Thymidine phosphorylase (dThdPase) in ductal adenocarcinoma of the pancreas...
  40. ncbi Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients
    M Kurosumi
    Department of Clinical Pathology, Saitama Cancer Center, Ina machi, Kitaadachi gun, Saitama 362 0806, Japan
    Oncol Rep 7:945-8. 2000
    For the purpose of demonstrating possible effects of docetaxel on thymidine phosphorylase (TP) activity in human breast carcinoma, we examined breast carcinoma tissues pre- and post-administration of docetaxel, by an immunohistochemical ..
  41. ncbi Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells
    I V Bijnsdorp
    VU University Medical Center, Department Medical Oncology, De Boelelaan 1117 CCA 1 42, 1081 HV Amsterdam, The Netherlands
    Biochem Pharmacol 80:786-92. 2010
    b>Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis...
  42. ncbi Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin
    I V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 29:482-7. 2010
    b>Thymidine phosphorylase (TP) catalyzes the phosphorylytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. The latter may be involved in the angiogenic stimulation of TP...
  43. ncbi Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells
    H Kanyama
    Department of Surgery II, Osaka University Medical School, Suita
    Jpn J Cancer Res 90:454-9. 1999
    b>Thymidine phosphorylase (dThdPase) is an enzyme that converts 5'-deoxy-5-fluorouridine (5'DFUR) to the toxic substance 5-fluorouracil (5-FU); it is also known to be a platelet-derived endothelial cell growth factor...
  44. ncbi Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents
    Hei-Cheul Jeung
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan
    Biochem Pharmacol 70:13-21. 2005
    We investigated the ability of thymidine phosphorylase (TP) to confer cancer cells resistance to MIA (microtubule-interfering agents)-induced apoptosis...
  45. ncbi Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuou ku, Chiba, Japan, 260 8677
    Cancer 94:1947-54. 2002
    b>Thymidine phosphorylase (dThdPase), which also is referred to as platelet-derived endothelial cell growth factor, is a potent inducer of angiogenesis in malignant tumors...
  46. ncbi Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Hum Pathol 33:213-9. 2002
    ..variables, microvessel count, and expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP)...
  47. ncbi The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
    Sandra Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:29598-605. 2004
    b>Thymidine phosphorylase (TPase) catalyzes the reversible phosphorolysis of pyrimidine deoxynucleosides to 2-deoxy-d-ribose-1-phosphate and their respective pyrimidine bases...
  48. ncbi Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer
    Akihiko Kawahara
    Department of Diagnostic Pathology, Kurume University Hospital, Kurume 830 0011, Japan
    Oncol Rep 24:405-15. 2010
    b>Thymidine phosphorylase (TP), an enzyme catalyzing the reversible phospholysis of thymidine, deoxyuridine and their analogs at their respective bases and 2-deoxyribose-1-phosphate, thus promoting angiogenesis, is often expressed in ..
  49. ncbi The predictive and therapeutic value of thymidine phosphorylase and dihydropyrimidine dehydrogenase in capecitabine (Xeloda)-based chemotherapy for head and neck cancer
    Koichiro Saito
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 119:82-8. 2009
    To evaluate whether two molecular biomarkers, thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD), could be clinically useful in predicting and improving the chemotherapeutic outcome of the oral fluoropyrimidine ..
  50. ncbi Thymidine phosphorylase suppresses Fas-induced apoptotic signal transduction independent of its enzymatic activity
    Shin ichiro Mori
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Biochem Biophys Res Commun 295:300-5. 2002
    b>Thymidine phosphorylase (TP) has chemotactic and angiogenic activities resulting from its enzymatic activity in vitro, and it also promotes tumor growth and inhibits apoptosis in vivo...
  51. ncbi Radiation-induced thymidine phosphorylase upregulation in rectal cancer is mediated by tumor-associated macrophages by monocyte chemoattractant protein-1 from cancer cells
    Tae Dong Kim
    Department of Biochemistry, Chungnam National University College of Medicine, Daejon, Korea
    Int J Radiat Oncol Biol Phys 73:853-60. 2009
    The mechanisms of thymidine phosphorylase (TP) regulation induced by radiation therapy (XRT) in various tumors are poorly understood. We investigated the effect and mechanisms of preoperative XRT on TP expression in rectal cancer tissues.
