cathepsin e

Summary

Summary: An aspartic endopeptidase of the hydrolase class that is similar to cathepsin D but has a slightly broader specificity. EC 3.4.23.34.

Top Publications

  1. ncbi Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report
    T Azuma
    Second Department of Internal Medicine, Fukui Medical School, Japan
    Int J Cancer 67:492-7. 1996
  2. doi Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gut 61:1315-22. 2012
  3. ncbi Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages
    Michiyo Yanagawa
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Biol Chem 282:1851-62. 2007
  4. doi Cathepsin E: a mini review
    Nousheen Zaidi
    Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tuebingen, Germany
    Biochem Biophys Res Commun 367:517-22. 2008
  5. ncbi Cathepsin E (EC 3.4.23.34)--a review
    Michał Chlabicz
    Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Poland
    Folia Histochem Cytobiol 49:547-57. 2011
  6. ncbi Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing
    G Finzi
    Department of Human Pathology and Genetics, II Medical Faculty, University of Pavia, Varese, Italy
    Histochemistry 99:201-11. 1993
  7. doi Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis
    Atsushi Yasukochi
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Chem 391:947-58. 2010
  8. doi The role of cathepsin E in terminal differentiation of keratinocytes
    Tomoyo Kawakubo
    Proteolysis Research Laboratory, Department of Pharmacology, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Biol Chem 392:571-85. 2011
  9. ncbi Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
    Tomoyo Kawakubo
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Cancer Res 67:10869-78. 2007
  10. ncbi Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses
    Masashi Shin
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Biol Chem 388:1173-81. 2007

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report
    T Azuma
    Second Department of Internal Medicine, Fukui Medical School, Japan
    Int J Cancer 67:492-7. 1996
    Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Cathepsin E (CTSE) is a non-secretory, intracellular, but non-lysosomal proteinase found in the highest concentration in the superficial ..
  2. doi Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gut 61:1315-22. 2012
    ..This study assessed the feasibility of using the enzymatic activity of cathepsin E (Cath E), a protease highly and specifically expressed in PDAC, as a novel biomarker for the detection of ..
  3. ncbi Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages
    Michiyo Yanagawa
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Biol Chem 282:1851-62. 2007
    b>Cathepsin E, an endolysosomal aspartic proteinase predominantly expressed in cells of the immune system, has an important role in immune responses. However, little is known about the precise roles of cathepsin E in this system...
  4. doi Cathepsin E: a mini review
    Nousheen Zaidi
    Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tuebingen, Germany
    Biochem Biophys Res Commun 367:517-22. 2008
    b>Cathepsin E is a major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway...
  5. ncbi Cathepsin E (EC 3.4.23.34)--a review
    Michał Chlabicz
    Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Poland
    Folia Histochem Cytobiol 49:547-57. 2011
    b>Cathepsin E belongs to the third class of enzymes - hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites...
  6. ncbi Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing
    G Finzi
    Department of Human Pathology and Genetics, II Medical Faculty, University of Pavia, Varese, Italy
    Histochemistry 99:201-11. 1993
    A specific rabbit anti-human serum was used selectively to localize the aspartic proteinase cathepsin E to follicle associated epithelium (FAE) of human and rat intestine, including jejunum, ileum, appendix, colon and rectum, as well as ..
  7. doi Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis
    Atsushi Yasukochi
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Chem 391:947-58. 2010
    We previously described that cathepsin E specifically induces growth arrest and apoptosis in several human prostate cancer cell lines in vitro by catalyzing the proteolytic release of soluble tumor necrosis factor-related apoptosis-..
  8. doi The role of cathepsin E in terminal differentiation of keratinocytes
    Tomoyo Kawakubo
    Proteolysis Research Laboratory, Department of Pharmacology, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Biol Chem 392:571-85. 2011
    b>Cathepsin E (CatE) is predominantly expressed in the rapidly regenerating gastric mucosal cells and epidermal keratinocytes, in addition to the immune system cells. However, the role of CatE in these cells remains unclear...
  9. ncbi Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
    Tomoyo Kawakubo
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Cancer Res 67:10869-78. 2007
    The aspartic proteinase cathepsin E is expressed predominantly in cells of the immune system and highly secreted by activated phagocytes, and deficiency of cathepsin E in mice results in a phenotype affecting immune responses...
  10. ncbi Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses
    Masashi Shin
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Biol Chem 388:1173-81. 2007
    b>Cathepsin E (CE) is an intracellular aspartic proteinase implicated in various physiological and pathological processes, yet its actual roles in vivo remain elusive...
  11. ncbi Association of cathepsin E deficiency with development of atopic dermatitis
    Takayuki Tsukuba
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Higashi ku, Fukuoka 812 8582
    J Biochem 134:893-902. 2003
    ..Here we show that mice lacking the endolysosomal aspartic proteinase cathepsin E spontaneously develop skin lesions similar to those of humans with AD when reared under conventional conditions ..
  12. ncbi A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
    Nousheen Zaidi
    Medical and Natural Sciences Research Centre, University of Tubingen, and Children s Hospital Department I, Germany
    FEBS J 274:3138-49. 2007
    b>Cathepsin E (CatE) and D (CatD) are the major aspartic proteinases in the endolysosomal pathway...
