ornithine decarboxylase

Summary

Summary: A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. EC 4.1.1.17.

Top Publications

  1. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
  2. ncbi Regulation of ornithine decarboxylase
    Anthony E Pegg
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 281:14529-32. 2006
  3. pmc ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 68:9735-45. 2008
  4. doi Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA
    Leo Kurian
    Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a, D 50674 Cologne, Germany
    Nature 477:490-4. 2011
  5. pmc The ornithine decarboxylase gene is essential for cell survival during early murine development
    H Pendeville
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 21:6549-58. 2001
  6. pmc Polyamines in microorganisms
    C W Tabor
    Microbiol Rev 49:81-99. 1985
  7. pmc Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model
    Shannon L Nowotarski
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:31885-94. 2010
  8. ncbi Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease
    Laura T Mäkitie
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Brain Pathol 20:571-80. 2010
  9. ncbi Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production
    C C Huang
    Tzu Hui Institute of Technology, Pingtung, Taiwan, ROC
    Apoptosis 10:895-907. 2005
  10. ncbi The antizyme family: polyamines and beyond
    Ursula Mangold
    Program in Vascular Biology, Department of Surgery, Children s Hospital, Boston, MA 02115, USA
    IUBMB Life 57:671-6. 2005

Detail Information

Publications232 found, 100 shown here

  1. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
    ..Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues...
  2. ncbi Regulation of ornithine decarboxylase
    Anthony E Pegg
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 281:14529-32. 2006
    b>Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels...
  3. pmc ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 68:9735-45. 2008
    ....
  4. doi Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA
    Leo Kurian
    Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a, D 50674 Cologne, Germany
    Nature 477:490-4. 2011
    ..Regulation of polyamine synthesis is mainly achieved by controlling the activity of ornithine decarboxylase (ODC) through an unusual mechanism involving ODC antizyme, the binding of which disrupts homodimeric ODC ..
  5. pmc The ornithine decarboxylase gene is essential for cell survival during early murine development
    H Pendeville
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 21:6549-58. 2001
    Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell ..
  6. pmc Polyamines in microorganisms
    C W Tabor
    Microbiol Rev 49:81-99. 1985
  7. pmc Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model
    Shannon L Nowotarski
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:31885-94. 2010
    b>Ornithine decarboxylase (ODC) is the first and usually rate-limiting enzyme in the polyamine biosynthetic pathway. Under normal physiological conditions, polyamine content and ODC enzyme activity are highly regulated...
  8. ncbi Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease
    Laura T Mäkitie
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Brain Pathol 20:571-80. 2010
    ..Antizyme inhibitors (AZINs) regulate the cellular uptake of polyamines and activate ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine synthesis...
  9. ncbi Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production
    C C Huang
    Tzu Hui Institute of Technology, Pingtung, Taiwan, ROC
    Apoptosis 10:895-907. 2005
    ..However, the drug resistance of MTX in malignancies remains poorly understood. Ornithine decarboxylase (ODC) plays an important role in diverse biological functions, including cell development, ..
  10. ncbi The antizyme family: polyamines and beyond
    Ursula Mangold
    Program in Vascular Biology, Department of Surgery, Children s Hospital, Boston, MA 02115, USA
    IUBMB Life 57:671-6. 2005
    ..They have been shown to inhibit cell proliferation and possess anti-tumor activity. Antizymes bind ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis...
  11. ncbi Central role for ornithine decarboxylase in beta-adrenoceptor mediated hypertrophy
    K D Schluter
    Physiologisches Institut, Justus Liebig Universitat, Giessen, Germany
    Cardiovasc Res 45:410-7. 2000
    TGF-beta stimulation of cardiac myocytes induces a hypertrophic responsiveness to beta-adrenoceptor stimulation. This study investigates whether this beta-adrenoceptor mediated effect depends on induction of ornithine decarboxylase (ODC).
  12. pmc Critical factors determining dimerization of human antizyme inhibitor
    Kuo Liang Su
    Department of Life Sciences and Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung
    J Biol Chem 284:26768-77. 2009
    b>Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine...
  13. doi Antizyme and antizyme inhibitor, a regulatory tango
    Chaim Kahana
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Cell Mol Life Sci 66:2479-88. 2009
    ..Antizymes are themselves regulated at the translational level by the level of polyamines. Antizymes bind ornithine decarboxylase (ODC) subunits and target them to ubiquitin-independent degradation by the 26S proteasome...
  14. ncbi Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase
    M Pietila
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Invest Dermatol 116:801-5. 2001
    ..the finding that doubly transgenic mice overexpressing, both spermidine/spermine N1-acetyltransferase and ornithine decarboxylase and with extremely high levels of putrescine in the skin, showed distinctly more severe skin changes ..
  15. ncbi Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism
    Sonia W Kim
    Program in Vascular Biology and Department of Surgery, Children s Hospital, Boston, MA 02115, USA
    J Cell Sci 119:2583-91. 2006
    ..binds to the regulatory protein antizyme and inhibits the ability of antizyme to interact with the enzyme ornithine decarboxylase (ODC)...
  16. ncbi Polyamine metabolism and cancer
    Thresia Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Cell Mol Med 7:113-26. 2003
    ..The biosynthetic enzymes are ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase...
  17. ncbi Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis
    O Heby
    Department of Molecular Biology, Umea University, Umea, Sweden
    Amino Acids 33:359-66. 2007
    ..Consequently, enzymes involved in spermidine synthesis and utilization, i.e. arginase, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase, trypanothione synthetase (TryS)..
  18. ncbi Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 7:433-44. 2005
    ..Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing ..
  19. ncbi Generation of destabilized green fluorescent protein as a transcription reporter
    X Li
    Laboratories, Inc, Palo Alto, California 94303, USA
    J Biol Chem 273:34970-5. 1998
    ..destabilized GFP for use in such studies by fusing amino acids 422-461 of the degradation domain of mouse ornithine decarboxylase (MODC) to the C-terminal end of an enhanced variant of GFP (EGFP)...
