gamma glutamyltransferase

Summary

Summary: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

Top Publications

  1. ncbi Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
  2. ncbi Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome
    Jiko Yamada
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 189:198-205. 2006
  3. ncbi Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
  4. ncbi Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
    Philippe Andre
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:2355-61. 2007
  5. ncbi Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background
    Sei ichiro Kojima
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, 259 1193, Isehara, Bohseidai, Japan
    J Gastroenterol 38:954-61. 2003
  6. ncbi Gamma glutamyltransferase and long-term survival: is it just the liver?
    Lili Kazemi-Shirazi
    Institute of Medical and Chemical Laboratory Diagnostics, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Clin Chem 53:940-6. 2007
  7. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
  8. ncbi Prevalence of metabolic syndrome increases with the increase in blood levels of gamma glutamyltransferase and alanine aminotransferase in Japanese men and women
    Eiji Oda
    Tachikawa Medical Center, Nagaoka
    Intern Med 48:1343-50. 2009
  9. ncbi Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women
    Alexander M Strasak
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 123:1902-6. 2008
  10. doi Liver enzymes and risk of diabetes and cardiovascular disease: results of the Firenze Bagno a Ripoli (FIBAR) study
    Matteo Monami
    Geriatric Unit, Department of Critical Care and Surgery, University of Florence, Florence 50141, Italy
    Metabolism 57:387-92. 2008

Detail Information

Publications252 found, 100 shown here

  1. ncbi Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
    The primary role of cellular gamma glutamyltransferase (GGT) is to metabolize extracellular reduced glutathione (GSH), allowing for precursor amino acids to be assimilated and reutilized for intracellular GSH synthesis...
  2. ncbi Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome
    Jiko Yamada
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 189:198-205. 2006
    ..present study attempted to establish whether elevated serum levels of alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) are independent (of each other) markers of systemic inflammation and oxidative stress as assessed ..
  3. ncbi Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
    ..To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase [GGT], and alkaline phosphatase) may predict diabetes...
  4. ncbi Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
    Philippe Andre
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:2355-61. 2007
    ..Our aim was to study the association of GGT with the development of the metabolic syndrome (MetS)...
  5. ncbi Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background
    Sei ichiro Kojima
    Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine, 259 1193, Isehara, Bohseidai, Japan
    J Gastroenterol 38:954-61. 2003
    ..The aim of this investigation was to elucidate the time-course of changes in the prevalence of fatty liver, and to analyze its clinical backgrounds over the previous 12-year period...
  6. ncbi Gamma glutamyltransferase and long-term survival: is it just the liver?
    Lili Kazemi-Shirazi
    Institute of Medical and Chemical Laboratory Diagnostics, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Clin Chem 53:940-6. 2007
    Increased gamma glutamyltransferase (GGT) is associated with cardiovascular disease. To date, however, few studies with sufficient sample size and follow-up have investigated the association of GGT with all-cause mortality.
  7. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
    ..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
  8. ncbi Prevalence of metabolic syndrome increases with the increase in blood levels of gamma glutamyltransferase and alanine aminotransferase in Japanese men and women
    Eiji Oda
    Tachikawa Medical Center, Nagaoka
    Intern Med 48:1343-50. 2009
    b>Gamma glutamyltransferase (GGT) or alanine aminotransferase (ALT) is reported to be an independent risk factor of diabetes and cardiovascular disease and proposed as a component of metabolic syndrome (MS)...
  9. ncbi Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women
    Alexander M Strasak
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 123:1902-6. 2008
    ..006). Our study is the first to demonstrate in a large population-based cohort that high GGT levels significantly increased cancer risk in women...
  10. doi Liver enzymes and risk of diabetes and cardiovascular disease: results of the Firenze Bagno a Ripoli (FIBAR) study
    Matteo Monami
    Geriatric Unit, Department of Critical Care and Surgery, University of Florence, Florence 50141, Italy
    Metabolism 57:387-92. 2008
    ..5-28.1]), but not diabetes. Elevated gamma-GT or AST is an independent predictor of CVD. An increase of gamma-GT levels above the reference range, or also in the upper reference range, is an independent predictor of incident diabetes...
  11. ncbi Metabolism of glutamine and glutathione via gamma-glutamyltranspeptidase and glutamate transport in Helicobacter pylori: possible significance in the pathophysiology of the organism
    Keigo Shibayama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Mol Microbiol 64:396-406. 2007
    ..pylori...
  12. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002
    ..In conclusion, a combination of easily accessible variables accurately predicts the absence of significant fibrosis and might render liver biopsy unnecessary in more than one third of patients with chronic hepatitis C...
  13. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  14. pmc The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer
    D J F Brown
    St Columba s Hospice, Edinburgh, UK
    J Clin Pathol 60:705-8. 2007
    ..Little is known about the general biochemical disturbance associated with the systemic inflammatory response in cancer...
