estradiol dehydrogenases

Summary

Summary: Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or NADP+ to yield estrone and NADH or NADPH. The 17-hydroxyl group can be in the alpha- or beta-configuration. EC 1.1.1.62

Top Publications

  1. ncbi Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    Agneta Jansson
    Department of Clinical and Experimental Medicine, Division of Oncology, Linkoping University, Linkoping, Sweden
    Clin Cancer Res 15:3610-6. 2009
  2. ncbi 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production
    Juliette A Aka
    Research Center of the Laval University Hospital Center CHUQ CHUL and Laval University, Quebec, Canada
    Mol Endocrinol 24:832-45. 2010
  3. ncbi Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors
    A Jansson
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, S 581 85 Linkoping, Sweden
    Endocr Relat Cancer 13:875-84. 2006
  4. ncbi Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk
    Katie A Ashton
    Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia
    Cancer Epidemiol 34:328-37. 2010
  5. ncbi Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer
    Cecilia Gunnarsson
    Department of Pathology Cytology and Genetics, Division of Genetics, Linkoping University Hospital, Linkoping, Sweden
    Breast Cancer Res Treat 108:35-41. 2008
  6. ncbi SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3095, USA
    Biol Reprod 75:605-14. 2006
  7. pmc The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
    Chen Yan Zhang
    Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier de Université Laval Research Center CHUL, CHUQ and Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e29835. 2012
  8. pmc Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
    Daniel P Sherbet
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocrinology 150:4154-62. 2009
  9. ncbi Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1301-9. 1989
  10. pmc Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1
    Gabriele Moller
    Helmholtz Zentrum Munchen, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany
    PLoS ONE 5:e10969. 2010

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    Agneta Jansson
    Department of Clinical and Experimental Medicine, Division of Oncology, Linkoping University, Linkoping, Sweden
    Clin Cancer Res 15:3610-6. 2009
    ..The aim of this study was to investigate the prognostic and tamoxifen predictive values of 17HSD1 and 17HSD2 expression...
  2. ncbi 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production
    Juliette A Aka
    Research Center of the Laval University Hospital Center CHUQ CHUL and Laval University, Quebec, Canada
    Mol Endocrinol 24:832-45. 2010
    ..These results strongly support the rationale for inhibiting 17beta-HSD1 in breast cancer therapy to eliminate estrogen activation via the sulfatase pathway while avoiding the deprivation of DHT...
  3. ncbi Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors
    A Jansson
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, S 581 85 Linkoping, Sweden
    Endocr Relat Cancer 13:875-84. 2006
    ..Expression of 17HSD type 1 seems to be dominant to 17HSD type 2. Therefore, it may be important to investigate a ratio between 17HSD type 1 and 17HSD type 2...
  4. ncbi Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk
    Katie A Ashton
    Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia
    Cancer Epidemiol 34:328-37. 2010
    ..The environmental and reproductive risk factors that influence these hormones are well known, however, genetic variants involved in hormone biosynthesis and estrogen metabolism have not been well established in endometrial cancer...
  5. ncbi Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer
    Cecilia Gunnarsson
    Department of Pathology Cytology and Genetics, Division of Genetics, Linkoping University Hospital, Linkoping, Sweden
    Breast Cancer Res Treat 108:35-41. 2008
    ..Furthermore, we found that amplification of the gene had prognostic significance in multivariate analysis adjusting for other clinicopathological variables...
  6. ncbi SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3095, USA
    Biol Reprod 75:605-14. 2006
    ....
  7. pmc The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
    Chen Yan Zhang
    Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier de Université Laval Research Center CHUL, CHUQ and Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e29835. 2012
    ..Moreover, kinetic studies were carried out in intact cells as a new approach, using HEK-293 cells over-expressing type 1 and T47D breast cancer cells...
  8. pmc Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
    Daniel P Sherbet
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocrinology 150:4154-62. 2009
    ..These findings suggest that additional structural features, beyond the lack of a specific arginine residue, disfavor NADPH binding and thus support E2 oxidation by 17betaHSD2 in intact cells...
  9. ncbi Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1301-9. 1989
    ....
  10. pmc Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1
    Gabriele Moller
    Helmholtz Zentrum Munchen, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany
    PLoS ONE 5:e10969. 2010
    ..Potentially active human-relevant drugs, therefore, would no longer be further developed. Activity and efficacy screens in heterologous species systems must be evaluated with caution...
