bromelains

Summary

Summary: Protein-digesting and milk-clotting enzymes found in pineapple fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. They have anti-inflammatory activity and the enzymatic activity does not disappear as the fruit ripens. (From Merck Index, 11th ed). This enzyme was formerly listed as EC 3.4.22.4.

Top Publications

  1. ncbi Bromelain: biochemistry, pharmacology and medical use
    H R Maurer
    Department of Biochemistry, Molecular Biology and Biotechnology, Institute of Pharmacy, Freie Universitat Berlin, Germany
    Cell Mol Life Sci 58:1234-45. 2001
  2. ncbi Bromelain activates murine macrophages and natural killer cells in vitro
    C R Engwerda
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    Cell Immunol 210:5-10. 2001
  3. ncbi Induction of 'molten globule' like state in acid-denatured state of unmodified preparation of stem bromelain: implications of disulfides in protein folding
    Pawan Gupta
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India
    Int J Biol Macromol 33:167-74. 2003
  4. ncbi Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 226:30-7. 2008
  5. doi Hexafluoroisopropanol-induced helix-sheet transition of stem bromelain: correlation to function
    Sandeep Dave
    Institute of Microbial Technology, Chandigarh 160036, India
    Int J Biochem Cell Biol 42:938-47. 2010
  6. ncbi Binding of antibromelain monomeric Fab' improves the stability of stem bromelain against inactivation
    Pawan Gupta
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Uttar Pradesh, India
    Biochim Biophys Acta 1646:131-5. 2003
  7. ncbi Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain
    V Grabovac
    Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria
    Int J Pharm 326:153-9. 2006
  8. ncbi In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans
    H Barth
    Department of Internal Medicine II, University of Tubingen, Tubingen, Germany
    Eur J Med Res 10:325-31. 2005
  9. ncbi Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells
    T L Mynott
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 163:2568-75. 1999
  10. ncbi Guanidine hydrochloride denaturation of glycosylated and deglycosylated stem bromelain
    Sheeba Rasheedi
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202 002, India
    Biochemistry (Mosc) 68:1097-100. 2003

Research Grants

  1. Anti-inflammatory effects of Bromelain
    ERIC SECOR; Fiscal Year: 2006
  2. LY-1 B-CELLS--DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 1993
  3. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1992
  4. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
  5. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
  6. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
  7. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
  8. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
  9. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
  10. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2007

Detail Information

Publications181 found, 100 shown here

  1. ncbi Bromelain: biochemistry, pharmacology and medical use
    H R Maurer
    Department of Biochemistry, Molecular Biology and Biotechnology, Institute of Pharmacy, Freie Universitat Berlin, Germany
    Cell Mol Life Sci 58:1234-45. 2001
    ..The claim that bromelain cannot be effective after oral administration is definitely refuted at this time...
  2. ncbi Bromelain activates murine macrophages and natural killer cells in vitro
    C R Engwerda
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    Cell Immunol 210:5-10. 2001
    ..These results indicate a potential role for bromelain in the activation of inflammatory responses in situations where they may be deficient, such as may occur in immunocompromised individuals...
  3. ncbi Induction of 'molten globule' like state in acid-denatured state of unmodified preparation of stem bromelain: implications of disulfides in protein folding
    Pawan Gupta
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India
    Int J Biol Macromol 33:167-74. 2003
    ..Biochem. Biophys. 413 (2003) 199]. Comparison suggests unfolding/folding behavior of the bromelain to be independent of the intactness of the disulfide bonds...
  4. ncbi Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 226:30-7. 2008
    ....
  5. doi Hexafluoroisopropanol-induced helix-sheet transition of stem bromelain: correlation to function
    Sandeep Dave
    Institute of Microbial Technology, Chandigarh 160036, India
    Int J Biochem Cell Biol 42:938-47. 2010
    ..This study demonstrates that hexafluoroisopropanol can induce a conformational change in stem bromelain to a form with potentially useful therapeutic properties different from those of the native protein...
  6. ncbi Binding of antibromelain monomeric Fab' improves the stability of stem bromelain against inactivation
    Pawan Gupta
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Uttar Pradesh, India
    Biochim Biophys Acta 1646:131-5. 2003
    ..Complexing with the Fab' resulted in significant stabilization of bromelain against thermal inactivation and alkaline pH...
  7. ncbi Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain
    V Grabovac
    Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria
    Int J Pharm 326:153-9. 2006
    ..This study provides evidence that heparin and bromelain form stable complexes leading to a significantly improved uptake of heparin...
  8. ncbi In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans
    H Barth
    Department of Internal Medicine II, University of Tubingen, Tubingen, Germany
    Eur J Med Res 10:325-31. 2005
    ....
  9. ncbi Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells
    T L Mynott
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 163:2568-75. 1999
    ..The results indicate that bromelain is a novel inhibitor of T cell signal transduction and suggests a novel role for extracellular proteases as inhibitors of intracellular signal transduction pathways...
