fatty acid desaturases

Summary

Summary: A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. They function by a mechanism that is linked directly to reduction of molecular OXYGEN.

Top Publications

  1. ncbi Modulated fatty acid desaturation via overexpression of two distinct omega-3 desaturases differentially alters tolerance to various abiotic stresses in transgenic tobacco cells and plants
    Meng Zhang
    Institute of Horticulture, ARO, The Volcani Center, Bet Dagan, Israel
    Plant J 44:361-71. 2005
  2. pmc Identification of bifunctional delta12/omega3 fatty acid desaturases for improving the ratio of omega3 to omega6 fatty acids in microbes and plants
    Howard G Damude
    Crop Genetics, Pioneer, DuPont Company, DuPont Experimental Station, Wilmington, DE 19880, USA
    Proc Natl Acad Sci U S A 103:9446-51. 2006
  3. ncbi Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes
    Peter Rzehak
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Neuherberg 85764, Germany
    Br J Nutr 101:20-6. 2009
  4. ncbi FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
  5. ncbi Ribozyme termination of RNA transcripts down-regulate seed fatty acid genes in transgenic soybean
    Tony Buhr
    Department of Agronomy, Center for Biotechnology, University of Nebraska Lincoln, Lincoln, NE, USA
    Plant J 30:155-63. 2002
  6. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
  7. ncbi Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults
    Diana M Merino
    University of Guelph, Department of Human Health and Nutritional Sciences, Guelph, Canada N1G 2W1
    Mol Genet Metab 103:171-8. 2011
  8. pmc FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    Rasika A Mathias
    Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Lipid Res 51:2766-74. 2010
  9. pmc Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis
    J Okuley
    Institute of Biological Chemistry, Washington State University, Pullman 99164 6340
    Plant Cell 6:147-58. 1994
  10. pmc High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing
    Qing Liu
    Commonwealth Scientific and Industrial Research Organization Plant Industry, P O Box 1600, Canberra, Australian Capitol Territory 2601, Australia
    Plant Physiol 129:1732-43. 2002

Research Grants

Detail Information

Publications245 found, 100 shown here

  1. ncbi Modulated fatty acid desaturation via overexpression of two distinct omega-3 desaturases differentially alters tolerance to various abiotic stresses in transgenic tobacco cells and plants
    Meng Zhang
    Institute of Horticulture, ARO, The Volcani Center, Bet Dagan, Israel
    Plant J 44:361-71. 2005
    ..These findings suggest that a drought-induced decreased level of linolenic acid reflects damage. Our results point to the potential of exploiting FAD overexpression as a tool to ameliorate drought tolerance...
  2. pmc Identification of bifunctional delta12/omega3 fatty acid desaturases for improving the ratio of omega3 to omega6 fatty acids in microbes and plants
    Howard G Damude
    Crop Genetics, Pioneer, DuPont Company, DuPont Experimental Station, Wilmington, DE 19880, USA
    Proc Natl Acad Sci U S A 103:9446-51. 2006
    ..The bifunctional activity of these desaturases distinguishes them from all known Delta12 or omega3 fatty acid desaturases. The omega3 desaturase activity of these enzymes also shows a broad omega6 fatty acid substrate ..
  3. ncbi Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes
    Peter Rzehak
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Neuherberg 85764, Germany
    Br J Nutr 101:20-6. 2009
    ..We provide the first replication of the association of the FADS1 FADS2 gene cluster with PUFA in blood phospholipids. For the first time, such associations were also shown for PUFA in cell membranes...
  4. ncbi FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
    ..Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity...
  5. ncbi Ribozyme termination of RNA transcripts down-regulate seed fatty acid genes in transgenic soybean
    Tony Buhr
    Department of Agronomy, Center for Biotechnology, University of Nebraska Lincoln, Lincoln, NE, USA
    Plant J 30:155-63. 2002
    ..Thus, ribozyme termination of transcripts can be utilized to specifically down-regulate endogenous gene expression in soybean...
  6. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  7. ncbi Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults
    Diana M Merino
    University of Guelph, Department of Human Health and Nutritional Sciences, Guelph, Canada N1G 2W1
    Mol Genet Metab 103:171-8. 2011
    Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been examined ..
  8. pmc FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    Rasika A Mathias
    Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Lipid Res 51:2766-74. 2010
    ....
  9. pmc Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis
    J Okuley
    Institute of Biological Chemistry, Washington State University, Pullman 99164 6340
    Plant Cell 6:147-58. 1994
    ..Such a position would facilitate interaction between the desaturase and cytochrome b5, which is the direct source of electrons for the desaturation reaction, but would limit interaction of the active site with the fatty acyl substrate...
  10. pmc High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing
    Qing Liu
    Commonwealth Scientific and Industrial Research Organization Plant Industry, P O Box 1600, Canberra, Australian Capitol Territory 2601, Australia
    Plant Physiol 129:1732-43. 2002
    ....