  15. ncbi Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra
    R Heiene
    Department of Small Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    Res Vet Sci 70:129-37. 2001
    ..4 and 2.0 ml min(-1) kg(-1), respectively on day 1 post-operatively and at the follow-up visit 1-4 months later. High urinary enzyme values often reflected extensive lesions in renal proximal tubular cells and sometimes reduced GFR...
  16. pmc Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Bacteriol 186:244-7. 2004
    ..These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental gamma-glutamyl-cysteinyl peptides...
  17. ncbi Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients
    Robert P Myers
    Department of Hepatology and Gastroenterology, hôpital La Pitié Salpêtrière, Paris, France
    AIDS 17:721-5. 2003
    ..Our aim was to determine the operating characteristics of a non-invasive index of biochemical markers for the prediction of fibrosis in patients with HIV/HCV co-infection...
  18. ncbi The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults
    Yang Ho Kang
    Department of Internal Medicine, Pusan National University School of Medicine, 1 10 Ami dong, Seo Ku, Busan 602 739, Republic of Korea
    Diabetes Res Clin Pract 77:306-13. 2007
    ..Recently, serum gamma glutamyltransferase (GGT) has been proposed as a marker of oxidative stress and is associated with a marked increase in the ..
  19. ncbi Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?
    Ji Seun Lim
    Department of Preventive Medicine and Health Promotion Research Center, College of Medicine, Kyungpook National University, Daegu, Korea
    Free Radic Biol Med 37:1018-23. 2004
    ..These associations were similarly observed among most subgroups. In conclusion, the current and previous studies strongly suggest that serum GGT level within its normal range may be an early marker of oxidative stress...
  20. ncbi Association between serum gamma-glutamyltransferase and C-reactive protein
    Duk Hee Lee
    Department of Preventive Medicine, Division of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu 700 422, Korea
    Atherosclerosis 178:327-30. 2005
    A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress...
  21. ncbi gamma-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, 1Ga Dongin Dong, Jung Gu, Daegu, South Korea 700 422
    J Clin Endocrinol Metab 89:5410-4. 2004
    ..In conclusion, in women as well as men, serum GGT level within its normal range predicted type 2 diabetes and may modify the well-known association between body mass index and type 2 diabetes...
  22. ncbi Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease
    S G Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea
    Eur J Endocrinol 152:225-31. 2005
    ..We aimed to investigate the relationship between nonalcoholic fatty liver disease (NAFLD), serum adiponectin concentration and brachial-ankle pulse wave velocity (baPWV) as a risk marker for atherosclerosis...
  23. pmc Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis
    Abigail Fraser
    Departmentof Social Medicine, Medical Research Council Centre for Causal Analysis in Translational Epidemiology, University of Bristol, Bristol, UK
    Diabetes Care 32:741-50. 2009
    ..To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes...
  24. doi Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population
    Constance E Ruhl
    Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
    Gastroenterology 136:477-85.e11. 2009
    ..In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality...
  25. pmc Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    Vlad Ratziu
    Hepato Gastroenterology, AP HP Groupe Hospitalier Pitié Salpétrière, Paris, France
    BMC Gastroenterol 6:6. 2006
    ..The aim of this study was to determine the diagnostic utility of non-invasive markers of fibrosis, validated in chronic viral hepatitis and alcoholic liver disease (FibroTest, FT), in patients with NAFLD...
  26. ncbi High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  27. ncbi Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C
    Vincent Leroy
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 46:775-82. 2007
    ..The aim of this study was to compare the diagnostic performance of 6 scores (MP3, Fibrotest, Fibrometer, Hepascore, Forns' score and APRI)...
  28. ncbi Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrian adults
    Elfriede Ruttmann
    Department of Medical Statistics, Informatics, and Health Economics, Innsbruck Medical University, Innsbruck, Austria
    Circulation 112:2130-7. 2005
    ..However, few studies to date with sufficient sample size and follow-up investigated the association of GGT with CVD mortality...
  29. pmc Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice
    M W Lieberman
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 93:7923-6. 1996
    ..These findings demonstrate the importance of GGT and the gamma-glutamyl cycle in cysteine and GSH homeostasis...
  30. ncbi Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population
    C Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Augsburg, Germany
    J Intern Med 258:527-35. 2005
    ..To examine gender-specific associations between gamma-glutamyltransferase (GGT) and incident type 2 diabetes mellitus in a representative population-based sample in Germany...
  31. ncbi Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors
    Francoise Imbert-Bismut
    Service of Biochemistry, hôpital La Pitié Salpêtrière, Paris, France
    Clin Chem Lab Med 42:323-33. 2004
    ..075+/-0.004 and 0.068+/-0.004, respectively. The low intra-laboratory and intra-patient variability in Fibrotest and Actitest results confirm Fibrotest and Actitest reliability...
  32. ncbi Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Plant J 49:865-77. 2007
    ..These observations suggest that GGT1 is important in preventing oxidative stress by metabolizing extracellular GSSG, while GGT2 might be important in transporting glutathione into developing seeds...
