tyrosine 3 monooxygenase

Summary

Summary: An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.

Top Publications

  1. ncbi 14-3-3 proteins: structure, function, and regulation
    H Fu
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 40:617-47. 2000
  2. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
  3. ncbi Tyrosine hydroxylase phosphorylation: regulation and consequences
    Peter R Dunkley
    School of Biomedical Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 91:1025-43. 2004
  4. pmc TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
    F Kanai
    Division of Signal Transduction, Department of Medicine and Department of Surgery, Beth Israel Deaconess Medical Center, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 19:6778-91. 2000
  5. ncbi Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens
    Julie Bakker
    Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital 1, B36, 4000 Liege, Belgium
    Nat Neurosci 9:220-6. 2006
  6. ncbi The structural basis for 14-3-3:phosphopeptide binding specificity
    M B Yaffe
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cell 91:961-71. 1997
  7. ncbi Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish
    David L McLean
    Department of Neurobiology and Behavior, Life Sciences Building, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 480:38-56. 2004
  8. ncbi Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
  9. pmc Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons
    Danhui Zhang
    Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA
    J Neurosci 27:5349-62. 2007
  10. pmc Glutamatergic neurons are present in the rat ventral tegmental area
    Tsuyoshi Yamaguchi
    National Institute on Drug Abuse, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 25:106-18. 2007

Detail Information

Publications240 found, 100 shown here

  1. ncbi 14-3-3 proteins: structure, function, and regulation
    H Fu
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 40:617-47. 2000
    ..In this review, we examine the structural basis for 14-3-3-ligand interactions, proposed functions of 14-3-3 in various signaling pathways, and emerging views of mechanisms that regulate 14-3-3 actions...
  2. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  3. ncbi Tyrosine hydroxylase phosphorylation: regulation and consequences
    Peter R Dunkley
    School of Biomedical Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 91:1025-43. 2004
    ..Hierarchical phosphorylation depends on the state of the substrate providing a novel form of control of tyrosine hydroxylase activation...
  4. pmc TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
    F Kanai
    Division of Signal Transduction, Department of Medicine and Department of Surgery, Beth Israel Deaconess Medical Center, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 19:6778-91. 2000
    ..TAZ may link events at the plasma membrane and cytoskeleton to nuclear transcription in a manner that can be regulated by 14-3-3...
  5. ncbi Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens
    Julie Bakker
    Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital 1, B36, 4000 Liege, Belgium
    Nat Neurosci 9:220-6. 2006
    ..These results clearly demonstrate that prenatal estrogens masculinize and defeminize the brain and that AFP protects the female brain from these effects of estrogens...
  6. ncbi The structural basis for 14-3-3:phosphopeptide binding specificity
    M B Yaffe
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cell 91:961-71. 1997
    ..Finally, we show that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl...
  7. ncbi Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish
    David L McLean
    Department of Neurobiology and Behavior, Life Sciences Building, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 480:38-56. 2004
    ..Our results suggest that the major aminergic systems described in adults are in place shortly after hatching, at a time when zebrafish are accessible to a battery of techniques to test neuronal function during behavior...
  8. ncbi Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
    ..These data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients...
  9. pmc Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons
    Danhui Zhang
    Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA
    J Neurosci 27:5349-62. 2007
    ..Collectively, these results suggest that PKCdelta phosphorylates PP2Ac to enhance its activity and thereby reduces TH-ser40 phosphorylation and TH activity and ultimately dopamine synthesis...
  10. pmc Glutamatergic neurons are present in the rat ventral tegmental area
    Tsuyoshi Yamaguchi
    National Institute on Drug Abuse, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 25:106-18. 2007
    ..Based on the results described here, we concluded that the VTA contains glutamatergic neurons that in their vast majority are clearly non-DAergic and non-GABAergic...
  11. ncbi Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio)
    J Kaslin
    Department of Biology, Abo Akademi University, BioCity, FIN-20520 Turku/Abo, Finland
    J Comp Neurol 440:342-77. 2001
    ..The results also provide evidence of homologies to mammalian systems and allow identification of several previously uncharacterized systems in zebrafish mutants...
  12. pmc Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    James R Connor
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Brain 132:2403-12. 2009
    ..The results are consistent with the hypothesis that a primary iron insufficiency produces a dopaminergic abnormality characterized as an overly activated dopaminergic system as part of the RLS pathology...
  13. ncbi Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds
    M F Salvatore
    Department of Biochemistry and Molecular Biology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Neurochem 75:225-32. 2000
    ....