  13. ncbi The expression and function of cathepsin E in dendritic cells
    Benjamin M Chain
    Department of Immunology and Molecular Pathology, University College London, London, United Kingdom
    J Immunol 174:1791-800. 2005
    b>Cathepsin E is an aspartic proteinase that has been implicated in Ag processing within the class II MHC pathway...
  14. ncbi Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E
    K Bennett
    Department of Biology, University College London, GB
    Eur J Immunol 22:1519-24. 1992
    ..However, the enzymes responsible for antigen processing remain largely undefined. In this study we show that cathepsin E, and not the ubiquitous lysosomal cathepsin D, is the major aspartic proteinase in a murine antigen-presenting ..
  15. ncbi Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds
    Senarath B P Athauda
    School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Protein Pept Lett 9:15-22. 2002
    In order to clarify the potential role of cathepsin E at neutral pH, the cleavage specificity of human cathepsin E was examined at pH 7.4 toward reduced-carboxymethylated(RCm-)ribonuclease A and various bioactive and related peptides...
  16. ncbi Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library
    Mohammed Naimuddin
    Rational Evolutionary Design of Advanced Biomolecules REDS, Saitama Small Enterprise Promotion Corporation, SKIP City, 3 12 18 Kamiaoki, Kawaguchi, Saitama 333 0844, Japan
    J Mol Recognit 20:58-68. 2007
    ..based on binding function while the second enrichment step was based on the inhibitory activity to a protease, cathepsin E (CE)...
  17. doi Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E
    Koichiro Kitamura
    Rational Evolutionary Design of Advanced Biomolecules, Saitama REDS, Saitama Small Enterprise Promotion Corporation, 552, Saitama Industrial Technology Center, 3 12 18 Kami Aoki, Kawaguchi, Saitama 333 0844, Japan
    J Mol Biol 387:1186-98. 2009
    ..Using this system, we generated peptides that inhibit cathepsin E (CE) specifically at a submicromolar IC(50)...
  18. ncbi Role of N-glycosylation in cathepsin E. A comparative study of cathepsin E with distinct N-linked oligosaccharides and its nonglycosylated mutant
    Y Yasuda
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Eur J Biochem 266:383-91. 1999
    b>Cathepsin E (CE), a nonlysosomal, intracellular aspartic proteinase, exists in several molecular forms that are N-glycosylated with high-mannose and/or complex-type oligosaccharides...
  19. ncbi Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia
    Tsuyoshi Nishioku
    Department of Pharmacology, Graduate School of Dental Science, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 277:4816-22. 2002
    We have attempted to elucidate an involvement of cathepsin E (CE) in major histocompatibility complex class II-mediated antigen presentation by microglia...
  20. pmc Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation
    Jason C Kwan
    Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA
    J Med Chem 52:5732-47. 2009
    ..C (3), which consists of two fewer residues than 1 and 2, was less potent against both but still selective for cathepsin E. The selectivity of compounds 1-3 for cathepsin E over D (20-38-fold) suggests that these natural products may ..
  21. ncbi Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation
    S Igarashi
    Cosmetics Laboratory, Kanebo Ltd, 5 3 28 Kotobuki cho, Odawara, Kanagawa 250 0002, Japan
    Br J Dermatol 151:355-61. 2004
    ..Identification of this aspartic proteinase by using enzyme inhibitors suggested it to be cathepsin D, although we could not exclude cathepsin E.
  22. ncbi Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases
    Paola Matarrese
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome 00161, Italy
    FASEB J 19:416-8. 2005
    ..Active protease cathepsin E and mu-calpain increased; activation of caspase 2 and caspase 3 was detected; and phosphatidylserine ..
  23. ncbi Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293
    Maria G Cappiello
    Discovery Biology, Concurrent Pharmaceuticals, 502 W Office Center Drive, Fort Washington, PA 19034, USA
    Protein Expr Purif 37:53-60. 2004
    A cDNA encoding human prepro-cathepsin E was introduced into the adenovirus-transformed HEK-293 (human embryonic kidney) cell line. The construct contained both a V5 peptide epitope and histidine tags at the carboxy terminus...
  24. doi Association of cathepsin E deficiency with the increased territorial aggressive response of mice
    Naoki Shigematsu
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Neurochem 105:1394-404. 2008
    b>Cathepsin E is an endolysosomal aspartic proteinase predominantly expressed in cells of the immune system, but physiological functions of this protein in the brain remains unclear...
  25. ncbi Transient forebrain ischemia induces increased expression and specific localization of cathepsins E and D in rat hippocampus and neostriatum
    H Nakanishi
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Exp Neurol 121:215-23. 1993
    ..While significant amounts of cathepsin D were found in both the hippocampus and the neostriatum of normal rats, cathepsin E was barely detectable in these tissues...
  26. ncbi Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32
    T Azuma
    Department of Molecular Biology and Genetics, Wayne State University School of Medicine, Detroit, Michigain 48201
    J Biol Chem 267:1609-14. 1992
    Genomic clones containing portions of the human cathepsin E (CTSE) gene were isolated from cosmid and lambda recombinant libraries...
