arylalkylamine n acetyltransferase

Summary

Summary: An acetyltransferase with specificity towards the amine group of aromatic alkylamines (arylalkylamines) such as SEROTONIN. This enzyme is also referred to as serotonin acetylase despite the fact that serotonin acetylation can also occur through the action of broad specificity acetyltransferases such as ARYLAMINE N-ACETYLTRANSFERASE.

Top Publications

  1. pmc Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87)
    Jiri Pavlicek
    Section of Neuroendocrinology, Program on Developmental Endocrinology and Genetics, NIH, Bethesda, MD 20892, USA
    J Biol Chem 283:14552-8. 2008
  2. ncbi Arylalkylamine N-acetyltransferase: "the Timezyme"
    David C Klein
    Section on Neuroendocrinology, Office of Scientific Director, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4233-7. 2007
  3. doi Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle, Germany
    J Pineal Res 45:439-48. 2008
  4. pmc Evolution of arylalkylamine N-acetyltransferase: emergence and divergence
    Steven L Coon
    Section on Neuroendocrinology, Office of the Scientific Director, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20894, USA
    Mol Cell Endocrinol 252:2-10. 2006
  5. ncbi Duality of serotonin-N-acetyltransferase in the gilthead seabream (Sparus aurata): molecular cloning and characterization of recombinant enzymes
    Bina Zilberman-Peled
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Gen Comp Endocrinol 138:139-47. 2004
  6. ncbi Melatonin pathway: breaking the 'high-at-night' rule in trout retina
    Laurence Besseau
    Laboratoire Arago, Université P and M Curie UPMC and CNRS, UMR 7628, BP44, 66651 Banyuls Mer Cedex, France
    Exp Eye Res 82:620-7. 2006
  7. ncbi Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements
    Lior Appelbaum
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Endocrinol 18:1210-21. 2004
  8. ncbi Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes
    So Young Lee
    Division of Molecular and Life Science, National Core Research Center for System Bio Dynamics, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Am J Physiol Cell Physiol 290:C1060-6. 2006
  9. ncbi Morphological and biochemical study of the pineal gland of pregnant and non-pregnant female vizcachas (Lagostomus maximus maximus)
    Esteban Gil
    Area de Morfologia, Universidad Nacional de San Luis, San Luis, Argentina
    Neuro Endocrinol Lett 26:575-80. 2005
  10. ncbi Diurnal and circadian rhythms in melatonin synthesis in the turkey pineal gland and retina
    Jolanta B Zawilska
    Centre for Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Gen Comp Endocrinol 145:162-8. 2006

Detail Information

Publications178 found, 100 shown here

  1. pmc Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87)
    Jiri Pavlicek
    Section of Neuroendocrinology, Program on Developmental Endocrinology and Genetics, NIH, Bethesda, MD 20892, USA
    J Biol Chem 283:14552-8. 2008
    ..The structural kink and local rigidity imposed by Pro-64 may enhance activity by favoring configurations of Loop 1 that facilitate catalysis and do not become immobilized by intramolecular interactions...
  2. ncbi Arylalkylamine N-acetyltransferase: "the Timezyme"
    David C Klein
    Section on Neuroendocrinology, Office of Scientific Director, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4233-7. 2007
    ..This activates the enzyme and prevents proteosomal proteolysis. The conserved features of regulatory systems that control arylalkylamine N-acetyltransferase are a circadian clock and environmental lighting...
  3. doi Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University, Halle Wittenberg, Halle, Germany
    J Pineal Res 45:439-48. 2008
    ..The results thus prove that a melatonin-insulin antagonism exists. Astonishingly, notwithstanding the drastic metabolic disturbances in STZ-diabetic rats, the diurnal rhythms of the parameters investigated are maintained...
  4. pmc Evolution of arylalkylamine N-acetyltransferase: emergence and divergence
    Steven L Coon
    Section on Neuroendocrinology, Office of the Scientific Director, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20894, USA
    Mol Cell Endocrinol 252:2-10. 2006
    ..Lastly, a third AANAT gene has been found in teleost fish, suggesting that AANAT genes serve multiple functions in addition to melatonin synthesis...
  5. ncbi Duality of serotonin-N-acetyltransferase in the gilthead seabream (Sparus aurata): molecular cloning and characterization of recombinant enzymes
    Bina Zilberman-Peled
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Gen Comp Endocrinol 138:139-47. 2004
    ..In addition, retinal AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin...
  6. ncbi Melatonin pathway: breaking the 'high-at-night' rule in trout retina
    Laurence Besseau
    Laboratoire Arago, Université P and M Curie UPMC and CNRS, UMR 7628, BP44, 66651 Banyuls Mer Cedex, France
    Exp Eye Res 82:620-7. 2006
    ....
  7. ncbi Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements
    Lior Appelbaum
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Endocrinol 18:1210-21. 2004
    ..These results indicate that pineal specificity of zfaanat-2 is determined by the dual functionality of the PRDM and the interaction between upstream regulatory region and downstream photoreceptor conserved elements and E-box element...
  8. ncbi Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes
    So Young Lee
    Division of Molecular and Life Science, National Core Research Center for System Bio Dynamics, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Am J Physiol Cell Physiol 290:C1060-6. 2006
    ..Collectively, these results suggest that NE triggers Ca(2+) entry coupled to BK channels and that NE-induced Ca(2+) entry is important in the regulation of AANAT...
  9. ncbi Morphological and biochemical study of the pineal gland of pregnant and non-pregnant female vizcachas (Lagostomus maximus maximus)
    Esteban Gil
    Area de Morfologia, Universidad Nacional de San Luis, San Luis, Argentina
    Neuro Endocrinol Lett 26:575-80. 2005
    ..The morphological and biochemical aspects of the pineal gland of pregnant and non-pregnant female vizcachas were investigated to examine whether there is a relationship between the pregnancy and this gland...