  11. ncbi Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    Manabu T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Annu Rev Nutr 24:345-76. 2004
    b>Fatty acid desaturases introduce a double bond in a specific position of long-chain fatty acids, and are conserved across kingdoms...
  12. ncbi Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004
    ..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs...
  13. ncbi Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    Linda Schaeffer
    GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Hum Mol Genet 15:1745-56. 2006
    ..0 x 10(-13)). Carriers of the rare alleles of several SNPs and their respective haplotypes had a lower prevalence of allergic rhinitis and atopic eczema. No association was found for total and specific IgE levels...
  14. ncbi Metabolic engineering of omega-3 long-chain polyunsaturated fatty acids in plants using an acyl-CoA Delta6-desaturase with omega3-preference from the marine microalga Micromonas pusilla
    James R Petrie
    Food Futures National Research Flagship, CSIRO Plant Industry, PO Box 1600, Canberra, ACT 2601, Australia
    Metab Eng 12:233-40. 2010
    ..Phylogenetic analysis indicates that this desaturase shares highly conserved motifs with previously described acyl-CoA Delta6-desaturases...
  15. ncbi Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Curr Opin Lipidol 21:64-9. 2010
    ..The present review summarizes the recent association studies on FADS genotypes and LC-PUFA levels and suggests ideas how FADS genotypes can be integrated in future research...
  16. pmc New insight into Phaeodactylum tricornutum fatty acid metabolism. Cloning and functional characterization of plastidial and microsomal delta12-fatty acid desaturases
    Frederic Domergue
    Institut fur Allgemeine Botanik, Universitat Hamburg, Ohnhorststrasse 18, Germany
    Plant Physiol 131:1648-60. 2003
    ..In this report, we describe the characterization of two cDNAs having sequence homology to Delta12-fatty acid desaturases from higher plants...
  17. ncbi FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease
    Jung Hyun Kwak
    Interdisciplinary Course of Science for Aging, Yonsei University, Seoul, South Korea
    Atherosclerosis 214:94-100. 2011
    ..We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans...
  18. ncbi SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease
    Giovanni Malerba
    Department of Mother and Child, and Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Lipids 43:289-99. 2008
    ....
  19. ncbi Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
    Yingchang Lu
    Division of Human Nutrition, Wageningen University Research Center, Wageningen, Netherlands
    Am J Clin Nutr 92:258-65. 2010
    ..Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies...
  20. ncbi Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Janine Kröger
    Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Am J Clin Nutr 93:127-42. 2011
    ..The long-term role of fatty acids (FAs) in the cause of diabetes remains largely unclear...
  21. ncbi Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea
    X Qiu
    Department of Research and Development, Bioriginal Food and Science Corporation, Saskatoon, Saskatchewan, S7J 0R1, Canada
    J Biol Chem 276:31561-6. 2001
    ..of two cDNAs, Fad4 and Fad5, coding for Delta 4 and Delta 5 fatty acid desaturases, respectively...
  22. ncbi Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis
    Frederic Domergue
    Institut fur Allgemeine Botanik, Universitat Hamburg, Hamburg, Germany
    Eur J Biochem 269:4105-13. 2002
    ..This marine diatom was used for cloning genes encoding fatty acid desaturases involved in eicosapentaenoic acid biosynthesis...
  23. pmc Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco
    O Sayanova
    Institute of Arable Crops Research Long Ashton Research Station, University of Bristol, United Kingdom
    Proc Natl Acad Sci U S A 94:4211-6. 1997
    ..6% of the total fatty acids, respectively. The borage delta6-fatty acid desaturase differs from other desaturase enzymes, characterized from higher plants previously, by the presence of an N-terminal domain related to cytochrome b5...
  24. pmc Arabidopsis fatty acid desaturase FAD2 is required for salt tolerance during seed germination and early seedling growth
    Jiantao Zhang
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e30355. 2012
    b>Fatty acid desaturases play important role in plant responses to abiotic stresses. However, their exact function in plant resistance to salt stress is unknown...
  25. ncbi Cloning of a novel omega-6 desaturase from flax (Linum usitatissimum L.) and its functional analysis in Saccharomyces cerevisiae
    Rupali M Khadake
    Bharati Vidyapeeth University, Pune, India
    Mol Biotechnol 42:168-74. 2009
    ..25 and 8.85%, respectively. However, exogenously supplied linoleic acid was feebly converted to linolenic acid suggesting that LuFAD2-2 encodes a functional FAD2 enzyme and has substrate specificity similar to LuFAD2...
  26. ncbi Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention
    Eva Warensjo
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 18:683-90. 2008
    ..Data on how the markers of desaturase activities are modified by changes in dietary fat quality are lacking and therefore warrant examination...
