glucosyltransferases

Summary

Summary: Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.

Top Publications

  1. pmc Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics
    David M Brown
    Faculty of Life Science, University of Manchester, Manchester M13 9PT United Kingdom
    Plant Cell 17:2281-95. 2005
  2. ncbi Cellulose synthesis in higher plants
    Chris Somerville
    Department of Plant Biology, Carnegie Institution, and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:53-78. 2006
  3. pmc Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:8633-8. 2005
  4. ncbi Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana
    Brigitte Poppenberger
    Center of Applied Genetics, BOKU University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Biol Chem 278:47905-14. 2003
  5. ncbi Cellulose synthases and synthesis in Arabidopsis
    Anne Endler
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    Mol Plant 4:199-211. 2011
  6. ncbi Visualization of cellulose synthase demonstrates functional association with microtubules
    Alexander R Paredez
    Department of Biological Sciences, Stanford University, 260 Panama Street, Stanford, CA 94305, USA
    Science 312:1491-5. 2006
  7. pmc Interactions among three distinct CesA proteins essential for cellulose synthesis
    Neil G Taylor
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 100:1450-5. 2003
  8. pmc Three distinct rice cellulose synthase catalytic subunit genes required for cellulose synthesis in the secondary wall
    Katsuyuki Tanaka
    Institute of the Society for Techno Innovation of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki 305 0854, Japan
    Plant Physiol 133:73-83. 2003
  9. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
  10. ncbi The (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation
    Juan Carlos G Cortés
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    Mol Microbiol 65:201-17. 2007

Research Grants

  1. DISPERSION OF STREPTOCOCCUS MUTANS BIOFILMS BY A NOVEL SMALL MOLECULE
    SANDRA S GARCIA; Fiscal Year: 2013
  2. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2012
  3. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
  4. Regulation of gtf Gene Expression in S mutans
    Steven Goodman; Fiscal Year: 2005
  5. GENETICS OF ORAL MICROFLORA
    FRANCIS MACRINA; Fiscal Year: 2000
  6. GLYCOSYLTRANSFERASES FROM ORAL BACTERIA
    KUMARI DEVULAPALLE; Fiscal Year: 1999
  7. Approach to control caries through apple-derived vaccine
    Hilary Koprowski; Fiscal Year: 2006
  8. POLYPHENOL OXIDASES AS ANTIADHESINS
    RONALD DOYLE; Fiscal Year: 1999
  9. CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITY
    Daniel Smith; Fiscal Year: 2007
  10. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004

Detail Information

Publications314 found, 100 shown here

  1. pmc Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics
    David M Brown
    Faculty of Life Science, University of Manchester, Manchester M13 9PT United Kingdom
    Plant Cell 17:2281-95. 2005
    ..These genes are likely to define entirely novel processes in secondary cell wall formation and illustrate the success of combining expression data with reverse genetics to address gene function...
  2. ncbi Cellulose synthesis in higher plants
    Chris Somerville
    Department of Plant Biology, Carnegie Institution, and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 22:53-78. 2006
    ..Genetic studies in Arabidopsis have identified a number of genes that contribute to the overall process of cellulose synthesis, but the role of these proteins is not yet known...
  3. pmc Identification of genes required for cellulose synthesis by regression analysis of public microarray data sets
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:8633-8. 2005
    ..Thus, the general approach developed here is useful for identification of elements of multicomponent processes...
  4. ncbi Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana
    Brigitte Poppenberger
    Center of Applied Genetics, BOKU University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Biol Chem 278:47905-14. 2003
    ..Constitutive overexpression in Arabidopsis leads to enhanced tolerance against deoxynivalenol...
  5. ncbi Cellulose synthases and synthesis in Arabidopsis
    Anne Endler
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    Mol Plant 4:199-211. 2011
    ..These advances may become good platforms for expanding our knowledge about cellulose synthesis in the near future. In addition, our current understanding of cellulose chain polymerization in the context of the CesA complex is discussed...
  6. ncbi Visualization of cellulose synthase demonstrates functional association with microtubules
    Alexander R Paredez
    Department of Biological Sciences, Stanford University, 260 Panama Street, Stanford, CA 94305, USA
    Science 312:1491-5. 2006
    ..Inhibition of microtubule polymerization changed the fine-scale distribution and pattern of moving CESA complexes in the membrane, indicating a relatively direct mechanism for guidance of cellulose deposition by the cytoskeleton...
  7. pmc Interactions among three distinct CesA proteins essential for cellulose synthesis
    Neil G Taylor
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 100:1450-5. 2003
    ..Consequently, these data suggest that IRX5, IRX3, and IRX1 are all essential components of the cellulose synthesizing complex and the presence of all three subunits is required for the correct assembly of this complex...
  8. pmc Three distinct rice cellulose synthase catalytic subunit genes required for cellulose synthesis in the secondary wall
    Katsuyuki Tanaka
    Institute of the Society for Techno Innovation of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki 305 0854, Japan
    Plant Physiol 133:73-83. 2003
    ..Based on these observations, the structure of a cellulose-synthesizing complex involved in the synthesis of the secondary cell wall is discussed...
  9. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
    ..It is also recognized that glucosyltransferases from S. mutans (Gtfs) play critical roles in the development of virulent dental plaque...
  10. ncbi The (1,3)beta-D-glucan synthase subunit Bgs1p is responsible for the fission yeast primary septum formation
    Juan Carlos G Cortés
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    Mol Microbiol 65:201-17. 2007
    ..We also show that in the absence of Bgs1p abnormal septa are formed, but the cells cannot separate and eventually die...
  11. ncbi PilZ domain is part of the bacterial c-di-GMP binding protein
    Dorit Amikam
    Department of Biotechnology and Environmental Sciences, Tel Hai Academic College Tel Hai, Israel
    Bioinformatics 22:3-6. 2006
    ....