  27. ncbi Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues
    H Nakanishi
    Department of Pharmacology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Exp Neurol 126:119-28. 1994
    ..With regard to two aspartic proteinases, cathepsin E was barely detectable in all the brain tissues of young adult rats, including the cerebral cortex, the ..
  28. ncbi Increased expression of cathepsins E and D in reactive microglial cells associated with spongiform degeneration in the brain stem of senescence-accelerated mouse
    T Amano
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Exp Neurol 136:171-82. 1995
    ..Although CE was not detectable even in the atrophied cortical area of SAMP10, CD contents in the cerebral cortex slightly increased with senescence in all three strains.(ABSTRACT TRUNCATED AT 400 WORDS)..
  29. ncbi Cathepsin E: a novel target for regulation by class II transactivator
    Christina S K Yee
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 172:5528-34. 2004
    The aspartic proteinase cathepsin E (CatE) has been implicated in Ag processing. In this study we report that CatE expression is negatively regulated by the MHC class II transactivator (CIITA)...
  30. ncbi Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors
    Takayuki Tsukuba
    Departments of Pharmacology, Pediatric Dentistry, and Fixed Prosthodontics, Graduate School of Dental Science, Kyushu University, Fukuoka 812 8582
    J Biochem 140:57-66. 2006
    b>Cathepsin E, an intracellular aspartic proteinase, is predominantly localized in the endosomal compartments of immune system cells...
  31. doi Emerging functional roles of cathepsin E
    Nousheen Zaidi
    Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany
    Biochem Biophys Res Commun 377:327-30. 2008
    b>Cathepsin E is an intracellular aspartic protease of the endolysosomal pathway. It has been implicated in several physiological and pathological processes however, its exact functional role is yet to be elucidated...
  32. ncbi Isolation, characterization, and structure of procathepsin E and cathepsin E from the gastric mucosa of guinea pig
    T Kageyama
    Department of Cellular and Molecular Biology, Kyoto University, Aichi, Japan
    Adv Exp Med Biol 362:211-21. 1995
  33. ncbi [Involvement of cathepsin D and cathepsin E in the inhibition of tumor growth and metastasis through the production of angiogenetic inhibitors]
    Jun ichi Iwata
    Tanpakushitsu Kakusan Koso 48:1928-33. 2003
  34. ncbi Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases
    Fiona Gruninger-Leitch
    Hoffmann La Roche Ltd, Grenzacherstrasse 124, CNS Research, CH 4070 Basel, Switzerland
    J Biol Chem 277:4687-93. 2002
    ..002 s(-1); Swedish mutant, SEVNL/DAEFR, K(m) = 9 microm, K(cat) = 0.02 s(-1)). A new substrate (VVEVDA/AVTP, K(m) = 1 microm, K(cat) = 0.004) was identified by serendipity...
  35. ncbi Generation of human endothelin by cathepsin E
    W E Lees
    Department of Biochemistry, University of Wales College of Cardiff, UK
    FEBS Lett 273:99-102. 1990
    ..By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical ..
  36. ncbi Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man
    Tang Li
    Department of Pathobiology, University of Florida, P O Box 110880, Gainesville, FL 32611 0880, USA
    Mol Biochem Parasitol 135:101-9. 2004
    ..falciparum having Ser in P3' had the lowest Ki of the series of inhibitors prepared, but did not significantly improve the selectivity of the inhibitor for plasmepsin 4 versus human cathepsin D...
  37. ncbi Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin
    S B Athauda
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    FEBS Lett 292:53-6. 1991
    Proteolytic activity and cleavage specificity of cathepsin E were investigated in a wide range of pHs from 3.0 to 10.5 using the B chain of oxidized insulin as substrate...
  38. ncbi Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes
    Juan Zou
    MRC Centre for Inflammation Research Renal Autoimmunity, University of Edinburgh, Edinburgh, UK
    J Am Soc Nephrol 18:771-9. 2007
    ..These observations can explain why the mature T cell repertoire includes reactivity toward these self-peptides and suggests that a key factor in disease initiation is likely to be a shift in antigen processing...
  39. ncbi An immunocytochemical study on distinct intracellular localization of cathepsin E and cathepsin D in human gastric cells and various rat cells
    T Saku
    Department of Pathology, Niigata University School of Dentistry
    J Biochem 110:956-64. 1991
    ..D was exclusively confined to primary or secondary lysosomes in almost all the cell types tested, whereas cathepsin E was not detected in the lysosomal system. The localization of cathepsin E varied with different cell types...
  40. ncbi The role of the cathepsin E propeptide in correct folding, maturation and sorting to the endosome
    Yoshiyuki Yasuda
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Higashi ku, Fukuoka 812 8582
    J Biochem 138:621-30. 2005
    b>Cathepsin E (CE) is an endosomal aspartic proteinase of the A1 family that is highly homologous to the lysosomal aspartic proteinase cathepsin D (CD)...