  11. ncbi Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors
    Sandrine Marchais-Oberwinkler
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    Mol Cell Endocrinol 301:205-11. 2009
    ..Compound 18 also showed a good selectivity toward 17beta-HSD2 and the estrogen receptors alpha and beta...
  12. ncbi Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions
    Ambros Huber
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Obstet Gynecol 106:1025-31. 2005
    ..We aimed to investigate the association among 10 single nucleotide polymorphisms (SNPs) involved in the estrogen metabolism and endometriosis and to develop a multiple genetic model...
  13. ncbi Bicyclic substituted hydroxyphenylmethanone type inhibitors of 17 β-hydroxysteroid dehydrogenase Type 1 (17 β-HSD1): the role of the bicyclic moiety
    Alexander Oster
    Pharmaceutical and Medicinal Chemistry, Saarland University, and the Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Campus C2 3, P O Box 151150, 66123 Saarbrucken, Germany
    ChemMedChem 6:476-87. 2011
    ..A molecular docking study provided insight into the protein-ligand interactions of this compound with 17β-HSD1...
  14. ncbi New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity
    Emmanuel Bey
    Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    J Med Chem 52:6724-43. 2009
    ..It also shows a high selectivity (17beta-HSD2, ERalpha) and excellent pharmacokinetic properties after peroral application to rats...
  15. ncbi Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase
    Donald Poirier
    Oncology and Molecular Endocrinology Research Center, CHUQ Pavillon CHUL and University Laval, 2705 Laurier Boulevard, Que, Canada G1V 4G2
    Mol Cell Endocrinol 248:236-8. 2006
    ..With an IC50 of 0.8 microM, the 16beta-benzyl-E2 (3a) is the best inhibitor in this series...
  16. ncbi New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
    Josef Messinger
    Solvay Pharmaceuticals Research Laboratories, Hannover, Germany
    Mol Cell Endocrinol 248:192-8. 2006
    ..Furthermore, the pyrimidinone proved its use in vivo by significantly reducing 17betaHSD1-dependent tumor growth in a new nude mouse model...
  17. ncbi Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution
    D Ghosh
    Hauptman Woodward Medical Research Institute, Inc, Buffalo, NY 14203, USA
    Structure 3:503-13. 1995
    ..The amino acid sequence of 17 beta-HSD also differs from that of bacterial 3 alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52 additional residues at the C terminus...
  18. ncbi Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases
    Alexander Oster
    Pharmaceutical and Medicinal Chemistry, Saarland University, and Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Campus C23, D 66123 Saarbrücken, Germany
    J Med Chem 53:8176-86. 2010
    ..The data obtained make these inhibitors interesting candidates for further preclinical evaluation...
  19. ncbi Isolation of vesicles mediating the conversion of 17 beta-estradiol to estrone
    J Adamski
    Max Planck Institute of Experimental Endocrinology, Hannover Federal Republic of Germany
    Eur J Cell Biol 54:166-70. 1991
    ..The estradiol dehydrogenase activity in the isolated particles was enriched 20-fold from the homogenate...
  20. ncbi Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core
    Annamaria Lilienkampf
    Laboratory of Organic Chemistry, Department of Chemistry, P O Box 55, FIN 00014 University of Helsinki, Finland
    J Med Chem 52:6660-71. 2009
    ..1 muM test concentration. Importantly, the majority of these compounds exhibited excellent selectivity over the oxidative isoform 17beta-HSD2 and lacked estrogenic effects in an estrogen receptor (ER) binding assay...
  21. ncbi Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2
    Ming Liang Lu
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUQ and Laval University, Quebec, Quebec G1V 4G2, Canada
    J Biol Chem 277:22123-30. 2002
    ..The kinetic constants using estradiol, testosterone, dihydrotestosterone, and 20 alpha-dihydroprogesterone as substrates were also determined...
  22. ncbi Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
    Josef Messinger
    Solvay Pharmaceuticals Research Laboratories, Hans Böckler Allee 20, D 30173 Hannover, Germany
    Mol Cell Endocrinol 301:216-24. 2009
    ..In conclusion, estrone C15 derivative compound 21 can be regarded as a promising lead compound for further development as a 17beta-HSD1 inhibitor...
  23. ncbi Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25
    Y Tremblay
    Department of Pediatrics, University of California, San Francisco 94143
    J Biol Chem 264:20458-62. 1989
    ..By contrast, cAMP decreases estrogenic 17KSR mRNA in primary cultures of human cytotrophoblasts and human granulosa cells, a pattern of tropic regulation that differs from other steroidogenic enzyme mRNAs...