  33. ncbi Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial
    T Poynard
    Hepatogastroenterology Groupe Hospitalier Pitié Salpêtrière, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Viral Hepat 9:128-33. 2002
    ..32 +/- 0.03 at 72 weeks; P=0.05). No significant differences were observed for hyaluronic acid.Hence, this fibrosis index could be used as a surrogate marker of the antifibrotic effect of treatments in patients with chronic hepatitis C...
  34. ncbi Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency
    Ertan Mayatepek
    Department of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    J Lipid Res 45:900-4. 2004
    ..GGT deficiency represents a new inborn error of cysteinyl LT synthesis and provides a unique model in which to study the pathobiological coherence of LT and glutathione metabolism...
  35. pmc Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress-related markers in the U.S. population: results from the third National Health and Nutrition Examination Survey
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Environ Health Perspect 114:350-4. 2006
    ....
  36. doi Liver enzymes and incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 31:1138-43. 2008
    ..We sought to examine the association between plasma concentrations of liver enzymes gamma-glutamyltransferase (GGT) and alanine transaminase (ALT) and incident diabetes, prospectively...
  37. ncbi Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita Shi, Osaka, Japan
    J Intern Med 254:287-95. 2003
    ..To investigate the association between serum gamma-glutamyltransferase (GGT) and risk for development of diabetes...
  38. pmc A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
    Plant Physiol 148:1603-13. 2008
    ..This discovery led us to propose a new pathway for GSH turnover in plants where GSH is converted to 5OP and then to Glu by the combined action of gamma-glutamyl cyclotransferase and 5-oxoprolinase in the cytoplasm...
  39. ncbi A novel apoptosis-inducing protein from Helicobacter pylori
    Keigo Shibayama
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Mol Microbiol 47:443-51. 2003
    ..pylori-mediated apoptosis. Our findings provide new insights into H. pylori pathogenicity and reveal a novel aspect of the bacterial gamma-glutamyl transpeptidase function...
  40. ncbi Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Jung Gu, Daegu, South Korea 700 422
    Eur Heart J 27:2170-6. 2006
    ..This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes...
  41. ncbi Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis
    Naoko Ohkama-Ohtsu
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
    Plant J 49:878-88. 2007
    ..This identifies GGT3 as catalyzing the obligate initial step in GSH conjugate metabolism, and suggests that it has an important role in protecting plants from some xenobiotic chemicals...
  42. ncbi Reproductive defects in gamma-glutamyl transpeptidase-deficient mice
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 141:4270-7. 2000
    ..These results demonstrate that GGT itself is not necessary for reproductive function. However, GGT plays an important role in cysteine homeostasis within the mouse reproductive axis...
  43. doi Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease
    Burcu Balam Yavuz
    Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey
    Int Psychogeriatr 20:815-23. 2008
    b>Gamma glutamyltransferase (GGT) plays a role in cellular glutathione uptake, which is an important element of antioxidant mechanisms. An increase in serum GGT is thought to be an early and sensitive marker of oxidative stress...
  44. ncbi Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke
    P Jousilahti
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Stroke 31:1851-5. 2000
    ....
  45. pmc Escherichia coli K-12 can utilize an exogenous gamma-glutamyl peptide as an amino acid source, for which gamma-glutamyltranspeptidase is essential
    H Suzuki
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    J Bacteriol 175:6038-40. 1993
    ..3.2.2) is essential. We suggest that the gamma-glutamyl linkage of a gamma-glutamyl peptide is hydrolyzed by gamma-glutamyltranspeptidase located in the periplasmic space, and the released amino acid is taken up and utilized by E. coli...
  46. ncbi gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis
    Anke Grzam
    Heidelberg Institute of Plant Sciences, University of Heidelberg, Im Neuenheimer Feld 360, Heidelberg, Germany
    FEBS Lett 581:3131-8. 2007
    ..GGT4:green fluorescent protein fusions were used to demonstrate that GGT4 is localized in the lumen of the vacuole...
  47. ncbi Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes
    Silvia Dominici
    Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy
    Biofactors 17:187-98. 2003
  48. doi Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells
    Alessandro Corti
    Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy
    Mutat Res 669:112-21. 2009
    ..The findings reported indicate that GGT activity is able to promote iron-dependent DNA oxidative damage, thus potentially representing an important mechanism in initiation/progression of neoplastic transformation...
  49. doi Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants?
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Free Radic Res 43:533-7. 2009
    ..As a marker of the amount of conjugated xenobiotics, recent epidemiological findings about serum GGT imply the possibility of harmful effects of various environmental pollutants at background levels currently regarded as safe...
  50. ncbi A strong interaction between serum gamma-glutamyltransferase and obesity on the risk of prevalent type 2 diabetes: results from the Third National Health and Nutrition Examination Survey
    Ji Sun Lim
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, Korea
    Clin Chem 53:1092-8. 2007
    ..We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance...