  12. pmc Pausing of Golgi bodies on microtubules regulates secretion of cellulose synthase complexes in Arabidopsis
    Elizabeth Faris Crowell
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Cell 21:1141-54. 2009
    ....
  13. ncbi Molecular analysis of cellulose biosynthesis in Arabidopsis
    T Arioli
    Cooperative Research Centre for Plant Science, Australian National University, Post Office Box 475, Canberra, ACT 2601, Australia
    Science 279:717-20. 1998
    ..Microfibril crystallization may require proper assembly of the RSW1 gene product into synthase complexes whereas glucan biosynthesis per se does not...
  14. pmc Genetic evidence for three unique components in primary cell-wall cellulose synthase complexes in Arabidopsis
    Staffan Persson
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:15566-71. 2007
    ..We also show that the CESA6-related CESAs are partially functionally redundant...
  15. pmc POM-POM2/cellulose synthase interacting1 is essential for the functional association of cellulose synthase and microtubules in Arabidopsis
    Martin Bringmann
    Max Planck Institute for Molecular Plant Physiology, 14476 Potsdam, Germany
    Plant Cell 24:163-77. 2012
    ..We propose that POM2/CSI1 provides a scaffold between the CESAs and cortical microtubules that guide cellulose synthesis...
  16. pmc Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes
    Shundai Li
    Center for LignoCellulose Structure and Formation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 109:185-90. 2012
    ..CSI1 directly binds to microtubules as demonstrated by in vitro microtubule-binding assay...
  17. pmc Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
    Aleksandra Szwagierczak
    Department of Biology, Center for Integrated Protein Science Munich, Ludwig Maximilians University Munich, 82152 Planegg Martinsried, Germany
    Nucleic Acids Res 38:e181. 2010
    ..We determined hmC levels in various adult tissues and differentiating embryonic stem cells and show a correlation with differential expression of tet genes...
  18. ncbi Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis
    Zhizhong Chen
    State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
    Plant J 43:273-83. 2005
    ..Our results suggest that cellulose synthesis is important for drought and osmotic stress responses including drought induction of gene expression...
  19. pmc Inhibition of SNF1-related protein kinase1 activity and regulation of metabolic pathways by trehalose-6-phosphate
    Yuhua Zhang
    Plant Science, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, United Kingdom
    Plant Physiol 149:1860-71. 2009
    ..These experiments provide strong evidence that T6P inhibits SnRK1 to activate biosynthetic processes in growing tissues...
  20. pmc Suppression of sucrose synthase gene expression represses cotton fiber cell initiation, elongation, and seed development
    Yong Ling Ruan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Canberra, ACT 2601, Australia
    Plant Cell 15:952-64. 2003
    ..Additional suppression in the endosperm and embryo inhibits their own development, which blocks the formation of adjacent seed coat transfer cells and arrests seed development entirely...
  21. pmc Expression profiling and integrative analysis of the CESA/CSL superfamily in rice
    Lingqiang Wang
    National Key Laboratory of Crop Genetic Improvement, Biomass and Bioenergy Research Centre, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China
    BMC Plant Biol 10:282. 2010
    ..Although the rice (Oryza sativa L.) genome has been sequenced for a few years, the global expression profiling patterns and functions of the OsCESA/CSL superfamily remain largely unknown...
  22. pmc Identification of a cellulose synthase-associated protein required for cellulose biosynthesis
    Ying Gu
    Energy Biosciences Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:12866-71. 2010
    ..CSI1 is associated with CESA complexes, and csi1 mutants affect the distribution and movement of CESA complexes in the plasma membrane...
  23. pmc A vital role for glycosphingolipid synthesis during development and differentiation
    T Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:9142-7. 1999
    ....
  24. pmc Insights on the evolution of trehalose biosynthesis
    Nelson Avonce
    Centro de Investigación en Biotecnología UAEM, Av Universidad 1001, Col Chamilpa, Cuernavaca 62210, Mexico
    BMC Evol Biol 6:109. 2006
    ..However, in recent years it has been shown that although higher plants do not accumulate trehalose at significant levels they have actively transcribed genes encoding the corresponding biosynthetic enzymes...
  25. ncbi Sucrose synthase is an integral component of the cellulose synthesis machinery
    Satoshi Fujii
    Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka, 560 0043 Japan f
    Plant Cell Physiol 51:294-301. 2010
    ..Our results suggest that the plasma membrane-associated rosette anchors the catalytic unit of cellulose synthesis to form the functional cellulose synthesis machinery...
  26. ncbi Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA
    Robert P Gibson
    Department of Chemistry, The University of York, York YO10 5YW, Heslington, United Kingdom
    Chem Biol 9:1337-46. 2002
    ..The overall structure and the intimate details of the catalytic machinery reveal a striking similarity to glycogen phosphorylase, indicating a strong evolutionary link and suggesting a common catalytic mechanism...
  27. pmc Resistance to echinocandin-class antifungal drugs
    David S Perlin
    Public Health Research Institute, New Jersey Medical School UMDNJ, Newark, NJ, USA
    Drug Resist Updat 10:121-30. 2007
    ..and can account for intrinsic reduced susceptibility of certain species. Fks1 mutations confer resistance in both yeasts and moulds suggesting that this mechanism is pervasive in the fungal kingdom...
  28. pmc Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence
    Amy J Reese
    Department of Biological Sciences, Cedar Crest College, Allentown, PA 18104 6196, USA
    Mol Microbiol 63:1385-98. 2007
    ..The mutants were unable to grow ina mouse model of infection, but caused death in nematodes. These studies integrate morphological and biochemical investigations of the role of alpha glucan in the cryptococcal cell wall...
