amylases

Summary

Summary: A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.

Top Publications

  1. pmc Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan Entamoeba histolytica
    Atsushi Furukawa
    Department of Parasitology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan
    Infect Immun 81:1820-9. 2013
  2. ncbi Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo
    K C Chao
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 10043, Taiwan
    Br J Surg 93:332-8. 2006
  3. pmc Mutants of Arabidopsis lacking a chloroplastic isoamylase accumulate phytoglycogen and an abnormal form of amylopectin
    Fabrice Wattebled
    Unite de Glycobiologie Structurale et Fonctionnelle, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Plant Physiol 138:184-95. 2005
  4. ncbi Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
    J Biol Chem 277:22595-604. 2002
  5. ncbi Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
    I Iontcheva
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Dent Res 76:734-43. 1997
  6. ncbi Etiology and outcome of acute pancreatitis in infants and toddlers
    Leena Kandula
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    J Pediatr 152:106-10, 110.e1. 2008
  7. ncbi Case report of acute necrotizing pancreatitis associated with combination treatment of sitagliptin and exenatide
    Shridhar N Iyer
    Department of Internal Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Endocr Pract 18:e10-3. 2012
  8. ncbi Responses of midgut amylases of Helicoverpa armigera to feeding on various host plants
    Hemlata M Kotkar
    Plant Molecular Biology Unit, National Chemical Laboratory, Division of Biochemical Sciences, M S, India
    J Insect Physiol 55:663-70. 2009
  9. pmc Biochemical markers of acute pancreatitis
    W R Matull
    Institute of Hepatology, University College London Medical School, London, UK
    J Clin Pathol 59:340-4. 2006
  10. pmc VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
    Laura I Cosen-Binker
    Department of Medicine, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Clin Invest 118:2535-51. 2008

