Genomes and Genes
Summary: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Publications437 found, 100 shown here
- Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM)Tiziana Anelli
Universita Vita Salute San Raffaele, Milano, Italy
Antioxid Redox Signal 16:1077-87. 2012..How these multiple functions are integrated with one another in living cells remains unclear...
- The influence of soil pH on the diversity, abundance and transcriptional activity of ammonia oxidizing archaea and bacteriaGraeme W Nicol
Institute of Biological and Environmental Science, University of Aberdeen, Cruickshank Building, Aberdeen, UK
Environ Microbiol 10:2966-78. 2008..They also suggest that both groups of ammonia oxidizers have distinct physiological characteristics and ecological niches, with consequences for nitrification in acid soils...
- Novel genes for nitrite reductase and Amo-related proteins indicate a role of uncultivated mesophilic crenarchaeota in nitrogen cyclingAlexander H Treusch
University of Bergen, Department of Biology, Jahnebakken 5, N 5020 Bergen, Norway
Environ Microbiol 7:1985-95. 2005..Taken together, our findings suggest that mesophilic terrestrial and marine crenarchaeota might be capable of ammonia oxidation under aerobic and potentially also under anaerobic conditions...
- Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activityTomáš Werner
Institute of Biology Applied Genetics, Freie Universitat Berlin, 14195 Berlin, Germany
Plant Cell 15:2532-50. 2003....
- The emerging role for bacteria in lignin degradation and bio-product formationTimothy D H Bugg
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
Curr Opin Biotechnol 22:394-400. 2011..If biocatalytic routes for lignin breakdown could be developed, then lignin represents a potentially rich source of renewable aromatic chemicals...
- Oxidative protein folding in eukaryotes: mechanisms and consequencesBenjamin P Tu
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
J Cell Biol 164:341-6. 2004..How Ero1p distinguishes between the many different PDI-related proteins and how the cell minimizes the effects of oxidative damage from Ero1 remain important open questions...
- Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidaseCelio X C Santos
Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, CEP 05403 000, Sao Paulo, Brazil
Antioxid Redox Signal 11:2409-27. 2009..mechanisms of ROS generation during UPR include: (a) Multiple thiol-disulfide exchanges involving ER oxidoreductases including flavooxidase Ero1 and protein disulfide isomerase (PDI); (b) Mitochondrial electron transport; (c) ..
- Growth, activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosmsMaria Tourna
School of Biological Sciences, University of Aberdeen, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, UK
Environ Microbiol 10:1357-64. 2008..The findings suggest a role for crenarchaea in soil nitrification and that further information is required on their biogeography...
- Arabidopsis mutants define a central role for the xanthophyll cycle in the regulation of photosynthetic energy conversionK K Niyogi
Carnegie Institution of Washington, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA
Plant Cell 10:1121-34. 1998....
- Ceramide synthases: roles in cell physiology and signalingJohnny Stiban
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Adv Exp Med Biol 688:60-71. 2010..Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease...
- Relative abundance and diversity of ammonia-oxidizing archaea and bacteria in the San Francisco Bay estuaryAnnika C Mosier
Department of Environmental Earth System Science, Stanford University, Stanford, CA 94305, USA
Environ Microbiol 10:3002-16. 2008..Overall, this study significantly enhances our understanding of estuarine ammonia-oxidizing microbial communities and highlights the environmental conditions and niches under which different AOA and beta-AOB phylotypes may thrive...
- Coordinating assembly and export of complex bacterial proteinsRachael L Jack
School of Biological Sciences, University of East Anglia, Norwich, UK
EMBO J 23:3962-72. 2004..It is proposed that some Tat signal peptides operate in tandem with cognate binding chaperones to orchestrate the assembly and transport of complex enzymes...
- Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymesK L Kavanagh
Structural Genomics Consortium, University of Oxford, United Kingdom
Cell Mol Life Sci 65:3895-906. 2008Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms...
- Activity, abundance and diversity of nitrifying archaea and bacteria in the central California CurrentAlyson E Santoro
Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Environ Microbiol 12:1989-2006. 2010..Using an isotope mass balance model, we calculate that nitrification could produce between 0.45 and 2.93 micromol m(-2) day(-1) N(2)O in the central California Current, or approximately 1.5-4 times the local N(2)O flux from deep water...
- Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leavesJochen Bogs
Commonwealth Scientific and Industrial Research Organization, Plant Industry, Horticulture Unit, Glen Osmond, South Australia
Plant Physiol 139:652-63. 2005..Both ANR and LAR contribute to PA synthesis in fruit, and the tissue and temporal-specific regulation of the genes encoding ANR and LAR determines PA accumulation and composition during grape berry development...
- Evolutionary origins and functions of the carotenoid biosynthetic pathway in marine diatomsSacha Coesel
Cell Signalling Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples, Italy
PLoS ONE 3:e2896. 2008....
- Ammonia-oxidizing archaea: important players in paddy rhizosphere soil?Xue Ping Chen
Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
Environ Microbiol 10:1978-87. 2008..These results show that AOA is dominant in the rhizosphere paddy soil in this study, and we assume that AOA were influenced more by exudation from rice root (e.g. oxygen, carbon dioxide) than AOB...
- Improvement in the RFLP procedure for studying the diversity of nifH genes in communities of nitrogen fixers in soilF Poly
Laboratoire d Ecologie Microbienne, UMR CNRS 5557, UCB Lyon 1, Villeurbanne, France
Res Microbiol 152:95-103. 2001..Pure strain profiles could not be recognized in the nifH soil patterns. Using the simple procedure described, it was shown that the structure of nitrogen fixers in soil was influenced by soil functioning...