  51. ncbi Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Clin Chem 52:1825-7. 2006
  52. ncbi Colorimetric coupled enzyme assay for gamma-glutamyltransferase activity using glutathione as substrate
    Antonella Del Corso
    Dipartimento di Biologia, Sezione di Biochimica, Universita di Pisa, Via S Zeno, 51, 56100 Pisa, Italy
    J Biochem Biophys Methods 67:123-30. 2006
    ..Since the use of GSH as substrate, the proposed method can be usefully adopted for enzymological studies on GGT-related enzymes, a class of enzymes which is still waiting to be characterized...
  53. ncbi Gamma-glutamyltransferase and diabetes--a 4 year follow-up study
    D H Lee
    Department of Preventive Medicine, College of Medicine, Kosin University, 34 Amnam dong, Suh gu, Pusan, Korea 602 702
    Diabetologia 46:359-64. 2003
    ..We did a prospective study with the hypothesis that serum GGT is a predictor of incident diabetes...
  54. ncbi Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, Istanbul, Turkey
    Prev Med 43:136-9. 2006
    The role of serum gamma glutamyltransferase (GGT) activity as a cardiovascular risk marker was studied basically cross-sectionally...
  55. ncbi Beta-lipoprotein- and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis
    Aldo Paolicchi
    Department of Experimental Pathology, Dip di Patologia Sperimentale and B M I E, University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    Atherosclerosis 186:80-5. 2006
    ..05) and healthy subjects with elevated serum GGT (p<0.01). In addition, a relative decrease of total serum GGT was observed in CAD subjects of older age as compared to younger ones (p<0.005)...
  56. pmc Gamma-glutamyltranspeptidase, but not YwrD, is important in utilization of extracellular blutathione as a sulfur source in Bacillus subtilis
    Hiromichi Minami
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    J Bacteriol 186:1213-4. 2004
    ..It was shown that gamma-glutamyltranspeptidase, but not YwrD, is important in utilizing glutathione as the sole sulfur source in Bacillus subtilis...
  57. ncbi Serum gamma-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population
    C Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Stenglinstr 2, D 86156 Augsburg, Germany
    Atherosclerosis 189:297-302. 2006
    ..To investigate whether serum gamma-glutamyltransferase (GGT) is an independent predictor for incident coronary events in initially healthy men from the general population...
  58. ncbi Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    FEMS Microbiol Lett 234:27-35. 2004
    ..This cell localization might be unique for N. meningitidis compared to other GGTs...
  59. ncbi Serum gamma-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetes Care 27:1427-32. 2004
    ..To investigate the association between serum gamma-glutamyltransferase (GGT) and risk of metabolic syndrome and type 2 diabetes in Japanese male office workers...
  60. ncbi Glutathione-degrading enzymes of microvillus membranes
    E M Kozak
    J Biol Chem 257:6322-7. 1982
    ..The inhibition of dipeptidase by thiols has been employed to probe the relative significance of dipeptidase and aminopeptidase M in the metabolism of glutathione and its derivatives at the membrane surface...
  61. ncbi Two Japanese brothers with hereditary gamma-glutamyl transpeptidase deficiency
    M Iida
    Laboratory, Saitama Cardiovascular and Respiratory Center, Saitama, Japan
    J Inherit Metab Dis 28:49-55. 2005
    ..Urine amino acid analysis on an automatic analyser showed a slightly increased excretion of cystine and a large peak in the citrulline position due, at least in part, to thio-compounds...
  62. ncbi Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines
    M R van der Harst
    Faculty of Veterinary Medicine, Department of Equine Sciences, Utrecht University, Yalelaan 12, 3584 CM Utrecht, The Netherlands
    Vet Res Commun 29:247-61. 2005
    ..It could thus be concluded that even a conservative dose regimen of gentamicin did not result in significant renal toxicity in healthy ponies...
  63. ncbi Should liver function tests be included in definitions of metabolic syndrome? Evidence from the association between liver function tests, components of metabolic syndrome and prevalent cardiovascular disease
    M C Devers
    Department of Diabetes, Glasgow Royal Infirmary, Glasgow, UK
    Diabet Med 25:523-9. 2008
    ..This study aims to determine: (1) the association between the five ATP3 MS diagnostic components and different LFTs, and (2) the association between raised LFTs and prevalent cardiovascular disease (CVD)...
  64. pmc Localization of members of the gamma-glutamyl transpeptidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis
    Melinda N Martin
    Biotechnology Center for Agriculture and the Environment, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Plant Physiol 144:1715-32. 2007
    ..Protoplasting experiments indicated that both GGT1 and GGT2 are localized extracellularly but have different physical or chemical associations...
  65. ncbi Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study
    Dharmendrakumar A Patel
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Metabolism 56:792-8. 2007
    ..Elevations in liver enzymes ALT and GGT, within "reference" range, persist over time and relate to clinically relevant adverse CV risk profile in young adults...
