11 beta hydroxysteroid dehydrogenase type 2

Summary

Summary: An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

Top Publications

  1. ncbi Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates
    Atanas G Atanasov
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne CH 3010, Switzerland
    Biochem Biophys Res Commun 308:257-62. 2003
  2. ncbi Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
    James S Gilmour
    Endocrinology Unit, Centre for Cardiovascular Sciences, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, University of Edinburgh, UK
    J Immunol 176:7605-11. 2006
  3. ncbi Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation
    E Schoof
    Department of Pediatrics, University of Erlangen-Nuremberg, Germany
    Eur J Endocrinol 145:187-92. 2001
  4. ncbi Alterations in human placental 11beta-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour
    V E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New South Wales 2310, Australia
    Placenta 24:739-44. 2003
  5. ncbi Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery
    J Dy
    Department of Obstetrics, University of Western Ontario, London, Ontario N6C 6B5, Canada
    Placenta 29:193-200. 2008
  6. ncbi Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
  7. ncbi Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis
    R Claus
    Universitat Hohenheim, Institut für Tierhaltung und Tierzüchtung, Fachgebiet Tierhaltung und Leistungsphysiologie 470 A, Stuttgart, Germany
    Exp Clin Endocrinol Diabetes 113:262-7. 2005
  8. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
  9. ncbi 11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate
    Ren Shan Ge
    The Population Council, 1230 York Avenue, New York, New York 10021, USA
    Endocrinology 146:2657-64. 2005
  10. ncbi Aromatase and 11beta-hydroxysteroid dehydrogenase 2 localisation in the testes of pigs from birth to puberty linked to changes of hormone pattern and testicular morphology
    A Wagner
    Universitat Hohenheim, Institut für Tierhaltung und Tierzüchtung, Fachgebiet Tierhaltung und Leistungsphysiologie 470A, Garbenstr 17, 70599 Stuttgart, Germany
    Reprod Fertil Dev 20:505-12. 2008

Research Grants

  1. ANDROGEN METABOLISM IN CHILDHOOD
    Maria New; Fiscal Year: 2006
  2. ENDOTHELIAL DERIVED STEROID SIGNALS AND TISSUE STRUCTURE
    SIMON SLIGHT; Fiscal Year: 2002
  3. IUGR Affects Renal 11?-HSD2 Epigenetic Characteristics
    Mariana Baserga; Fiscal Year: 2009
  4. Adrenal decommissioning and hypertension
    Elise Gomez Sanchez; Fiscal Year: 2007
  5. ALDOSTERONE, HYPERTENSION AND THE BRAIN
    Elise Gomez Sanchez; Fiscal Year: 2003
  6. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
  7. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
  8. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
  9. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
  10. Maternal Programming of Gene Expression Through DNA Methylation
    MICHAEL JOSEPH MEANEY; Fiscal Year: 2010

Detail Information

Publications221 found, 100 shown here

  1. ncbi Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates
    Atanas G Atanasov
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne CH 3010, Switzerland
    Biochem Biophys Res Commun 308:257-62. 2003
    ....
  2. ncbi Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
    James S Gilmour
    Endocrinology Unit, Centre for Cardiovascular Sciences, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, University of Edinburgh, UK
    J Immunol 176:7605-11. 2006
    ..These data point to an early role for 11beta-HSD1 in promoting the rapid clearance of apoptotic cells during the resolution of inflammation and indicate a novel target for therapy...
  3. ncbi Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation
    E Schoof
    Department of Pediatrics, University of Erlangen-Nuremberg, Germany
    Eur J Endocrinol 145:187-92. 2001
    ..11beta-HSD2 up-regulation may also lead to an increase in PGDH mRNA concentrations that, until term, possibly delays myometrial contractions induced by prostaglandins...
  4. ncbi Alterations in human placental 11beta-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour
    V E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New South Wales 2310, Australia
    Placenta 24:739-44. 2003
    ..This decrease in type 2 activity, along with an increase in 11beta-HSD1 gene expression may be a mechanism by which cortisol concentrations rise at term to regulate fetal maturation and activate pathways associated with labour...
  5. ncbi Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery
    J Dy
    Department of Obstetrics, University of Western Ontario, London, Ontario N6C 6B5, Canada
    Placenta 29:193-200. 2008
    ..Taken together, our present findings provide evidence suggesting a role for an attenuated placental as well as fetal 11beta-HSD2 in the pathogenesis of IUGR...
  6. ncbi Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
    ..To identify disease-specific gene expression profiles in patients with rheumatoid arthritis (RA), using complementary DNA (cDNA) microarray analyses on lymphoblastoid B cell lines (LCLs) derived from RA-discordant monozygotic (MZ) twins...