  14. ncbi Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
    Jin Xu
    Department of Neurology, Harvard Medical School and Division of Neuroscience, The Children s Hospital, Boston, Massachusetts, USA
    Nat Med 8:600-6. 2002
    ..Thus, accumulation of soluble alpha-synuclein protein complexes can render endogenous dopamine toxic, suggesting a potential mechanism for the selectivity of neuronal loss in PD...
  15. ncbi Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo
    Lilla M Farkas
    Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 23:5178-86. 2003
    ..Together, our results identify TGF-beta as an essential mediator for the induction and maintenance of midbrain dopaminergic neurons...
  16. ncbi Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Jennifer L Tillerson
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Exp Neurol 178:80-90. 2002
    ..Detection of dopamine-modulated behavioral changes in moderately depleted MPTP mice will allow for more efficacious use of this model in PD research...
  17. ncbi 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin
    Antje Gohla
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 12:1704-10. 2002
    ..Taken together, these results suggest that 14-3-3zeta proteins may play a dynamic role in the regulation of cellular actin structures through the maintenance of phosphocofilin levels...
  18. pmc Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell Biol 20:6904-12. 2000
    ..These results indicate that 14-3-3 proteins negatively regulate HDAC4 by preventing its nuclear localization and thereby uncover a novel regulatory mechanism for HDACs...
  19. ncbi 14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta
    Katarzyna Bialkowska
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:33342-50. 2003
    ..Thus, introduction of the 14-3-3 zeta binding domain of GP Ibalpha into target cells might provide a method for regulating integrin-induced pathways in a variety of pathological conditions...
  20. ncbi Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb
    Minoree Kohwi
    Department of Neurological Surgery, Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:6997-7003. 2005
    ..Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage...
  21. ncbi Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
    E Bezard
    Manchester Movement Disorder Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    J Neurosci 21:6853-61. 2001
    ....
  22. doi Induction of human mesenchymal stem cells into dopamine-producing cells with different differentiation protocols
    Ran Barzilay
    Laboratory of Neurosciences, Felsenstein Medical Research Center, Petah Tiqwa, 49100 Israel
    Stem Cells Dev 17:547-54. 2008
    ..Moreover, the induced cells secreted dopamine in response to depolarization. These results demonstrate the great therapeutic potential of human MSCs in PD...
  23. ncbi Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    C Y Peng
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 277:1501-5. 1997
    ..These results indicate that serine-216 phosphorylation and 14-3-3 binding negatively regulate Cdc25C and identify Cdc25C as a potential target of checkpoint control in human cells...
  24. doi Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease
    Gaëlle Bouchez
    INSERM U930, Laboratory Biophysique médicale and pharmaceutique, UFR Pharmacie, 31 Avenue Monge, Tours, France
    Neurochem Int 52:1332-42. 2008
    ..This cellular approach might be a restorative therapy in Parkinson's disease...
  25. pmc Induction of striatal pre- and postsynaptic damage by methamphetamine requires the dopamine receptors
    Wenjing Xu
    Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10021, USA
    Synapse 58:110-21. 2005
    ..Moreover, since blockade of either receptor subtype protected from METH, the activity of both DA receptor subtypes is required for the induction of toxicity by METH in the striatum...
  26. ncbi Role of oxidative stress in paraquat-induced dopaminergic cell degeneration
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    J Neurochem 93:1030-7. 2005
    ..Thus, paraquat exposure yields a model that emphasizes the susceptibility of dopaminergic neurons to oxidative damage...
  27. pmc Mutant alpha-synuclein overexpression mediates early proinflammatory activity
    Xiaomin Su
    Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Neurotox Res 16:238-54. 2009
    ..Together, these data demonstrate that mutated alpha-synuclein mediates a proinflammatory response in microglia and this activity may participate in PD pathogenesis...
  28. pmc Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons
    K Sawamoto
    Division of Neuroanatomy (D12, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Proc Natl Acad Sci U S A 98:6423-8. 2001
    ..This strategy for isolating an enriched population of DA neurons should be useful for cellular and molecular studies of these neurons and for clinical applications in the treatment of Parkinson's disease...
  29. ncbi Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity
    Giuseppe Battaglia
    Instituto Neuromed Mediterraneo, Pozzilli Isernia 86077, Italy
    J Neurosci 22:2135-41. 2002
    ..We conclude that endogenous activation of mGlu5 receptors enables the development of MA neurotoxicity and that mGlu5 receptor antagonists are neuroprotective without interfering with the primary mechanism of action of MA...
