gamma glutamyltransferase

Summary

Summary: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

Top Publications

  1. ncbi Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
  2. ncbi Transient elevation of hepatic enzymes in volunteers after intake of alcohol
    Min Yue
    Digestive Department, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 5:52-5. 2006
  3. ncbi Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice
    A Arun Sam Lal
    R C C Laboratories India Pvt Ltd, Genome Valley, Shameerpet, Hyderabad 500 078, India
    J Environ Biol 28:201-7. 2007
  4. ncbi Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults
    Elfriede Ruttmann
    Department of Medical Statistics, Informatics, and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Circulation 112:2130-7. 2005
  5. ncbi Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
  6. pmc Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Bacteriol 186:244-7. 2004
  7. ncbi Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetes Care 27:1427-32. 2004
  8. ncbi Association between serum gamma-glutamyltransferase and C-reactive protein
    Duk Hee Lee
    Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    Atherosclerosis 178:327-30. 2005
  9. ncbi Serum gamma-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population
    C Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Stenglinstr 2, D 86156 Augsburg, Germany
    Atherosclerosis 189:297-302. 2006
  10. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002

Research Grants

  1. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
  2. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
  3. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
  4. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
  5. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
  6. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
  7. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
  8. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1991
  9. GLUTATHIONE CONJUGATION--MEDIATOR OF ORGAN TOXICITY
    Serrine Lau; Fiscal Year: 1992
  10. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2005

Detail Information

Publications253 found, 100 shown here

  1. ncbi Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
    The primary role of cellular gamma glutamyltransferase (GGT) is to metabolize extracellular reduced glutathione (GSH), allowing for precursor amino acids to be assimilated and reutilized for intracellular GSH synthesis...
  2. ncbi Transient elevation of hepatic enzymes in volunteers after intake of alcohol
    Min Yue
    Digestive Department, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 5:52-5. 2006
    ..This study was designed to detect the changes of hepatic enzymes after alcohol intake and evaluate the corresponding damage to the human body...
  3. ncbi Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice
    A Arun Sam Lal
    R C C Laboratories India Pvt Ltd, Genome Valley, Shameerpet, Hyderabad 500 078, India
    J Environ Biol 28:201-7. 2007
    ..From the study it is also concluded that the herbal mixture is safer than Liv 52...
  4. ncbi Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults
    Elfriede Ruttmann
    Department of Medical Statistics, Informatics, and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Circulation 112:2130-7. 2005
    ..However, few studies to date with sufficient sample size and follow-up investigated the association of GGT with CVD mortality...
  5. ncbi Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
    ..To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase [GGT], and alkaline phosphatase) may predict diabetes...
  6. pmc Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Bacteriol 186:244-7. 2004
    ..These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental gamma-glutamyl-cysteinyl peptides...
  7. ncbi Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetes Care 27:1427-32. 2004
    ..To investigate the association between serum gamma-glutamyltransferase (GGT) and risk of metabolic syndrome and type 2 diabetes in Japanese male office workers...
  8. ncbi Association between serum gamma-glutamyltransferase and C-reactive protein
    Duk Hee Lee
    Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    Atherosclerosis 178:327-30. 2005
    A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress...
  9. ncbi Serum gamma-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population
    C Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Stenglinstr 2, D 86156 Augsburg, Germany
    Atherosclerosis 189:297-302. 2006
    ..To investigate whether serum gamma-glutamyltransferase (GGT) is an independent predictor for incident coronary events in initially healthy men from the general population...
  10. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002
    ..In conclusion, a combination of easily accessible variables accurately predicts the absence of significant fibrosis and might render liver biopsy unnecessary in more than one third of patients with chronic hepatitis C...
  11. ncbi Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
    Philippe Andre
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:2355-61. 2007
    ..Our aim was to study the association of GGT with the development of the metabolic syndrome (MetS)...
  12. ncbi gamma-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, 1Ga Dongin Dong, Jung Gu, Daegu, South Korea 700 422
    J Clin Endocrinol Metab 89:5410-4. 2004
    ..In conclusion, in women as well as men, serum GGT level within its normal range predicted type 2 diabetes and may modify the well-known association between body mass index and type 2 diabetes...
  13. ncbi Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?
    Ji Seun Lim
    Department of Preventive Medicine and Health Promotion Research Center, College of Medicine, Kyungpook National University, Daegu, Korea
    Free Radic Biol Med 37:1018-23. 2004
    ..These associations were similarly observed among most subgroups. In conclusion, the current and previous studies strongly suggest that serum GGT level within its normal range may be an early marker of oxidative stress...
  14. ncbi Gamma glutamyltransferase and long-term survival: is it just the liver?
    Lili Kazemi-Shirazi
    Institute of Medical and Chemical Laboratory Diagnostics, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Clin Chem 53:940-6. 2007
    Increased gamma glutamyltransferase (GGT) is associated with cardiovascular disease. To date, however, few studies with sufficient sample size and follow-up have investigated the association of GGT with all-cause mortality.