  29. pmc Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis
    Ran Zhang
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    J Biol Chem 286:35601-9. 2011
    ....
  30. ncbi Ceramide glycosylation potentiates cellular multidrug resistance
    Y Y Liu
    John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA
    FASEB J 15:719-30. 2001
    ..This study reveals that GCS is a novel mechanism of multidrug resistance and positions GCS antisense as an innovative force to overcome multidrug resistance in cancer chemotherapy...
  31. pmc Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway
    Rainer Kalscheuer
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Chem Biol 6:376-84. 2010
    ..tuberculosis...
  32. pmc Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses
    Laurent D Noël
    Institut de Biologie Environementale et Biotechnologie, Unite Mixte de Recherche 6191, Centre National de la Recherche Scientifique, Universite de la Mediterranee Aix Marseille II, Saint Paul lez Durance cedex, France
    Plant Cell 19:4061-76. 2007
    ..We conclude that an HSC70-SGT1 chaperone complex is important for multiple plant environmental responses and that the evolutionarily conserved SGS domain of SGT1 is a key determinant of the HSC70-SGT1 association...
  33. ncbi Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential for Arabidopsis embryo maturation
    Peter J Eastmond
    Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    Plant J 29:225-35. 2002
    ..Our data establish for the first time that an enzyme of trehalose metabolism is essential in plants and is implicated in the regulation of sugar metabolism/embryo development via a different mechanism to that reported in S. cerevisiae...
  34. ncbi Validation of a candidate deoxynivalenol-inactivating UDP-glucosyltransferase from barley by heterologous expression in yeast
    Wolfgang Schweiger
    Department of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Mol Plant Microbe Interact 23:977-86. 2010
    ..We also tested four candidate barley glucosyltransferases, which are highly DON inducible...
  35. pmc Trehalose mediated growth inhibition of Arabidopsis seedlings is due to trehalose-6-phosphate accumulation
    Henriette Schluepmann
    Molecular Plant Physiology, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Plant Physiol 135:879-90. 2004
    ..Interestingly, Suc addition represses 15 of these genes, one of which is AtKIN11, encoding a Sucrose Non Fermenting 1 (SNF1)-related kinase known to play a role in Suc utilization...
  36. ncbi Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton
    M Arellano
    Instituto de Microbiologia Bioquimica, CSIC Universidad de Salamanca, Spain
    J Cell Sci 110:2547-55. 1997
    ..We conclude that rho1p localisation is restricted to growth areas and regulated during the cell cycle and that rho1p is involved in cell wall growth and actin cytoskeleton organisation in S. pombe...
  37. ncbi Phylogenetic and expression analysis of sucrose phosphate synthase isozymes in plants
    Linda L Lutfiyya
    Monsanto Company, 800 North Lindbergh Boulevard, St Louis, MO 63167, USA
    J Plant Physiol 164:923-33. 2007
    ..Our data suggests that higher plant SPS isozymes differ with respect to their patterns of expression and regulation and that our proposed phylogenetic classification reflects specific functional categories for higher plant SPS isozymes...
  38. pmc Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila
    Yury Belyi
    Gamaleya Research Institute, Moscow 123098, Russia
    J Bacteriol 190:3026-35. 2008
    ..Thus, the data indicate that members of the L. pneumophila glucosyltransferase family are differentially regulated, affect protein synthesis of host cells, and represent potential virulence factors of Legionella...
  39. pmc Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity
    Marta Botër
    Sainsbury Laboratory, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 19:3791-804. 2007
    ..Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1-HSP90 interaction by promoting ternary complex formation...
  40. pmc The UGT73C5 of Arabidopsis thaliana glucosylates brassinosteroids
    Brigitte Poppenberger
    Center for Novel Agricultural Products, Department of Biology, University of York, YO10 5DD, York, United Kingdom
    Proc Natl Acad Sci U S A 102:15253-8. 2005
    ..These data support the hypothesis that 23-O-glucosylation of BL is a function of UGT73C5 in planta, and that glucosylation regulates BR activity...
  41. pmc Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants
    W R Scheible
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94305-4150, USA
    Proc Natl Acad Sci U S A 98:10079-84. 2001
    ..Although the IXR1 gene is expressed in the same cells as the structurally related RSW1 (AtCESA1) cellulose synthase gene, these two CESA genes are not functionally redundant...
  42. pmc Higher plants contain homologs of the bacterial celA genes encoding the catalytic subunit of cellulose synthase
    J R Pear
    Calgene Inc, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 93:12637-42. 1996
    ..Cotton celA1 and celA2 genes are expressed at high levels during active secondary wall cellulose synthesis in developing cotton fibers. Genomic Southern blot analyses in cotton demonstrate that celA forms a small gene family...
  43. ncbi Cellulose biosynthesis in plants: from genes to rosettes
    Monika S Doblin
    University of California, Davis, CA 95616, USA
    Plant Cell Physiol 43:1407-20. 2002
    ..These proteins should prove valuable in identifying additional CelS components...
  44. ncbi Cellulose synthesis: a complex complex
    Marek Mutwil
    Max Planck Institute for Molecular Plant Physiology, Am Muehlenberg 2, Potsdam, Germany
    Curr Opin Plant Biol 11:252-7. 2008
    ..In addition, fluorescently tagged CESA2 subunits may substitute for another subunit, CESA6, which suggests both plasticity and specificity for one of the components of the CESA complex...
  45. pmc Resistance against herbicide isoxaben and cellulose deficiency caused by distinct mutations in same cellulose synthase isoform CESA6
    Thierry Desprez
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Physiol 128:482-90. 2002
    ..Together, these observations are compatible with a model in which CESA6 and CESA3 are active as a protein complex...