  30. ncbi A modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosets
    Mahmoud M Iravani
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London SE1 1UL, UK
    Eur J Neurosci 21:841-54. 2005
    ..In addition, these partially lesioned animals did not respond to acute treatment with L-DOPA. This primate partial lesions model may be useful for examining potential neuroprotective or neurorestorative agents for PD...
  31. ncbi 14-3-3 proteins mediate an essential anti-apoptotic signal
    S C Masters
    Graduate Program in Molecular and Systems Pharmacology and the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:45193-200. 2001
    ..Inhibition of 14-3-3 may represent a useful therapeutic target for treatment of cancer and other diseases involving inappropriate cell survival...
  32. pmc 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
    A Kumagai
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Mol Biol Cell 9:345-54. 1998
    ..These findings indicate that 14-3-3 proteins act as negative regulators of Cdc25 in controlling the G2-M transition...
  33. ncbi Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis
    Larisa Bobrovskaya
    School of Biomedical Sciences and Hunter Medical Research Institute, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 100:479-89. 2007
    ..Sustained phosphorylation of TH may be a selective target for drugs or pathology in neurons that contain TH and synthesize dopamine, noradrenaline or adrenaline...
  34. ncbi 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
    H Hermeking
    Johns Hopkins Oncology Center, Baltimore, Maryland, USA
    Mol Cell 1:3-11. 1997
    ..As the fission yeast 14-3-3 homologs rad24 and rad25 mediate similar checkpoint effects, these results document a molecular mechanism for G2/M control that is conserved throughout eukaryotic evolution and regulated in human cells by p53...
  35. ncbi Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis
    Amit Saraf
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 282:573-80. 2007
    ..In summary, we show that B'beta recruits PP2A to modulate TH activity in a tissue- and cell compartment specific fashion...
  36. pmc The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity
    David M Thomas
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Neurochem 105:605-16. 2008
    ..Our results also suggest that reactants derived from METH-induced oxidation of released DA may serve as neuronal signals that lead to microglial activation early in the neurotoxic process associated with METH...
  37. ncbi Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development
    Soojin Ryu
    Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Curr Biol 17:873-80. 2007
    ..Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system...
  38. ncbi Evolution of the 14-3-3 protein family: does the large number of isoforms in multicellular organisms reflect functional specificity?
    M Rosenquist
    Department of Plant Biochemistry, Lund University, P O Box 117, SE 221 00 Lund, Sweden
    J Mol Evol 51:446-58. 2000
    ..Thus, our data suggest that one reason for the large number of isoforms found in multicellular organisms is isoform-specific functions...
  39. ncbi The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
    T Beck
    Department of Biochemistry, Biozentrum, University of Basel, Switzerland
    Nature 402:689-92. 1999
    ..Thus, the TOR signalling pathway broadly controls nutrient metabolism by sequestering several transcription factors in the cytoplasm...
  40. pmc Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
    Hiroshi Kawasaki
    Department of Medical Embryology and Neurobiology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 99:1580-5. 2002
    ..The SDIA method provides an unlimited source of primate cells for the study of pathogenesis, drug development, and transplantation in degenerative diseases such as Parkinson's disease and retinitis pigmentosa...
  41. ncbi Neurotrophin-directed differentiation of human adult marrow stromal cells to dopaminergic-like neurons
    Valerie M Tatard
    INSERM Unit 646, Ingenierie de la Vectorisation Particulaire, 10, rue André Bocquel, 49100 Angers, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, France
    Bone 40:360-73. 2007
    ..MIAMI cells from young and old individuals represent autologous human cell populations for the treatment of disorders of the skeletal and nervous systems and for applications in cell therapy and reparative medicine approaches...
  42. ncbi Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells
    Larisa Bobrovskaya
    The School of Biomedical Sciences, Faculty of Health and Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    J Neurochem 90:857-64. 2004
    ..These data provide the first evidence that the phosphorylation of Ser19 can potentiate the phosphorylation of Ser40 and subsequent activation of tyrosine hydroxylase in intact cells...
  43. ncbi Regulation of CDC25B phosphatases subcellular localization
    N Davezac
    LBCMCP CNRS UMR5088, Universite Paul Sabatier, Toulouse, France
    Oncogene 19:2179-85. 2000
    ..The subcellular localization of CDC25B is therefore dependent on the combined effects of a nuclear localization signal, a nuclear export signal and on the interaction with 14-3-3 proteins...
