Genomes and Genes
Summary: A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Publications322 found, 100 shown here
- Structure and function of the plasminogen/plasmin systemFrancis J Castellino
W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
Thromb Haemost 93:647-54. 2005..system is dependent on the conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators urokinase-type Pg activator (uPA) or tissue-type plasminogen activator (tPA)...
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP ..
- The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombinT Osterwalder
Institute of Biochemistry, University of Zurich, Switzerland
J Biol Chem 273:2312-21. 1998..Although neuroserpin bound and inactivated plasminogen activators and plasmin, no interaction was observed with thrombin...
- Molecular mechanisms involved in the resistance of fibrin to clot lysis by plasmin in subjects with type 2 diabetes mellitusE J Dunn
Academic Unit of Molecular Vascular Medicine, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS1 3EX, UK
Diabetologia 49:1071-80. 2006....
- Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formationP Carmeliet
Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
Nat Genet 17:439-44. 1997..MMPs are secreted as inactive zymogens (pro-MMPs), requiring activation in the extracellular compartment. Plasmin, generated from the zymogen plasminogen by tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen ..
- The interaction of Streptococcus pneumoniae with plasmin mediates transmigration across endothelial and epithelial monolayers by intercellular junction cleavageCécile Attali
Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, Laboratoire d Ingénierie des Macromolécules, 41 rue Jules Horowitz, 38027 Grenoble, France
Infect Immun 76:5350-6. 2008..We observed that coating of S. pneumoniae R6 strain with plasminogen or inactivated plasmin increased adherence to pulmonary epithelial A549 and vascular endothelial EaHy cells in vitro...
- Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivoMonica Suelves
Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
Blood 99:2835-44. 2002b>Plasmin, the primary fibrinolytic enzyme, has a broad substrate spectrum and is implicated in biologic processes dependent upon proteolytic activity, such as tissue remodeling and cell migration...
- uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migrationC Legrand
Laboratoire Pol Bouin-CHU, , IFR 53, and, Reims, France
Exp Cell Res 264:326-36. 2001To examine the effects of the uPA/plasmin system on cell migration in relation to the activation of MMP-9, we used ex vivo and in vitro wound-repair models of human bronchial epithelial cells and videomicroscopy techniques that make ..
- Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniaeSimone Bergmann
Department of Microbial Pathogenicity, GBF German Research Centre for Biotechnology, 38124 Braunschweig, Germany
Mol Microbiol 49:411-23. 2003The interaction of Streptococcus pneumoniae with human plasmin(ogen) represents a mechanism to enhance bacterial virulence by capturing surface-associated proteolytic activity in the infected host...
- Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironmentsDavid J Mahoney
Medical Research Council Immunochemistry Unit, University of Oxford, United Kingdom
J Biol Chem 280:27044-55. 2005..We also show that heparin can modify another property of the Link module, i.e. its potentiation of the anti-plasmin activity of inter-alpha-inhibitor (IalphaI)...
- Analysis of the invasion-metastasis mechanism in pancreatic cancer: involvement of plasmin(ogen) cascade proteins in the invasion of pancreatic cancer cellsXiaodong Tan
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Int J Oncol 28:369-74. 2006To clarify the potential involvement of plasmin(ogen) cascade proteins in the cell dissociation and subsequent invasion of pancreatic cancer cells, western blot analysis, immunocytochemistry, immunohistochemistry, and in vitro invasion ..
- Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in miceJohn J Sheehan
Department of Pharmacological Sciences and Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794 8651, USA
J Neurosci 27:1738-45. 2007..Mice deficient in the serine protease plasmin exhibit decreased microglial migration to the site of excitatory neurotransmitter release and are resistant to ..
- Crystal structure of the catalytic domain of human plasmin complexed with streptokinaseX Wang
Crystallography Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
Science 281:1662-5. 1998..Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots...
- PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosisMasaya Yamaguchi
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
J Biol Chem 283:36272-9. 2008..motif in the whole-genome sequence of Streptococcus pneumoniae and identified one, which we called PfbA (plasmin- and fibronectin-binding protein A), that bound to human serum proteins...
- Mini-plasmin found in the epithelial cells of bronchioles triggers infection by broad-spectrum influenza A viruses and Sendai virusM Murakami
Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Japan
Eur J Biochem 268:2847-55. 2001..This protease was extracted from the membrane fraction of rat lungs, purified and then identified as a mini-plasmin. Mini-plasmin was distributed predominantly in the epithelial cells of the upward divisions of bronchioles and ..
- Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formationAlexandre Semov
Supratek Pharma Inc, Montreal, Quebec H9S 1A9, Canada
J Biol Chem 280:20833-41. 2005..A synthetic peptide corresponding to the N terminus of annexin II prevented S100A4-induced plasmin formation in the endothelial cell culture...
- The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasminK C Robbins
J Biol Chem 242:2333-42. 1967
- Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of lamininZ L Chen
Department of Pharmacology, University at Stony Brook, New York 11794 8651, USA
Cell 91:917-25. 1997..provoke neuronal death in the hippocampus, and the extracellular proteases tissue plasminogen activator (tPA) and plasmin (ogen) have been implicated in this death...
- RNA interference-mediated silencing of the S100A10 gene attenuates plasmin generation and invasiveness of Colo 222 colorectal cancer cellsLibo Zhang
Cancer Biology Research Group, Departments of Biochemistry and Molecular Biology and Oncology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 279:2053-62. 2004..of extracellular S100A10 protein and correlated with a 45% loss of plasminogen binding, a 65% loss in cellular plasmin generation and a complete loss in plasminogen-dependent cellular invasiveness...
- Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-DBradley K McColl
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
J Exp Med 198:863-8. 2003..Here, we report that the serine protease plasmin cleaved both propeptides from the VEGF homology domain of human VEGF-D and thereby generated a mature form ..
- The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathwaysLadislav Burysek
Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, D 89081 Ulm, Germany
J Biol Chem 277:33509-17. 2002The mechanism of proinflammatory activation of human monocytes by plasmin is unknown...
- Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1Guido Mannaioni
Dipartimento di Farmacologia, Universita degli Studi di Firenze, Firenze, Italy
J Biol Chem 283:20600-11. 2008Protease-activated receptor-1 (PAR1) is activated by a number of serine proteases, including plasmin. Both PAR1 and plasminogen, the precursor of plasmin, are expressed in the central nervous system...
- Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cellsAmbrose Y Jong
Division of Hematology Oncology, Mailstop 57, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
J Med Microbiol 52:615-22. 2003..albicans enolase to human plasminogen/plasmin was investigated. C...
- An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampusS E Tsirka
Department of Pharmacology, University Medical Center at Stony Brook, New York 11794 8651, USA
J Neurosci 17:543-52. 1997..Infusion of inhibitors of the extracellular tPA/plasmin proteolytic cascade into the hippocampus protects neurons against excitotoxic injury, suggesting a novel strategy ..
- The reaction between plasmin and C1-inhibitor results in plasmin inhibition by the serpin mechanismE W Brown
Department of Oral Medicine and Diagnostic Sciences, and Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
Blood Coagul Fibrinolysis 13:711-4. 2002..of plasma kallikrein and C1, but also has inhibitory activity against numerous other plasma proteinases such as plasmin. The relevance of plasmin inhibition by the C1-inhibitor has been debated, with some evidence showing that ..
- The hippocampal laminin matrix is dynamic and critical for neuronal survivalZu Lin Chen
Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York 10021, USA
Mol Biol Cell 14:2665-76. 2003..The disruption of the laminin layer by laminin-1 1) did not require the intact protein because infusion of plasmin-digested laminin-1 gave similar results; 2) was posttranscriptional, because there was no effect on laminin mRNA ..
- Plasma plasmin-alpha2-plasmin inhibitor complex levels are increased in systemic sclerosis patients with pulmonary hypertensionM Jinnin
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
Rheumatology (Oxford) 42:240-3. 2003To determine the frequency and clinical significance of plasma plasmin-alpha(2)-plasmin inhibitor complex (PIC) in patients with systemic sclerosis (SSc).
- Enhanced fibrin remodeling in vitro with TGF-beta1, insulin and plasmin for improved tissue-equivalentsM R Neidert
Department of Chemical Engineering and Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis 55455, USA
Biomaterials 23:3717-31. 2002..The optimal condition involved a combination of all three factors investigated-TGF-beta, insulin, plasmin-with medium replacement three times a week...
- Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4Todd M Quinton
Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Biol Chem 279:18434-9. 2004The activation of plasmin from its circulating precursor plasminogen is the mechanism of several clot-busting drugs used to clinically treat patients who have suffered a stroke; however, plasmin thus generated has been shown to activate ..
- Plasmin therapy enhances mobilization of HPCs after G-CSFMarc Tjwa
Vesalius Research Center, Leuven, Belgium
Blood 112:4048-50. 2008..Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF...
- A novel mechanism of plasmin-induced mitogenesis in fibroblastsS K Mandal
Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
J Thromb Haemost 3:163-9. 2005The plasminogen activator/plasmin system is believed to play an important role in diverse pathophysiological processes, including wound healing, vascular remodeling and pulmonary fibrosis...
- Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanismSara Monea
Department of Surgery, S A Localio Laboratory for General Surgery Research, New York, New York, USA
J Cell Physiol 192:160-70. 2002..We previously reported that plasmin treatment of cells results in proMMP-2 activation and increased type IV collagen degradation...
- Increased plasminogen binding is associated with metastatic breast cancer cells: differential expression of plasminogen binding proteinsM Ranson
Department of Biological Sciences, University of Wollongong, NSW Australia
Br J Cancer 77:1586-97. 1998..more cell-surface plasminogen in a lysine-dependent manner and (2) was capable of generating large amounts of plasmin compared with the non-metastatic cell lines MCF-7 and T-47D...
- Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasminTravis J MacLeod
Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 278:25577-84. 2003..AIIt or its annexin A2 subunit and the ligands, tissue-type plasminogen activator (t-PA), plasminogen, and plasmin. AIIt bound t-PA (Kd = 0.68 microm), plasminogen (Kd = 0...
- Plasmin generation dependent on alpha-enolase-type plasminogen receptor is required for myogenesisRoser Lopez-Alemany
Institut de Recerca Oncològia, Centre d Oncologia Molecular, L Hospitalet de Llobregat, Barcelona, Spain
Thromb Haemost 90:724-33. 2003b>Plasmin is a potent extracellular protease specialized in the degradation of fibrin (fibrinolysis)...
- Plasmin/plasminogen system in colorectal cancerDavid H Berger
Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
World J Surg 26:767-71. 2002..One of the main protease systems involved in tumor cell invasion and metastasis is the plasminogen/plasmin system (PPS)...
- TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivoH G Wisniewski
Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, NY 10016, USA
J Immunol 156:1609-15. 1996..In this work, we show that TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. The plasmin/plasminogen activator system is important in the protease network associated with inflammation...
- TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1Cynthia E Wilkins-Port
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
Cancer Res 69:4081-91. 2009..significant increase in matrix metalloproteinase (MMP)-10 expression and involved a proteolytic axis composed of plasmin, MMP-10, and MMP-1. Neutralization of any one component in this cascade inhibited collagen gel lysis...
- Autologous plasmin for pharmacologic vitreolysis prepared 1 hour before surgeryStanislao Rizzo
Eye Surgery Clinic, Department of Immunohaematology and Transfusion Medicine, Santa Chiara Hospital, Pisa, Italy
Retina 26:792-6. 2006To evaluate the safety and efficacy of intravitreal injection of autologous plasmin enzyme (APE) in inducing a posterior vitreous detachment (PVD). APE was obtained by a modified method 1 hour before surgery.
- Novel aspects and new roles for the serine protease plasminT Syrovets
Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstr 20, 89081 Ulm, Germany
Cell Mol Life Sci 61:873-85. 2004The serine protease plasmin is distributed throughout the human body in the form of the zymogen plasminogen...
- Plasmin triggers cytokine induction in human monocyte-derived macrophagesQun Li
Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstr 20, D 89081 Ulm, Germany
Arterioscler Thromb Vasc Biol 27:1383-9. 2007Fibrinolytic activity is upregulated in atherosclerotic lesions, yet little is known about the role of plasmin in macrophage function. We postulated a direct effect of plasmin on human monocyte-derived macrophages.
- Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids. Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulationAnna Tanka-Salamon
Department of Medical Biochemistry, Semmelweis University, Puskin u 9, Budapest, Hungary
FEBS J 275:1274-82. 2008Thrombi, which are dissolved primarily by plasmin (EC 188.8.131.52.), contain up to millimolar concentrations of fatty acids and these are known to affect the action of the protease...
- Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulpNaoto Kamio
Department of Endodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271 8587, Japan
Biochem Pharmacol 75:1974-80. 2008b>Plasmin is a proteolytic enzyme produced from plasminogen by plasminogen activators. We investigated the function of plasmin in human dental pulp fibroblast-like cells...
- Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epitheliaTod A Brown
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Biol Chem 279:14772-83. 2004..Identity was confirmed by digestion and phosphorylation studies with recombinant gp140-GFP. Plasmin, a serum protease, also converts gp140 to p80, providing biological significance to the cleavage in wounds...
- Acute tissue damage after injections of thrombin and plasmin into rat striatumM Xue
Department of Pathology, Manitoba Institute of Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Stroke 32:2164-9. 2001..5 U/5 microL) plasminogen, and low- (0.335 U/5 microL) and high-dose (3.35 U/5 microL) plasmin. Forty-eight hours later rats were perfusion fixed...
- Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytesYves Laumonnier
Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstrasse 20, D 89081 Ulm, Germany
Blood 107:3342-9. 2006We have previously demonstrated that plasmin acts as a potent proinflammatory activator of human peripheral monocytes...
- Posterior vitreous detachment with plasmin in the isolated human eyeXiaoxin Li
Department of Ophthalmology, People s Hospital, Peking University, Beijing, PRC
Graefes Arch Clin Exp Ophthalmol 240:56-62. 2002To investigate the efficacy and safety of intravitreal injection of plasmin in producing posterior vitreous detachment (PVD), and the possible role of plasmin in degrading adhesion glycoproteins of the internal limiting membrane (ILM).
- Use of autologous plasmin during vitrectomy for diabetic maculopathyT Sakuma
Department of Ophthalmology, Juntendo University, Urayasu Hospital, Urayasu, Chiba, Japan
Eur J Ophthalmol 16:138-40. 2006To evaluate the efficacy of autologous plasmin enzyme as an adjunct to vitrectomy in diabetic macular edema.
- Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatinTakehiko Tarui
Department of Cell Biology, VB 6, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Biol Chem 277:33564-70. 2002..b>Plasmin, the parent molecule of angiostatin and a major extracellular protease, induces platelet aggregation, migration ..
- Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrugFranciscus M H de Groot
Department of Organic Chemistry, NSR Center for Molecular Structure, Design and Synthesis, University of Nijmegen, 6525 ED Nijmegen, The Netherlands
Mol Cancer Ther 1:901-11. 2002..sequence is a D-Ala-Phe-Lys tripeptide that is selectively recognized by the tumor-associated protease plasmin, which is involved in tumor invasion and metastasis...
- Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generationA T Jacovina
Division of Hematology-Oncology, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 276:49350-8. 2001..A growing body of evidence suggests that this process may be dependent upon plasmin, a serine protease generated from plasminogen (Plg) by either urokinase Plg activator (u-PA) or tissue Plg ..
- Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathwayLirlandia P Sousa
Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
Biochem Biophys Res Commun 337:1065-71. 2005Previously we have demonstrated that both plasminogen (Plg) and plasmin (Pla) regulate the expression of the transcription factors c-FOS and EGR-1 [L.P. De Sousa, B.S. Brasil, B.M. Silva, M.H. Freitas, S.V. Nogueira, P.C. Ferreira, E.G...
- Regulation of plasminogen binding to neutrophilsT Herren
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, OH, USA
Blood 97:1070-8. 2001..In support of this hypothesis, treatment of neutrophils with elastase, cathepsin G, or plasmin increased their plasminogen binding, and specific inhibitors of elastase and cathepsin G suppressed the up-..
- Plasmin enzyme-assisted vitreoretinal surgery in congenital X-linked retinoschisis: surgical techniques based on a new classification systemWei Chi Wu
Associated Retinal Consultants, PC, Royal Oak, Michigan 48073, USA
Retina 27:1079-85. 2007To review the surgical outcome of autologous plasmin enzyme-assisted vitreoretinal surgery in managing complications associated with congenital X-linked retinoschisis (CXLRS).
- Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood lossSimone M Flight
School of Medicine, University of Queensland, Brisbane, Australia
Br J Haematol 145:207-11. 2009..inhibitor from Pseudonaja textilis venom with sequence relatedness to aprotinin, is a potent but reversible plasmin inhibitor and has a narrower range of protease inhibition compared to aprotinin...
- Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1Naamit Deshet
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
J Cell Physiol 216:632-9. 2008..We studied the effect of plasminogen (PGN), an inactive precursor of the PAR-1-activating protease, plasmin (PN) on aggregation of pancreatic adenocarcinoma (PDAC) cells...
- Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin systemC Ferland
, Centre de Recherche, , , Laval, Quebec, Canada
J Leukoc Biol 69:772-8. 2001..4%, whereas inhibition of the plasminogen-plasmin system decreased eotaxin's effect by < or = 44.4% (P = 0.0002)...
- Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiencyA Ny
Department of Medical Biochemistry and Biophysics, Umea University, Sweden
Eur J Biochem 244:487-93. 1997..we have studied the regulation of plasmin activity in the ovaries of 25-day-old wild-type mice and mice with deficient PA gene function during gonadotropin-..
- Acquisition of host plasmin activity by the Swine pathogen Streptococcus suis serotype 2Marie Claude Jobin
Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada
Infect Immun 72:606-10. 2004..One of the receptors was identified as glyceraldehyde-3-phosphate dehydrogenase. S. suis-associated plasmin activity was capable of activating free plasminogen, which in turn could contribute to degradation of fibronectin...
- Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator-plasmin cascadeDuc M Le
Department of Oncology, University of Calgary, Calgary, Alberta, Canada
J Neurosci 23:4034-43. 2003..coculture was investigated and was found to involve the urokinase-type plasminogen activator (uPA)-plasmin cascade whereby uPA bound to uPA receptor (uPAR), leading to the conversion of plasminogen to plasmin...