  20. ncbi Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
    J J Almrud
    Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA
    J Mol Biol 295:7-16. 2000
    ..b>Ornithine decarboxylase (ODC, EC 4.1.1...
  21. pmc Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
    Mingsheng Zhang
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    EMBO J 22:1488-96. 2003
    b>Ornithine decarboxylase (ODC) is regulated by its metabolic products through a feedback loop that employs a second protein, antizyme 1 (AZ1). AZ1 accelerates the degradation of ODC by the proteasome...
  22. pmc Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma
    Dana Lynn T Koomoa
    Cancer Research Center of Hawaii, Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9825-31. 2008
    b>Ornithine decarboxylase (ODC) is a key enzyme in mammalian polyamine biosynthesis that is up-regulated in various types of cancer...
  23. pmc uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologs
    Ivaylo P Ivanov
    Biosciences Institute, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 105:10079-84. 2008
    ..Here, conserved uORFs in numerous ornithine decarboxylase homologs are identified from yeast to mammals...
  24. ncbi Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes
    K Ravanko
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    Cancer Res 60:5244-53. 2000
    Cancer cells are known to display up-regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), the key enzymes in the biosynthesis of polyamines that are essential for cellular proliferation...
  25. doi Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells
    Olga A Smirnova
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str 32, 119991 Moscow, Russia
    Biochimie 94:1876-83. 2012
    ..metabolism, specifically the expression and activities of enzymes catalyzing polyamine synthesis (ornithine decarboxylase; ODC) and degradation (spermidine/spermine-N(1)-acetyltransferase; SSAT), in human hepatoma cells...
  26. ncbi Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells
    Christopher J Wallick
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Oncogene 24:5606-18. 2005
    Alpha-difluoromethylornithine (DFMO) inhibits the proto-oncogene ornithine decarboxylase (ODC) and is known to induce cell cycle arrest...
  27. pmc Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells
    Ming Fu Wang
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC
    Exp Mol Med 43:189-96. 2011
    b>Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent...
  28. ncbi Induction of gastric ornithine decarboxylase in early weaning rats
    C H Lin
    Department of Pediatrics, Wayne State University and Children s Hospital of Michigan, Detroit, Mich, USA
    Digestion 63:214-9. 2001
    Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach.
  29. pmc Multiple active conformers of mouse ornithine decarboxylase
    S E Tsirka
    Department of Microbiology and Immunology, University of California San Francisco 94143
    Biochem J 293:289-95. 1993
    Purified recombinant mouse ornithine decarboxylase (ODC) was denatured with urea or with guanidinium chloride. Enzymic activity was efficiently recovered upon dilution of the denaturing agent...
  30. pmc Bulk segregant analysis followed by high-throughput sequencing reveals the Neurospora cell cycle gene, ndc-1, to be allelic with the gene for ornithine decarboxylase, spe-1
    Kyle R Pomraning
    Department of Biochemistry and Biophysics, 2011 ALS Bldg, Oregon State University, Corvallis, OR 97331 7305, USA
    Eukaryot Cell 10:724-33. 2011
    ..The single T-to-C point mutation maps to the gene encoding ornithine decarboxylase (ODC), spe-1 (NCU01271), and changes a Phe to a Ser residue within a highly conserved motif next to the ..
  31. ncbi Identification of the ornithine decarboxylase gene in the putrescine-producer Oenococcus oeni BIFI-83
    Angela Marcobal
    Depto de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    FEMS Microbiol Lett 239:213-20. 2004
    We report here the identification of an ornithine decarboxylase (ODC) gene in the putrescine-producer Oenococcus oeni BIFI-83 strain...
  32. pmc Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
    Jason A Zell
    Department of Epidemiology, University of California, Irvine, California 92697, USA
    Clin Cancer Res 15:6208-16. 2009
    Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer...
  33. doi Bursera fagaroides, effect of an ethanolic extract on ornithine decarboxylase (ODC) activity in vitro and on the growth of Entamoeba histolytica
    Paulina Rosas-Arreguín
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Universidad de Guanajuato, Apartado Postal No 187, Guanajuato, Gto 36000, Mexico
    Exp Parasitol 119:398-402. 2008
    The effect of an ethanolic extract from the stem bark of Bursera fagaroides on ornithine decarboxylase (ODC) activity in vitro and on the growth of Entamoeba histolytica was evaluated...
  34. pmc Studies on the regulation of ornithine decarboxylase in yeast: effect of deletion in the MEU1 gene
    Manas K Chattopadhyay
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 223, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:16158-63. 2005
    ..As the cell density increases, there is a marked fall in the level of ornithine decarboxylase (ODC) in the MEU1(+) cells, which we show is caused by an antizyme-requiring degradation system...
  35. ncbi Recurrent emergence of catalytically inactive ornithine decarboxylase homologous forms that likely have regulatory function
    Ivaylo P Ivanov
    Biosciences Institute, University College Cork, Ireland
    J Mol Evol 70:289-302. 2010
    b>Ornithine decarboxylase (ODC) catalyzes the first and rate limiting step in the biosynthesis of polyamines in most eukaryotes...
  36. pmc Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice
    Tamara Olenyik
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Mol Biochem Parasitol 176:109-11. 2011
    ..putrescine as a 1% solution in the drinking water ameliorated the profound loss of virulence exhibited by ornithine decarboxylase (ODC) deficient Leishmania donovani in mice...
  37. doi Staphylococcus pseudolugdunensis sp. nov., a pyrrolidonyl arylamidase/ornithine decarboxylase-positive bacterium isolated from blood cultures
    Yi Wei Tang
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Diagn Microbiol Infect Dis 60:351-9. 2008
    ..staphylococcal isolates recovered from blood cultures with positive pyrrolidonyl arylamidase and ornithine decarboxylase reactions were identified as Staphylococcus lugdunensis by the clinical microbiology laboratory...