  44. pmc ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ
    J W Haycock
    Department of Biochemistry, Louisiana State University Medical Center, New Orleans 70119
    Proc Natl Acad Sci U S A 89:2365-9. 1992
    ....
  45. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ....
  46. doi Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
    Lachlan H Thompson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Eur J Neurosci 30:625-38. 2009
    ..Results from testing of amphetamine-induced rotational behaviour suggest, moreover, that dopamine neurons implanted into the substantia nigra are also capable of integrating into the host circuitry at the functional level...
  47. ncbi The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum)
    E Rink
    Brain Research Institute, University of Bremen, P O Box 33 04 40, D 28334, Bremen, Germany
    Brain Res 889:316-30. 2001
    ..They are interpreted as the teleostean dopaminergic system ascending to the striatum, since previous work [16] established that no noradrenergic neurons exist in the forebrain of the adult zebrafish...
  48. pmc RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals
    Sebastian Kowsky
    Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Goettingen, Waldweg 33, D 37073 Goettingen, Germany
    Proc Natl Acad Sci U S A 104:20049-54. 2007
    ..We therefore conclude that RET signaling has no influence on the survival of dopaminergic neurons in the MPTP model of Parkinson's disease but rather facilitates the regeneration of dopaminergic axon terminals...
  49. ncbi Parkinson's disease--redox mechanisms
    J D Adams
    USC School of Pharmacy, 1985 Zonal Avenue, PSC 508, Los Angeles, CA 90089 9121, USA
    Curr Med Chem 8:809-14. 2001
    ..The redox mechanisms of oxygen radical formation by MPTP, tyrosine hydroxylase, monoamine oxidase and aldehyde dehydrogenase will be discussed. Possible clinical applications of these mechanisms will be briefly presented...
  50. pmc The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    J Physiol 577:907-24. 2006
    ..We conclude that reliable physiological criteria for VTA DA neuron identification have yet to be determined, and that the criteria currently being used are unreliable...
  51. ncbi Subcellular localization of 14-3-3 proteins in Toxoplasma gondii tachyzoites and evidence for a lipid raft-associated form
    Olga Assossou
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Equipe d accueil EA 3087 Faculté de Médecine, Universite Claude Bernard, 8 avenue Rockefeller, 69373, Lyon, Cedex 08, France
    FEMS Microbiol Lett 224:161-8. 2003
    ..Two 14-3-3 isoforms were detected. The major one was mainly cytoplasmic and to a lesser extent membrane-associated, whereas the minor isoform was associated with the detergent-resistant lipid rafts...
  52. ncbi 14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation
    Guri Tzivion
    Cardiovascular Research Institute, Division of Molecular Cardiology, Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    J Biol Chem 277:3061-4. 2002
  53. ncbi Leonardo, a Drosophila 14-3-3 protein involved in learning, regulates presynaptic function
    K Broadie
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Neuron 19:391-402. 1997
    ..These results suggest that Leonardo plays a role in the regulation of synaptic vesicle dynamics, a function which may underlie synaptic modulation properties enabling learning...
  54. ncbi Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1
    J Y Toshima
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980 8578, Japan
    J Biol Chem 276:43471-81. 2001
    ..We propose that 14-3-3beta plays important roles in regulating the kinase activity of TESK1 and localizing TESK1 to cell adhesion sites following integrin stimulation...
  55. pmc Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease
    Deniz Kirik
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, BMC A11, 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 100:2884-9. 2003
    ..This model offers new opportunities for the study of pathogenetic mechanisms and exploration of new therapeutic targets of particular relevance to human PD...
  56. ncbi Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Neuropsychopharmacology 30:1324-33. 2005
    ..These results suggest that glutamate, rather than dopamine, is required for the locomotor and molecular effects of NMDA receptor antagonists, but that glutamate and dopamine can act cooperatively...
  57. ncbi Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    J Zha
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 87:619-28. 1996
    ..The rapid phosphorylation of BAD following IL-3 connects a proximal survival signal with the BCL-2 family, modulating this checkpoint for apoptosis...
  58. pmc Involvement of 14-3-3 proteins in nuclear localization of telomerase
    H Seimiya
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    EMBO J 19:2652-61. 2000
    ..14-3-3 binding was not required for telomerase activity either in vitro or in cell extracts. These observations suggest that 14-3-3 enhances nuclear localization of TERT by inhibiting the CRM1 binding to the TERT NES-like motif...
  59. ncbi The role of dopamine in learning, memory, and performance of a water escape task
    Victor H Denenberg
    Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195 7370, USA
    Behav Brain Res 148:73-8. 2004
    ....