  24. ncbi Synergistic interaction of growth factors and albumin in regulating estradiol synthesis in breast cancer cells
    A Singh
    Unit of Metabolic Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK
    Mol Cell Endocrinol 85:165-73. 1992
    ..It is concluded that the synergism that results from treating MCF-7 cells with albumin and IGF-I may result from increased albumin uptake and subsequent biological effect...
  25. ncbi Interleukin 6 is secreted by breast fibroblasts and stimulates 17 beta-oestradiol oxidoreductase activity of MCF-7 cells: possible paracrine regulation of breast 17 beta-oestradiol levels
    E F Adams
    Department of Medicine, Royal Liverpool Hospital, UK
    Int J Cancer 49:118-21. 1991
    ..These results indicate that breast stromal fibroblasts may have a paracrine role in regulation of breast-cancer-tissue levels of E2, and that this effect is mediated by IL6 or a closely related peptide...
  26. ncbi Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase
    V Luu-The
    MRC Group in Molecular Endocrinology, Research Centre, Laval University Medical Centre, Quebec, Canada
    Ann N Y Acad Sci 595:40-52. 1990
  27. ncbi 17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines
    Joanna M Day
    Endocrinology and Metabolic Medicine and Sterix Ltd, Imperial College, St Mary s Hospital, London W2 1NY, UK
    Mol Cell Endocrinol 248:246-9. 2006
    ..An understanding of their regulation in both healthy and malignant tissues may lead to future therapeutic intervention at the regulatory level...
  28. ncbi The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer
    A Purohit
    Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College, St Mary s Hospital, London W2 1NY, UK
    Mol Cell Endocrinol 248:199-203. 2006
    ..The identification of potent, selective novel 17beta-HSD1 inhibitors will allow their efficacy to be tested in in vitro and in vivo studies...
  29. ncbi Evaluation of inhibitors for 17beta-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme
    B Husen
    Solvay Pharmaceuticals Research Laboratories, PH REL, Hans Böckler Allee 20, 30173 Hannover, Germany
    Mol Cell Endocrinol 248:109-13. 2006
    ..A dose-response relationship in the inhibitory effect of this compound further confirmed the validity of the model for testing the drug candidates in vivo...
  30. ncbi Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
    Gillian M Allan
    Medicinal Chemistry, Department of Pharmacy and Pharmacology and Sterix Ltd, University of Bath, Claverton Down BA2 7AY, UK
    Mol Cell Endocrinol 248:204-7. 2006
    ..This work has shown that extension from this position on the pyrazole template is well tolerated and the optimization of such systems is under investigation...
  31. ncbi The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors
    R Breton
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, CEA CNRS 41, avenue des Martyrs, F 38027 Grenoble cedex, France
    Structure 4:905-15. 1996
    ..The precise localization and orientation of the substrate and cofactor in the active site is of paramount importance for the design of such inhibitors, and for an understanding of the catalytic mechanism...
  32. pmc The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer
    Atul Purohit
    Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    Breast Cancer Res 4:65-9. 2002
    ..The co-ordinated stimulation of the activities of the enzymes that are involved in estrogen synthesis offers an explanation for the high concentrations of estrogens that are present in breast tumors...
  33. ncbi Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5
    S X Lin
    Molecular Endocrinology Research Center at Laval University Hospital Research Center CHUL, CHUQ, Laval University, Que, Canada G1V 4G2
    Mol Cell Endocrinol 248:38-46. 2006
    ..The multi-specificity contributes significantly to steroid metabolism in peripheral tissues, due to the high levels of 17beta-HSD5 mRNA in both breast and prostate tissues...
  34. pmc Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV
    J Adamski
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Germany
    Biochem J 311:437-43. 1995
    ..0 kb, present in many tissues with highest concentrations in liver, heart, prostate and testes. When over-expressed in mammalian cells, the human 17 beta-HSD IV enzyme displays a specific unidirectional oxidative 17 beta-HSD activity...
  35. ncbi Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer
    Marie Plourde
    Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Quebec and Laval University, Quebec G1V 4G2, Canada
    J Mol Endocrinol 40:161-72. 2008
    ..Ala111Asp appears to affect protein stability resulting in significant decreases in the protein levels, providing valuable information on structure-function relationship...