  38. pmc Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase
    David C Smithson
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 285:16771-81. 2010
    ..The only validated molecular target for treatment of human African trypanosomiasis is ornithine decarboxylase (ODC), which catalyzes the first step in polyamine metabolism...
  39. ncbi Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2
    P C Hsu
    Department of Medicine, Da Chien General Hospital, Miao Li, Taiwan, ROC
    Apoptosis 11:389-99. 2006
    ..studies, prolactin induced Bcl-2 expression to prevent apoptosis and also provoked the activity of ornithine decarboxylase (ODC)...
  40. ncbi Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-acti
    Won Yoon Chung
    Department of Oral Biology, Yonsei University, College of Dentistry, Seodaemoon Gu, Seoul, Korea
    Carcinogenesis 28:1224-31. 2007
    ..underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling ..
  41. ncbi Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data
    Ori Cohavi
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Mol Biol 390:503-15. 2009
    ..It has the ability to bind and inhibit ornithine decarboxylase (ODC), targeting it for degradation. Az inhibitor (AzI) impairs the activity of Az...
  42. ncbi X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility
    Laurie K Jackson
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Boulevard, TX 75390 9041, USA
    J Biol Chem 278:22037-43. 2003
    b>Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the rate-determining step in the biosynthesis of polyamines. ODC is a proven drug target to treat African sleeping sickness...
  43. ncbi Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species
    G Y Liu
    Institute of Immunology, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China
    Apoptosis 10:569-81. 2005
    b>Ornithine decarboxylase (ODC) plays an essential role in various biological functions, including cell proliferation, differentiation and cell death. However, how it prevents the cell apoptotic mechanism is still unclear...
  44. pmc Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
    Robert J Rounbehler
    Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    Cancer Res 69:547-53. 2009
    ..A key downstream target of Myc oncoproteins in tumorigenesis is ornithine decarboxylase (Odc), the rate-limiting enzyme of polyamine biosynthesis...
  45. pmc Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses
    Anna C van Brummelen
    Department of Biochemistry, University of Pretoria, Pretoria, Gauteng 0002, South Africa
    J Biol Chem 284:4635-46. 2009
    ..an anti-malarial strategy, cytostasis caused by the co-inhibition of S-adenosylmethionine decarboxylase/ornithine decarboxylase in Plasmodium falciparum was studied with a comprehensive transcriptome, proteome, and metabolome ..
  46. ncbi Proteasomes begin ornithine decarboxylase digestion at the C terminus
    Mingsheng Zhang
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Biol Chem 279:20959-65. 2004
    ..We used the labile enzyme ornithine decarboxylase (ODC), which is recognized by the proteasome via a 37-residue C-terminal tag, to answer this question...
  47. ncbi Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin
    T G O'Brien
    The Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 57:2630-7. 1997
    In multistage tumorigenesis models, ornithine decarboxylase (ODC) is usually dysregulated at some point during tumor promotion, an early stage of carcinogenesis...
  48. ncbi Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase
    L Megosh
    Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 55:4205-9. 1995
    b>Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly inducible by growth-promoting stimuli in mouse epidermis but the enzyme level is only transiently elevated due to rapid turnover of the protein...
  49. ncbi Altering the reaction specificity of eukaryotic ornithine decarboxylase
    L K Jackson
    Department of Pharmacology and Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9041, USA
    Biochemistry 39:11247-57. 2000
    b>Ornithine decarboxylase (ODC) catalyzes the first committed step in the biosynthesis of polyamines, and it has been identified as a drug target for the treatment of African sleeping sickness, caused by Trypanosoma brucei...
  50. ncbi Arabidopsis polyamine biosynthesis: absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity
    C Hanfrey
    Division of Food Safety Science, Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK
    Plant J 27:551-60. 2001
    ..decarboxylation of ornithine could be detected in Arabidopsis extracts; however, we could not detect ornithine decarboxylase (ODC; EC 4. 1.1.17) enzymatic activity or any activity inhibitory to the ODC assay...
  51. ncbi Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases
    E Sandmeier
    Biochemisches Institut der Universitat Zurich, Switzerland
    Eur J Biochem 221:997-1002. 1994
    ....
  52. pmc Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs
    Michael Bekaert
    School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Bioinformatics 9:178. 2008
    b>Ornithine decarboxylase antizymes are proteins which negatively regulate cellular polyamine levels via their affects on polyamine synthesis and cellular uptake...
  53. pmc Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function
    Shira Albeck
    The Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 76100, Israel
    Protein Sci 17:793-802. 2008
    ..homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). AzI is highly homologous to ODC but is not enzymatically active...
  54. ncbi Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani
    Angana Mukherjee
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    J Antimicrob Chemother 59:204-11. 2007
    ..The present work investigates the mechanism of resistance to SAG in parasites isolated from patients who are unresponsive to SAG...
  55. ncbi The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase
    Baiqing Tang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochem Pharmacol 72:806-15. 2006
    ..MTOB treatment causes apoptosis and reduction of ornithine decarboxylase (ODC) activity but not ODC mRNA...
  56. ncbi Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
    O Heby
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Biochem Soc Trans 31:415-9. 2003
    Molecular, biochemical and genetic characterization of ornithine decarboxylase, S -adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of ..
  57. pmc The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
    Dirk Geerts
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 126:2012-24. 2010
    High polyamine (PA) levels and ornithine decarboxylase (ODC) overexpression are well-known phenomena in many aggressive cancer types...
  58. ncbi Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397
    Laurie K Jackson
    Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9041, USA
    Biochemistry 42:2933-40. 2003
    b>Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes the decarboxylation of l-Orn to putrescine, a rate-limiting step in the formation of polyamines...