  15. pmc Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
    ..The aim of this study was to determine the diagnostic utility of non-invasive markers of fibrosis, validated in chronic viral hepatitis and alcoholic liver disease (FibroTest, FT), in patients with NAFLD...
  16. ncbi Prevalence of metabolic syndrome increases with the increase in blood levels of gamma glutamyltransferase and alanine aminotransferase in Japanese men and women
    Eiji Oda
    Tachikawa Medical Center, Nagaoka
    Intern Med 48:1343-50. 2009
    b>Gamma glutamyltransferase (GGT) or alanine aminotransferase (ALT) is reported to be an independent risk factor of diabetes and cardiovascular disease and proposed as a component of metabolic syndrome (MS)...
  17. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
    ..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
  18. pmc The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer
    D J F Brown
    St Columba s Hospice, Edinburgh, UK
    J Clin Pathol 60:705-8. 2007
    ..Little is known about the general biochemical disturbance associated with the systemic inflammatory response in cancer...
  19. ncbi Liver enzymes and risk of diabetes and cardiovascular disease: results of the Firenze Bagno a Ripoli (FIBAR) study
    Matteo Monami
    Geriatric Unit, Department of Critical Care and Surgery, University of Florence, Florence 50141, Italy
    Metabolism 57:387-92. 2008
    ..5-28.1]), but not diabetes. Elevated gamma-GT or AST is an independent predictor of CVD. An increase of gamma-GT levels above the reference range, or also in the upper reference range, is an independent predictor of incident diabetes...
  20. ncbi Metabolism of glutamine and glutathione via gamma-glutamyltranspeptidase and glutamate transport in Helicobacter pylori: possible significance in the pathophysiology of the organism
    Keigo Shibayama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Mol Microbiol 64:396-406. 2007
    ..pylori...
  21. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  22. ncbi Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Clin Chem 52:1825-7. 2006
  23. ncbi Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells
    Alessandro Corti
    Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy
    Mutat Res 669:112-21. 2009
    ..The findings reported indicate that GGT activity is able to promote iron-dependent DNA oxidative damage, thus potentially representing an important mechanism in initiation/progression of neoplastic transformation...
  24. ncbi ABCB11 gene mutations in Chinese children with progressive intrahepatic cholestasis and low gamma glutamyltransferase
    Li yan Liu
    The Center for Pediatric Liver Diseases, Children s Hospital of Fudan University, Shanghai, China
    Liver Int 30:809-15. 2010
    ..ABCB11 gene mutations causing PFIC2 have been reported in some population groups, but not in mainland Chinese...
  25. ncbi Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra
    R Heiene
    Department of Small Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    Res Vet Sci 70:129-37. 2001
    ..4 and 2.0 ml min(-1) kg(-1), respectively on day 1 post-operatively and at the follow-up visit 1-4 months later. High urinary enzyme values often reflected extensive lesions in renal proximal tubular cells and sometimes reduced GFR...
  26. ncbi The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults
    Yang Ho Kang
    Department of Internal Medicine, Pusan National University School of Medicine, 1 10 Ami dong, Seo Ku, Busan 602 739, Republic of Korea
    Diabetes Res Clin Pract 77:306-13. 2007
    ..Recently, serum gamma glutamyltransferase (GGT) has been proposed as a marker of oxidative stress and is associated with a marked increase in the ..
  27. ncbi Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients
    Robert P Myers
    Department of Hepatology and Gastroenterology, hôpital La Pitié Salpêtrière, Paris, France
    AIDS 17:721-5. 2003
    ..Our aim was to determine the operating characteristics of a non-invasive index of biochemical markers for the prediction of fibrosis in patients with HIV/HCV co-infection...
  28. ncbi Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background
    Sei ichiro Kojima
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, 259 1193, Isehara, Bohseidai, Japan
    J Gastroenterol 38:954-61. 2003
    ..The aim of this investigation was to elucidate the time-course of changes in the prevalence of fatty liver, and to analyze its clinical backgrounds over the previous 12-year period...
  29. ncbi Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome
    Jiko Yamada
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 189:198-205. 2006
    ..present study attempted to establish whether elevated serum levels of alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) are independent (of each other) markers of systemic inflammation and oxidative stress as assessed ..
  30. ncbi Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women
    Alexander M Strasak
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 123:1902-6. 2008
    ..006). Our study is the first to demonstrate in a large population-based cohort that high GGT levels significantly increased cancer risk in women...
  31. pmc Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis
    Abigail Fraser
    Departmentof Social Medicine, Medical Research Council Centre for Causal Analysis in Translational Epidemiology, University of Bristol, Bristol, UK
    Diabetes Care 32:741-50. 2009
    ..To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes...
  32. ncbi Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population
    Constance E Ruhl
    Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
    Gastroenterology 136:477-85.e11. 2009
    ..In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality...
  33. ncbi Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C
    Vincent Leroy
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 46:775-82. 2007
    ..The aim of this study was to compare the diagnostic performance of 6 scores (MP3, Fibrotest, Fibrometer, Hepascore, Forns' score and APRI)...