  41. ncbi Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease
    W Zhou
    Department of Neurosurgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0515, USA
    Neuroscience 143:689-701. 2006
    ..The current study used biochemical and immunohistochemical methods to examine whether cathepsin D (catD) and cathepsin E (catE), candidate aspartic proteases, may be involved in apoE proteolysis...
  42. ncbi Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells
    Matthew Cook
    School of Biosciences, Cardiff University, P O Box 911, Cardiff CF10 3US, Wales, UK
    Biochim Biophys Acta 1577:10-6. 2002
    ....
  43. ncbi Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E
    K Okamoto
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Arch Biochem Biophys 322:103-11. 1995
    b>Cathepsin E (CE) is an intracellular, nonlysosomal aspartic proteinase consisting of two identical subunits with a molecular mass of approximately 42 kDa and has a unique subcellular distribution in various rat tissues...
  44. ncbi Rabbit procathepsin E and cathepsin E. Nucleotide sequence of cDNA, hydrolytic specificity for biologically active peptides and gene expression during development
    T Kageyama
    Department of Cellular and Molecular Biology, Kyoto University, Japan
    Eur J Biochem 216:717-28. 1993
    ..To our knowledge, this is the first case of such a variation in aspartic proteinases. The processed form, cathepsin E, hydrolyzed various biologically active peptides maximally at around pH5...
  45. ncbi An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells
    Peter J Tatnell
    School of Biosciences of Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    Biochim Biophys Acta 1625:203-6. 2003
    ..As a result of the precise splicing of the 3'-end of exon 6 to the 5'-end of exon 8, the variant lacked the 142 bp of exon 7 which encodes the second of the Asp residues that operate the catalytic mechanism of aspartic proteinases...
  46. ncbi The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?
    G J Clements
    Celltech Ltd, Slough, Berkshire, England
    AIDS Res Hum Retroviruses 7:3-16. 1991
    ..that thrombin and tryptase cleave HIV-1 gp120 specifically at the tryptic site (GPGR decreases AFVT), and that cathepsin E, an endosomal aspartic proteinase, cleaves at the chymotrypsinlike site (GPGRAF decreases VT)...
  47. ncbi Crystal structure of an activation intermediate of cathepsin E
    Nils Ostermann
    Protease Platform, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    J Mol Biol 342:889-99. 2004
    b>Cathepsin E is an intracellular, non-lysosomal aspartic protease expressed in a variety of cells and tissues...
  48. ncbi Hemoglobin-degrading plasmepsin II is active as a monomer
    Jun Liu
    Departments of Molecular Microbiology and Medicine, Washington University School of Medicine, Howard Hughes Medical Institute, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 281:38682-8. 2006
    ..A hydrophobic loop at the PM II monomer surface, which would be buried in a PM II dimer, is shown to be essential for the hemoglobin degradation capability of PM II...
  49. ncbi Regulation of cathepsin E expression during human B cell differentiation in vitro
    L Sealy
    Department of Immunology, UCL Medical School, London, GB
    Eur J Immunol 26:1838-43. 1996
    b>Cathepsin E is an aspartic proteinase which has been implicated in antigen processing in the class II major histocompatibility complex pathway...
  50. ncbi Tissue- and cell-specific control of guinea pig cathepsin E gene expression
    S Tsukada
    1st Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 187:1401-8. 1992
    Northern blotting of RNAs from normal guinea pig tissues revealed that the tissue distribution of cathepsin E mRNA was relatively limited and the highest level of the mRNA was observed in the stomach mucosa...
  51. ncbi Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia
    D F Sastradipura
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    J Neurochem 70:2045-56. 1998
    b>Cathepsin E is a major nonlysosomal, intracellular aspartic proteinase that localizes in various cellular compartments such as the plasma membrane, endosome-like organelles, and the endoplasmic reticulum (ER)...
  52. doi Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages
    Gerald M Misinzo
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Belgium
    Vet Res 39:55. 2008
    ..Further investigation using specific inhibitors indicated that the aspartic protease cathepsin E is involved during PRRSV uncoating, but did not allow identification of the serine protease involved...
  53. pmc Protective role of interleukin-10 in ozone-induced pulmonary inflammation
    Gillian S Backus
    National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:1721-7. 2010
    ..The mechanisms underlying ozone (O₃)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators...
  54. ncbi A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A
    Nousheen Zaidi
    Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany
    Biochem Biophys Res Commun 364:243-9. 2007
    Selective inhibition of enzymes involved in antigen processing such as cathepsin E and cathepsin D is a valuable tool for investigating the roles of these enzymes in the processing pathway...
  55. ncbi Xenin--a review
    G E Feurle
    DRK Krankenhaus Neuwied, Germany
    Peptides 19:609-15. 1998
    ..revealed that xenin represents the N terminus of a cytosolic coat protein (alpha-COP) from which xenin can be cleaved by aspartic proteinases such as pepsin and cathepsin E. The physiological role of the peptide xenin is not known.
  56. ncbi Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers
    Chouhei Sakakura
    Surgery and Regenerative Medicine, Kyoto Prefectural University of Medicine, Japan
    Clin Cancer Res 11:6479-88. 2005
    ..Changes in metastatic potential were assessed in animal experiments using stable RUNX3 transfectants of gastric cancer cells. Finally, global expression changes were analyzed using a cDNA microarray...
