Genomes and Genes
Summary: An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 22.214.171.124.
Publications282 found, 100 shown here
- Constituents from the Formosan apple reduce tyrosinase activity in human epidermal melanocytesYi Pei Lin
Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
Phytochemistry 68:1189-99. 2007..Thus, 3-hydroxyphloretin (7) and catechol (9) were the most active constituents from the Formosan apple; they exhibited anti-oxidant and tyrosinase reducing activities, suggesting their possible use as cosmetic agents...
- The proPO-system: pros and cons for its role in invertebrate immunityLage Cerenius
Department of Comparative Physiology, Uppsala University, 752 36 Uppsala, Sweden
Trends Immunol 29:263-71. 2008....
- Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the futureY J Kim
Center for Advanced Science and Innovation, Osaka University, Suita, Osaka, 565 0871, Japan
Cell Mol Life Sci 62:1707-23. 2005..This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance...
- A new 2-imino-1,3-thiazoline derivative, KHG22394, inhibits melanin synthesis in mouse B16 melanoma cellsDong Seok Kim
Department of Dermatology, Seoul National University College of Medicine, Korea
Biol Pharm Bull 30:180-3. 2007..Our findings indicate that 2-imino-1,3-thiazoline derivatives are potential skin whitening agents...
- An updated review of tyrosinase inhibitorsTe Sheng Chang
Department of Biological Science and Technology, National University of Tainan, Taiwan
Int J Mol Sci 10:2440-75. 2009..This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed...
- Role of the prophenoloxidase-activating system in invertebrate immunityK Soderhall
Division of Physiological Mycology, University of Uppsala, Sweden
Curr Opin Immunol 10:23-8. 1998..Several components of this system recently have been isolated and their structure determined...
- Curcumin inhibits melanogenesis in human melanocytesCai Xia Tu
Department of Dermatology, 2nd Affiliated Hospital of Dalian Medical University, Liaoning 116027, PR China
Phytother Res 26:174-9. 2012..These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3β, ERK or p38 MAPK signaling pathways...
- Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cellsJi Yeon Jang
Department of Oriental Medicine, College of Oriental Medicine, Dongeui University, Busan, South Korea
Exp Dermatol 18:232-7. 2009..Therefore, C. heracleifolia would be a useful therapeutic agent for treating hyperpigmentation and an effective component in whitening and/or lightening cosmetics...
- Genetic determinants of hair, eye and skin pigmentation in EuropeansPatrick Sulem
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:1443-52. 2007..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R...
- Chemical and instrumental approaches to treat hyperpigmentationStefania Briganti
San Gallicano Dermatological Institute, Via Elio Chianesi, Rome, Italy
Pigment Cell Res 16:101-10. 2003....
- Glycogen synthase kinase 3beta is activated by cAMP and plays an active role in the regulation of melanogenesisMehdi Khaled
INSERM U385, Biologie et Physiopathologie de la Peau, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France
J Biol Chem 277:33690-7. 2002....
- Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insectsManickam Sugumaran
Department of Biology, University of Massachusetts, Boston, USA
Pigment Cell Res 15:2-9. 2002..indicate that tyrosinase and phenoloxidase are distinctly different enzymes in spite of possessing both monophenol monooxygenase activity as well as o-diphenoloxidase activity...
- Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesisT Kobayashi
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
EMBO J 13:5818-25. 1994..This enzyme activity appears to be essential to the further metabolism of DHICA to a high molecular weight pigmented biopolymer...
- Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysisYasuyuki Matoba
Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
J Biol Chem 281:8981-90. 2006..Our crystallographic study shows evidence that the tyrosinase active center formed by dinuclear coppers is flexible during catalysis...
- Hypopigmenting agents: an updated review on biological, chemical and clinical aspectsFrancisco Solano
Department of Biochemistry and Molecular Biology B, University of Murcia, Murcia, Spain
Pigment Cell Res 19:550-71. 2006..Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase...
- (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidantHui Min Wang
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, and the Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, ROC
Bioorg Med Chem 18:5241-7. 2010..To our knowledge, this is the first study to reveal the bioactivities of (-)-N-formylanonaine from this plant species...
- Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene familyR A Sturm
Centre for Molecular and Cellular Biology, University of Queensland, Australia
Genomics 29:24-34. 1995..The evidence also suggests that at least some of the introns within the TYR, TYRP1, and TYRP2 coding regions were gained after duplication and that intron slippage is unlikely to have occurred...
- p38 regulates pigmentation via proteasomal degradation of tyrosinaseBarbara Bellei
Laboratory of Cutaneous Physiopathology, San Gallicano Dermatologic Institute, IRCCS, 00144 Rome, Italy
J Biol Chem 285:7288-99. 2010....
- Identification and characterization of mouse Rab32 by mRNA and protein expression analysisKarine A Cohen-Solal
Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Biochim Biophys Acta 1651:68-75. 2003..Based on these data, we propose the inclusion of Rab32 to the so-called melanocyte/platelet family of Rab proteins...
- Antimelanogenic and antioxidant properties of gallic acidYou Jung Kim
Department of Cosmetology, Pusan Women s College, Busan, Korea
Biol Pharm Bull 30:1052-5. 2007..Based on these results, I propose that GA exerts antimelanogenic activity coupled with antioxidant properties by suppressing RS generation and maintaining a higher GSH/GSSG ratio...
- Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applicationsS Halaouli
UMR 1163 INRA Université de Provence de Biotechnologie des Champignons Filamenteux, IFR 86 de Biotechnologie Agro Industrielle de Marseille, Marseille Cedex, France
J Appl Microbiol 100:219-32. 2006..Next, their most promising applications in food, pharmaceutical and environmental fields are presented and the bioengineering approaches used for the development of tyrosinase-overproducing fungal strains are discussed...
- Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cellsYan Ye
Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Ethnopharmacol 132:533-5. 2010..In our previous screening assays, SBT was identified as an effective tyrosinase inhibitor. In this study, we aim to investigate the anti-melanogenic effect and mechanisms of SBT in B16 cells...
- Stimulation of melanogenesis by scoparone in B16 melanoma cellsJeong Yeh Yang
Department of Biochemistry, Dental School, Chonbuk National University, Jeonju 561 756, Korea
Acta Pharmacol Sin 27:1467-73. 2006..The effect of coumarin derivatives on melanogenesis was investigated in B16 murine melanoma cells...
- New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteinsConcepcion Olivares
Department of Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Murcia, Espinardo, Spain
Pigment Cell Melanoma Res 22:750-60. 2009..This review summarizes our current knowledge of tyrosinase and Tyrps structure and function and describes the catalytic mechanism of tyrosinase and Dct/Tyrp2, which are better characterized...
- Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmiaC Bertolotto
INSERM U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, Nice, France
Mol Cell Biol 18:694-702. 1998..These convergent and compelling results disclose at least a part of the molecular mechanism involved in the regulation of melanogenic gene expression by cAMP and emphasize the pivotal role of microphthalmia in this process...
- L-DOPA is an endogenous ligand for OA1Vanessa M Lopez
Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, Arizona, USA
PLoS Biol 6:e236. 2008..Our results suggest that the retinal consequences of albinism caused by changes in melanin synthetic machinery may be treated by L-DOPA supplementation...
- Molecular diagnosis of oculocutaneous albinism: new mutations in the OCA1-4 genes and practical aspectsCaroline Rooryck
Pigment Cell Melanoma Res 21:583-7. 2008
- Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytesH Yanase
Technical Research Laboratory, Kurabo Industries Ltd, Osaka, Japan
Pigment Cell Res 14:103-9. 2001....
- Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyriferaHorng Huey Ko
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
J Nat Prod 71:1930-3. 2008..The mild inhibition of tyrosinase and significant inhibition of xanthine oxidase suggests that 1-3 could be useful ingredients in the development of skin-protecting cosmetics...
- Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide systemUraiwan Panich
Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Arch Pharm Res 34:811-20. 2011..We report herein that AA can protect against UVA-dependent melanogenesis possibly through the improvement of antioxidant defense capacity and inhibition of NO production through down-regulation of eNOS and iNOS mRNA...
- Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus)L A Lyons
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
Anim Genet 36:119-26. 2005..Because the same mutations were identified in different breeds with similar phenotypes, the mutations are likely to be identical by descent rather than multiple mutation events occurring at the same site...
- Inhibitory effects of Ramulus mori extracts on melanogenesisKang Tae Lee
Coreana Cosmetics Co, 204 1 JeongchonRi, Senggeoeup, Cheonansi, 330 830, Korea
J Cosmet Sci 54:133-42. 2003..23 microg/ml). Also, R. mori extracts inhibited tyrosinase activity in a competitive manner (Ki = 1.5 x 10(-6) M) when L-tyrosine was used as a substrate...
- Similar enzyme activation and catalysis in hemocyanins and tyrosinasesHeinz Decker
Institut für Molekulare Biophysik, Johannes Gutenberg Universitat, 55099 Mainz, Germany
Gene 398:183-91. 2007..Minor conformational differences at the active site seem to decide about whether the active site is only able to oxidize diphenols as in catecholoxidase or if it is also able to o-hydroxylate monophenols as in tyrosinase...
- Comparison of the characteristics of fungal and plant tyrosinasesEmilia Selinheimo
VTT Technical Research Centre of Finland, P O Box 1000, Espoo FIN 02044 VTT, Finland
J Biotechnol 130:471-80. 2007..In the reaction conditions studied, TrT showed the best ability to crosslink alpha-casein. TrT also had the highest activity on most of the tested monophenols, and showed noticeable short lag periods prior to the oxidation...
- Overexpression of polyphenol oxidase in transgenic tomato plants results in enhanced bacterial disease resistanceLi Li
Department of Plant Breeding and Biometry, 252 Emerson Hall, Cornell University, Ithaca, NY 14853 2901, USA Fax 1 607 2551132
Planta 215:239-47. 2002..These results demonstrate the importance of PPO-mediated phenolic oxidation in restricting plant disease development...
- Temporal patterns in immune responses to a range of microbial insults (Tenebrio molitor)Eleanor R Haine
Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
J Insect Physiol 54:1090-7. 2008..There was no long-lasting upregulation of phenoloxidase activity, suggesting that this immune effector system is not involved in the management of microbial infections over a long time scale...
- Flavonoids, taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levelsSang Mi An
Department of Molecular Medicine, Kyungpook National University School of Medicine, 101 Dongindong 2 ga, Junggu, Daegu, 700 422, Republic of Korea
Phytother Res 22:1200-7. 2008..Therefore, the antimelanogenic effects of taxifolin and luteolin are attributed to their inhibitory effects on tyrosinase enzymatic activity, despite their effects on increasing tyrosinase protein levels...
- Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesisAkira Hachiya
Kao Biological Science Laboratories, Ichikai machi Haga, Tochigi 321 3497 Japan
Am J Pathol 165:2099-109. 2004....
- Tyrosinase stabilization by Tyrp1 (the brown locus protein)T Kobayashi
Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda Maryland 20892, USA
J Biol Chem 273:31801-5. 1998..In sum, these results suggest that, in addition to its catalytic function in oxidizing DHICA, Tyrp1 may play an important role in stabilizing Tyr, a second potential role in the regulation of melanin formation...
- Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalconeWoo Duck Seo
Department of Functional Crop, NICS, RDA, Miryang 627 803, Republic of Korea
Eur J Med Chem 45:2010-7. 2010..The Western blot for expression levels of proteins involved in melanogenesis showed that TSAHC significantly decreased three main tyrosinase related protein in melanin biosynthesis, tyrosinase, TRP-1 and TRP-2...
- Melasma: a comprehensive update: part IIVaneeta M Sheth
Department of Dermatology at Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 65:699-714; quiz 715. 2011..A thorough understanding of the risks and benefits of various therapeutic options is crucial in selecting the best treatment...
- Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cellsJi Yeon Jang
Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Gyeongnam, Republic of Korea
J Ethnopharmacol 137:1207-14. 2011..We investigated the inhibitory activities of Nardostachys chinensis in melanogenesis and its related signaling pathway...
- DNA-based eye colour prediction across Europe with the IrisPlex systemSusan Walsh
Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
Forensic Sci Int Genet 6:330-40. 2012....
- Tyrosinase and related proteins in mammalian pigmentationV del Marmol
LOCE, Institut J Bordet, Universite Libre de Bruxelles, Belgium
FEBS Lett 381:165-8. 1996..We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man...
- New insights into the evolution of metazoan tyrosinase gene familyRosaria Esposito
Cellular and Developmental Biology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy
PLoS ONE 7:e35731. 2012..Collectively, the results reported here enlarge our knowledge about the tyrosinase gene family as valuable resource for understanding the genetic components involved in pigment cells evolution and development...
- Expression of the tyrosinase-encoding gene in a colorless melanophore mutant of the medaka fish, Oryzias latipesH Inagaki
Department of Biology, Faculty of Science, Nagoya University, Japan
Gene 150:319-24. 1994..In the b mutant, contrary to expectation, the mRNA was detected not only in eyes but also in amelanotic skin. Therefore, pigmentation of the skin controlled by b is not directly related to expression of the Tyr gene...
- Role of the C-terminal extension in a bacterial tyrosinaseMichael Fairhead
Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Biomaterials, St Gallen, Switzerland
FEBS J 277:2083-95. 2010..In addition, we show that this enzyme can be readily overproduced and purified and that it will prove useful in furthering the understanding of these enzymes, as well as their biotechnological application...
- Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinaseChin Hui Chen
College of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 11031, Taiwan
Molecules 14:2947-58. 2009..Additional studies are warranted to further characterize the compounds responsible for the antioxidant properties of the examined extracts...
- Expression hierarchy of T cell epitopes from melanoma differentiation antigens: unexpected high level presentation of tyrosinase-HLA-A2 Complexes revealed by peptide-specific, MHC-restricted, TCR-like antibodiesYael Michaeli
Faculty of Biology, Technion Israel Institute of Technology, Haifa, Israel
J Immunol 182:6328-41. 2009..These results may shed new light on relationships between Ag presentation and immune response to cancer Ags...
- Inhibition of melanogenesis by tyrosinase siRNA in human melanocytesSang Mi An
Department of Molecular Medicine and Cell and Matrix Research Institute, BK21 Medical Education Program for Human Resources, Kyungpook National University School of Medicine, Daegu, Korea
BMB Rep 42:178-83. 2009..These results suggest that molecular approaches using siRNA targeted to the enzymes of melanogenic pathway may provide a novel strategy for the control of cell pigmentation...
- Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitorHiroki Satooka
Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, United States
Bioorg Med Chem 20:1090-9. 2012..trans-Pinosylvin, cis-pinosylvin, dihydropinosylvin were also tested for a comparison. These results suggest that possible usage of resveratrol as a tyrosinase inhibitor and a melanogenesis inhibitor...
- The Tyr (albino) locus of the laboratory mouseFriedrich Beermann
ISREC, National Center of Competence in Research NCCR Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Mamm Genome 15:749-58. 2004..We compare eye and skin pigmentation phenotypes and the genetic lesions that cause each. We suggest that this panel of congenic mutants contains rich, untapped resources for the study of many questions of basic cell biological interest...
- Selection for cuticular melanism reveals immune function and life-history trade-offs in Spodoptera littoralisS C Cotter
Department of Biological Sciences, Lancaster Environment Centre, Lancaster University, Lancaster, UK
J Evol Biol 21:1744-54. 2008..In addition, we found that lines with high PO activity had slower development rates suggesting that investment in PO, rather than in melanism, is costly...
- BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytesM L Bilodeau
Basic Medical Sciences Department, Purdue University, West Lafayette, Indiana 47906, USA
Pigment Cell Res 14:328-36. 2001..These studies support a role for BMP-2 in melanogenesis by selectively targeting the expression of the tyrosinase gene involved in melanin biosynthesis...
