monoamine oxidase

Summary

Summary: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.

Top Publications

  1. ncbi Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury
    Pascale Bianchi
    INSERM U388, 31432 Toulouse Cedex 4, France
    Circulation 112:3297-305. 2005
  2. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
  3. pmc Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
    Annika Vaarmann
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    J Biol Chem 285:25018-23. 2010
  4. pmc cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties
    A W Bach
    Center for Molecular Biology, University of Heidelberg, F R G
    Proc Natl Acad Sci U S A 85:4934-8. 1988
  5. ncbi Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors
    Julia K Pinsonneault
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
    Hum Mol Genet 15:2636-49. 2006
  6. pmc Monoamine oxidase: from genes to behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Annu Rev Neurosci 22:197-217. 1999
  7. pmc Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation
    Rong Gu
    Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
    PLoS ONE 6:e14633. 2011
  8. ncbi A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE 171 76, Stockholm, Sweden
    J Psychiatr Res 34:239-44. 2000
  9. ncbi Monoamine oxidase inhibition by Rhodiola rosea L. roots
    Daphne van Diermen
    Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    J Ethnopharmacol 122:397-401. 2009
  10. ncbi Aggression, digit ratio and variation in androgen receptor and monoamine oxidase a genes in men
    Peter L Hurd
    Department of Psychology, University of Alberta, Edmonton, AB, T6G 2E9, Canada
    Behav Genet 41:543-56. 2011

Detail Information

Publications376 found, 100 shown here

  1. ncbi Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury
    Pascale Bianchi
    INSERM U388, 31432 Toulouse Cedex 4, France
    Circulation 112:3297-305. 2005
    ..5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A)...
  2. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment...
  3. pmc Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
    Annika Vaarmann
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    J Biol Chem 285:25018-23. 2010
    ..We demonstrate that the calcium signal is initiated by the metabolism of dopamine by monoamine oxidase, which produces reactive oxygen species and induces lipid peroxidation...
  4. pmc cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties
    A W Bach
    Center for Molecular Biology, University of Heidelberg, F R G
    Proc Natl Acad Sci U S A 85:4934-8. 1988
    ..from three sequenced peptide fragments, we have isolated cDNA clones that encode the A and B forms of monoamine oxidase and have determined the nucleotide sequences of these cDNAs...
  5. ncbi Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors
    Julia K Pinsonneault
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
    Hum Mol Genet 15:2636-49. 2006
    ..Therefore, allelic mRNA expression is affected by genetic and epigenetic events, both with the potential to modulate biogenic amine tone in the CNS...
  6. pmc Monoamine oxidase: from genes to behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Annu Rev Neurosci 22:197-217. 1999
    Cloning of MAO (monoamine oxidase) A and B has demonstrated unequivocally that these enzymes are made up of different polypeptides, and our understanding of MAO structure, regulation, and function has been significantly advanced by ..
  7. pmc Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation
    Rong Gu
    Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
    PLoS ONE 6:e14633. 2011
    ..Here, we identify a potential mechanism underlying norepinephrine accumulation in a rat model of heart failure...
  8. ncbi A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE 171 76, Stockholm, Sweden
    J Psychiatr Res 34:239-44. 2000
    ..We investigated possible relationships between a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene and CSF concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-..
  9. ncbi Monoamine oxidase inhibition by Rhodiola rosea L. roots
    Daphne van Diermen
    Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    J Ethnopharmacol 122:397-401. 2009
    ..In order to investigate the influence of Rhodiola rosea L. roots on mood disorders, three extracts were tested against monoamine oxidases (MAOs A and B) in a microtitre plate bioassay...
  10. ncbi Aggression, digit ratio and variation in androgen receptor and monoamine oxidase a genes in men
    Peter L Hurd
    Department of Psychology, University of Alberta, Edmonton, AB, T6G 2E9, Canada
    Behav Genet 41:543-56. 2011
    ....
  11. ncbi Structure and mechanism of monoamine oxidase
    D E Edmondson
    Department of Biochemistry and Chemistry, Emory University, Atlanta, Georgia 30322, USA
    Curr Med Chem 11:1983-93. 2004
    ..The existing structural data on MAO B support previous QSAR results and are also supportive of a proposed polar nucleophilic mechanism for MAO A and B catalysis rather than the alternatively proposed single electron transfer mechanism...
  12. pmc Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
    Jianchao Xu
    Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 115:1275-80. 2005
    ..These results identify renalase as what we believe to be a novel amine oxidase that is secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure...
  13. ncbi Renalase, hypertension, and kidney - the discussion continues
    Jolanta Malyszko
    Department of Nephrology and Transplantology, Medical University in Bialystok, Bialystok, Poland
    Angiology 64:181-7. 2013
    ..Renalase is "a new postulated therapeutic target." Proof of concept studies are needed to define the pathophysiological link between the kidney, sympathetic tone, BP, and cardiovascular complications...
  14. ncbi Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre and Mood and Anxiety Disorders Division, Clarke Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 63:1209-16. 2006
    ..b>Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.
  15. pmc A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study
    Ramin Farzaneh-Far
    Division of Cardiology, San Francisco General Hospital, San Francisco, California, United States of America
    PLoS ONE 5:e13496. 2010
    ..The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported...
  16. ncbi Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
    J W Buckholtz
    Neuroimaging Core Facility, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1365, USA
    Mol Psychiatry 13:313-24. 2008
    ..To identify these circuits, we used a combined genetic and imaging approach focused on Monoamine Oxidase A (MAOA), encoding a key enzyme for monoamine metabolism previously associated with temperament and ..
  17. ncbi Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period
    O Cases
    Centre National de la Recherche Scientifique, Institut Curie, Orsay France
    Neuron 16:297-307. 1996
    In a transgenic mouse line (Tg8) deficient for the gene encoding monoamine oxidase A (MAOA), we show that the primary somatosensory cortex (S1) lacks the characteristic barrel-like clustering of layer IV neurons, whereas normal pattern ..