  59. ncbi Structural elements of the ubiquitin-independent proteasome degron of ornithine decarboxylase
    Junko Takeuchi
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Biochem J 410:401-7. 2008
    Mouse ODC (ornithine decarboxylase) is quickly degraded by the 26S proteasome in mammalian and fungal cells...
  60. pmc Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme
    Anupam Jhingran
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    PLoS Negl Trop Dis 2:e115. 2008
    ..b>Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is a highly regulated ..
  61. pmc Regulation of all members of the antizyme family by antizyme inhibitor
    Ursula Mangold
    Center for Functional Genomics, Aventis Pharma GmbH, 82152 Martinsried, Germany
    Biochem J 385:21-8. 2005
    ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis. Polyamines are essential for cellular growth and differentiation but enhanced ODC activity is associated with cell transformation...
  62. pmc Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression
    J Nilsson
    Department of Cell and Molecular Biology, Division of Physiology, Umea University, S 901 87 Umea, Sweden
    Biochem J 346:699-704. 2000
    b>Ornithine decarboxylase (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine...
  63. ncbi Targeting polyamines of Aspergillus nidulans by siRNA specific to fungal ornithine decarboxylase gene
    Madhu Khatri
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    Med Mycol 45:211-20. 2007
    ..by RNAi strategy, we have examined the effect of siRNA specific to a key polyamine biosynthesis gene ornithine decarboxylase (ODC) on the in vitro germinating spores of A...
  64. ncbi Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells
    Pei Chen Hsu
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC
    Leuk Res 32:1530-40. 2008
    b>Ornithine decarboxylase (ODC), the rate-limiting enzyme of the polyamine biosynthetic pathway, plays an important role in cell cycle, tumor promotion and anti-apoptosis...
  65. ncbi Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter
    G L Law
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:19955-64. 1998
    Appropriate cellular levels of polyamines are required for cell growth and differentiation. Ornithine decarboxylase is a key regulatory enzyme in the biosynthesis of polyamines, and precise regulation of the expression of this enzyme is ..
  66. ncbi Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells
    L Turchanowa
    2nd Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany
    Eur J Clin Invest 31:887-93. 2001
    ..RESULTS: Indomethacin impaired growth of human colon cancer cells (Caco-2 and HCT-116). As a result, ornithine decarboxylase activity and c-myc protein expression were decreased...
  67. ncbi Mutants of Saccharomyces cerevisiae deficient in polyamine biosynthesis: studies on the regulation of ornithine decarboxylase
    C W Tabor
    Med Biol 59:272-8. 1981
    ..the following mutants in the polyamine biosynthetic pathway in yeast: (i) spe10 mutants, which have no ornithine decarboxylase activity and therefore cannot make putrescine; (ii) spe2 mutants, which have no adenosylmethionine ..
  68. ncbi A gene coding for ornithine decarboxylase (odcA) is differentially expressed during the Mucor circinelloides yeast-to-hypha transition
    José L Blasco
    Departamento de Microbiologia y Genetica, Universidad de Salamanca, Spain
    Res Microbiol 153:155-64. 2002
    ..Sequence analysis and database searches of this fragment revealed high similarity to ornithine decarboxylase (ODC) encoding genes. The odcA gene of M...
  69. doi Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, USA
    Biol Reprod 84:1139-47. 2011
    ....
  70. ncbi Single-injection ornithine decarboxylase-directed antisense therapy using atelocollagen to suppress human cancer growth
    Kunihiko Nakazawa
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer 109:993-1002. 2007
    Substantial evidence supports a direct role of ornithine decarboxylase (ODC) in the development and maintenance of human tumors...
  71. ncbi The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat
    Wee M Yeo
    Human Genome Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Microb Pathog 42:129-37. 2007
    ..e. ornithine decarboxylase (ODC1), gene trap ankyrin repeat (GTAR), and KIAA0697 expressed in brain tissue...
  72. ncbi Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio)
    Tomasz Hascilowicz
    Department of Biochemistry II, Jikei University School of Medicine, Minato, Tokyo 105 8461, Japan
    Biochim Biophys Acta 1578:21-8. 2002
    ..When cellular polyamine levels increase, antizyme, an ornithine decarboxylase (ODC) inhibitory protein, is induced by polyamine-dependent translational frameshifting...
  73. ncbi Putrescine activates oxidative stress dependent apoptotic death in ornithine decarboxylase overproducing mouse myeloma cells
    Omri Erez
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Exp Cell Res 281:148-56. 2002
    Accumulation of putrescine in ornithine decarboxylase overproducing cells provokes apoptotic death that is inhibited by 2-difluoromethylornithine, a specific inhibitor of ODC...
  74. ncbi Expression of arginine decarboxylase and ornithine decarboxylase genes in apple cells and stressed shoots
    Yu Jin Hao
    Department of Plant, Cell and Environment, National Institute of Fruit Tree Science, Tsukuba, Ibaraki 305 8605, Japan
    J Exp Bot 56:1105-15. 2005
    Arginine decarboxylase (ADC) and ornithine decarboxylase (ODC) are two important enzymes responsible for putrescine biosynthesis. In this study, a full-length ADC cDNA (MdADC) was isolated from apple [Malus sylvestris (L.) Mill. var...
  75. ncbi An endosymbiont positively modulates ornithine decarboxylase in host trypanosomatids
    Mariana Lins Frossard
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    Biochem Biophys Res Commun 343:443-9. 2006
    ..b>Ornithine decarboxylase (ODC) promotes polyamine biosynthesis and contributes to cell proliferation...
  76. ncbi Inhibition of polyamine biosynthesis in Acanthamoeba castellanii and 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by chitosanoligosaccharide
    Yun Hee Shon
    Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University, Kyongju 780 714, Korea
    Biotechnol Lett 25:701-4. 2003
    ..8 mM. Chitosanoligosaccharide strongly inhibited the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, which is enhanced in ..