  27. ncbi Desaturation and elongation of Fatty acids and insulin action
    B Vessby
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, University of Uppsala, Sweden
    Ann N Y Acad Sci 967:183-95. 2002
    ..The activity of the fatty acid desaturases is regulated by long-chain polyunsaturated fatty acids and insulin and is probably also dependent on the ..
  28. ncbi Mutants of Arabidopsis reveal many roles for membrane lipids
    James G Wallis
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Prog Lipid Res 41:254-78. 2002
    ....
  29. ncbi alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction
    Ana Baylin
    Department of Community Health, Brown University, Providence, RI, USA
    Am J Clin Nutr 85:554-60. 2007
    ..Delta(6)-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway...
  30. pmc Regulation of membrane fatty acid composition by temperature in mutants of Arabidopsis with alterations in membrane lipid composition
    Deane L Falcone
    Department of Agronomy and the Kentucky Tobacco Research and Development Center, University of Kentucky, Lexington, KY 40546, USA
    BMC Plant Biol 4:17. 2004
    ..To explore the regulation of the membrane composition and photosynthetic function in response to temperature, we examined the effect of temperature in a collection of mutants with altered membrane lipid fatty acid composition...
  31. pmc A large and functionally diverse family of Fad2 genes in safflower (Carthamus tinctorius L.)
    Shijiang Cao
    Commonwealth Scientific and Industrial Research Organization Plant Industry, PO Box 1600, Canberra, ACT 2601, Australia
    BMC Plant Biol 13:5. 2013
    ..In this study, our objective was to identify FAD2 genes from safflower and analyse their differential expression profile and potentially diversified functionality...
  32. pmc In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri
    Frederic Domergue
    Biozentrum Klein Flottbek, Universitat Hamburg, Ohnhorststrasse 18, 22609 Hamburg, Germany
    Biochem J 389:483-90. 2005
    ..Altogether, our data suggest that this desaturase from O. tauri is an acyl-CoA Delta6-desaturase, the first one cloned from a photosynthetically active organism...
  33. ncbi Fatty acid desaturases from the microalga Thalassiosira pseudonana
    Thierry Tonon
    CNAP, Department of Biology, University of York, Heslington, York, UK
    FEBS J 272:3401-12. 2005
    ..Furthermore, we show that one of the remaining genes, TpdesB, encodes a Delta8-sphingolipid desaturase with strong preference for dihydroxylated substrates...
  34. pmc Evolution of moth sex pheromones via ancestral genes
    Wendell L Roelofs
    Department of Entomology, Cornell University, Geneva, NY 14456, USA
    Proc Natl Acad Sci U S A 99:13621-6. 2002
    ..Their presence would allow for asymmetric tracking of male response to the new blend and, thus, evolution of an Ostrinia species with structurally different sex pheromone components...
  35. ncbi Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini
    Andrew W McCartney
    Department of Botany, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Plant J 37:156-73. 2004
    b>Fatty acid desaturases (FADs) play a prominent role in plant lipid metabolism and are located in various subcellular compartments, including the endoplasmic reticulum (ER)...
  36. pmc Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance
    Eva Warensjo
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Lipids Health Dis 8:37. 2009
    ..D5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations...
  37. ncbi Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study
    Eva Warensjo
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 88:203-9. 2008
    ..Desaturase indexes, as markers of endogenous fatty acid desaturation, and a characteristic serum fatty acid (FA) composition are related to cardiovascular and metabolic diseases, but the relation to mortality is poorly investigated...
  38. ncbi Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants
    Baoxiu Qi
    School of Biological Sciences, University of Bristol, BS8 1UG, England, UK
    Nat Biotechnol 22:739-45. 2004
    ..The accumulation of EPA and AA in transgenic plants is a breakthrough in the search for alternative sustainable sources of fish oils...
  39. ncbi Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Clin Nutr 29:277-87. 2010
    ....
  40. ncbi Isolation and characterisation of a high-efficiency desaturase and elongases from microalgae for transgenic LC-PUFA production
    James R Petrie
    Food Futures National Research Flagship, CSIRO Plant Industry, P O Box 1600, Canberra, ACT 2601, Australia
    Mar Biotechnol (NY) 12:430-8. 2010
    ..In addition, the Delta6-desaturase is homologous with acyl-CoA desaturases and shows a strong preference for the omega3 substrate ALA...
  41. pmc Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice
    Qian Jia
    Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
    Cancer Res 68:3985-91. 2008
    ..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties...
  42. ncbi Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression
    W C Tu
    Foodplus Research Centre, School of Agriculture, Food and Wine, Waite Campus, University of Adelaide, Adelaide, South Australia, Australia
    Prostaglandins Leukot Essent Fatty Acids 83:61-8. 2010
    ....
  43. pmc Vertebrate fatty acyl desaturase with Δ4 activity
    Yuanyou Li
    Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, Guangdong 515063, China
    Proc Natl Acad Sci U S A 107:16840-5. 2010
    ....