  10. ncbi Guanidine hydrochloride denaturation of glycosylated and deglycosylated stem bromelain
    Sheeba Rasheedi
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202 002, India
    Biochemistry (Mosc) 68:1097-100. 2003
    ..In short, deglycosylated bromelain showed more susceptibility towards guanidine hydrochloride denaturation, indicating the contribution of the carbohydrate part of the glycoprotein to the stability of the enzyme...
  11. ncbi In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain
    Roxana Báez
    Facultad de Ciencias Medicas, Ciego de Avila, Cuba
    Planta Med 73:1377-83. 2007
    ....
  12. ncbi Modulation of growth factor binding properties of alpha2-macroglobulin by enzyme therapy
    D Lauer
    Institute of Biochemistry, University of Leipzig, Germany
    Cancer Chemother Pharmacol 47:S4-9. 2001
    ..Thus, proteinase therapy may have beneficial effects in treatment of fibrosis and certain cancers accompanied by excessively high TGF-beta concentrations...
  13. ncbi Structure-function relationship of bromelain isoinhibitors from pineapple stem
    Ken Ichi Hatano
    Department of Biological Sciences, Faculty of Engineering, Gunma University, Kiryu, Japan
    Biol Chem 383:1151-6. 2002
    ..The structural similarity between them suggests that BIs and BBI have evolved from a common ancestor and differentiated in function during the course of molecular evolution...
  14. ncbi Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial
    G H Tilwe
    Department of Medicine, GS Medical College and KEM Hospital, Mumbai
    J Assoc Physicians India 49:617-21. 2001
    ..05) in the study group receiving phlogenzym. CONCLUSION: Phlogenzym is as efficacious and well tolerated as diclofenac sodium in the management of active osteoarthrosis over three weeks of treatment...
  15. ncbi [Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling]
    V Kamenícek
    Chirurgické oddĕlení nemocnice, Bílovec
    Acta Chir Orthop Traumatol Cech 68:45-9. 2001
    ....
  16. ncbi Efficacy and safety of phlogenzym--a protease formulation, in sepsis in children
    S K Shahid
    LTMMC and LTMG Hospital and Medical College, Mumbai
    J Assoc Physicians India 50:527-31. 2002
    ..Infections are a major cause of hospitalisation wherein the host mounts an inflammatory response against the infecting agent. Administration of proteolytic enzymes could regulate the host's immune system and help early recovery from sepsis...
  17. ncbi Nuclear magnetic resonance studies on the pKa values and interaction of ionizable groups in bromelain inhibitor VI from pineapple stem
    Ken Ichi Hatano
    Department of Biological Sciences, Faculty of Engineering, Gunma University, Kiryu, Gunma 376 8515, Japan
    Biol Chem 384:93-104. 2003
    ..Furthermore, it was suggested that the ionic interaction of the inhibitor with the target enzyme is primarily important for the inhibition, which seems to involve some carboxyl groups in the inhibitor and a thiol group in the proteinase...
  18. ncbi Trifluoroethanol-induced "molten globule" state in stem bromelain
    Pawan Gupta
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India
    Arch Biochem Biophys 413:199-206. 2003
    ..Gradual transition and loss of cooperative thermal unfolding in the 60-70% (v/v) range of TFE also support the existence of the molten globule state...
  19. ncbi Characterization of genomic sequence coding for bromelain inhibitors in pineapple and expression of its recombinant isoform
    Yoriko Sawano
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 277:28222-7. 2002
    ..These results indicate that the interchain peptide plays an important role of the folding process of the mature isoinhibitors...
  20. pmc Thermal denaturation of influenza virus and its relationship to membrane fusion
    Richard M Epand
    Department of Biochemistry, McMaster Health Sciences Centre, Hamilton, ON L8N 3Z5, Canada
    Biochem J 365:841-8. 2002
    ..This temperature is lower than that required for the major endothermic peak observed in DSC experiments. The results demonstrate that there is no kinetically trapped high-energy form of HA at neutral pH...
  21. ncbi [Peculiarities of post-infarct remodeling using a complex treatment including system ensymotherapeutics]
    O V Mel'nichenko
    Voen Med Zh 328:25-30. 2007
  22. ncbi Characterization of a partially folded intermediate of stem bromelain at low pH
    Soghra Khatun Haq
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, India
    Eur J Biochem 269:47-52. 2002
    ..All the above data taken together suggest the existence of a partially folded intermediate state under low pH conditions...
  23. ncbi An inhibitive determination method for heavy metals using bromelain, a cysteine protease
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Appl Biochem Biotechnol 144:283-91. 2008
    ..23 mg 1(-1) for Cu2+. The IC50 value for Hg2+ is found to be lower to several other assays such as immobilized urease and papain assay, whilst the IC50 value for Cu2+ is lower than immobilized urease, 15-min Microtox, and rainbow trout...
  24. ncbi [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review]
    Uwe Heyll
    Abteilung Medizinische Beratung, Deutsche Krankenversicherung AG, Koln
    Med Klin (Munich) 98:609-15. 2003
    ....