- Functional in vitro analysis of the ERO1 protein and protein-disulfide isomerase pathwayKazutaka Araki
Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
J Biol Chem 286:32705-12. 2011..the ERO1-PDI pathway was demonstrated by functional in vitro complementation assays using yeast and mammalian oxidoreductases. Finally, the results provide experimental evidence for the intramolecular electron transfer from the a ..
- The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stressSeema Chakravarthi
The Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
EMBO Rep 7:271-5. 2006..In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress...
- Seasonal changes of freshwater ammonia-oxidizing archaeal assemblages and nitrogen species in oligotrophic alpine lakesJean Christophe Auguet
Centro de Estudios Avanzados de Blanes, CEAB CSIC, Accés Cala Sant Francesc 14, E 17300, Blanes, Spain
Appl Environ Microbiol 77:1937-45. 2011..This suggests that different AOA ecotypes are adapted to different temporal ecological niches in these lakes...
- ArxA, a new clade of arsenite oxidase within the DMSO reductase family of molybdenum oxidoreductasesKamrun Zargar
Departments of Microbiology and Environmental Toxicology Biomolecular Engineering, University of California Santa Cruz, CA 95064, USA
Environ Microbiol 14:1635-45. 2012..for arsenotrophy belong to distinct clades within the DMSO reductase family of molybdenum-containing oxidoreductases: specifically arsenate respiratory reductase, ArrA, and arsenite oxidase, AioA (formerly referred to as AroA ..
- Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegansXinzhu Deng
Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
Science 322:110-5. 2008....
- FOLy: an integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of lignin and related aromatic compoundsAnthony Levasseur
UMR 1163 INRA de Biotechnologie des Champignons Filamenteux, IFR86 BAIM, Universités de Provence et de la Méditerranée, ESIL, 163 Avenue de Luminy, Case Postale 925, 13288 Marseille Cedex 09, France
Fungal Genet Biol 45:638-45. 2008..Genomic comparison of the oxidoreductases of these fungi revealed significant differences in the putative enzyme arsenals...
- Nitrogenase gene diversity and microbial community structure: a cross-system comparisonJonathan P Zehr
Department of Ocean Sciences, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Environ Microbiol 5:539-54. 2003..The broad analysis of nitrogenase genes provides a basis for developing molecular assays and bioinformatics approaches for the study of nitrogen fixation in the environment...
- Archaea predominate among ammonia-oxidizing prokaryotes in soilsS Leininger
Department of Biology, University of Bergen, Jahnebakken 5, N 5020 Bergen, Norway
Nature 442:806-9. 2006..Our results indicate that crenarchaeota may be the most abundant ammonia-oxidizing organisms in soil ecosystems on Earth...
- GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activitiesD R Cavener
Department of Molecular Biology, Vanderbilt University, Nashville, TN 37235
J Mol Biol 223:811-4. 1992..that these four diverse flavoproteins are homologous, defining a new family of proteins named the GMC oxidoreductases. These enzymes contain a canonical ADP-binding beta alpha beta-fold close to their amino termini as found in ..
- Diversity of ammonium-oxidizing bacteria in a granular sludge anaerobic ammonium-oxidizing (anammox) reactorZhe Xue Quan
Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
Environ Microbiol 10:3130-9. 2008..The partial sequence of hydrazine-oxidizing enzyme (hzo) of dominant AnAOB was also identified using new designed primers. Based on this analysis, we propose to tentatively name this new AnAOB Candidatus'Jettenia asiatica'...
- Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidationKarl M Baker
Faculty of Life Sciences, University of Manchester, Manchester, UK
EMBO J 27:2988-97. 2008....
- Environmental detection of octahaem cytochrome c hydroxylamine/hydrazine oxidoreductase genes of aerobic and anaerobic ammonium-oxidizing bacteriaMarkus C Schmid
Department of Microbiology, IWWR, Radboud University Nijmegen, Nijmegen, The Netherlands
Environ Microbiol 10:3140-9. 2008..We propose that OCC protein-encoding genes are suitable targets for molecular ecological studies on both aerobic and anaerobic ammonium-oxidizing bacteria...
- Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDIKenji Inaba
Division of Protein Chemistry, Post Genome Science Center, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
EMBO J 29:3330-43. 2010..Ero1α activity ensure that not all PDIs are oxidized, its specificity towards PDI could allow other resident oxidoreductases to remain reduced and competent to carry out isomerization and reduction of protein substrates...
- Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defenseMiklos Geiszt
Department of Physiology, Semmelweis University, Faculty of Medicine, Bethesda, Maryland, USA
FASEB J 17:1502-4. 2003..Our observations suggest that Duox1 and Duox2 are novel H2O2 sources that can support LPO-mediated antimicrobial defense mechanisms on mucosal surfaces...
- Identification of a protein required for disulfide bond formation in vivoJ C Bardwell
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
Cell 67:581-9. 1991..protein containing the sequence cys-pro-his-cys, which resembles the active sites of certain disulfide oxidoreductases. The purified DsbA protein is capable of reducing the disulfide bonds of insulin, an activity that it shares ..
- Short-chain dehydrogenases/reductases (SDR)H Jornvall
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Biochemistry 34:6003-13. 1995..Short-chain dehydrogenases illustrate the value of comparisons and diversified research in generating unexpected discoveries...
- Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNAGregory J Tanner
CSIRO Plant Industry, GPO Box 1600, Canberra, Australian Capital Territory 2601, Australia
J Biol Chem 278:31647-56. 2003..This may be because Arabidopsis seems to produce only an epicatechin, rather than a dual catechin/epicatechin-based PA similar to many other plants...
- Pathways of carbon assimilation and ammonia oxidation suggested by environmental genomic analyses of marine CrenarchaeotaSteven J Hallam
Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS Biol 4:e95. 2006..These findings further substantiate the likely global metabolic importance of Crenarchaeota with respect to key steps in the biogeochemical transformation of carbon and nitrogen in marine ecosystems...