  46. ncbi Identification of glucosyltransferase genes involved in sinapate metabolism and lignin synthesis in Arabidopsis
    E K Lim
    Department of Biology, University of York, York YO10 5DD, United Kingdom
    J Biol Chem 276:4344-9. 2001
    ..b>Glucosyltransferases play key roles in the formation of these intermediates, either through the production of the high energy ..
  47. pmc The cellulose synthase superfamily in fully sequenced plants and algae
    Yanbin Yin
    Computational System Biology Lab, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, BioEnergy Science Center, USA
    BMC Plant Biol 9:99. 2009
    ..With 17 plant and algal genomes fully sequenced, we sought to conduct a genome-wide and systematic investigation of this superfamily through in-depth phylogenetic analyses...
  48. pmc Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms
    H Koo
    Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:3024-32. 2010
    ..The exopolysaccharides, which are mostly glucans synthesized by streptococcal glucosyltransferases (Gtfs), provide binding sites that promote accumulation of microorganisms on the tooth surface and further ..
  49. ncbi Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
    Johannes M Aerts
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes 56:1341-9. 2007
    ....
  50. pmc A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1
    Elena Lukina
    Hematology Research Center, Russian Academy of Medical Sciences, Moscow, Russia
    Blood 116:893-9. 2010
    ..Individual pharmacokinetics varied; mean time to maximal observed concentration was 2.3 hours and mean half-life was 6.8 hours. Eliglustat tartrate appears to be a promising oral treatment for GD1...
  51. pmc Sucrose phosphate synthase activity rises in correlation with high-rate cellulose synthesis in three heterotrophic systems
    V M Babb
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant Physiol 127:1234-42. 2001
    ..The significance of these findings in regard to directing metabolic flux toward cellulose will be discussed...
  52. ncbi Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines
    Solène Grazide
    INSERM U563 Centre de Physiopathologie Toulouse Purpan, Institut Claudius Regaud, Toulouse 31052, France
    J Biol Chem 279:18256-61. 2004
    ..In conclusion, this study suggests that sphingomyelin-derived CER in itself is not a second messenger but rather a precursor of both an apoptosis second messenger (GD3) and an apoptosis "protector" (GalCER)...
  53. ncbi Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stress
    Andreas Wolf
    Institut fur Biochemie, Universitat zu Koln, Zülpicher Str 47, 50674 Koln, Germany
    Mol Microbiol 49:1119-34. 2003
    ..Also, evidence is given that both the OtsAB and the TreYZ pathways are involved, but not essential, in supplying trehalose for mycolic acid biosynthesis...
  54. pmc Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA
    Int J Oncol 39:425-31. 2011
    ..Although a small study, these data suggest that GCS may be a prognostic indicator and potential target for the treatment of chemotherapy-refractory breast cancer...
  55. ncbi Expression patterns of genes encoding carbohydrate-metabolizing enzymes and their relationship to grain filling in rice (Oryza sativa L.): comparison of caryopses located at different positions in a panicle
    Tsutomu Ishimaru
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo, Tokyo, 113 8657 Japan
    Plant Cell Physiol 46:620-8. 2005
    ..Based on the comparison of superior and inferior caryopses, the possible mechanism of grain filling in rice is discussed...
  56. pmc Expression of a bifunctional fusion of the Escherichia coli genes for trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in transgenic rice plants increases trehalose accumulation and abiotic stress tolerance without stunting growth
    In Cheol Jang
    Department of Biological Science, Myongji University, Yongin 449 728, Korea
    Plant Physiol 131:516-24. 2003
    ..Thus, our results suggest that trehalose acts as a global protectant against abiotic stress, and that rice is more tolerant to trehalose synthesis than dicots...
  57. ncbi The variable C-terminus of 14-3-3 proteins mediates isoform-specific interaction with sucrose-phosphate synthase in the yeast two-hybrid system
    Frederik Börnke
    Institut fur Pflanzengenetik und Kulturpflanzenforschung, Corrensstrasse 3, Gatersleben 06466, Germany
    J Plant Physiol 162:161-8. 2005
    ..These findings suggest that the large number of 14-3-3 isoforms present in plants reflects functional specificity...
  58. pmc Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply
    Axel Tiessen
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Cell 14:2191-213. 2002
    ..Furthermore, activation of AGPase resulted in a stimulation of starch synthesis and decreased levels of glycolytic intermediates...
  59. ncbi Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation
    Yusuf Baran
    Department of Molecular Biology and Genetics, Izmir Institute of Technology, Faculty of Science, Gulbahce Campus, 35430, Urla, Izmir, Turkey
    J Cancer Res Clin Oncol 137:1535-44. 2011
    ..2 and K562/IMA-1 human CML cells, which exhibit about 2.3- and 19-fold imatinib resistance, respectively...
  60. ncbi Molecular cloning and heterologous expression of novel glucosyltransferases from tobacco cultured cells that have broad substrate specificity and are induced by salicylic acid and auxin
    G Taguchi
    Gene Research Center, Shinshu University, Ueda, Japan
    Eur J Biochem 268:4086-94. 2001
    ..We report here the molecular cloning of glucosyltransferases that can catalyze the glucosylation of many kinds of secondary metabolites including scopoletin...
  61. ncbi Association genetics of chemical wood properties in black poplar (Populus nigra)
    Fernando P Guerra
    Department of Plant Sciences, University of California at Davis, Davis, CA 95616, USA
    New Phytol 197:162-76. 2013
    ....
  62. ncbi An integrative analysis of four CESA isoforms specific for fiber cellulose production between Gossypium hirsutum and Gossypium barbadense
    Ao Li
    National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Planta 237:1585-97. 2013
    ..In addition, we discussed that callose synthesis might be regulated in vivo for massive cellulose production during active secondary cell wall biosynthesis in cotton fibers...