  25. ncbi Effect of pH, temperature and alcohols on the stability of glycosylated and deglycosylated stem bromelain
    Rizwan Hasan Khan
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    J Biosci 28:709-14. 2003
    ..It is thus concluded that glycosylation contributes towards the functional stability of glycoenzymes...
  26. ncbi Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany
    J M Braun
    Institute of Immunology and Transfusion Medicine IKIT, Interdisciplinary Centre of Clinical Research IZKF, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    In Vivo 19:417-21. 2005
    ..This trial documents that the proteolytic pineapple enzyme Bromelain-POS is widely used in the treatment of young children diagnosed with acute sinusitis in Germany and that the use of proteolytic enzymes can benefit such patients...
  27. ncbi A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis
    U Baumhackl
    Department of Neurology, Central Clinic, St Poelten, Austria
    Mult Scler 11:166-8. 2005
    ..Three hundred and one patients with relapsing MS were enrolled in a double-blind, placebo-controlled trial. No treatment effect between the placebo and the HE groups was found either for clinical or MRI parameters...
  28. ncbi Proteinase-sensitive regions in the heavy chain of low molecular weight kininogen map to the inter-domain junctions
    R Vogel
    Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, Federal Republic of Germany
    J Biol Chem 263:12661-8. 1988
    ..The presence of kininogen heavy chain domains in plasma samples under pathologic conditions suggests that cleavage of the proteinase-sensitive regions might also occur in vivo...
  29. ncbi Combined enzymatic and antioxidative treatment reduces ischemia-reperfusion injury in rabbit skeletal muscle
    Christoph Neumayer
    Department of Vascular Surgery, Medical University of Vienna, Vienna, Austria
    J Surg Res 133:150-8. 2006
    ..The objective was to evaluate the effect of the combined antioxidative and enzymatic preparation Phlogenzym on I/R injury of skeletal muscle...
  30. ncbi Studies on the acid unfolded and molten globule states of catalytically active stem bromelain: a comparison with catalytically inactive form
    Basir Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    J Biochem 140:501-8. 2006
    ..J. Biochem. (2002) 269, 47-52]. We have shown that modification of SB for inactivation significantly affects the N-UA transition but neither affects the UA-MG transition nor the stability of the MG state...
  31. ncbi Characterization of the acidic and basic limbs of a bell-shaped pH profile in the inhibitory activity of bromelain inhibitor VI
    Ken Ichi Hatano
    Department of Biological Sciences, Faculty of Engineering, Gunma University, 1 5 1 Tenjin cho, Kiryu, Gunma 376 8515, Japan
    Biopolymers 81:309-19. 2006
    ..The result suggests that the basic limb would be affected by some electrostatic factors, probably some carboxyl groups in the target proteinase...
  32. ncbi Influence of salts and alcohols on the conformation of partially folded intermediate of stem bromelain at low pH
    Soghra Khatun Haq
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    Int J Biochem Cell Biol 37:361-74. 2005
    ..While the alcohol-induced state showed a cooperative thermal transition, the salt-induced state shows non-cooperative thermal denaturation...
  33. ncbi The catalytic mode of cysteine proteinases of papain (C1) family
    Leonidas G Theodorou
    University of Ioannina, Department of Chemistry, Laboratory of Biochemistry, 451 10 Ioannina, Greece
    Bioresour Technol 98:1931-9. 2007
    ..A hydrogen bond, which seems more likely to be developed across a pK(a)-value close to 4.00, connecting [see text] (papain/chymopapain or bromelain numbering), constitutes another novelty of this work...
  34. ncbi Protease administration decreases enhanced transforming growth factor-beta 1 content in isolated glomeruli of diabetic rats
    L Paczek
    Transplantation Institute, Warsaw School of Medicine, Nowogrodzka Street, 02-006 Warsaw, Poland
    Drugs Exp Clin Res 27:141-9. 2001
    ..03 +/- 1.12 ng/microgram DNA NS). Furthermore, a decrease in the kidney/body weight ratio (p < 0.01) was achieved. Protease administration did not affect blood glucose concentration and was without visible adverse effects...
  35. ncbi Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice
    N Manhart
    Department of Surgical Research, University Vienna, Austria
    Cell Immunol 215:113-9. 2002
    ..Moreover, PHL pretreatment decreased IFN-gamma mRNA in PPs and spleen of endotoxemic mice. These results reveal that PHL may ameliorate inflammatory process by reducing the number of CD4+ cells and by diminishing INF-gamma mRNA levels...
  36. pmc A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes
    G M M J Kerkhoffs
    Orthopaedic Research Center Amsterdam, Department of Orthopaedic Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Br J Sports Med 38:431-5. 2004
    ..To compare the effectiveness and safety of the triple combination Phlogenzym (rutoside, bromelain, and trypsin) with double combinations, the single substances, and placebo...