- Arsenic and selenium in microbial metabolismJohn F Stolz
Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
Annu Rev Microbiol 60:107-30. 2006..This review highlights recent advances in ecology, biochemistry, and molecular biology and provides a prelude to the impact of genomics studies...
- When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesisYael Pewzner-Jung
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
J Biol Chem 281:25001-5. 2006
- GILT is a critical host factor for Listeria monocytogenes infectionReshma Singh
Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250 8011, USA
Nature 455:1244-7. 2008..In addition, purified GILT activates recombinant LLO, facilitating membrane permeabilization and red blood cell lysis. The data show that GILT is a critical host factor that facilitates L. monocytogenes infection...
- Environmental factors shaping the ecological niches of ammonia-oxidizing archaeaTuba H Erguder
Laboratory of Microbial Ecology and Technology LabMET, Gent University, Gent, Belgium
FEMS Microbiol Rev 33:855-69. 2009..It is proposed that the AOA might be important actors within the nitrogen cycle in low-nutrient, low-pH, and sulfide-containing environments...
- A comparison of primer sets for detecting 16S rRNA and hydrazine oxidoreductase genes of anaerobic ammonium-oxidizing bacteria in marine sedimentsMeng Li
Division of Microbiology, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, People s Republic of China
Appl Microbiol Biotechnol 86:781-90. 2010..Results indicated a broad distribution of anammox bacteria with high niche-specific community structure within each marine ecosystem...
- Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistanceWilliam L Holland
Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
Cell Metab 5:167-79. 2007..Second, they identify enzymes required for ceramide synthesis as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy...
- Major gradients in putatively nitrifying and non-nitrifying Archaea in the deep North AtlanticHélène Agogué
Department of Biological Oceanography, Royal Netherlands Institute for Sea Research Royal NIOZ, PO Box 59, 1790 AB Den Burg, Texel, The Netherlands
Nature 456:788-91. 2008....
- Thioredoxin and glutaredoxin systemsA Holmgren
Department of Physiological Chemistry, Karolinska Institute, Stockholm, Sweden
J Biol Chem 264:13963-6. 1989
- Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamiliesJ A Gerlt
Departments of Biochemistry and Chemistry, University of Illinois, Urbana, Illinois 61801, USA
Annu Rev Biochem 70:209-46. 2001....
- The mcrA gene as an alternative to 16S rRNA in the phylogenetic analysis of methanogen populations in landfillPhilip E Luton
Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Microbiology 148:3521-30. 2002..Analysis revealed a far greater diversity in the methanogen population within landfill material than has been seen previously...
- Biodegradation of lignocellulosics: microbial, chemical, and enzymatic aspects of the fungal attack of ligninAngel T Martinez
Biological Research Center, CSIC, Madrid, Spain
Int Microbiol 8:195-204. 2005..degradation and modification of the lignin polymer are reviewed, as are the different oxidative enzymes (oxidoreductases) involved in lignin degradation...
- Understanding how the distal environment directs reactivity in chlorite dismutase: spectroscopy and reactivity of Arg183 mutantsBéatrice Blanc
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
Biochemistry 51:1895-910. 2012..Current evidence is most consistent with a conformational adjustment of Arg183. A properly oriented Arg183 is critical for the stabilization of anions in the distal pocket and for efficient catalysis...
- Screening of basidiomycete fungi for the quinone-dependent sugar C-2/C-3 oxidoreductase, pyranose dehydrogenase, and properties of the enzyme from Macrolepiota rhacodesJ Volc
Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
Arch Microbiol 176:178-86. 2001..The N-terminal sequence, AVVYRHPDEL, showed significant similarity with that reported for A. bisporus...
- N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activitiesStephane Uroz
Interactions Plantes et Micro organismes de la Rhizosphère, Institut des Sciences du Vegetal, CNRS, Batiment 23, 91198 Gif sur Yvette Cedex, France
Microbiology 151:3313-22. 2005..R. erythropolis is therefore capable of modifying and degrading AHL signal molecules through both oxidoreductase and amidolytic activities...
- Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cellsShunji Nakayama
Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Cancer Sci 99:1370-6. 2008..These findings suggest that down-modulation of Wwox expression is an early event and may be associated with the down-regulation of Smad4 protein levels during pancreatic duct carcinogenesis...
- Reconstitution of human Ero1-Lalpha/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomeraseLei Wang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
J Biol Chem 284:199-206. 2009..These data, combined with a pull-down assay and isothermal titration calorimetry measurements, enabled the minimal element for binding with Ero1-Lalpha to be mapped to the b'xa' fragment of hPDI...
- Contribution of crenarchaeal autotrophic ammonia oxidizers to the dark primary production in Tyrrhenian deep waters (Central Mediterranean Sea)Michail M Yakimov
Laboratory of Marine Molecular Microbiology, Institute for Coastal Marine Environment, CNR, Messina, Italy
ISME J 5:945-61. 2011....
- Redox thermodynamics of high-spin and low-spin forms of chlorite dismutases with diverse subunit and oligomeric structuresStefan Hofbauer
Department of Chemistry, Division of Biochemistry, VIBT Vienna Institute of BioTechnology, BOKU University of Natural Resources and Life Sciences, A 1190 Vienna, Austria
Biochemistry 51:9501-12. 2012Chlorite dismutases (Clds) are heme b-containing oxidoreductases that convert chlorite to chloride and dioxygen...
- Methionine sulfoxide reductases in prokaryotesBenjamin Ezraty
Laboratoire de Chimie Bacterienne, Institut Fédératif de Recherche Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
Biochim Biophys Acta 1703:221-9. 2005....