  63. ncbi A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola
    Mathias Blum
    Institute of Botany, University of Basel, Basel, Switzerland
    Fungal Genet Biol 47:499-510. 2010
    ..Our data demonstrate that the identified genes are putative cellulose synthases and that one recessive mutation in PvCesA3 causes inheritable resistance to the CAA fungicide mandipropamid...
  64. ncbi Overexpression of a potato sucrose synthase gene in cotton accelerates leaf expansion, reduces seed abortion, and enhances fiber production
    Shou Min Xu
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    Mol Plant 5:430-41. 2012
    ....
  65. pmc Changes in the oligomerization potential of the division inhibitor UgtP co-ordinate Bacillus subtilis cell size with nutrient availability
    An Chun Chien
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Mol Microbiol 86:594-610. 2012
    ....
  66. ncbi Cloning and characterization of homeologous cellulose synthase catalytic subunit 2 genes from allotetraploid cotton (Gossypium hirsutum L.)
    Hee Jin Kim
    USDA ARS, Southern Regional Research Center, Cotton Fiber Bioscience, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA
    Gene 494:181-9. 2012
    ....
  67. pmc Metabolic and enzymatic changes associated with carbon mobilization, utilization and replenishment triggered in grain amaranth (Amaranthus cruentus) in response to partial defoliation by mechanical injury or insect herbivory
    Paula Andrea Castrillón-Arbeláez
    Unidad de Biotecnología e Ingeniería Genética de Plantas Cinvestav Irapuato, Km 9, 6 del Libramiento Norte Carretera Irapuato León, Apartado Postal 629, C, P, 36821, Irapuato, Gto, Mexico
    BMC Plant Biol 12:163. 2012
    ..A multi-level approach was followed involving gene expression analysis, enzyme activity and metabolite measurements...
  68. pmc Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi
    Rodrigo Fernandez-Valdivia
    Brown Foundation Institute of Molecular Medicine IMM, The University of Texas Health Science Center, Houston, TX 77030, USA
    Development 138:1925-34. 2011
    ..Given that Rumi(-/-) embryos show more severe phenotypes compared to those displayed by other global regulators of canonical Notch signaling, Rumi is likely to have additional important targets during mammalian development...
  69. ncbi Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase
    H Qadota
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Science 272:279-81. 1996
    ..Both proteins were localized predominantly at sites of cell wall remodeling. Therefore, it appears that Rho1p is a regulatory subunit of beta(1-->3)glucan synthase...
  70. ncbi Expression of an Arabidopsis sucrose synthase gene indicates a role in metabolization of sucrose both during phloem loading and in sink organs
    T Martin
    Institut für Genbiologische Forschung Berlin GmbH, Berlin, Germany
    Plant J 4:367-77. 1993
    ..The expression pattern and regulation of the gene suggest that sucrose synthase is involved in the supply of energy for phloem loading in source tissues, and in metabolization of sucrose in sink tissues after unloading...
  71. pmc Organization of cellulose synthase complexes involved in primary cell wall synthesis in Arabidopsis thaliana
    Thierry Desprez
    Laboratoire de Biologie Cellulaire, Unité de Recherche 501, Institut Jean Pierre Bourgin Institut national de la recherche agronomique, Route de St Cyr, 78026 Versailles Cedex, France
    Proc Natl Acad Sci U S A 104:15572-7. 2007
    ..Participation of the latter three isoforms might fine-tune the CESA complexes for the deposition of microfibrils at distinct cellular growth stages...
  72. ncbi Carbon partitioning to cellulose synthesis
    C H Haigler
    Department of Biological Sciences, Texas Tech University, Lubbock 79409 3131, USA
    Plant Mol Biol 47:29-51. 2001
    ....
  73. ncbi The Cytophaga hutchinsonii ChTPSP: First characterized bifunctional TPS-TPP protein as putative ancestor of all eukaryotic trehalose biosynthesis proteins
    Nelson Avonce
    Department of Molecular Microbiology, VIB, Heverlee, Belgium
    Mol Biol Evol 27:359-69. 2010
    ....
  74. pmc The UDP-glucosyltransferase multigene family in Bombyx mori
    Fei Fei Huang
    The Key Sericultural Laboratory of Agricultural Ministry, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, PR China
    BMC Genomics 9:563. 2008
    ..Identification and characterization of Bombyx mori UGT genes could provide valuable basic information for this important family and explain the detoxication mechanism and other processes in insects...
  75. pmc Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis
    Shumpei Asamizu
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Am Chem Soc 133:12124-35. 2011
    ..The enzyme operates in sequence with a phosphatase, which dephosphorylates validoxylamine A 7'-phosphate to validoxylamine A...
  76. ncbi Localization of the (1,3)beta-D-glucan synthase catalytic subunit homologue Bgs1p/Cps1p from fission yeast suggests that it is involved in septation, polarized growth, mating, spore wall formation and spore germination
    Juan Carlos G Cortés
    Departamento de Microbiologia y Genetica, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    J Cell Sci 115:4081-96. 2002
    ....
  77. pmc Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
    Jessica Leonardi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:3569-78. 2011
    ....
  78. ncbi Over-expression of an Arabidopsis gene encoding a glucosyltransferase of indole-3-acetic acid: phenotypic characterisation of transgenic lines
    Rosamond G Jackson
    Department of Biology, University of York, PO Box 373, York YO10 5DD, UK
    Plant J 32:573-83. 2002
    An analysis of the multigene family of Group 1 glucosyltransferases (UGTs) of Arabidopsis thaliana revealed a gene, UGT84B1, whose recombinant product glucosylated indole-3-acetic acid (IAA) in vitro...
  79. pmc Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function
    S Katayama
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    J Cell Biol 144:1173-86. 1999
    ..These results indicate that Mok1 plays a crucial role in cell morphogenesis interdependently of the actin cytoskeleton and works as one of downstream effectors for Pck1/2...