  37. ncbi Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs
    G Klein
    Rehabilitation Centre for Cardiovascular and Rheumatic Diseases, Saalfelden, Germany
    Clin Exp Rheumatol 24:25-30. 2006
    ..The objective of this study was to establish the non-inferiority of an oral enzyme therapy (Phlogenzym-(PE)) as compared to the non-steroidal anti-inflammatory drug (NSAID) diclofenac (DC) in patients with osteoarthritis (OA) of the hip...
  38. ncbi Identification and characterization of functional intermediates of stem bromelain during urea and guanidine hydrochloride unfolding
    Basir Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    J Biochem 141:251-9. 2007
    ..This makes stem bromelain and in general cysteine proteases an exception to the hypothesis that active site is the most labile part of enzyme...
  39. ncbi Thermal destabilization of stem bromelain by trehalose
    S Habib
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh
    Protein J 26:117-24. 2007
    ..This is perhaps the first report on the destabilization of a protein by trehalose...
  40. ncbi Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice
    Laura P Hale
    Department of Pathology, Duke University Medical Center, 213 A Davison Bldg, Box 3712, Durham, NC 27710, USA
    Int Immunopharmacol 4:255-64. 2004
    ..They provide further support for the hypothesis that oral bromelain may potentially modify inflammation within the gastrointestinal tract via local proteolytic activity within the colonic microenvironment...
  41. ncbi Effect of polyethylene glycols on the function and structure of thiol proteases
    Sadaf Fatima
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    J Biochem 142:65-72. 2007
    ..The results imply that caution must be exercised in the use of PEGs with thiol proteases or hydrophobic proteins in general, for different industrial applications, even at room temperature...
  42. ncbi [Oral enzyme therapy for chronic hepatitis C--a retrospective analysis]
    Roman Huber
    Uni Zentrum Naturheilkunde Freiburg i Br, Deutschland
    Forsch Komplementarmed Klass Naturheilkd 12:144-7. 2005
    ..In our study, we investigated whether comparable effects can be found in daily practice in German patients...
  43. ncbi [Systemic enzyme therapy as a method for potentiation of the effect of antibacterial agents]
    A P Remezov
    Medical Academy of Postgraduate Education, St Peterburg
    Antibiot Khimioter 48:30-3. 2003
  44. ncbi Characterization of different strains of poliovirus and influenza virus by differential scanning calorimetry
    Tino Krell
    Aventis Pasteur, 1541 Avenue Marcel Merieux, 69280 Marcy l Etoile, France
    Biotechnol Appl Biochem 41:241-6. 2005
    ..7 degrees C. At neutral pH, the DSC thermogram of type I poliovirus was very 'noisy'. Data obtained offer the possibility of precisely characterizing and identifying different viral strains...
  45. pmc Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa
    Carla A Guimarães-Ferreira
    Experimental Oncology Unit, Department of Microbiology, Immunology, and Parasitology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Neoplasia 9:723-33. 2007
    ..Anti-fastuosain antibodies were cytotoxic/lytic to B16F10-Nex2 cells. Antitumor effects of fastuosain involve mainly the direct effect of the enzyme and elicitation of protective antibodies...
  46. ncbi A serine proteinase inhibitor isolated from Tamarindus indica seeds and its effects on the release of human neutrophil elastase
    J M S L L Fook
    Departamento de Bioquimica, Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Campus Universitario, 59072 970, Natal, RN, Brasil
    Life Sci 76:2881-91. 2005
    ..6% and on release by fMLP, at 28.4%. These results showed that PG50 preferentially affected elastase release by PAF stimuli and this may indicate selective inhibition on PAF receptors...
  47. pmc Dose-dependent induction of IL-6 by plant-derived proteases in vitro
    B Rose
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University, Duesseldorf, Germany
    Clin Exp Immunol 143:85-92. 2006
    ..These findings might provide the mechanistic rationale for the current use of proteases in wound healing and tissue regeneration since these processes depend on IL-6 induction...
  48. ncbi Use of enzyme treatment to enhance reactivity of HLA and platelet-specific antibodies in solid-phase RBC adherence assays
    Miriam Fogg Leach
    Transfusion Service Laboratory, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Transfusion 42:476-80. 2002
    ..Solid-phase RBC adherence (SPRCA) assays (Immucor) detect HLA and/or platelet-specific antibodies. Pretreatment of reagent platelets with enzymes was investigated to determine whether the sensitivity of the assay could be increased...
  49. ncbi Plant lipases: biocatalyst aqueous environment in relation to optimal catalytic activity in lipase-catalyzed synthesis reactions
    Yanis Caro
    Lipotechny Laboratory, CIRAD AMIS, TA 40 16, 34398 Montpellier Cedex, France
    Biotechnol Bioeng 77:693-703. 2002
    ..Furthermore, the bromelain preparation is far more hydrophobic as it adsorbs only 18 g of water per 100 g of dry material at a(w) around 0.90. No deliquescence of this enzymatic preparation is observed at this a(w) value...
  50. ncbi Protease-catalyzed regioselective polymerization and copolymerization of glutamic acid diethyl ester
    Hiroshi Uyama
    Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606 8501, Japan
    Biomacromolecules 3:318-23. 2002
    ..The effects of the reaction parameters have been systematically investigated. The copolymerization of 1 with various amino acid esters took place by the papain catalyst to give peptide copolymers...