  10. ncbi Diurnal and circadian rhythms in melatonin synthesis in the turkey pineal gland and retina
    Jolanta B Zawilska
    Centre for Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Gen Comp Endocrinol 145:162-8. 2006
    ..The rapid dampening of the rhythms under DD suggests that of these two regulatory factors, environmental light may be the primary stimulus in the maintenance of the high amplitude melatonin rhythms in the turkey...
  11. ncbi Mechanisms regulating melatonin synthesis in the mammalian pineal organ
    Christof Schomerus
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 6059 Frankfurt Main, Germany
    Ann N Y Acad Sci 1057:372-83. 2005
    ..This diversity has emerged in the course of evolution and reflects the high adaptive plasticity of the melatonin-generating pineal organ...
  12. ncbi Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status
    Elmar Peschke
    Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Pineal Res 40:135-43. 2006
    ..Our observations suggest a functional inter-relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes...
  13. ncbi Starting the zebrafish pineal circadian clock with a single photic transition
    Robin Vuilleumier
    Laboratoire Arago, Observatoire Océanologique de Banyuls, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7628, Universite de Paris VI, Banyuls mer, France
    Endocrinology 147:2273-9. 2006
    ....
  14. ncbi Suppression of serotonin N-acetyltransferase transcription and melatonin secretion from chicken pinealocytes transfected with Bmal1 antisense oligonucleotides containing locked nucleic acid in superfusion system
    Zoltan Rekasi
    Department of Anatomy, University of Pecs, and Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, Pecs 7624, Hungary
    Mol Cell Endocrinol 249:84-91. 2006
    ..The superfusion cell culture with reduced transfection toxicity may provide a useful tool for antisense drug design to influence the highly conserved clockwork also in man...
  15. ncbi Characterization of human melatonin synthesis using autoptic pineal tissue
    Katrin Ackermann
    Institute of Anatomy III, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Endocrinology 147:3235-42. 2006
    ..In particular, our results give strong experimental support for the idea that transcriptional mechanisms are not dominant for the generation of rhythmic melatonin synthesis in the human pineal gland...
  16. ncbi Circadian expression of Bmal1 and serotonin-N-acetyltransferase mRNAs in chicken retina cells and pinealocytes in vivo and in vitro
    Gabor L Toller
    Department of Anatomy, University of Pecs, and Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, Pecs, Hungary
    J Mol Neurosci 28:143-50. 2006
    ..Based on the highly conserved nature of the clockwork, it is reasonable to consider that chicken retina and pineal gland might serve as a useful tool for the development of drugs that could influence clock function in man...
  17. ncbi Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands
    Sung Han
    System Bio Dynamics NCRC, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Biol Chem 280:38228-34. 2005
    ..Our results suggest that bradykinin-induced calcium inhibits melatonin synthesis through the mediation of adenylyl cyclase type 6 expression...
  18. ncbi Effects of the blockade of high voltage-activated calcium channels on in vitro pineal melatonin synthesis
    Solange C Afeche
    Laboratory of Pharmacology, Butantan Institute, Av Vital Brazil, 1500 Sao Paulo, SP 05503 900, Brazil
    Cell Biochem Funct 24:499-505. 2006
    ..However, the mechanisms involved in this process are different for the L- or P/Q- and N-type calcium channels...
  19. ncbi Differential regulation of melatonin synthesis genes and phototransduction genes in embryonic chicken retina and cultured retinal precursor cells
    Virginie Cailleau
    UMR CNRS 6187 Institut de Physiologie et Biologie Cellulaires, Poitiers, France
    Mol Vis 11:472-81. 2005
    ....
  20. ncbi Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis
    C Schomerus
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
    J Neuroendocrinol 16:741-9. 2004
    ..The study is of particular interest because regulation of melatonin biosynthesis in bovines may resemble that in primates more closely than that in rodents...
  21. ncbi Retinal ganglion cells are autonomous circadian oscillators synthesizing N-acetylserotonin during the day
    Eduardo Garbarino-Pico
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba 5000, Argentina
    J Biol Chem 279:51172-81. 2004
    ..These rhythms were also observed after the application of glutamate. The results demonstrate that chick retinal ganglion cells may function as autonomous circadian oscillators synthesizing a melatonin-like indole during the day...
  22. ncbi Day/night fluctuations in melatonin content, arylalkylamine N-acetyltransferase activity and NAT mRNA expression in the CNS, peripheral tissues and hemolymph of the cockroach, Periplaneta americana
    Jadwiga Bembenek
    Graduate School of Science and Technology, Kobe University, Rokkoda cho 1 1, Nada, Kobe 657 8501, Japan
    Comp Biochem Physiol B Biochem Mol Biol 140:27-36. 2005
    ..The results in the brain led to the conclusion that NAT could be a clock-controlled gene functioning as an output regulator of the circadian clock...
  23. ncbi Environmental control and adrenergic regulation of pineal activity in the diurnal tropical rodent, Arvicanthis ansorgei
    Marie Laure Garidou-Boof
    Laboratoire de Neurobiologie des Rythmes, UMR 7518 CNRS Université Louis Pasteur, Strasbourg, France
    J Pineal Res 38:189-97. 2005
    ....
  24. ncbi Pineal circadian clocks gate arylalkylamine N-acetyltransferase gene expression in the mouse pineal gland
    Chiaki Fukuhara
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Neurochem 93:156-62. 2005
    ..Our results suggest that the pineal circadian clock may determine timing when Aa-Nat gene expression can respond to inputs from the master circadian clock in the suprachiasmatic nucleus, e.g. adrenergic stimulation...
  25. pmc Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation
    Tae Don Kim
    National Research Laboratory, Department of Life Science, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Kyung Buk 790 784, Republic of Korea
    Mol Cell Biol 25:3232-46. 2005
    ....
  26. ncbi Near-ultraviolet light perceived by the retina generates the signal suppressing melatonin synthesis in the chick pineal gland-an involvement of NMDA glutamate receptors
    Jolanta Rosiak
    Centre for Medical Biology, Polish Academy of Sciences, 106 Lodowa St, 93 232 Łódź, Poland
    Neurosci Lett 379:214-7. 2005
    ..At the level of the retina, such signal does not involve dopamine, but is dependent on the stimulation of NMDA glutamate receptors...
