thymidine phosphorylase

Summary

Summary: The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby liberating thymidine. EC 2.4.2.4.

Top Publications

  1. ncbi Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells
    L C Chen
    Chang Gung Molecular Medicine Research Center, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Oncogene 28:1904-15. 2009
  2. ncbi Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma
    Girolamo Ranieri
    Clinical and Experimental Oncology Laboratory, National Cancer Institute, I 70126 Bari, Italy
    Int J Oncol 21:1317-23. 2002
  3. ncbi A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients
    G Ranieri
    Department of Experimental Oncology, Unit of Interventional Radiology, Department of Critical Area and Surgery National Cancer Institute of Bari, Bari, Italy
    J Cell Mol Med 11:362-8. 2007
  4. ncbi The dual role of thymidine phosphorylase in cancer development and chemotherapy
    Annelies Bronckaers
    Rega Institute for Medical Research, KULeuven, Leuven, Belgium
    Med Res Rev 29:903-53. 2009
  5. pmc Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    A Giatromanolaki
    Department of Pathology, Democritus University of Thrace, P O Box 128, Alexandroupolis 68100, Greece
    Br J Cancer 85:881-90. 2001
  6. ncbi Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Oncol Rep 14:1223-30. 2005
  7. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
  8. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
  9. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
  10. ncbi Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures
    Giordano Pula
    Cardiovascular Division, King s College London School of Medicine, King s College London, United Kingdom
    Circ Res 104:32-40. 2009

Research Grants

Detail Information

Publications272 found, 100 shown here

  1. ncbi Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells
    L C Chen
    Chang Gung Molecular Medicine Research Center, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
    Oncogene 28:1904-15. 2009
    ..nuclear ribonucleoprotein K (hnRNP K) is significantly correlated with the elevated expression of thymidine phosphorylase (TP), and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma (..
  2. ncbi Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma
    Girolamo Ranieri
    Clinical and Experimental Oncology Laboratory, National Cancer Institute, I 70126 Bari, Italy
    Int J Oncol 21:1317-23. 2002
    ..and progression of oral cancer, we investigated microvessel density (mVd), mast cell density (mCd) and thymidine phosphorylase (TP) expression in a series of 50 patients with T1-3 N0-1 M0 oral squamous carcinoma (OSC) and 21 ..
  3. ncbi A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients
    G Ranieri
    Department of Experimental Oncology, Unit of Interventional Radiology, Department of Critical Area and Surgery National Cancer Institute of Bari, Bari, Italy
    J Cell Mol Med 11:362-8. 2007
    ..We hypothesized a role for TP in oropharyngeal tumourigenesis and 5-FU activation in the adjuvant setting of OSC patients...
  4. ncbi The dual role of thymidine phosphorylase in cancer development and chemotherapy
    Annelies Bronckaers
    Rega Institute for Medical Research, KULeuven, Leuven, Belgium
    Med Res Rev 29:903-53. 2009
    b>Thymidine phosphorylase (TP), also known as "platelet-derived endothelial cell growth factor" (PD-ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers...
  5. pmc Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    A Giatromanolaki
    Department of Pathology, Democritus University of Thrace, P O Box 128, Alexandroupolis 68100, Greece
    Br J Cancer 85:881-90. 2001
    ..Targeting the HIF pathway may prove of importance in the treatment of NSCLC...
  6. ncbi Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer
    Shingo Kamoshida
    Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Oncol Rep 14:1223-30. 2005
    ..the drugs, such as dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), thymidine phosphorylase (TP), and thymidylate synthase (TS)...
  7. ncbi Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    Hendrik Seeliger
    Department of Surgery, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:1843-52. 2004
    ..weakness of conventional 5-fluorouracil (5-FU) therapy relates to expression of the intracellular enzyme, thymidine phosphorylase (TP)...
  8. ncbi Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
    ..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...
  9. ncbi 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
    Yuichi Nakajima
    Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
    Anticancer Agents Med Chem 9:239-45. 2009
    ..b>Thymidine phosphorylase (TP, EC 2. 4. 2...
  10. ncbi Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures
    Giordano Pula
    Cardiovascular Division, King s College London School of Medicine, King s College London, United Kingdom
    Circ Res 104:32-40. 2009
    ..This extensive proteomic analysis revealed the presence of the proangiogenic factor thymidine phosphorylase (TP)...
  11. ncbi 5-fluorouracil: mechanisms of action and clinical strategies
    Daniel B Longley
    Cancer Research Centre, Department of Oncology, Queen s University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Nat Rev Cancer 3:330-8. 2003
    ..Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy...
  12. ncbi Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    Russell D Leek
    Imperial Cancer Research Fund Tumor Pathology Unit, University of Oxford Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU R D L, K L T, F P, H T, L C, K C G
    Cancer Res 62:1326-9. 2002
    ..of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02)...