  34. ncbi High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  35. ncbi Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease
    S G Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea
    Eur J Endocrinol 152:225-31. 2005
    ..We aimed to investigate the relationship between nonalcoholic fatty liver disease (NAFLD), serum adiponectin concentration and brachial-ankle pulse wave velocity (baPWV) as a risk marker for atherosclerosis...
  36. ncbi Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay
    Claudia E Carrasco-Legleu
    Departamento de Biologia Celular, Centro de Investigación y de Estudios Avanzados del IPN Cinvestav, Mexico, Mexico
    Int J Cancer 108:488-92. 2004
    ..This phenomenon was independent of IkappaBalpha degradation...
  37. pmc Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice
    M W Lieberman
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 93:7923-6. 1996
    ..These findings demonstrate the importance of GGT and the gamma-glutamyl cycle in cysteine and GSH homeostasis...
  38. ncbi Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors
    Francoise Imbert-Bismut
    Service of Biochemistry, hôpital La Pitié Salpêtrière, Paris, France
    Clin Chem Lab Med 42:323-33. 2004
    ..075+/-0.004 and 0.068+/-0.004, respectively. The low intra-laboratory and intra-patient variability in Fibrotest and Actitest results confirm Fibrotest and Actitest reliability...
  39. ncbi Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial
    T Poynard
    Hepatogastroenterology Groupe Hospitalier Pitié Salpêtrière, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Viral Hepat 9:128-33. 2002
    ..32 +/- 0.03 at 72 weeks; P=0.05). No significant differences were observed for hyaluronic acid.Hence, this fibrosis index could be used as a surrogate marker of the antifibrotic effect of treatments in patients with chronic hepatitis C...
  40. ncbi Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease
    Burcu Balam Yavuz
    Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey
    Int Psychogeriatr 20:815-23. 2008
    b>Gamma glutamyltransferase (GGT) plays a role in cellular glutathione uptake, which is an important element of antioxidant mechanisms. An increase in serum GGT is thought to be an early and sensitive marker of oxidative stress...
  41. ncbi Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency
    Ertan Mayatepek
    Department of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    J Lipid Res 45:900-4. 2004
    ..GGT deficiency represents a new inborn error of cysteinyl LT synthesis and provides a unique model in which to study the pathobiological coherence of LT and glutathione metabolism...
  42. ncbi Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population
    C Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Augsburg, Germany
    J Intern Med 258:527-35. 2005
    ..To examine gender-specific associations between gamma-glutamyltransferase (GGT) and incident type 2 diabetes mellitus in a representative population-based sample in Germany...
  43. pmc Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress-related markers in the U.S. population: results from the third National Health and Nutrition Examination Survey
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Environ Health Perspect 114:350-4. 2006
    ....
  44. ncbi A novel apoptosis-inducing protein from Helicobacter pylori
    Keigo Shibayama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Mol Microbiol 47:443-51. 2003
    ..pylori-mediated apoptosis. Our findings provide new insights into H. pylori pathogenicity and reveal a novel aspect of the bacterial gamma-glutamyl transpeptidase function...
  45. ncbi Liver enzymes and incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 31:1138-43. 2008
    ..We sought to examine the association between plasma concentrations of liver enzymes gamma-glutamyltransferase (GGT) and alanine transaminase (ALT) and incident diabetes, prospectively...
  46. ncbi Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita Shi, Osaka, Japan
    J Intern Med 254:287-95. 2003
    ..To investigate the association between serum gamma-glutamyltransferase (GGT) and risk for development of diabetes...
  47. ncbi Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Jung Gu, Daegu, South Korea 700 422
    Eur Heart J 27:2170-6. 2006
    ..This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes...
  48. ncbi gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis
    Anke Grzam
    Heidelberg Institute of Plant Sciences, University of Heidelberg, Im Neuenheimer Feld 360, Heidelberg, Germany
    FEBS Lett 581:3131-8. 2007
    ..GGT4:green fluorescent protein fusions were used to demonstrate that GGT4 is localized in the lumen of the vacuole...
  49. ncbi Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Plant J 49:878-88. 2007
    ..This identifies GGT3 as catalyzing the obligate initial step in GSH conjugate metabolism, and suggests that it has an important role in protecting plants from some xenobiotic chemicals...
  50. pmc Escherichia coli K-12 can utilize an exogenous gamma-glutamyl peptide as an amino acid source, for which gamma-glutamyltranspeptidase is essential
    H Suzuki
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    J Bacteriol 175:6038-40. 1993
    ..3.2.2) is essential. We suggest that the gamma-glutamyl linkage of a gamma-glutamyl peptide is hydrolyzed by gamma-glutamyltranspeptidase located in the periplasmic space, and the released amino acid is taken up and utilized by E. coli...
  51. ncbi Reproductive defects in gamma-glutamyl transpeptidase-deficient mice
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 141:4270-7. 2000
    ..These results demonstrate that GGT itself is not necessary for reproductive function. However, GGT plays an important role in cysteine homeostasis within the mouse reproductive axis...