  7. ncbi Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis
    R Claus
    Universitat Hohenheim, Institut für Tierhaltung und Tierzüchtung, Fachgebiet Tierhaltung und Leistungsphysiologie 470 A, Stuttgart, Germany
    Exp Clin Endocrinol Diabetes 113:262-7. 2005
    ..47 +/- 0.14 pmol x min (-1) x mg (-1) compared to immunized boars. It is concluded that the 11beta-HSD system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis...
  8. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  9. ncbi 11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate
    Ren Shan Ge
    The Population Council, 1230 York Avenue, New York, New York 10021, USA
    Endocrinology 146:2657-64. 2005
    ..These data suggest that both types I and II 11beta HSD in Leydig cells play a protective role, opposing the adverse effects of excessive CORT on testosterone production...
  10. ncbi Aromatase and 11beta-hydroxysteroid dehydrogenase 2 localisation in the testes of pigs from birth to puberty linked to changes of hormone pattern and testicular morphology
    A Wagner
    Universitat Hohenheim, Institut für Tierhaltung und Tierzüchtung, Fachgebiet Tierhaltung und Leistungsphysiologie 470A, Garbenstr 17, 70599 Stuttgart, Germany
    Reprod Fertil Dev 20:505-12. 2008
    ..Expression was low from 3 to 5 weeks, was resumed after Week 5 and was maximal at Week 17. The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3...
  11. ncbi Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Hypertension 42:123-9. 2003
    ..These genetic and biochemical data emphasize the heterogeneous nature of AME and the effects that heterozygosity at the HSD11B2 locus can have on blood pressure in later life...
  12. ncbi Glutamate-115 renders specificity of human 11beta-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+
    Peter Arnold
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Freiburgstrasse 15, Switzerland
    Mol Cell Endocrinol 201:177-87. 2003
    ..Thus, predictions using the 3D-model combined with analysis of mutants allowed the identification of residues critical for NAD(+)-dependent activity of 11beta-HSD2...
  13. ncbi Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster analysis
    Ren Shan Ge
    The Population Council, New York, New York 10021, USA
    Biol Reprod 72:1405-15. 2005
    ..Thus, gene profiling demonstrates that postnatal development is associated with changes in the expression levels of several different clusters of genes consistent with the processes of Leydig cell growth and differentiation...
  14. ncbi Chronic umbilical cord compression results in accelerated maturation of lung and brown adipose tissue in the sheep fetus during late gestation
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    Am J Physiol Endocrinol Metab 289:E456-65. 2005
    ..In conclusion, chronic UCC results in precocious maturation of the fetal lung and BAT mitochondria, an adaptation largely mediated by the surge in fetal plasma cortisol and catecholamines that accompanies UCC...
  15. ncbi Acute intrarenal administration of cortisol has no effect on renal blood flow in hypertensive individuals
    Stan H M van Uum
    Division of General Internal Medicine, Division of Endocrinology, Department of Medicine, University Medical Center, Nijmegen, The Netherlands
    J Hypertens 20:2275-83. 2002
    ..Cortisol is known to increase blood pressure. One possible mechanism is the reported increase in renal vascular resistance (RVR). It is unknown whether this is due to a direct effect of cortisol on the kidneys...
  16. ncbi Glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity
    Brigitte Bocchi
    INSERM U478, IFR02, Universite Paris 7, Faculte de Medecine X Bichat, BP 416, France
    J Steroid Biochem Mol Biol 84:239-44. 2003
    ..Such partial agonist activity of 11-DHC is discussed in the light of its positioning in a three-dimensional model of the MR ligand-binding domain...
  17. ncbi Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity
    Jeremy W Tomlinson
    Division of Medical Sciences, Queen Elizabeth Hospital, University of Birmingham, Birmingham, United Kingdom B15 2TH
    J Clin Endocrinol Metab 88:2113-8. 2003
    ..09, GH vs. placebo, P = 0.07). Treatment with low-dose GH in obesity fails to alter fat mass despite a significant elevation in IGF-I and a shift in the global set point of E to F conversion consistent with inhibition of 11 beta-HSD1...
  18. ncbi Effect of immunosuppressive and other drugs on the cortisol-cortisone shuttle in human kidney and liver
    M Quinkler
    Clinical Endocrinology, Department of Internal Medicine, Center for Gastroenterology, Heptology and Endocrinology, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:555-9. 2007
    ..We tested immunosuppressive drugs that cause hypertension, and substances that interfere with steroidogenesis or influence glucose homeostasis for their ability to influence the inhibition of 11beta-HSD isozymes...
  19. ncbi [11 beta-hydroxysteroid dehydrogenase type 2 activity in Chilean patients with hypertension]
    Lorena Mosso
    Departamentos de Endocrinología y Medicina Interna, Centro de Investigaciones Medicas, Escuela de Medicina, Pontificia Universidad Catolica de Chile
    Rev Med Chil 130:1201-8. 2002
    ..If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure...