  27. ncbi Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87)
    Steven L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    J Clin Endocrinol Metab 87:4699-706. 2002
    ..The discovery in this study that rhesus pineal AANAT mRNA is high at all times is of special importance because it shows that posttranscriptional control of this enzyme plays a dominant role in regulating melatonin synthesis...
  28. ncbi Functional development of the zebrafish pineal gland: light-induced expression of period2 is required for onset of the circadian clock
    L Ziv
    Department of Zoology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Neuroendocrinol 17:314-20. 2005
    ..These experiments indicated that light-induced zper2 expression is crucial for establishment of the clock-controlled zfaanat2 rhythm in the zebrafish pineal gland...
  29. ncbi A new strain of rat for functional analysis of PINA
    Samreen Ahmed
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, 7629 MS II, 1301 East Catherine Street, Ann Arbor, MI 48109 0622, USA
    Brain Res Mol Brain Res 137:63-9. 2005
    ..The separation of PINA mutation from both NAT and coat color mutations in the new LPP rats will permit better functional studies of PINA in pineal circadian physiology...
  30. ncbi [Regulatory mechanism of melatonin synthesis in pineal gland: regulation of serotonin N-acetyltransferase activity]
    Seiji Tsuboi
    Department of Pharmacy, School of Pharmacy, Shujitsu University, Nishigawara, Okayama, Japan
    Seikagaku 77:411-5. 2005
  31. ncbi Period2 expression pattern and its role in the development of the pineal circadian clock in zebrafish
    Limor Ziv
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Chronobiol Int 23:101-12. 2006
    ..Thus, a possible role for early photoreception and light-induced zper2 expression in the development of clock-controlled rhythms remains to be investigated...
  32. ncbi Daily torpor alters multiple gene expression in the suprachiasmatic nucleus and pineal gland of the Djungarian hamster (Phodopus sungorus)
    Annika Herwig
    Département de Neurobiologie des Rythme, Institut des Neurosciences Cellulaires et Integratives, Universite Louis Pasteur, IFR des Neurosciences de Strasbourg, France
    Chronobiol Int 23:269-76. 2006
    ..Furthermore, the rhythmic gene expression in a peripheral oscillator, the pineal gland, is also affected...
  33. ncbi Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells
    M Fevre-Montange
    INSERM, U842, Universite de Lyon, Faculte de Medecine Laennec, UMR S842, Lyon, France
    Neuropathol Appl Neurobiol 34:296-305. 2008
    ..Moreover, PTPR never expressed mRNA encoding TPH, AANAT and HIOMT. Our results may contribute to a better understanding of the biology of PTT and PTPR and may help to the diagnosis of these rare tumours...
  34. pmc De novo discovery of serotonin N-acetyltransferase inhibitors
    Lawrence M Szewczuk
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Med Chem 50:5330-8. 2007
    ..Overall, this study demonstrates the feasibility of using virtual screening to identify small molecules that are selective inhibitors of AANAT...
  35. ncbi Dopamine-melatonin neurons in the avian hypothalamus controlling seasonal reproduction
    S W Kang
    Department of Animal Science, University of Minnesota, St Paul, MN 55108, USA
    Neuroscience 150:223-33. 2007
    ..These findings may form the basis for an endogenous dual-oscillator circadian system within PMM DA-MEL co-localized neurons controlling reproductive seasonality in birds...
  36. ncbi Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland
    Rodrigo Antonio Peliciari Garcia
    University of Sao Paulo, Institute of Biomedical Sciences, Department of Physiology and Biophysics, Av Prof Lineu Prestes 1524, 1st Floor, Room 118, Sao Paulo, SP, CEP 05508 900, Brazil
    Life Sci 82:108-14. 2008
    ..We conclude that insulin potentiates NE-mediated melatonin synthesis in cultured rat pineal gland, potentially through post-transcriptional events...
  37. ncbi Role of melatonin in upper gastrointestinal tract
    S J Konturek
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:23-52. 2007
    ..This review concentrates on the generation and pathophysiological implication of melatonin in upper GIT...
  38. doi Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland
    Roseli Barbosa
    Laboratory of Pharmacology, Butantan Institute, Sao Paulo, SP, Brazil
    Life Sci 82:529-35. 2008
    ..Thus, it seems that the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland...
  39. doi Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland
    Lin Bai
    Department of Molecular and Cellular Anatomy, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Brain Res 1203:89-96. 2008
    ....
  40. doi Fetal/placental regulation of maternal melatonin in rats
    Hiroshi Tamura
    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Pineal Res 44:335-40. 2008
    ..In conclusion, maternal circulating melatonin is from the maternal pineal gland and is increased by placental hormones during pregnancy...
  41. doi Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites
    R Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Cell Mol Life Sci 65:2001-18. 2008
    ..Moreover, melatonin is a source of bioactive metabolites, such as 5-methoxytryptamine, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine and N(1)-acetyl-5-methoxykynuramine...
  42. ncbi The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression
    S L Coon
    Section on Neuroendocrinology, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 34:76-84. 1996
    ..Brain and pituitary AA-NAT could modulate serotonin-dependent aspects of human behavior and pituitary function...
  43. pmc Novel functions for Period 3 and Exo-rhodopsin in rhythmic transcription and melatonin biosynthesis within the zebrafish pineal organ
    Lain X Pierce
    Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Brain Res 1223:11-24. 2008
    ..This work identifies novel roles for Exorh and Per3, and gives insight into potential interactions between the sensory and circadian systems within the pineal...
  44. ncbi [Photoperiodic control of melatonin synthesis in fish pineal and retina]
    Laurence Besseau
    Laboratoire Arago, UPMC and CNRS, UMR 7628 GDR2821, Banyuls sur Mer, France
    J Soc Biol 201:13-20. 2007
    ..This review summarizes our current knowledge on the molecular and cellular mechanisms of the rhythmic control of production of an important circadian clock messenger, underlying their plasticity...