- Nodulation of Sesbania species by Rhizobium (Agrobacterium) strain IRBG74 and other rhizobiaStephen P Cummings
School of Applied Sciences, Ellison Building, University of Northumbria, Newcastle upon Tyne, UK
Environ Microbiol 11:2510-25. 2009..These data are discussed in terms of the molecular phylogeny of Sesbania and its symbionts...
- Was nitric oxide the first deep electron sink?Anne Lise Ducluzeau
Laboratoire de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique UPR9036, IFR77, Marseille Cedex 20, France
Trends Biochem Sci 34:9-15. 2009..Aerobic respiration emerged later from within this ancestral pathway via adaptation of the enzyme NO reductase to its new substrate, dioxygen...
- Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancerCeren G Korkmaz
Department of Molecular Biosciences, University of Oslo, Postboks 1050 Blindern, 0316 Oslo, Norway
Oncogene 24:4934-45. 2005..Taken together, these data suggest that STAMP2 may contribute to the normal biology of the prostate cell, as well as prostate cancer progression...
- Cytokinin oxidase regulates rice grain productionMotoyuki Ashikari
Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
Science 309:741-5. 2005..QTL pyramiding to combine loci for grain number and plant height in the same genetic background generated lines exhibiting both beneficial traits. These results provide a strategy for tailormade crop improvement...
- Isolation of an autotrophic ammonia-oxidizing marine archaeonMartin Könneke
Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, USA
Nature 437:543-6. 2005..The autotrophic metabolism of this isolate, and its close phylogenetic relationship to environmental marine crenarchaeal sequences, suggests that nitrifying marine Crenarchaeota may be important to global carbon and nitrogen cycles...
- Unexpected diversity of chlorite dismutases: a catalytically efficient dimeric enzyme from Nitrobacter winogradskyiGeorg Mlynek
Department for Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, A 1030 Vienna, Austria
J Bacteriol 193:2408-17. 2011..Interestingly, proteins that contain all these signatures and are phylogenetically closely related to the novel-type Cld of N. winogradskyi exist in a large number of other microbes, including other nitrite oxidizers...
- Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegansRansome van der Hoeven
Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS Pathog 7:e1002453. 2011..Overall, a model is presented in which ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling...
- Ammonia-oxidizing bacterial community composition in estuarine and oceanic environments assessed using a functional gene microarrayBess B Ward
Department of Geosciences, Guyot Hall, Princeton University, Princeton, NJ, USA
Environ Microbiol 9:2522-38. 2007....
- Stereocomplementary bioreduction of alpha,beta-unsaturated dicarboxylic acids and dimethyl esters using enoate reductases: enzyme- and substrate-based stereocontrolClemens Stueckler
Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
Org Lett 9:5409-11. 2007..Cofactor-recycling systems (NADH/FDH/formate, NADH/GDH/glucose or NADPH/G6PDH/glucose-6-phosphate) only worked in presence of a divalent metal ion, such as Ca2+, Mg2+, or Zn2+...
- Ammonia oxidation and ammonia-oxidizing bacteria and archaea from estuaries with differing histories of hypoxiaJane M Caffrey
Center for Environmental Diagnostics and Bioremediation, University of West Florida, Pensacola, FL, USA
ISME J 1:660-2. 2007..This suggests that AOA are significant in estuarine nitrogen cycling. Surprisingly, more of the variability in potential nitrification rates was predicted by salinity and pore water sulfide than by dissolved oxygen history...
- Denaturing gradient gel electrophoresis (DGGE) approaches to study the diversity of ammonia-oxidizing bacteriaMette Haubjerg Nicolaisen
Department of Microbial Ecology, Institute of Biological Sciences, University of Aarhus, Ny Munkegade, Building 540, DK 8000 C, Aarhus, Denmark
J Microbiol Methods 50:189-203. 2002..The majority of retrieved sequences from all four habitats with high ammonia loads were Nitrosomonas-like and only few Nitrosospira-like sequences were detected...
- Shall we dance? How a multicopper oxidase chooses its electron transfer partnerLiliana Quintanar
Centro de Investigacion y de Estudios Avanzados, Mexico, D F, Mexico
Acc Chem Res 40:445-52. 2007....
- Shifts in the relative abundance of ammonia-oxidizing bacteria and archaea across physicochemical gradients in a subterranean estuaryAlyson E Santoro
Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305, USA
Environ Microbiol 10:1068-79. 2008..These results offer new insights into the ecology of AOA and beta-AOB by elucidating conditions that may favour the numerical dominance of beta-AOB over AOA in coastal sediments...
- Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteinsJ Moskovitz
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110 1199, USA
Proc Natl Acad Sci U S A 93:2095-9. 1996..This is consistent with the observation that kidney extracts also contained the highest level of enzyme activity...
- Critical residues for structure and catalysis in short-chain dehydrogenases/reductasesCharlotta Filling
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Biol Chem 277:25677-84. 2002..This extends the previously recognized catalytic triad of Ser-Tyr-Lys residues to form a tetrad of Asn-Ser-Tyr-Lys in the majority of characterized short-chain dehydrogenases/reductase enzymes...
- Ethnic variation in tyrosinase and TYRP1 expression in photoexposed and photoprotected human skinSimon Alaluf
Unilever Research, Colworth Laboratory, Sharnbrook, Bedford, UK
Pigment Cell Res 16:35-42. 2003..Moreover, the observed ethnic variation in TYRP1 protein expression suggests that TYRP1 may play a significant role in mediating ethnic differences in melanogenesis and constitutive skin pigmentation in vivo...
- Membrane-bound diiron carboxylate proteinsDeborah A Berthold
Department of Biochemistry and Biophysics, Arrhenius Laboratory for Natural Sciences, Stockholm University, Svante Arrhenius vag 12, SE 106 91 Stockholm, Sweden
Annu Rev Plant Biol 54:497-517. 2003..We discuss what is known about each enzyme as well as our expectations based on their identification as interfacially bound proteins with a diiron carboxylate active site...