  52. pmc A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
    Plant Physiol 148:1603-13. 2008
    ..This discovery led us to propose a new pathway for GSH turnover in plants where GSH is converted to 5OP and then to Glu by the combined action of gamma-glutamyl cyclotransferase and 5-oxoprolinase in the cytoplasm...
  53. ncbi Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Plant J 49:865-77. 2007
    ..These observations suggest that GGT1 is important in preventing oxidative stress by metabolizing extracellular GSSG, while GGT2 might be important in transporting glutathione into developing seeds...
  54. ncbi A strong interaction between serum gamma-glutamyltransferase and obesity on the risk of prevalent type 2 diabetes: results from the Third National Health and Nutrition Examination Survey
    Ji Sun Lim
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, Korea
    Clin Chem 53:1092-8. 2007
    ..We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance...
  55. ncbi Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants?
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Free Radic Res 43:533-7. 2009
    ..As a marker of the amount of conjugated xenobiotics, recent epidemiological findings about serum GGT imply the possibility of harmful effects of various environmental pollutants at background levels currently regarded as safe...
  56. ncbi Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes
    Silvia Dominici
    Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy
    Biofactors 17:187-98. 2003
  57. ncbi Glutathione-degrading enzymes of microvillus membranes
    E M Kozak
    J Biol Chem 257:6322-7. 1982
    ..The inhibition of dipeptidase by thiols has been employed to probe the relative significance of dipeptidase and aminopeptidase M in the metabolism of glutathione and its derivatives at the membrane surface...
  58. ncbi Gamma-glutamyltransferase and diabetes--a 4 year follow-up study
    D H Lee
    Department of Preventive Medicine, College of Medicine, Kosin University, 34 Amnam dong, Suh gu, Pusan, Korea 602 702
    Diabetologia 46:359-64. 2003
    ..We did a prospective study with the hypothesis that serum GGT is a predictor of incident diabetes...
  59. ncbi Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
    ..To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP)...
  60. ncbi Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase
    Christian Schmees
    Department of Medicine II, Technical University of Munich, Munich, Germany
    Gastroenterology 132:1820-33. 2007
    ..We aimed to identify the factor responsible for suppression of T-cell response and characterize this inhibitory effect on a cellular and molecular level...
  61. pmc Localization of members of the gamma-glutamyl transpeptidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis
    Melinda N Martin
    Biotechnology Center for Agriculture and the Environment, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Plant Physiol 144:1715-32. 2007
    ..Protoplasting experiments indicated that both GGT1 and GGT2 are localized extracellularly but have different physical or chemical associations...
  62. ncbi Two Japanese brothers with hereditary gamma-glutamyl transpeptidase deficiency
    M Iida
    Laboratory, Saitama Cardiovascular and Respiratory Center, Saitama, Japan
    J Inherit Metab Dis 28:49-55. 2005
    ..Urine amino acid analysis on an automatic analyser showed a slightly increased excretion of cystine and a large peak in the citrulline position due, at least in part, to thio-compounds...
  63. ncbi Beta-lipoprotein- and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis
    Aldo Paolicchi
    Department of Experimental Pathology, Dip di Patologia Sperimentale and B M I E, University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    Atherosclerosis 186:80-5. 2006
    ..05) and healthy subjects with elevated serum GGT (p<0.01). In addition, a relative decrease of total serum GGT was observed in CAD subjects of older age as compared to younger ones (p<0.005)...
  64. pmc Gamma-glutamyltranspeptidase, but not YwrD, is important in utilization of extracellular blutathione as a sulfur source in Bacillus subtilis
    Hiromichi Minami
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    J Bacteriol 186:1213-4. 2004
    ..It was shown that gamma-glutamyltranspeptidase, but not YwrD, is important in utilizing glutathione as the sole sulfur source in Bacillus subtilis...
  65. ncbi Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C
    Robert P Myers
    Department of Hepato Gastroenterology, hôpital La Pitié Salpêtrière, Paris, France
    Am J Gastroenterol 97:2419-25. 2002
    ..The aims of this study were: 1) to compare an index of five biochemical markers with historical features; and 2) to determine the utility of combining these features with the five-marker index for the prediction of significant fibrosis...
  66. ncbi Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study
    Dharmendrakumar A Patel
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Metabolism 56:792-8. 2007
    ..Elevations in liver enzymes ALT and GGT, within "reference" range, persist over time and relate to clinically relevant adverse CV risk profile in young adults...
  67. ncbi Net glutathione secretion across primary cultured rabbit conjunctival epithelial cell layers
    Hovhannes J Gukasyan
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 43:1154-61. 2002
    ..The purpose of the present study was to define transport characteristics of GSH in primary cultured rabbit conjunctival epithelial cells (RCECs)...
  68. ncbi Prognostic value of serum gamma-glutamyl transferase activity after myocardial infarction
    M Emdin
    CNR Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Eur Heart J 22:1802-7. 2001
    ..CONCLUSION: gamma-GT is an independent cardiac risk factor in ischaemic patients with established coronary atherosclerosis and previous myocardial infarction...