  13. ncbi Thymidine phosphorylase mutations cause instability of mitochondrial DNA
    Michio Hirano
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P and S 4 443, New York, NY 10032, USA
    Gene 354:152-6. 2005
    ..This disorder is caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP) a cytosolic enzyme...
  14. ncbi Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients
    Rudolf Napieralski
    Department of Pathology, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 11:3025-31. 2005
    ..We evaluated the expression of seven therapy-related genes to predict the clinical outcome of advanced gastric cancer patients treated with a neoadjuvant chemotherapeutic protocol...
  15. ncbi Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells
    Jen Chung Ko
    Department of Internal Medicine, Hsinchu Hospital, Chiayi, Taiwan
    J Pharmacol Exp Ther 338:184-94. 2011
    ..TS and thymidine phosphorylase (TP) are key enzymes of the pyrimidine salvage pathway...
  16. ncbi Heterogeneous ribonucleoprotein k and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma
    Lih Chyang Chen
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    Clin Cancer Res 14:3807-13. 2008
    Heterogeneous ribonucleoprotein K (hnRNP K) regulates thymidine phosphorylase (TP) mRNA stability...
  17. ncbi Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine
    Jen Chung Ko
    Department of Internal Medicine, Hsinchu Hospital, Department of Health, The Executive Yuan, Taiwan
    Biochem Pharmacol 81:680-90. 2011
    b>Thymidine phosphorylase (TP) is the rate-limiting enzyme for the activation of capecitabine (pro-drug of fluorouracil), and as a useful predictor of tumor response to capecitabine-based chemotherapy...
  18. ncbi The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression
    Shin ichi Akiyama
    Department of Molecular Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544
    Cancer Sci 95:851-7. 2004
    b>Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
  19. ncbi Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment
    Masakazu Toi
    Department of Clinical Trials and Research, Tokyo Metropolitan Cancer and Infectious Disease Centre, Komagome Hospital, Tokyo, Japan
    Lancet Oncol 6:158-66. 2005
    b>Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis...
  20. ncbi Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE
    J Torres-Torronteras
    Laboratori of Neuromuscular and Mitochondrial Disorders, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gene Ther 18:795-806. 2011
    ..MNGIE) is an autosomal recessive disorder caused by mutations in the TYMP gene, which encodes thymidine phosphorylase (TP)...
  21. ncbi Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways
    Chia Chun Chen
    Graduate Institute of Biomedical Sciences, Chang Gung University, 259, Wen Hwa 1st Road, Kwei Shan, Taoyuan 333, Taiwan
    Cell Signal 22:1132-42. 2010
    High thymidine phosphorylase (TP) expression is significantly correlated with poor prognosis in patients with nasopharyngeal carcinoma (NPC)...
  22. ncbi Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression
    Keith R Unger
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
    Int J Radiat Oncol Biol Phys 80:1377-82. 2011
    Thymidylate synthase (TS) and thymidine phosphorylase (TP) expression have been shown to be predictors of response to therapy...
  23. ncbi Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer
    C S Boskos
    1st Radiation Oncology Department, Agios Savvas Anticancer Institute, Athens, Greece
    J Surg Oncol 102:408-12. 2010
    To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in ..
  24. pmc Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice
    Misako Haraguchi
    Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
    Mol Cell Biol 22:5212-21. 2002
    b>Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels...
  25. pmc Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase
    E Di Gennaro
    Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, National Cancer Institute Fondazione G, Via M Semmola, Pascale, Napoli 80131, Italy
    Br J Cancer 103:1680-91. 2010
    ..induce synergistic antitumour effects in combination with capecitabine by modulating the expression of thymidine phosphorylase (TP), a key enzyme in the conversion of capecitabine to 5-florouracil (5-FU), and thymidylate synthase (..
  26. ncbi Synergistic effect of curcumin and cisplatin via down-regulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1)
    Min Shao Tsai
    Molecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
    Mol Pharmacol 80:136-46. 2011
    ..b>Thymidine phosphorylase (TP), an enzyme of the pyrimidine salvage pathway, is considered an attractive therapeutic target, and ..
  27. ncbi Differences and relationships of thymidine phosphorylase expression in tumor-associated macrophages and cancer cells in squamous cell carcinoma of the esophagus
    N Koide
    Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Esophagus 15:67-73. 2002
    b>Thymidine phosphorylase (TP), which has been shown to be identical to platelet-derived endothelial cell growth factor, is expressed in tumor-associated macrophages (TAMs) as well as cancer cells...
  28. ncbi Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study
    Miriam Koopman
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, 6500HB Nijmegen, The Netherlands
    Eur J Cancer 45:1999-2006. 2009
    ..several biomarkers [dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), thymidylate synthase (TS) and excision cross-complementing gene (ERCC1)] for their prognostic and ..