  45. ncbi Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors
    Marco Koch
    Dr Senckenbergische Anatomie, Anatomisches Institut II, Fachbereich Medizin der Johann Wolfgang Goethe Universität, Frankfurt Main, Germany
    J Neurochem 98:267-78. 2006
    ..Taken together, our data strongly suggest that cannabinoids inhibit AANAT activity and attenuate melatonin biosynthesis through intracellular actions without involvement of classical cannabinoid receptor-dependent signaling cascades...
  46. ncbi [14-3-3 proteins--a role in the regulation of melatonin biosynthesis]
    Jolanta Rosiak
    Centrum Biologii Medycznej Polskiej Akademii Nauk w Lodzi, Lodz
    Postepy Biochem 52:35-41. 2006
    ....
  47. ncbi Nocturnal melatonin synthesis: how to stop it
    Jack Falcon
    Laboratoire Arago, Unité Mixte de Recherche 7628 Groupement de Recherche 2821, Université Pierre et Marie Curie and Centre National de la Recherche Scientifique, F 66651 Banyuls sur Mer, Cedex, France
    Endocrinology 148:1473-4. 2007
  48. ncbi Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina
    Gianluca Tosini
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Chronobiol Int 23:381-91. 2006
    ..Finally, it is important to mention that AANAT, in addition to its role in melatonin synthesis, may play a detoxification role in the vertebrate retina by acetylating arylalkylamines that may react with retinaldehyde...
  49. pmc Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro
    C L M Silva
    Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Br J Pharmacol 151:195-205. 2007
    ..The purpose of this investigation was to extend this observation to an in vivo condition and to explore the mechanism of action of melatonin...
  50. ncbi Nocturnal patterns and up-regulated excretion of the melatonin metabolite 6-sulfatoxymelatonin in the diurnal rodent Psammomys obesus post-weaning under a short photoperiod
    Alina Neuman
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Comp Biochem Physiol A Mol Integr Physiol 142:297-307. 2005
    ..Possibly, this pattern may be physiologically important to facilitate T(b) maintenance in the cold nights of winter in the desert...
  51. pmc Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production
    Tae Don Kim
    Department of Life Science, Division of Molecular and Life Sciences, Systems Bio Dynamics NCRC, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Genes Dev 21:797-810. 2007
    ..This translational regulation of AANAT mRNA provides a novel aspect for achieving the circadian rhythmicity of vertebrate melatonin...
  52. ncbi Cloning and early expression pattern of two melatonin biosynthesis enzymes in the turbot (Scophthalmus maximus)
    Robin Vuilleumier
    Biozentrum, University of Basel, Cell and Developmental Biology, Basel, Switzerland
    Eur J Neurosci 25:3047-57. 2007
    ..This is in marked contrast with the situation observed with zebrafish Aanat2, indicating that the molecular mechanisms controlling the development of the pineal melatonin system have been modified during the evolution of Teleost...
  53. ncbi Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT)
    S J Konturek
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 58:381-405. 2007
    ..This review concentrates on the generation and pathophysiological implication of MT in GIT and related organs...
  54. ncbi Photoperiod-dependent changes in melatonin synthesis in the turkey pineal gland and retina
    J B Zawilska
    Centre for Medical Biology, Polish Academy of Sciences, Lodz, 93 232, Poland
    Poult Sci 86:1397-405. 2007
    ..These findings show that in the turkey, photoperiod plays an important role in regulating the melatonin signal...
  55. doi Food deprivation and refeeding effects on pineal indoles metabolism and melatonin synthesis in the rainbow trout Oncorhynchus mykiss
    Rosa M Ceinos
    Departamento de Bioloxia Funcional e Ciencias da Saude, Edificio de Ciencias Experimentais, Facultade de Bioloxia, Universidade de Vigo, Vigo, Pontevedra, Spain
    Gen Comp Endocrinol 156:410-7. 2008
    ..The results show that food deprivation impairs daily rhythms of melatonin content in trout pineal organ by affecting the activity of melatonin synthesizing enzymes rather than by a deficiency in substrate availability...
  56. ncbi Identification of specific histidine residues and the carboxyl terminus are essential for serotonin N-acetyltransferase enzymatic activity
    C M Craft
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California School, 1333 San Pablo Street, BMT 401, Los Angeles, CA, USA
    Brain Res Mol Brain Res 75:198-207. 2000
    ..In light of the recently reported three-dimensional structure of AA-NAT (17,18), the site-directed mutagenesis data demonstrate experimentally the importance of essential amino acid residues for acetyl CoA binding and AA-NAT activation...
  57. ncbi The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland
    D C Klein
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    Recent Prog Horm Res 52:307-57; discussion 357-8. 1997
    ..The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates...
  58. ncbi Daily oscillation in melatonin synthesis in the Turkey pineal gland and retina: diurnal and circadian rhythms
    Jolanta B Zawilska
    Center for Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Chronobiol Int 23:341-50. 2006
    ..The findings suggest that environmental light may be of primary importance in the maintenance of the high-amplitude melatonin rhythms in the turkey...
  59. ncbi Signal transmission from the suprachiasmatic nucleus to the pineal gland via the paraventricular nucleus: analysed from arg-vasopressin peptide, rPer2 mRNA and AVP mRNA changes and pineal AA-NAT mRNA after the melatonin injection during light and dark per
    Yoshiaki Isobe
    Department of Neuro physiology and Brain Sciences, Nagoya City University, Graduate School of Medical Sciences, Mizuho, Nagoya 467 8601, Japan
    Brain Res 1013:204-11. 2004
    ..These results might suggest that the different responses to melatonin in the pineal gland during the light and dark periods was originated in the changes of Per2 in the PVN via SCN...
  60. ncbi Properties of an arylalkylamine N-acetyltransferase from the nematode, Ascaridia galli
    R Muimo
    Department of Pure and Applied Biology, University of Leeds, U K
    Comp Biochem Physiol B 106:969-76. 1993
    ....
  61. ncbi The 2004 Aschoff/Pittendrigh lecture: Theory of the origin of the pineal gland--a tale of conflict and resolution
    David C Klein
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    J Biol Rhythms 19:264-79. 2004
    ..High levels of AANAT in the latter tissue might serve the same function AANAT had when first acquired- prevention of A2AA formation...