  44. pmc Cold affects the transcription of fatty acid desaturases and oil quality in the fruit of Olea europaea L. genotypes with different cold hardiness
    M Matteucci
    Dipartimento di Biologia Ambientale, Sapienza Universita di Roma, Rome, Italy
    J Exp Bot 62:3403-20. 2011
    ..Hypotheses relating FAD desaturation to storage and membrane lipids, and genotype cold hardiness are discussed...
  45. ncbi Effect of different environmental stresses on the expression of oleate desaturase genes and fatty acid composition in olive fruit
    M Luisa Hernandez
    Instituto de la Grasa CSIC, Sevilla, Spain
    Phytochemistry 72:178-87. 2011
    ..The fatty acid analysis revealed the appearance of palmitolinoleic acid only in microsomal lipids, reaching a maximum 3h after wounding...
  46. ncbi Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi
    Olga Sayanova
    Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Phytochemistry 72:594-600. 2011
    ....
  47. pmc Metabolic engineering of Saccharomyces cerevisiae for production of Eicosapentaenoic Acid, using a novel {Delta}5-Desaturase from Paramecium tetraurelia
    Sabina Tavares
    Terranol A S, Søltofts Plads b 223, 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 77:1854-61. 2011
    ..Saccharomyces cerevisiae using glucose as the sole carbon source through expression of five heterologous fatty acid desaturases and an elongase...
  48. ncbi Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.)
    Xueyi Hu
    Dow AgroSciences, LLC, 9330 Zionsville Road, Indianapolis, IN 46268 1054, USA
    Theor Appl Genet 113:497-507. 2006
    ..These markers will be highly useful for direct selection of desirable fad2 and fad3c alleles during marker-assisted trait introgression and breeding of canola with high oleic and low linolenic acid...
  49. ncbi Development of ultra-high erucic acid oil in the industrial oil crop Crambe abyssinica
    Xueyuan Li
    Department of Plant Breeding and Biotechnology, Swedish University of Agricultural Sciences, Sweden
    Plant Biotechnol J 10:862-70. 2012
    ....
  50. ncbi FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents
    Julie Dumont
    INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France, UDSL, Lille 59000, France
    J Nutr 141:1247-53. 2011
    ..01). These results suggest that dietary ALA intake modulates the association between FADS1 rs174546 and serum total and non-HDL-cholesterol concentrations at a young age...
  51. pmc Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C
    S Hellstrand
    Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmo, Lund University, Sweden
    J Lipid Res 53:1183-9. 2012
    ..Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL...
  52. pmc Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life
    Peter Rzehak
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    PLoS ONE 5:e13261. 2010
    ..We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied...
  53. ncbi cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family
    A Marquardt
    Institute of Human Genetics, University of Wurzburg, Wurzburg, 97074, Germany
    Genomics 66:175-83. 2000
    ..Protein database searches identified FADS1, FADS2, and FADS3 as fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion...
  54. ncbi Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the
    Eva Lattka
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Clin Nutr 93:382-91. 2011
    ....
  55. pmc Temperature-sensitive post-translational regulation of plant omega-3 fatty-acid desaturases is mediated by the endoplasmic reticulum-associated degradation pathway
    Jami B O'Quin
    Department of Biological Sciences, University of New Orleans, New Orleans, Louisiana 70124, USA
    J Biol Chem 285:21781-96. 2010
    ....
  56. pmc Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome
    Susan Sergeant
    The Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Br J Nutr 107:547-55. 2012
    ..These differences may provide a genetic mechanism contributing to health disparities between populations of African and European descent...
  57. pmc Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model
    Yang Yi Fan
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
    J Lipid Res 53:1287-95. 2012
    ..We propose that this new mouse model will expand our understanding of how AA and its metabolites mediate inflammation and promote malignant transformation, with the eventual goal of identifying new drug targets upstream of Ptgs2...
  58. pmc Key biosynthetic gene subfamily recruited for pheromone production prior to the extensive radiation of Lepidoptera
    Marjorie A Liénard
    Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Ecology Building, SE 22362, Lund, Sweden
    BMC Evol Biol 8:270. 2008
    ....
  59. ncbi A bifunctional oleate 12-hydroxylase: desaturase from Lesquerella fendleri
    P Broun
    Carnegie Institution of Washington, Department of Plant Biology, Stanford, CA 94305, USA
    Plant J 13:201-10. 1998
    ..Fusion of the 5' flanking region of the LFAH12 gene to the beta-glucuronidase coding sequence resulted in a high level of early seed-specific expression of beta-glucuronidase activity in transgenic Arabidopsis plants...
  60. pmc Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions
    Xue Rong Zhou
    Commonwealth Scientific and Industrial Research Organisation Plant Industry, G P O Box 1600, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 286:43644-50. 2011
    ..elegans Δ12-desaturase CeFAT-2 might have arisen independently from other reported dual Δ12/Δ15-desaturases from fungi and protozoa...