  52. ncbi Thymidine phosphorylase expression in tumour cells and tumour response to capecitabine plus docetaxel chemotherapy in non-small cell lung cancer
    J-Y Han
    Research Institute and Hospital, National Cancer Centre, 809 Madu1-dong, Goyang-si, Gyeonggi-do, 411-769, Korea
    J Clin Pathol 58:650-4. 2005
    BACKGROUND: Thymidine phosphorylase (TP) is the key enzyme for capecitabine activation in tumour cells...
  53. ncbi Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts
    Teiji Takechi
    Cancer Research Laboratory, Product Lifecycle Management Department, Taiho Pharmaceutical Co, Ltd, 1 27 Kanda Nishikicho, Chiyoda ku, Tokyo 101 8444, Japan
    Oncol Rep 14:33-9. 2005
    ..We investigated tumor thymidylate synthase content, dihydropyrimidine dehydrogenase (DPD) activity, thymidine phosphorylase (TP) activity and orotate phosphoribosyl transferase activity in seven human lung tumor xenografts and ..
  54. ncbi The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Int J Clin Oncol 11:297-302. 2006
    b>Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor, has been implicated in the angiogenesis of bladder cancer...
  55. ncbi Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer
    Su Jin Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Cancer Chemother Pharmacol 68:743-51. 2011
    The primary purpose of this study was to evaluate the role of thymidylate synthase (TS) and thymidine phosphorylase (TP) as biomarkers to predict clinical outcomes of capecitabine monotherapy in patients with anthracycline- and taxane-..
  56. ncbi Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap
    Haiyan Lu
    Department of Oncology, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Clin Cancer Res 15:5136-44. 2009
    ..Platelet-derived endothelial cell growth factor is identical to the enzyme thymidine phosphorylase (TP), and unlike other angiogenic factors, the proangiogenic actions of TP are dependent on its enzyme ..
  57. ncbi Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 370:220-4. 2008
    An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia...
  58. ncbi Thymidine phosphorylase expression causes both the increase of intratumoral microvessels and decrease of apoptosis in human esophageal carcinomas
    E Okamoto
    First Department of Pathology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan
    Pathol Int 51:158-64. 2001
    b>Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor, is expressed at higher levels in tumor tissues compared to the adjacent normal tissues in a variety of human carcinomas...
  59. ncbi Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues
    Masao Chujo
    Department of Oncological Science, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Oncol Rep 16:777-80. 2006
    b>Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are the major catabolic enzymes of 5-FU...
  60. ncbi Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy
    Christiane Jakob
    Institute for Pathology, University of Technology, Dresden, Germany
    Am J Surg Pathol 30:1169-74. 2006
    ..Furthermore, the prognostic value of thymidylate synthase (TS)-gene, thymidine phosphorylase (TP)-gene, and dihydropyrimidine dehydrogenase (DPD)-gene expression after neoadjuvant CT/RT was ..
  61. ncbi The expression of thymidine phosphorylase suppresses spontaneous apoptosis of cancer cells in esophageal squamous cell carcinoma
    M Ikeguchi
    Department of Surgery I, Faculty of Medicine, Tottori University, Yonago, Japan
    Pathobiology 69:36-43. 2001
    b>Thymidine phosphorylase (TP) is an enzyme which converts thymidine to thymine. TP is expressed in a variety of human carcinomas and is known to be a potent angiogenic factor...
  62. ncbi Molecular basis for the involvement of thymidine phosphorylase in cancer invasion
    Takenari Gotanda
    Department of Urology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Int J Mol Med 17:1085-91. 2006
    b>Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), has been implicated in bladder cancer angiogenesis and invasion. However, the molecular basis of its role in invasion remains unclear...
  63. ncbi Expression of thymidine phosphorylase as an effect prediction factor for uterine cervical squamous cell carcinoma after radiotherapy: an immunohistochemical study
    M Nakashima
    Department of Obstetrics and Gynecology, Toyama Prefectural Central Hospital, 2 2 78 nishinagae Toyama Shi, Toyama, Japan
    Int J Gynecol Cancer 16:1309-13. 2006
    ..were investigated in association with immunohistochemical expression of an angiogenic factor, thymidine phosphorylase (TP)...
  64. ncbi Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Oncol Rep 14:1223-30. 2005
    ..the drugs, such as dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), thymidine phosphorylase (TP), and thymidylate synthase (TS)...
  65. ncbi Heterogeneous ribonucleoprotein k and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma
    Lih Chyang Chen
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    Clin Cancer Res 14:3807-13. 2008
    Heterogeneous ribonucleoprotein K (hnRNP K) regulates thymidine phosphorylase (TP) mRNA stability...