  18. ncbi Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..We examined polymorphisms in genes encoding the catabolic enzymes catechol-O-methyltransferase and monoamine oxidase A...
  19. pmc Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload
    Nina Kaludercic
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circ Res 106:193-202. 2010
    ..Because excess reactive oxygen species and catecholamines are major contributors to the pathophysiology of congestive heart failure, MAOs could play an important role in this process...
  20. pmc MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma
    Natalie Weder
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 65:417-24. 2009
    Childhood adversity has been shown to interact with monoamine oxidase-A (MAOA) genotype to confer risk for antisocial behavior. Studies examining this gene-by-environment (G x E) association, however, have produced mixed results.
  21. ncbi The therapeutic potential of monoamine oxidase inhibitors
    Moussa B H Youdim
    Technion Rappaport Family Faculty of Medicine, Eve Topf and US National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases
    Nat Rev Neurosci 7:295-309. 2006
    b>Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such...
  22. pmc The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B
    L P Quinn
    Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK
    Br J Pharmacol 154:226-33. 2008
    ....
  23. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species...
  24. ncbi Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition
    H K Wayment
    Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
    J Neurosci 21:35-44. 2001
    ....
  25. pmc Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation
    Jean Marie Launay
    Service de Biochimie et Biologie Moléculaire Equipe Associée EA 3621, Assistance Publique des Hopitaux de Paris, Hopital Lariboisiere, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    PLoS ONE 4:e7959. 2009
    ....
  26. ncbi Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase
    Fabio Di Lisa
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Basic Res Cardiol 104:131-9. 2009
    ..Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis...
  27. ncbi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD...
  28. ncbi Hyperserotonergic phenotype after monoamine oxidase inhibition in larval zebrafish
    Ville Sallinen
    Neuroscience Center, Institute of Biomedicine Anatomy, University of Helsinki, Finland
    J Neurochem 109:403-15. 2009
    Serotonin (or 5-hydroxytryptamine; 5-HT) and monoamine oxidase (MAO) are involved in several physiological functions and pathological conditions...
  29. ncbi (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties
    Kálmán Magyar
    Department of Pharmacodynamics, Neurochemical Research Unit, Semmelweis University, Hungarian Academy of Sciences, PO Box 370, Budapest 1445, Hungary
    Neurotoxicology 25:233-42. 2004
    Deprenyl (selegiline) is an irreversible inhibitor of monoamine oxidase (MAO) B, which was discovered in 1962 and become the "golden standard" of MAO research...
  30. ncbi Current place of monoamine oxidase inhibitors in the treatment of depression
    Kenneth I Shulman
    Professor, Department of Psychiatry, Faculty of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada
    CNS Drugs 27:789-97. 2013
    This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as phenelzine, tranylcypromine and isocarboxazid, as well as the second generation selective and reversible MAOIs ..
  31. ncbi Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins
    Min Li
    Department of Biochemistry, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Biochemistry 45:4775-84. 2006
    ..These results are consistent with a proposed polar nucleophilic mechanism for catalytic amine oxidation...
  32. pmc Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline
    Zaid A Abassi
    Department of Physiology and Biophysics, Technion Rappaport Faculty of Medicine and Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, Israel
    Br J Pharmacol 143:371-8. 2004
    ..l-methamphetamine and aminoindan (TVP-136), respectively, and the second rasagiline metabolite non-monoamine oxidase (MAO) inhibitor TVP-1022 (N-propargyl-1S(-)aminoindan). Intravenous (i.v...
  33. ncbi The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution
    Kate E Atkin
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    J Mol Biol 384:1218-31. 2008
    b>Monoamine oxidase from Aspergillus niger (MAO-N) is a flavoenzyme that catalyses the oxidative deamination of primary amines...
  34. ncbi Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di
    Irene Bolea
    Departament de Bioquı́mica i Biologı́a Molecular, Facultat de Medicina, Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Med Chem 54:8251-70. 2011
    ..Overall, the results suggest that the new compounds are promising multitarget drug candidates with potential impact for Alzheimer's disease therapy...
  35. pmc The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates
    Ann R Holmes
    Sir John Walsh Research Institute and Department of Oral Sciences, University of Otago, Dunedin, New Zealand
    Antimicrob Agents Chemother 56:1508-15. 2012
    ..Nine compounds were identified as hits, and the monoamine oxidase A inhibitor (MAOI) clorgyline was identified as an inhibitor of two C...
  36. ncbi Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer's disease but not in non-demented Parkinson's disease patients
    Maria Zellner
    Surgical Research Laboratories, Medical University of Vienna, Austria
    J Proteomics 75:2080-92. 2012
    b>Monoamine oxidase-B (Mao-B) catalysing the breakdown of the neurotransmitter dopamine, is known to be involved in the pathophysiology of Parkinson's (PD) and Alzheimer's disease (AD). Increased brain Mao-B activity is associated with AD...
  37. pmc Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression
    Matthew Grunewald
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Biol Chem 287:24195-206. 2012
    ..illnesses, including depressive disorders, and is characterized by increased blood glucocorticoids and brain monoamine oxidase A (MAO A, which degrades monoamine neurotransmitters)...
  38. ncbi Abnormal function of monoamine oxidase-A in comorbid major depressive disorder and cardiovascular disease: pathophysiological and therapeutic implications (review)
    Rodrigo Machado-Vieira
    Laboratory of Neuroscience, LIM27, Institute and Department of Psychiatry, University of Sao Paulo, SP, Brazil
    Mol Med Rep 6:915-22. 2012
    ..However, the enzyme monoamine oxidase-A (MAO-A), which has a key role in the degradation of catecholamines, has been associated ..
  39. ncbi Human renalase: a review of its biology, function, and implications for hypertension
    Gary V Desir
    Medical Service, VA Connecticut Healthcare System, West Haven, CT, USA
    J Am Soc Hypertens 6:417-26. 2012
    ....