  51. ncbi Benzodioxole derivatives as negative effectors of plant proteases
    Luisa Ugolini
    CRA ISCI, Research Institute for Industrial Crops, Bologna, Italy
    J Agric Food Chem 53:7494-501. 2005
    ..Measures of octanol/water partition coefficients on PBO and PBOH have demonstrated that water solubility plays a fundamental role in the expression of protease inhibition activity...
  52. ncbi Susceptibility of the interchain peptide of a bromelain inhibitor precursor to the target proteases bromelain, chymotrypsin, and trypsin
    Yoriko Sawano
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Chem 386:491-8. 2005
    ..Bromein is also known to weakly inhibit the serine proteinases chymotrypsin and trypsin; however, a recombinant single-chain inhibitor with the interchain peptide was no longer able to inhibit these serine proteinases...
  53. ncbi Mass spectrometric sequencing and acylation character analysis of C-terminal anchoring segment from Influenza A hemagglutinin
    Marina V Serebryakova
    Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow
    Eur J Mass Spectrom (Chichester, Eng) 12:51-62. 2006
    ..Triply, doubly, mono- and even unacylated peptides were detected. It was demonstrated that the thioester bond in the isolated acylpeptides was extremely sensitive to thiol reagents...
  54. ncbi Prevalence and clinical relevance of specific immunoglobulin E to pollen caused by sting- induced specific immunoglobulin E to cross-reacting carbohydrate determinants in Hymenoptera venoms
    A M Kochuyt
    Department of Internal Medicine, Division of Allergy and Clinical Immunology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Exp Allergy 35:441-7. 2005
    ..sIgE to such cross-reacting CD (CCD) are believed to have little or no biological activity and thus may cause misdiagnosis of pollen sensitization after a sting...
  55. ncbi Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase
    Suping Wen
    Department of Health Sciences, University of Technology, Sydney, NSW 2007, Australia
    Life Sci 78:995-1002. 2006
    ..Our data indicates that bromelain may benefit patients with postoperative ileus...
  56. pmc Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium
    Bela Juhasz
    Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Am J Physiol Heart Circ Physiol 294:H1365-70. 2008
    ..These results demonstrated for the first time that Br triggers an Akt-dependent survival pathway in the heart, revealing a novel mechanism of cardioprotective action and a potential therapeutic target against I/R injury...
  57. ncbi A case of early renal functional impairment resolved with nutrients and botanicals
    Davis W Lamson
    Bastyr University, Kenmore, WA, USA
    Altern Med Rev 8:55-8. 2003
    ..Although previous use of intravenous EDTA resolved Raynaud's syndrome symptoms, it provided little improvement to abnormal creatinine clearance...
  58. ncbi Purification and characterization of phytocystatins from kiwifruit cortex and seeds
    Maysoon Rassam
    Gene Technologies, The Horticultural and Food Research Institute of New Zealand, PB 92169, Auckland, New Zealand
    Phytochemistry 65:19-30. 2004
    ..This is the first report of phytocystatins from the Ericales...
  59. doi Rapid and selective enzymatic debridement of porcine comb burns with bromelain-derived Debrase: acute-phase preservation of noninjured tissue and zone of stasis
    Adam J Singer
    Department of Emergency Medicine and the Division of Laboratory Animal Research, Stony Brook University, Stony Brook, New York, USA
    J Burn Care Res 31:304-9. 2010
    ..At 48 hours, SSD treatment resulted in superficial tissue damage and partial preservation of the unburned interspaces...
  60. ncbi Surface mapping of the ligand-filled C-terminal half of the porcine estradiol receptor by restricted proteolysis
    H H Thole
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Germany
    Eur J Biochem 231:510-6. 1995
    ..The sites exposed to proteolytic enzymes and the epitope for 13H2 attachment are in good agreement with surface probability plots...
  61. ncbi Concanavalin A binding and endoglycosidase D resistance of beta1,2-xylosylated and alpha1,3-fucosylated plant and insect oligosaccharides
    I B Wilson
    Institut für Chemie der Universität für Bodenkultur, Wien, Austria
    Glycoconj J 15:203-6. 1998
    ....
  62. ncbi Potential interactions between alternative therapies and warfarin
    A M Heck
    School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA
    Am J Health Syst Pharm 57:1221-7; quiz 1228-30. 2000
    ..Pharmacists and other health care professionals should question all patients about use of alternative therapies and report documented interactions to FDA's MedWatch program...
  63. ncbi Purification and characterization of kininogens from sheep plasma
    Shahid P Baba
    Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh 202002, India
    Protein J 24:95-102. 2005
    ..40 and 2.00 nM respectively. Binding of HMWK, LMWK1 and 2 to activated papain were accompanied by pronounced changes in secondary and tertiary structure that are compatible with perturbations of environment of aromatic residues...