  29. pmc Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer
    T Yoshikawa
    The Third Department of Surgery, Kanagawa Cancer Center, Yokohama City University, School of Medicine, Japan
    Br J Cancer 79:1145-50. 1999
    Previous studies demonstrated that the immunohistochemical expression of thymidine phosphorylase (dThdPase) was related with distant metastasis and disease progression...
  30. ncbi Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical data
    E Ruckhäberle
    Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
    Eur J Cancer 46:549-57. 2010
    Contrary findings exist according to the prognostic and predictive impact of thymidine phosphorylase (TP) expression in breast cancer...
  31. ncbi Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Res 62:2834-9. 2002
    b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
  32. ncbi Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose
    Yuichi Nakajima
    Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
    Cancer Res 64:1794-801. 2004
    b>Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine...
  33. pmc Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency
    Yutaka Nishigaki
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:1913-21. 2003
    ..MNGIE) is an autosomal recessive disorder caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP)...
  34. ncbi Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Pathol 204:562-8. 2004
    ..Response to pre-operative treatment, however, varies significantly. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are thought to be important predictors for the efficiency ..
  35. pmc Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival
    M I Koukourakis
    Department of Radiotherapy Oncology and Saint Nikolas Histopathology Unit, University Hospital of Iraklion, Crete, Greece
    Br J Cancer 77:1696-703. 1998
    ..The P-GF.44C MAb was used to assess thymidine phosphorylase (TP) reactivity in cancer cells, stromal fibroblasts and macrophages...
  36. ncbi Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancer
    Elisabeth H Slager
    Department of Hematology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 107:4954-60. 2006
    ..polymorphism (SNP) in the angiogenic endothelial-cell growth factor-1 (ECGF1) gene also known as thymidine phosphorylase. The SNP leads to an Arg-to-His substitution in an alternatively translated peptide that is recognized by ..
  37. pmc Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcin
    S Lee
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, Korea
    Br J Cancer 103:845-51. 2010
    Our purpose was to evaluate thymidine synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementation group 1 (ERCC1) expression as biomarkers for capecitabine and cisplatin (XP) combination chemotherapy in ..
  38. ncbi Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase
    Ritsuto Fujiwaki
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Hum Pathol 33:213-9. 2002
    ..variables, microvessel count, and expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP)...
  39. pmc Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine
    Kazumi Uchida
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Cancer 8:386. 2008
    ..Over-expression of ERCC1 correlates with insensitivity to oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity to capecitabine (Xel).
  40. ncbi Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer
    C Andreetta
    Department of Oncology, University Hospital of Udine, Udine, Italy
    Ann Oncol 20:265-71. 2009
    ..that is converted to 5-fluorouracil through several enzymatic steps, the last of which is mediated by thymidine phosphorylase (TP)...
  41. ncbi Neoadjuvant docetaxel and capecitabine and the use of thymidine phosphorylase as a predictive biomarker in breast cancer
    Rachel M Layman
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0848, USA
    Clin Cancer Res 13:4092-7. 2007
    b>Thymidine phosphorylase (TP) induction by docetaxel is a proposed mechanism for the observed preclinical synergy of docetaxel and capecitabine (DC)...
  42. ncbi Prognostic significance of thymidine phosphorylase and p53 co-expression in esophageal squamous cell carcinoma
    Oota Makoto
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Oncol Rep 9:23-8. 2002
    This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas...
  43. ncbi Nucleophilic participation in the transition state for human thymidine phosphorylase
    Matthew R Birck
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue Bronx, New York 10461, USA
    J Am Chem Soc 126:2447-53. 2004
    Recombinant human thymidine phosphorylase catalyzes the reaction of arsenate with thymidine to form thymine and 2-deoxyribose 1-arsenate, which rapidly decomposes to 2-deoxyribose and inorganic arsenate...
  44. ncbi Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy
    Genichi Nishimura
    Department of Surgery II, School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
    Oncol Rep 9:479-82. 2002
    b>Thymidine phosphorylase (TP) converts 5'-deoxy-5-fluorouridine (5'-DFUR, doxifluridine), an intermediate metabolite of capecitabine, to 5-fluorouracil (5-FU)...
  45. ncbi p53, bcl-2 and thymidine phosphorylase as predictive markers of chemotherapy in patients with advanced and recurrent gastric cancer
    S Kikuyama
    Department of Surgery, Tochigi National Hospital, Japan
    Anticancer Res 21:2149-53. 2001
    To study the relationship between expression of p53, bcl-2, thymidine phosphorylase and Ki-67 and the response to chemotherapy and survival in patients with recurrent and advanced gastric cancer.
  46. ncbi Thymidine phosphorylase (platelet-derived endothelial cell growth factor) as a target for capecitabine: from biology to the bedside
    Girolamo Ranieri
    National Cancer Institute, Interventional Radiology Unit, Bari, Italy
    Recent Pat Anticancer Drug Discov 1:171-83. 2006
    b>Thymidine phosphorylase (TP), also known as platelet derived endothelial cell growth factor (PD-ECGF), is an enzyme involved in thymidine synthesis and degradation and exerts an angiogenic activity, whereas N4 pentyloxy-carbonyl- 5'-..