  20. ncbi Developmental programming of renal glucocorticoid sensitivity and the renin-angiotensin system
    Caitlin S Wyrwoll
    School of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Australia
    Hypertension 50:579-84. 2007
    ..Partial prevention of programmed changes in renal gene expression by postnatal dietary omega-3 fatty acids provides insight into how this intervention prevents hypertension induced by fetal glucocorticoid excess...
  21. ncbi Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
    Elise P Gomez-Sanchez
    Endocrine Section and Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA
    Am J Physiol Endocrinol Metab 285:E272-9. 2003
    ..NAD+-dependent enzymatic activity in the absence or presence of a reducing agent demonstrated that the increase in 11betaHSD2 protein was not associated with an increase in in vitro activity unless the dimers were reduced to monomers...
  22. pmc Local and systemic glucocorticoid metabolism in inflammatory arthritis
    R Hardy
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Ann Rheum Dis 67:1204-10. 2008
    ..Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone)...
  23. ncbi Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1
    Christian D Heiniger
    Division of Nephrology and Hypertension, University of Berne, 3010 Berne, Switzerland
    FASEB J 17:917-9. 2003
    ..Thus, hypoxia decreases 11beta-HSD2 transcription and activity by inducing Egr-1 in vivo and in vitro. This mechanism might account for enhanced renal sodium retention and hypertension associated with hypoxic conditions...
  24. ncbi Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:1178-85. 2008
    ..Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue...
  25. ncbi Human adrenal cortex and aldosterone secreting adenomas express both 11beta-hydroxysteroid dehydrogenase type 1 and type 2 genes
    Giovanna Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 9:495-8. 2002
    ....
  26. ncbi Glucocorticoid availability in colonic inflammation of rat
    P Ergang
    Institute of Physiology, Czech Academy of Sciences, Prague, The Czech Republic
    Dig Dis Sci 53:2160-7. 2008
    ..However, these changes in the local metabolism of glucocorticoids do not modulate the expression of COX-2, TNF-alpha, and IL-1beta in inflamed tissue...
  27. ncbi Cortisol is a suppressor of apoptosis in bovine corpus luteum
    Junichi Komiyama
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    Biol Reprod 78:888-95. 2008
    ....
  28. ncbi Increased cortisol metabolites and reduced activity of 11beta-hydroxysteroid dehydrogenase in patients on hemodialysis
    Verena N'Gankam
    Division of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Kidney Int 61:1859-66. 2002
    ..We hypothesized that first, these metabolites accumulate and second, their concentration pattern changes in patients on hemodialysis...
  29. ncbi 11beta-hydroxysteroid dehydrogenase type 1 and obesity
    Nicholas M Morton
    Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute, Edinburgh University, Edinburgh, UK
    Front Horm Res 36:146-64. 2008
    ....
  30. ncbi 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids
    Sven Diederich
    Department of Endocrinology, Diabetes, and Nutrition, Klinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    J Clin Endocrinol Metab 87:5695-701. 2002
    ..To characterize a GC or a MC as substrate for the different 11betaHSDs may be essential for an optimized steroid therapy...
  31. ncbi Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension
    S Rauz
    Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
    QJM 96:481-90. 2003
    ....
  32. ncbi Glucocorticoid exposure and tissue gene expression of 11beta HSD-1, 11beta HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth
    Christopher J McNeil
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Reproduction 133:653-61. 2007
    ..This study examines GC exposure in naturally occurring differential growth and simultaneously explores tissue GC sensitivity and handling, at three key stages of gestation...
  33. ncbi 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Curr Opin Pharmacol 4:597-602. 2004
    ..Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders...
  34. ncbi [11beta-hydroxysteroide dehydrogenases. Recent advances]
    M C Vantyghem
    Service d Endocrinologie et Métabolisme, clinique d endocrinologie Marc Linquette, 6, rue du Professeur Laguesse, CHRU de Lille, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 68:349-56. 2007
    ..The understanding of action mechanisms of these two enzymes currently leads to 11beta-OHSD inhibitors development, therefore opening new therapeutic strategies, especially in metabolic syndrome...
  35. ncbi Use of 11alpha-deuterium labeled cortisol as a tracer for assessing reduced 11beta-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject
    Yasuji Kasuya
    Department of Medicinal Chemistry and Clinical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Steroids 70:117-25. 2005
    ..The 2H-labeling in the 11alpha-position of cortisol served as an appropriate tracer for assessing the reduced 11beta-HSD2 activity in vivo induced by glycyrrhetinic acid...
  36. ncbi Cortisol resistance in conditions such as asthma and the involvement of 11beta-HSD-2: a hypothesis
    E Pretorius
    Department of Anatomy, School of Health Sciences, Medical Faculty of the University of Pretoria, South Africa
    Horm Metab Res 38:368-76. 2006
    ..These are some of the symptoms typically noted in cortisol resistance...