  66. ncbi Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy
    Sandra Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Biochem Pharmacol 74:1555-67. 2007
    b>Thymidine phosphorylase (TP) is a key enzyme in the pyrimidine nucleoside salvage pathway, but it also recognizes and inactivates various anti-cancer chemotherapeutic agents...
  67. ncbi Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma
    Jongkonnee Thanasai
    Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    World J Gastroenterol 16:1631-8. 2010
    To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA).
  68. ncbi Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
    R Soong
    Oncology Research Institute, National University of Singapore, Singapore
    Ann Oncol 19:915-9. 2008
    Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-..
  69. ncbi The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior
    I V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 27:681-91. 2008
    Platelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high TP expression at tumor sites is correlated with tumor growth, induction of angiogenesis, and metastasis...
  70. ncbi A role of thymidine phosphorylase and P53 tissue protein expression in biology of endometrial cancer
    A Mazurek
    Department of Pathophysiology of Pregnancy, Medical University of Bialystok, Sklodowskiej 24a, Bialystok, Poland
    Neoplasma 55:261-5. 2008
    ..b>Thymidine phosphorylase is one of the most important angiogenic factors, which is connected with tumor expansion and invasiveness...
  71. ncbi Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomas
    A Giatromanolaki
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Surg Oncol 29:879-83. 2003
    ..To investigate the angiogenic and prognostic role of vascular endothelial growth factor (VEGF) in operable gallbladder carcinomas...
  72. ncbi Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design
    Kamel El Omari
    Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Biochem J 399:199-204. 2006
    HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism...
  73. ncbi Thymidine phosphorylase inhibits apoptosis induced by cisplatin
    Ryuji Ikeda
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890, Japan
    Biochem Biophys Res Commun 301:358-63. 2003
    An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia...
  74. ncbi Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity
    Vincenzo Guarcello
    Department of Pharmacology and Toxicology, Comprehensive Cancer Center, Center for AIDS Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Chemother Pharmacol 62:85-96. 2008
    b>Thymidine phosphorylase (TP, EC 2.4.2.4) activity varies in different human cancer cell lines. Nevertheless, little is known about the regulatory mechanisms of TP expression in such cancers...
  75. ncbi 5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis
    Hidekazu Kuramochi
    University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Int J Cancer 119:522-6. 2006
    Gene expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) have been shown to be associated with response to 5-fluorouracil-based ..
  76. ncbi Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase
    Christian Cole
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    J Med Chem 46:207-9. 2003
    b>Thymidine phosphorylase (TP) is an angiogenic growth factor and a target for anticancer drug design. Molecular modeling suggested that 2'-aminoimidazolylmethyluracils would be potent inhibitors of TP...
  77. ncbi Thymidine phosphorylase expression in tumor-infiltrating macrophages may be correlated with poor prognosis in uterine endometrial cancer
    Yoshiko Tanaka
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Pathol 33:1105-13. 2002
    Expression of thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor, in several types of malignant tumors has been associated with angiogenesis and an unfavorable prognosis...
  78. ncbi Clinicopathological and prognostic significance of thymidine phosphorylase and proliferating cell nuclear antigen in gastric carcinoma
    S Konno
    Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishioku, Arakawaku, 116, Tokyo, Japan
    Cancer Lett 166:103-11. 2001
    We have reported that thymidine phosphorylase (dThdPase) is identical to platelet derived-endothelial cell growth factor and that it has an angiogenic activity in vitro and in human carcinoma tissues as well as gastric carcinoma...
  79. ncbi The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma
    H Saito
    First Department of Surgery, Tottori University School of Medicine, Yonago, Japan
    Br J Cancer 81:484-9. 1999
    The expression of thymidine phosphorylase (TP) and the density of microvessel in advanced gastric carcinoma were examined by immunohistochemistry to evaluate the significance of TP...
  80. ncbi Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    Russell D Leek
    Imperial Cancer Research Fund Tumor Pathology Unit, University of Oxford Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU [R. D. L, K. L. T, F. P, H. T, L. C, K. C. G
    Cancer Res 62:1326-9. 2002
    ..of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02)...
  81. ncbi Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma
    K Maeda
    First Department of Surgery, Osaka City University Medical School, Japan
    Br J Cancer 73:884-8. 1996
    ..Recently, it was reported that thymidine phosphorylase (dThdPase) is identical to PD-ECGF...