- Activated thrombin-activatable fibrinolysis inhibitor reduces the ability of high molecular weight fibrin degradation products to protect plasmin from antiplasminMark Schneider
Departments of Biochemistry and Medicine, Queen s University, Kingston Ontario K7L 3N6, Canada
J Biol Chem 279:13340-5. 2004..B-like plasma enzyme that can slow clot lysis by removing lysine residues exposed on fibrin as it is cleaved by plasmin. Previously, it was shown that fibrin treated with TAFIa is less able to promote plasminogen activation by tissue-..
- A mediator of cell surface-specific plasmin generationC Brownstein
Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA
Ann N Y Acad Sci 947:143-55; discussion 155-6. 2001It has become increasingly evident that the generation of cell surface proteases including plasmin is fundamental to a wide variety of in vivo biological processes...
- Inhibitory role of eosinophils on cell surface plasmin generation by bronchial epithelial cells: inhibitory effects of transforming growth factor betaK Hara
Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
Lung 179:9-20. 2001..We studied the effect of eosinophils on cell surface plasmin generation by bronchial epithelial cells, because plasmin is thought to be involved in bronchial tissue repair/..
- The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivoArames Crameri
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
EMBO J 25:432-43. 2006..This was associated with inefficient plasminogen binding and plasmin activation, the displacement of beta-secretase (BACE) from DRMs to APP-containing membrane fractions, increased ..
- Nonclinical safety and pharmacokinetics of intravitreally administered human-derived plasmin in rabbits and minipigsJoel W Proksch
Global Preclinical Development, Bausch and Lomb, Rochester, NY 14609, USA
J Ocul Pharmacol Ther 24:320-32. 2008The use of plasmin for pharmacologic vitreolysis and the creation of a posterior vitreous detachment offers several potential advantages over surgery...
- Plasmin/plasminogen is essential for the healing of tympanic membrane perforationsJinan Li
Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
Thromb Haemost 96:512-9. 2006..and re-epithelialization were completely arrested in plasminogen-deficient mice indicates that plasminogen/plasmin plays a more profound role in the healing of tympanic membrane perforations than in the healing of other ..
- Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cellsYingchun Hou
Department of Cell Biology, School of Life Sciences, Shaanxi Normal University, Xi an, Shaanxi, China
Cancer Invest 26:809-15. 2008Annexin A2 (ANXA2) was reported as the receptor, activator, expression enhancer, or cooperator for plasmin, S100A10, and others...
- Effects of metal ions on activity of plasminPawel Nowak
Department of General Biochemistry, University of Lodz, Lodz, Poland
Biol Trace Elem Res 93:87-94. 2003The effects of some metal ions on amidolytic and fibrinogenolytic activities of highly purified human plasmin were investigated in vitro...
- Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in miceP Carmeliet
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
J Cell Biol 140:233-45. 1998..Pericellular plasmin proteolysis, evaluated by degradation of 125I-labeled fibrin and activation of zymogen matrix metalloproteinases, ..
- Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibitionMichael O Griffin
Department of Medicine, University of California, San Diego, CA 2103 8412, USA
Mol Cell Biochem 270:1-11. 2005..We hypothesized that activation of MMPs and the serine protease plasmin contribute to early cardiac myocyte death following I/R and that broad-spectrum protease inhibition with ..
- p11 regulates extracellular plasmin production and invasiveness of HT1080 fibrosarcoma cellsKyu Sil Choi
Cancer Biology Research Group, Department of Medical Science, University of Calgary Calgary, Alberta, Canada T2N4N1
FASEB J 17:235-46. 2003..Most cancer cells secrete the urokinase-type plasminogen activator, which converts cell-bound plasminogen to plasmin. Here we address the issue of whether the plasminogen binding protein, p11, plays a significant role in this ..
- Cellular mechanisms regulating non-haemostatic plasmin generationR Bass
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U K
Biochem Soc Trans 30:189-94. 2002..A central mechanism for regulating plasmin generation is through the binding of the two plasminogen activators to specific cellular receptors: urokinase-..
- Thrombolytic potency of acid-stabilized plasmin: superiority over tissue-type plasminogen activator in an in vitro model of catheter-assisted thrombolysisV Novokhatny
Bayer Corporation, Biological Products Division, Research Triangle Park, North Carolina 27709, USA
J Thromb Haemost 1:1034-41. 2003b>Plasmin, the direct fibrinolytic enzyme, was compared with tissue plasminogen activator (t-PA) in an in vitro thrombolysis model...
- Plasminogen activation/plasmin in rheumatoid arthritis: matrix degradation and moreMartin O Judex
Sidney Kimmel Cancer Center, San Diego, California, USA
Am J Pathol 166:645-7. 2005..1,2) Through the use of an experimental mouse model of RA, Li and colleagues(6) have implicated plasmin as an essential component of the early phase of RA, as reported in this issue of The American Journal of Pathology...
- High-molecular-mass and low-molecular-mass kininogens block plasmin-induced platelet aggregation by forming a complex with kringle 5 of plasminogen/plasminT E Selim
Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
Eur J Biochem 250:532-8. 1997..67 microM) or LK (3 microM) with Plg (1.5 microM) did not affect its conversion to plasmin by tissue plasminogen activator (t-PA) (10 U/ml) in the presence of a tissue plasminogen stimulator (0.14 microM)...
- Identification of amino acids in antiplasmin involved in its noncovalent 'lysine-binding-site'-dependent interaction with plasminHaiyao Wang
Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
Eur J Biochem 270:2023-9. 2003The lysine-binding-site-mediated interaction between plasmin and antiplasmin is of great importance for the fast rate of this reaction. It also plays an important part in regulating the fibrinolytic enzyme system...
- Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasminRonald R Bean
Department of Pathology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 280:7504-10. 2005The role of the streptokinase (SK) alpha-domain in plasminogen (Pg) and plasmin (Pm) interactions was investigated in quantitative binding studies employing active site fluorescein-labeled [Glu]Pg, [Lys]Pg, and [Lys]Pm, and the SK ..
- Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injuryJ A Indyk
Department of Pharmacology, University at Stony Brook, Stony Brook, NY 11794 8651, USA
Neuroscience 116:359-71. 2003..The tissue plasminogen activator/plasmin extracellular protease cascade and downstream laminin degradation are implicated in excitotoxin-induced neuronal ..
- Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritisYongzhi Guo
Umea University, Umea, Sweden
Arthritis Rheum 58:764-72. 2008To assess the functional roles of plasmin in a murine model of Staphylococcus aureus-induced bacterial arthritis.
- Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brainJeremy Pak Hong Chow
Division of Molecular Neurobiology, National Institute for Basic Biology, 5 1 Higashiyama, Myodaiji cho, Okazaki, Aichi 444 8787, Japan
Neurosci Lett 442:208-12. 2008..Here, we identified the proteolytic processing of Ptprz by plasmin in the mouse brain, which is markedly enhanced after kainic acid (KA)-induced seizures...
- A comparison of cyclohexanone and tetrahydro-4H-thiopyran-4-one 1,1-dioxide as pharmacophores for the design of peptide-based inhibitors of the serine protease plasminFengtian Xue
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
J Org Chem 70:8309-21. 2005..The serine protease plasmin has a central role in the plasminogen system...
- Evoking plasmin for beta-amyloid clearanceJian Zhao
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell Res 18:803-4. 2008
- On the mechanism of the reaction between human alpha 2-antiplasmin and plasminB Wiman
J Biol Chem 254:9291-7. 1979
- Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cellsNathalie Beaufort
Unité de Défense Innée et Inflammation Inserm E336, Département de Médecine Moléculaire, Institut Pasteur, 25 28 Rue du Docteur Roux, F 75724 Paris Cedex 15, France
FEBS Lett 574:89-94. 2004..soluble CD87 and to CD87-expressing epithelial cells, we establish that exogenous or in situ generated plasmin proteolyzes CD87 in the D1-D2 linker and D3 carboxyterminal sequences, producing a major soluble D2D3 species...
- The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptorsHongjie Yuan
Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
J Biol Chem 284:12862-73. 2009..The serine protease plasmin can cleave a number of substrates, including protease-activated receptors, and may play an important role in ..
- [Enzymatic vitrectomy by intravitreal autologous plasmin injection, as initial treatment for diffuse diabetic macular edema]M Diaz-Llopis
Departamento de Oftalmologia, Hospital Geneneral Universitario, Unidad Docente de Oftalmología, Facultad de Medicina, Universidad de Valencia, Valencia, Espana
Arch Soc Esp Oftalmol 83:77-84. 2008To determine whether intravitreal injection of plasmin is effective in treating diffuse diabetic macular edema (DDME).
- Association studies between the plasmin genes and late-onset Alzheimer's diseaseNobuto Shibata
Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
Neurobiol Aging 28:1041-3. 2007The plasmin system is involved in the degradation of Abeta peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD)...
- A proteinase inhibitor from Caesalpinia echinata (pau-brasil) seeds for plasma kallikrein, plasmin and factor XIIaIlana Cruz-Silva
Departamento de Bioquimica, Universidade Federal de Sao Paulo, 04044 020 Sao Paulo, SP, Brazil
Biol Chem 385:1083-6. 2004..CeKI inhibits human plasma kallikrein ( K i =3.1 nM), plasmin ( K i =0.18 nM), factor XIIa ( K i =0.18 nM), trypsin ( K i =21.5 nM) and factor Xa ( K i =0.49 mM)...
- Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasminJennifer A Hunt
Talecris Biotherapeutics, 85 TW Alexander Dr, Research Triangle Park, NC 27709, USA
Thromb Haemost 100:413-9. 2008..mutant Delta(K2-K5)Pm by plasminogen activators was evaluated, and functional characteristics of the simplified plasmin were studied. Properties of Delta(K2-K5)Pg were similar to native, human plasma-derived plasminogen...
- Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesisS Brodsky
Department of Medicine, State University of New York, Stony Brook, New York 11794 8152, USA
Am J Physiol Heart Circ Physiol 281:H1784-92. 2001..gain insight into the requirement for different matrix-degrading systems during endothelial cell migration across plasmin-degradable basement membranes compared with profibrotic areas containing plasmin-nondegradable collagen, we ..
- Effect of external ocular surgery and mode of post-operative care on plasminogen, plasmin, angiostatins and alpha(2)-macroglobulin in tearsM Lembach
SUNY College of Optometry, 33 West 42nd Street, New York, NY 10036, USA
Curr Eye Res 22:286-94. 2001..whether corneal surgery and the mode of post-surgical treatment influence the distribution of plasminogen, plasmin, angiostatins and alpha(2)-macrogobulin in tear fluid. METHODS...
- The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretionQijiao Jiang
Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92161, USA
Ann N Y Acad Sci 971:445-9. 2002Chromaffin cells express components of the plasminogen/plasmin system, including its major activator, tissue plasminogen activator (t-PA), and high-affinity cellular receptors for plasminogen, which promote local concentration and ..
- Plasmin in renal interstitial fibrosis: innocent or guilty?Guoping Zheng
Kidney Int 66:455-6. 2004
- Cloning, sequencing and functional overexpression of the Streptococcus equisimilis H46A gapC gene encoding a glyceraldehyde-3-phosphate dehydrogenase that also functions as a plasmin(ogen)-binding protein. Purification and biochemical characterization of K Gase
Institute for Molecular Biology, Jena University, Germany
Eur J Biochem 239:42-51. 1996..prerequisite to understanding possible mechanisms that control the balance between the plasminogen activating and plasmin(ogen) binding capacities of H46A, we describe here its gapC gene encoding glyceraldehyde-3-phosphate ..
- Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activationT Syrovets
Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstrasse 20, D-89081 Ulm, Germany
Blood 97:3941-50. 2001It was previously shown that plasmin activates human peripheral monocytes in terms of lipid mediator release and chemotactic migration...
- Regulation of plasmin-induced protease-activated receptor 4 activation in plateletsYingying Mao
Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
Platelets 20:191-8. 2009b>Plasmin, a major extracellular protease, activates platelets through PAR4 receptors. Plasmin-induced full aggregation is achieved at lower concentrations (0.1 U/mL) in murine platelets as compared to human platelets (1 U/mL)...
- Pediatric traumatic macular hole: results of autologous plasmin enzyme-assisted vitrectomyWei Chi Wu
Associated Retinal Consultants, PC, Royal Oak, Michigan 48073, USA
Am J Ophthalmol 144:668-672. 2007To review our experience with plasmin-assisted vitrectomy surgery for the treatment of pediatric macular holes.
- Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasminYahong Zhang
Immunopathology Section, National Institute of Dental and Craniofacial Research NIH, Bethesda, MD 20892, USA
J Immunol 179:3297-304. 2007..Urokinase-type plasminogen activator (uPA) and plasmin, in addition to their role in fibrinolysis and activation of pro-MMPs, have been shown to transduce intracellular ..
- Pericellular plasmin induces smooth muscle cell anoikisOlivier Meilhac
INSERM U460, CHU Bichat Claude Bernard, 75018 Paris, France
FASEB J 17:1301-3. 2003..Using primary cultures of arterial SMCs, we show that plasmin generated from plasminogen on the cell surface induces cell retraction and fibronectin fragmentation, leading to ..
- Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemiaHiroshi Takahashi
Department of Neurosurgery, Fujinomiya City General Hospital, Fujinomiya shi, Shizuoka ken 418 0076, Japan
Neurosci Lett 381:189-93. 2005We studied the possible involvement of the tissue plasminogen activator (t-PA)/plasmin system on both delayed neuronal death in the hippocampus and the associated enhancement of locomotor activity in rats, after transient forebrain ..
- A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivoWilliam P Sheffield
McMaster University, Department of Pathology and Molecular Medicine, HSC 4N66, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
Thromb Haemost 101:867-77. 2009..reconfiguration of the chimera, appending human serum albumin (HSA) to the N-terminus of HV3, with an intervening plasmin cleavage site, would create a slowly cleared, plasmin-activatable HV3...
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..These serpins target protease cascades in the clot dissolving thrombolytic (uPA, tPA for Serp-1 and NSP;plasmin for Serp-1 ) and clot forming thrombotic pathways (fXa for Serp-1)...
- Cross-talk Between Coagulation, Inflammation, and ImmunityLawrence L Leung; Fiscal Year: 2013..plays a broad anti-inflammatory role in vivo;the targets for CPB include bradykinin, C5a, the generation of plasmin and thrombin-cleaved osteopontin (OPN-Arg or OPN-R)...
- Clinical Development of Hemostatic Agent ClotFoam for Severe HemorrhageMaja Nowakowski; Fiscal Year: 2013..ClotFoam(R) is also a plasmin-depleted aprotinin-and-thrombin-free fibrin sealant presenting no risk of autoimmune reaction to blood products...
- Dual Direct Inhibitors of Thrombin and Factor XaUMESH RAMANLAL DESAI; Fiscal Year: 2012..with proteins (factors IIa, Xa, XIa, XIIa, XIIIa, IXa, VIIa, antithrombin, kallikrein, activated protein C plasmin, trypsin, etc...
- The Role of Carboxypeptidase B and its Substrates in Rheumatoid ArthritisWilliam H Robinson; Fiscal Year: 2013..an anti-fibrinolytic role by removing C-terminal lysine residues from fibrin, thereby preventing its cleavage by plasmin. Recently, C3a, C5a, thrombin-cleaved osteopontin (OPN-R) and bradykinin were identified as additional substrates ..
- Regulation of Leukocyte Migration by PlasminogenJANE LEE HOOVER-PLOW; Fiscal Year: 2013..mice in peritonitis and abdominal aortic aneurysm (AAA) models, our studies provide in vivo evidence that Plg/plasmin is required for macrophage recruitment and this role is mediated through activation of MMP-9...
- Cell Surface Plasminogen Activation and HypertensionRobert J Parmer; Fiscal Year: 2013..role for serine protease-mediated cleavage of ENaC subunits in ENaC activation, and recent studies suggest that plasmin is a key protease in this process...
- Cthrc1 function as a novel TGF-beta antagonist in the vasculatureVolkhard Lindner; Fiscal Year: 2013..the TGF-ss signaling pathway, and iii) to determine the function of the identified Cthrc1 fragments generated by plasmin. This proposal will employ mouse models of Cthrc1 gain-of-function and loss-of function, in combination with ..
- PLASMINOGEN AND PLASMIN: STRUCTURE AND FUNCTIONFrancis J Castellino; Fiscal Year: 2013..Through this overal mechanism, M and M-like proteins enhance the activation of Pg to the serine protease, plasmin (Pm), by bacterial or host Pg activators, thus creating a proteolytic bacterial microenvironment employed by GAS ..
- Plasminogen activator inhibitor-1 in tumor progression and metastasisYves A DeClerck; Fiscal Year: 2013..of the family of endogenous serine protease inhibitors (serpins) that controls the activation of plasminogen into plasmin by tissue and urokinase type plasminogen activators (tPA and uPA, respectively)...
- MATRIX MEDIATORS OF WOUND HEALINGPaul J Higgins; Fiscal Year: 2010Plasminogen activator inhibitor type-1 (PAI-1) is the major physiologic regulator of the plasmin-based pericellular proteolytic cascade and a critical element in pathologic angiogenesis in vivo. PAI-1 controls stromal proteolysis (i.e...
- Neonatal Anesthetic NeurotoxicityPiyush M Patel; Fiscal Year: 2013..from synaptic vesicles as a pro molecule (proBDNF) and undergoes proteolytic cleavage in the synaptic cleft by plasmin to generate mature BDNF (mBDNF) ...
- Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for StrokeIrina Y Sazonova; Fiscal Year: 2012..for development of new therapeutic agents for stroke, submits this Innovative Research Proposal entitled "Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke"...
- The role of the terminal complement pathway in experimental cerebral malaria.Theresa N Ramos; Fiscal Year: 2012..What is the relative importance of extrinsic protease activation pathway (via proteases such as thrombin and plasmin) to C5- mediated inflammation in ECM? Based on our preliminary observations, we hypothesize that C5 is the ..
- Modulation of the Epithelial Sodium Channel by Proteases and Peptide InhibitorsCHRISTOPHER JOHN PASSERO; Fiscal Year: 2010..Other serine proteases besides furin and prostasin can activate these channels. Recent evidence suggests plasmin and matrix metalloproteinases activate ENaC...
- Mesenchymal Cell Fate Determination by Extracellular Matrix StiffnessJeffrey C Horowitz; Fiscal Year: 2013..Moreover, plasmin-mediated ECM proteolysis, which induces myofibroblast apoptosis, is associated with the loss of FAK activity...
- Role of the Plasminogen Activator Protease during Pneumonic PlagueWyndham W Lathem; Fiscal Year: 2013..In vitro, Pla converts host plasminogen to the active plasmin form...