  57. ncbi Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases
    Christoph Binkert
    Actelion Pharmaceuticals Ltd Gewerbestrasse 16, 4123 Allschwil, Switzerland
    Chembiochem 7:181-6. 2006
    ..nanomolar inhibitory activity against PM II, but were markedly less active against PM IV, cathepsin D and cathepsin E. Secondly, the X-ray crystal structures of the three complexes of PM II with 1, 2 and pepstatin A were obtained ..
  58. ncbi Oestrogen-induced expression of a novel liver-specific aspartic proteinase in Danio rerio (zebrafish)
    Marilisa Riggio
    Department of Evolutionary and Comparative Biology, University of Naples Federico II, Napoli, Italy
    Gene 295:241-6. 2002
    ..They include related paralogous proteins such as cathepsin D, cathepsin E and pepsin...
  59. ncbi Cathepsin D is specifically inhibited by deoxyribonucleic acids
    Masahiro Shibata
    Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    FEBS Lett 517:281-4. 2002
    ..b>Cathepsin E activity was also inhibited by DNA fragments when hemoglobin was used as a substrate...
  60. pmc A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier
    Marites P Melancon
    Department of Experimental Diagnostic Imaging Box 57, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA
    Pharm Res 24:1217-24. 2007
    ..To develop an L-PG-based imaging probe suitable for assessing the degradation of L-PG in vivo...
  61. ncbi Distal substrate interactions enhance plasmepsin activity
    Eva S Istvan
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:6890-6. 2005
    ..The same residues influence degradation of Hb by PM II. Cathepsin E (CatE), a related mammalian aspartic protease, is also stimulated by N-terminally extended substrates...
  62. ncbi Pregnancy associated glycoproteins in ruminants: inactive members of the aspartic proteinase family
    J F Beckers
    University of Liege, Faculty of Veterinary Medicine, Physiology of Reproduction, Sart Tilman, Belgium
    Acta Vet Hung 47:461-9. 1999
    ..Pepsinogen, renin, cathepsin E & D and chymosine are typical members of this family, characterised by the presence of aspartic acids ..
  63. pmc Identification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase family
    S C Xie
    Department of Animal Sciences, University of Missouri, Columbia 65211
    Proc Natl Acad Sci U S A 88:10247-51. 1991
    ..aspartic proteinase family and has greater than 50% amino acid sequence identity to pepsin, cathepsin D, and cathepsin E. The inferred sequences of the ovine and bovine polypeptides show approximately 73% identity to each other...
  64. pmc The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    Brian C Lewis
    University of Massachusetts Medical School, 364 Plantation St, LRB 521, Worcester, MA 01605, USA
    Mol Cell Biol 25:1228-37. 2005
    ..Some of these genes, such as cathepsin E and Igf2, have been previously implicated in tumor cell migration and invasion...
  65. ncbi [Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats]
    Hui rong Xu
    Department of Pathology, Hebei United University, Tangshan, Hebei Province 063000, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30:45-51. 2012
    ..genes between silicotic lung tissue and normal lung tissue, to identify the differentially expressing genes of matrix metalloproteinase-12 (MMP-12) and Cathepsin E and to explore the roles of those genes in silicosis development.
  66. pmc Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases
    Rebecca E Moose
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Biochemistry 46:14198-205. 2007
    ..been shown to be a competitive inhibitor of a subgroup of aspartic proteinases: pepsin, gastricsin and cathepsin E. The previously determined crystal structure of the complex of PI3 with porcine pepsin (p...
  67. ncbi [Atopic dermatitis and cathepsin E]
    Takayuki Tsukuba
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Nihon Yakurigaku Zasshi 122:15-20. 2003
    b>Cathepsin E is an intracellular aspartic proteinase expressed predominantly in immune cells and skin...
  68. ncbi SPR imaging biosensor for aspartyl cathepsins: sensor development and application for biological material
    Ewa Gorodkiewicz
    Department of Electrochemistry, Institute of Chemistry, University of Bialystok, Al J Pilsudskiego11 4, 15 443 Bialystok, Poland
    Protein Pept Lett 17:1148-54. 2010
    ..In order to demonstrate the sensor's potential, Cat E was determined in human red blood cells, Cat D in human saliva, as well as total concentration of Cat D and Cat E in human nasal polyps...
  69. doi Cathepsin E, maspin, Plk1, and survivin are promising prognostic protein markers for progression in non-muscle invasive bladder cancer
    Niels Fristrup
    Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
    Am J Pathol 180:1824-34. 2012
    ..In this study, we investigated the prognostic value of the protein expression of cathepsin E, maspin, polo-like kinase 1 (Plk1), and survivin in patients with stage Ta and T1 urothelial carcinomas...
  70. ncbi Regulation of human and mouse procathepsin E gene expression
    M Cook
    School of Biosciences, Cardiff University, Wales, UK
    Eur J Biochem 268:2658-68. 2001
    b>Cathepsin E is an intracellular aspartic proteinase that is considered to have a number of physiological roles including antigen processing...