  69. ncbi Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, Istanbul, Turkey
    Prev Med 43:136-9. 2006
    The role of serum gamma glutamyltransferase (GGT) activity as a cardiovascular risk marker was studied basically cross-sectionally...
  70. pmc gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization
    K J McGovern
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Infect Immun 69:4168-73. 2001
    ..All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization...
  71. ncbi Should liver function tests be included in definitions of metabolic syndrome? Evidence from the association between liver function tests, components of metabolic syndrome and prevalent cardiovascular disease
    M C Devers
    Department of Diabetes, Glasgow Royal Infirmary, Glasgow, UK
    Diabet Med 25:523-9. 2008
    ..This study aims to determine: (1) the association between the five ATP3 MS diagnostic components and different LFTs, and (2) the association between raised LFTs and prevalent cardiovascular disease (CVD)...
  72. ncbi Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines
    M R van der Harst
    Faculty of Veterinary Medicine, Department of Equine Sciences, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
    Vet Res Commun 29:247-61. 2005
    ..It could thus be concluded that even a conservative dose regimen of gentamicin did not result in significant renal toxicity in healthy ponies...
  73. ncbi Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Stroke 31:1851-5. 2000
    ....
  74. ncbi Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme
    M Enoiu
    Centre du Medicament, UPRES EA 3117, Faculty of Pharmacy, University Henri Poincare, Nancy Cedex, France
    Free Radic Biol Med 29:825-33. 2000
    ....
  75. ncbi Colorimetric coupled enzyme assay for gamma-glutamyltransferase activity using glutathione as substrate
    Antonella Del Corso
    Dipartimento di Biologia, Sezione di Biochimica, Universita di Pisa, Via S Zeno, 51, 56100 Pisa, Italy
    J Biochem Biophys Methods 67:123-30. 2006
    ..Since the use of GSH as substrate, the proposed method can be usefully adopted for enzymological studies on GGT-related enzymes, a class of enzymes which is still waiting to be characterized...
  76. ncbi Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    FEMS Microbiol Lett 234:27-35. 2004
    ..This cell localization might be unique for N. meningitidis compared to other GGTs...
  77. pmc Isolation from a healthy carrier and characterization of a Neisseria meningitidis strain that is deficient in gamma-Glutamyl aminopeptidase activity
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 40:3035-7. 2002
    ..meningitidis isolate which lacked the activity due to the insertional mutation of the ggt gene, suggesting that naturally occurring N. meningitidis isolates do not always possess GGT activity...
  78. ncbi Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Duk Hee Lee
    Department of Preventive Medicine, College of Medicine, Kosin University, Pusan, Korea 602 202
    Clin Chem 49:1358-66. 2003
    ..We performed a prospective study to examine whether serum GGT predicts diabetes and hypertension...
  79. ncbi Reliability of the detection of meningococcal gamma-glutamyl transpeptidase as an identification marker for Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 48:485-7. 2004
    ..meningitidis isolates besides NIID113. The isolation frequency (1.2%) of ggt mutants among human isolates strongly confirmed the 98.8% reliability of GGT activity as the identification marker for N. meningitidis...
  80. ncbi In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin in rats
    H P Behrsing
    SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Toxicol In Vitro 19:1079-88. 2005
    ..Hepatocellular injury was evident only at high dose exposures. This is believed to be the first use of an in vitro liver tissue model to accurately predict the differential and concentration-dependent toxicities of these compounds...
  81. pmc Macrophage activation syndrome in a child with systemic juvenile rheumatoid arthritis
    Mina Hur
    Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:695-8. 2005
    ..This is the third case of MAS associated with S-JRA in Koreans, and the first one, in which hemophagocytic macrophages were proven in bone marrow...
  82. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
    ....
  83. ncbi Toxicity, bioavailability and pharmacokinetics of a newly formulated colistin sulfate solution
    B Lin
    Division of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Vet Pharmacol Ther 28:349-54. 2005
    ..The high bioavailability and the long-lasting serum retention time indicated that the new solution is suitable for i.m. in piglets with a recommended dose of 2.5 mg/kg injected twice daily...
  84. ncbi Evaluation of renal enzymuria and cellular excretion as an marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats
    Denizar Alberto da Silva Melo
    Pontificia Universidade Catolica do Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil
    Clin Chim Acta 373:88-91. 2006
    ....
  85. ncbi Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats
    Lysandro Pinto Borges
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105 900, RS, Brazil
    Chem Biol Interact 171:15-25. 2008
    ..The proposed mechanisms by which (PhSe)(2) acts in this experimental protocol are its antioxidant properties and its capacity to form a complex with cadmium...
  86. ncbi Effects of barbiturate administration on hepatic and renal biochemical parameters in new zealand white rabbits
    Alfredo González Gil
    Departamento de Fisiologia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Contemp Top Lab Anim Sci 44:43-5. 2005
    ..Therefore, caution is required in interpreting data on plasma biochemical parameters from rabbits anesthetized with pentobarbitone or thiopentone...