  77. ncbi Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels
    Carmen M Bastida
    Department of Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Am J Physiol Endocrinol Metab 292:E1010-7. 2007
    ..marked sexual dimorphism affecting not only gland size and corticoid hormone secretion but also adrenal ornithine decarboxylase (ODC), polyamine, and catecholamine levels in which testosterone appears to be a major determinant...
  78. ncbi Induction of apoptotic cell death by putrescine
    Koichi Takao
    Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Int J Biochem Cell Biol 38:621-8. 2006
    The polyamines are essential for cellular growth and differentiation. Ornithine decarboxylase (ODC), which catalyses the first step in the biosynthesis of the polyamines, has a very fast turnover and is subject to a strong feedback ..
  79. ncbi Early carbonic anhydrase induction in the gills of the blue crab, Callinectes sapidus, during low salinity acclimation is independent of ornithine decarboxylase activity
    R P Henry
    Department of Biological Sciences, and the Alabama Agricultural Experiment Station, Auburn University, Auburn, Alabama 36849 5414 USA
    J Exp Zool 289:350-8. 2001
    ..Simultaneous measurements of ornithine decarboxylase (ODC) activity were made in gills and nonbranchial tissues to determine whether ODC activity and the ..
  80. ncbi Topoisomerase II is nonfunctional in polyamine-depleted cells
    K Alm
    Department of Animal Physiology, Lund University, Lund, Sweden
    J Cell Biochem 75:46-55. 1999
    ..Using the single cell gel electrophoresis assay, we also found that spermine depletion itself caused DNA strand breaks...
  81. ncbi The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus
    K Persson
    Department of Cellular and Developmental Biology, Umea University, S 901 87 Umea, Sweden
    Mamm Genome 10:784-8. 1999
    ..interspecific backcross, that Amd-2 is located on Chr 12, tightly linked to the gene (Odc) that encodes ornithine decarboxylase, another key enzyme in polyamine synthesis...
  82. ncbi Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans
    R R Mohan
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Cancer Res 5:143-7. 1999
    ..samples of pair-matched benign and cancer tissue obtained from the same PCA patient, we showed that ornithine decarboxylase (ODC) activity is significantly (P < 0...
  83. doi Ornithine decarboxylase G316A genotype and colorectal cancer risk
    D J Hughes
    Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide and Meath Hospital, Dublin, Ireland
    Colorectal Dis 13:860-4. 2011
    b>Ornithine decarboxylase (ODC) is a modifier of adenomatous polyposis coli-dependent tumourigenesis...
  84. pmc Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex
    Manas K Chattopadhyay
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bldg 8, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 406:177-82. 2011
    ..of synthesis by translational frameshifting and its ability to inhibit and facilitate the degradation of ornithine decarboxylase (ODC)...
  85. doi Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells
    Ya Fan Liao
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC
    Life Sci 82:367-75. 2008
    ..In our previous studies, ornithine decarboxylase (ODC) overexpression prevented tumor necrosis factor alpha (TNF-alpha)- and methotrexate-induced ..
  86. pmc Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity
    Ramesh M Ray
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:3674-90. 2012
    In a glucose-salt solution (Earle's balanced salt solution), asparagine (Asn) stimulates ornithine decarboxylase (ODC) activity in a dose-dependent manner, and the addition of epidermal growth factor (EGF) potentiates the effect of Asn...
  87. pmc Cross-talk between steroid-receptor-mediated and cell-membrane-receptor-mediated signalling pathways results in the in vivo modulation of c-Met and ornithine decarboxylase gene expression in mouse kidney
    M Dudkowska
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Biochem J 353:317-23. 2001
    ..Similarly, testosterone-induced ornithine decarboxylase (ODC) mRNA level and activity are decreased 2.8-7...
  88. doi The change of antizyme inhibitor expression and its possible role during mammalian cell cycle
    Yasuko Murakami
    Research Institute of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishi Tokyo, Tokyo 202 8585, Japan
    Exp Cell Res 315:2301-11. 2009
    ..These findings suggested that AIn contributed to a rapid increase in ODC at the G1 phase and also played a role in facilitating cells to complete mitosis during the cell cycle...
  89. ncbi The regulation of ornithine decarboxylase gene expression by sucrose and small upstream open reading frame in tomato (Lycopersicon esculentum Mill)
    S H Kwak
    Department of Biology, Yonsei University Shinchon-dong 134, Seodaemun-gu, Seoul, 120-749 Korea
    Plant Cell Physiol 42:314-23. 2001
    We identified a near-full-length cDNA clone encoding ornithine decarboxylase (ODC) from tomato (Lycopersicon esculentum Mill). It contained a small upstream open reading frame (uORF) within its 5' untranslated region...
  90. pmc RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis
    Yanjing Xiao
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Eukaryot Cell 8:747-55. 2009
    ..decarboxylase (AdoMetDC) led to the upregulation of the AdoMetDC activator, prozyme, and ornithine decarboxylase (ODC) proteins...
  91. ncbi Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
    T Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Cell Mol Life Sci 58:244-58. 2001
    ..Inhibitors of biosynthesis, polyamine analogues as well as oligonucleotide/polyamine analogue combinations are promising drug candidates for chemoprevention and/or treatment of cancer...
  92. ncbi Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc
    Merja Auvinen
    Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Int J Biochem Cell Biol 35:496-521. 2003
    ..This study indicates that the ornithine decarboxylase (ODC) gene is a physiological transcriptional target of c-Myc in association with induction of cell ..
  93. pmc Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions
    Lyn Marie Birkholtz
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    Biochem J 377:439-48. 2004
    ..falciparum AdoMetDC (S-adenosylmethionine decarboxylase)/ODC (ornithine decarboxylase)] with a molecular mass of 330 kDa...