  37. ncbi [Tissue-specific changes in cortisol metabolism and their potential role in the metabolic syndrome]
    M N Kerstens
    Universitair Medisch Centrum Groningen, Afd Endocrinologie, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 149:871-6. 2005
    ..Pharmacological inhibition of IIbettaHSD type I activity provides an interesting mechanism for the development of novel therapeutic agents for type-2 diabetes mellitus...
  38. ncbi 11Beta-hydroxysteroid dehydrogenases in human endometrium
    Sarah E McDonald
    Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh School of Clinical Sciences and Community Health, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Cell Endocrinol 248:72-8. 2006
    ..The MR expression pattern across the cycle and in decidua implies progesterone may also play a regulatory role. The precise roles and interactions of these proteins require further investigation...
  39. ncbi Ontogeny and nutritional programming of adiposity in sheep: potential role of glucocorticoid action and uncoupling protein-2
    Muhuntha G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Chemical Research, University of Nottingham, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 289:R1407-15. 2005
    ..We conclude that the continual rise in glucocorticoid action and fat mass after birth may underlie the development of later obesity. The magnitude of this adaptation is partly dependent on maternal food intake through pregnancy...
  40. ncbi Pharmacodynamics and pharmacokinetics of synthetic mineralocorticoids and glucocorticoids: receptor transactivation and prereceptor metabolism by 11beta-hydroxysteroid-dehydrogenases
    S Diederich
    Dept of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Horm Metab Res 36:423-9. 2004
    ..For GC therapy directed to HSD2-expressing organs, widely used prednisolone does not seem to be the optimal recommendation...
  41. ncbi The role of glucocorticoid in the regulation of prostaglandin biosynthesis in non-pregnant bovine endometrium
    Hwa Yong Lee
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    J Endocrinol 193:127-35. 2007
    ....
  42. ncbi Expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in colorectal cancer
    Sárka Zbánková
    Department of Internal Medicine, Charles University, Prague, Czech Republic
    Cancer Lett 210:95-100. 2004
    ....
  43. ncbi 11Beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology
    Victoria Sharp
    Endocrine Signalling Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    Reproduction 134:473-82. 2007
    ....
  44. ncbi 11beta-hydroxysteroid dehydrogenase and glucocorticoid receptor messenger RNA expression in porcine placentae: effects of stage of gestation, breed, and uterine environment
    H G Klemcke
    USDA ARS, Roman L Hruska U S Meat Animal Research Center, Clay Center, Nebraska 68933, USA
    Biol Reprod 69:1945-50. 2003
    ..Moreover, a role for glucocorticoids in porcine embryonic development is suggested...
  45. ncbi 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action
    Nicole Draper
    Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Endocrinol 186:251-71. 2005
    ..In each case, these clinical studies have been underpinned by studies in vitro and the manipulation of enzyme expression in vivo using recombinant mouse models...
  46. ncbi 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids
    Clare Christy
    School of Molecular and Clinical Medicine, Endocrinology Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Hypertension 42:580-7. 2003
    ..Therefore, additional mechanisms, possibly involving indirect effects of enhanced corticosterone action in the kidney and the resultant hypertension, must be involved...
  47. ncbi Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action
    Paul M Stewart
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Eur J Endocrinol 149:163-8. 2003
    ..Modulation of enzyme activity may offer a future therapeutic approach to treating these diseases whilst circumventing the endocrine consequences of glucocorticoid excess or deficiency...
  48. ncbi Low endogenous glucocorticoid allows induction of kidney cortical cyclooxygenase-2 during postnatal rat development
    Kirsten Madsen
    Department of Physiology and Pharmacology, University of Southern Denmark, Winsløwparken 21, 3, DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 286:F26-37. 2004
    ..Increased circulating glucocorticoid in the postnatal period may damage late renal development through inhibition of COX-2...
  49. ncbi Plasma cortisol and cortisone concentrations in normal subjects and patients with adrenocortical disorders
    Hiroyuki Morita
    Department of General Medicine, Gifu University School of Medicine, Tsukasamachi, Japan
    Metabolism 53:89-94. 2004
    ..Alternation of 11-HSD2 activities as well as corticosteroid levels may be important in the pathophysiology of adrenocortical disorders...
  50. ncbi Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
    Christina Jang
    Department of Endocrinology and Diabetes, St Vincent s Hospital, Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    J Clin Endocrinol Metab 92:3314-20. 2007
    ..There is little information regarding the regulation of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes in skeletal muscle in the setting of type 2 diabetes...
  51. ncbi Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated
    Ren Shan Ge
    Population Council, New York, NY 10021, USA
    Mol Cell Endocrinol 243:35-42. 2005
    ..We conclude that Leydig cells express MRs and that testosterone production is subject to regulation by aldosterone...