  62. ncbi Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organ culture
    Marcin Nowicki
    Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Folia Histochem Cytobiol 40:9-16. 2002
    ..The results of morphological study are in agreement with the obtained biochemical data and point to the increase in secretory and metabolic activity of the rat pinealocytes in response to VIP...
  63. ncbi Expression of luteinizing hormone/chorionic gonadotropin receptor in the rat pineal gland
    Masanori T Itoh
    Department of Chemistry, St Marianna University School of Medicine, Sugao, Miyamae ku, Kawasaki, Japan
    J Pineal Res 41:35-41. 2006
    ..In addition, LH/CG receptor levels in the pineal gland are regulated during the estrous cycle under normal physiological conditions...
  64. ncbi Regulation of the expression of serotonin N-acetyltransferase gene in Japanese quail (Coturnix japonica): I. Rhythmic pattern and effect of light
    H Kato
    Faculty of Agriculture, Utsunomiya University, Mine machi, Utsunomiya, Japan
    J Pineal Res 27:24-33. 1999
    ..Darkness during the day did not increase the pineal AANAT mRNA levels. However, unexpected light-exposure for 2 hr just after lights-off blocked the increase in AANAT mRNA, and at midnight remarkably decreased AANAT mRNA by 50%...
  65. ncbi Retinal illumination phase shifts the circadian rhythm of serotonin N-acetyltransferase activity in the chicken pineal gland
    Jolanta B Zawilska
    Department of Pharmacology, Medical University of Łódź, Łódź, 90 151, Poland
    Neurosci Lett 360:153-6. 2004
    ..Our results suggest that in the chicken retinally perceived light provides a powerful and important signal for synchronization of circadian rhythmicity in the pineal gland...
  66. ncbi Characterization of the serotoninergic system in the C57BL/6 mouse skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
    Eur J Biochem 270:3335-44. 2003
    ....
  67. ncbi Molecular cloning of the arylalkylamine-N-acetyltransferase and daily variations of its mRNA expression in the Syrian hamster pineal gland
    F Gauer
    Neurobiologie des Fonctions Rythmiques et Saisonnieres, CNRS UMR 7518, Universite Louis Pasteur, 12 rue de l Université, 67000, Strasbourg, France
    Brain Res Mol Brain Res 71:87-95. 1999
    ..This result thus suggests that the transcription of the AA-NAT mRNA in the Syrian pineal gland determines the lag period in pineal responsiveness and melatonin synthesis to darkness...
  68. doi The rat pineal gland comprises an endocannabinoid system
    Marco Koch
    Institut für Anatomie II, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Pineal Res 45:351-60. 2008
    ..In summary, the pineal gland comprises indispensable compounds of the endocannabinoid system indicating that endocannabinoids may be involved in the control of pineal physiology...
  69. ncbi Demonstration of nerve fibers immunoreactive to peptide N-terminal histidine C-terminal isoleucine (PHI) and vasoactive intestinal peptide (VIP) in the pig pineal gland
    Marcin Nowicki
    Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Folia Histochem Cytobiol 41:141-7. 2003
    ..In the parenchyma, PHI- and VIP-immunoreactive nerve terminals created baskets around clusters of pinealocytes. No PHI- or VIP-immunopositive cells were found in the pig pineal gland...
  70. doi Nocturnal activation of aurora C in rat pineal gland: its role in the norepinephrine-induced phosphorylation of histone H3 and gene expression
    D M Price
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 150:2334-41. 2009
    ..This phenomenon suggests that activation of this mitotic kinase can be induced by extracellular signals to participate in the transcriptional induction of a subset of genes in the rat pineal gland...
  71. ncbi Biochemical characterization of recombinant serotonin N-acetyltransferase
    X Zhan-Poe
    Doheny Eye Institute, Department of Cell and Neurobiology, University of Southern California School of Medicine, Los Angeles 90033, USA
    J Pineal Res 27:49-58. 1999
    ..These data also suggest that the phosphorylation status of the AA-NAT does not affect enzymatic activity directly, and histidine residues are potentially important residues required for high catalytic activity...
  72. ncbi Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms
    Stephanie Perreau-Lenz
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, Netherlands
    Eur J Neurosci 17:221-8. 2003
    ..Combination of inhibitory and stimulatory SCN outputs could be of a great interest for the mechanism of adaptation to day-length (i.e. adaptation to seasons)...
  73. ncbi Suppression of melatonin biosynthesis in the chicken pineal gland by retinally perceived light - involvement of D1-dopamine receptors
    Jolanta B Zawilska
    Department of Biogenic Amines, Polish Academy of Sciences, Lodz Department of Pharmacology, Medical University of Lodz, Lodz, Poland
    J Pineal Res 36:80-6. 2004
    ....
  74. ncbi Day/night variation of tryptophan hydroxylase and serotonin N-acetyltransferase mRNA levels in the ovine pineal gland and retina
    K Privat
    INSERM U433, Faculté R Th Laënnec, Lyon, France
    J Pineal Res 26:193-203. 1999
    ..Our results suggest that, in the sheep, post-transcriptional mechanisms might also be involved in the day/night modulation of melatonin production...
  75. ncbi In vitro effects of steroid hormones on arylalkylamine N-acetyltransferase (AA-NAT) activity in the pineal of fish, Clarias gariepinus (Burchell, 1822) during different phases of breeding cycle
    L Yanthan
    Environmental Endocrinology Laboratory, Department of Zoology, North Eastern Hill University, Shillong 793022, India
    Indian J Exp Biol 45:676-82. 2007
    ..These findings seem to suggest that gonadal hormones and corticosteroid hormones have direct inhibitory influence on AA-NAT activity and, hence melatonin synthesis in the photoreceptive pineal organ of C. gariepinus...