  82. ncbi Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA
    T Morita
    Department of Urology, Jichi Medical School, Tochigi, Japan
    Int J Cancer 92:451-6. 2001
    The purpose of the present study was to examine directly the role of thymidine phosphorylase (TP) in the sensitivity of renal cell carcinoma (RCC) to a novel fluoropyrimidine carbamate, capecitabine...
  83. ncbi Prognostic and predictive value of thymidine phosphorylase activity in early-stage breast cancer patients
    Takeshi Tominaga
    Breast Cancer Center, Toyosu Hospital, Showa University School of Medicine, Koto ku, Tokyo, Japan
    Clin Breast Cancer 3:55-64. 2002
    ..b>Thymidine phosphorylase (TP) converts 5'-deoxy-5-fluorouridine (5'-DFUR), an intermediate metabolite of capecitabine, to 5-FU...
  84. ncbi Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models
    K Fujimoto-Ouchi
    Oncology, Nippon Roche Research Center, Kamakura, Kanagawa, Japan
    Clin Cancer Res 7:1079-86. 2001
    ..One possible explanation for the synergy is that docetaxel up-regulates tumor levels of thymidine phosphorylase, the enzyme essential for the activation of capecitabine and 5'-dFUrd to 5-fluorouracil...
  85. ncbi Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors
    M M Asgari
    Department of Dermatology, Yale University, New Haven, Connecticut, USA
    J Cutan Pathol 26:287-94. 1999
    b>Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TPase/PD-ECGF) is a catabolic enzyme that has been shown to be chemotactic for endothelial cells in vitro and angiogenic in vivo...
  86. ncbi The activity of thymidine phosphorylase in the uterine myomas and the myometrium in perimenopausal women
    E Miszczak Zaborska
    Department of Biochemistry, , Poland
    Z Naturforsch C 52:850-4. 1997
    The activity of thymidine phosphorylase (dThdPase) in the myometrium and uterine myomas has been investigated in perimenopausal women...
  87. ncbi Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas
    Y Maehara
    Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Cancer 66:156-61. 1990
    ..As 5-FU is incorporated into tumor cells and is metabolized actively to 5-FU nucleotides in squamous cell carcinoma tissues, at almost the same level seen in adenocarcinoma tissues, this drug should have a wide clinical application...
  88. ncbi Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells
    K Usuki
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Biochim Biophys Acta 1222:411-4. 1994
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is a 90 kDa protein consisting of two non-covalently associated subunits. In addition to the previously identified 1...
  89. ncbi Role of thymidine phosphorylase in biomodulation of fluoropyrimidines
    T Morita
    Department of Urology, Jichi Medical School, Tochigi, Japan
    Curr Pharm Biotechnol 2:257-67. 2001
    b>Thymidine phosphorylase (TP) is a key enzyme in the activating pathway of 5'DFUR and capecitabine. On the other hand, TP is identical to platelet-derived endothelial cell growth factor (PD-ECGF) which is known to be an angiogenic factor...
  90. ncbi Thymidine phosphorylase expression in endometrial carcinomas
    E Sivridis
    Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Clin Exp Metastasis 17:445-50. 1999
    b>Thymidine phosphorylase (TP) is a potent angiogenic molecule shown to induce endothelial cell migration and proliferation. We investigated the expression of TP in a series of 156 endometrial carcinomas, using immunohistochemical methods...
  91. ncbi Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast
    K Engels
    Department of Cellular Science, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, U K
    J Pathol 182:414-20. 1997
    ..Platelet-derived endothelial cell growth factor, now known to be thymidine phosphorylase (TP), is a candidate for initiating one of these pathways, since it is important in remodelling the ..
  92. ncbi Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
    A V Patterson
    ICRF Clinical Oncology Unit, University of Oxford, John Radcliffe Hospital, UK
    Br J Cancer 72:669-75. 1995
    Platelet-derived endothelial cell growth factor (PD-ECGF) is identical to human thymidine phosphorylase (dThdPase)...
  93. ncbi Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis
    E Sivridis
    Department of Pathology, Democritus University of Thrace, PO Box 128, Alexandroupolis 68100, Greece
    Br J Cancer 86:1465-71. 2002
    b>Thymidine phosphorylase is an angiogenic factor primarily expressed by cancer cells, stromal cells and tumour-associated macrophages in many human malignancies...
  94. ncbi Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway
    Wataru Ichikawa
    Department of General and Digestive Surgery, Saitama Medical School, 38 Moro-Hongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan
    Gastric Cancer 9:145-55. 2006
    ..The gene expressions of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase are discussed in relation to the efficacy of fluoropyrimidine ..