- Potent virucidal activity in larval Heliothis virescens plasma against Helicoverpa zea single capsid nucleopolyhedrovirusHolly J R Popham
USDA, Agricultural Research Service, Biological Control of Insects Research Laboratory, 1503 S Providence Road, Columbia, MO 65203, USA
J Gen Virol 85:2255-61. 2004..Thus, in the plasma of larval lepidopterans, the enzyme phenol oxidase may act as a constitutive, humoral innate antiviral immune response...
- Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylaseM Rios
Departments of Neuroscience and Anatomy and Cell Biology, Tufts University Medical School, Boston, Massachusetts 02111, USA
J Neurosci 19:3519-26. 1999..Thus, these extraordinary circumstances reveal that tyrosinase serves as an alternative pathway to supply catecholamines...
- Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genesK Yasumoto
Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
J Biol Chem 272:503-9. 1997..These results suggest that MITF is sufficient to direct pigment cell-specific transcription of the tyrosinase and TRP-1 genes but not the TRP-2 gene...
- Tyrosinase/catecholoxidase activity of hemocyanins: structural basis and molecular mechanismH Decker
Institut für Molekulare Biophysik, Johannes Gutenberg Universitat Mainz, D 55099 Mainz, Germany
Trends Biochem Sci 25:392-7. 2000..On the basis of their molecular structures, hemocyanins are used as model systems to understand the substrate-active-site interaction between catecholoxidases and tyrosinases...
- Model-based prediction of human hair color using DNA variantsWojciech Branicki
Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
Hum Genet 129:443-54. 2011....
- Evolution of pigment synthesis pathways by gene and genome duplication in fishIngo Braasch
University of Wurzburg, Physiological Chemistry I, Biozentrum, Am Hubland, Wurzburg, Germany
BMC Evol Biol 7:74. 2007..No systematic genomic inventory allowing to test this hypothesis has been drawn up so far for pigmentation genes in fish, and almost nothing is known about the evolution of these genes in different fish lineages...
- Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesisVanda S Lopes
Molecular and Cellular Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
Mol Biol Cell 18:3914-27. 2007..Together with the high levels of cathepsin D in immature melanosomes of the RPE, our results suggest that melanin deposition may protect the maturing melanosome from the activity of lumenal acid hydrolases...
- Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retinaRivka A Rachel
Center for Neurobiology and Behavior, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 22:4249-63. 2002..These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotype...
- Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinismR Halaban
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 97:5889-94. 2000..From these results we concluded that albinism, at least in part, is an ER retention disease...
- Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiationR Busca
INSERM U385, Faculte de Medecine, 06107 Nice, Cedex 02, France
J Biol Chem 271:31824-30. 1996..Furthermore, we provide evidence which suggests that cAMP-induced melanogenesis and dendricity are, at least partially, mediated by the cAMP inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase signaling pathway...
- Broad-spectrum antimicrobial activity of the reactive compounds generated in vitro by Manduca sexta phenoloxidasePicheng Zhao
Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
Insect Biochem Mol Biol 37:952-9. 2007..g. proteinases, oxidases, and dopachrome conversion enzyme (DCE)), which immobilizes and kills invading microorganisms...
- Phenoloxidase is an important component of the defense against Aeromonas hydrophila Infection in a crustacean, Pacifastacus leniusculusHaipeng Liu
Department of Comparative Physiology, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
J Biol Chem 282:33593-8. 2007..Our data therefore suggest that phenoloxidase is required in crayfish defense against an infection by A. hydrophila, a highly virulent and pathogenic bacterium to crayfish...
- A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomeraseK Tsukamoto
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
EMBO J 11:519-26. 1992..We now report that TRP-2 (tyrosinase related protein-2), which maps to and is mutated at the slaty locus in mice, encodes a protein with DOPAchrome tautomerase activity...
- Bacterial tyrosinasesHarald Claus
Institute for Microbiology and Wine Research, University of Mainz, Becherweg 15, D 55099 Mainz, Germany
Syst Appl Microbiol 29:3-14. 2006..This review summarizes the present knowledge of bacterial tyrosinases, which are promising models in order to get more insights in structure, enzymatic reactions and functions of "type 3 copper" proteins in general...
- The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formationW S Oetting
Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Pigment Cell Res 13:320-5. 2000..Several questions still remain, including cryptic mutations that affect tyrosinase activity and the minimum amount of pigment required for normal optic development. The next 10 years should prove just as exciting as the last...
- Chemical analysis of melanins and its application to the study of the regulation of melanogenesisS Ito
Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
Pigment Cell Res 13:103-9. 2000..In conclusion, our HPLC microanalytical method for characterizing eumelanin and pheomelanin has become a useful tool for the study of melanogenesis...
- Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compoundsTae Young Choi
Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, South Korea
Pigment Cell Res 20:120-7. 2007..We suggest that the zebrafish system is a novel alternative to mammalian models, with several advantages including the rapidity, cost-effectiveness, and physiological relevance...
- Melanin synthesis in microorganisms--biotechnological and medical aspectsPrzemyslaw M Plonka
Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Acta Biochim Pol 53:429-43. 2006..This review summarizes current views on melanogenesis in Pro- and Eukaryotic microorganisms in terms of their biotechnological and biomedical importance...
- Production and characterization of a secreted, C-terminally processed tyrosinase from the filamentous fungus Trichoderma reeseiEmilia Selinheimo
VTT Technical Research Centre of Finland, Espoo, Finland
FEBS J 273:4322-35. 2006..T. reesei TYR2 was active on both l-tyrosine and l-dopa, and it showed broad substrate specificity...
- Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutationD L Imes
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA
Anim Genet 37:175-8. 2006..Taken together, our results suggest that the TYR gene corresponds to the colour locus in cats and its alleles, from dominant to recessive, are as follows: C (full colour) > c(b) (burmese) > or = c(s) (siamese) > c (albino)...
- Inhibition of melanogenesis versus antioxidant properties of essential oil extracted from leaves of Vitex negundo Linn and chemical composition analysis by GC-MSHuey Chun Huang
Department of Medical Laboratory Science and Biotechnology, China Medical University, No 91 Hsueh Shih Road, Taichung City 40402, Taiwan
Molecules 17:3902-16. 2012..negundo Linn leaves decreased melanin production in B16F10 melanoma cells and showed potent antioxidant activities. The essential oil can thereby serve as an inhibitor of melanin synthesis and could also act as a natural antioxidant...
- Genomic structure and evolutionary conservation of the tyrosinase gene family from FuguAgnès Camacho-Hübner
ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066, Epalinges, Switzerland
Gene 285:59-68. 2002..Our results demonstrate the existence of all three tyrosinase family members in teleosts and underline the evolutionary conservation of the pigmentary system...
- Inhibition of melanogenesis and antioxidant properties of Magnolia grandiflora L. flower extractHuey Chun Huang
Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
BMC Complement Altern Med 12:72. 2012..grandiflora L. flower extract on mushroom tyrosinase, B16F10 intracellular tyrosinase activity and melanin content were determined spectrophotometrically. Meanwhile, the antioxidative capacity of the flower extract was also investigated...
- New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active siteUsman Ghani
Department of Medical Biochemistry, King Saud University, Riyadh 11461, Saudi Arabia
Bioorg Med Chem 18:4042-8. 2010..The current work may help develop new potent tyrosinase inhibitors against hyperpigmentation including potential insecticides...
- A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicityPaola Manini
Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Via Cinthia 4, I 80126 Naples, Italy
Chem Res Toxicol 22:1398-405. 2009....
- Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesisUraiwan Panich
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Cell Biol Toxicol 26:103-16. 2010..Inhibiting cellular oxidative stress and improving antioxidant defenses might be the mechanisms by which the extracts yield the protective effects on UVA-dependent melanogenesis...
- Down-regulation of melanogenesis by phospholipase D2 through ubiquitin proteasome-mediated degradation of tyrosinaseAkiko Kageyama
Division of Dermatology, Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
J Biol Chem 279:27774-80. 2004..This suggests that PLD2 may play an important role in regulating pigmentation in vivo...
- Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutationRunsheng Wang
Huffington Center on Aging and Departments of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:353-8. 2006..Our results identify Tyr and related proteins as physiological substrates of PS and link gamma-secretase activity with intracellular protein transport...
- Tyrp1 and oculocutaneous albinism type 3R Sarangarajan
Department of Dermatology, University of Cincinnati College of Medicine, Ohio 45267 0592, USA
Pigment Cell Res 14:437-44. 2001..Tyrp1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and melanocyte cell death. The current review is an attempt to consolidate our understanding of the role of Tyrp1 in the melanocyte...
- Glutaraldehyde activated eggshell membrane for immobilization of tyrosinase from Amorphophallus companulatus: application in construction of electrochemical biosensor for dopamineSanket Tembe
Department of Chemistry, University of Pune, Ganeshkhind, Pune 411007, India
Anal Chim Acta 612:212-7. 2008..19 V versus Ag/AgCl (3M KCl). Linearity was observed within the range of 50-250 microM with a detection limit of 25 microM...
- Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cellsIchiro Yajima
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aramaki Aza Aoba, Aoba ku, Sendai, Miyagi 980 8578, Japan
Mech Dev 120:1489-504. 2003....
- Cloning and characterization of a tyrosinase gene from the white-rot fungus Pycnoporus sanguineus, and overproduction of the recombinant protein in Aspergillus nigerSonia Halaouli
UMR 1163 INRA Université de Provence de Biotechnologie des Champignons Filamenteux, IFR 86 de Biotechnologie Agro Industrielle de Marseille, 163 Avenue de Luminy, Case 925, 13288 Marseille Cedex 09, France
Appl Microbiol Biotechnol 70:580-9. 2006..The best transformant obtained, A. niger D15#26-e, produced extracellular tyrosinase activities of 534 and 1,668 U l(-1) for monophenolase and diphenolase, respectively, which corresponded to a protein yield of ca. 20 mg l(-1)...
- Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activityPatricia Giraldo
Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia CNB CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
Nucleic Acids Res 31:6290-305. 2003....
- Development of electrochemical biosensor based on tyrosinase immobilized in composite biopolymeric filmSanket Tembe
Department of Chemistry, University of Pune, Ganeshkhind, Pune 411 007, India
Anal Biochem 349:72-7. 2006..The analytical characteristics of this sensor, including linear range, lower detection limit, pH, and storage stability, are described. It has reusability up to 15 cycles and a shelf life of more than 2 months...
- Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino miceJillian C Vanover
Department of Pediatrics, University of Kentucky College of Medicine, The Markey Cancer Center, The Graduate Center for Toxicology, Lexington, KY, USA
Pigment Cell Melanoma Res 22:827-38. 2009..These findings suggest that c-kit signaling can overcome the c2j Tyr mutation in the ears and tails of aging animals and that UV resistance depends on accumulation of epidermal eumelanin...