  52. ncbi Tissue-specific programming expression of glucocorticoid receptors and 11 beta-HSDs by maternal perinatal undernutrition in the HPA axis of adult male rats
    I Dutriez-Casteloot
    Neurosciences et Neurophysiologie Adaptatives, Equipe Stress Périnatal, Universite de Lille I, Villeneuve d Ascq, France
    Horm Metab Res 40:257-61. 2008
    ....
  53. ncbi Expression of the 11beta-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells
    K Koyama
    Laboratories of Molecular Hypertension, Baker Medical Research Institute, P.O. Box 6492, St. Kilda Rd Central, 8008, Melbourne, Australia
    J Steroid Biochem Mol Biol 76:153-9. 2001
    ..This study shows that 11betaHSD2 activity and cell proliferation of PMC42 cells can be modulated via steroid receptors...
  54. ncbi Increased ACTH levels do not alter renal 11beta-hydroxysteroid dehydrogenase type 2 gene expression in the sheep
    A L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Endocr J 48:119-22. 2001
    ....
  55. ncbi Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung
    C Finckh
    Department of Pharmacology and Toxicology, School of Medicine, Karl von Frisch Strasse 1, Philipps University of Marburg, D 35033, Marburg, Germany
    Chem Biol Interact 130:761-73. 2001
    ....
  56. ncbi Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta
    A Atalla
    Department of Pharmacology and Toxicology, School of Medicine, Philipps-University of Marburg, D-35033, Marburg, Germany
    Chem Biol Interact 130:737-48. 2001
    ..1.1.184) seems to perform this reaction in human placenta cytosol. The presence of carbonyl reductase was confirmed by RT-PCR. This is the first report to provide evidence that NNAL formation in placenta is mediated by carbonyl reductase...
  57. ncbi Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies
    P M Driver
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Mol Hum Reprod 7:357-63. 2001
    ..The presence of the MR within trophoblast indicates that some of the effects of cortisol could be MR- rather than GR-mediated...
  58. ncbi Apparent mineralocorticoid excess
    R C Wilson
    Pediatric Endocrinology, New York-Presbyterian Hospital and the Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Trends Endocrinol Metab 12:104-11. 2001
    ..In 1998, a mild form of this disease was reported, which might represent an important cause of low-renin hypertension. Early and vigilant treatment might prevent or improve the morbidity and mortality of end-organ damage...
  59. ncbi Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes
    B M Abdallah
    KMEB, Department of Endocrinology, Odense University Hospital, Denmark
    Eur J Clin Invest 35:627-34. 2005
    ....
  60. ncbi Stimulation of 11-beta-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake
    Rikke Nørregaard
    Department of Physiology and Pharmacology, University of Southern Denmark, Winsloewparken 21, 3 DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 285:F348-58. 2003
    ..These data indicate that mineralocorticoid selectivity is physiologically regulated by NaCl intake at the level of 11betaHSD-2 expression and tissue distribution in the distal colon, but not in the kidney...
  61. ncbi Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....
  62. ncbi Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye
    S Rauz
    Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 42:2037-42. 2001
    ..11 mm Hg, P < 0.0001 and 11.78 +/- 1.50 mm Hg, P < 0.0001, respectively). CONCLUSIONS: These results suggest that the 11 beta-HSD1 isozyme may modulate steroid-regulated sodium transport across the NPE, thereby influencing IOP...
  63. ncbi Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man
    M Palermo
    Children s Hospital Oakland Research Institute, CA 94609, USA
    Clin Endocrinol (Oxf) 45:605-11. 1996
    ..We have validated the measurement of urinary free cortisone (UFE) excretion in normals and in patients with disorders of the pitultary-adrenal axis in an attempt to more accurately measure the activity of 11 beta-HSD2 in vivo...
  64. ncbi The role of the 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension
    P Ferrari
    Division of Nephrology and Hypertension, University of Berne, Switzerland
    J Hypertens 18:241-8. 2000
    ..These findings suggest that variants of the HSD11 B2 gene may contribute to the enhanced blood pressure response to salt in some humans...
  65. ncbi Local modulation by 11beta-hydroxysteroid dehydrogenase of glucocorticoid effects on the activity of 15-hydroxyprostaglandin dehydrogenase in human chorion and placental trophoblast cells
    F A Patel
    University of Toronto, Department of Physiology, Ontario, Canada
    J Clin Endocrinol Metab 84:395-400. 1999
    ..However, F and DEX inhibited PGDH, and the effect of F (but not DEX) was greater in the presence of CBX. In conclusion, we suggest that effects of E and F on PGDH are modified by the tissue-specific expression of 11beta-HSD isoforms...
  66. ncbi The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes
    Z Krozowski
    Baker Medical Research Institute, Alfred Hospital, Melbourne, Australia
    J Steroid Biochem Mol Biol 69:391-401. 1999
    ....