  47. ncbi Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose
    Ryuji Ikeda
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 291:806-12. 2002
    An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia...
  48. ncbi Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency
    Ramon Marti
    Department of Neurology, Columbia University College of Physicians and Surgeons, P and S 4 443, 630 West 168th Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 303:14-8. 2003
    Mutations in the nuclear gene encoding thymidine phosphorylase (TP) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive disease with mitochondrial dysfunction and mitochondrial DNA abnormalities...
  49. ncbi Significance of monocyte chemotactic protein-1 and thymidine phosphorylase in angiogenesis of human cardiac myxoma
    Tianshu Zhang
    Second Department of Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Circ J 67:54-60. 2003
    ..of this study was to investigate whether the expression of monocyte chemotactic protein-1 (MCP-1) and of thymidine phosphorylase (TP) correlates with the angiogenesis and clinicopathologic features in cardiac myxoma...
  50. ncbi Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survival
    Muhammad Wasif Saif
    Yale University School of Medicine, Yale Cancer Center, Section of Medical Oncology, 333 Cedar Street FMP 116, New Haven, CT 06520, USA
    Expert Opin Drug Saf 8:507-14. 2009
    Dihydropyrimidine dehydrogenase (DPD) is the first rate limiting enzyme that catabolizes 5-fluorouracil. Thymidine phosphorylase (TP) catalyzes the last step that converts capecitabine into 5-fluorouracil...
  51. ncbi IFN gamma-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in bladder cancer cells
    Gang Li
    Department of Urology and Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8519, Japan
    Anticancer Res 22:2607-12. 2002
    ..PD-ECGF/TP is an essential enzyme in converting 5'DFUR and 5FU to their active metabolites and can be up-regulated by some cytokines...
  52. ncbi Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer
    Dong Hua
    Oncology Institute of Wuxi, The Fourth Affiliated Hospital of Suzhou University, 200 Huihe Road, Wuxi 214062, Jiangsu Province, China
    World J Gastroenterol 13:5030-4. 2007
    To investigate the prognostic role of thymidylate synthase (TS) and thymidine phosphorylase (TP) mRNA levels in T3 or T4 gastric cancer treated with 5-fluorouracil-based adjuvant chemotherapy.
  53. ncbi Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda
    Maria Ait-Tihyaty
    Cancer Drug Research Laboratory, Department of Medicine, McGill University Health Center Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada
    Breast Cancer Res Treat 133:217-26. 2012
    ..The conversion of 5'-DFUR to the cytotoxic 5-FU, occurs primarily in the tumour and is catalyzed by thymidine phosphorylase (TP)...
  54. ncbi Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells
    Maysoon M Abbas
    Department of Obstetrics and Gynaecology, Christchurch School of Medicine and Health Sciences and the New Zealand Centre for Reproductive Medicine, New Zealand
    Fertil Steril 82:1048-53. 2004
    To study the regulation of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), two angiogenic factors, in cultured endometrial stromal cells...
  55. ncbi Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity
    Kengo Tsuneyoshi
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Lett 244:239-46. 2006
    b>Thymidine phosphorylase (TP) regulates intracellular thymidine metabolism and can enhance the anti-tumor effectiveness of 5'-deoxy-5-fluorouridine (5'-DFUR) by conversion of the pro-drug 5'-DFUR to 5-fluorouracil (5-FU) in tumor tissues...
  56. ncbi Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for oral squamous cell carcinoma
    Chi Sheng Wu
    Molecular Medicine Research Center, Chang Gung University, Tao Yuan, Taiwan
    Oral Oncol 48:516-22. 2012
    ..In vitro experiments suggest that OSCC tumors with high levels of TP are more sensitive to 5'-DFUR treatment. Thus, cytoplasmic hnRNP K and TP may be potential prognostic and therapeutic markers for OSCC...
  57. ncbi Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase
    Hideki Yamashita
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 NIshi cho, Yonago, Tottori 683 8503, Japan
    Int J Mol Med 14:565-70. 2004
    ..tumors (BFHTs), comparing the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), as well as intratumoral microvessel density (IMVD). COX-2 expression was noted in 22 (62...
  58. ncbi Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma
    Takahiro Ezaki
    Department of Disaster and Emergency Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Int J Clin Oncol 10:171-6. 2005
    Measurement of thymidine phosphorylase (TP) activity in normal liver tissue adjacent to hepatocellular carcinoma (HCC) may predict multicentric recurrence a long time after an operation...
  59. ncbi Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy
    Yuen Li Chung
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Clin Cancer Res 10:3863-70. 2004
    Previous studies have shown that tumor response to capecitabine strongly correlates with tumor thymidine phosphorylase (TP). The aims of our study were to (a)...