- Additive effects of heat and p38 MAPK inhibitor treatment on melanin synthesisDong Seok Kim
Department of Medicine, College of Medicine, Chung Ang University, Seoul 156 756, Korea
Arch Pharm Res 30:581-6. 2007..We conclude that ERK activation and p38 MAPK inhibition can work in an additive manner to decrease melanogenesis...
- Costs of resistance: genetic correlations and potential trade-offs in an insect immune systemS C Cotter
Institute of Biological Sciences, University of Stirling, Stirling, UK
J Evol Biol 17:421-9. 2004..We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection...
- Oculocutaneous albinism type 1: the last 100 yearsWilliam S Oetting
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Pigment Cell Res 16:307-11. 2003..Though much of the research in albinism has involved OCA1, there are many unanswered questions about OCA1 and albinism, in general. The next 100 yr should still provide many surprises as did the first 100 yr...
- Inulavosin, a melanogenesis inhibitor, leads to mistargeting of tyrosinase to lysosomes and accelerates its degradationHideaki Fujita
Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
J Invest Dermatol 129:1489-99. 2009..Taken together, inulavosin inhibits melanogenesis as a result of mistargeting of tyrosinase to lysosomes...
- A dual mechanism of 4-hydroxy-5-methyl-3[2H]-furanone inhibiting cellular melanogenesisHyo Jung Kim
Department of Molecular Medicine, Kyungpook National University School of Medicine, Daegu, 700 422, Republic of Korea
J Cosmet Sci 59:117-25. 2008..Therefore, the antimelanogenic effects of HMF were best explained by a dual mechanism inhibiting tyrosinase gene expression and the enzyme activity of pre-existing tyrosinase...
- Interactions between environmental variables determine immunity in the Indian meal moth Plodia interpunctellaAlison Triggs
School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
J Anim Ecol 81:386-94. 2012..7. Predictions of the effect of environmental or population change on immunity and disease dynamics based on laboratory experiments that only investigate the effects of single variable are likely to be inaccurate or even entirely wrong...
- Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivoTakeshi Kobayashi
Department of Physiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
J Cell Sci 120:4261-8. 2007..Taken together, these data demonstrate that Tyrp1 interacts directly with Tyr in vivo, which may regulate the stability and trafficking of melanogenic enzymes and thus pigment synthesis...
- Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locusB S Kwon
Molecular Genetics Laboratory, Guthrie Research Institute, Sayre, PA 18840
Proc Natl Acad Sci U S A 84:7473-7. 1987..Southern blot analysis of DNA derived from newborn mice carrying lethal albino deletion mutations revealed that Pmel34 maps near or at the c-albino locus, the position of the structural gene for tyrosinase...
- Cross-linking and immobilisation of different proteins with recombinant Verrucomicrobium spinosum tyrosinaseMichael Fairhead
Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Biomaterials, Lerchenfeldstrasse 5, St Gallen, CH 9014, Switzerland
J Biotechnol 150:546-51. 2010..The resulting aggregates can be collected by centrifugation and retain high levels of activity and may find applications in biocatalysis...
- Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune responsePicheng Zhao
Department of Entomology and Plant Pathology, Oklahoma State University, 127 NRC, Stillwater, OK 74078, USA
Insect Biochem Mol Biol 41:645-52. 2011..Taken together, these data showed that proPO activation and DHI production is strongly toxic against various pathogens but can also damage host tissues and cells if not properly controlled...
- Autosomal albino chicken mutation (ca/ca) deletes hexanucleotide (-deltaGACTGG817) at a copper-binding site of the tyrosinase geneT Tobita-Teramoto
Department of Biology, Keio University, Hiyoshi, Yokohama, Japan
Poult Sci 79:46-50. 2000..We speculate that the six-base deletion is responsible for the inactive tyrosinase in this line of albino chickens...
- The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytesFabien Murisier
Swiss Institute for Experimental Cancer Research ISREC, National Center of Competence in Research NCCR Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Pigment Cell Res 20:173-84. 2007..The results suggest that Sox10 directly, and Mitf, most likely indirectly, activate the tyrosinase enhancer, underlining the contribution of Sox10 to tyrosinase gene regulation in melanocytes...
- MOLECULAR BASIS FOR SCHISTOSOME REPRODUCTIVE DEVELOPMENTPhilip Loverde; Fiscal Year: 1991..A well characterized eggshell gene will serve as a model. 4) Once the DNA elements that control gene expression are identified, attempts to identify the regulatory factors and the genes that encode them will be made...
- 2003 Conference Pan-American Society Pigment Cell ReseaRuth Halaban; Fiscal Year: 2003..3. To provide partial support to students and junior faculty to attend the meeting. They request funds for the 2003 meeting as well as for the 2 subsequent PASPCR annual meetings in years 2004 and 2006. ..
- PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTESRuth Halaban; Fiscal Year: 2004..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
- Epigenetic Chromatin Changes as Melanoma MarkersRuth Halaban; Fiscal Year: 2006..Altogether, the results are likely to generate a novel marker(s) that can be used to assess propensity for malignant transformation, tumor progression and/or sensitivity to chemotherapeutic drugs that target chromatin conformation. ..
- Multi-peptide Vaccine Administered with Cyclophosphamide for High-risk MelanomaCRAIG LEE SLINGLUFF; Fiscal Year: 2010....
- Feline Model of an Inherited Craniofacial AbnormalityLeslie Lyons; Fiscal Year: 2004..Once identified, mutation analyses of these genes in the cat or other species will lead to understanding the genetics of facial development in humans. ..