  76. ncbi L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors
    J B Zawilska
    Department of Biogenic Amines, Polish Academy of Sciences, Lodz, Poland
    J Neural Transm 110:219-27. 2003
    ..Altogether these results indicate that in chicks L-745,870, the potent putative D(4)-DA receptor antagonist, behaves in vivo as a partial D(4) agonist...
  77. ncbi Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland
    Ann Humphries
    School of Biosciences, Cardiff University, Cardiff, UK
    Mol Cell Endocrinol 270:43-9. 2007
    ..A similar role of the Aanat E-box has been reported in zebrafish, indicating that Aanat E-box mediated silencing is a conserved feature of vertebrate biology...
  78. ncbi Circadian rhythms of melatonin-synthesizing enzyme activities and melatonin levels in planarians
    M T Itoh
    Department of Chemistry, St Marianna University School of Medicine, Sugao, Miyamae ku, Kawasaki 216 8511, Japan
    Brain Res 830:165-73. 1999
    ..Thus, it is strongly suggested that the planarian contains a circadian clock controlling melatonin synthesis...
  79. ncbi Differential somatostatin receptor subtype expression in human normal pineal gland and pineal parenchymal tumors
    J Champier
    INSERM U433, Faculté de médecine RTH Laennec, Lyon Cedex, France
    Cell Mol Neurobiol 23:101-13. 2003
    ..These results demonstrate the presence of somatostatin receptors in the human pineal gland, as described in other species, and point to a differential expression of the sst2 and sst5 subtypes associated with carcinogenesis...
  80. ncbi Expression and role of phosphodiesterase 6 in the chicken pineal gland
    F Morin
    Laboratoire de Neurobiologie Cellulaire, UMR CNRS 6558, UFR Sciences, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    J Neurochem 78:88-99. 2001
    ..Together, the data indicate that rod and cone forms of PDE6 are expressed in chick pineal cells and that this enzyme plays a role in the inhibition of melatonin synthesis by light...
  81. doi Pineal melatonin synthesis is altered in Period1 deficient mice
    E Christ
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Neuroscience 171:398-406. 2010
    ..This suggests that a deficient in Period1 elicits similar effects as the activation of the cAMP-signal transduction pathway in wildtype mice...
  82. pmc Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2
    M Smith
    School of Bioscience, Cardiff University, Cardiff, United Kingdom
    Mol Cell Biol 21:3704-13. 2001
    ..Analysis of 1,190 genes in the NATDNF2 pineal gland, including the AANAT gene, identified two whose expression is strongly linked to fra-2 expression: the genes encoding type II iodothyronine deiodinase and nectadrin (CD24)...
  83. ncbi In vivo observation of a non-noradrenergic regulation of arylalkylamine N-acetyltransferase gene expression in the rat pineal complex
    M L Garidou
    Neurobiologie des Rythmes, UMR CNRS 7518, Universite Louis Pasteur, 12 rue de l Université, F 67000, Strasbourg, France
    Neuroscience 105:721-9. 2001
    ....
  84. ncbi Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland
    S Takekida
    Department of Anatomy and Brain Science, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Neurosci 12:4557-61. 2000
    ....
  85. ncbi Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina
    M Bernard
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 68:213-24. 1997
    ..In contrast, changes in mRNA content are not involved in the rapid light-induced decrease in AA-NAT activity...
  86. pmc Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    J K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Mol Psychiatry 15:938-53. 2010
    ..Considering N-acetylserotonin as a potent antioxidant, such increases in N-acetylserotonin might be a compensatory response to increased oxidative stress, implicated in the pathogenesis of schizophrenia...
  87. ncbi Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction
    N W Chong
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:32991-8. 2000
    ..These observations suggest that binding of clock gene heterodimers to the cAANAT E box is a critical element in the expression of the cAANAT gene in vitro...
  88. ncbi The effects of near-ultraviolet light on serotonin N-acetyltransferase activity in the chick pineal gland
    J B Zawilska
    Department of Biogenic Amines, Polish Academy of Sciences, Lodz
    J Pineal Res 26:122-7. 1999
    ..It is concluded that UV-A irradiation, similar to visible light, potently suppresses melatonin biosynthesis in the chick pineal gland, with an alpha2-noradrenergic signal playing the role of an intermediate in this action...
  89. ncbi Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland
    Mathieu Chansard
    Department of Anatomy and Neurobiology, Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Drive, SW, Atlanta, GA 30310 1495, USA
    Brain Res Mol Brain Res 139:333-40. 2005
    ..Taken together, our data suggest that cAMP-induced Aa-Nat and Period1 are likely to be mediated by activation of JNK, whereas MKP-1 may be mediated by both p38(MAPK) and JNK activations...
  90. pmc Mutation screening of melatonin-related genes in patients with autism spectrum disorders
    Lina Jonsson
    Institute of Neuroscience and Physiology, Department of Pharmacology, Gothenburg University, Sweden
    BMC Med Genomics 3:10. 2010
    ....
  91. ncbi Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase
    P Michael Iuvone
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    Invest Ophthalmol Vis Sci 43:564-72. 2002
    ..This led to examination of the role of proteasomal proteolysis in the regulation of retinal AA-NAT activity and protein levels...
  92. ncbi Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein
    M Zatz
    Section on Biochemical Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892 4068, USA
    J Neurochem 74:2315-21. 2000
    ..Our results indicate that light can rapidly regulate the abundance of a specific protein (AA-NAT) within a photoreceptive cell...
  93. ncbi Characterization and regulation of a CHO cell line stably expressing human serotonin N-acetyltransferase (EC 2.3.1.87)
    G Ferry
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Cell Mol Life Sci 59:1395-405. 2002
    ..This cell line was used to screen libraries of compounds in a living system and led to the discovery of several potent specific and non-toxic AANAT inhibitors...
  94. ncbi Melatonin synthesis in the greenfrog retina in culture: I. Modulation by the light/dark cycle, forskolin and inhibitors of protein synthesis
    A L Alonso-Gomez
    Dpto Biología Animal II, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Life Sci 66:675-85. 2000
    ..The eyecup culture system is highly sensitive to light and chemical factors, which makes it particularly suitable as a model for the neurochemical analysis of melatonin biosynthesis in the retina of Rana perezi...