  71. pmc A quantitative proteomics design for systematic identification of protease cleavage events
    Francis Impens
    Department of Medical Protein Research, VIB, B 9000 Ghent, Belgium
    Mol Cell Proteomics 9:2327-33. 2010
    ....
  72. ncbi Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E
    Jian Liu
    Departments of Pharmacology and Oral Surgery I, Graduate School of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biochem 132:493-9. 2002
    b>Cathepsin E, an intracellular aspartic proteinase of the pepsin family, is composed of two homologous domains, each containing the catalytic Asp residue in a consensus DTG motif...
  73. doi Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E
    Carolin Pilzner
    Department of Pneumology, Hannover Medical School, Hannover, Germany
    Int Arch Allergy Immunol 159:367-83. 2012
    ..The processing and presentation of exogenous antigens is important in the sensitization to an allergen. Cathepsin E (Ctse) is an intracellular aspartic endoprotease which is expressed in immune cells like dendritic cells (DCs)...
  74. pmc Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH
    Masayuki Komatsu
    Department of Functional Materials Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo okubo, Sakura ku, Saitama shi, Saitama 338 8570, Japan Rational Evolutionary Design of Advanced Biomolecules, Saitama REDS, Saitama Small Enterprise Promotion Corporation, No 552, Saitama Industrial Technology Center, 3 12 18 Kami Aoki, Kawaguchi, Saitama 333 0844, Japan
    Int J Pept 2012:316432. 2012
    ..These selected peptides also underwent molecular evolution, after which their cathepsin E activation capability improved...
  75. ncbi Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays
    Noriyoshi Fukushima
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Oncogene 23:9042-51. 2004
    ..epithelium compared to normal pancreatic ductal epithelium (>3-fold) including S100P, PSCA, c-myc, STK6/STK15, cathepsin E and pepsinogen C...
  76. ncbi Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice
    Tohru Sakai
    Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 59:95-101. 2012
    ..Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs...
  77. pmc Cathepsin e deficiency impairs autophagic proteolysis in macrophages
    Takayuki Tsukuba
    Division of Oral Pathopharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    PLoS ONE 8:e82415. 2013
    b>Cathepsin E is an endosomal aspartic proteinase that is predominantly expressed in immune-related cells...
  78. ncbi Age-related and dexamethasone-induced changes in cathepsins E and D in rat thymic and splenic cells
    K Nishishita
    Department of Pharmacology, Nagasaki University School of Dentistry, Japan
    Arch Biochem Biophys 333:349-58. 1996
    ..in the cellular levels, distributions, and molecular forms of two distinct intracellular aspartic proteinases, cathepsin E (CE) and cathepsin D (CD), were investigated in rat thymus and spleen by immunohistochemical and quantitative ..
  79. ncbi Cloning, expression and characterisation of murine procathepsin E
    P J Tatnell
    School of Molecular and Medical Biosciences, University of Wales, Cardiff, UK
    FEBS Lett 408:62-6. 1997
    ..The activity of the purified recombinant mouse cathepsin E was characterised quantitatively using two synthetic peptide substrates and naturally occurring inhibitors...
  80. ncbi Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools
    D Arnold
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Eur J Biochem 249:171-9. 1997
    ..library and a native protein as substrates, we confirm and extend the knowledge about the cleavage motif of cathepsin E where positions P1 and P1' of the substrate must be occupied exclusively by hydrophobic amino acids with ..
  81. ncbi Monomeric human cathepsin E
    S D Fowler
    School of Molecular and Medical Biosciences, University of Wales College of Cardiff, UK
    FEBS Lett 366:72-4. 1995
    b>Cathepsin E is a homodimer, consisting of two monomers linked by an inter-molecular disulphide bond. The cysteine residue involved is located near to the N-terminus of the mature proteinase...
  82. ncbi Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Ann Hum Genet 61:369-73. 1997
    ..and neuromedin N which are bioactive peptides derived from larger precursors via proteolytic cleavage by cathepsin E at processing sites determined by conserved C-terminal sequences, i.e...
  83. doi Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis
    Maria Caruso
    Gastroenterology Research Laboratory, Surgical Pathology, SA Pathology, Adelaide, 5000, Australia
    Virchows Arch 454:291-302. 2009
    ..Further studies using quantitative real-time polymerase chain reaction on cathepsin E (CTSE) demonstrated a significantly (p < 0...
  84. ncbi Evolutionary conserved cathepsin E substrate specificity as defined by N-terminal and C-terminal sequencing of peptide pools
    D Arnold
    Department of Immunology, Eberhard Karis University, Tubingen, Germany
    Biol Chem 378:883-91. 1997
    The substrate specificity of the non-lysosomal aspartic protease cathepsin E from three different species has been studied using the method of automated N-terminal sequencing and a newly developed method for C-terminal sequencing of ..