  61. pmc Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death
    Dong Wei
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 59:471-8. 2010
    ..To evaluate the direct impact of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the functions and viability of pancreatic beta-cells...
  62. ncbi Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health
    Claudia Glaser
    Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Lindwurmstrasse 4, Munich, Germany
    Matern Child Nutr 7:27-40. 2011
    ....
  63. ncbi Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
    Eva Warensjo
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Box 609, 751 25 Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 16:128-36. 2006
    ..In conclusion, this study shows that a changed FA profile in serum cholesteryl esters and estimated desaturase activities are associated with obesity and lifestyle factors in men and women...
  64. pmc A mutation with major effects on Drosophila melanogaster sex pheromones
    Fabrice Marcillac
    Unité de Recherche 5548 Associée au Centre National de la Recherche Scientifique, Faculte des Sciences, Universite de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France
    Genetics 171:1617-28. 2005
    ..simulans, which shows no sexually dimorphic hydrocarbons. We also induced a larval-lethal allele that lacked all transcripts and failed to complement the defective hydrocarbon phenotype of mutant alleles...
  65. ncbi A palmitoyl-CoA-specific delta9 fatty acid desaturase from Caenorhabditis elegans
    J L Watts
    Institute of Biological Chemistry, Washington State University, Pullman 99164 6340, USA
    Biochem Biophys Res Commun 272:263-9. 2000
    ..This is the first report of a palmitoyl-CoA-specific membrane fatty acid desaturase...
  66. ncbi Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children
    Berthold Koletzko
    Department of Pediatrics, Dr von Hauner Children s Hospital, University of Munich Medical Center, Munich, Germany
    Am J Clin Nutr 93:211-9. 2011
    ..Associations with docosahexaenoic acid (DHA), which is considered particularly important for brain and retina development, are hardly existent...
  67. ncbi Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation
    Lin Xie
    Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People s Republic of China
    J Nutr 138:2222-8. 2008
    ..We showed that genetic variants of FADS1 and FADS2 influence blood lipid and breast milk essential fatty acids in pregnancy and lactation...
  68. pmc A fatty acid desaturase modulates the activation of defense signaling pathways in plants
    P Kachroo
    Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 98:9448-53. 2001
    ..Because reduced S-ACP DES activity leads to the induction of certain defense responses and the inhibition of others, we propose that a FA-derived signal modulates crosstalk between different defense signaling pathways...
  69. pmc Genetic variation in lipid desaturases and its impact on the development of human disease
    Diana M Merino
    University of Guelph, Department of Human Health and Nutritional Sciences, Guelph N1G 2W1, Canada
    Lipids Health Dis 9:63. 2010
    ..Recent evidence indicates that fatty acid desaturases have an important role in defining plasma and tissue lipid profiles...
  70. pmc Adenoviral gene transfer of Caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
    Z B Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:4050-4. 2001
    ..This study demonstrates an effective approach to modifying fatty acid composition of mammalian cells and also provides a basis for potential applications of this gene transfer in experimental and clinical settings...
  71. pmc Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios
    Szilvia Bokor
    INSERM U744, Institut Pasteur de Lille, Univ Lille Nord de France, UDSL, 59019 Lille, France
    J Lipid Res 51:2325-33. 2010
    ..These results suggest that rare alleles of several SNPs in the FADS gene cluster are associated with higher D6D activity and lower D5D activity in European adolescents...
  72. ncbi Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a delta6 desaturase of Atlantic salmon
    Xiaozhong Zheng
    Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, United Kingdom
    Lipids 40:13-24. 2005
    ..cytochrome b5 domain containing the heme-binding motif HPGG, all of which are characteristic of microsomal fatty acid desaturases. Functional expression showed that this gene possessed predominantly delta6 desaturase activity...
  73. ncbi Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    Johannes Nowak
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 28:1991-5. 2007
    ..These results support a protective role of n-3 PUFA supplementation in the prevention of CRC...
  74. pmc Low oleic acid-derived repression of jasmonic acid-inducible defense responses requires the WRKY50 and WRKY51 proteins
    Qing Ming Gao
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Physiol 155:464-76. 2011
    ..Exogenous SA inhibited JA-inducible PDF1.2 expression in the wild type but not in wrky50 or wrky51 mutant plants. These results show that the WRKY50 and WRKY51 proteins mediate both SA- and low-18:1-dependent repression of JA signaling...
  75. pmc Molecular analysis of a bifunctional fatty acid conjugase/desaturase from tung. Implications for the evolution of plant fatty acid diversity
    John M Dyer
    United States Department of Agriculture Agricultural Research Service Southern Regional Research Center, 1100 Robert E Lee Boulevard, New Orleans, Louisiana 70124, USA
    Plant Physiol 130:2027-38. 2002
    ..Phylogenetic analysis revealed that tung FADX is grouped with delta(12) fatty acid desaturases and hydroxylases rather than conjugases, which is consistent with its desaturase activity...