  80. pmc Arabidopsis trehalose-6-phosphate synthase 1 is essential for normal vegetative growth and transition to flowering
    Anja J H van Dijken
    Department of Molecular Plant Physiology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Plant Physiol 135:969-77. 2004
    ..Moreover, tps1/tps1 plants are retarded in growth and remain generative during their lifetime. Absence of Trehalose-6-Phosphate Synthase 1 in Arabidopsis plants precludes transition to flowering...
  81. ncbi Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice
    Florence Bietrix
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:931-7. 2010
    ....
  82. ncbi Sucrose metabolism: regulatory mechanisms and pivotal roles in sugar sensing and plant development
    Karen Koch
    Plant Molecular and Cellular Biology Program, Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, USA
    Curr Opin Plant Biol 7:235-46. 2004
    ..The extent, path, and site of sucrose metabolism are thus highly responsive to both internal and external environmental signals and can, in turn, dramatically alter development and stress acclimation...
  83. pmc Novel plant immune-priming compounds identified via high-throughput chemical screening target salicylic acid glucosyltransferases in Arabidopsis
    Yoshiteru Noutoshi
    Research Core for Interdisciplinary Sciences, Okayama University, Kita ku, Okayama 700 8530, Japan
    Plant Cell 24:3795-804. 2012
    ..Inducing compounds inhibited two SA glucosyltransferases (SAGTs) in vitro...
  84. ncbi Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum
    D Warnecke
    Universitat Hamburg, Institut fur Allgemeine Botanik, 22609 Hamburg, Germany
    J Biol Chem 274:13048-59. 1999
    ..discoideum, the deduced amino acid sequences of which all showed similarities with plant sterol glucosyltransferases (Ugt80A1, Ugt80A2)...
  85. pmc Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila
    Ayako Kohyama-Koganeya
    Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako Shi, Saitama 351 0198, Japan
    J Lipid Res 52:1392-9. 2011
    ..Both GlcT-1 and p38-ATF2 signaling are evolutionarily conserved, leading us to propose an evolutionary perspective in which GlcT-1 appears to be one of the key factors that control fat metabolism...
  86. ncbi Phytochrome regulation of cellulose synthesis in Arabidopsis
    Volker Bischoff
    Institut Jean Pierre Bourgin, UMR1318 INRA AgroParisTech, 78026 Versailles, France
    Curr Biol 21:1822-7. 2011
    ....
  87. ncbi AGS3, an alpha(1-3)glucan synthase gene family member of Aspergillus fumigatus, modulates mycelium growth in the lung of experimentally infected mice
    D Maubon
    Aspergillus Unit, Institut Pasteur, Paris, France
    Fungal Genet Biol 43:366-75. 2006
    ..These results suggest an indirect role for AGS3 in virulence through an adaptive mechanism...
  88. ncbi Synthesis of alpha-glucans in fission yeast spores is carried out by three alpha-glucan synthase paralogues, Mok12p, Mok13p and Mok14p
    Ignacio Garcia
    Instituto de Microbiologia Bioquimica, CSIC Universidad de Salamanca and Departamento de Microbiología y Genética, Universidad de Salamanca Campus Miguel de Unamuno 37007 Salamanca, Spain
    Mol Microbiol 59:836-53. 2006
    ....
  89. pmc Purification, characterization, and molecular analysis of the gene encoding glucosyltransferase from Streptococcus oralis
    T Fujiwara
    Department of Pedodontics, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 68:2475-83. 2000
    ..These results indicate that S. oralis GTase may play an important role in the subsequent colonizing of mutans streptoccoci...
  90. pmc FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance
    Alicia J Zimbeck
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop G 11, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 54:5042-7. 2010
    ..With a rising number of echinocandin therapy failures reported, it is important to continue to monitor rates of elevated echinocandin MIC values and the associated mutations...
  91. ncbi Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi)
    Xiaofang Zhang
    Department of Pathology, Qilu Hospital, Institute of Pathology and Pathophysiology, Shandong University of Medicine, Jinan, Shandong, China
    Cancer Biol Ther 8:1117-21. 2009
    ..And the reversing effects could keep for a long period (at least 3 w). Our results demonstrated that co-inhibition of MDR1 and GCS could more effectively reverse MDR in drug resistant breast carcinoma cells in vitro...
  92. ncbi Identification of cariostatic substances in the cacao bean husk: their anti-glucosyltransferase and antibacterial activities
    K Osawa
    Central Laboratory, Lotte Co. Ltd, Saitama, Saitama, Japan
    J Dent Res 80:2000-4. 2001
    ..The cariostatic activity of the cacao bean husk is likely caused by these biologically active constituents...
  93. ncbi Keeping cell identity in Arabidopsis requires PRC1 RING-finger homologs that catalyze H2A monoubiquitination
    Fabian Bratzel
    Department of Biodiversity and Plant Systematics, Heidelberg Institute for Plant Science, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg, Germany
    Curr Biol 20:1853-9. 2010
    ..Our data demonstrate that the AtBMI1A/B proteins mediate H2A monoubiquitination in Arabidopsis and that this mark, together with PRC2-mediated H3K27 trimethylation, plays a key role in maintaining cell identity...
  94. ncbi Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth
    Steven B Levery
    Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA
    FEBS Lett 525:59-64. 2002
    ..fumigatus cultured in the presence of these inhibitors displayed a significantly reduced GlcCer/GalCer ratio. These results suggest that synthesis of GlcCer is essential for normal development of A. fumigatus and A. nidulans...
  95. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
    ..Our data show that cranberry PAC reduced the formation of biofilms by S. mutans in vitro and dental caries development in vivo, which may be attributed to the presence of specific bioactive A-type dimers and oligomers...