  40. ncbi Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and ..
  41. ncbi Is renalase a novel player in catecholaminergic signaling? The mystery of the catalytic activity of an intriguing new flavoenzyme
    Sara Baroni
    Dipartimento di Bioscienze, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Curr Pharm Des 19:2540-51. 2013
    ....
  42. ncbi Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
    Timothy K Newman
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Biol Psychiatry 57:167-72. 2005
    Allelic variation of the monoamine oxidase A (MAOA) gene has been implicated in conduct disorder and antisocial, aggressive behavior in humans when associated with early adverse experiences...
  43. pmc Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts
    Nina Kaludercic
    1 Neuroscience Institute, National Research Council of Italy, Padova, Italy
    Antioxid Redox Signal 20:267-80. 2014
    ..The potential pathogenetic role of the isoenzyme MAO-B in cardiac diseases is currently unknown. Moreover, it is has not been determined yet whether MAO activation can directly affect mitochondrial function...
  44. ncbi Berberine: a potential multipotent natural product to combat Alzheimer's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Molecules 16:6732-40. 2011
    ..activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and cholesterol-lowering activities, which suggest that ..
  45. ncbi Mitochondria and vascular pathology
    Fabio Di Lisa
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Pharmacol Rep 61:123-30. 2009
    ..e., diabetes, hyperlipidemia, hypertension) associated with atherosclerosis...
  46. pmc Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats
    B Meyers
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    Neuroscience 165:850-62. 2010
    ..of these systems could be related to gonadal steroid effects on catechol-O-methyltransferase and monoamine oxidase which are principal enzymatic controllers of forebrain dopamine, serotonin and norepinephrine levels...
  47. pmc Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 518, Los Angeles, CA 90089, USA
    Mol Pharmacol 79:308-17. 2011
    ..Together, this study uncovers for the first time the molecular mechanisms for glucocorticoid activation of MAO B gene and provides new insights into the hormonal regulation of MAO...
  48. pmc Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids
    I Thiblin
    Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden
    Br J Pharmacol 126:1301-6. 1999
    ..Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2...
  49. ncbi The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    K Castagnoli
    Department of Chemistry, Virginia Tech, Blacksburg 24061 0212, USA
    Chem Res Toxicol 10:364-8. 1997
    ..MPTP) are thought to result from inhibition of complex I of the mitochondrial respiratory chain by the monoamine oxidase-B (MAO-B) generated 1-methyl-4-phenylpyridinium metabolite MPP+...
  50. pmc Retinoic acid activates monoamine oxidase B promoter in human neuronal cells
    Jason B Wu
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:16723-35. 2009
    b>Monoamine oxidase (MAO) B deaminates a number of biogenic and dietary amines and plays an important role in many biological processes...
  51. pmc Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder
    Steven R H Beach
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    J Fam Psychol 24:12-20. 2010
    There is a growing body of data indicating that Gene x Child Maltreatment interactions at monoamine oxidase A (MAOA) play a role in vulnerability to symptoms of antisocial personality disorder (ASPD) but not major depression (MD)...
  52. pmc Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women
    Erin L Kinnally
    Department of Molecular Imaging and Neuropathology, Columbia University, New York, USA
    Psychiatr Genet 19:126-33. 2009
    ..A functional polymorphism in the regulatory region of the monoamine oxidase A gene (monoamine oxidase A untranslated variable nucleotide tandem repeat, MAOA-uVNTR) may moderate the ..
  53. pmc Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation
    Jason Boyang Wu
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    Mol Pharmacol 80:714-23. 2011
    ..Here, we report for the first time that VPA activates monoamine oxidase (MAO) A catalytic activity, mRNA level, and promoter activity...
  54. ncbi Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors
    Tomas Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006, Madrid, Spain
    Biochem Biophys Res Commun 326:378-86. 2005
    b>Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines, and a well-known target for ..
  55. ncbi Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A
    Ema Alves
    Grupo Neurocomportamento, Instituto de Biologia Molecular e Celular IBMC, University of Porto UP, Porto, Portugal
    Addict Biol 14:185-93. 2009
    ..Although these toxic effects were shown to be prevented by monoamine oxidase B inhibition, the role of monoamine oxidase A (MAO-A) in MDMA-mediated mitochondrial damage remains to be ..
  56. ncbi Serum renalase depends on kidney function but not on blood pressure in heart transplant recipients
    P Przybylowski
    Cardiovascular Surgery and Transplantology, Collegium Medicum, Jagiellonian University, John Paul II Hospital, Krakow, Poland
    Transplant Proc 43:3888-91. 2011
    ..To obtain normal ranges we also studied renalase levels in 27 healthy volunteers...
  57. ncbi Family-based association study between the monoamine oxidase A gene and obesity: implications for psychopharmacogenetic studies
    Beatriz Camarena
    Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente México DF, Mexico DF, Mexico
    Neuropsychobiology 49:126-9. 2004
    ..We investigated the association between the monoamine oxidase A (MAO-A) gene and obesity. Fifty obese subjects and their parents were included in the study...
  58. pmc Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
    Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression...
  59. pmc Regulation of monoamine oxidase A by the SRY gene on the Y chromosome
    Jason B Wu
    Department of Pharmacology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, PSC 518, Los Angeles, CA 90089 9121, USA
    FASEB J 23:4029-38. 2009
    b>Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions...
  60. ncbi The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased β-amyloid(1-40) peptide and TNF-α contents, and susceptibility of mitochondria t
    Marcos Roberto de Oliveira
    Centro de Estudos em Estresse Oxidativo Lab 32, Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Brain Res Bull 87:432-44. 2012
    ..mitochondrial redox state (both oxidative and nitrosative stress markers), electron transfer chain activity, monoamine oxidase (MAO) enzyme activity, endoplasmic reticulum stress marker (BiP), α- and β-synucleins, β-amyloid peptide (..
  61. ncbi Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: achievements and unsolved problems
    A E Medvedev
    Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russia
    Biochemistry (Mosc) 75:951-8. 2010
    ....