  36. ncbi Characterization of 17 beta-hydroxysteroid dehydrogenase IV
    J F Carstensen
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Germany
    J Endocrinol 150:S3-12. 1996
    ....
  37. ncbi Regulation of 17beta-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5alpha-dihydrotestosterone in human prostate cancer cells
    Jing Huan Wang
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    J Steroid Biochem Mol Biol 107:100-5. 2007
    ..The regulation of HSD17B2, HSD17B4 and HSD17B5 by ligands of LXR and VDR as well as AR in prostate cancer cells suggests a complex interaction of these signaling systems in the prostate...
  38. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted...
  39. ncbi Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts
    Bettina Husen
    Solvay Pharmaceuticals Research Laboratories, Hans Böckler Allee 20, 30173 Hannover, Germany
    Endocrinology 147:5333-9. 2006
    ..The results evidently show that estrogenic response for E1 is enhanced by the local action of HSD17B1 in vivo, and thus, the enzyme is a potential target for pharmacological inhibition of estrogen action...
  40. ncbi Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region
    G L Murdock
    Biochemistry 25:641-6. 1986
    ....
  41. ncbi How estrogen-specific proteins discriminate estrogens from androgens: a common steroid binding site architecture
    Virginie Nahoum
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec, Quebec G1V 4G2, Canada
    FASEB J 17:1334-6. 2003
    ..As these different estrogen-specific proteins are not related in overall sequence, the inference is that the steroid binding site in these proteins has originated by convergent evolution...
  42. ncbi Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene
    Pia Rantakari
    Department of Physiology, Institute of Biomedicine, University of Turku, FIN 20520 Turku, Finland
    Mol Endocrinol 22:665-75. 2008
    ..Our results provide evidence for a role for HSD17B2 enzyme in the cellular organization of the mouse placenta...
  43. ncbi Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT
    Sari Alho-Richmond
    Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, PO Box 55, FIN 00014, Finland
    Mol Cell Endocrinol 248:208-13. 2006
    ..The boundary surface, hydrophobic interactions and hydrogen bonding sites in the ligand binding domain for each ligand complex were analysed to create a comprehensive image of the active site...
  44. ncbi Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity
    Olga V Belyaeva
    Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 720 20th Street South, 466 Kaul Genetics Building, Birmingham, AL 35294, USA
    Genomics 88:820-30. 2006
    ..Understanding the evolution and divergence of RODH-like enzymes in various vertebrate species should facilitate further investigation of their in vivo functions using animal models...
  45. ncbi Progestins and cancer
    R Sitruk-Ware
    Department of Endocrinology, Hopital Saint Antoine, Paris, France
    Gynecol Endocrinol 13:3-9. 1999
    ..Also, they are useful agents as a second-line therapy for breast cancer, when used at high doses...
  46. ncbi Substrate specificities of peroxisomal members of short-chain alcohol dehydrogenase superfamily: expression and characterization of dehydrogenase part of Candida tropicalis multifunctional enzyme
    Y M Qin
    Biocenter Oulu, University of Oulu, FIN 90570 Oulu, Finland
    J Lipid Res 41:93-8. 2000
    ..As a monofunctional (R)-specific 3-hydroxyacyl-CoA dehydrogenase is currently unavailable, this recombinant enzyme can be used to study the stereochemistry of bile acid synthesis...
  47. ncbi The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases
    S Andersson
    Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Steroid Biochem Mol Biol 53:37-9. 1995
    ..The 17 beta-HSD3 gene is mutated in male pseudohermaphrodites with the genetic disease 17 beta-HSD deficiency...
  48. pmc Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+
    M W Sawicki
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 96:840-5. 1999
    ..One possible outcome of estrogen replacement therapy in vivo could be reduction of E2 levels in breast tissues and hence the reduced risk of estrogen-dependent breast cancer...
  49. ncbi Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection
    Tangui Maurice
    INSERM U 710, Montpellier, F 34095 France University of Montpellier II, Montpellier, F 34095 France c EPHE, Paris, F 75007 France
    Pharmacol Biochem Behav 84:581-97. 2006
    ..Biochemical and physiological arguments for an interaction of neuro(active)steroids with the sigma(1) receptor are analyzed and the impact on physiopathological outcomes in neuroprotection is illustrated...