  64. ncbi Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom
    W Hemmer
    FAZ Floridsdorf Allergy Centre, Vienna, Austria
    Clin Exp Allergy 34:460-9. 2004
    ..As these antibodies possibly have low clinical relevance they may be misleading in the diagnosis of venom allergy...
  65. doi The effects of rapid enzymatic debridement of deep partial-thickness burns with Debrase on wound reepithelialization in swine
    Adam J Singer
    Department of Emergency Medicine, HSC L4 080, 8350 SUNY, Stony Brook, New York 11794 8350, USA
    J Burn Care Res 31:795-802. 2010
    ..Rapid enzymatic debridement of deep partial-thickness burns with Debrase results in earlier reepithelialization and cellular proliferation in swine, when compared with carrier and topical antibiotic dressings alone...
  66. doi A comparative study of the effects of bromelain and fresh pineapple juice on the early phase of healing in acute crush achilles tendon injury
    Ayoola I Aiyegbusi
    Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria
    J Med Food 14:348-52. 2011
    ..Based on this study, 600 GDU bromelain given at a dosage of 7 mg/kg had a better effect on tenocyte proliferation than fresh pineapple juice given once daily in acute tendon injury...
  67. ncbi The antiphospholipid syndrome as a model for B cell-induced autoimmune diseases
    Pierre Youinou
    Laboratory of Immunology, Brest University Medical School Hospital, 5 av Foch CHU Morvan BP 824, F 29609 Brest Cedex, France
    Thromb Res 114:363-9. 2004
    ..Their classical view in the biology of immune responses to self as autoAb secreting cells turns out to be rather naive, and an essential role for B lymphocytes may not be producing autoAb...
  68. ncbi The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury
    Richard J Bloomer
    Department of Health and Sport Sciences, The University of Memphis, Memphis, Tennessee 38152 3480, USA
    Sports Med 37:519-32. 2007
    ....
  69. ncbi Sensitization to cross-reactive carbohydrate determinants in relation to alcohol consumption
    A Gonzalez-Quintela
    Department of Internal Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Clin Exp Allergy 38:152-60. 2008
    ..Alcohol consumption is associated with increased serum IgE of unknown specificity...
  70. ncbi Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic Escherichia coli K88 in pig intestinal cells
    M Roselli
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy
    Toxicol In Vitro 21:224-9. 2007
    ..Allicin protection was not due to its anti-bacterial activity, since ETEC growth was unaffected by the presence of allicin...
  71. ncbi Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens
    R van Ree
    Department of Allergy, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 275:11451-8. 2000
    ..On the other xylose-containing N-glycans, an additional alpha(1,3)-mannose is present. These observations indicate that IgE binding to xylose is sterically hampered by the presence of an alpha(1,3)-antenna...
  72. doi Evaluation of bitterness in enzymatic hydrolysates of soy protein isolate by taste dilution analysis
    W H Seo
    Department of Food Engineering, Dankook University, San 29, Anseo Dong, Cheonan 330 714, Korea
    J Food Sci 73:S41-6. 2008
    ..These results suggest that TDA could be applied for the alternative of bitterness evaluation to the hedonic scale sensory evaluation...
  73. ncbi Enzymatic recovery and purification of polyhydroxybutyrate produced by Ralstonia eutropha
    Fernanda M Kapritchkoff
    Agrupamento de Biotecnologia DQ, Instituto de Pesquisas Tecnológicas do Estado de São Paulo IPT, Cidade Universitaria, Av Prof Almeida Prado 532, CEP 05508 901 São Paulo, SP, Brazil
    J Biotechnol 122:453-62. 2006
    ..The molecular mass analysis of PHB showed no polymer degradation. Therefore, this work demonstrates the potential of using enzymes in order to recover and purify PHB and bacterial biopolymers in general...
  74. ncbi Attachment of influenza C virus to human erythrocytes
    H Nishimura
    Department of Bacteriology, Yamagata University School of Medicine, Japan
    J Gen Virol 69:2545-53. 1988
    ..These results, taken together, suggest that most influenza C virus receptors on human erythrocytes, if not all, reside on glycophorin A which is known to possess the M or N blood group activity...
  75. ncbi Germline V genes encode viable motheaten mouse autoantibodies against thymocytes and red blood cells
    K N Kasturi
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029
    J Immunol 145:2304-11. 1990
    ..These results indicate that antigen driven stimulation may not play an important role in the induction of anti-thymocyte antibody response in mev mouse...
  76. ncbi Skin test with a timothy grass (Phleum pratense) pollen extract vs. IgE to a timothy extract vs. IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data
    A Mari
    Allergy Unit, National Health Service, Rome, Italy
    Clin Exp Allergy 33:43-51. 2003
    ..The diagnostic approach to grass pollen allergy is now possible by detecting specific IgE to its allergenic components...
  77. ncbi Molecular characterization and allergenic activity of Lyc e 2 (beta-fructofuranosidase), a glycosylated allergen of tomato
    Sandra Westphal
    Department of Allergology, Paul Ehrlich Institut, Langen, Germany
    Eur J Biochem 270:1327-37. 2003
    ....