  66. ncbi Net glutathione secretion across primary cultured rabbit conjunctival epithelial cell layers
    Hovhannes J Gukasyan
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 43:1154-61. 2002
    ..The purpose of the present study was to define transport characteristics of GSH in primary cultured rabbit conjunctival epithelial cells (RCECs)...
  67. pmc gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization
    K J McGovern
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Infect Immun 69:4168-73. 2001
    ..All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization...
  68. ncbi Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
    ..To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP)...
  69. ncbi Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase
    Christian Schmees
    Department of Medicine II, Technical University of Munich, Munich, Germany
    Gastroenterology 132:1820-33. 2007
    ..We aimed to identify the factor responsible for suppression of T-cell response and characterize this inhibitory effect on a cellular and molecular level...
  70. ncbi Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C
    Robert P Myers
    Department of Hepato Gastroenterology, hôpital La Pitié Salpêtrière, Paris, France
    Am J Gastroenterol 97:2419-25. 2002
    ..The aims of this study were: 1) to compare an index of five biochemical markers with historical features; and 2) to determine the utility of combining these features with the five-marker index for the prediction of significant fibrosis...
  71. ncbi Prognostic value of serum gamma-glutamyl transferase activity after myocardial infarction
    M Emdin
    CNR Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Eur Heart J 22:1802-7. 2001
    ..CONCLUSION: gamma-GT is an independent cardiac risk factor in ischaemic patients with established coronary atherosclerosis and previous myocardial infarction...
  72. ncbi Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme
    M Enoiu
    Centre du Medicament, UPRES EA 3117, Faculty of Pharmacy, University Henri Poincare, Nancy Cedex, France
    Free Radic Biol Med 29:825-33. 2000
    ....
  73. ncbi Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay
    Claudia E Carrasco-Legleu
    Departamento de Biologia Celular, Centro de Investigación y de Estudios Avanzados del IPN Cinvestav, Mexico, Mexico
    Int J Cancer 108:488-92. 2004
    ..This phenomenon was independent of IkappaBalpha degradation...
  74. ncbi Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Duk Hee Lee
    Department of Preventive Medicine, College of Medicine, Kosin University, Pusan, Korea 602 202
    Clin Chem 49:1358-66. 2003
    ..We performed a prospective study to examine whether serum GGT predicts diabetes and hypertension...
  75. ncbi Reliability of the detection of meningococcal gamma-glutamyl transpeptidase as an identification marker for Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 48:485-7. 2004
    ..meningitidis isolates besides NIID113. The isolation frequency (1.2%) of ggt mutants among human isolates strongly confirmed the 98.8% reliability of GGT activity as the identification marker for N. meningitidis...
  76. pmc Isolation from a healthy carrier and characterization of a Neisseria meningitidis strain that is deficient in gamma-Glutamyl aminopeptidase activity
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 40:3035-7. 2002
    ..meningitidis isolate which lacked the activity due to the insertional mutation of the ggt gene, suggesting that naturally occurring N. meningitidis isolates do not always possess GGT activity...
  77. ncbi Evaluation of liver enzymes following elective laparoscopic cholecystectomy: are they really elevated?
    Amitai Bickel
    Department of Surgery, Western Galilee Hospital, P O Box 21, Nahariya, 22100, Israel
    J Gastrointest Surg 12:1418-21. 2008
    ..Studies made on a small number of patients have demonstrated significant modifications in liver function tests (LFT) following laparoscopic cholecystectomy...
  78. doi Changes of liver and muscle enzymes activity in patients with rigor
    Nikolaos Sevastos
    2nd Department of Internal Medicine, National University of Athens Medical School, Hippokration General Hospital, 114 Vas Sophias Ave, 11527 Athens, Greece
    Eur J Intern Med 19:109-14. 2008
    ..We investigated whether changes of liver and muscle enzymes activity are associated with rigor of several causes and have any prognostic significance...
  79. doi Serum liver enzyme activities in healthy Miniature Schnauzers with and without hypertriglyceridemia
    Panagiotis G Xenoulis
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    J Am Vet Med Assoc 232:63-7. 2008
    ..To determine whether hypertriglyceridemia in healthy Miniature Schnauzers is associated with high serum liver enzyme activities...
  80. ncbi Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system
    K Amin
    SRI International, Menlo Park, CA 94025, USA
    Toxicol Pathol 34:776-84. 2006
    ..In summary, additional experimentation using slice culture may further demonstrate its value in screening compounds that cause hepatobiliary toxicity...
  81. ncbi Effects of barbiturate administration on hepatic and renal biochemical parameters in new zealand white rabbits
    Alfredo González Gil
    Departamento de Fisiologia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Contemp Top Lab Anim Sci 44:43-5. 2005
    ..Therefore, caution is required in interpreting data on plasma biochemical parameters from rabbits anesthetized with pentobarbitone or thiopentone...
  82. doi Bimodal electric tissue ablation-long term studies of morbidity and pathological change
    Christopher Dobbins
    Division of Surgery, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia
    J Surg Res 148:251-9. 2008
    ..This may help to reduce the risk of local recurrence in these larger tumors. Prior to use in a clinical setting, a long term study was performed to assess associated morbidity and the pathological changes in the ablations...