  85. ncbi Mannose-pepstatin conjugates as targeted inhibitors of antigen processing
    Paul Free
    University College London, Department of Chemistry, Christopher Ingold Laboratories, UK
    Org Biomol Chem 4:1817-30. 2006
    ..The mannose-pepstatin conjugates showed no reduction in inhibition of cathepsin E, whereas the neomannosylated BSA-pepstatin conjugates showed some loss of inhibition, probably due to steric ..
  86. doi Emerging roles of cathepsin E in host defense mechanisms
    Kenji Yamamoto
    Proteolysis Research Laboratory, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1824:105-12. 2012
    b>Cathepsin E is an intracellular aspartic proteinase of the pepsin superfamily, which is predominantly expressed in certain cell types, including the immune system cells and rapidly regenerating gastric mucosal and epidermal keratinocytes...
  87. pmc The plasticity of regulatory T cell function
    Meenu R Pillai
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 187:4987-97. 2011
    ..Loss of IL-10 and IL-35 was compensated for by a concurrent increase in cathepsin E (Ctse) expression, enhanced TRAIL (Tnfsf10) expression, and soluble TRAIL release, rendering IL-10/IL-35 double-..
  88. ncbi Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage
    T F Schulz
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    AIDS Res Hum Retroviruses 9:159-66. 1993
    ..the effect of several mutations in the V3 loop on its susceptibility to proteolytic cleavage by thrombin and cathepsin E and compared it with the effect of these mutations on viral infectivity...
  89. ncbi Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes
    M Takeda-Ezaki
    Department of Pharmacology, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Arch Biochem Biophys 304:352-8. 1993
    b>Cathepsin E (CE) is an intracellular, nonlysosomal aspartic proteinase which consists of two identical subunits with a molecular weight of about 42 kDa (K. Yamamoto, M. Takeda, H. Yamamoto, M. Tatsumi, and Y. Kato, 1985, J. Biochem...
  90. ncbi Subcellular localization and targeting of cathepsin E
    E M Finley
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 269:31259-66. 1994
    The subcellular distribution and targeting of the non-lysosomal aspartic proteinase cathepsin E have been studied using mouse L cells and monkey Cos 1 cells that were transfected with cDNA encoding cathepsin E...
  91. ncbi Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases
    T Azuma
    Department of Molecular Biology and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201
    J Biol Chem 264:16748-53. 1989
    The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line...
  92. ncbi Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids
    J M Couvreur
    Department of Molecular Biology and Genetics, School of Medicine, Detroit, MI
    Cytogenet Cell Genet 53:137-9. 1990
    A full length cathepsin E (CTSE) cDNA clone was used to assign the corresponding gene to human chromosome region 1q31 by in situ hybridization...
  93. ncbi Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E
    S B Athauda
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    Biochem Biophys Res Commun 168:878-85. 1990
    The amino acid sequences in the NH2-terminal region and some other parts of human gastric cathepsin E were investigated. The NH2-terminal sequencing revealed that the cathepsin E preparation which had been activated at pH 4...
  94. ncbi Structural studies of rat cathepsin E: amino-terminal structure and carbohydrate units of mature enzyme
    S Yonezawa
    Department of Zoology, Faculty of Science, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 166:1032-8. 1990
    The amino-terminal structure of rat gastric cathepsin E was identified and compared with the corresponding regions of human procathepsin E and other aspartic proteinases...
  95. ncbi Cathepsin E immunoreactivity in human ocular tissues: influence of aging and pathological states
    H G Bernstein
    Department of Psychiatry, Medical Faculty, Otto von Guericke University Magdeburg, Germany
    Neurosci Lett 240:135-8. 1998
    We studied the antigenic expression of the aspartic proteinase cathepsin E in normal and pathologic human ocular tissues obtained from donors of different age...
  96. ncbi Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D
    Francois Authier
    INSERM U510, Faculte de Pharmacie Paris XI, 92296 Chatenay Malabry, France
    J Biol Chem 277:9437-46. 2002
    ..immunoprecipitation and immunoblotting procedures, other endosomal aspartic acid proteases such as cathepsin E and beta-site amyloid precursor protein-cleaving enzyme (BACE) were ruled out as candidate enzymes for the ..
  97. ncbi Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis
    Holly E Marin
    Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cancer Res 66:4394-401. 2006
    ..in the expression of mRNA encoding adipocyte differentiation-related protein, fatty acid-binding protein, and cathepsin E. These findings are indicative of colonocyte differentiation, which was confirmed by immunohistochemical ..
  98. ncbi Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing
    Catherine X Moss
    Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee, UK
    Eur J Immunol 35:3442-51. 2005
    ..activity persists in lysosomes from cathepsin D-null DC and that this reduced activity, most likely due to cathepsin E, is closer to the optimum level required for myoglobin antigen presentation...
  99. ncbi Proteolytic processing by matrix metalloproteinases and phosphorylation by protein kinase CK2 of fetuin-A, the major globulin of fetal calf serum
    Dieter Kübler
    Mechanisms of Biomolecular Interactions A060, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochimie 89:410-8. 2007
    ..single-chain precursor by metalloproteinases MMP-3 (stromelysin-1) and MMP-7 (matrilysin), but not by elastase, cathepsin E and cathepsin G...