- GENETIC RESOURCES FOR NON-HUMAN PRIMATESLeslie Lyons; Fiscal Year: 2007..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
- VACCINES WITH MHC CLASS II-RESTRICTED MELANOMA PEPTIDESCraig Slingluff; Fiscal Year: 2004....
- MULTI-EPITOPE MELANOMA VACCINES FOR CD4 AND CD8 T-CELLSCraig Slingluff; Fiscal Year: 2009....
- MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGGWILLIAM JEFFERY; Fiscal Year: 2002..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
- MULTI-EPITOPE MELANOMA PEPTIDE VACCINATION WITH GM-CSFCraig Slingluff; Fiscal Year: 2004..abstract_text> ..
- Role of Prostaglandins & Phospholipase A in melanocytesGlynis Scott; Fiscal Year: 2009..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
- Targeted Molecular Therapeutics for Melanoma: CCI-779 and BevacizumabCraig Slingluff; Fiscal Year: 2008..The following proposal is a clinical trial to evaluate the effects of bevacizumab and CCI-779, which interfere with vascularization and tumor growth, for the treatment of melanoma. [unreadable] [unreadable] [unreadable]..
- Molecular Neurobiology of Drug AbuseDONALD KUHN; Fiscal Year: 2006..Kuhn will remain extensively engaged in scientific mentoring activities. ..
- Trace Element Metabolism: Basic and Applied ResearchMICHAEL PETRIS; Fiscal Year: 2006..These individuals will be encouraged to present posters to be displayed in 2 poster sessions. We also will obtain funds to provide travel awards for up to 10 postdocs or senior graduate students. [unreadable] [unreadable] [unreadable]..
- AFP-Based Immunotherapy for Hepatocellular CarcinomaAntoni Ribas; Fiscal Year: 2006..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
- Complement inhibition in experimental autoimmune uveitisRUSSELL READ; Fiscal Year: 2006..abstract_text> ..
- Antigenic determinants on HLA-B7 and-A2VICTOR ENGELHARD; Fiscal Year: 2006..Collectively, these studies will continue to use mass spectrometry to offer insight into the display of peptides by MHC molecules of cancer cells, and the relevance of this display to control of tumors by the immune system. ..
- Bromelain Proteinase Activity in IBDLAURA HALE; Fiscal Year: 2006..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Regulation of Mammalian Copper HomeotasisMICHAEL PETRIS; Fiscal Year: 2007..The implication of copper in Alzheimer's disease, prion diseases, and several genetic disorders, suggests the study of hCtr1 may have far-reaching implications for the improvement of human health. ..
- Two-Photon Microscopy for Biomedical ResearchBENJAMIN REESE; Fiscal Year: 2007..Acquisition of this 2-photon microscope will therefore enhance the diverse efforts of a number of investigators at UCSB in pursuit of their NIH-funded research objectives. [unreadable] [unreadable] [unreadable]..
- A tyrosinase-targeted drug design for the treatment of melanomaMajid Moridani; Fiscal Year: 2007..In this work we will be developing novel phenol based drugs for treatment of melanoma. [unreadable] [unreadable] [unreadable]..
- Dispersion Patterns for Retinal NeuroblastsBENJAMIN REESE; Fiscal Year: 2009..abstract_text> ..
- Function of Laccases in Anopheles gambiaeMichael R Kanost; Fiscal Year: 2010..Disrupting laccase function may provide a new mechanism for controlling mosquito populations. ..
- Chemoprevention of IBD-Associated Colon CancerLaura P Hale; Fiscal Year: 2010..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
- Altered CD8+ T cell Compartment in SLE PatientsJACQUES F BANCHEREAU; Fiscal Year: 2010..These studies will help us conclude whether killer CD8+T cells and/or suppressor CD8+ T cells i) can be used as markers and/or predictors of disease activity, ii) represent a valuable new option in lupus therapy. ..
- PROTEINASE SYSTEMS IN INSECT HEMOLYMPHMichael R Kanost; Fiscal Year: 2010..sexta, to apply this knowledge to insect vectors of human diseases, and to apply advantages of the M. sexta system for fundamental studies on the regulation of serine protease activity. ..
- Regulation of Mammalian Copper HomeostasisMICHAEL PETRIS; Fiscal Year: 2008..This research will shed light on the importance of copper in the pathogenesis of Alzheimer's disease, and whether the availability of this nutrient should be investigated in therapeutic strategies. ..
- Mast Cells and IBD PathogenesisLAURA HALE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Genetic networks that regulate the mast lineageClifford Takemoto; Fiscal Year: 2009..This proposal will provide insights into the mechanisms of lineage-selection during mast cell development and may lead to therapeutic targets for mast cell-related diseases. ..
- B7-DC Cross-linking antibody immunotherapySvetomir Markovic; Fiscal Year: 2008..If successful, this "proof-of-principle" clinical trial will justify further development of B7-DC XAb as a cancer therapeutic with potential universal application for all malignant disorders. [unreadable] [unreadable] [unreadable]..
- SUBPOPULATIONS OF HUMAN DENDRITIC CELLSJacques Banchereau; Fiscal Year: 2008..unreadable] [unreadable]..
- 19th International Pigment Cell Conference - 2005Zalfa Abdel Malek; Fiscal Year: 2005..abstract_text> ..
- Novel Oral Adjuvant for Dental VaccinesLAURA HALE; Fiscal Year: 2005..abstract_text> ..