  60. ncbi Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
    Wasaburo Koizumi
    Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
    Anticancer Drugs 19:819-24. 2008
    The objective of this study was to investigate the relationship between the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and the response to capecitabine in patients with advanced/recurrent gastric ..
  61. ncbi An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA
    Tomohiro Emura
    Cancer Research Laboratories, Hanno Research Center, Taiho Pharmaceutical Co, Ltd, Hanno City, Saitama 357 8527, Japan
    Int J Mol Med 13:249-55. 2004
    TAS-102 is a combination drug consisting of alpha,alpha,alpha-trifluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI)...
  62. ncbi Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine
    Tao Ma
    Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    World J Gastroenterol 10:172-6. 2004
    ..the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to ..
  63. ncbi Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1
    Wei Li
    Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Arterioscler Thromb Vasc Biol 25:1370-5. 2005
    b>Thymidine phosphorylase (TP) reportedly promotes endothelial cell migration and induces heme oxygenase (HO)-1 expression. However, its effect on vascular smooth muscle cells (VSMCs) is poorly understood...
  64. pmc The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes
    Kenji Ikuta
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, MuzuhoMizuho ku, Nagoya, 467 8601, Japan
    Arthritis Res Ther 14:R87. 2012
    Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients...
  65. ncbi Localization of thymidine phosphorylase expression in colorectal carcinoma tissues by in situ RT-PCR assay
    Koshi Mimori
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Oncology 62:327-32. 2002
    Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined...
  66. ncbi Expression of thymidine phosphorylase and VEGF in esophageal squamous cell carcinoma
    Takuma Nomiya
    Department of Radiology, Tohoku University Hospital, 1 1, Seiryo machi, Sendai 980 8574, Japan
    Oncol Rep 15:1497-501. 2006
    ..717 for TP/VEGF[+/- or -/+] group, p=0.005). In conclusion, VEGF and TP expression seems to have a relationship with tumor angiogenesis, and co-expression of TP and VEGF seemed to be one of the unfavorable prognostic factors...
  67. ncbi Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer
    Sotaro Sadahiro
    Department of Surgery, Tokai University School of Medicine, Kanagawa 259 1193, Japan
    Cancer Chemother Pharmacol 70:285-91. 2012
    ....
  68. ncbi Importance of thymidine phosphorylase expression at the invasive front of T3 rectal cancer as a prognostic factor
    Kazuhisa Yoshimoto
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Dig Surg 23:331-5. 2006
    Vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) are angiogenic factors...
  69. ncbi Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma
    Masamichi Yasuno
    Department of Surgical Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyou ku, Tokyo 113 8519, Japan
    Oncol Rep 13:405-12. 2005
    b>Thymidine phosphorylase (TP) is a unique enzyme involved not only in angiogenesis, but in 5-fluorouracil (5-FU) metabolism as well. TP is produced by both tumor and stromal cells...
  70. ncbi Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase
    Yukari Harino
    Department of Surgery, Institute of Health Biosciences, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Clin Oncol 13:452-7. 2008
    Angiogenesis plays an important role in tumor growth and metastasis. Thymidine phosphorylase (TP), as well as vascular endothelial growth factor (VEGF), is known to be an angiogenic factor...
  71. ncbi Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer
    Peter P Grimminger
    Department of General, Visceral and Tumor Surgery, University of Cologne, Germany
    Clin Lung Cancer 11:328-34. 2010
    Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are key enzymes in the 5-fluorouracil (5-FU) pathway...
  72. ncbi [Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells]
    Ji min Zhang
    Department of Gastrointestinal Surgery, The Second Hospital, Guangzhou Medicine School, Guangzhou 510260, China
    Zhonghua Yi Xue Za Zhi 84:718-24. 2004
    To detect the thymidine phosphorylase (dThdPase) expression in colorectal carcinoma tissue, and clarify whether dThdPase expressed in macrophage-like cell lines, and monocytes from human peripheral blood can modulate the anticancer ..
  73. ncbi Expression of thymidine phosphorylase by macrophages in colorectal cancer tissues
    Ji min Zhang
    Department of Gastrointestinal Surgery, the Second Hospital of Guangzhou Medical School, Guangzhou 510260, Guangdong Province, China
    World J Gastroenterol 10:545-9. 2004
    To detect the thymidine phosphorylase (dThdPase) expression in human colorectal cancer tissues and cells.
  74. ncbi Localization of thymidine phosphorylase in advanced gastric and colorectal cancer
    Michiya Kobayashi
    Department of Surgery, Kochi Medical School, Oko cho, Kohasu, Nankoku, 783 8505 Japan
    J Mol Histol 35:69-74. 2004
    b>Thymidine phosphorylase (TP) is known to be more concentrated in human cancer tissues than in adjacent normal tissue based on findings using enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry...