  87. ncbi Healthy centenarian subjects: the effect of red wine consumption on liver function tests
    P Pinzani
    Department of Critical Care Medicine and Surgery, Gerontology and Geriatrics Unit, University of Florence, 50139 Florence, Italy
    J Endocrinol Invest 28:120-2. 2005
    ..We conclude that red wine consumption in centenarians had no negative effect on circulating liver enzyme activities...
  88. ncbi Serum alpha-glutathione S-transferase as a sensitive marker of hepatocellular damage in patients with cystic fibrosis
    K Sídlová
    First Department of Pediatrics, Faculty Hospital Motol, Prague, Czech Republic
    Physiol Res 52:361-5. 2003
    ..Serum GSTA seems to be a more sensitive marker than transaminases for the monitoring of hepatocellular integrity and as an early predictor of hepatic damage...
  89. ncbi Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii
    Amy C Brown
    Department of Complementary and Alternative Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Clin Toxicol (Phila) 45:549-56. 2007
    ..To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu)...
  90. ncbi [Association of abnormality of liver enzymes and metabolic syndrome in patients with nonalcoholic fatty liver disease]
    Meng Liu
    Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 87:253-5. 2007
    ..To investigate the changes of liver enzymes in the patients with nonalcoholic fatty liver disease (NAFLD) and to analyze the association between liver enzymes and metabolic syndrome (MS)...
  91. ncbi Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial
    Joyce McKenzie
    Department of Medicine, Glasgow Royal Infirmary University NHS Trust, Glasgow, Scotland, UK
    Clin Endocrinol (Oxf) 65:40-4. 2006
    ..g. nonalcoholic fatty liver disease (NAFLD)]. Recent data indicating that hormone replacement therapy (HRT) may lessen diabetes risk is intriguing but explanatory mechanisms are unclear...
  92. ncbi Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs
    Yesim Ozarda Ilcol
    Department of Biochemistry, Uludag University Medical School, The Central Clinical Chemistry Laboratory, 16059 Bursa, Turkey
    Shock 24:288-93. 2005
    ..02 mg/kg endotoxin. These data show that choline status is altered during endotoxemia and that choline administration diminishes endotoxin-induced tissue injury...
  93. ncbi Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin
    Shuihua Zhang
    School of Pharmacy, East China University of Science and Technology, Mailbox 268, Shanghai 200237, China
    J Nutr Biochem 17:485-91. 2006
    ..Consequently, all these results showed that puerarin could effectively reverse chemical-induced liver fibrosis in experimental rats, via the recovery of hepatic injury as well as the induction of apoptosis in activated HSC...
  94. ncbi ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago
    Karelia Montane-Jaime
    Department of Pharmacology, University of the West Indies, St Augustine, Trinidad and Tobago
    Alcohol 39:81-6. 2006
    ..These results suggest that ADH1C polymorphisms are associated with alcohol dependence and alcohol associated elevations of liver enzymes in a population with a low frequency of ADH1B2 alleles...
  95. ncbi Rhabdomyolysis and hepatotoxicity in a female body builder
    Duane E Bates
    Department of Pharmacy, Foothills Medical Center, Calgary, AB, Canada
    J Trauma 60:407-9; discussion 409. 2006
  96. ncbi A 13-week subchronic toxicity study of dietary administered morin in F344 rats
    Y M Cho
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 44:891-7. 2006
    ..0% females. Based on the above findings, the no-observed-adverse-effect level (NOAEL) for both sexes was estimated to be 0.625% (299 and 356 mg/kg b.w./day for males and females, respectively)...
  97. ncbi Association between antipsychotic-induced elevation of liver enzymes and weight gain: a prospective study
    Maria A Rettenbacher
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria
    J Clin Psychopharmacol 26:500-3. 2006
    ..We conclude that antipsychotic-induced elevation of liver enzymes is mostly transient and could be associated with weight gain...
  98. ncbi A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study
    Nuray Atasoy
    Department of Psychiatry, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 31:1255-60. 2007
    ..In this article we aimed to evaluate the effect of atypical antipsychotic drugs namely olanzapine, risperidone and quetiapine on the hepatic enzymes and serum bilirubin levels in psychiatric patients...
  99. ncbi Effect of deferiprone on liver iron overload and fibrosis in hepatitis-C-virus-infected thalassemia
    An Chyi Chen
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    Hemoglobin 30:209-14. 2006
    ....
  100. ncbi Protective effect of Indigofera aspalathoides against CCl4-induced hepatic damage in rats
    B Rajkapoor
    Department of Pharmacology, Vinayaka Mission s College of Pharmacy, Yercaud Road, Salem 636 008, Tamilnadu, India
    J Herb Pharmacother 6:49-54. 2006
    ..The histopathological changes of liver sample were compared with respective control. The extract showed remarkable hepatoprotective effect...
  101. ncbi Severe liver enzyme elevation due to single-dose ranitidine in a pregnant woman
    Bulent Kantarceken
    Turk J Gastroenterol 17:242-3. 2006

Research Grants62

  1. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    ..Aim 5 of this proposal is to refine the chromosomal locations and test candidate genes for three newly mapped loci that contribute to AHL in A/J mice (ahl9 on Chr 11) and NOD/ShiLtJ mice (ahl10 on Chr 1 and ahl11 on Chr 6). ..