  62. ncbi Synthesis of human renalase1 in Escherichia coli and its purification as a FAD-containing holoprotein
    Vittorio Pandini
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Protein Expr Purif 72:244-53. 2010
    ..The procedures for the production and isolation of recombinant renalase1 here reported are expected to boost the much awaited biochemical studies on this remarkable protein...
  63. ncbi New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity
    Nesrin Gökhan-Kelekçi
    Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Sihhiye, Ankara, Turkey
    Bioorg Med Chem 17:675-89. 2009
    ..The very high MAO-B selectivity for 4i can be also explained in terms of the distance between the FAD and the compound, which was greater in the complex of MAO-A-4i as compared to the corresponding MAO-B complex...
  64. ncbi Renalase, a novel regulator of blood pressure, is predicted by kidney function in renal transplant recipients
    J Malyszko
    Department of Nephrology and Transplantology, Medical University, Bialystok, Poland
    Transplant Proc 43:3004-7. 2011
    ..The human kidney releases this protein into the bloodstream to regulate blood pressure. In kidney transplant recipients, the prevalence of hypertension is 60%-80%...
  65. ncbi Bioelectronic detector with monoamine oxidase for halitosis monitoring
    T Minamide
    Graduate School of Engineering, Tokai University, Hiratsuka, Japan
    Analyst 130:1490-4. 2005
    ..The bio-detector consisted of a Clark-type dissolved oxygen electrode, a monoamine oxidase type-A (MAO-A) immobilized membrane and a reaction unit that had liquid and gaseous compartments separated ..
  66. pmc Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures
    Claudia Binda
    Department of Genetics and Microbiology, University of Pavia, Via Abbiategrasso, 27100 Pavia, Italy
    Proc Natl Acad Sci U S A 100:9750-5. 2003
    b>Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound enzyme that catalyzes the oxidative deamination of arylalkylamine neurotransmitters and has been a target for a number of clinically used drug inhibitors. The 1...
  67. ncbi MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder
    Ana P Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Neuropsychopharmacol 12:709-14. 2009
    The monoamine oxidase A (MAOA) gene has been extensively related to aggressive, impulsive and violent behaviours...
  68. pmc Targeting monoamine oxidase A in advanced prostate cancer
    Vincent Flamand
    Department of Urology, Stanford Medical Center, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
    J Cancer Res Clin Oncol 136:1761-71. 2010
    Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression...
  69. pmc Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke
    Monika Buraczynska
    Laboratory for DNA Analysis and Molecular Diagnostics, Department of Nephrology, Medical University of Lublin, Dr K Jaczewskiego 8, 20 954, Lublin, Poland
    Neuromolecular Med 13:321-7. 2011
    ..The G allele of this polymorphism might thus be useful in identifying diabetes patients at increased risk of stroke...
  70. ncbi Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors
    Tomas Herraiz
    Instituto de Ciencia y Tecnología de Alimentos y Nutrición ICTAN, Spanish Council for Scientific Research CSIC, Juan de la Cierva, Madrid, Spain
    Food Chem Toxicol 49:1773-81. 2011
    b>Monoamine oxidase (MAO) enzymes located in human mitochondria oxidize neurotransmitters and bioactivate the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by oxidation to directly-acting neurotoxic pyridinium cations (..
  71. ncbi Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies
    Claudia Binda
    Dept Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Curr Top Med Chem 11:2788-96. 2011
    ..This multi-target approach may prove successful in order to find new and more effective therapies for the complexity of neurodegenerative diseases...
  72. ncbi The pharmacology of selegiline
    Kálmán Magyar
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Int Rev Neurobiol 100:65-84. 2011
    ..To circumvent the "first pass" metabolism, parenteral administration of the drug might lead to different distribution and pharmacological activity of selegiline...
  73. pmc Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression
    Almas Siddiqui
    Buck Institute for Age Research, Novato, CA 94945, USA
    Neurobiol Dis 40:444-8. 2010
    We previously demonstrated that elevation of astrocytic monoamine oxidase B (MAO-B) levels in a doxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to ..
  74. ncbi Protective effect of green tea (-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains
    Shyh Mirn Lin
    Department of Food and Nutrition, Chung Hwa University of Medical Technology, Taiwan, ROC
    Nutrition 26:1195-200. 2010
    b>Monoamine oxidase B (MAO-B) levels were observed increasing during aging in rat brains. (-)-Epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent in green tea...
  75. ncbi Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice
    A Rajeswari
    Department of Zoology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, South India
    Inflammopharmacology 16:96-9. 2008
    ..In this model depletion of dopamine(DA) and DOPAC (3,4-dihydroxy phenyl acetic acid)) occurs with increased monoamine oxidase (MAO-B) activity...
  76. ncbi Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women
    Aryeh I Herman
    Unit of Clinical and Biochemical Pharmacology, Laboratory of Clinical Studies, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 133:74-8. 2005
    ..Both monoamine oxidase type A (MAOA) and the serotonin transporter protein are involved in the processing of serotonin, and allelic ..
  77. ncbi Novel insights into the physiology of renalase and its role in hypertension and heart disease
    Gary Desir
    Section of Nephrology, Department of Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208029, New Haven, CT 06520 8029, USA
    Pediatr Nephrol 27:719-25. 2012
    ....
  78. pmc A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene
    H Sugino
    Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Japan
    J Bacteriol 174:2485-92. 1992
    The Klebsiella aerogenes gene maoA, which is involved in the synthesis of monoamine oxidase, was induced by tyramine and the related compounds, subjected to catabolite and ammonium ion repression, and cloned...
  79. ncbi Renalase, a novel enzyme involved in blood pressure regulation, is related to kidney function but not to blood pressure in hemodialysis patients
    Edyta Zbroch
    Department of Nephrology and Transplantology, Medical University, Bialystok, Poland
    Kidney Blood Press Res 35:395-9. 2012
    ..The aim of this study was to assess serum renalase levels in hemodialysis patients and their relationship to blood pressure control, type of antihypertensive therapy and the presence of residual renal function...