  67. ncbi Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation
    Junny Chan
    Division of Reproduction and Child Health, Department of Fetal Medicine, Birmingham Women s Hospital, University of Birmingham, Birmingham B15 2TH, UK
    J Endocrinol 195:7-15. 2007
    ..These data show that autocrine metabolism of glucocorticoids is an important facet of the feto-placental unit in late gestation and we propose that a possible effect of this is to stimulate programmed cell death in human decidua...
  68. ncbi Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:493-500. 2003
    ..Whether these conditions are associated with early postnatal adrenal insufficiency or long-term cardiovascular risk remains an important issue for further study...
  69. ncbi Does kidney transplantation normalise cortisol metabolism in apparent mineralocorticoid excess syndrome?
    M Palermo
    Institute of Endocrinology, University of Sassari, Italy
    J Endocrinol Invest 23:457-62. 2000
    ..Moreover, it suggests a new therapeutic strategy in particularly vulnerable cohorts of patients inadequately responsive to drug therapy or with kidney failure...
  70. ncbi Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus
    A J Sinclair
    Department of Neuroscience, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK
    J Neuroendocrinol 19:614-20. 2007
    ..Expression of 11beta-HSD1 may be fundamental in the regulation of CSF secretion and the local generation of cortisol may represent a pathophysiological mechanism underlying cortisol-dependent neuroendocrine diseases...
  71. ncbi Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks
    B Watson
    Division of Nephrology, University of Alabama School of Medicine, Birmingham
    Hypertension 28:478-82. 1996
    ..Confirmation of our findings in another independently ascertained group of hypertensive subjects will provide a basis for proceeding with sib-pair linkage analyses...
  72. pmc Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat
    Elise P Gomez-Sanchez
    Research Service, GV Sonny Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA
    Endocrinology 149:525-33. 2008
    ..This antibody against the H6PDH should prove useful for further studies of enzyme activity requiring NADPH generation within the endoplasmic reticulum...
  73. ncbi Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line
    Hans Peter Gaeggeler
    Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    J Am Soc Nephrol 16:878-91. 2005
    ..Within the physiologic range of aldosterone concentrations, sodium transport is predicted to be controlled by MR occupancy during circadian cycles and by MR and GR occupancy during salt restriction or acute stress...
  74. ncbi A mutation in the cofactor-binding domain of 11beta-hydroxysteroid dehydrogenase type 2 associated with mineralocorticoid hypertension
    A Odermatt
    Division of Nephrology and Hypertension, Inselspital, University of Berne, 3010 Berne, Switzerland
    J Clin Endocrinol Metab 86:1247-52. 2001
    ....
  75. pmc A genetic defect resulting in mild low-renin hypertension
    R C Wilson
    Pediatric Endocrinology, The New York Hospital Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:10200-5. 1998
    ..Because approximately 40% of patients with essential hypertension demonstrate low renin, we suggest that such patients should undergo genetic analysis of the HSD11B2 gene...
  76. pmc Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium
    Sung Huhn Kim
    Kansas State Univ, Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506 5802, USA
    Am J Physiol Cell Physiol 296:C544-57. 2009
    ..These results provide an understanding and a molecular definition of an important transport function of Reissner's membrane epithelium in the homeostasis of cochlear endolymph...
  77. ncbi Alteration of the activity of the 11beta-hydroxysteroid dehydrogenase in pregnancy: relevance for the development of pregnancy-induced hypertension?
    P Heilmann
    Department of Internal Medicine I Endocrinology and Metabolism, University of Heidelberg, D 69115 Heidelberg, Germany
    J Clin Endocrinol Metab 86:5222-6. 2001
    ..Whether the ratio of urinary free cortisol to free cortisone is a useful risk factor for the development of PIH must be investigated in further prospective studies...
  78. ncbi Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response
    Karen E Chapman
    Endocrinology Unit, Centre for Cardiovascular Sciences, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Ann N Y Acad Sci 1088:265-73. 2006
    ..These findings suggest 11beta-HSD1 may be a component of mechanisms engaged early during the inflammatory response that promote its subsequent resolution...
  79. ncbi Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome
    Bruno Vogt
    Division of Nephrology and Hypertension, University Hospital of Berne, Inselspital, Berne, Switzerland
    Nephrol Dial Transplant 17:753-8. 2002
    ..We hypothesize that this mechanism is a reduced 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) activity, a phenomenon known to cause enhanced access of cortisol or corticosterone to the mineralocorticoid receptor...
  80. ncbi Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone
    M S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Bone 27:375-81. 2000
    ..In particular, variation in 11beta-HSD isozyme expression and activity may explain individual variation in susceptibility to glucocorticoid-induced osteoporosis...