- Novel Methods for Dissolving Blood ClotsGUY LELAND REED; Fiscal Year: 2013..discovered a molecule that dissolves blood clots through a unique mechanism-inactivating the major inhibitor of plasmin. Through synergism, this molecule increases the potency and specificity of TPA, and it avoids TPA-related ..
- PAR-1 Signaling and HANDKATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013..Levels of PAR-1 activators, including plasmin and matrix metalloproteinases (MMPs), are substantially increased in HIV associated neurological disorders (HAND) ..
- Preclinical Development of a Novel Plaque-Regressing Therapy For AtherosclerosisMichael W Fanger; Fiscal Year: 2012..model of atherosclerosis, that rPAI-123 stimulates plaque regression in a dose-dependent manner through the novel plasmin regulatory pathway, thereby identifying the optimal rPAI-123 dosing for future pre-clinical studies;and 2) to ..
- Hyperamylinemia in Diabetic Heart Disease: Mechanisms, Responses, and PreventionFlorin Despa; Fiscal Year: 2013..The pilot study also suggests that endogenous molecules with anti-aggregation properties, such as plasmin and epoxyeicosanoids, limit cardiac accumulation of amylin and its myopathic response...
- MOLECULAR MECHANISMS OF FIBRINOLYSISPaul E Bock; Fiscal Year: 2013..streptococcal virulence factor, targets human fibrinolysis by activating plasminogen (Pg) to the proteinase, plasmin (Pm)...
- Multiscale, Multiphysics Model of Thrombus Biomechanics in Aortic DissectionGeorge Karniadakis; Fiscal Year: 2013..within the false lumen and that partially thrombosed dissections are dangerous because the continued release of plasmin by an intramural thrombus in contact with flowing blood can activate constitutively produced, latent matrix ..
- Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgeryFrancis G Spinale; Fiscal Year: 2012..which is commonly managed by pharmacologically modifying clot degradation (fibrinolysis), through inhibition of plasmin activity (PLact)...
- Deep Vein Thrombosis and Chronic Thrombotic Venous DiseaseTimothy A Morris; Fiscal Year: 2012..studies disclosed that fibrinogen purified from CTEPH patients is somewhat resistant to lysis by exogenous plasmin. Furthermore, we have identified specific fibrinogen mutations among CTEPH patients that may affect the structure ..
- Role of Protease Activated Receptors in Spinal Cord Injury and RepairIsobel A Scarisbrick; Fiscal Year: 2013..to establish the role of PARs in mediating the cellular effects of SCI-related PAR agonists (KLKs, thrombin and plasmin) in primary spinal cord neurons, astrocytes and oligodendroglia and their sensitivity to neurotoxic agents in ..
- Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agentsMADHU SATYA BAJAJ; Fiscal Year: 2010DESCRIPTION (provided by applicant): The goal of this proposal remains to test a novel and unique inhibitor of plasmin that has the potential to reduce severe bleeding in major surgery as well as in coagulopathy...
- Regulation of plasminogen-dependent cell functions by the novel receptor, Plg-RKTLindsey A Miles; Fiscal Year: 2013..Localization of plasminogen on cell surfaces is a crucial control point for positive regulation of cell surface plasmin proteolytic activity that facilitates both physiological and pathological processes requiring cell migration...
- Recombinant annexin A2 plus tPA for combination stroke therapyXiaoying Wang; Fiscal Year: 2013..The molecular basis for our idea is that annexin A2 accelerates the generation of clot-dissolving plasmin by assembling a fibrinolytic complex with tPA and the plasmin precursor plasminogen. Our pilot data are promising...
- Annexin 2 in Lymphoproliferative AngiogenesisJia Ruan; Fiscal Year: 2012..neo-angiogenesis by mediating vascular and stromal cell recruitment, migration, and assembly via cell surface plasmin generation and matrix metalloproteinases activation...
- Understanding the biological activity of Cthrc1 cleavage fragmentsRENEE LECLAIR; Fiscal Year: 2010..b>Plasmin is capable of cleaving Cthrd in two locations and the activity of these fragments will be assessed in vitro using ..
- A Novel Plasminogen Receptor in Breast CancerBARBARA MARIA MUELLER; Fiscal Year: 2013..the plasminogen receptor, Plg-RKT, which promotes activation of plasminogen to the broad spectrum protease, plasmin. Cell surface plasmin regulates the tumor microenvironment by effecting degradation of the ECM and release of ..
- Plasminogen Activation &SK: Structure-FunctionGuy L Reed; Fiscal Year: 2012..7 million people a year worldwide. Therapeutic dissolution of these thrombi by plasmin, an enzyme that digests fibrin, reduces death and disability from heart attacks and strokes...
- RESOLUTION OF GLOMERULOSCLEROSISAgnes B Fogo; Fiscal Year: 2013..This regression was linked to decreased matrix and restoration of plasmin. Our new preliminary data show limited long-term efficacy over six months of this intervention, indicating ..
- Control of fibroblast function by prostaglandin E2 and plasminogen activationMARC L PETERS-GOLDEN; Fiscal Year: 2013..and cyclic AMP (cAMP) effectors, and 2) the proteolytic cascade by which urokinase converts plasminogen to plasmin. We have previously shown that cross-talk between these two pathways is critical for their anti-fibrotic ..
- Designing Fibrin Microthread Scaffolds for Skeletal Muscle RegenerationJonathan M Grasman; Fiscal Year: 2013..In the wound site, fibrin degrades quickly i the presence of numerous proteinases such as plasmin. We recently developed a crosslinking strategy to modify fibrin microthreads to increase their resistance to ..
- Regulation of urokinase receptor expression in colon cancerDouglas D Boyd; Fiscal Year: 2010..The u- PAR also binds the serine protease urokinase thus increasing plasmin formation and extracellular matrix protein turnover to promote tumor cell migration/invasion...
- Nuclear urokinase (uPA) regulates tumor cell proliferation and survival.Victoria Stepanova; Fiscal Year: 2010..factor-like domain (GFD), which binds uPAR, the kringle and a protease domain which converts plasminogen into plasmin and cleaves some other substrates...
- Workshop on the Molecular and Cellular Biology of Plasminogen ActivationVictoria Ploplis; Fiscal Year: 2013..ultimately results in the proteolytic conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) (1)...