  80. ncbi MAOA and the neurogenetic architecture of human aggression
    Joshua W Buckholtz
    Vanderbilt Brain Institute and Department of Psychology, Vanderbilt University, Nashville, TN 37212, USA
    Trends Neurosci 31:120-9. 2008
    ..Our construct provides a neurobiologically consistent model for gene-environment interactions in impulsive aggression...
  81. ncbi A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder
    JieXu Zhang
    Institute of Basic Medical Sciences, Tsinghua University, Beijing, China
    Biol Psychiatry 68:795-800. 2010
    ..To better understand the mechanism by which the monoamine oxidase A (MAOA) gene may play a role in developing MDD, the present work examined the cis-phase interaction between ..
  82. ncbi Identification, expression and tissue distribution of a renalase homologue from mouse
    Jian Wang
    Laboratory for Functional Genomic Research, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China
    Mol Biol Rep 35:613-20. 2008
    ..A novel monoamine oxidase, named renalase, has been identified in human kidney recently and is found to be markedly reduced in ..
  83. ncbi Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders
    Blanca Gutierrez
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Psychiatr Genet 14:203-8. 2004
    b>Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and ..
  84. pmc Serotonin, genetic variability, behaviour, and psychiatric disorders--a review
    Niklas Nordquist
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 115:2-10. 2010
    ..Many studies have implicated genetic variability in the genes encoding monoamine oxidase A (MAOA) and the serotonin transporter (5HTT) in modulating susceptibility to these conditions...
  85. ncbi Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease
    Jacobus P Petzer
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom, 2520, South Africa
    Neurotherapeutics 6:141-51. 2009
    ..Inhibitors of monoamine oxidase (MAO)-B also are considered useful tools for the treatment of PD...
  86. ncbi Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats
    Agnes Maurel
    Unité 388, Institut National de la Sante et de la Recherche Medicale, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31403 Toulouse Cedex 04, France
    Am J Physiol Heart Circ Physiol 284:H1460-7. 2003
    ..In the present study, we investigated the role of the catecholamine-degrading enzyme monoamine oxidase (MAO) in H(2)O(2) production in the hearts of young, adult, and old rats...
  87. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality...
  88. ncbi Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme
    Sandro Arguelles
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
    Neurotoxicology 31:55-66. 2010
    ..Dexamethasone increased oxidative stress and expression of monoamine oxidase A and B, along with changes on different MAP kinases related to degenerative processes, resulting in a ..
  89. ncbi Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    This article describes the kinetic modeling of [(11)C]-harmine binding to monoamine oxidase A (MAO-A) binding sites in the human brain using positron emission tomography (PET)...
  90. ncbi Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia
    R J Wyatt
    Science 179:916-8. 1973
    b>Monoamine oxidase activity in blood platelets was measured, with [(14)C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers...
  91. ncbi Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy
    Hailin Zheng
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    ACS Chem Biol 5:603-10. 2010
    ..report a new strategy for designing site-activated chelators targeting both acetylcholinesterase (AChE) and monoamine oxidase (MAO)...
  92. pmc MAOA methylation is associated with nicotine and alcohol dependence in women
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:565-70. 2008
    ..One prominent locus at which epigenetic phenomena are thought to be in play is the monoamine oxidase A (MAOA) locus...
  93. ncbi MAOA gene polymorphisms and response to mirtazapine in major depression
    Dong Sheng Tzeng
    Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan
    Hum Psychopharmacol 24:293-300. 2009
    Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD).
  94. ncbi Catecholamines regulate the activity, secretion, and synthesis of renalase
    Guoyong Li
    Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Circulation 117:1277-82. 2008
    ..Renalase plasma levels are markedly reduced in patients with chronic kidney disease. It is not known whether endogenous renalase contributes to the regulation of catecholamines...
  95. ncbi Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affective disorders...
  96. ncbi Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline
    Tamar Goren
    Teva Pharmaceutical Industries Ltd, PO Box 8077 Kiryat Nordau, Netanya, Israel
    J Clin Pharmacol 50:1420-8. 2010
    Rasagiline is a selective, monoamine oxidase (MAO)-B inhibitor indicated for treatment of Parkinson's disease...
  97. ncbi beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
    T Herraiz
    Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Madrid, Spain
    Food Chem Toxicol 48:839-45. 2010
    ..0% and 1.4% (w/w), respectively. Seed extracts were potent reversible and competitive inhibitors of human monoamine oxidase (MAO-A) with an IC(50) of 27 microg/l whereas root extracts strongly inhibited MAO-A with an IC(50) of 159 ..
  98. ncbi Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline
    A Kupsch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, and Institute of Physiology, Munchen, Federal Republic of Germany
    J Neural Transm 108:985-1009. 2001
    ..It remains to be determined, if this histological observation represents potential adverse effects of high dose treatment with monoamine oxidase inhibitors.
  99. ncbi Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
    We tested for gender-specific interactions between smoking and genetic polymorphisms of monoamine oxidase B (MAO-B) intron 13 (G or A allele), monoamine oxidase A (MAO-A) EcoRV (Yor N allele), and dopamine D2 recepor (DRD2) Taq1B (B1 or ..
  100. ncbi Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
    Highly significant elevations in regional brain monoamine oxidase A (MAO-A) binding were recently reported during major depressive episodes (MDEs) of major depressive disorder (MDD)...
  101. pmc Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    J Neural Transm 116:1323-34. 2009
    b>Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect...

Research Grants66

  1. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..of landmark studies like those by Caspi et al demonstrating how early maltreatment interacts with the monoamine oxidase A genotype to yield antisocial behavior and how the 5-HTT transporter interacts with adverse early adult ..