  81. ncbi The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension
    S H van Uum
    Department of Medicine, St Radboud University Hospital, University of Nijmegen, Netherlands
    Cardiovasc Res 38:16-24. 1998
    ..Finally, in the placenta 11 beta-HSD2 reduces fetal exposure to maternal glucocorticoids and a decreased activity of this isozyme may result in low birth weight and increased risk of high blood pressure at adult age...
  82. ncbi Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2
    E Lovati
    Department of Nephrology and Hypertension, University of Berne, Switzerland
    J Clin Endocrinol Metab 84:3745-9. 1999
    ..The association of a polymorphic microsatellite marker of the gene with a reduced 11betaHSD2 activity suggests that variants of the HSD 11B2 gene contribute to enhanced blood pressure response to salt in humans...
  83. ncbi The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
    A Odermatt
    Division of Nephrology, Department of Medicine, University of Berne, 3010 Berne, Switzerland
    J Biol Chem 274:28762-70. 1999
    ..Our results emphasize the importance of the N-terminal transmembrane segments of 11beta-HSD enzymes for their proper function and demonstrate that they are sufficient to determine their orientation in the ER membrane...
  84. ncbi Role of 11beta-hydroxysteroid dehydrogenase 2 renal activity in potassium homeostasis in rats with chronic renal failure
    N L Yeyati
    Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina
    Braz J Med Biol Res 43:52-6. 2010
    ..This adaptation may be mediated by renal 11beta-HSD2 activity, which, when normalized for GFR, became similar to that of control rats, suggesting that mineralocorticoid receptors maintain their aldosterone selectivity...
  85. ncbi 11Beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in human fetal development
    G Hirasawa
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 84:1453-8. 1999
    ....
  86. ncbi Apparent mineralocorticoid excess syndrome: an overview
    Mario Palermo
    Institute of Endocrinology, University of Sassari, Sassari, Italy
    Arq Bras Endocrinol Metabol 48:687-96. 2004
    ..Substrate excess as seen in Cushing's syndrome and ACTH ectopic production can overwhelm the capacity of 11beta-HSD2 to convert F to E, leading up to an acquired form of AME...
  87. pmc Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2
    R W Brown
    University Department of Medicine, Western General Hospital, Edinburgh, Scotland, UK
    Biochem J 313:1007-17. 1996
    ..11 beta-HSD2 transcripts are expressed in fetal kidney (but not lung, liver or brain) at 21-26 weeks, suggesting that an 11 beta-HSD2 distribution resembling that in the adult is established by this stage in human development...
  88. ncbi Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen, Germany
    Steroids 74:742-5. 2009
    ..The aim of the present study was to investigate whether UFF and UFE excretion is also affected by urine volume in severely obese subjects...
  89. ncbi Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patients
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy
    J Hypertens 26:486-93. 2008
    ....
  90. ncbi Chronic maternal hypertension affects placental gene expression and differentiation in rabbits
    Adelle McArdle
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Hypertens 28:959-68. 2010
    ..Previously, we have shown that adult offspring from hypertensive rabbits develop hypertension...
  91. ncbi 11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages
    R Thieringer
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Immunol 167:30-5. 2001
    ..In summary, we have shown strong expression of 11beta-HSD1 in cultured human macrophages and THP-1 cells. The presence of the enzyme in these cells suggests that it may play a role in regulating the immune function of these cells...
  92. pmc Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function
    Aihua Hu
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Physiol Lung Cell Mol Physiol 296:L790-803. 2009
    ....
  93. ncbi Mineralocorticoid receptors: distribution and activation
    John W Funder
    Prince Henry s Institute of Medical Research, Clayton 3168, Victoria, Australia
    Heart Fail Rev 10:15-22. 2005
    ..Its wider (patho)physiologic implications, particularly for neurobiology, remain to be explored...
  94. ncbi Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats
    Morag J Young
    P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2622-8. 2010
    ....
  95. ncbi Cortisol metabolism in depressed patients and healthy controls
    Benedikt Römer
    Central Institute of Mental Health, J5, Mannheim, Germany
    Neuroendocrinology 90:301-6. 2009
    ....
  96. ncbi High dietary potassium chloride intake augments rat renal mineralocorticoid receptor selectivity via 11beta-hydroxysteroid dehydrogenase
    J J Hermans
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochim Biophys Acta 1472:537-49. 1999
    ..This may contribute to the fine-tuning of salt-water homeostasis by the kidney...
  97. ncbi Increased expression of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 2 in human atria during atrial fibrillation
    Pei De-An
    Division of Cardiology, Hangzhou Red Cross Hospital, Hangzhou, China
    Clin Cardiol 33:23-9. 2010
    ..It is not clear whether the expression of a mineralocorticoid receptor (MR), or 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), conferring aldosterone specificity to the MR, in patients with AF is altered...