  83. ncbi Toxicity, bioavailability and pharmacokinetics of a newly formulated colistin sulfate solution
    B Lin
    Division of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Vet Pharmacol Ther 28:349-54. 2005
    ..The high bioavailability and the long-lasting serum retention time indicated that the new solution is suitable for i.m. in piglets with a recommended dose of 2.5 mg/kg injected twice daily...
  84. ncbi Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis
    I Suda
    National Agricultural Research Center for Kyushu Okinawa Region, Kumamoto, Japan
    Eur J Clin Nutr 62:60-7. 2008
    ..To examine the effect of purple sweet potato (PSP) beverage rich in acylated anthocyanins on serum hepatic biomarkers in healthy Japanese men...
  85. ncbi Distribution of tissue enzymes in three species of pinnipeds
    Deborah A Fauquier
    The Marine Mammal Center, 1065 Fort Cronkhite, Marin Headlands, Sausalito, California 94965, USA
    J Zoo Wildl Med 39:1-5. 2008
    ..These results suggest that concurrent analysis of SDH, ALT, and CK would provide high specificity and sensitivity for the detection of hepatic lesions, and allow differentiation of liver from skeletal muscle lesions in pinniped species...
  86. ncbi In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin in rats
    H P Behrsing
    SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Toxicol In Vitro 19:1079-88. 2005
    ..Hepatocellular injury was evident only at high dose exposures. This is believed to be the first use of an in vitro liver tissue model to accurately predict the differential and concentration-dependent toxicities of these compounds...
  87. ncbi Brief communication: clinical implications of short-term variability in liver function test results
    Mariana Lazo
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 148:348-52. 2008
    ..Clinicians sometimes order liver tests as part of a screening examination or general work-up. Current guidelines do not recommend routine retesting of abnormal results in asymptomatic patients...
  88. pmc Macrophage activation syndrome in a child with systemic juvenile rheumatoid arthritis
    Mina Hur
    Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:695-8. 2005
    ..This is the third case of MAS associated with S-JRA in Koreans, and the first one, in which hemophagocytic macrophages were proven in bone marrow...
  89. ncbi Cholinesterase and other serum liver enzymes in underweight outpatients with eating disorders
    Concetta Montagnese
    Human Nutrition, Department of Food Science, Federico II University, Naples, Italy
    Int J Eat Disord 40:746-50. 2007
    ..The present study aimed to evaluate serum liver enzymes in underweight outpatients with anorexia nervosa (A-NERV) or eating disorders not otherwise specified (EDNOS)...
  90. ncbi Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs
    Yesim Ozarda Ilcol
    Department of Biochemistry, Uludag University Medical School, The Central Clinical Chemistry Laboratory, 16059 Bursa, Turkey
    Shock 24:288-93. 2005
    ..02 mg/kg endotoxin. These data show that choline status is altered during endotoxemia and that choline administration diminishes endotoxin-induced tissue injury...
  91. ncbi In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid
    Jongwon Choi
    College of Pharmacy, Kyungsung University, Busan, Korea
    J Med Food 8:348-52. 2005
    ..These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure...
  92. doi Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
    Ming Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 550 S Jackson St, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 325:409-16. 2008
    ..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis...
  93. ncbi Role of hepatic enzymes in the biochemical assessment of the severity of sickle cell anemia
    D P Oparinde
    Department of Chemical Pathology and Immunology, Ladoke Akintola University of Technology, College of Medicine, University of Ilorin, florin, Kwara State, Nigeria
    Trop Gastroenterol 27:118-21. 2006
    ....
  94. ncbi Risperidone and liver function tests in children and adolescents: a short-term prospective study
    Ayten Erdogan
    Department of Child and Adolescent Psychiatry, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 32:849-57. 2008
    ..The purpose of this prospective study is to document changes in the liver function tests (LFTs) associated with risperidone usage in a group of children and adolescents...
  95. ncbi Severe liver enzyme elevation due to single-dose ranitidine in a pregnant woman
    Bulent Kantarceken
    Turk J Gastroenterol 17:242-3. 2006
  96. ncbi An evaluation of the Swedish ignition interlock program
    Bo Bjerre
    Traffic Medicine Advisory Board, Swedish National Road Administration, Borlange, Sweden
    Traffic Inj Prev 4:98-104. 2003
    ..Nevertheless, the preliminary results are so promising that the program will now be expanded to cover all of Sweden as well as to include all driver's license categories...
  97. ncbi Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin
    Shuihua Zhang
    School of Pharmacy, East China University of Science and Technology, Mailbox 268, Shanghai 200237, China
    J Nutr Biochem 17:485-91. 2006
    ..Consequently, all these results showed that puerarin could effectively reverse chemical-induced liver fibrosis in experimental rats, via the recovery of hepatic injury as well as the induction of apoptosis in activated HSC...