  2. Epigenetic Regulation of Serotonin:Relevance to HIV and Methamphetamine Abuse
    GREGORY MICHAEL MILLER; Fiscal Year: 2012
    ..genes that encode the key modulators of the serotonin system, including the serotonin transporter (5-HTT), monoamine oxidase A (MAOA) and tryptophan hydroxylase 2 (TPH2) have been well-documented, epigenetic regulation of these genes ..
  3. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..A regulatory mechanism is proposed that could lead to a novel treatment in psychiatric illnesses with explosive rage and impulse disorders. ..
  4. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..In the future, beyond the scope of this proposal, nuclear medicine imaging of brain cell gene activity in humans might explain why some individuals become addicted more easily than others. ..
  5. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..E), neurotransmitter metabolism (dopamine transporter, dopamine D4 receptor, norepinephrine transporter, monoamine oxidase, catechol O-methyltransferase, NMDA receptor, 5-HT1A receptor), and methylation metabolism (..
  6. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    ..Pretreatment with an MAO (monoamine oxidase) inhibitor alone, can decrease cocaine self-administration by more than 60%, but does not cause PA (cocaine ..
  7. Studies toward the development of monoamine oxidase B specific inhibitors
    ERIKA MARIE MILCZEK; Fiscal Year: 2010
    ..HEALTH RELEVANCE The goal of this project is to explore the structure/function relationship of the enzyme, monoamine oxidase B, by identifying amino acid residues responsible for substrate specificity and designing inhibitors that ..
  8. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..This will concentrate initially on monoamine oxidase A (MAOA)...
  9. Interactions of MAO A with vulnerability factors for aggression
    Marco Bortolato; Fiscal Year: 2012
    ..vulnerability factors for pathological aggression: early psychosocial stress;low activity of brain monoamine oxidase (MAO) A, the major enzyme for the degradation of brain serotonin (5-HT), norepinephrine (NE) and dopamine (..
  10. A Program of Research and Mentorship on Alcohol Use and Intimate Partner Violence
    Gregory L Stuart; Fiscal Year: 2013
    ..The proposed K24 award will provide the protected time required to cultivate my knowledge of behavioral genetics research, while allowing me considerable time to mentor an outstanding group of junior colleagues. ..
  11. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This project aims to develop new radiolabeled substrates for the enzyme monoamine oxidase-B (MAO- B) in the human brain...
  12. Ethanol induced brain injury is decreased by inhibiting TIEG2 mediated cell death
    CRAIG ALLEN STOCKMEIER; Fiscal Year: 2013
    ..is a transcription factor that inhibits cell growth, induces apoptosis, and increases the expression of monoamine oxidase B (MAO B)...
  13. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ..between genetic markers from five carefully selected regions - the serotonin transporter gene (SLC6A4), the monoamine oxidase A gene (MAOA), the catechol-O-methyltransferase gene (COMT), the type 4 dopamine receptor gene (DRD4), and a ..
  14. Prenatal Smoke Exposure and Offspring Substance Use: An Imaging-Genetics Approach
    Ardesheer Talati; Fiscal Year: 2013
    ..I will then test the hypothesis that functionally altering variations within the monoamine oxidase A gene (as well as other genes of interest, particularly within the nicotinic and dopaminergic families) ..
  15. Role of Serotonin in Mediating Stress-Induced Infertility
    Judy L Cameron; Fiscal Year: 2013
    ..Cameron, Bethea and Berga represents an unique opportunity to test this potential new therapy for FHA both in an appropriate animal model in which we can examine neural systems, and in a small pilot clinical study. ..
  16. COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
    Mariana Cherner; Fiscal Year: 2010
    ..propose to investigate the role of other dopamine system genes (tyrosine hydroxylase, DOPA decarboxylase, monoamine oxidase A and dopamine receptors D1-4) that may be similarly implicated in functions leading to risky decision-..
  17. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2013
    ..this application is to test the hypothesis that: 1) early developmental stages are critically important for monoamine oxidase (MAO) A to induce long-term effects on neuroplasticity and aggression through the regulation of serotonin (5-..
  18. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia-Klein; Fiscal Year: 2013
    ..Specifically, monoamine oxidase A (MAO A), an enzyme regulating the neurotransmitters serotonin and norepinephrine, has been reliably ..
  19. Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..comparable polymorphisms in rhesus monkey serotonin transporter (SERT), tryptophan hydroxylase 2 (TPH2) and monoamine oxidase A (MAOA) genes, and assess genotype/phenotype relationships relevant to drug addiction, alcoholism and ..
  20. Structure, function and engineering of nuclease catalysts
    Barry L Stoddard; Fiscal Year: 2013
    ..target sites in (i) the human cystic fibrosis-associated chloride transporter (CFTR) gene and (ii) the human monoamine oxidase (MOAB) gene...
  21. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2013
    ..for polymorphisms in the promoter regions of two neuropsychiatric genes, the serotonin transporter and monoamine oxidase-A;c) assessing regulation of the hypothalamic-pituitary-adrenal system;and d) measuring routine hematologic ..
  22. HCV and Pain in Substance Users With and Without HIV
    Judith Tsui; Fiscal Year: 2013
    ....
  23. Inactivation of LSD1 as a possible treatment for sickle cell disease
    James Douglas Engel; Fiscal Year: 2013
    ..One of the modifying enzymes is LSD1, a monoamine oxidase that removes activating chromatin signatures, thereby leading to gene repression...
  24. Epigenetic Status of MAOA Gene as a Module of Translational Behavioral Research
    Elena Shumay; Fiscal Year: 2013
    ..It aims to investigate the mechanisms by which (focus of the proposal is on monoamine oxidase A (MAOA) gene) affect brain function...
  25. Gene x Environment Interactions Predicting an Endophenotype for Depression
    Caroline Oppenheimer; Fiscal Year: 2012
    ..candidate genes: the serotonin transporter gene (5-HTTLPR), the dopamine D2 receptor gene (DRD2), and monoamine oxidase A (MAOA)...