  50. ncbi Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis
    Satoshi Endo
    Laboratory of Biochemistry, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
    Arch Biochem Biophys 467:76-86. 2007
    ..The replacement of Asp128, Phe129 and Ser137 of AKR1C16 with the corresponding residues (Glu, Ser and Phe, respectively) of AKR1C24 increased the catalytic efficiency for 17beta- and 20alpha-hydroxysteroids...
  51. ncbi Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family
    Y Deyashiki
    Biochemistry Laboratory, Gifu Pharmaceutical University, Japan
    J Biol Chem 270:10461-7. 1995
    ..The liver mRNA content was considerably more abundant than those found in the other tissues, as 17 beta-HSD protein was mainly detected in the liver by Western analysis...
  52. ncbi 17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant
    Yves Tremblay
    Laboratory of Ontogeny and Reproduction, Laval University Medical Center, Centre de Recherche en Biologie de la Reproduction CRBR, Department of Obstetrics and Gynecology, Laval University, Que, Canada G1V 4G2
    Mol Cell Endocrinol 248:118-25. 2006
    ..The production of androgens after the emergence of mature PTII cells should negatively regulate PTII cell maturation and thus, a novel and normal role for androgens in cell reprogramming is proposed...
  53. ncbi The subcellular localization of 17 beta-hydroxysteroid dehydrogenase type 4 and its interaction with actin
    M Markus
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Germany
    J Steroid Biochem Mol Biol 55:617-21. 1995
    ..Interactions of the 17 beta-hydroxysteroid dehydrogenase with cytoskeletal proteins might be mandatory for a topical assignment of enzymatic activity to defined subcellular compartments...
  54. ncbi Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis
    H Ichinose
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 179:183-9. 1991
    ..We further found a striking homology between human SPR and carbonyl reductase, estradiol 17 beta-dehydrogenase, and 3 beta-hydroxy-5-ene steroid dehydrogenase, especially in their N-terminal region...
  55. pmc Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation
    Tobias Klein
    Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany
    PLoS ONE 6:e22990. 2011
    ..Additionally, it facilitates inhibitor design and optimization by offering new information on protein-ligand interactions...
  56. ncbi Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues
    Olayiwola O Oduwole
    Biocenter Oulu, Research Center for Molecular Endocrinology, WHO Collaborating Centre for Research on Reproductive Health, Finland
    Anticancer Res 23:3889-97. 2003
    ..The down-regulation associated with aging may have relevance in the pathogenesis of gastric cancer...
  57. ncbi Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause
    Zhi jian Liu
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
    Cancer Res 65:5802-11. 2005
    ....
  58. ncbi Effect of agricultural antibiotics on the persistence and transformation of 17beta-estradiol in a Sequatchie loam
    Soul Chun
    Biosystems Engineering and Environmental Science Department, University of Tennessee, Knoxville, Tennessee, USA
    J Environ Sci Health B 40:741-51. 2005
    ....
  59. ncbi Progestagenic effects of tibolone are target gene-specific in human endometrial cells
    Wei Zhang
    Department of Obstetrics Gynecology and Reproductive Medicine, SUNY Stony Brook, Stony Brook, New York 11794, USA
    J Soc Gynecol Investig 13:459-65. 2006
    ..The purpose of the current study was to determine the progestagenic actions of Tib and its metabolites using target genes known to be regulated by progestins in human endometrial glandular and stromal cells...
  60. ncbi Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk
    J Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:265-76. 2011
    ..93, P trend=0.003) in the pooled sample. These findings implicate a role of ESR2 in the risk for developing CRC in women and suggest that HSD17B1, ABCB1, and SHBG genes may contribute to sex steroid-mediated effects on CRC development...
  61. ncbi A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta
    G Mendoza-Hernandez
    Biochem Biophys Res Commun 126:477-81. 1985
    ..Homogeneous estradiol 17 beta-dehydrogenase has a specific activity of 7.2 units/mg. and has been purified 2400-fold with a 93% recovery...
  62. ncbi The sequence of porcine 80 kDa 17 beta-estradiol dehydrogenase reveals similarities to the short chain alcohol dehydrogenase family, to actin binding motifs and to sterol carrier protein 2
    F Leenders
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Germany
    Mol Cell Endocrinol 104:127-31. 1994
    ..The N- and C-terminal parts are connected by a sequence containing the putative protease recognition signal AAP...
  63. pmc Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Stalo Karageorgi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 121:54-8. 2011
    ..Endometrial adenocarcinoma is linked to excessive exposure to estrogens. We hypothesized that single nucleotide polymorphisms (SNPs) in genes HSD17b2 and HSD17b4 may alter the enzyme activity, estradiol levels and risk of disease...