  94. ncbi Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors?
    Aihua Deng
    Department of Medicine, University of California and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, CA 92161 9151, USA
    Diabetes 52:1235-9. 2003
    ..They can also contribute to hypertrophy. The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, increases in the early diabetic kidney to ..
  95. ncbi Polyamine levels of human colorectal adenocarcinomas are correlated with tumor stage and grade
    Thomas S Weiss
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Int J Colorectal Dis 17:381-7. 2002
    Cellular proliferation and differentiation are regulated by polyamines and their rate-limiting enzyme ornithine decarboxylase (ODC), both of which are correlated with tumor growth, but their role in differentiation is less clear...
  96. ncbi Genetic polymorphism in ornithine decarboxylase and risk of breast cancer
    Iain Brown
    School of Medicine and Dentistry, College of Life Sciences and Medicine, University of Aberdeen, Medical School, Foresterhill, Aberdeen AB25 2ZD, UK
    Fam Cancer 8:307-11. 2009
    b>Ornithine decarboxylase (ODC), the first enzyme in the biosynthesis of polyamines, has increased activity in breast cancer tissue compared with benign and normal tissues...
  97. pmc ATP-Dependent inactivation and sequestration of ornithine decarboxylase by the 26S proteasome are prerequisites for degradation
    Y Murakami
    Department of Biochemistry 2, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    Mol Cell Biol 19:7216-27. 1999
    ..b>Ornithine decarboxylase (ODC) is the only known enzyme to be degraded by the 26S proteasome without ubiquitinylation...
  98. pmc Bacillus anthracis endospores regulate ornithine decarboxylase and inducible nitric oxide synthase through ERK1/2 and p38 mitogen-activated protein kinases
    Supatra Porasuphatana
    Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand
    Curr Microbiol 61:567-73. 2010
    ..and the lethal toxin (LT) in mediating signaling pathways responsible for the induction of NOS2 and ornithine decarboxylase (ODC), which is the rate-limiting enzyme in the conversion of L-ornithine into polyamines...
  99. ncbi Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
    M K Smith
    Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    Carcinogenesis 19:1409-15. 1998
    b>Ornithine decarboxylase (ODC) is aberrantly regulated in tumor cells and results in high basal levels of ODC and polyamines in many epithelial tumors...
  100. pmc Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294 0019, USA
    Cancer Prev Res (Phila) 3:8-11. 2010
    ..DFMO is an inhibitor of ornithine decarboxylase, a key enzyme in the polyamine biosynthetic pathway. This perspective on Bailey et al...
  101. ncbi Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice
    Lei Young
    Blackburn Bld D06, Western Ave, University of Sydney, NSW 2006, Australia
    J Histochem Cytochem 54:223-9. 2006
    b>Ornithine decarboxylase (ODC) is the key enzyme in the polyamine synthesis pathway and is overexpressed in a variety of cancers...

Research Grants75

  1. STRUCTURE-FUNCTION OF PYRUVOYL & PLP-DEPENDENT ENZYMES
    MARVIN HACKERT; Fiscal Year: 1990
    ..of each cofactor type: a pyruvoyl- dependent histidine decarboxylase (Prv-HDC) and a PLP-dependent ornithine decarboxylase (PLP-ODC), both from Lactobacillus 30alpha, a Gram-positive bacterium resident in the mammalian gut...
  2. Angiotensin Adrenergic Interactions in the Kidney
    Roland Blantz; Fiscal Year: 2009
    ..kidney gluconeogenesis, 4) kidney cell proliferation due to growth stimuli using DFMO, inhibitor of ornithine decarboxylase, 5) NADPH oxidase and ROS, 6) decreased efficiency of Na reabsorption using micropuncture and ..
  3. DIET METHIONINE--S-ADO, POLYAMINES AND MAMMARY TUMORS
    ERVIN HAWRYLEWICZ; Fiscal Year: 1990
    ..Induction of ornithine decarboxylase (ODC) and increased polyamine synthesis (putrescine, spermidine and spermine) is associated with ..
  4. DIET METHIONINE--S-ADO, POLYAMINES AND MAMMARY TUMORS
    ERVIN HAWRYLEWICZ; Fiscal Year: 1992
    ..Induction of ornithine decarboxylase (ODC) and increased polyamine synthesis (putrescine, spermidine and spermine) is associated with ..
  5. Polyamine and trypanothione metabolism in Trypanosoma brucei
    Margaret A Phillips; Fiscal Year: 2010
    ..The polyamine biosynthetic enzymes, including ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are essential to the parasite and have been the ..
  6. Polyamine and trypanothione metabolism in Trypanosoma brucei
    Margaret Phillips; Fiscal Year: 2009
    ..The polyamine biosynthetic enzymes, including ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are essential to the parasite and have been the ..
  7. BIOSYNTHESIS OF COCAINE AND RELATED TROPANE ALKALOIDS
    EDWARD LEETE; Fiscal Year: 1991
    ..g. alpha-difluoromethyl ornithine which is an inhibitor or ornithine decarboxylase)...
  8. GENE AMPLIFICATION IN LEISHMANIA DONOVANI
    Buddy Ullman; Fiscal Year: 1992
    ..a difluoromethylornithine (DFMO)-resistant cell line that overproduces ornithine decarboxylase (ODC); ii...
  9. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2010
    ..Arginase generates L-ornithine, the substrate for the enzyme ornithine decarboxylase (ODC) that produces polyamines, which have been shown to enhance wound repair and have been implicated as ..
  10. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ..Arginase generates L-ornithine, the substrate for the enzyme ornithine decarboxylase (ODC) that produces polyamines, which have been shown to enhance wound repair and have been implicated as ..
  11. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2006
    ..The proposal will focus on arginase (ARG), agmatinase (AGM), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), and spermidine synthase (SYN), the entire ..