- Methane as fuel for anaerobic microorganismsRudolf K Thauer
Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
Ann N Y Acad Sci 1125:158-70. 2008..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
- Global occurrence of archaeal amoA genes in terrestrial hot springsChuanlun L Zhang
Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
Appl Environ Microbiol 74:6417-26. 2008..Our study demonstrates the global occurrence of putative archaeal amoA genes in a wide variety of terrestrial hot springs and suggests that geography may play an important role in selecting different assemblages of AOA...
- Genes and enzymes involved in bacterial oxidation and reduction of inorganic arsenicSimon Silver
Department of Microbiology and Immunology, MC790, University of Illinois, 835 S Wolcott Ave, Chicago, IL 60612 7344, USA
Appl Environ Microbiol 71:599-608. 2005
- Molecular and biogeochemical evidence for ammonia oxidation by marine Crenarchaeota in the Gulf of CaliforniaJ Michael Beman
Department of Geological and Environmental Sciences, Stanford University, Stanford, CA, USA
ISME J 2:429-41. 2008..90, P<0.001), and with 16S rRNA gene copies from marine Crenarchaeota (r2=0.85, P<0.005). These findings represent compelling evidence for an archaeal role in oceanic nitrification...
- Archaea dominate the ammonia-oxidizing community in the rhizosphere of the freshwater macrophyte Littorella unifloraMartina Herrmann
Department of Biological Sciences, Microbiology, University of Aarhus, Ny Munkegade, Building 1540, DK 8000 Aarhus C, Denmark
Appl Environ Microbiol 74:3279-83. 2008....
- Environmental genomics reveals a functional chlorite dismutase in the nitrite-oxidizing bacterium 'Candidatus Nitrospira defluvii'Frank Maixner
Department für Mikrobielle Okologie, Universitat Wien, Vienna, Austria
Environ Microbiol 10:3043-56. 2008....
- Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotesEva Biegel
Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt, Germany
Cell Mol Life Sci 68:613-34. 2011..The energetics of the complex and its biochemistry, as well as its evolution and cellular function in different microbes, is discussed...
- Multiple ways to make disulfidesNeil J Bulleid
Institute of Molecular, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Trends Biochem Sci 36:485-92. 2011..Here we discuss these various pathways for disulfide formation in the mammalian ER and highlight the central role played by glutathione in regulating this process...
- Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coliD F Ackerley
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Appl Environ Microbiol 70:873-82. 2004..The results nevertheless suggest that YieF may be an even more suitable candidate for further studies than ChrR...
- Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78Diego Martinez
US DOE Joint Genome Institute, Walnut Creek, California 94598, USA
Nat Biotechnol 22:695-700. 2004..This genome provides a high quality draft sequence of a basidiomycete, a major fungal phylum that includes important plant and animal pathogens...
- Nitrification in terrestrial hot springs of Iceland and KamchatkaLaila J Reigstad
Department of Biology, Center for Geobiology, University of Bergen, Bergen, Norway
FEMS Microbiol Ecol 64:167-74. 2008..Our data provide evidence for an active role of archaea in nitrification of hot springs in a wide range of pH values and at a high temperature...
- Spatial distribution of Bacteria and Archaea and amoA gene copy numbers throughout the water column of the Eastern Mediterranean SeaDaniele De Corte
Department of Biological Oceanography, Royal Netherlands Institute for Sea Research NIOZ, Den Burg, The Netherlands
ISME J 3:147-58. 2009..Hence, the archaeal community in the Eastern Mediterranean Sea appears to be highly stratified despite the absence of major temperature and density gradients between the meso- and bathypelagic waters of the Mediterranean Sea...
- Population ecology of nitrifying archaea and bacteria in the Southern California BightJ Michael Beman
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
Environ Microbiol 12:1282-92. 2010..These data capture a dynamic nitrogen cycle in which multiple microbial groups appear to be active participants...
- Defective antigen processing in GILT-free miceM Maric
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Science 294:1361-5. 2001..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail...
- Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological functionHerbert Weissbach
Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA
Arch Biochem Biophys 397:172-8. 2002..There is growing evidence that MsrA plays an important role in protecting cells against oxidative damage. This paper reviews the biochemical properties and biological role of MsrA...
- Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesisH R Waterham
Department of Pediatrics, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
Am J Hum Genet 69:685-94. 2001..helix, and is a member of a recently defined family of flavin adenine dinucleotide (FAD)-dependent oxidoreductases. Conversion of desmosterol to cholesterol by DHCR24 in vitro is strictly dependent on reduced nicotinamide ..
- Crystal structure of a laccase from the fungus Trametes versicolor at 1.90-A resolution containing a full complement of coppersKlaus Piontek
Institute of Biochemistry, Swiss Federal Institute of Technology ETH, ETH Honggerberg, Building HPM, Room D 8 1 2, CH 8093 Zurich, Switzerland
J Biol Chem 277:37663-9. 2002..Based on the present structural data and sequence comparisons, a mechanism is presented to explain how laccases could tune their redox potential by as much as 200 mV...
- The Steap proteins are metalloreductasesRobert S Ohgami
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Blood 108:1388-94. 2006..Finally, the pattern of tissue expression and subcellular localization of these proteins suggest they are physiologically relevant cupric reductases and ferrireductases in vivo...
- Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cellsEmanuela Matteucci
Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, University of Milan, Italy
Carcinogenesis 30:937-45. 2009..Wwox/Met system can be suggested as a potential target to impair breast carcinoma progression...
- Involvement of an alternative oxidase in oxidative stress and mycelium-to-yeast differentiation in Paracoccidioides brasiliensisVicente P Martins
Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av Café, S N, 14040 903 Ribeirao Preto, Sao Paulo, Brazil
Eukaryot Cell 10:237-48. 2011..brasiliensis...