  26. Proteomic Markers of Alcohol Abuse (Phase 1)
    LAWRENCE SNELL; Fiscal Year: 2009
    ..Phase I studies will also provide the initial panel of candidate markers to be assessed in a significantly greater number of subjects in Phase ll. ..
  27. Molecular Imaging of Cancer and Its Response to Therapy
    Kenneth A Krohn; Fiscal Year: 2013
    ..ligands for HER2 as a factor in treating breast cancer, new agents for imaging of androgen biology, a monoamine oxidase A ligand to select patients for a new clinical trial for prostate adenocarcinoma and studies comparing Cu-..
  28. Developing a PET biomarker to predict response in treatment-resistant depression
    PATRICK J MC GRATH; Fiscal Year: 2010
    ..The recent landmark finding of an markedly elevated level of monoamine oxidase A (MAO- A) in the brains of depressed patients with MDD compared to controls, using positron emission ..
  29. NEUROTRANSMITTERS AND VENTILATORY CONTROL
    EARL OLSON; Fiscal Year: 1990
    ..An average-of a) the rate of monoamine buildup after inhibition of monoamine oxidase, and of b) the rate of monoamine breakdown after inhibition of biosynthesis-is the index for monoamine ..
  30. COVALENT FLAVIN COENZYMES IN FLAVOENZYME CATALYSIS
    Dale E Edmondson; Fiscal Year: 2013
    ..studies of the molecular basis for specific inhibitor design for the target enzymes: human mitochondrial Monoamine Oxidase A and B (MAO A and MAO B)...
  31. Expanding the Utility of Social Network Analysis for Multilevel Health Outcomes
    Brenda McCowan; Fiscal Year: 2013
    ....
  32. Antisocial Behavior, Genetics, and the Life Course
    Michael J Shanahan; Fiscal Year: 2010
    ..specific neurogenetic polymorphisms (NPs, measured as haplotypes) associated with dopamine, serotonin, and monoamine oxidase, and indicators of antisocial behavior-- including delinquency, involvement with the criminal justice system,..
  33. G PROTEIN-COUPLED RECEPTOR KINASES
    Jeffrey L Benovic; Fiscal Year: 2013
    ..that: (A) GRK-2 regulates serotonin metabolism by regulating vesicular monoamine transporter and/or monoamine oxidase activity and (B) 5-HIAA functions as a biased SER-1 agonist...
  34. Cumulative Genetic and Environmental Predictors of Youth Substance Use
    JENNIFER LYNN CARRANO; Fiscal Year: 2012
    ..Further, findings will add to what is still a rather sparse and contradictory literature on genetic effects on substance use and will help shed light on discrepant findings regarding gender differences in substance use etiology. ..
  35. Towards High Throughput Proteomics: A Micro/nanofluidic Framework for Blotless W
    AMY ELIZABETH HERR; Fiscal Year: 2013
    ..Further, 2) the principal investigator seeks to validate or invalidate the importance of the enzyme monoamine oxidase-A (MAO-A) in aggressive prostate cancer phenotypes, by using the newly introduced technology to analyze MAO-..
  36. DRUG TREATMENT OF COEXISTING PANIC AND MAJOR DEPRESSION
    ROBERT LYDIARD; Fiscal Year: 1999
    ..medications best documented to be effective in both of these conditions are the tricyclic imipramine and the monoamine oxidase inhibitor phenelzine...
  37. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..Lysyl oxidases are copper-dependent monoamine oxidase enzymes which even today are responsible for the lysine-derived cross-links in collagen and elastin of all ..
  38. MODELS OF PSYCHOBIOLOGICAL DEVELOPMENT
    Martin Reite; Fiscal Year: 1993
    ..Professional development will include formal and informal training in MR imaging and MR spectroscopy theory and techniques. ..
  39. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..The objectives of this project are to understand the[unreadable] regulation and the in-vivo function of monoamine oxidase (MAO) A and B,[unreadable] which are isoenzymes important for the degradation of monoamine[unreadable] ..
  40. BIOLOGY OF GLUTATHIONE PEROXIDASE IN DOPAMINE NEURONS
    Gerald Cohen; Fiscal Year: 1993
    ..peroxide (H2O2) is a neurotoxic agent that is generated during the natural oxidation of dopamine (DA) by monoamine oxidase (MAO)...
  41. Genes, Gendered Contexts, and Substance Use Outcomes
    Edelyn Verona; Fiscal Year: 2012
    ..The ultimate goal is to help in the development of tailored interventions to address gender-specific manifestations and etiologies. ..
  42. GENETIC STUDY OF AUTISTIC CHILDREN AND ADOLESCENTS
    Edwin Cook; Fiscal Year: 1999
    ..tyrosine hydroxylase, dopamine-beta-hydroxylase, dopamine transporter, aromatiC amino acid decarboxylase, monoamine oxidase (MAO)-A and MAO-B)...
  43. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2002
    ..grant period, the unexpected and remarkable discovery was made that cigarette smokers have lower brain monoamine oxidase (MAO) than non-smokers and former smokers, an effect not caused by nicotine...
  44. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
    ..grant period, the unexpected and remarkable discovery was made that cigarette smokers have lower brain monoamine oxidase (MAO) than non-smokers and former smokers, an effect not caused by nicotine...
  45. THE ROLE OF TYROSINE METABOLISM IN LIVER DISEASE
    BAHJAT FARAJ; Fiscal Year: 1980
    ..by both an increased systemic bioavailability of oral tyramine and decreased metabolism of tyramine by monoamine oxidase enzyme...
  46. PERIPHERAL MARKERS OF STYRENE TOXICITY
    Harvey Checkoway; Fiscal Year: 1990
    ..The specific aims of this research are: 1) to compare levels of dopamine D2 receptors, monoamine oxidase type B and serotonin uptake in circulating platelets, leukocyte concentrations of reduced glutathione, and ..
  47. DOES ATYPICAL DEPRESSION RESPOND TO COGNITIVE THERAPY?
    Robin Jarrett; Fiscal Year: 1993
    ..of this controlled randomized 10 week trial is to compare the differential effectiveness of phenelzine (monoamine oxidase inhibitor (MAOI))...