  12. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2004
    ..The proposal will focus on arginase (ARG), agmatinase (AGM), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), and spermidine synthase (SYN), the entire ..
  13. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2005
    ..The proposal will focus on arginase (ARG), agmatinase (AGM), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), and spermidine synthase (SYN), the entire ..
  14. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2002
    ..The proposal will focus on arginase (ARG), agmatinase (AGM), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), and spermidine synthase (SYN), the entire ..
  15. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2003
    ..The proposal will focus on arginase (ARG), agmatinase (AGM), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), and spermidine synthase (SYN), the entire ..
  16. TRYPANOSMIASIS--MOLECULAR APPROACHES TO CHEMOTHERAPY
    Margaret Phillips; Fiscal Year: 2000
    ..We have identified three drug targets, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and gamma-glutamylcysteine synthetase (gammaGCS), which ..
  17. TRYPANOSMIASIS--MOLECULAR APPROACHES TO CHEMOTHERAPY
    Margaret Phillips; Fiscal Year: 2001
    ..We have identified three drug targets, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and gamma-glutamylcysteine synthetase (gammaGCS), which ..
  18. TRYPANOSMIASIS--MOLECULAR APPROACHES TO CHEMOTHERAPY
    Margaret Phillips; Fiscal Year: 2002
    ..We have identified three drug targets, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and gamma-glutamylcysteine synthetase (gammaGCS), which ..
  19. TRYPANOSMIASIS--MOLECULAR APPROACHES TO CHEMOTHERAPY
    Margaret Phillips; Fiscal Year: 2003
    ..We have identified three drug targets, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and gamma-glutamylcysteine synthetase (gammaGCS), which ..
  20. TRYPANOSMIASIS--MOLECULAR APPROACHES TO CHEMOTHERAPY
    Margaret Phillips; Fiscal Year: 1999
    ..We have identified three drug targets, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and gamma-glutamylcysteine synthetase (gammaGCS), which ..
  21. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2006
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  22. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  23. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2007
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  24. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2007
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  25. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  26. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..polyamine inhibitors, DFMO and SAM486A, which specifically inhibit the polyamine biosynthetic enzymes ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), respectively...
  27. REGULATION OF GLYCOSOMAL BIOGENESIS IN T. BRUCEI
    C Wang; Fiscal Year: 1993
    ..This observation has ruled out any key role by ornithine decarboxylase (ODC) during the differentiation of T. brucei as originally anticipated...
  28. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2009
    ..The proposal will focus primarily on the L. donovani ornithine decarboxylase (LdODC) enzyme but will also impact upon other components of the polyamine pathway as well, including ..
  29. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2010
    ..The proposal will focus primarily on the L. donovani ornithine decarboxylase (LdODC) enzyme but will also impact upon other components of the polyamine pathway as well, including ..
  30. CNS NEUROPEPTIDES AND CELL DEVELOPMENT
    JORGE BARTOLOME; Fiscal Year: 1992
    ..beta-endorphin-(1-31) (BE; an opioid peptide naturally synthesized in the brain and pituitary), including ornithine decarboxylase activity (ODC; a growth-controlling enzyme), DNA synthesis (an index of cell replication), and insulin ..
  31. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA
    Buddy Ullman; Fiscal Year: 1993
    ..the purine phosphoribosyltransferases, the pterin-folate pathway, and the polyamine pathway and ornithine decarboxylase. An affinity labeling protocol will be developed further to identify the two leishmanial nucleoside ..
  32. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA
    Buddy Ullman; Fiscal Year: 1990
    ..the purine phosphoribosyltransferases, the pterin-folate pathway, and the polyamine pathway and ornithine decarboxylase. An affinity labeling protocol will be developed further to identify the two leishmanial nucleoside ..
  33. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA
    Buddy Ullman; Fiscal Year: 1991
    ..the purine phosphoribosyltransferases, the pterin-folate pathway, and the polyamine pathway and ornithine decarboxylase. An affinity labeling protocol will be developed further to identify the two leishmanial nucleoside ..
  34. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA
    Buddy Ullman; Fiscal Year: 1992
    ..the purine phosphoribosyltransferases, the pterin-folate pathway, and the polyamine pathway and ornithine decarboxylase. An affinity labeling protocol will be developed further to identify the two leishmanial nucleoside ..
  35. REGULATION OF ORNITHINE DECARBOXYLASE ACTIVITY
    John Mitchell; Fiscal Year: 1980
    ..essential to tissue growth and proliferation, is sensitively controlled by the activity of the enzyme, ornithine decarboxylase. The object of this study is to elucidate, in detail, the mechanism of regulation of ornithine ..
  36. Targeting S-adenosylmethionine decarboxylase for HAT drug discovery
    Margaret A Phillips; Fiscal Year: 2010
    ..The polyamine biosynthetic enzymes, including ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are essential to the parasite...
  37. MAMMALIAN POLYAMINE METABOLISM
    ANTHONY PEGG; Fiscal Year: 1999
    ..There is strong evidence that ornithine decarboxylase [ODC] and putrescine production may play a role in the action of carcinogens and tumor promoters and ..
  38. MAMMALIAN POLYAMINE METABOLISM
    ANTHONY PEGG; Fiscal Year: 2000
    ..There is strong evidence that ornithine decarboxylase [ODC] and putrescine production may play a role in the action of carcinogens and tumor promoters and ..
  39. NOVEL APPROACHES TO ANTIVIRAL CHEMOTHERAPY
    Krishna Agrawal; Fiscal Year: 1990
    ..new analogs would include: (a) ddN esters of alpha-difluoremethylornithine (DFMO) or other inhibitors of ornithine decarboxylase in an attempt to deplete polyamine levels to overcome bone marrow toxicity and increase anti-HIV activity;..