  64. ncbi Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model
    Steven Huyghe
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs en Navorsing II, bus 823, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1761:973-94. 2006
    ..In the present review, the identification and biochemical characteristics of MFP-2, and the consequences of MFP-2 dysfunction in humans and in mice will be discussed...
  65. pmc Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis
    L Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Biol Reprod 80:105-14. 2009
    ....
  66. ncbi Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase
    R J Auchus
    Department of Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Steroids 53:77-96. 1989
    ..The propargylic secoestratriene diol also competes with [3H]estradiol for binding to calf uterus estrogen receptor and possesses weak uterotrophic activity...
  67. ncbi The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours
    M J Reed
    Unit of Metabolic Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, U K
    J Steroid Biochem Mol Biol 53:413-20. 1995
    ..Evidence is also reviewed that another steroid sulphatase, dehydroepiandrosterone sulphate sulphatase, may have a crucial role in regulating cytokine production and that this may indirectly control tumour oestrogen synthesis...
  68. ncbi Expression and regulation of aromatase and 17 beta-hydroxysteroid dehydrogenase type 4 in human THP 1 leukemia cells
    F Jakob
    Medizinische Poliklinik, University of Würzburg Röntgenring 11, Germany
    J Steroid Biochem Mol Biol 55:555-63. 1995
    ..These findings may be relevant in the autocrine, paracrine or iuxtacrine cellular crosstalk of myeloid cells in their respective states of terminal differentiation, e.g. in bone metabolism and inflammation...
  69. ncbi Human placental 17 beta-estradiol dehydrogenase: enzymatic activity in the last weeks of pregnancy and electrophoretic data
    R M Corbo
    Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
    Horm Res 35:151-4. 1991
    ..This reduction in enzymatic activity is in good agreement with the data on estrone and estradiol which both show a declining rate of increase in the last weeks of pregnancy...
  70. ncbi Transmitting biological effects of stress in utero: implications for mother and offspring
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK Electronic address
    Psychoneuroendocrinology 38:1843-9. 2013
    ....
  71. ncbi Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis
    Karine Blouin
    Molecular Endocrinology and Oncology Research Ctr, Laval University Medical Research Ctr, 2705 Laurier Blvd T3 67 Québec, QC, Canada G1V 4G2
    Am J Physiol Endocrinol Metab 296:E244-55. 2009
    ..Glucocorticoid-induced androgen inactivation may locally modulate the exposure of adipose cells to active androgens...
  72. ncbi Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats
    I A Adedara
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
    Environ Toxicol Pharmacol 35:444-53. 2013
    ..Kolaviron may prove useful in combating carbendazim-induced reproductive toxicity...
  73. pmc Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2
    F Caira
    Laboratoire de Biologie Moleculaire et Cellulaire, Faculte des Sciences, Universite de Bourgogne, BP400, 21011 Dijon Cedex, France
    Biochem J 330:1361-8. 1998
    ..This paper is the first, to our knowledge, reporting the down-regulation of the expression of genes encoding enzymes involved in the peroxisomal beta-oxidation of fatty acids (MFP-1) and bile acid synthesis (MFP-2) in mammals...
  74. ncbi Activity and gene expression of 17beta-hydroxysteroid dehydrogenase type I in primary cultures of epithelial and stromal cells derived from normal and tumourous human breast tissue: the role of IL-8
    V Speirs
    Department of Medicine, University of Hull, UK
    J Steroid Biochem Mol Biol 67:267-74. 1998
    ..This was reflected in 17-HSD type I activity. Thus, 17-HSD type I is constitutively expressed and active in normal and tumourous breast and can be regulated by IL-8...
  75. ncbi Affinity labeling of cofactor-binding region of human placental estradiol 17 beta-dehydrogenase by periodate-oxidized NADP+ (o-NADP+)
    H Inano
    National Institute of Radiological Sciences, Chiba shi, Japan
    Biochem Biophys Res Commun 158:617-23. 1989
    ..These results indicate that the residue(s) of lysines is located near the cofactor-binding region of estradiol 17 beta-dehydrogenase of human placenta...