  95. ncbi Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase
    Bo Hwa Choi
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea
    J Neurochem 90:442-54. 2004
    ..These results suggest that AANAT was phosphorylated at Thr29 by PKC activation through the alpha(1)-adrenergic receptor in rat pineal glands, and that its phosphorylation might contribute to the stability and the activity of AANAT...
  96. ncbi Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions
    C Fukuhara
    Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive, SW, GA 30310-1495, Atlanta, USA
    Neurosci Lett 286:167-70. 2000
    ..Per2 seem to be controlled by a different mechanism...
  97. ncbi Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina
    M Bernard
    Laboratoire de Neuroendocrinologie, UMR CNRS 6558, Poitiers, France
    Reprod Nutr Dev 39:325-34. 1999
    ....
  98. ncbi Restricted feeding restores rhythmicity in the pineal gland of arrhythmic suprachiasmatic-lesioned rats
    Celine A Feillet
    Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, Centre National de la Recherche Scientifique, University Louis Pasteur, Strasbourg, France
    Eur J Neurosci 28:2451-8. 2008
    ..Thus, the present study demonstrates that daily RF in SCN-lesioned rats provides, probably via sympathetic fibres, synchronizing stimuli strong enough to drive rhythmicity in the pineal gland...
  99. ncbi Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences
    T Deguchi
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
    J Biol Chem 263:7528-33. 1988
    ..The purified protein was subjected to digestion by lysylendopeptidase and separated by high performance liquid chromatography. Partial amino acid sequences of three peptides were determined by a gas-phase sequence analyzer...
  100. ncbi Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms
    J H Stehle
    Dr Senckenbergische Anatomie, Anatomisches Institut II, Johann Wolfgang Goethe Universitat Frankfurt, Germany
    J Biol Rhythms 16:312-25. 2001
    ....
  101. ncbi Prolonged treatment with glucocorticoid dexamethasone suppresses melatonin production by the chick pineal gland and retina
    Jolanta B Zawilska
    Department of Pharmacodynamics, Medical University of Lodz, Poland
    Pol J Pharmacol 54:61-6. 2002
    ..It is suggested that prolonged treatment of animals with dexamethasone reduces the amplitude of the rhythmic melatonin production, a phenomenon which may affect chronobiological processes being under control of this hormone...

Research Grants70

  1. Serotonin N Acetyltransferase Mechanism and Inhibition
    Philip Cole; Fiscal Year: 2001
    ....
  2. Serotonin N-acethyltransferase Regulation & Inhibition
    Philip Cole; Fiscal Year: 2005
    ..It is expected that these studies will lead to an increase in our understanding about the role of melatonin in health and disease and that newly designed inhibitors may serve as lead agents for the treatment of sleep and mood disorders. ..
  3. Serotonin N-acethyltransferase Regulation & Inhibition
    Philip Cole; Fiscal Year: 2006
    ..It is expected that these studies will lead to an increase in our understanding about the role of melatonin in health and disease and that newly designed inhibitors may serve as lead agents for the treatment of sleep and mood disorders. ..
  4. Serotonin N Acetyltransferase Mechanism and Inhibition
    Philip Cole; Fiscal Year: 2002
    ....
  5. Serotonin N Acetyltransferase Mechanism and Inhibition
    Philip Cole; Fiscal Year: 2003
    ....
  6. Serotonin N-acethyltransferase Regulation & Inhibition
    Philip Cole; Fiscal Year: 2007
    ..It is expected that these studies will lead to an increase in our understanding about the role of melatonin in health and disease and that newly designed inhibitors may serve as lead agents for the treatment of sleep and mood disorders. ..
  7. Serotonin N Acetyltransferase Mechanism and Inhibition
    Philip Cole; Fiscal Year: 2004
    ....
  8. METHOXYINDOLES IN RETINA--FUNCTION AND REGULATION
    P Iuvone; Fiscal Year: 2000
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  9. METHOXYINDOLES IN RETINA--FUNCTION AND REGULATION
    P Iuvone; Fiscal Year: 2002
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  10. METHOXYINDOLES IN RETINA--FUNCTION AND REGULATION
    P Iuvone; Fiscal Year: 1999
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  11. METHOXYINDOLES IN RETINA--FUNCTION AND REGULATION
    P Iuvone; Fiscal Year: 2000
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  12. METHOXYINDOLES IN RETINA--FUNCTION AND REGULATION
    P Iuvone; Fiscal Year: 2001
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  13. Methoxyindoles in Retina: Function and Regulation
    P Iuvone; Fiscal Year: 2003
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  14. Molecular Dissection of Melatonin Synthesis In Vivo
    Jimo Borjigin; Fiscal Year: 2001
    ....
  15. Molecular Dissection of Melatonin Synthesis In Vivo
    Jimo Borjigin; Fiscal Year: 2003
    ....
  16. Methoxyindoles in Retina: Function and Regulation
    P Iuvone; Fiscal Year: 2005
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  17. Molecular Dissection of Melatonin Synthesis In Vivo
    Jimo Borjigin; Fiscal Year: 2002
    ....
  18. Methoxyindoles in Retina: Function and Regulation
    P Iuvone; Fiscal Year: 2004
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  19. Methoxyindoles in Retina: Function and Regulation
    P Iuvone; Fiscal Year: 2006
    ..It is anticipated that characterization of these systems will contribute to the understanding of visual cell physiology and some of the pathological processes that underlie photoreceptor degeneration. ..
  20. DRUG ABUSE RESEARCH CENTER
    SOLOMON SNYDER; Fiscal Year: 1999
    ..In addition, he will conduct studies aimed at identifying a novel "brain-specific" factor that binds to the Egr DNA consensus sequence. ..
  21. DRUG ABUSE RESEARCH CENTER
    SOLOMON SNYDER; Fiscal Year: 2000
    ..In addition, he will conduct studies aimed at identifying a novel "brain-specific" factor that binds to the Egr DNA consensus sequence. ..