  2. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..The long- term goal of the proposed research program is to reduce the burden of NAFLD and halt progression of NAFLD to NASH. ..
  3. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ....
  4. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    ..denticola to pathogenesis. In the long term, the results derived from these studies could lead to novel ideas for the development of innovative strategies to diminish tissue pathology in periodontal disease. ..
  5. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
    ..Identifying these pathways and other proteins that are similarly modified will provide novel targets for diagnosis and therapy. ..
  6. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
    ..6) to determine if and how nor-HN2 can enhance the bladder toxicity induced by these conjugates. The results of these studies may help devise new strategies to minimize the toxic effects of this drug. ..
  7. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
  8. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1991
    ..The results of these studies will enhance our knowledge of normal and neoplastic regulation and will serve to focus future studies on the molecular genetics of altered regulation in leukemic cells...
  9. GLUTATHIONE CONJUGATION--MEDIATOR OF ORGAN TOXICITY
    Serrine Lau; Fiscal Year: 1992
    ..We therefore also propose to investigate the relative cell specific cytotoxicity of o-quinol and p-quinol linked GSH conjugates...
  10. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2005
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  11. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2005
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  12. METABOLISM AS A FACTOR IN DRUG-INDUCED NEUROTOXICITY
    TERRENCE MONKS; Fiscal Year: 1999
    ....
  13. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2004
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  14. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2004
    ....
  15. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  16. HEPATOCARCINOGENESIS IN VITRO USING ACTIVATED FOS GENES
    Russell Lebovitz; Fiscal Year: 1993
    ....
  17. FATE OF TOXIC CHEMICALS IN HEPATOCYTE AND HEPATOMA CELLS
    Michael Meredith; Fiscal Year: 1992
    ..7) Investigate the regulation of Gamma-cystathionase activity in rat hepatocytes before and after GSH depletion. 8) Examine the thiol status of human hepatocytes and evaluate the importance of the mitochondrial GSH pool...
  18. PROGENITOR CELLS IN IN VITRO LIVER EXPLANT CULTURES
    Lopa Mishra; Fiscal Year: 2000
    ..A. Rashid (JHU). The study of such in vitro explant cultures not only promises to a better understanding of liver formation, but also may in the future be utilized for tissue engineered composites as form of liver restoration therapy. ..
  19. MOLECULAR CHARACTERIZATION OF BRAIN GSH TRANSPORTERS
    Ram Kannan; Fiscal Year: 1999
    ....
  20. VASCULAR ENDOTHELIUM FORM AND FUNCTION: EFFECTS OF GLIA
    LAWRENCE DEBAULT; Fiscal Year: 1990
    ..Of equal importance will be the development and testing of in vitro co-culture schemes that allow the study of differentiated endothelial cell functions that are often lost in pure cell culture...
  21. ORGAN SPECIFIC DRUGS: CARDIOVASCULAR AND RENAL EFFECTS
    Marian Orlowski; Fiscal Year: 1980
    ..Because of this organ-specific activity, systemic effects and untoward reactions do not occur. Exploratory studies are being carried out towards an extension of this principle to other pro-drugs...
  22. CHEMICAL TOXICITY AND VITAMIN E REGULATION
    Donald Reed; Fiscal Year: 2001
    ..s. high tissue vitamin E levels under pathologic conditions. ..
  23. OXIDATION CHEMISTRY OF INDOLES
    Glenn Dryhurst; Fiscal Year: 2002
    ....
  24. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..
  25. In vivo Transgenic Reporter for Hepatobiliary Toxicity
    Seth Kullman; Fiscal Year: 2005
    ..We envision that this model can be employed as both a rapid screen for optimization of the lead molecule series selection (i.e. acute toxicity studies) as well as for more long-term chronic evaluations. ..
  26. IMPROVING PHYSICIAN MANAGEMENT OF ALCOHOL DISORDERS
    DAVID BUCHSBAUM; Fiscal Year: 1992
    ....
  27. SEQUENTIAL ANALYSIS OF ORAL CARCINOGENESIS
    DENNIS SOLT; Fiscal Year: 1990
    ....
  28. Rapid in Vivo Assay for Oral Cancer Chemoprevention
    DENNIS SOLT; Fiscal Year: 2002
    ..abstract_text> ..
  29. Tissue and Tumor Specific Glycosylation of Proteins
    Matthew West; Fiscal Year: 2009
    ..Page 2 Number pages consecutively at the bottom throughout Form Page 2 ..
  30. FUNCTION OF GAMMA GLUTAMYL LEUKOTRIENASE
    GEETHA HABIB; Fiscal Year: 2005
    ..4. Testing of the hypothesis that LTD4 is the principal cysteinyl LT mediator of bronchial asthma. ..