- MSCs Induce Brain Plasticity via tPAMichael Chopp; Fiscal Year: 2013..Hypothesis 3: tPA activity increased by MSCs promotes neurite remodeling via plasmin-dependent proteolytic cleavage of pro-neurotrophins: pro-nerve growth factor (pro-NGF) to NGF, pro-brain derived ..
- Corneal Repair: uPA and extracellular matrixAudrey M Bernstein; Fiscal Year: 2010..When uPA binds to its cell-surface receptor, uPAR, uPA generates plasmin at the cell-matrix interface...
- uPA/uPAR and Ro60 in the pathogenesis of congenital heart blockPARASKEVI BRIASOULI; Fiscal Year: 2013..eat me" signal to healthy cardiocytes attempting clearance of remodeling cells and the other is the generation of plasmin. Aim 1 explores the mechanisms by which anti-Ro60 exploits uPAR to inhibit apoptotic clearance. In Aim 2, Dr...
- PA/PLASMIN/GELATINASE CASCADE IN DIABETIC NEPHROPATHYWILLIAM BARICOS; Fiscal Year: 2000..that extracellular matrix degradation by cultured mesangial cells involves cooperative interactions between plasmin (generated from plasminogen by MC plasminogen activator) and mesangial cell gelatinase...
- PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPYSTEVEN GONIAS; Fiscal Year: 1993..The first aim is to understand the reaction of the thrombolytic complex, streptokinase-plasmin(ogen)(SkPl), preparations and on the importance of cofactor such as fibrinogen, fibrin digestion products and ..
- Role of Inflammatory Neutrophils and their Unique MMP-9 in Tumor ProgressionJames P Quigley; Fiscal Year: 2013..The plasminogen/plasmin serine protease cascade will be examined mechanistically for partnering with activated MMP-9 during angiogenic ..
- HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPYBARBARA ALEVRIADOU; Fiscal Year: 2000..Bach agent results in cleavage of plasminogen to plasmin. Plasmin degrades the fibrin strands and dissolves thrombi...
- Reducing Stroke by a Novel, Clot-dissolving AntibodyGUY LELAND REED; Fiscal Year: 2013..studies, we have shown that these goals might be achieved by a molecule that inactivates the major inhibitor of plasmin and, dissolves clots through a unique mechanism that avoids the risk of hemorrhage and neurotoxicity associated ..
- INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEMMichael Boyle; Fiscal Year: 2001..Studies in Dr. Boyle's laboratory have shown that group A streptococci can interact with the human plasmin(ogen) system by a number of different mechanisms to acquire surface proteolytic enzymatic activity, which cannot ..
- tPA Neurotoxicity in Hypoxic-Ischemia EncephalopathyChia Yi Kuan; Fiscal Year: 2009..Anti-plasmin treatment reduces the extent of ischemic- hypoxic brain injury, whereas the injection of exogenous tPA worsens it...
- PDGF and PVRAndrius Kazlauskas; Fiscal Year: 2012..was the predominant PDGF isoform in the vitreous of patients and experimental animals experiencing PVR, and that plasmin was the major protease that processed it to the CUB and core domains...
- ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORSSTEVEN GONIAS; Fiscal Year: 1992..b>Plasmin is the primary proteinase responsible for fibrin digestion in vivo...
- STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMINFrancis Castellino; Fiscal Year: 1999..Important new thrombolytic agents, and/or strategies for application of thrombolytic therapy to human vascular disease, is expected to directly or indirectly result from the basic knowledge provided by this work. ..
- Mechanisms of mosquito midgut invasion by Plasmodium ookinetesMarcelo Jacobs-Lorena; Fiscal Year: 2013..facilitates both ookinete docking to the surface of the midgut epithelium and tPA activation of plasminogen into plasmin (a protease)...
- REGULATION OF ANGIOGENESIS BY PAI1Daniel Lawrence; Fiscal Year: 2001..plasminogen activator (tPA) both activate the broad specificity zymogen plasminogen into its active form plasmin, and both uPA and plasmin have previously been implicated in tissue remodeling in vivo, including wound healing ..
- tPA is a Neuroprotectant in the Ischemic BrainMANUEL SALVADOR YEPES; Fiscal Year: 2013..Tissue-type plasminogen activator (tPA) is a serine proteinase that activates the zymogen plasminogen into plasmin. In the intravascular space tPA has a beneficial thrombolytic effect...
- Recombinant Des-Kringle Derivatives of Plasmin for Treatment of Peripheral ArteriXLNLI LIN; Fiscal Year: 2006..Additionally, problems with long, retracted clots and poor circulation results in depletion of available plasmin, the PA substrate, near the PAO thrombus, rendering the PA only partially effective...
- Alpha2-antiplasmin polymorphism and a new plasma enzymePatrick McKee; Fiscal Year: 2006..proposal's goal is to (1) define interactions that determine how much a2AP becomes clot-bound for inhibiting plasmin; and (2) identify means of regulating a2AP so that plasmin activity might be enhanced long-term in diseases where ..
- A New Class of Serine and Cysteine Protease InhibitorsCHRISTOPHER SETO; Fiscal Year: 2006..The serine protease plasmin plays a role in both angiogenesis and metastasis in cancer development, while PTP1B and the Yersinia PTPase are ..
- Site Directed Thrombolytic AgentELEANOR MCGOWAN; Fiscal Year: 2003..Active plasmin is generated from a stable depot form of plasmin, AZ-plasmin, by exposure to energy (light, sound waves)...
- Intrapulmonary Gene Transfer Using Compacted DNAMark Cooper; Fiscal Year: 2001..Copernicus Therapeutics has evaluated intratracheal delivery of proprietary formulations of compacted DNA (PLASmin complexes)...
- ANNEXIN II & PLASMIN MEDIATED HIGH GRADE GLIOMA INVASIONSuchitra Acharya; Fiscal Year: 2002..The plasminogen-plasmin system directly or, by activating matrix metalloproteinases (MMPs) has been implicated in the proteolytic ..
- ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROMEPojen Chen; Fiscal Year: 2007..Recently, we found 4/5 patient-derived, prothrombotic, monoclonal IgG aCL bind to plasmin, thrombin and activated protein C (APC)...