  98. ncbi Clinical evaluation and hepatic laboratory assessment in individuals with congestive heart failure
    Luiz Antônio Brito Arruda Vasconcelos
    Universidade Estadual de Campinas, Campinas, SP, Brazil
    Arq Bras Cardiol 88:590-5. 2007
    ..To verify the clinical alterations and, in particular, hepatic laboratory alterations in patients in each of the heart failure (HF) functional classes...
  99. ncbi [Association of abnormality of liver enzymes and metabolic syndrome in patients with nonalcoholic fatty liver disease]
    Meng Liu
    Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 87:253-5. 2007
    ..To investigate the changes of liver enzymes in the patients with nonalcoholic fatty liver disease (NAFLD) and to analyze the association between liver enzymes and metabolic syndrome (MS)...
  100. ncbi Liver biochemistry profile, significance and endoscopic management of biliary tract complications post orthotopic liver transplantation
    Yogesh M Shastri
    Department of Medicine I, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    World J Gastroenterol 13:2819-25. 2007
    ..To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy...
  101. ncbi Steatosis and hepatic markers before and shortly after bariatric surgery
    M R A de Abreu
    Departamento de Analises Clinicas, Faculdade de Ciências Farmacêuticas de Araraquara UNESP SP Rua Expedicionários do Brasil n 1621, Araraquara SP 14801 902, Brazil
    Ann Clin Biochem 44:63-9. 2007
    ..We present new findings on liver steatosis detected in a group of 20 morbidly obese patients who were reassessed shortly after bariatric surgery (BS) by assaying hepatic markers in their serum...

Research Grants66

  1. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2000
    ..Neuropsychological tests, hair sampling, and measurement of amalgam release rates will be conducted at baseline and annually. A subject retention rate of 75% at the end of five-years is anticipated. ..
  2. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 1999
    ..Neuropsychological tests, hair sampling, and measurement of amalgam release rates will be conducted at baseline and annually. A subject retention rate of 75% at the end of five-years is anticipated. ..
  3. Associations between Non-8-Carbon-Chain Perfuoroalkyl Acids and Serum Lipid, Live
    Stephanie J Frisbee; Fiscal Year: 2010
    ..AST Aspartate aminotransferase BiliDirect Direct Bilirubin BiliTotal Total Bilirubin GGT Gamma glutamyltransferase LDH Lactate dehydrogenase BUN Blood urea nitrogen PUBLIC HEALTH RELEVANCE: NARRATIVE The primary ..
  4. LEUKOTRIENES AND THE BLOOD-BRAIN BARRIER
    Keith Black; Fiscal Year: 1993
    ..3) 5-lipoxygenase transcripts will be further characterized in human brain tumors. 4) Studies will determine whether permeability to drugs is increased in experimental tumors after intracarotid infusion of leukotrienes...
  5. EPIDIDYMAL GLUTATHIONE--PHYSIOLOGIC & MOLECULAR STUDIES
    BARRY HINTON; Fiscal Year: 1992
    ..The findings from this proposal will also provide fundamental information for the development of a male contraceptive and treatment of certain forms of male infertility...
  6. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
  7. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2003
    ..Mixed lymphocyte reactions will be performed in the presence of virally infected and uninfected human Sertoli cells, to determine their immunosuppressive ability. ..
  8. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1990
    ..The results of these studies will enhance our knowledge of normal and neoplastic regulation and will serve to focus future studies on the molecular genetics of altered regulation in leukemic cells...
  9. MECHANISM OF CYCLOPHOSPHAMIDE TOXICITY
    JAMES KEHRER; Fiscal Year: 1999
    ..6) to determine if and how nor-HN2 can enhance the bladder toxicity induced by these conjugates. The results of these studies may help devise new strategies to minimize the toxic effects of this drug. ..
  10. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    ..denticola to pathogenesis. In the long term, the results derived from these studies could lead to novel ideas for the development of innovative strategies to diminish tissue pathology in periodontal disease. ..
  11. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2009
    ..Identifying these pathways and other proteins that are similarly modified will provide novel targets for diagnosis and therapy. ..
  12. GLUTATHIONE CONJUGATION: MEDIATOR OF ORGAN TOXICITY
    Serrine Lau; Fiscal Year: 1990
    ..We therefore also propose to investigate the relative cell specific cytotoxicity of o-quinol and p-quinol linked GSH conjugates...
  13. GLUTATHIONE MODULATION OF ALKYLAYTORS IN MEDULLOBLASTOMA
    Henry Friedman; Fiscal Year: 1992
    ....
  14. GLUTATHIONE MODULATION OF ALKYLAYTORS IN MEDULLOBLASTOMA
    Henry Friedman; Fiscal Year: 1993
    ....
  15. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2003
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  16. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2005
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  17. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2001
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  18. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2002
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  19. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2005
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  20. GENE REGULATION OF EPIDIDYMAL GSH-METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 1999
    ..The finding from this proposal will provide fundamental information for the treatment of certain forms of male infertility. ..