  31. WHAT IS THE METABOLIC FUNCTION OF SELENOPROTEIN W?
    PHILIP WHANGER; Fiscal Year: 2003
    ..These animals will also be supplemented with selenium to determine the effects upon selenoprotein W and GPX1 and GPX4 induction. ..
  32. BIOLOGICAL MARKERS OF ALCOHOL CONSUMPTION AMONG WOMEN
    Linda La Grange; Fiscal Year: 1992
    ..As well, levels of GGTP, urinary dolichols, and CDT will be compared to the established norms for nondrinkers and the known range for heavy consumers of alcohol...
  33. SENSORS FOR DIAGNOSIS OF ALCOHOL-RELATED LIVER DAMAGE
    Paul Hale; Fiscal Year: 1993
    ..The optimized sensors could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs...
  34. GAMMA GLUTAMYL TRANSPEPTIDASE & LYMPHOCYTE ACTIVATION
    David Karp; Fiscal Year: 2002
    ..GGT also may be a potential target in future immunotherapy strategies. ..
  35. AS-GSH CONJUGATION LIMITS AS AVAILABILITY & TOXICITY
    Michael Lieberman; Fiscal Year: 2004
    ....
  36. REGENERATION AND INTERACTIONS OF BRAIN ENDOTHELIUM
    PASQUALE CANCILLA; Fiscal Year: 1990
    ..By gaining an understanding of the molecules that regulate the formation of the "blood brain barrier", we can potentially regulate this process to more rapidly restore barrier function after injury...
  37. MOLECULAR ASPECTS OF THE ROLE OF ANDROGENS IN THE TESTIS
    BARBARA SANBORN; Fiscal Year: 1991
    ..These studies should increase our understanding of the hormonal control of Sertoli cell functions and provide new insight into aspects of the functions which may relate to the control of spermatogenesis...
  38. TRANSFORMATION OF HUMAN BREAST EPITHELIAL CELLS IN VITRO
    Satyabrata Nandi; Fiscal Year: 1993
    ..Our experience and approach suggest that development of a system(s) for transformation of human mammary epithelial cell in vitro is an achievable goal...
  39. Gabapentin as an Adjunct to Naltrexone for Alcoholism
    Raymond Anton; Fiscal Year: 2006
    ..This evaluation of a novel treatment will allow us to better understand combined pharmacotherapy and develop a new paradigm for medications development for alcoholism. ..
  40. Role of GH deficiency on mitochondrial bioenergetics
    Holly Brown Borg; Fiscal Year: 2005
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging, treat aging-related disorders and extend life span in humans. ..
  41. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  42. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  43. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..denticola to produce H2S from glutathione. The outcomes will elucidate the mechanisms of action that each member of the enzyme pathway plays in the virulence capacity of T. denticola. ..
  44. NALTREXONE & SSRI THERAPY FOR ALCOHOL DEPENDENCE
    STEPHANIE O MALLEY; Fiscal Year: 2004
    ..abstract_text> ..
  45. GENETICS OF COCAINE DEPENDENCE
    HENRY RICHARD KRANZLER; Fiscal Year: 2010
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
  46. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2008
    ..Completion of our studies will generate new knowledge in liver repopulation and cell and gene therapy mechanisms. This will lead to more effective liver-directed cell and gene therapy in people. ..
  47. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2008
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..
  48. Planning for a CTSA Application at the University of Connecticut
    Judith Fifield; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  49. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2007
    ..abstract_text> ..
  50. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2007
    ..Our studies will provide valuable preclinical information for eventual applications of cell therapy in people. ..
  51. Adoption of Pharmacotherapy in Alcoholism Treatment
    Peter Miller; Fiscal Year: 2005
    ..abstract_text> ..
  52. Glutathione deficiency & immune dysfunction during aging
    Rui Ming Liu; Fiscal Year: 2006
    ....
  53. Facilitating Alcohol Screening of Hypertensive Patients
    Peter Miller; Fiscal Year: 2006
    ..Such screening and intervention should improve blood pressure control in many of these patients and, in turn, reduce risk of chronic disease and death. ..
  54. Effectiveness and Costs of Enhanced Cocaine Treatments
    James McKay; Fiscal Year: 2005
    ..voucher reinforcement. Additional analyses will identify predictors of response to the TAU+V and TAU+S conditions, and test predictions regarding possible mechanisms of action. ..
  55. Effectiveness of extended treatments for drug dependence
    James R McKay; Fiscal Year: 2010
    ..Other analyses will test mediation hypotheses, examine potential moderator effects, and test the impact of disease management on HIV risk behaviors. ..
  56. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..Experiments detailed in the Preliminary Data and Experimental sections of this grant application directly address this deficiency in our knowledge. ..
  57. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2008
    ..abstract_text> ..
  58. AFTERCARE FOR COCAINE PATIENTS--EFFECTIVENESS AND COSTS
    James McKay; Fiscal Year: 2001
    ..However, it is expected that MIN aftercare will be cost-effective for low problem severity ("good prognosis") patients, whereas IND aftercare will be cost-effective for high problem severity ("poor prognosis") patients. ..