  75. ncbi Thymidine phosphorylase expressed in macrophages enhances antitumor effect of 5'-deoxy-5-fluorouridine on human colorectal carcinoma cells
    Jimin Zhang
    Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
    Anticancer Res 23:323-9. 2003
    b>Thymidine phosphorylase (dThdPase) is a key enzyme in the activation of the pro-drugs of 5-fluorouracil (5-FU), 5-deoxy-5-fluorouridine (5'-DFUR) and capecitabine...
  76. ncbi Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase
    Philip Reigan
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Bioorg Med Chem Lett 14:5247-50. 2004
    A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity...
  77. ncbi Late-onset MNGIE due to partial loss of thymidine phosphorylase activity
    Ramon Marti
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann Neurol 58:649-52. 2005
    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the gene encoding thymidine phosphorylase (TP)...
  78. ncbi The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes
    Takuma Kusabe
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 25:625-30. 2005
    ..These findings indicate that AuTG and DEX have anti-rheumatic activity, which is mediated via the suppression of GLS production. Neither methotrexate (MTX) nor sulfasalazine (SSZ) had a significant influence on GLS levels in our study...
  79. doi Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE
    N F Moran
    Neurology, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, CT1 3NG, UK
    Neurology 71:686-8. 2008
  80. ncbi The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist
    Sandra Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Mol Cancer Ther 11:817-29. 2012
    5'-O-Tritylinosine (KIN59) is an allosteric inhibitor of the angiogenic enzyme thymidine phosphorylase. Previous observations showed the capacity of KIN59 to abrogate thymidine phosphorylase-induced as well as developmental angiogenesis ..
  81. ncbi Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers
    Laura Libernini
    Division of Pediatric Neurology, Department of Pediatrics, Child Neurology and Psychiatry, La Sapienza University of Rome, Rome, Italy
    Neuropediatrics 43:201-8. 2012
    ..recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP)...
  82. ncbi Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages
    H Goto
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 61:469-73. 2001
    b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to platelet-derived endothelial cell growth factor...
  83. ncbi The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism
    Harsh V Jain
    Department of Chemistry, University at Buffalo, Buffalo, NY 14260, United States
    Bioorg Med Chem Lett 20:1648-51. 2010
    The design and synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU), a potent inhibitor of thymidine phosphorylase (TP) with K(i)-values of 11nM (ecTP) and 17nM (hTP), are described...
  84. pmc Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP)
    John R Grierson
    Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington, USA
    Nucleosides Nucleotides Nucleic Acids 29:49-54. 2010
    ..5-fluoro analog of TPI (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]uracil), a potent inhibitor of human thymidine phosphorylase (TP), has an IC(50) in a range that might allow to use it labeled for imaging of TP expression in vivo...
  85. ncbi Angiogenic factor
    T Furukawa
    Nature 356:668. 1992
  86. ncbi Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer
    Tomohiko Miyatani
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
    Cancer Lett 318:199-205. 2012
    ..However, there are few to be available in the clinical setting. Thymidine phosphorylase inhibitor (TPI) regulates the phosphorolysis of thymidine to thymine and 2-deoxy-d-ribose-1-phosphate ..
  87. ncbi Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor
    K Asai
    Department of Bioregulation Research, Nagoya City University Medical School, Japan
    J Biol Chem 267:20311-6. 1992
    ..These data indicate that gliostatin/PD-ECGF may play important roles on development and regeneration of the central nervous system and may also involve the induction of angiogenesis for the formation of blood brain barrier...
  88. ncbi The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma
    Shin ichi Aishima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Surg Pathol 10:47-56. 2002
    b>Thymidine phosphorylase (TP), an important regulator of angiogenesis, is correlated with progression, metastasis, and prognosis in various types of tumor...
  89. ncbi A case report of papilla Vater carcinoma showing positive expression of thymidine phosphorylase
    Shinji Osada
    Second Department of Surgery, Gifu University School of Medicine, Gifu City, Japan
    Hepatogastroenterology 51:375-7. 2004
    ..The immunohistochemical stain showed the strong expression of thymidine phosphorylase in the tumor tissue and also in the normal biliary tract, despite positive p53 cells being undetected in ..
  90. ncbi The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine
    Tomohiro Nishina
    Department of Medical Oncology, National Shikoku Cancer Center, 13 Horinouchi, Matsuyama, Ehime 790 0007, Japan
    Eur J Cancer 40:1566-71. 2004
    The aim of this work was to determine whether intratumour contents of thymidine phosphorylase (TP), which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil, and dihydropyrimidine dehydrogenase (DPD), which degrades 5-..
  91. ncbi Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue
    M Zimovjanova
    Department of Oncology, General Teaching Hospital, 12880 Prague, Czech Republic
    Neoplasma 52:208-10. 2005
    Thymidylate synthase [TS], thymidine phosphorylase [TP] and dihydropyrimidine dehydrogenase [DPD] play the essential role in the activation and catabolism of the fluoropyrimidines used in cancer therapy...