- Oxygen activation in flavoprotein oxidases: the importance of being positiveGiovanni Gadda
Department of Chemistry, Georgia State University, Atlanta, Georgia 30302 4098, United States
Biochemistry 51:2662-9. 2012..Mutagenesis has disclosed nonpolar sites in O(2)-reducing enzymes that utilize copper/TPQ or iron. It is predicted that classes of O(2)-reducing enzymes utilizing other cofactors also contain a similar catalytic motif...
- TaCKX6-D1, the ortholog of rice OsCKX2, is associated with grain weight in hexaploid wheatLei Zhang
College of Agronomy, Shenyang Agricultural University, Shenyang, 110866, China
New Phytol 195:574-84. 2012..Our study also sheds light on the mechanisms of grain development and domestication of wheat, as well as the functional divergence of orthologs in comparative genomics...
- Impact of subunit and oligomeric structure on the thermal and conformational stability of chlorite dismutasesStefan Hofbauer
University of Natural Resources and Life Sciences, Vienna, Austria
Biochim Biophys Acta 1824:1031-8. 2012Chlorite dismutases (Cld) are unique heme b containing oxidoreductases that convert chlorite to chloride and dioxygen...
- Understanding the roles of strictly conserved tryptophan residues in O2 producing chlorite dismutasesBéatrice Blanc
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46656, USA
Dalton Trans 42:3156-69. 2013..These observations and the lack of redox protection for the heme in any of the Trp mutants suggests a tendency for protein radical formation in DaCld that is independent of any of these conserved active site residues...
- A pH-regulated quality control cycle for surveillance of secretory protein assemblyStefano Vavassori
Division of Genetics, San Raffaele Scientific Institute, 20132 Milan, Italy
Mol Cell 50:783-92. 2013..The ERp44 assembly control cycle couples secretion fidelity and efficiency downstream of the calnexin/calreticulin and BiP-dependent quality control cycles. ..
- Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductasesKazutaka Araki
Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Koto ku, Tokyo 135 0064, Japan
J Cell Biol 202:861-74. 2013Ero1-α and endoplasmic reticulum (ER) oxidoreductases of the protein disulfide isomerase (PDI) family promote the efficient introduction of disulfide bonds into nascent polypeptides in the ER...
- Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolismThomas D Mullen
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
J Lipid Res 52:68-77. 2011..These data suggest that sphingolipid metabolism is robustly regulated by both redundancy in CerS-mediated Cer synthesis and counter-regulation of CerS expression...
- Nitric oxide-mediated maintenance of redox homeostasis contributes to NPR1-dependent plant innate immunity triggered by lipopolysaccharidesAizhen Sun
Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Plant Physiol 160:1081-96. 2012..Moreover, NPR1 plays an important role in LPS-triggered plant innate immunity...
- Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thalianaRachel Clifton
Plant Molecular Biology Group, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia
Plant Mol Biol 58:193-212. 2005..These treatment sets emphasise the multiplicity of pathways affecting alternative electron transport components in plants...
Research Grants119 found, 100 shown here
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..We therefore believe the proposed work has the potential to have a significant impact on the health care of Veterans. ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
- Paolo Fanti; Fiscal Year: 2014....
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
- Angiotensin Adrenergic Interactions in the KidneyRoland C Blantz; Fiscal Year: 2013....
- Qinghua Sun; Fiscal Year: 2015....
- ANTHONY JOHN KANAI; Fiscal Year: 2016..Hypothesis: FA-NO2 are radioprotective by desensitizing TRPA1 and TRPV1 channels and BDNF-AB and NGF-AB are therapeutic by inhibiting nerve growth and sensitization in bladder and spinal cord. ..
- Pathogenesis and Treatment of Liver Disease in Transaldolase DeficiencyAndras Perl; Fiscal Year: 2013..These studies should generate fundamental new information on the cause and treatment of potentially fatal diseases of the liver. ..
- ENEIQUE A MESRI; Fiscal Year: 2016..So our work will allow us to not only to identify mechanisms of KS carcinogenesis but also will help to identify potential new target and new drugs for anti-KS therapy. ..
- Inhibition of human neutrophil function by Francisella tularensisLee Ann H Allen; Fiscal Year: 2012..The results of this study may lead to new treatments to combat this severe and often fatal lung infection. ..
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
- Gary Cecchini; Fiscal Year: 2014..Using the SIRT3 KO mouse model, it will be determined if the properties of cardiac tissue such as pre- and post-conditioning are altered by acetylation/deacetylation of proteins. ..
- Samantha M Yeligar; Fiscal Year: 2014..Thus, this K99/R00 application provides an excellent opportunity to advance the career of a talented and promising investigator. ..
- Functional Genomics of the Mitochondrial ProteomeDennis R Winge; Fiscal Year: 2011..The function of up to 30% of the mitochondrial proteome is unknown. This proposal will elucidate the function of these un-annotated mitochondrial proteins, providing new insights into the role of mitochondria in human disease. ..
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
- Targeting Inflammation for the Amelioration of Cisplatin-Hearing LossVickram Ramkumar; Fiscal Year: 2011..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
- Mark W Chapleau; Fiscal Year: 2015..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
- Group A Streptococcus responses to oxidative stressIoannis Gryllos; Fiscal Year: 2010....
- REGULATION OF GENE EXPRESSION BY DIETARY FATLisa M Salati; Fiscal Year: 2012..This project will provide important new data on the ways in which dietary fat can regulate intracellular metabolism. ..
- Xianglin Shi; Fiscal Year: 2015..Present study attempts to identify cyanidin-3-glucoside, a plant-derived compound, as a mechanism-based preventive agent against UV-induced skin cancers. ..