  60. ncbi BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanisms
    John D Slonimsky
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Mol Cell Neurosci 23:648-60. 2003
    ..The results of this study indicate that BDNF and CNTF, acting through independent pathways, modulate NE and ACh cotransmission to regulate the level of sympathetic excitation or inhibition of cardiac myocytes...
  61. ncbi Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum
    John W Haycock
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center, New Orleans 70119, USA
    J Neurochem 87:574-85. 2003
    ..This suggests that declines in DA-related function during adulthood and senescence may be explained by losses in DA per se as opposed to DAergic neuropil...
  62. ncbi Early loss of dopaminergic terminals in striosomes after MDMA administration to mice
    Noelia Granado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, CSIC, Madrid 28002, Spain
    Synapse 62:80-4. 2008
    ....
  63. ncbi GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action
    Andreas Schober
    IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurobiol Dis 25:378-91. 2007
    ..We conclude that striatal TGF-beta may be essential for permitting exogenous GDNF to act as a neuroprotective factor...
  64. ncbi Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson's disease
    Lingling Lu
    Beijing Institute for Neuroscience, The Beijing Center of Neural Regeneration and Repairing, Capital University of Medical Sciences, 10 You anMen Wai Xitoutiao, Beijing 100054, P R China
    Brain Res Brain Res Protoc 15:46-51. 2005
    ..05). All the data demonstrated that MSCs could readily be genetically engineered. Therefore, MSCs could be useful gene delivery vehicles of gene therapy for Parkinson's disease...
  65. ncbi Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture
    Thomas C Schulz
    BresaGen Inc, 111 Riverbend Rd, Athens, Georgia, 30605, USA
    Stem Cells 22:1218-38. 2004
    ..This work suggests that hESCs can differentiate in simple serum-free suspension cultures to produce the large number of cells required for transplantation studies...
  66. ncbi Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    Yaping Chu
    Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA
    Neurobiol Dis 25:134-49. 2007
    ..We further hypothesize that preventing the age-related accumulation of non-aggregated alpha-synuclein might be a simple and potent therapeutic target for patients with PD...
  67. ncbi The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
    Amjad Abuirmeileh
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, UK
    Eur J Neurosci 26:417-23. 2007
    ..The apparent ability of UCN to arrest the progression of or even reverse nigral lesions once established suggests that pharmacological manipulation of this system could have substantial therapeutic utility...
  68. ncbi Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    Alison L McCormack
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    Neurobiol Dis 10:119-27. 2002
    ....
  69. ncbi 14-3-3 proteins: key regulators of cell division, signalling and apoptosis
    M J van Hemert
    Section Yeast Genetics, Institute of Molecular Plant Sciences, Leiden University, The Netherlands
    Bioessays 23:936-46. 2001
    ..This article contains supplementary material which may be viewed at the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/Suppmat/23/v23_10.936...
  70. ncbi Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
    C M Cahill
    Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 276:13402-10. 2001
    ..Thus, our results demonstrate at least two mechanisms, one 14-3-3-dependent and the other 14-3-3-independent, whereby PI 3-kinase signaling regulates DAF-16 DNA binding and transcription function...
  71. ncbi Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo
    J Holzschuh
    Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
    Mech Dev 101:237-43. 2001
    ..Neurons expressing th but not dat are adrenergic or noradrenergic, and are found in the locus coeruleus, the medulla, the likely analog of the carotid body, and precursors of the enteric and sympathetic nervous system...
  72. doi Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA
    Sanja Darmopil
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, Avda Dr Arce 37, 28002 Madrid, Spain
    Eur J Neurosci 27:580-92. 2008
    ..Promotion of these striatal TH-ir neurones may be beneficial in Parkinson's disease, particularly in the early stages when dopamine denervation is incomplete...
  73. ncbi Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone
    Sarah A Baker
    Kentucky Spinal Cord Injury Research Center, University of Louisville, 511 S Floyd Street, MDR Room 616, Louisville, KY 40292, USA
    Eur J Neurosci 20:575-9. 2004
    ..This identifies dopamine as one of the few known endogenous regulators of adult neurogenesis with implications for the potential use of endogenous neural precursors in cell replacement strategies for Parkinson's disease...
  74. pmc Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia
    Kenta Sato
    Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 105:12551-6. 2008
    ..We suggest that the differential striosome-matrix pattern of dopamine loss could be a key to identifying the mechanisms underlying the genesis of dystonia in DRD...