  98. ncbi [A 87-year-old woman with mineralocorticoid excess due to 11 beta-HSD2 deficiency]
    Mitsuo Inada
    Kizuyabashitakeda Hospital, Japan
    Nihon Ronen Igakkai Zasshi 44:513-6. 2007
    ..Recently, elderly patients with 11 beta-HSD2 deficiency are often reported, therefore further investigations in relation to the changes caused by aging are needed to elucidate this abnormality...
  99. ncbi 11Beta-hydroxysteroid dehydrogenase in the Dahl rat
    R Franco-Saenz
    Department of Medicine, Medical College of Ohio, Toledo, 43699, USA
    Am J Hypertens 10:1004-9. 1997
    ..These findings suggest that diminished activity of both liver and kidney 11beta-HSD1 may play a role in the salt sensitivity and development of hypertension in the Dahl-S rat...
  100. ncbi Impact of dietary Na+ on glycyrrhetinic acid-like factors (kidney 11beta-(HSD2)-GALFs) in human essential hypertension
    D J Morris
    Department of Pathology and Laboratory Medicine, The Miriam Hospital, Brown University School of Medicine, Providence, RI 02906, USA
    Hypertension 31:469-72. 1998
    ..The greater response of the high/normal-renin essential hypertensive subjects indicated that they may utilize kidney 11beta(HSD2)-GALFs when challenged with a low-Na+ diet, whereas the low-renin essential hypertensive subjects do not...
  101. pmc Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring
    M J Nyirenda
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Invest 101:2174-81. 1998
    ..Programmed hepatic PEPCK overexpression, perhaps mediated by increased GR, may promote this process by increasing gluconeogenesis...

Research Grants18

  1. ANDROGEN METABOLISM IN CHILDHOOD
    Maria New; Fiscal Year: 2006
    ..6) The harmonious interaction of molecular geneticists, biochemists, psychoendocrinologists, and clinicians with great experience in dealing with patients. ..
  2. ENDOTHELIAL DERIVED STEROID SIGNALS AND TISSUE STRUCTURE
    SIMON SLIGHT; Fiscal Year: 2002
    ..Specific Aim number 4: to (A) measure endothelias- derived progesterone and progesterone metabolites and (B) study their paracrine modulation of fibroblast 11 beta-HSD activity and collagen turnover using co-culture methodology. ..
  3. IUGR Affects Renal 11?-HSD2 Epigenetic Characteristics
    Mariana Baserga; Fiscal Year: 2009
    ..Ultimately, these studies will provide a basis for potential dietary and/or specific pharmacological interventions that can reverse or moderate the epigenetic alterations underlying decreased kidney 11[unreadable]-HSD2. ..
  4. Adrenal decommissioning and hypertension
    Elise Gomez Sanchez; Fiscal Year: 2007
    ..Using similar protocols as those in Aim 1, we will study and compare the process of adrenal decommissioning between SHR-SP and regular SHR rats with emphasis of the ZG genes identified as important in Aim 1. ..
  5. ALDOSTERONE, HYPERTENSION AND THE BRAIN
    Elise Gomez Sanchez; Fiscal Year: 2003
    ..4) Study of the metabolism of aldosterone and corticosterone and the regulation of the synthesis of low polarity derivatives in the brain, including the identification of the sites of formation of aldosterone acyl esters. ..
  6. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  7. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  8. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  9. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  10. Maternal Programming of Gene Expression Through DNA Methylation
    MICHAEL JOSEPH MEANEY; Fiscal Year: 2010
    ..abstract_text> ..
  11. Treatment of Endometriosis with NA vs GnRH Agonist
    Ozgul Muneyyirci Delale; Fiscal Year: 2008
    ..The objectives will be compared between the group at 12, 24 and 52 weeks of treatment and at 6 month intervals during the follow-up period. ..
  12. Prenatal and Perinatal Programming of Adult Hypertension
    VESA VEHASKARI; Fiscal Year: 2006
    ..The effect of short-term postnatal dietary and phamacological manipulations on the long-term blood pressure profile will be investigated. ..
  13. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  14. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
  15. Individual Differences in Mesolimbic Dopamine Systems
    Michael Meaney; Fiscal Year: 2003
    ..We feel that these studies will provide us with an understanding of the way in which early environmental events might contribute to the development of individual differences in neural systems that mediate drug-seeking behavior. ..
  16. The Role of Osteocyte Survival in Bone Strength
    Robert Weinstein; Fiscal Year: 2005
    ..The proposed research plan will reveal the role of osteocyte survival in bone strength and how osteocytes achieve this objective. ..
  17. Individual differences in maternal behavior in the rat
    Michael Meaney; Fiscal Year: 2007
    ..abstract_text> ..
  18. NaCI Balance and Targeted Insulin Receptor Knockout Mice
    Carolyn Ecelbarger; Fiscal Year: 2004
    ..Overall, we believe these models will provide fresh molecular insight into a physiological phenomenon that has been known for decades, insulin induced hypertension, with clear clinical ramifications. ..