- Laura L Dugan; Fiscal Year: 2014..abstract_text> ..
- ICSBP Function During Myeloid DifferentiationELIZABETH ANN EKLUND; Fiscal Year: 2011..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
- Protein Nitration in the PlacentaLeslie Myatt; Fiscal Year: 2012....
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2012..Furthermore, we anticipate this research will lead to the development of a new drug that inhibits the enzyme's activity and blocks the change of LDL. ..
- Mahin D Maines; Fiscal Year: 2015..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
- William M Nauseef; Fiscal Year: 2016..abstract_text> ..
- REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORNGirija G Konduri; Fiscal Year: 2013..These studies will identify an important new source of oxidative stress in PPHN. These observation may lead to new targeted therapies to improve vasodilation and oxygenation in PPHN. ..
- James B Martins; Fiscal Year: 2014..Similarly such drugs may be combined with other antioxidants to prevent dangerous heart rhythms. ..
- Small Molecule targeting of NADPH oxidase in neutrophilsMarie Dominique Filippi; Fiscal Year: 2010..Therefore, our study will help delivering a novel pharmaceutical target, and suitable lead compounds for the treatment of lung inflammation, such as ALI and ARDS. ..
- Arsenic Trioxide and Acute Myeloid LeukemiaYongkui Jing; Fiscal Year: 2012..Our goal will be to utilize As2O3 in combination with 4 HPR or EA analogs in clinical trials in patients with refractory, secondary or in elderly patients with acute myelogenous leukemia. ..
- Nitric Oxide in Hemodialysis AV Fistula MaturationRichard A Cohen; Fiscal Year: 2010....
- Role of Mitochondria in the Regulation of Iron metabolism by AlcoholDUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..abstract_text> ..
- X chromosome, injury and infectionZoltan Spolarics; Fiscal Year: 2012..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
- Lucy A Waskell; Fiscal Year: 2014....
- Margot S Damaser; Fiscal Year: 2014..We will explore the possibility of making this therapy noncellular to avoid complications of cell therapy. This research is of high significance for development of improved therapies for female pelvic floor disorders. ..
- Protection of Brain Injury from Cyanide Poisoning by Carnosic AcidStuart A Lipton; Fiscal Year: 2013..To investigate neuroprotective effects of CA in an in vitro model of cyanide poisoning. Specific Aim 2. To examine neuroprotective effects of CA in an in vivo mouse model mimicking the effects of cyanide ingestion. ..
- Vickram Ramkumar; Fiscal Year: 2016..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
- C Michael Hart; Fiscal Year: 2016..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
- N-Acetylcysteine and Milk Thistle for Treatment of Diabetic NephropathyPaolo Fanti; Fiscal Year: 2011..Throughout the trial, we will monitor the safety and tolerability of this combination treatment. ..
- Mechanism(s) of Alcoholic PancreatitisBhupendra S Kaphalia; Fiscal Year: 2011....
- Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and StatinsTHOMAS JAY EBERT; Fiscal Year: 2013..These studies will carefully describe the effects of glucose and statins on the function of the lining of blood vessels in humans. This new knowledge might lessen unwanted side effects related to diabetes. ..
- Biochemical Characterization of Cytochrome b5 Reductase in Candida albicansMARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010..I will also learn new techniques used in biochemistry and proteomics, such as mass spectrometry, protein pull-down assays, and other methods involved in the characterization of proteins. ..
- New therapeutics for the treatment of Acinetobactor baumannii infections.ALLEN BERNARD REITZ; Fiscal Year: 2013....
- Mechanisms of Angiogenesis in Retinopathy of PrematurityMary Elizabeth Hartnett; Fiscal Year: 2009..g., dihydroethidium);and NADPH oxidase activation. ..
- Alcohol-Induced Bone Resorption: The Role of Oxidative StressMartin J J Ronis; Fiscal Year: 2013..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
- Karen Block; Fiscal Year: 2015..This work may have major therapeutic implications. ..
- Roles of oxidation and inflammation in aortic stiffeningDavid G Harrison; Fiscal Year: 2013..Our combined expertise in the physiology of hypertension, connective tissue biochemistry and cardiovascular histomorphology place us in a unique position to pursue these directions of research. ..
- Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep ApneaBarbara J Morgan; Fiscal Year: 2013..These interventions are novel, relevant, unobtrusive, relatively inexpensive, and could drasticallv change the treatment and possible prevention of cardiovascular disease in OSA. ..
- MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2016..g., dihydroethidium);and NADPH oxidase activation. ..
- Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose MonitoringSanthisagar Vaddiraju; Fiscal Year: 2010..e. mice, rats) will provide an invaluable tool in diabetes drug development. ..
- Role of ALDH7A1 in Ethanol-Induced Oxidative DamageCHAD NICHOLAS BROCKER; Fiscal Year: 2011..This long term goal of this project is to elucidate the protective functions of ALDH7A1 during excessive alcohol consumption. ..
- Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01W Michael Foster; Fiscal Year: 2010....
- Tsung Ung W Woo; Fiscal Year: 2014..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
- Na+/H+-exchanger-1 and Diabetic NeuropathyMARK ANTHONY YOREK; Fiscal Year: 2012....
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..
- Redox regulation of phagocyte NOX2 in inflammation and agingRobert A Clark; Fiscal Year: 2013....
- ANN NARDULLI; Fiscal Year: 2014..Our studies will provide critical new information about the role of a variety of estrogens and progestins in the brain and aid in the design of more effective hormonal treatments for women of all ages. ..
- Amelioration of cisplatin ototoxicity by transplatinDebashree Mukherjea; Fiscal Year: 2010..Such a treatment could improve the quality of life of cancer patients who would otherwise face many years of poor communication because of hearing loss caused by cisplatin treatment. ..