  76. ncbi Formation of conjugated delta8,delta10-double bonds by delta12-oleic-acid desaturase-related enzymes: biosynthetic origin of calendic acid
    E B Cahoon
    DuPont Nutrition and Health, Experimental Station, Wilmington, Delaware 19880 0402, USA
    J Biol Chem 276:2637-43. 2001
    ..Regiospecificity for Delta(9)-double bonds is unprecedented among FAD2-related enzymes and further expands the functional diversity found in this family of enzymes...
  77. pmc Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature
    Hiroshi Maeda
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 20:452-70. 2008
    ..These results provide biochemical and genetic evidence that plastid-synthesized tocopherols modulate ER PUFA metabolism early in the LT adaptation response of Arabidopsis...
  78. ncbi Molecular cloning and characterization of a novel microsomal oleate desaturase gene from soybean
    Lingyong Li
    Nanjing Agricultural University, National Center for Soybean Improvement, National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing 210095, People s Republic of China
    J Plant Physiol 164:1516-26. 2007
    ..These results indicated that the altered polyunsaturated fatty acid levels in leaves treated with cold stress have no direct correlation with the expression of these two microsomal oleate desaturase genes...
  79. ncbi Desaturases from the spotted fireworm moth (Choristoneura parallela) shed light on the evolutionary origins of novel moth sex pheromone desaturases
    Weitian Liu
    Department of Entomology, Cornell University, Geneva, NY 14456, USA
    Gene 342:303-11. 2004
    ....
  80. ncbi Overexpression of a FAD3 desaturase increases synthesis of a polymethylene-interrupted dienoic fatty acid in seeds of Arabidopsis thaliana L
    Debbie Puttick
    Plant Biotechnology Institute, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, Canada
    Lipids 44:753-7. 2009
    ..The results demonstrate that the polymethylene-interrupted dienoic fatty acid, mangiferic acid, can be produced in seed oil through the overexpression of a fatty acid n-3 desaturase...
  81. ncbi Endoplasmic oleoyl-PC desaturase references the second double bond
    J L Schwartzbeck
    Department of Biological Sciences, Clemson University, Clemson, SC 29634-0326, USA
    Phytochemistry 57:643-52. 2001
    ..The rule, Delta(x+3) where x=9 is the double bond location in the substrate, best describes the consistent placement of the second double bond in the above monounsaturated substrates for the oleoyl-PC desaturase of higher plants...
  82. ncbi Comparison of the Delta(12) fatty acid desaturase gene between high-oleic and normal-oleic peanut genotypes
    Shanlin Yu
    State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China
    J Genet Genomics 35:679-85. 2008
    ..These results suggested that the change of AhFAD2B' gene sequence resulted in lower activity or deactivation of Delta(12) fatty acid desaturase in high oleic acid genotype...
  83. ncbi Cloning and transcriptional analysis of Crepis alpina fatty acid desaturases affecting the biosynthesis of crepenynic acid
    Jeong Won Nam
    Department of Chemistry, Washington University in St Louis, One Brookings Drive, Campus Box 1134, St Louis, MO 63130 4899, USA
    J Exp Bot 58:1421-32. 2007
    ..Acetylenase transcription is observed in both species without accumulation of the enzymatic product, crepenynate. Functional expression of acetylenase appears to be affected by competition and collaboration with other enzymes...
  84. ncbi Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana
    Mark A Smith
    Department of Botany, University of British Columbia, Vancouver, Canada
    Planta 217:507-16. 2003
    ..Lipase catalysed 1,3-specific lipolysis of triacylglycerol from transformed plants demonstrated that ricinoleic acid is not excluded from the sn-2 position of triacylglycerol, but is the only hydroxy fatty acid present at this position...
  85. pmc Low temperature and light regulate delta 12 fatty acid desaturases (FAD2) at a transcriptional level in cotton (Gossypium hirsutum)
    Anastasia Kargiotidou
    Institute of Agrobiotechnology, Center for Research and Technology, 6th Km Charilaou, Thermi Road, 570 01 Thermi, Thessaloniki, Greece
    J Exp Bot 59:2043-56. 2008
    ..Delta 12 fatty acid desaturases (FAD2), known to participate in adaptation to low temperatures through acyl chain modifications were used ..
  86. ncbi Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition
    Yanhong Liu
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    Schizophr Res 109:113-20. 2009
    ..Greater Delta6 desaturase expression and activity could have implications for central prostaglandin synthesis and proinflammatory signaling...
  87. pmc Increase of eicosapentaenoic acid in thraustochytrids through thraustochytrid ubiquitin promoter-driven expression of a fatty acid {delta}5 desaturase gene
    Takumi Kobayashi
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Appl Environ Microbiol 77:3870-6. 2011
    ....