  96. ncbi Molecular analysis of the inhibitory effects of oolong tea polyphenols on glucan-binding domain of recombinant glucosyltransferases from Streptococcus mutans MT8148
    M Matsumoto
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    FEMS Microbiol Lett 228:73-80. 2003
    ..These results indicate that OTF6, a polymeric polyphenol specific for oolong tea is able to reduce glucan synthesis by inhibiting the GBD of S. mutans GTFB...
  97. pmc Distribution of callose synthase, cellulose synthase, and sucrose synthase in tobacco pollen tube is controlled in dissimilar ways by actin filaments and microtubules
    Giampiero Cai
    Dipartimento Scienze Ambientali G Sarfatti, Universita di Siena, 53100 Siena, Italy
    Plant Physiol 155:1169-90. 2011
    ....
  98. ncbi Cell wall glucomannan in Arabidopsis is synthesised by CSLA glycosyltransferases, and influences the progression of embryogenesis
    Florence Goubet
    Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, UK
    Plant J 60:527-38. 2009
    ..Together with earlier heterologous expression studies, the glucomannan deficiency observed in csla mutant plants demonstrates that the CSLA family encodes glucomannan synthases...
  99. ncbi Contributions of three glycosyltransferases to sucrose-dependent adherence of Streptococcus mutans
    T Ooshima
    Department of Pedodontics, Osaka University Graduate School of Dentistry, Suita, Japan
    J Dent Res 80:1672-7. 2001
    ..mutans, and that GTFC and GTFD may play significant roles in the synthesis of adhesive and insoluble glucan from sucrose...
  100. ncbi An update on the nomenclature for the cellulose synthase genes in Populus
    Manoj Kumar
    Umea Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish Agricultural University, Umea, Sweden
    Trends Plant Sci 14:248-54. 2009
    ..To help reduce the resulting confusion, we propose here a new phylogeny-based CesA nomenclature that aligns the Populus CesA gene family with the established Arabidopsis thaliana CesA family structure...
  101. ncbi Structure and expression profile of the sucrose synthase multigene family in Arabidopsis
    Sébastien Baud
    Unité de Biologie des Semences, UMR 204, INA PG INRA, RD 10, 78026 Versailles Cedex, France
    J Exp Bot 55:397-409. 2004
    ..These results add new insights on the expression of SUS genes and are discussed in relation to distinct functions for each member of the AtSUS family...

Research Grants52

  1. DISPERSION OF STREPTOCOCCUS MUTANS BIOFILMS BY A NOVEL SMALL MOLECULE
    SANDRA S GARCIA; Fiscal Year: 2013
    ..b>Glucosyltransferases (Gtfs) secreted by S...
  2. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2012
    ..mutans within biofilms involve, at least, three routes: (1) by inhibiting the activity and expression of glucosyltransferases, which are associated with the formation of the polysaccharide matrix in biofilms, (2) by affecting acid ..
  3. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..of cariogenic streptococci is the formation of glucan, which is synthesized by the catalytic action of MS glucosyltransferases (GTF) on sucrose...
  4. Regulation of gtf Gene Expression in S mutans
    Steven Goodman; Fiscal Year: 2005
    ..from dietary sucrose which allow the bacteria possesses a family of genes that express enzymes called glucosyltransferases (GTF). There are three GTFs in S. mutans...
  5. GENETICS OF ORAL MICROFLORA
    FRANCIS MACRINA; Fiscal Year: 2000
    ..Work will also continue on characterization of glucosyltransferases and glucan-binding proteins in S. mutans-induced dental caries...
  6. GLYCOSYLTRANSFERASES FROM ORAL BACTERIA
    KUMARI DEVULAPALLE; Fiscal Year: 1999
    ..and focusses on experimental approaches designed to understand the molecular structure and mechanism of glucosyltransferases (GTFs) expressed by oral bacteria commonly referred to as mutans streptococci...
  7. Approach to control caries through apple-derived vaccine
    Hilary Koprowski; Fiscal Year: 2006
    ..Agl/ll coupled to cholera toxin (CT) A2 and B subunits (CTA2B) and/or glucan-binding (GLU) protein of glucosyltransferases (GTF) for Agrobacterium-mediated transformation, to obtain transgenic apple line to express SBR-CTA2B and/..
  8. POLYPHENOL OXIDASES AS ANTIADHESINS
    RONALD DOYLE; Fiscal Year: 1999
    ..Define how the PPO inhibits the glucan-binding lectins and glucosyltransferases of the streptococci. 2...
  9. CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITY
    Daniel Smith; Fiscal Year: 2007
    ..unreadable]..
  10. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ..Apigenin is a potent inhibitor of glucosyltransferases (GTFs), both in solution and on a surface (60-95% inhibition at 1...
  11. LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITY
    Noel Childers; Fiscal Year: 2001
    ....
  12. SYNTHETIC PEPTIDE VACCINES FOR DENTAL CARIES
    Martin Taubman; Fiscal Year: 2005
    ..We have previously identified several glucosyltransferases (GTF) enzyme sequences which can induce immune response in rodents which will alter GTF activity and reduce ..
  13. X-ray Structure of Human Aldehyde Dehydrogenase
    Thomas Hurley; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. Structural Determinants of Glycogen Initiation
    Thomas Hurley; Fiscal Year: 2006
    ..4) Test the proposed roles for specific residues in the active site of glycogenin during catalysis and for the recognition of substrate and acceptor molecules. [unreadable] [unreadable]..
  15. Expression of Cell Surface Proteins in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2007
    ..mutans will provide opportunities for the development of new approaches to the prevention and treatment of dental caries. [unreadable] [unreadable] [unreadable]..
  16. GLUCAN BINDING PROTEINS OF ORAL STREPTOCOCCI
    Jeffrey Banas; Fiscal Year: 2007
    DESCRIPTION: Streptococcus mutans possesses three distinct glucosyltransferases (GTFs) and at least three different nonenzymatic glucan binding proteins (GBPs)...