- William M Pandak; Fiscal Year: 2016..A better understanding of cell cholesterol, fatty acid, and bile acid metabolism is crucial in order to develop more effective therapies for lipid related disorders. ..
- DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosisRuslana Bryk; Fiscal Year: 2012....
- Asthma Increases Vaso-occlusion in Sickle Cell DiseaseKirkwood A Pritchard; Fiscal Year: 2013..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
- HUA LINDA CAI; Fiscal Year: 2016..Characterization of the CMEC-cardiomyocyte signaling axis may additionally provide novel insights into potential cell-based therapies. ..
- Ke Jian Liu; Fiscal Year: 2016..Additionally, these studies may lead to testable hypotheses regarding potential arsenic targets in cancer and other arsenic-associated diseases. ..
- Yi Lu; Fiscal Year: 2016..Therefore the work will make important contributions to healthcare, as it will provide a molecular basis for understanding two enzymes important to human health. ..
- John R Hoidal; Fiscal Year: 2016..It will impact our ability to prevent or reduce the enormous medical burden caused by cigarette smoking. Nowhere is the need for new approaches with clinical application more important in pulmonary diseases than in COPD. ..
- Characterization of the thioredoxins system in the diabetic retinaFolami Lamoke; Fiscal Year: 2013..Aim 2)) Test the hypothesis that HG/diabetes induces TrxR1 protein nitration and this effect contributes to oxidative retinal endothelial cell injury. ..
- JOHN BRANNON GARY; Fiscal Year: 2014..Such findings of the biological relevance of Cu(III) would provide a complete paradigm shift in copper biochemistry (e.g. Fe(IV)-oxo intermediates for non-heme iron sites). ..
- Robert Harris; Fiscal Year: 2015..Therefore, this grant proposal is highly relevant to Veterans Health Care since colorectal cancer is estimated to claim 50,000 Veteran lives in 2010. ..
- Lee Ann H Allen; Fiscal Year: 2016....
- Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)Stephen R Wisniewski; Fiscal Year: 2013....
- JUNG JA P KIM; Fiscal Year: 2015....
- Michael Regnier; Fiscal Year: 2015..Results from these studies will provide valuable insight on whether sustained enhancement of myofilament contractility (with dATP) has potential for treatment of heart failure in animal models and humans. ..
- Xiang Fang; Fiscal Year: 2015..The proposed study will provide insight into the mechanism by which mutant CUG RNA disrupts PGC-1 activity and impair Mt function, and might lead to the development of intervention through modulating PGC-1 signaling in DM1. ..
- Saurabh Chatterjee; Fiscal Year: 2014..abstract_text> ..
- Robert J Turesky; Fiscal Year: 2014..abstract_text> ..
- Ann Richmond; Fiscal Year: 2016....
- Molecular Pathogenesis of Coenzyme Q10 DeficiencyMichio Hirano; Fiscal Year: 2012..Aim 4: In collaboration with Professor Pl[unreadable]cido Navas, University of Sevilla, Spain, we will characterize CoQ10 biosynthetic genes and mutations in yeast. ..
- KAREN TARASZKA HASTINGS; Fiscal Year: 2015..Since the effect of GILT is not limited to the presentation of TRP1 or cutaneous autoantigens, modulation of GILT expression or activity may be a broadly applied therapeutic approach for autoimmune disease. ..
- NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSISJohn W Christman; Fiscal Year: 2013..abstract_text> ..
- Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling PathwaysGrace Y Sun; Fiscal Year: 2012..These collaborative studies should identify novel strategies to control chronic inflammation and neurodegeneration in AD. ..
- Redox Triggering of Glomerular NALP3 Inflammasomes in HyperhomocysteinemiaJustine M Abais; Fiscal Year: 2013....
- Jeffrey C Rathmell; Fiscal Year: 2014....
- Targeted Degradation of DNA Damage Response Proteins by AutophagyThomas J Begley; Fiscal Year: 2013..We will perform genetic, biochemical and proteomic based experiments in S. cerevisiae to test our hypothesis and to define the molecular signals that allow autophagy to target specific proteins for degradation. ..
- Elevated Zinc in Ischemia and reperfusionYang V Li; Fiscal Year: 2013....
- Mechanisms of Early Life Stress-Induced Endothelial DysfunctionDao Ho; Fiscal Year: 2013..New investigations into how epigenetic mechanisms, especially HDACs, regulate vascular function offer an innovative direction for therapies. ..
- Shinichi Someya; Fiscal Year: 2016..Currently there is no treatment for AHL. The results of our proposal will provide the opportunity to identify interventions that will delay presbycusis in humans. ..
- SHERRY L ABBOUD-WERNER; Fiscal Year: 2016..abstract_text> ..
- Gino A Cortopassi; Fiscal Year: 2015..abstract_text> ..
- The Biological and Chemical Function of Selenium in EnzymesRobert J Hondal; Fiscal Year: 2013..Cancer cells must divide rapidly to cause pathogenesis and require increased expression of thioredoxin reductase to survive. ..
- JEFFREY BENTON HODGIN; Fiscal Year: 2014....
- Michelle R Arkin; Fiscal Year: 2014..The proposed research activity is in advance of a collaborative and longer-term lead optimization program that will continue to utilize the tools employed or developed herein. ..
- PETER WALLACE STACPOOLE; Fiscal Year: 2016....
- ADAM CARL STRAUB; Fiscal Year: 2015..abstract_text> ..
- Arjang Djamali; Fiscal Year: 2015....
- Ingo K Mellinghoff; Fiscal Year: 2016..Results of our studies will shed light on mechanisms through which an "oncometabolite" can regulate the molecular pathogenesis of cancer and refine our view of mutant IDH1 as a potential therapeutic target in human glioma. ..
- Victor J Thannickal; Fiscal Year: 2016....