  75. ncbi Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost
    Elke Rink
    Brain Research Institute, University of Bremen, Bremen, Germany
    Brain Res Bull 57:385-7. 2002
    ..These double-labeled cells of the posterior tubercle presumably represent the teleostean dopaminergic system ascending to the striatum...
  76. ncbi Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
    O M Schlüter
    Center for Basic Neuroscience, Department of Molecular Genetics, and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Neuroscience 118:985-1002. 2003
    ....
  77. ncbi Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    Naoya Fujita
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 277:28706-13. 2002
    ..p27(Kip1) phosphorylated at Thr(198) exists only in the cytoplasm. Therefore, Akt promotes cell-cycle progression through the mechanisms of phosphorylation-dependent 14-3-3 binding to p27(Kip1) and cytoplasmic localization...
  78. ncbi Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice
    Teresa Gomez-Isla
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Neurobiol Aging 24:245-58. 2003
    ..Thus, high expression of mutant human alpha-synuclein resulted in a progressive motor and widespread CNS gliotic phenotype independent of dopaminergic dysfunction in the Tg5093 line...
  79. ncbi Dopamine depletion impairs precursor cell proliferation in Parkinson disease
    Günter U Höglinger
    INSERM U289 Hôpital de la Salpetrière, F 75651 Paris, France
    Nat Neurosci 7:726-35. 2004
    ..These observations suggest that the generation of neural precursor cells is impaired in Parkinson disease as a consequence of dopaminergic denervation...
  80. ncbi Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors
    Christopher S Hackett
    Department of Neurology, University of California, San Francisco, California 94143 0114, USA
    Cancer Res 63:5266-73. 2003
    ..These data demonstrate conservation of many genetic changes in murine and human neuroblastoma and suggest that further delineation of genetic abnormalities in murine tumors may identify genes important in human disease...
  81. ncbi C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
    C Y Peng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Growth Differ 9:197-208. 1998
    ..Taken together, these results suggest that one function of C-TAK1 may be to regulate the interactions between Cdc25C and 14-3-3 in vivo by phosphorylating Cdc25C on serine 216...
  82. ncbi Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo
    G Tzivion
    Diabetes Unit, The Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 275:29772-8. 2000
    ..Thus, phosphovimentin, by sequestering 14-3-3 and limiting its availability to other target proteins can affect intracellular signaling processes that require 14-3-3...
  83. ncbi Mutations in the hydrophobic surface of an amphipathic groove of 14-3-3zeta disrupt its interaction with Raf-1 kinase
    H Wang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 273:16297-304. 1998
    ..The conservation of the hydrophobic residues Val-176, Leu-216, Leu-220, and Leu-227 among known 14-3-3 family members implies their general importance in ligand binding...
  84. pmc 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
    J A Thorson
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 18:5229-38. 1998
    ..This supports a paradigm in which the effects of phosphorylation on serine as well as tyrosine residues are mediated by inducible protein-protein interactions...
  85. ncbi Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    Xiangmin Peng
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cell Sci 118:3523-30. 2005
    ..Together the data reveal a functional interaction between alpha-synuclein and PP2A that leads to PP2A activation and underscores a key role for alpha-synuclein in protein phosphorylation...
  86. pmc Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Hum Gene Ther 14:415-24. 2003
    ..This improved system efficiently corrects the rat model of PD...
  87. doi Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice
    Noelia Granado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, CSIC, Madrid, Spain
    J Neurochem 107:1102-12. 2008
    ..These data provide the first evidence that MDMA causes persistent loss of dopaminergic cell bodies in the SN...
  88. ncbi Sympathetic activation in adipose tissue and skeletal muscle of hypertensive rats
    Aderville Cabassi
    Laboratory of Clinical Physiology, University of Parma, Italy
    Hypertension 39:656-61. 2002
    ....
  89. ncbi A fetal risk factor for Parkinson's disease
    Brian K Barlow
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Dev Neurosci 26:11-23. 2004
    ..This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD...
  90. pmc The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease
    Oleg S Gorbatyuk
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 105:763-8. 2008
    ..This suggests possible new therapeutic targets for Parkinson Disease...
  91. ncbi Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki shi, Japan
    J Hypertens 19:1769-73. 2001
    ..These findings suggest that peripheral systemic injection of TH AS ODN may be effective as hypotensive therapy in SHR...