  92. ncbi Pd-ECGF positivity correlates with better survival, while iNOS has no predictive value for cervical carcinomas treated with radiotherapy
    Kuniyuki Oka
    Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 57:217-21. 2003
    Platelet-derived endothelial cell growth factor (PD-ECGF), which has angiogenic activity, is identical to thymidine phosphorylase. Tumor vascularization is considered to be an important prognostic factor...
  93. ncbi Neoangiogenesis in patients with gastric carcinoma in relation to the expression of vascular endothelial growth factor and thymidine phosphorylase
    Shunichi Tsujitani
    Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
    Anticancer Res 24:1853-9. 2004
    ..the prognostic significance of microvessel density and the relationship between the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), and angiogenesis in patients with gastric carcinoma.
  94. pmc Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors
    I V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Br J Cancer 104:1185-92. 2011
    b>Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis...
  95. pmc Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
    R D Leek
    Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
    Br J Cancer 77:2246-51. 1998
    ..The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to promote tumour angiogenesis...
  96. ncbi FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes
    Takaya Yamagami
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 31:903-9. 2011
    Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities. The purpose of this study was to determine the inhibitory effects of FK506 (tacrolimus) on GLS production in rheumatoid arthritis (RA)...
  97. ncbi Gliostatin/thymidine phosphorylase-regulated vascular endothelial growth-factor production in human fibroblast-like synoviocytes
    Tomohiro Tanikawa
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho chou, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 27:553-9. 2007
    Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities...
  98. ncbi Late-onset MNGIE without peripheral neuropathy due to incomplete loss of thymidine phosphorylase activity
    Roberto Massa
    Department of Neurosciences, University of Rome Tor Vergata and IRCCS Fondazione S Lucia, Via Montpellier 1, I 00135 Rome, Italy
    Neuromuscul Disord 19:837-40. 2009
    ..Mutations in the TYMP/ECGF1 gene cause a loss of thymidine phosphorylase catalytic activity, disrupting the homeostasis of intramitochondrial nucleotide pool...
  99. ncbi Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling
    M J Currie
    Anatomical Pathology, Canterbury Health, Christchurch Hospital, Christchurch, New Zealand
    Clin Cancer Res 7:918-27. 2001
    ..016) and a significant inverse correlation between Ang-1 and thymidine phosphorylase expression (P = 0.01)...
  100. pmc Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis
    D P Stevenson
    Diagnostics Research Unit, Department of Obstetrics and Gynecology, King s College School of Medicine and Dentistry, London, United Kingdom
    Am J Pathol 152:1641-6. 1998
    Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is associated with angiogenesis and the progression of human breast and ovarian cancers...
  101. ncbi Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver
    T Komatsu
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Clin Cancer Res 7:675-81. 2001
    ..Because the conversion of tegafur into 5-FU has also been reported to be catalyzed by cytosolic thymidine phosphorylase (dThdPase), the involvement of human liver microsomes and cytosol and individual differences in 5-FU ..

Research Grants31

  1. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2013
    ..MNGIE) is a fatal autosomal recessive disease caused by mutations in the TYMP gene encoding thymidine phosphorylase (TP)...
  2. Interactions of the angiopoietin and PD-ECGF pathways in tumor angiogenesis
    Edward L Schwartz; Fiscal Year: 2013
    ..include a novel, highly specific, orally available small molecule inhibito of the angiogenic factor thymidine phosphorylase (TP) which we have synthesized, and two highly specific peptibodies which neutralize the angiogenic ..
  3. Mechanisms of thymide phosphorylase angiogenesis
    Edward L Schwartz; Fiscal Year: 2010
    ..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
  4. 3-D STRUCTURES OF URIDINE & THYMIDINE PHOSPHORYLASES
    Steven Ealick; Fiscal Year: 1991
    The objective is to determine the three-dimensional structures of uridine phosphorylase and thymidine phosphorylase. The pyrimidine phosphorylases may be responsible for the degradation of certain nucleoside analogs of potential ..
  5. TUMOR MARKERS TO PREDICT TREATMENT RESPONSE
    Lynn Dressler; Fiscal Year: 2005
    ..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
  6. ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPY
    Giuseppe Pizzorno; Fiscal Year: 2004
    ..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
  7. ANTIANGIOGENESIS BY THYMIDINE PHOSPHORYLASE INHIBITORS
    George Wright; Fiscal Year: 1999
    ..One angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF), is identical with thymidine phosphorylase (TP), an enzyme of thymidine metabolism and homeostasis...
  8. CELLULAR INTERACTIONS OF 5 FLUOROURACIL AND INTERFERON
    Edward Schwartz; Fiscal Year: 2000
    ..activity was identified: the induction of expression by IFN, both in vitro and in vivo, of the enzyme thymidine phosphorylase (TP)...