  22. DRUG ABUSE RESEARCH CENTER
    SOLOMON SNYDER; Fiscal Year: 2001
    ..In addition, he will conduct studies aimed at identifying a novel "brain-specific" factor that binds to the Egr DNA consensus sequence. ..
  23. DRUG ABUSE RESEARCH CENTER
    SOLOMON SNYDER; Fiscal Year: 1999
    ..In addition, he will conduct studies aimed at identifying a novel "brain-specific" factor that binds to the Egr DNA consensus sequence. ..
  24. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    RICHARD ZIGMOND; Fiscal Year: 1990
    ..As such, they will be relevant to our understanding of factors promoting and limiting the recovery of function after neural damage, such as that caused by stroke, trauma, and degenerative neurological disease...
  25. ENVIRONMENTAL INFLUENCES ON SYNAPTIC PHARMACOLOGY
    RICHARD ZIGMOND; Fiscal Year: 1990
    ....
  26. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2003
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  27. ENVIRONMENTAL INFLUENCES ON SYNAPTIC PHARMACOLOGY
    RICHARD ZIGMOND; Fiscal Year: 1992
    ....
  28. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2004
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  29. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2005
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  30. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2002
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  31. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2006
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  32. ACETYLTRANSFERASE INHIBITION AND SELECTIVITY
    Philip Cole; Fiscal Year: 2002
    ..Selective inhibitors of HAT enzymes may be useful in the treatment of cancer, HIV, and other diseases related to the dysregulation of gene expression. ..
  33. ACETYLTRANSFERASE INHIBITION AND SELECTIVITY
    Philip Cole; Fiscal Year: 2003
    ..Selective inhibitors of HAT enzymes may be useful in the treatment of cancer, HIV, and other diseases related to the dysregulation of gene expression. ..
  34. ACETYLTRANSFERASE INHIBITION AND SELECTIVITY
    Philip Cole; Fiscal Year: 2004
    ..Selective inhibitors of HAT enzymes may be useful in the treatment of cancer, HIV, and other diseases related to the dysregulation of gene expression. ..
  35. ACETYLTRANSFERASE INHIBITION AND SELECTIVITY
    Philip Cole; Fiscal Year: 2001
    ..Selective inhibitors of HAT enzymes may be useful in the treatment of cancer, HIV, and other diseases related to the dysregulation of gene expression. ..
  36. PINEAL GLAND EFFECTS ON GROWTH AND DEVELOPMENT
    Vernon Rowe; Fiscal Year: 1980
    ..We study choline acetyltransferase, tryosine hydroxylase, acetylcholinesterase, serotonin N-acetyltransferase, hydroxyindole O-methyltransferase, and indole metabolism. We study the developmental pharmacology of the pineal cell cultures...
  37. TOXIC & CARCINOGENIC POTENTIAL OF 60 HZ MAGNETIC FIELDS
    David McCormick; Fiscal Year: 1993
    ..The 104-week study includes complete necropsies and histopathologic evaluation at the end of the study...
  38. 5-HT N-acetyltransferase and Cocaine-Induced Behaviors
    Tolga Uz; Fiscal Year: 2002
    ..e., sensitization and reward. ..
  39. 5-HT N-acetyltransferase and Cocaine-Induced Behaviors
    Tolga Uz; Fiscal Year: 2003
    ..e., sensitization and reward. ..
  40. 5-HT N-acetyltransferase and Cocaine-Induced Behaviors
    Tolga Uz; Fiscal Year: 2004
    ..e., sensitization and reward. ..
  41. PLASTICITY OF MAMMALIAN CIRCADIAN AXIS
    Gianluca Tosini; Fiscal Year: 2003
    ..abstract_text> ..
  42. The role of cellular factors in the HIV-1 capsid assembly pathway
    JAISRI LINGAPPA; Fiscal Year: 2008
    ..Together these biochemical and ultrastructural approaches will give us an integrated view of how a variety of cellular factors act sequentially to promote targeting and assembly of HIV-1 Gag in human cells. ..
  43. The role of cellular factors in the HIV-1 capsid assembly pathway
    Jaisri R Lingappa; Fiscal Year: 2010
    ..Together these biochemical and ultrastructural approaches will give us an integrated view of how a variety of cellular factors act sequentially to promote targeting and assembly of HIV-1 Gag in human cells. ..
  44. Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cells
    JAISRI LINGAPPA; Fiscal Year: 2009
    ....
  45. Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cells
    JAISRI LINGAPPA; Fiscal Year: 2008
    ..abstract_text> ..
  46. The role of cellular factors in the HIV-1 capsid assembly pathway
    JAISRI LINGAPPA; Fiscal Year: 2009
    ..Together these biochemical and ultrastructural approaches will give us an integrated view of how a variety of cellular factors act sequentially to promote targeting and assembly of HIV-1 Gag in human cells. ..
  47. Cell-free VEE assembly system and alphavirus drug screen
    JAISRI LINGAPPA; Fiscal Year: 2006
    ..The cell-free VEE assembly system offer a safe and low cost approach to understanding the mechanism of VEE capsid formation and to screen for agents active against alphaviruses that have potential as bioterrorism agents. ..
  48. Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cells
    Jaisri R Lingappa; Fiscal Year: 2010
    ....
  49. Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cells
    Jaisri R Lingappa; Fiscal Year: 2010
    ....
  50. Role of a Host Protein in HIV Particle Formation
    JAISRI LINGAPPA; Fiscal Year: 2003
    ..The studies proposed here will define the role of this novel transacting factor in HIV disease, and lay the foundation for assays that could be used for anti-retroviral drug screening in the future. ..
  51. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2000
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  52. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  53. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  54. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
  55. Photic and circadian regulation of retinal melatonin.
    Gianluca Tosini; Fiscal Year: 2003
    ..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
  56. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2009
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  57. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2008
    ..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  58. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2002
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  59. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2007
    ..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  60. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 1999
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  61. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2001
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  62. Photic and circadian regulation of retinal melatonin.
    Gianluca Tosini; Fiscal Year: 2006
    ..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
  63. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2003
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..