  92. ncbi Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7
    H Y Kao
    Department of Biochemistry, School of Medicine, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Biol Chem 276:47496-507. 2001
    ..The data also show that the cellular concentration of factors such as 14-3-3, CaMK I, and other yet unknown molecules may determine the subcellular localization of an individual HDAC member in a cell type and HDAC-specific manner...
  93. ncbi Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein
    Robert E Drolet
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48823, USA
    J Neurochem 96:950-9. 2006
    ..The present study supports the hypothesis that alpha-synuclein functions as a molecular chaperone protein that regulates the phosphorylation state of TH in a substrate and activity-dependent manner...
  94. ncbi A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?
    K Ossowska
    Department of Neuro Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St, 31 343 Krakow, Poland
    Eur J Neurosci 22:1294-304. 2005
    ....
  95. ncbi Phylogenetic investigation of Dogiel's pericellular nests and Cajal's initial glomeruli in the dorsal root ganglion
    Seiji Matsuda
    Department of Anatomy and Embryology, Ehime University School of Medicine, Toon, Ehime 791 0295, Japan
    J Comp Neurol 491:234-45. 2005
    ..Such TH-positive PCNs disappear after sympathectomy. These results suggest that the PCNs are made up of autonomic nerve fibers...
  96. ncbi Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association
    R Kleppe
    Department of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
    J Neurochem 77:1097-107. 2001
    ..These findings further support a role for 14-3-3 proteins in the regulation of catecholamine biosynthesis and demonstrate isoform specificity for both TH and 14-3-3 proteins...
  97. doi Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity
    David M Thomas
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
    J Neurochem 109:1745-55. 2009
    ..Recruitment of the NAc as a target of METH neurotoxicity by alterations in DA homeostasis is significant in light of the important roles played by this brain structure...
  98. ncbi Caffeine stimulates Ca(2+) entry through store-operated channels to activate tyrosine hydroxylase in bovine chromaffin cells
    Sacha McKenzie
    Department of Pharmacology, University of Melbourne, VIC 3010, Australia
    Eur J Neurosci 15:1485-92. 2002
    ..They also suggest that extracellular Ca(2+) entry through such channels regulates cellular responses differently to Ca(2+) entry through voltage-operated Ca(2+) channels...
  99. ncbi Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines
    Melisa J Baptista
    Laboratory of Neurogenetics, National Institute on Aging NIH, Building 10 Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Neurochem 85:957-68. 2003
    ..Reduced expression of the orphan nuclear receptor Nurr1 was also noted, suggesting that the co-ordinate regulation of dopamine synthesis is regulated through this transcription factor...
  100. ncbi 14-3-3 proteins: regulation of subcellular localization by molecular interference
    A J Muslin
    Center for Cardiovascular Research, Department of Medicine, School of Medicine, Washington University, Box 8086 Cardiology, 660 South Euclid Avenue, 63110, St Louis, MO, USA
    Cell Signal 12:703-9. 2000
    ..14-3-3 may affect the localization of a protein by interfering with the function of a nearby targeting sequence, such as a nuclear localization sequence (NLS) or a nuclear export sequence (NES), on the binding partner...
  101. ncbi Dopamine D(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum
    N Lindgren
    Department of Neuroscience, Karolinska Institutet, , S-171 77, Stockholm, Sweden
    Eur J Neurosci 13:773-80. 2001
    ..They also provide a molecular mechanism accounting for the ability of dopamine D(2) autoreceptors to inhibit dopamine synthesis and release from nigrostriatal nerve terminals...

Research Grants178 found, 100 shown here

  1. NEUROTOXIC AMPHETAMINES RADICALS AND 5HT NEURONS
    DONALD KUHN; Fiscal Year: 1999
    ..Increases in brain levels of BH4 will test the hypothesis that the TPH cofactor can modulate the in vivo inactivation of TPH caused by MDMA as it does in vitro with NO/ROS. ..
  2. NEUROTOXIC AMPHETAMINES RADICAL & 5HT NEURONS
    DONALD KUHN; Fiscal Year: 2004
    ..These studies will test novel hypotheses relating to the identification of reactive species that mediate METH and MDMA effects on monoamine nerve endings. ..
  3. PKC SIGNALING AND THE TREATMENT OF BIPOLAR DISORDER
    DONALD KUHN; Fiscal Year: 2002
    ....
  4. MICROARRAY ANALYSIS OF HUMAN COCAINE ADDICTS
    DONALD KUHN; Fiscal Year: 2002
    ..Microarray-based scanning of the human genome has the potential to establish those genes or gene clusters that define the addictive phenotype, leading the way to proteomic-based studies of the bases of addiction. ..