  76. ncbi Effects of human breast fibroblasts on growth and 17 beta-estradiol dehydrogenase activity of MCF-7 cells in culture
    E F Adams
    Department of Chemical Pathology, St Mary s Hospital Medical School, London, United Kingdom
    Breast Cancer Res Treat 11:165-72. 1988
    ..These results demonstrate that human breast fibroblasts may have paracrine influences on neighboring epithelial cells in vivo...
  77. ncbi 17-beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology
    H Sasano
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Oncology 59:5-12. 2000
    ..02). These results indicate that oxidation of E(2) to E(1) is dominant in endometrial carcinoma, 17 beta-HSD types 1 and 2 play an important role in the regulation of in situ estrogen production in breast and endometrial carcinoma...
  78. pmc Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention
    H S Feigelson
    American Cancer Society, National Home Office, Atlanta, Georgia 30329 4251, USA
    Breast Cancer Res 2:277-82. 2000
    ..One such tool is the development of a multigenic model of breast cancer susceptibility that can be used to screen women in order to identify those who carry a combination of alleles that puts them at significantly increased risk...
  79. ncbi Expression of 17beta-hydroxysteroid dehydrogenase type 2 in pelvic endometriosis
    Marcia M Carneiro
    Department of Obstetrics and Gynecology, University of Minas Gerais, Belo Horizonte, Brazil
    Gynecol Endocrinol 23:188-92. 2007
    ....
  80. ncbi C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation
    Christine Cadot
    Oncology and Molecular Endocrinology Research Center, CHUQ Pavillon CHUL and Université Laval, Quebec, Canada
    Bioorg Med Chem 15:714-26. 2007
    ..Interestingly, the new inhibitors were also found less estrogenic than the lead compound in two breast cancer cell lines, T-47D and MCF-7...
  81. ncbi Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells
    Leena Strauss
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Endocrinology 150:2865-72. 2009
    ....
  82. ncbi Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant
    Ofure Obazee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376, Stuttgart, Germany
    Breast Cancer Res Treat 138:543-8. 2013
    ....
  83. ncbi Estrogen synthesis, estrogen metabolism, and functional estrogen receptors in rat arterial smooth muscle cells in culture
    F Bayard
    INSERM U397, Institut Louis Bugnard, CHU Rangueil, Toulouse, France
    Endocrinology 136:1523-9. 1995
    ..This in vitro model is convenient for studying the mechanisms of action of estrogen hormones that seem very peculiar in this cell population...
  84. ncbi Human type 2 17beta-hydroxysteroid dehydrogenase in umbilical vein and artery endothelial cells: differential inactivation of sex steroids according to the vessel type
    Marc Simard
    Reproduction, Perinatal Health, and Child Health Axis, CHUQ Research Center, 2705 Laurier Blvd, Rm T 1 49, Quebec, QC G1V 4G2, Canada
    Endocrine 40:203-11. 2011
    ..Our data support a differential modulation of biologically active sex steroid levels according to the vessel type in the foeto-placental unit, with apparent higher inactivation in the arterial system...
  85. ncbi Ethanolic extracts of black cohosh (Actaea racemosa) inhibit growth and oestradiol synthesis from oestrone sulphate in breast cancer cells
    Suman Rice
    Developmental and Endocrine Signalling, Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Maturitas 56:359-67. 2007
    ....
  86. ncbi Corticotropin-releasing hormone stimulates estrogen biosynthesis in cultured human placental trophoblasts
    Xingji You
    Department of Physiology, Second Military Medical University, Shanghai 200433, People s Republic of China
    Biol Reprod 74:1067-72. 2006
    ..These results suggest that, in the placenta, endogenously produced CRH exhibits a tonic stimulatory effect on estrogen production...
  87. ncbi The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells
    Pasi Huuskonen
    University of Eastern Finland, Faculty of Health Sciences, School of Pharmacy, FI 70211 Kuopio, Finland
    Toxicol Lett 218:200-6. 2013
    ..These alterations may lead to anomalies in the foetoplacental hormonal homeostasis...
  88. ncbi Overexpression of 17β-hydroxysteroid dehydrogenase type 1 increases the exposure of endometrial cancer to 17β-estradiol
    Karlijn M C Cornel
    Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:E591-601. 2012
    ..The local interconversions between estrone (low activity) and 17β-estradiol (potent compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high 17β-estradiol generation in endometrial cancer (EC)...
  89. ncbi Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation
    Pierre R Provost
    Laboratory of Ontogeny, Centre Hospitalier Universitaire de Quebec, Pavillon Centre Hospitalier de l Université Laval, Quebec, Canada G1V 4G2
    J Clin Endocrinol Metab 87:3883-92. 2002
    ..This is in line with reported cases of familial incidence of respiratory distress...