  40. Polyamine and glutathione metabolism in trypanosomes.
    Margaret Phillips; Fiscal Year: 2006
    ..The first committed step in the biosynthesis of polyamines is catalyzed by ornithine decarboxylase (ODC). This enzyme is one of the few validated targets for the treatment of parasitic diseases...
  41. Polyamine and glutathione metabolism in trypanosomes.
    Margaret Phillips; Fiscal Year: 2004
    ..The first committed step in the biosynthesis of polyamines is catalyzed by ornithine decarboxylase (ODC). This enzyme is one of the few validated targets for the treatment of parasitic diseases...
  42. FACSVantage SE Upgrade
    RAYMOND HESTER; Fiscal Year: 2004
    ..neuropathy, ataxia, retinitis pigmentosa) and MILS (maternally inherited Leigh Syndrome), 9) role of ornithine decarboxylase in the endothelial cell toxin, monocrotaline, 10) role of activated leukocyte cell adhesion molecule and ..
  43. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2005
    ..of polyamines, which occurs by activation of arginase that converts L-arginine to Lornithine, and of ornithine decarboxylase (ODC) that converts L-ornithine to the polyamines putrescine, spermidine, and spermine...
  44. ROLE OF POLYAMINES IN POSTNATAL COCHLEAR DEVELOPMENT
    Charles Henley; Fiscal Year: 1993
    ..The proposed research will test the hypothesis that the ornithine decarboxylase (ODC)-polyamine system plays a crucial role in cochlear development and that inhibition of the ODS-..
  45. ROLE OF POLYAMINES IN POSTNATAL COCHLEAR DEVELOPMENT
    Charles Henley; Fiscal Year: 1990
    ..The proposed research will test the hypothesis that the ornithine decarboxylase (ODC)-polyamine system plays a crucial role in cochlear development and that inhibition of the ODS-..
  46. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2009
    ..of polyamines, which occurs by activation of arginase that converts L-arginine to Lornithine, and of ornithine decarboxylase (ODC) that converts L-ornithine to the polyamines putrescine, spermidine, and spermine...
  47. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2007
    ..of polyamines, which occurs by activation of arginase that converts L-arginine to Lornithine, and of ornithine decarboxylase (ODC) that converts L-ornithine to the polyamines putrescine, spermidine, and spermine...
  48. H pylori Induced DNA Damage and Immune Dysregulation
    Keith Wilson; Fiscal Year: 2006
    ..of polyamines, which occurs by activation of arginase that converts L-arginine to Lornithine, and of ornithine decarboxylase (ODC) that converts L-ornithine to the polyamines putrescine, spermidine, and spermine...
  49. ORNITHINE DECARBOXYLASE AND ISCHEMIC BRAIN EDEMA
    Robert Dempsey; Fiscal Year: 1990
    ..for incomplete cerebral ischemia based on a better understanding of the pathophysiological role of ornithine decarboxylase in ischemic edema development...
  50. CANCER CHEMOPREVENTION BY SILYMARIN
    Rajesh Agarwal; Fiscal Year: 1999
    ..inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)- and other skin tumor promoter-induced epidermal ornithine decarboxylase (ODC) activity, and TPA-induced epidermal ODC mRNA expression...
  51. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2010
    ..Colon tumor cells produce high levels of polyamines endogenously through the activation of ornithine decarboxylase (ODC)...
  52. NUTRITIONAL MODIFICATION OF CANCER CELL GROWTH
    CRAIG BYUS; Fiscal Year: 1990
    ..Ornithine is decarboxylated by the enzyme ornithine decarboxylase to form putrescine, which in turn is converted to spermidine and spermine...
  53. Polyamine and glutathione metabolism in trypanosomes.
    Margaret Phillips; Fiscal Year: 2005
    ..The first committed step in the biosynthesis of polyamines is catalyzed by ornithine decarboxylase (ODC). This enzyme is one of the few validated targets for the treatment of parasitic diseases...
  54. Polyamine and glutathione metabolism in trypanosomes.
    Margaret Phillips; Fiscal Year: 2007
    ..The first committed step in the biosynthesis of polyamines is catalyzed by ornithine decarboxylase (ODC). This enzyme is one of the few validated targets for the treatment of parasitic diseases...
  55. MECHANISM OF ACTION OF CORTICOIDS IN THE SPINAL CORD
    Alejandro De Nicola; Fiscal Year: 1993
    ..We wish to establish if trauma induces the GC receptor. 2) Assay of enzymes, such as ornithine decarboxylase, glycerolphosphate dehydrogenase (GPDH), which are induced by GC in glial cells, as well as (Na,K)-ATPase,..
  56. MECHANISM OF ACTION OF CORTICOIDS IN THE SPINAL CORD
    Alejandro De Nicola; Fiscal Year: 1992
    ..We wish to establish if trauma induces the GC receptor. 2) Assay of enzymes, such as ornithine decarboxylase, glycerolphosphate dehydrogenase (GPDH), which are induced by GC in glial cells, as well as (Na,K)-ATPase,..
  57. POLYAMINES AND MONOCROTALINE PNEUMOTOXICITY (AHR-F1)
    JACK OLSON; Fiscal Year: 1999
    ..The proposed research addresses the applicant's working hypothesis that ornithine decarboxylase (ODC) regulation is a central convergence point for the multiple signaling pathways driving vascular ..
  58. H. Pylori Induced Oxidative Stress
    Keith Wilson; Fiscal Year: 2009
    ..Increased substrate for SMO is generated by synthesis of polyamines from L-ornithine by the enzyme ornithine decarboxylase (ODC)...
  59. TAS::75 0849::TAS
    Wenlin Deng; Fiscal Year: 2011
    ..that polyamine inhibition by a-difluoromethylornithine orDFMO, a selective and irreversible inhibitor of ornithine decarboxylase (ODC, the primary rate-limiting enzyme in the production of polyamines) significantly protects the ..