  95. ncbi Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer
    Neal J Meropol
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 24:4069-77. 2006
    ..therapy for patients with metastatic colorectal cancer (mCRC), and to describe the association of expression of thymidine phosphorylase (TP), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) with antitumor activity.
  96. ncbi Thymidine phosphorylase and capecitabine: a predictive marker for therapy selection?
    BERT H O'NEIL
    J Clin Oncol 24:4051-3. 2006
  97. ncbi Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
    Anticancer Drugs 19:819-24. 2008
    The objective of this study was to investigate the relationship between the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and the response to capecitabine in patients with advanced/recurrent gastric ..
  98. ncbi Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients
    Federica Amatori
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Pharmacogenet Genomics 16:809-16. 2006
    OBJECTIVE: To compare thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) gene polymorphism and expression in colorectal cancer (CRC), and normal mucosa in chemotherapy-naïve patients...
  99. ncbi An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed
    Claire L Graham Cole
    Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Cancer Chemother Pharmacol 59:197-206. 2007
    ..Since thymidine phosphorylase (TP) depletes Thd, the potential for tumour-selective depletion of Thd using antibody-mediated delivery ..
  100. ncbi Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma
    I Kocakova
    Clinic of Comprehensive Cancer Care, Laboratory of Predictive Oncology, Dept of Clin and Exp Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Neoplasma 54:447-53. 2007
    ..of preoperative capecitabine and radiotherapy treatment on the levels of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) mRNAs in rectal carcinoma...
  101. ncbi Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines
    T Ando
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Dis Esophagus 21:15-20. 2008
    ..Gene expression of 5-FU metabolic enzymes such as thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT), has recently ..

Research Grants65

  1. Non-Immunogenic ADEPT: Human Enzymes & Delivery Vehicles
    Sherie Morrison; Fiscal Year: 2007
    ..Specifically, we will use human thymidine phosphorylase (hTP), currently a target of prodrug therapy because it is overexpressed in some human tumors, and we ..
  2. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2010
    ..MNGIE) is a fatal autosomal recessive disease caused by mutations in the TYMP gene encoding thymidine phosphorylase (TP)...
  3. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2005
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  4. Role of Uridine Phosphorylase in Cancer Treatment
    Giuseppe Pizzorno; Fiscal Year: 2007
    ..A second phosphorolytic activity present in mammalian cells, thymidine phosphorylase (TPase), is known to contribute to some of UPase functions, therefore limiting the disruption of uridine ..
  5. Mechanisms of thymide phosphorylase angiogenesis
    Edward L Schwartz; Fiscal Year: 2010
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  6. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2009
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  7. Mechanisms of thymide phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2007
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  8. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2004
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  9. Mechanisms of thymidine phosphorylase angiogenesis
    Edward Schwartz; Fiscal Year: 2004
    ..b>Thymidine phosphorylase (TP) has been recently found to be an angiogenic factor, an observation that was based on its identity to ..
  10. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2007
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  11. dUTPase As A Prognostic Marker in Colon Cancer
    Robert Ladner; Fiscal Year: 2003
    ..expression with other known prognostic markers of colorectal cancer including, thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and p53...
  12. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern L Schramm; Fiscal Year: 2010
    ..Human thymidine phosphorylase is a prototype for kinetically difficult TS analyses...
  13. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern Schramm; Fiscal Year: 2009
    ..Human thymidine phosphorylase is a prototype for kinetically difficult TS analyses...
  14. Studies of the Pathogenic Mechanism of HIV
    Miles Cloyd; Fiscal Year: 2003
    ..e., are activated and are undergoing "activation-induced cell death") or are thymidine phosphorylase+ (i.e...
  15. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2007
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  16. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  17. Biomodulation of capecitabine by docetaxel in non-small*
    MIGUEL VILLALONA; Fiscal Year: 2005
    ..This synergy is believed due to upregulation of the enzyme thymidine phosphorylase (TP), which is responsible for the preferential tumor activation of capecitabine...
  18. MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    Peter Danenberg; Fiscal Year: 2001
    ..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
  19. Phase l study of 131 I-HuA33 with oral capecitabine in*
    Andrew Scott; Fiscal Year: 2006
    ..The final conversion to 5-FU is by thymidine phosphorylase, which is much more active in colorectal tumor tissue compared to normal tissues...