  88. ncbi FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies
    M Standl
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Epidemiology I, Ingolstadter Landstrasse 1, Neuherberg, Germany
    Allergy 67:83-90. 2012
    ..Therefore, we evaluated the influence of the FADS1 FADS2 gene cluster polymorphisms on the association between BF and asthma...
  89. ncbi Co-expression of the borage Delta 6 desaturase and the Arabidopsis Delta 15 desaturase results in high accumulation of stearidonic acid in the seeds of transgenic soybean
    Helene Eckert
    Department of Agronomy and Horticulture, University of Nebraska Lincoln, Lincoln, NE 68588 0665, USA
    Planta 224:1050-7. 2006
    ....
  90. ncbi Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster
    H Blanchard
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, Rennes, France
    Biochimie 93:87-90. 2011
    ..Therefore, it is essential to consider the desaturase diversity in terms of catalysis and substrates to elucidate the FADS3 function...
  91. pmc Functional expression of the extraplastidial Arabidopsis thaliana oleate desaturase gene (FAD2) in Saccharomyces cerevisiae
    P S Covello
    National Research Council, Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada
    Plant Physiol 111:223-6. 1996
    ....
  92. ncbi A 'desaturase hypothesis' for atherosclerosis: Janus-faced enzymes in omega-6 and omega-3 polyunsaturated fatty acid metabolism
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro 10, Verona, Italy
    J Nutrigenet Nutrigenomics 2:129-39. 2009
    ..For these reasons, carriers of specific FADS haplotypes may be predisposed to more pronounced vascular inflammatory damage, but also to an increased beneficial effect with omega-3 PUFA supplementation...
  93. ncbi Multiple genes for functional 6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation
    Oscar Monroig
    Institute of Aquaculture, University of Stirling, Stirling FK94LA, Scotland, UK
    Biochim Biophys Acta 1801:1072-81. 2010
    ..The observed differences in tissue expression and nutritional regulation of the fad genes are discussed in relation to gene structures and fish physiology...
  94. ncbi Antisense expression of an Arabidopsis omega-3 fatty acid desaturase gene reduces salt/drought tolerance in transgenic tobacco plants
    Yang Ju Im
    Biotechnology Research Institute, College of Agriculture, Chonnam National University, Kwangju, Korea
    Mol Cells 13:264-71. 2002
    ..However, no significant difference in the ABA concentration was found between the control and the AsFAD716 line under normal and drought conditions...
  95. ncbi Investigation of highly unsaturated fatty acid metabolism in the Asian sea bass, Lates calcarifer
    N Y Mohd-Yusof
    School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia
    Fish Physiol Biochem 36:827-43. 2010
    ..High expression of ∆6 fad and elovl5 genes in brain may indicate a role for these enzymes in maintaining high DHA levels in neural tissues through conversion of 20:5n-3...
  96. ncbi The front-end desaturase: structure, function, evolution and biotechnological use
    Dauenpen Meesapyodsuk
    Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, S7N5A8, Canada
    Lipids 47:227-37. 2012
    ....
  97. ncbi Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes
    Shu Hua Xia
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 26:779-84. 2005
    ....
  98. ncbi FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk
    Carolina Moltó-Puigmartí
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Am J Clin Nutr 91:1368-76. 2010
    ..Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases...
  99. ncbi Seed-specific expression of sesame microsomal oleic acid desaturase is controlled by combinatorial properties between negative cis-regulatory elements in the SeFAD2 promoter and enhancers in the 5'-UTR intron
    Mi Jung Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul, 136 701, South Korea
    Mol Genet Genomics 276:351-68. 2006
    ....
  100. pmc The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures
    M Luisa Hernandez
    Instituto de la Grasa CSIC, Av Padre Garcia Tejero 4, E 41012 Seville, Spain
    J Exp Bot 59:2425-35. 2008
    ..Individual fatty acid desaturases were differently susceptible to environmental stresses with FAD2 being reduced by both high temperature ..
  101. pmc Plastidial fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Cell 15:2952-65. 2003
    ....

Research Grants39

  1. Characterizing the structure of alkane hydroxylase (AlkB) and related diiron enzy
    RACHEL NAREHOOD AUSTIN; Fiscal Year: 2013
    ..Mammalian fatty acids are also desaturated by integral membrane fatty acid desaturases that are structurally quite similar to AlkB...
  2. Pilot Study on Mammary Expression of Novel Desaturases
    ALISON VAN EENENNAAM; Fiscal Year: 2005
    Vertebrates lack the delta-12 and delta-15 fatty acid desaturases responsible for producing the omega-6 and omega-3 polyunsaturated fatty acids (PUFAs), respectively, and hence these PUFAs are essential components of vertebrate diets...