  48. Antidepressants - same effect on mesolimbic DA activity?
    JAY WEISS; Fiscal Year: 2009
    ..which include chronic administration of two tricyclics, four selective serotonin reuptake inhibitors, one monoamine oxidase inhibitor, three atypical AD drugs, and also electroconvulsive shock...
  49. INACTIVATION, STRUCTURE, AND MECHANISM OF MAO
    Richard Silverman; Fiscal Year: 2002
    ..structure of the modified flavin using NMR and mass spectral techniques after inactivation of a new fungal monoamine oxidase, MAO N; by utilizing the structural information from MAO N to elucidate the modified flavin structures after ..
  50. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..While the likely severity of such bias has been debated in the epidemiologic literature, there have been no studies to assess the extent of this problem in Hispanics, one of the populations that is most likely to be affected. ..
  51. FLAVOENZYME MECHANISMS: REDOX AND NON-REDOX REACTIONS
    MARILYN JORNS; Fiscal Year: 2007
    ..human enzymes, including sarcosine dehydrogenase, an enzyme defective in sarcosinemic patients and monoamine oxidase, a drug target in the treatment of Parkinson's disease and depression...
  52. FUNCTIONS OF GLUTATHIONE PEROXIDASE IN THE BRAIN
    TRENT BUCKMAN; Fiscal Year: 1991
    ..A particular focus of mechanistic studies in this proposal will be the interaction of GPx with monoamine oxidase (MAO), as the principle metabolic enzyme in degradation of the amine neurotransmitters...
  53. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
    ..Dopamine plays a critical role in nicotine reinforcement, and monoamine oxidase B (MAO-B) inhibitors, which preferentially inhibit dopamine metabolism, may have utility for smoking ..
  54. ENVIRONMENTAL/GENETIC RISK FACTORS FOR PARKINSON'S
    Jordan Firestone; Fiscal Year: 2004
    ..abstract_text> ..
  55. Selegiline for Treatment of Cannabis Dependence
    BRENT MOORE; Fiscal Year: 2005
    ..Selegiline, a monoamine oxidase-B inhibitor, increases dopamine activity in mesolimbic and other brain regions involved in dependence on ..
  56. ESTROGEN TREATMENT OF MOOD DISTURBANCES IN THE MENOPAUSE
    EDWARD KLAIBER; Fiscal Year: 1992
    ..One specific aim is to relate ERT's effects on mood and behavior to platelet monoamine oxidase (MAO) activity and EEG "driving" responses, noninvasive and easily accessible indices which theoretically ..
  57. Modeling the Neurogenetics of Serotonin Regulation
    ERIC VALLENDER; Fiscal Year: 2009
    ..This application seeks to explore the neurogenetic diversity of serotonin transporter (SERT) and Monoamine Oxidase A (MAOA) genes in rhesus monkeys...
  58. TREATMENT OF COCAINE-INDUCED 5-HT DYSFUNCTION
    George Battaglia; Fiscal Year: 2005
    ..effects on 5-HT2A receptors can be reversed by increasing the levels of 5-HT in the synapse with selective monoamine oxidase-A (MAO-A) inhibitors...
  59. Neurogenetics of serotonin regulation: building naturalistic rhesus monkey models
    Gregory Miller; Fiscal Year: 2009
    ..focus is on functional polymorphisms in tryptophan hydroxylase 2 (TPH2), serotonin transporter (SERT) and monoamine oxidase A (MAOA) genes in an effort to more accurately model serotonergic neurogenetic variance associated with ..
  60. PHENELZINE, FLUOXENTINE, PLACEBO TRIAL IN OCD
    Michael Jenike; Fiscal Year: 1991
    There are a growing number of case reports which indicate that monoamine oxidase inhibitors may be helpful in patients with obsessive compulsive disorder (OCD)...
  61. BIOGENIC AMINE DISPOSITION IN IRON-DEFICIENT CHILDREN
    JEROME ROTH; Fiscal Year: 1980
    ..disturbances and an overall impairment of intellectual results in a decrease in the activity of platelet monoamine oxidase (MAO), a major enzyme responsible for the inactivation of the biogenic amine neurotransmitters...
  62. Role of Environment in Neuroprotection
    Richard Smeyne; Fiscal Year: 2005
    ..The work proposed and subsequent results generated in the application will be used as pilot data. We believe that the EE model may provide a new approach to prevention of PD symptomatology as well as other neurodegenerative disorders. ..
  63. DEPRENYL/TOCOPHEROL ANTIOXIDATIVE THERAPY OF PARKINSON'S
    Ira Shoulson; Fiscal Year: 1991
    ..Preliminary observations from pilot studies suggest that deprenyl, a relatively selective inhibitor of monoamine oxidase type B, and alpha-tocopherol (vitamin E), an antioxidant with free-radical quenching capacities, may ..
  64. INHIBITION OF MAO A AND MAO B BY TOBACCO ALKALOIDS
    Neal Castagnoli; Fiscal Year: 2000
    ..We submit that these studies should establish or rule out a role for these compounds in the mediation of the loss of MAO-A and MAO-B activity in the brains of smokers. ..
  65. BRAIN CATECHOLAMINES IN CONTROL OF BLOOD PRESSURE
    Curt Freed; Fiscal Year: 1980
    ..group makes the drug and its metabolites methyldopamine (MDA) and methyl-norepinephrine (MNE) resistant to monoamine oxidase (MAO)...
  66. GENE/ENVIRONMENT INTERACTIONS IN PARKINSON'S DISEASE
    Harvey Checkoway; Fiscal Year: 2004
    ..encoding enzymes pertinent to environmental chemical activation and/or detoxification, including: type B monoamine oxidase (MAO-B), cytochromes P450 (CYP) 2D6 and 2EI, and the MI, TI, and PI isozymes of glutathiorie S-transferase (..