  17. ENERGY COUPLING BY THE YEAST PLASMA MEMBRANE H+_ATPASE
    David Perlin; Fiscal Year: 2004
    ..abstract_text> ..
  18. SHIGA TOXIN MODE OF ACTION IN BACTERIAL DISEASE
    Tom Obrig; Fiscal Year: 2007
    ..The goal of these studies is to reveal the opportunities available for effective application of therapeutic agents in STEC-associated renal disease. ..
  19. Patterns of ganglioside expression in neuroblastoma
    Karen Kaucic; Fiscal Year: 2003
    ....
  20. Sleep Mechanisms in Children: Role of Metabolism
    Gabriel Haddad; Fiscal Year: 2002
    ..As seen from reviewing the state-of-the-art above, there are major gaps in our knowledge and this application focuses on a number of these gaps. ..
  21. NEW THERAPEUTICS FOR PATHOGENIC E-COLI DISEASES
    Tom Obrig; Fiscal Year: 2007
    ..coli 0157:H7-associated disease will be further defined using A2A receptor deficient mice and adoptive bone marrow transfer to determine the role of circulating inflammatory cells in this disease. [unreadable] [unreadable]..
  22. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle. ..
  23. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  25. Electrogenic glucose sensor of neuromuscular junction
    Andrew Voss; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  26. Interspecies Streptococcal Antagonisms in Oral Biofilms
    Jens Kreth; Fiscal Year: 2008
    ..mutans. [unreadable] [unreadable] [unreadable]..
  27. Hypoxia and Consequences: From Molecule to Malady
    Gabriel Haddad; Fiscal Year: 2008
    ..The meeting will bring together experts from a variety of different backgrounds and fields to discuss this important unifying theme. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  28. Identification of compounds that protect HERG from block by proarrhythmic agents
    Sabina Kupershmidt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Pheromone Signaling in Pneumocystis Carinii
    Charles Thomas; Fiscal Year: 2009
    ..Through these investigations we hope to gain insights into P. carinii biology which may provide new information for novel drug development to treat PCP. ..
  30. Mechanism of Pseudomonas-mediated epithelial cell damage
    Joanne N Engel; Fiscal Year: 2010
    ..It opens up the possibility of targeting host cell processes to treat infectious diseases. ..
  31. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  32. Control of virulence in Neisseria meningitidis
    Yih Ling Tzeng; Fiscal Year: 2009
    ..meningitidis and are important to the development of new approaches for meningococcal disease prevention and treatment. ..
  33. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  34. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
    ..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
  35. NEW METHODS FOR QUANTITATIVE GLYCOSPHINGOLIPIDOMICS
    STEVEN LEVERY; Fiscal Year: 2005
    ....
  36. High Purity Amphotericin B: A Safer Antimycotic in AIDS
    John Cleary; Fiscal Year: 2005
    ..abstract_text> ..
  37. New approaches to studying host-chlamydia interactions
    Joanne Engel; Fiscal Year: 2006
    ..trachomatis infection. Together, these studies will significantly advance our knowledge of infectious disease pathogenesis and pave the way for new therapies and vaccines. ..
  38. Defective trafficking Mechanisms in a Cardiac K+ Channel
    Sabina Kupershmidt; Fiscal Year: 2006
    ..We will develop novel therapeutic strategies designed to correct intracellular processing steps of HERG and possibly other plasma membrane proteins that suffer from defects caused by the same mechanism. ..
  39. GENERAL CLINICAL RESEARCH CENTER
    David Kessler; Fiscal Year: 2006
    ..As we do so, we will continue to perform this research with the highest standards of patient care, ethics, safety and regulatory compliance. ..
  40. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
    ..b>Glucosyltransferases (Gff, E.C. 2.4.1...
  41. MOLECULAR BASIS OF CELL TOLERANCE TO 02 DEPRIVATION
    Gabriel Haddad; Fiscal Year: 2009
    ..g., mammalian) to render them resistant ..
  42. HORMONAL CONTROL OF GLYCOGEN METABOLISM
    Peter Roach; Fiscal Year: 2004
    ..We will also attempt to assess in animal models the roles of phosphorylation and G6P activation of GS in controlling glycogen synthesis ..
  43. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 2005
    ..Yeast has proven to be a useful experimental system to study vesicular trafficking and such may be true for the study of autophagy and its relationship to glycogen metabolism (aim iii). ..
  44. LIPID METABOLISM IN HUMAN KERATINOCYTES
    KATHI MADISON; Fiscal Year: 2004
    ..Ultimately, these studies will contribute to fundamental knowledge about the regulation of epidermal differentiation at the molecular level. ..
  45. CYCLICAL HYPOXIA--SUSCEPTIBILITY TO NEURONAL INJURY
    Gabriel Haddad; Fiscal Year: 2003
    ..This work may shed light on mechanisms of a variety of diseases, including OSAH, apnea of infancy, postnatal cardiorespiratory diseases that reduce O2 delivery, myocardial infarcts, and cerebro-vascular accidents and stroke. ..
  46. BIOGENESIS OF THE CHLAMYDIA TRACHOMATIS VACUOLE
    Joanne Engel; Fiscal Year: 2004
    ..trachomatis vacuole. This will help to further define the pathway involved. These studies may lead to the development of new anti-chlamydial drug therapies and further our understanding of lipid trafficking in eukaryotic cells. ..
  47. Pharmacogenomics/natural products + antifungal activity
    John Cleary; Fiscal Year: 2004
    ..Probing this array with eukaryotic mRNA from cells exposed to novel antifungals would predict common mechanism of action and likelihood of toxicity, activity and resistance. ..