  100. ncbi A role for cathepsin E in the processing of mast-cell carboxypeptidase A
    Frida Henningsson
    Swedish University of Agricultural Sciences, Department of Molecular Biosciences, The Biomedical Centre, Box 575, 751 23 Uppsala, Sweden
    J Cell Sci 118:2035-42. 2005
    ..Here, we show that mast cells from mice lacking the aspartic protease cathepsin E display an accumulation of procarboxypeptidase A, indicating a defect in carboxypeptidase-A processing...
  101. ncbi Modeling the tertiary structure of human cathepsin-E
    Kuo Chen Chou
    Gordon Life Science Institute, 13784 Torrey Del Mar, San Diego, CA 92130, USA
    Biochem Biophys Res Commun 331:56-60. 2005
    ..The computed three-dimensional structure of cathepsin-E and the relevant findings might provide useful insights for designing inhibitors with the desired selectivity...

Research Grants57

  1. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  2. Role of the antiviral ribonuclease, RNase-L, in the host antibacterial response
    Bret A Hassel; Fiscal Year: 2010
    ..The proposed studies will provide the first information on the role of RNase-L as a novel mediator of antibacterial activity, and will evaluate the antibacterial activity of RNase-L activators as a new class of therapeutic agent. ..
  3. Role of the antiviral ribonuclease, RNase-L, in the host antibacterial response
    Bret A Hassel; Fiscal Year: 2010
    ..The proposed studies will provide the first information on the role of RNase-L as a novel mediator of antibacterial activity, and will evaluate the antibacterial activity of RNase-L activators as a new class of therapeutic agent. ..
  4. Role of the antiviral ribonuclease, RNase-L, in the host antibacterial response
    Bret Hassel; Fiscal Year: 2009
    ..The proposed studies will provide the first information on the role of RNase-L as a novel mediator of antibacterial activity, and will evaluate the antibacterial activity of RNase-L activators as a new class of therapeutic agent. ..
  5. MECHANISMS OF PEPSIN CATALYSIS AND INHIBITION
    Ben Dunn; Fiscal Year: 2001
    ..2. Comparison of the structure and properties of human cathepsin E with the other mammalian enzymes, pepsin and cathepsin D. 3...
  6. Nanoscale-Natural Products Chemistry
    TADEUSZ MOLINSKI; Fiscal Year: 2007
    ....
  7. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    TADEUSZ MOLINSKI; Fiscal Year: 2007
    ..Optimized leads identified from those libraries will be advanced to in vitro and in vivo trials. ..
  8. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    Tadeusz F Molinski; Fiscal Year: 2010
    ..Optimized leads identified from those libraries will be advanced to in vitro and in vivo trials. ..
  9. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    TADEUSZ MOLINSKI; Fiscal Year: 2004
    ....
  10. NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
    TADEUSZ MOLINSKI; Fiscal Year: 2001
    ..5. To understand how modulation of the FKBP12/ryanodine receptor complex by bastadins influences cellular growth and differentiation using the BC3H1 cell line as model. ..
  11. ANTIFUNGAL AGENTS FROM MARINE INVERTEBRATES
    TADEUSZ MOLINSKI; Fiscal Year: 1999
    ....
  12. Nanoscale-Natural Products Chemistry
    TADEUSZ MOLINSKI; Fiscal Year: 2009
    ....
  13. Natural Product Antitumor Inducers of Apoptosis
    TADEUSZ MOLINSKI; Fiscal Year: 2004
    ..abstract_text> ..
  14. Sound excitable drugs
    Ching Hsuan Tung; Fiscal Year: 2010
    ..The proposed sonochemotherapeutic technology is unique and could have great potential in cancer treatment. If successful, it could become a safe substitute to currently used radiation therapy. ..
  15. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2009
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  16. Dendritic nanomedicine for cancer imaging and treatment
    Ching Hsuan Tung; Fiscal Year: 2010
    ..The proposed nanomedicine could have vast translational potential and could be introduced into the clinic fairly rapidly following efficacy testing in animal models. ..
  17. Dendritic nanomedicine for cancer imaging and treatment
    Ching Hsuan Tung; Fiscal Year: 2009
    ..The proposed nanomedicine could have vast translational potential and could be introduced into the clinic fairly rapidly following efficacy testing in animal models. ..
  18. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  19. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2009
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  20. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  21. Dendritic nanomedicine for cancer imaging and treatment
    Ching Hsuan Tung; Fiscal Year: 2009
    ..The proposed nanomedicine could have vast translational potential and could be introduced into the clinic fairly rapidly following efficacy testing in animal models. ..
  22. Novel optical probes fir in vivo imaging
    Ching Hsuan Tung; Fiscal Year: 2006
    ..abstract_text> ..
  23. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian Lewis; Fiscal Year: 2007
    ....
  24. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. ..
  25. Imaging tumor associated fibroblast activation protein
    Ching Hsuan Tung; Fiscal Year: 2007
    ..We believe that the developed approach can be used as a platform to design a broad spectrum of activatable molecular probes to image other amino peptidases in vivo. ..
  26. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian Lewis; Fiscal Year: 2009
    ..abstract_text> ..