- Bromelain as a Biologically-Based Therapy for IBDLAURA HALE; Fiscal Year: 2005..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
- 2004 National Vitiligo Foundation Scientific ConferenceRaymond Boissy; Fiscal Year: 2004..In addition, mini-symposiums will be organized for each of the sessions. ..
- Fine Needle Aspiration Biopsy(FNAB) Needle DeviceVinod Shidham; Fiscal Year: 2002..Apart from the worldwide market, the potential market in United States alone should exceed $1,500,000 per year. ..
- Dendritic Cells, Heat Shock Proteins and Tumor ImmunityJacques Banchereau; Fiscal Year: 2004..These studies will permit us to produce an altered melanoma cell line, with enhanced immunogenicity, that will be used to generate tumor cell bodies to load onto DCs for vaccination protocols. ..
- IDENTIFICATION OF HUMAN MINOR H ANTIGEN PEPTIDES & GENESVICTOR ENGELHARD; Fiscal Year: 2003..abstract_text> ..
- REACTIVE OXYGEN SPECIES AND DROSOPHILA IMMUNITYA Nappi; Fiscal Year: 2001..abstract_text> ..
- MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONEErcole Cavalieri; Fiscal Year: 2003..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
- CATECHOLAMINES AND DEVELOPMENTSuzanne Roffler Tarlov; Fiscal Year: 2002..They will test the hypothesis that norepinephrine induces the differentiation factor that directs the switch from an adrenergic to a cholinergic phenotype in sympathetically-innervated sweat glands. ..
- PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKINRaymond Boissy; Fiscal Year: 2002....
- MICROARRAY ANALYSIS OF HUMAN COCAINE ADDICTSDONALD KUHN; Fiscal Year: 2002..Microarray-based scanning of the human genome has the potential to establish those genes or gene clusters that define the addictive phenotype, leading the way to proteomic-based studies of the bases of addiction. ..
- Dendritic Cell Vaccine in Metastatic Prostate CancerJacques Banchereau; Fiscal Year: 2002..This study will permit us to establish the safety and tolerability of DCs loaded with killed allogeneic tumor cells as a source of TAA. It will also permit us to gain insights into the level of prostate cancer immunity induced by DCs. ..
- Molecular Orgin Cancer--Catechol Estrogen 3 4 QuinonesErcole Cavalieri; Fiscal Year: 2004..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
- Pilot Studies in Biochemistry of Anopheles gambiaeMichael Kanost; Fiscal Year: 2005..gambiae serpins and laccases. This project will be a start toward development of a new research area for the PI (mosquito biochemistry) that will build from his experience in biochemistry of other groups of insects. ..
- Virulence Factor Trafficking in CryptococcusPeter Williamson; Fiscal Year: 2005..Each of the mutants identified in Specific Aims 2 and 3 will then be assessed for production of other virulence-related factors such as capsule, urease, phospholipase and virulence in a mouse model. ..
- Spatial Relationships Between Neurons in the CNSBENJAMIN REESE; Fiscal Year: 2005..abstract_text> ..
- CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAPMark Shriver; Fiscal Year: 2006..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. [unreadable] [unreadable] [unreadable]..
- ROLE OF THE PTEN PATHWAY IN MELANOMAMarcus Bosenberg; Fiscal Year: 2005..He has also completed Ph.D. training in cell biology. The proposed research will be carried out in the laboratory of Dr. Ronald DePinho at the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School. ..
- Mice with Human Dendritic Cells to Test Vaccine PotencyA Palucka; Fiscal Year: 2004..The experiments proposed here would lay ground for further use of SCID-hu/DCs mice to study other vaccines and demonstrate development of protective immunity upon in vivo rechallenge. ..
- Dendritic Cells and Breast Cancer ImmunityA Palucka; Fiscal Year: 2004..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
- NEUROSCIENCE TRAINING IN DRUG ABUSEDONALD KUHN; Fiscal Year: 2004..abstract_text> ..
- Albinism: Defects in Tyrosinase, Amines, or MelaninSuzanne Roffler Tarlov; Fiscal Year: 2005..Ultimately, if such signals deriving from tyrosinase-driven pathway unrelated to melanin production, are found, this research will open doors to therapeutic intervention in individuals carrying the OA1 gene. ..
- Gene Polymorphisms and Kidney Transplant OutcomeWilliam Oetting; Fiscal Year: 2005..abstract_text> ..
- HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIAJeffrey Weber; Fiscal Year: 2003..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
- Dendritic Cell Vaccination During Lymphoid ReconstitutionJeffrey Weber; Fiscal Year: 2008..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
- Genetic Modulation of Noise Injury to the Cochlear Lateral WallKEVIN OHLEMILLER; Fiscal Year: 2009..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
- CTLA-4 Inhibition and Autoimmunity in MelanomaJeffrey Weber; Fiscal Year: 2008..abstract_text> ..
- IL-12 as an Adjuvant for a Melanoma Peptide VaccineJeffrey Weber; Fiscal Year: 2003..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
- Genetic Modulation of Noise Injury to the Cochlear Lateral WallKEVIN OHLEMILLER; Fiscal Year: 2007..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
- COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIESKEVIN OHLEMILLER; Fiscal Year: 2003..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
- IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMAJeffrey Weber; Fiscal Year: 2003....
- Role of CRH in skin physiology and pathologyAndrzej Slominski; Fiscal Year: 2004..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..