  3. Regulation of stearoyl-CoA desaturases by oleate
    Douglas Thewke; Fiscal Year: 2004
    ..Ectotopic expression of SREBPs or other trans-acting factors will be used to determine their contribution to oleate regulation of SCD transcription. ..
  4. LIPID DEPOSITION IN MAMMALIAN CELLS
    ARTHUR SPECTOR; Fiscal Year: 1980
    ..particularly enzymes involved in lipid metabolism such as NADPH-dependent lipid peroxidation, fatty acid desaturases, acyltransferases involved in phospholipid and triglyceride synthesis and HMGCoA reductase...
  5. ROLE OF IRON-OXO CLUSTERS IN FATTY ACID DESATURATION
    Brian Fox; Fiscal Year: 2007
    b>Fatty acid desaturases produce essential mono- and polyunsaturated lipids and thus help to maintain and control the function of cellular membranes...
  6. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  7. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  8. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 2002
    ..abstract_text> ..
  9. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Molecular and Cellular Biology of Lipids
    Charles Martin; Fiscal Year: 2007
    ..Proper facilities are available to accommodate handicapped individuals who will be considered equally in the selection of attendees and speakers. ..
  11. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  12. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2008
    ..This strengthens evaluation of risk, and application to current dietary goals. The large number of SNPs proposed for final analysis will add to the resolution and power to identify the genes that underlie CHD. ..
  13. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  14. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  15. Integration of Stress and Reproductive Axes by Dopamine
    Simon Evans; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ....
  17. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  18. NOVEL OXYGENATIONS OF ARACHIDONIC ACID
    ALAN BRASH; Fiscal Year: 2006
    ..These studies will develop new insights into the biochemistry of mammalian cyclooxygenases and as a consequence have practical benefits in development of therapeutics. ..
  19. NUCLEOPROTEINS IN MAMMALIAN SPERMATOGENESIS
    Marvin Meistrich; Fiscal Year: 2006
    ..Thus they provide a well-defined model system for study of human infertility. ..
  20. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  21. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2002
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  22. Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis
    Elizabeth Theil; Fiscal Year: 2004
    ..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
  23. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..The use of biomarkers will allow to evaluate the cancer-protective effects of dietary modulation over a relatively short period of time. ..
  24. REGULATION OF BILIPROTEIN IN CYANOBACTERIA
    DONALD BRYANT; Fiscal Year: 2002
    ..These last studies could explain bloom disappearance in natural populations and could suggest new approaches for the control of problematic or toxic cyanobacteria in water supplies. ..
  25. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  26. Structure/Mechanism of an FMN- and FAD-containing Enzyme
    Jung Ja Kim; Fiscal Year: 2005
    ..To determine the structural basis for these differences, it is proposed to determine the crystal structures of (4) the flavin domains and (5) their variants of the three NOSs, containing their respective Ca++/CaM-binding regions. ..
  27. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  28. PATHOPHYSIOLOGICAL ROLE OF 12-R-LIPOXYGENASE
    ALAN BRASH; Fiscal Year: 2002
    ..abstract_text> ..
  29. MEVALONATED METABOLIZING ENZYMES & THEIR INBORN DEFECTS
    Jung Ja Kim; Fiscal Year: 2003
    ..3) High resolution structures of rat and human mevalonate kinases will be determined by X-ray crystallography. (4) Human mevalonate kinase mutants will be modeled to determine the molecular basis for mevalonic aciduria. ..
  30. Workshop on Biolron in Thalassemia & Sickle Cell Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..abstract_text> ..
  31. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..Determine how over expression of specific fatty acid elongases affects hepatic function, blood lipid composition and the onset of chronic disease. ..
  32. MEMBRANE FUNCTION IN MUTANTS OF CAENORHABDITIS ELEGANS
    John Browse; Fiscal Year: 2004
    ..Quantitative measures of low-temperature performance and thermotolerance of the range of desaturase mutants will be correlated with fatty acid composition and measurements of membrane fluidity. ..
  33. GLUCOSE UTILIZATION IN SENESCENT HEARTS
    Rong Tian; Fiscal Year: 2002
    ..Aim 4: To test the hypothesis that presence of high glucose and insulin increase glucose utilization and improves the tolerance toischemia in senescent hearts. ..
  34. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  35. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  36. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  37. Desaturases and Acetylenases from Basidiomycete Fungi
    ROBERT MINTO; Fiscal Year: 2004
    ..Through the above studies, we will test the hypothesis that multiple FAD2-like enzymes are required for polyacetylene biosynthesis, while characterizing an understudied group of important fungal enzymes. ..
  38. Study of Leptin Receptor Deficiency in Fat
    Allan Zhao; Fiscal Year: 2007
    ..We believe that these studies will provide a possible molecular linkage between adipocyte-selective leptin receptor deficiency and type 2 diabetes. ..