  5. MOLECULAR ANALYSIS OF THE DROSOPHILA GABA TRANSPORTERS
    Wendi Neckameyer; Fiscal Year: 2001
    ....
  6. NEUROSCIENCE TRAINING IN DRUG ABUSE
    DONALD KUHN; Fiscal Year: 2004
    ..abstract_text> ..
  7. Methamphetamine Neurotoxicity and Microglial Activation
    DONALD KUHN; Fiscal Year: 2009
    ..A better understanding of the mechanisms by which METH causes persistent damage to the DA neuronal system could lead to more targeted therapies and would open newer lines of investigation into this and other neurotoxic drugs of abuse. ..
  8. Neurotoxic Amphetamines Radicals & 5HT Neurons
    DONALD KUHN; Fiscal Year: 2009
    ..Research in this proposal is especially relevant to AIDS- related neuropathology, Parkinson's disease, and other neurodegenerative conditions in which microglial activation contributes to CNS damage. ..
  9. Neurotoxic Amphetamines Radicals & 5HT Neurons
    Donald M Kuhn; Fiscal Year: 2010
    ..Research in this proposal is especially relevant to AIDS- related neuropathology, Parkinson's disease, and other neurodegenerative conditions in which microglial activation contributes to CNS damage. ..
  10. Hormonal Factors and Recruitment of Neurons into the Stress Response Circuitry
    Wendi S Neckameyer; Fiscal Year: 2010
    ..This will provide a unique and innovative approach to modeling the development and organization of the stress circuitry in mammals. ..
  11. Neurotoxic Amphetamines Radicals & 5HT Neurons
    DONALD KUHN; Fiscal Year: 2007
    ..Research in this proposal is especially relevant to AIDS- related neuropathology, Parkinson's disease, and other neurodegenerative conditions in which microglial activation contributes to CNS damage. ..
  12. Molecular Neurobiology of Drug Abuse
    DONALD KUHN; Fiscal Year: 2006
    ..Kuhn will remain extensively engaged in scientific mentoring activities. ..
  13. Sympathetic Ganglia: New Target for ACTH with Stress
    Esther Sabban; Fiscal Year: 2007
    ..abstract_text> ..
  14. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 2006
    ..These findings will contribute to the development of new strategies to prevent the harmful maladaptive changes in catecholamine neurotransmission, while enhancing its beneficial adaptive aspects ..
  15. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 2000
    ....
  16. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 1993
    ....
  17. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001
    ....
  18. HYPOPHYSIOTROPIC NEURON DIFFERENTIATION: TARGET FEEDBACK
    Carol Phelps; Fiscal Year: 1993
  19. CELLULAR REGULATION OF TYROSINE HYDROXYLASE
    John Haycock; Fiscal Year: 2001
    ..The effects of haloperidol on Ser19, Ser3l, and Ser4O phosphorylation will be studied by immunohistochemical and blot immunolabeling procedures using site- and phosphorylation state-specific antibodies. ..
  20. Estrogen-Opioid interactions in hippocampus
    TERESA MILNER; Fiscal Year: 2007
    ..The results will elucidate potential mechanisms and sites where ovarian steroids, by affecting HF opioid systems, may influence hippocampal-dependent learning relevant to drug abuse. ..
  21. Iron Acquisition Mechanisms in Oligodendrocytes
    JAMES ROBERT CONNOR; Fiscal Year: 2010
    ..abstract_text> ..
  22. Cannabinoid and Cpioid Interactions in Noradrenergic Cells
    JILLIAN SCAVONE; Fiscal Year: 2007
    ..Cannabinoids may also influence the way pain signaling is processed by the locus coeruleus, revealing a potential new target for pain therapeutics. ..
  23. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 2004
    ..These studies will provide novel and relevant Information as to the contribution of VMAT2-containing vesicles in neuroprotection as well as in neurodegeneration under conditions of a metabolic stress. ..
  24. Adenosine, Glutamate and Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2007
    ....
  25. Translocation and Function of Nuclear Ferritin
    James Connor; Fiscal Year: 2004
    ..abstract_text> ..
  26. ALPHA-1 ADRENERGIC SYSTEM IN ACTIVITY AND DEPRESSION
    Eric A Stone; Fiscal Year: 2010
    ..The research will likely identify the EPI/alpha-1 system as a new and important target for antidepressant and antistress medications ..
  27. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  28. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    PATRICIA SONSALLA; Fiscal Year: 2005
    ..abstract_text> ..