  9. MOLECULAR PROGNOSTIC INDICATORS IN COLORECTAL CANCER
    Leonard Saltz; Fiscal Year: 2000
    ..Further data suggest that low expression of both thymidine phosphorylase and dihydropyrimidine dehydrogenase are consistent with responsiveness to FU/LV, while high expression of ..
  10. CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASE
    Salvatore DiMauro; Fiscal Year: 2007
    ..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
  11. dUTPase As A Prognostic Marker in Colon Cancer
    Robert Ladner; Fiscal Year: 2003
    ..expression with other known prognostic markers of colorectal cancer including, thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and p53...
  12. Studies of the Pathogenic Mechanism of HIV
    Miles Cloyd; Fiscal Year: 2003
    ..e., are activated and are undergoing "activation-induced cell death") or are thymidine phosphorylase+ (i.e...
  13. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
  14. Biomodulation of capecitabine by docetaxel in non-small*
    MIGUEL VILLALONA; Fiscal Year: 2005
    ..This synergy is believed due to upregulation of the enzyme thymidine phosphorylase (TP), which is responsible for the preferential tumor activation of capecitabine...
  15. PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES IN CHEMOTHERAPY
    SHIH CHU; Fiscal Year: 1992
    ..2. Biological testing of these new agents as inhibitors of uridine phosphorylase and, where indicated, thymidine phosphorylase, as transport inhibitors, anti-tumor agents and potentiators both in vitro and in vivo, and as tools for ..
  16. Phase l study of 131 I-HuA33 with oral capecitabine in*
    Andrew Scott; Fiscal Year: 2006
    ..The final conversion to 5-FU is by thymidine phosphorylase, which is much more active in colorectal tumor tissue compared to normal tissues...
  17. MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCER
    Peter Danenberg; Fiscal Year: 2001
    ..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
  18. ENZYME MARKER FOR HEMATOPOIETIC CELLS
    Sohaib Khan; Fiscal Year: 1980
    b>Thymidine phosphorylase activity will be measured in leukemic cell lines of T- and B-cell origin. The enzyme activity will also be followed in human leukemias...
  19. Pathogenesis of a Novel Limb-Girdle Muscular Dystrophy
    Michio Hirano; Fiscal Year: 2003
    ..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
  20. Effect of ethanol on retinoid metabolism and signaling in zebrafish embryos
    WILLIAM BOSRON; Fiscal Year: 2007
    ..We will assess the feasibility of performing targeted proteomics studies with tissues from other populations that express different SNPs in alcohol metabolizing enzymes. [unreadable] [unreadable] [unreadable]..
  21. The Role of Mitochondrial DNA Alterations in Cancer
    Lee Jun Wong; Fiscal Year: 2008
    ..Results from this research project will help us understand the functional role of mitochondrial DNA alterations in cancer and identify potential novel targets for more effective therapeutic development. ..
  22. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern Schramm; Fiscal Year: 2007
    ..unreadable]..
  23. Toxoplasma Adenosine Kinase & Chemotherapy
    MAHMOUD EL KOUNI; Fiscal Year: 2007
    ..Determine the mechanism of selective toxicity of active compounds. These studies will utilize the complementary strengths of the investigators in a collaborative, integrated effort to achieve these goals. [unreadable] [unreadable]..
  24. Retinoid Metabolism in Hepatitic Stellate Cells
    WILLIAM BOSRON; Fiscal Year: 2005
    ..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
  25. CALGB STUDIES OF BREAST CANCER IN THE ELDERLY
    Richard Schilsky; Fiscal Year: 2004
    ..This well integrated project provides a multidisciplinary approach that will address many issues relevant to the treatment of elderly women with breast cancer. ..
  26. ERBB 2 ERBB 3 HETERODIMERIC RECEPTOR OF CARCINOMAS
    Yosef Yarden; Fiscal Year: 2004
    ..This model will be examined by using mutant receptors, and the recycling machinery characterized in details. The suspected cancer-inhibitory activity of drugs interfering with ErbB routing will be tested in vivo. ..
  27. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS-INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 2003
    ..The goal of this work is to extend transition state inhibitor design to the complex reactions catalyzed by bacterial ADP-ribosylating toxins. ..
  28. CPT11 activation by carboxylesterases in colon cancer
    WILLIAM BOSRON; Fiscal Year: 2003
    ..If there is a positive correlation, a future multi-institutional study will be proposed. ..
  29. Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy
    MAHMOUD EL KOUNI; Fiscal Year: 2002
    ..This will increase the use of FUra and enhance its commercial potential. Two patents have been awarded to protect the technology and were licensed to the Company. ..
  30. ADENOSINE KINASE TARGET FOR CHEMOTHERAPY IN TGONDII
    MAHMOUD EL KOUNI; Fiscal Year: 2001
    ..gondii; (3) evaluate active compounds as potential antitoxoplasmosis agents in vitro and in vivo. ..