  78. doi Interference of cross-reactive carbohydrates in the determination of specific IgE in alcohol drinkers and strategies to minimize it: the example of latex
    Vitor Coutinho
    Instituto Superior de Saúde do Alto Ave ISAVE, Povoa de Lanhoso, Portugal
    Ann Allergy Asthma Immunol 101:394-401. 2008
    ..The prevalence of IgE to Man2XylFucGlcNAc2 (MUXF), the CCD from bromelain, may be increased in heavy drinkers...
  79. ncbi The use of proteolysis with ficin, for immunostaining of paraffin sections. A study of lymphoid, mesenchymal, and epithelial determinants in human tissues
    R E Andrade
    Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis
    Am J Clin Pathol 90:33-9. 1988
    ..With this proviso, however, ficin appeared to be the best general enhancer for antigens known to require vigorous digestion (e.g., keratin; F8RAG) for optimal reactivity in paraffin sections...
  80. pmc Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes
    Margarita D Marinova
    Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad G Bonchev Street, Building 9, BG 1113 Sofia, Bulgaria
    Enzyme Res 2010:415949. 2011
    ....
  81. ncbi Comparison of the aggregation behavior of soy and bovine whey protein hydrolysates
    Bas J H Kuipers
    Department of Agrotechnology and Food Sciences, Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Biotechnol Adv 25:606-10. 2007
    ....
  82. doi Immunoglobulin-E reactivity to wine glycoproteins in heavy drinkers
    Arturo Gonzalez-Quintela
    Department of Internal Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Alcohol 45:113-22. 2011
    ..Glycans and wine glycoprotein extracts can induce basophil activation in sensitized alcoholics. The clinical significance of these findings remains to be elucidated...
  83. ncbi Purification and characterization of buffalo brain cystatin
    Fakhra Amin
    Department of Forensic Medicine IBRC, J N Medical College Aligarh Muslim University Aligarh, U P 202002, India
    Protein Pept Lett 18:210-8. 2011
    ..Cystatins are thiol proteinase inhibitors ubiquitously present in mammalian body and serve various important physiological functions...
  84. doi Protease-catalyzed oligomerization of hydrophobic amino acid ethyl esters in homogeneous reaction media using l-phenylalanine as a model system
    Kodandaraman Viswanathan
    Department of Chemical and Biological Science, NSF I UCRC for Biocatalysis and Bioprocessing of Macromolecules, Polytechnic Institute of NYU, Six Metrotech Center, Brooklyn, New York 11201, USA
    Biomacromolecules 11:2152-60. 2010
    ..DP(avg) and chain length distribution in the product peptides were investigated by (1)H NMR and MALDI-TOF...
  85. ncbi Irritant contact dermatitis from plants
    Gunjan M Modi
    Baylor College of Medicine, Houston, TX, USA
    Dermatitis 20:63-78. 2009
    ..We also review mechanisms for the development of ICD and current treatments for ICD from plants...
  86. doi [Cross-reactivity to honeybee and wasp venom]
    W Hemmer
    FAZ Floridsdorfer Allergiezentrum, Franz Jonas Platz 8 6, 1210, Wien
    Hautarzt 59:194-9. 2008
    ..Future in-vitro diagnosis will be markedly improved when recombinant allergens lacking CCDs become commercially available...
  87. ncbi Botanical ingredients in cosmeceuticals
    Leslie Baumann
    Division of Cosmetic Dermatology, University of Miami Cosmetic Center, Miami, FL 33140, USA
    J Drugs Dermatol 6:1084-8. 2007
    ..Other botanical agents, such as arnica, bromelain, chamomile, pomegranate, caffeine, green tea, licorice, and resveratrol, are also briefly considered. Some of these ingredients have been incorporated into topical formulations...
  88. ncbi Fagales pollen sensitization in a birch-free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4)
    A Mari
    Allergy Unit, National Health Service, Rome, Italy
    Clin Exp Allergy 33:1419-28. 2003
    ..Little is known about birch sensitivity in areas without birch pollen exposure and reactivity to birch-related species within the Fagales order...
  89. doi Component-resolved diagnosis from latex allergy by microarray
    D G Ebo
    Department of Immunology Allergology Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Clin Exp Allergy 40:348-58. 2010
    ..A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy...
  90. ncbi Clitocypin, a new type of cysteine proteinase inhibitor from fruit bodies of mushroom clitocybe nebularis
    J Brzin
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    J Biol Chem 275:20104-9. 2000
    ..The inhibitor, which is present in at least two other members of the Clitocybe genus, has been named clitocypin (Clitocybe cysteine proteinase inhibitor)...
  91. ncbi Multiple pollen sensitization: a molecular approach to the diagnosis
    A Mari
    Allergy Unit, National Health Service, Rome, Italy
    Int Arch Allergy Immunol 125:57-65. 2001
    ..Sensitization to multiple pollen species is a frequent diagnostic event. Several allergenic molecules with a high level of homology have been identified in divergent pollen families and named panallergens...