  21. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2004
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  22. HEALTH EFFECTS OF DENTAL AMALGAMS IN CHILDREN
    Sonja McKinlay; Fiscal Year: 2003
    ..A non- orthogonal analysis of covariance will test for equivalence on IQ scores between treatments arms similar modeling will be used to address secondary aims. ..
  23. AMINO ACID AND PROTEIN METABOLISM
    ALTON MEISTER; Fiscal Year: 1992
    ..The evidence that has thus far been achieved indicates that further studies on the modulation of glutathione metabolism may be a promising pathway of research...
  24. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2006
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..
  25. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2005
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..
  26. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2004
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..
  27. SIGNIFICANCE OF GGT EXPRESSION IN TUMORS
    MARIE HANIGAN; Fiscal Year: 2007
    ..The goal of this research is to understand the molecular mechanisms by which cisplatin kills cells and the mechanism by which cells become resistant to cisplatin. ..
  28. Red Blood Cell S-nitrosothiols and Oxygenation
    JONATHAN STAMLER; Fiscal Year: 2009
    ....
  29. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2010
    ....
  30. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2001
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  31. BIOCHEMISTRY OF HYPERTHERMIC CELLULAR INACTIVATION
    Michael Freeman; Fiscal Year: 1992
    ..The purpose of this aim is to obtain information which can be applied toward understanding how glutathione depletion can increase thermal radiosensitivity...
  32. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2002
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  33. BIOCHEMISTRY OF HYPERTHERMIC CELLULAR INACTIVATION
    Michael Freeman; Fiscal Year: 1993
    ..The purpose of this aim is to obtain information which can be applied toward understanding how glutathione depletion can increase thermal radiosensitivity...
  34. The Role of Gelatinase A in Interstitial Fibrosis
    Sunfa Cheng; Fiscal Year: 2004
    ..Since the TGF- beta1 transgenic mouse develops fibrosis, this crossing will evaluate gelatinase A as distal effector for TGF- beta1- induced fibrosis. ..
  35. METABOLISM AS A FACTOR IN DRUG-INDUCED NEUROTOXICITY
    TERRENCE MONKS; Fiscal Year: 1999
    ....
  36. METABOLIC & DEVELOPMENTAL ASPECTS OF MENTAL RETARDATION
    H Zielke; Fiscal Year: 2006
    ..These studies may lead to the development of targeted neuroprotective interventions in neonates and children. ..
  37. METABOLIC & DEVELOPMENTAL ASPECTS OF MENTAL RETARDATION
    H Zielke; Fiscal Year: 2006
    ..These studies may lead to the development of targeted neuroprotective interventions in neonates and children. ..
  38. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2003
    ....
  39. METABOLIC & DEVELOPMENTAL ASPECTS OF MENTAL RETARDATION
    H Zielke; Fiscal Year: 2005
    ..These studies may lead to the development of targeted neuroprotective interventions in neonates and children. ..
  40. METABOLIC & DEVELOPMENTAL ASPECTS OF MENTAL RETARDATION
    H Zielke; Fiscal Year: 2007
    ..These studies may lead to the development of targeted neuroprotective interventions in neonates and children. ..
  41. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2000
    ....
  42. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2002
    ....
  43. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2001
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  44. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2003
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  45. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2000
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  46. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2004
    ....
  47. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2004
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  48. METABOLIC & DEVELOPMENTAL ASPECTS OF MENTAL RETARDATION
    H Zielke; Fiscal Year: 2004
    ..These studies may lead to the development of targeted neuroprotective interventions in neonates and children. ..
  49. BENZENE METABOLITES AND HEMATOTOXICITY
    TERRENCE MONKS; Fiscal Year: 2001
    ....
  50. GENE REGULATION OF EPIDIDYMAL GSH METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 2002
    ..The findings from this proposal will provide fundamental information for the treatment of certain forms of male infertility and the development of a male contraceptive. ..
  51. LEUKOTRIENES AND THE BLOOD-BRAIN BARRIER
    Keith Black; Fiscal Year: 1999
    ..5) Studies will determine whether permeability to drugs is increased in experimental tumors after intracarotid infusion of leukotrienes and other vasoactive compounds. ..
  52. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2002
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  53. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2003
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  54. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  55. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2001
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  56. S-NITROSOTHIOL BREAKDOWN BY AIRWAY EPITHELIAL CELLS
    Benjamin Gaston; Fiscal Year: 2006
    ..We anticipate that this project will provide new tools for understanding the cell biology of cystic fibrosis and asthma, and that it may lead to the development of new therapies for both diseases. ..
  57. S-NITROSOTHIOL BREAKDOWN BY AIRWAY EPITHELIAL CELLS
    Benjamin Gaston; Fiscal Year: 2003
    ..We anticipate that this project will provide new tools for understanding the cell biology of cystic fibrosis and asthma, and that it may lead to the development of new therapies for both diseases. ..