  90. pmc Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon
    Agnieszka Anna Rawłuszko
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
    BMC Cancer 11:522. 2011
    ....
  91. ncbi 17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold
    William M Brown
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Chem Biol Interact 143:481-91. 2003
    ....
  92. pmc Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion
    Frauke Beilstein
    Universite Pierre et Marie Curie, UMR S 872, Les Cordeliers, Paris, France
    PLoS ONE 8:e53017. 2013
    ....
  93. ncbi Regulation of estradiol 17 beta-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells
    M J Reed
    Unit of Metabolic Medicine, St Mary s Hospital Medical School, Imperial College of Science, Technology, and Medicine, London, United Kingdom
    Endocrinology 135:4-9. 1994
    ..3-kb mRNA induced by RA is associated with an increase in 17 beta HSD reductive activity, but that endogenous cofactor levels may determine the direction in which this enzyme acts in T47D cells...
  94. ncbi Relationships between the transcriptome and physiological indicators of reproduction in female rainbow trout over an annual cycle
    Sharon E Hook
    Battelle PNNL MSL, Sequim, Washington, USA
    Environ Toxicol Chem 30:309-18. 2011
    ..These results suggest that transcriptional networks along the BPGL axis may be regulated by factors other than circulating steroid hormones...
  95. pmc Polymorphisms in genes involved in the estrogen pathway and mammographic density
    Isabelle Dumas
    Universite Laval, Departement de Medecine sociale et preventive, Quebec City, QC, Canada
    BMC Cancer 10:636. 2010
    ..Effect modification of four estrogen-related factors (parity, age at menarche, hormonal derivatives use and body mass index (BMI)) on this relation is also assessed...
  96. ncbi Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization
    Zhuo Li
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Centre CRCHUL and Laval University, Quebec City, Quebec, Canada
    Histol Histopathol 24:273-82. 2009
    ..The present results indicate the enzymes which play a role in the synthesis and metabolism of E2 are expressed in both epithelial and stromal cells in human breast...
  97. pmc Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer
    Minja J Pfeiffer
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Med 17:657-64. 2011
    ..Therapies targeting the metabolism of adrenal steroids by the tumor may prove effective in preventing tumor regrowth...
  98. ncbi Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters
    B Han
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center, 2705 Laurier Blvd, Quebec City, QC, G1V 4G2, Canada
    J Steroid Biochem Mol Biol 112:194-200. 2008
    ..The decrease in 17beta-HSD type 2 and 17beta-HSD type 5 expressions in breast cancer may play a predominant role in the development and/or progression of the cancer by modifying the intratumoral levels of estrogens and androgens...
  99. ncbi Local biosynthesis of estrogen in human endometrial carcinoma through tumor-stromal cell interactions
    Naomi Takahashi-Shiga
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Clin Cancer Res 15:6028-34. 2009
    ..However, the effect of tumor-stromal interactions on local estrogen biosynthesis in endometrial carcinomas remains largely unknown...
  100. ncbi The histochemistry of oestradiol-17 beta and isocitric dehydrogenases in endometrial carcinoma
    G Lane
    Academic Department of Obstetrics and Gynaecology, Kings College Hospital, Denmark Hill, London, U K
    J Steroid Biochem 33:853-8. 1989
    ..It may therefore be useful as a simple test of the prediction of the sensitivity of endometrial carcinoma to progestogens...
  101. ncbi Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17
    F Labrie
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    J Steroid Biochem 34:189-97. 1989
    ..Using hp E2DH-36 cDNA as a probe for in situ hybridization of translocated chromosomes, the human E2DH gene was localized to the q11-q12 region of chromosome 17...

Research Grants8

  1. Genetic Susceptibility to Infection Related Cancer
    Ikuko Kato; Fiscal Year: 2005
    ..Secondary aims include to examine histopathological correlates of these polymorphisms and to determine whether selected environmental factors modify the above associations. ..
  2. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  3. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  4. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  5. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2008
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  6. Hormones, hormone-related genes, and colorectal cancer
    Jennifer Lin; Fiscal Year: 2008
    ..Findings from the proposed study of estrogen and progesterone will enhance our understanding of these lifestyle and genetic factors in relation to colorectal carcinogenesis. ..
  7. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..