  92. doi Metastability of papain and the molecular mechanism for its sequential acid-denaturation
    Rosa Eréndira Fosado-Quiroz
    Universidad Autonoma de San Luis Potosi, Coordinación Académica Región Altiplano, COARA, Carretera a Cedral Km 5 600, Ejido San José de las Trojes, 78700 Matehuala, San Luis Potosi, Mexico
    Protein J 30:184-93. 2011
    ....
  93. ncbi Blocking of protease allergens with inhibitors reduces allergic responses in allergic rhinitis and other allergic diseases
    Motohiko Suzuki
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Acta Otolaryngol 126:746-51. 2006
    ..Allergic responses specific to the corresponding proteases were reduced by protease inhibitors, suggesting promise as potent treatments for allergic rhinitis and other allergic conditions...
  94. ncbi Herbal medicines for the treatment of rhinosinusitis: a systematic review
    Ruoling Guo
    Department of Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, United Kingdom
    Otolaryngol Head Neck Surg 135:496-506. 2006
    ..To assess the efficacy of herbal medicines for treating rhinosinusitis...
  95. ncbi Atomic force microscopy investigation of the giant mimivirus
    Yuri G Kuznetsov
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Virology 404:127-37. 2010
    ..These are probably contained within the capsid along with the DNA bearing sac. The fibers were occasionally observed associated with toroidal protein clusters interpreted as processive enzymes modifying the fibers...
  96. doi Amperometric immunosensor for detection of celiac disease toxic gliadin based on Fab fragments
    Hossam M Nassef
    Nanobiotechnology and Bioanalysis Group, Department of Chemical Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Anal Chem 81:5299-307. 2009
    ..29 ng/mL. The Fab based immunosensor offers the advantages of being highly sensitive, easy, and rapid to prepare, with a low assay time...
  97. doi Evaluation of the effects of various chemicals on discharge of and pain caused by jellyfish nematocysts
    Laura M Birsa
    Skidaway Institute of Oceanography, 10 Ocean Science Circle, Savannah, GA 31411, USA
    Comp Biochem Physiol C Toxicol Pharmacol 151:426-30. 2010
    ..Thus lidocaine in addition to acting as an anesthetic on skin in contact with jellyfish tentacles inhibited nematocyst discharge possibly by blocking sodium and/or calcium channels of the nematocytes...
  98. ncbi A pathogenic monoclonal antibody, G8, is characteristic of antierythrocyte autoantibodies from Coombs'-positive NZB mice
    M J Caulfield
    Section of Immunology, Cleveland Clinic Foundation, OH 44195
    J Immunol 148:2068-73. 1992
    ..The results suggest Coombs'-positive autoantibodies from NZB mice are not derived from "natural" antibodies, but rather, consist of a restricted set of autoantibodies expressing the G8 IdX...
  99. doi An alternative method for preparation of pandemic influenza strain-specific antibody for vaccine potency determination
    Falko Schmeisser
    Division of Viral Products, Center for Biologics Evaluations and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, United States
    Vaccine 28:2442-9. 2010
    ....
  100. pmc Online intelligent controllers for an enzyme recovery plant: design methodology and performance
    M S Leite
    School of Chemical Engineering, Department of Chemical Systems Engineering, University of Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
    Enzyme Res 2010:250843. 2010
    ..The fuzzy PI controller exhibited a reduced error parameter (ITAE), lower power consumption, and better recovery of enzyme activity...
  101. ncbi Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy
    Jeanne M Wallace
    Nutritional Solutions, Inc, 2935 North, 1000 East, North Logan, UT 84341, USA
    Integr Cancer Ther 1:7-37; discussion 37. 2002
    ....

Research Grants58

  1. Anti-inflammatory effects of Bromelain
    ERIC SECOR; Fiscal Year: 2006
    ..2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease. ..
  2. LY-1 B-CELLS--DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 1993
    ..This work may eventually help us to understand the relationship of special features of fetal B cell development with autoreactivity nd B cell neoplasia...
  3. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1992
    ..Specificities encoded by these V genes to be examined in detail will include both anti-thymocyte and anti-bromelain-treated mouse erythrocyte autoantibodies, both distinctively enriched in this population...
  4. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  5. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  6. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  7. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  8. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  9. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..If indicated, follow-up studies will be aimed at determining the mechanisms underlying mast cell activity in IBD as well as more rigorous studies of the efficacy of mast cell inhibitors for therapy of established IBD. ..
  10. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2007
    ....
  11. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2010
    ....
  12. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2010
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  13. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2009
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  14. Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
    Robert Sackstein; Fiscal Year: 2007
    ..It is anticipated that the results obtained will lead to new approaches for preventing or alleviating G-CSF-induced vascular and inflammatory complications ..
  15. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2007
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  16. MOLECULAR ANALYSIS OF HEMATOPOIETIC L SELECTIN LIGAND
    Robert Sackstein; Fiscal Year: 2000
    ....
  17. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    ....
  18. Analysis of Homing Receptors on Human Adult Stem Cells
    Robert Sackstein; Fiscal Year: 2006
    ....
  19. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2006
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..