Detail Information

Publications254 found, 100 shown here

  1. pmc Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan Entamoeba histolytica
    Atsushi Furukawa
    Department of Parasitology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan
    Infect Immun 81:1820-9. 2013
    ..Immunoblot and proteome analyses of the isolated phagosomes showed that CPBF6 mediates transport of amylases to phagosomes...
  2. ncbi Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo
    K C Chao
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 10043, Taiwan
    Br J Surg 93:332-8. 2006
    ..This study examined the effect of neutralizing antibody against IL-6 on the induction of pancreatic acinar cell apoptosis and attenuation of the severity of severe acute pancreatitis...
  3. pmc Mutants of Arabidopsis lacking a chloroplastic isoamylase accumulate phytoglycogen and an abnormal form of amylopectin
    Fabrice Wattebled
    Unite de Glycobiologie Structurale et Fonctionnelle, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Plant Physiol 138:184-95. 2005
    ..This suggests that the function of pullulanase partly overlaps that of Iso1, although its implication remains negligible when Iso1 is present within the cell...
  4. ncbi Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
    J Biol Chem 277:22595-604. 2002
    ..Protection against necrosis and trypsin activation by caspases can explain why the severity of pancreatitis in experimental models correlates inversely with the extent of apoptosis...
  5. ncbi Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
    I Iontcheva
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Dent Res 76:734-43. 1997
    ....
  6. ncbi Etiology and outcome of acute pancreatitis in infants and toddlers
    Leena Kandula
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    J Pediatr 152:106-10, 110.e1. 2008
    ..To determine the etiologic factors and outcome of acute pancreatitis in children under age 3 years...
  7. ncbi Case report of acute necrotizing pancreatitis associated with combination treatment of sitagliptin and exenatide
    Shridhar N Iyer
    Department of Internal Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Endocr Pract 18:e10-3. 2012
    ..To report the first postmarketing case of necrotizing pancreatitis in a patient on combination therapy of sitagliptin and exenatide...
  8. ncbi Responses of midgut amylases of Helicoverpa armigera to feeding on various host plants
    Hemlata M Kotkar
    Plant Molecular Biology Unit, National Chemical Laboratory, Division of Biochemical Sciences, M S, India
    J Insect Physiol 55:663-70. 2009
    Midgut digestive amylases and proteinases of Helicoverpa armigera, a polyphagous and devastating insect pest of economic importance have been studied. We also identified the potential of a sorghum amylase inhibitor against H...
  9. pmc Biochemical markers of acute pancreatitis
    W R Matull
    Institute of Hepatology, University College London Medical School, London, UK
    J Clin Pathol 59:340-4. 2006
    ..For obscure aetiologies, serum calcium and triglycerides should be measured. Genetic polymorphisms may play an important role in "idiopathic" acute recurrent pancreatitis...
  10. pmc VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
    Laura I Cosen-Binker
    Department of Medicine, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Clin Invest 118:2535-51. 2008
    ..These findings indicate that VAMP8 is the ZG-SNARE that mediates basolateral exocytosis in alcoholic pancreatitis and that VAMP8 is critical for ZG-ZG homotypic fusion...
  11. ncbi IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005
    ..Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth...
  12. ncbi Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis
    E Vaquero
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1197-208. 2001
    ..Correlation between localized NF-kappaB activation, cytokine upregulation, and tissue damage suggests a key role for NF-kappaB in the development of the inflammatory response of acute pancreatitis...
  13. ncbi Cell death in pancreatitis: caspases protect from necrotizing pancreatitis
    Olga A Mareninova
    Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90073, USA
    J Biol Chem 281:3370-81. 2006
    ..Manipulating these signals to change the pattern of death responses presents a therapeutic strategy for treatment of pancreatitis...
  14. ncbi Development of a new mouse model of acute pancreatitis induced by administration of L-arginine
    Rajinder Dawra
    Department of Surgery, University of Minnesota, MMC 195, 420 Delaware St SE, Minneapolis, MN 55416, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1009-18. 2007
    ..Our results indicate that administration of L-arginine to mice results in severe acute pancreatitis. This model should help in elucidating the pathophysiology of pancreatitis...
  15. pmc Low serum amylase in association with metabolic syndrome and diabetes: A community-based study
    Kei Nakajima
    Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama, 350 0295, Japan
    Cardiovasc Diabetol 10:34. 2011
    ..Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes...
  16. ncbi Understanding salivary fluid and protein secretion
    R James Turner
    Membrane Biology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda 20892 1190, USA
    Oral Dis 8:3-11. 2002
  17. ncbi Evaluation of a rapid urine amylase test using post-ERCP hyperamylasemia as a model
    M J Hegewald
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Ohio 44106, USA
    Am J Gastroenterol 96:2640-5. 2001
    ..The urine test strip was positive in all cases of clinical pancreatitis and may be a useful bedside test for the diagnosis of acute pancreatitis...
  18. ncbi Acute pancreatitis
    Simon J F Harper
    Department of Pancreaticobiliar Surgery, Luton and Dunstable NHS Foundation Trust, Lewsey Road, Luton, LU4 0DZ, UK
    Ann Clin Biochem 48:23-37. 2011
    ..The multidisciplinary approach to management of severe pancreatitis is outlined, including areas of controversy and novel treatments...
  19. ncbi Histopathologic correlates of serum amylase activity in acute experimental pancreatitis
    J Schmidt
    Department of Surgery, Massachusetts General Hospital, Boston 02114
    Dig Dis Sci 37:1426-33. 1992
    ..31). Inasmuch as edema and fat necrosis are not important determinants of severity, these observations could explain the poor prognostic value of serum amylase activity in patients with acute pancreatitis...
  20. ncbi Urinary trypsinogen-2 dipstick in acute pancreatitis
    Anders Møller Andersen
    Department of Surgery K, Bispebjerg Hospital, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Pancreas 39:26-30. 2010
    ..Urinary trypsinogen-2 has been suggested as a promising diagnostic marker; however, studies using the urinary trypsinogen-2 dipstick test (UTDT) have provided varying results...
  21. ncbi Genetic variation in mouse salivary amylase rate of synthesis
    J P Hjorth
    Biochem Genet 17:665-82. 1979
    ..Studies of other mouse strains suggest that regulatory genetic elements may modulate salivary amylase production...
  22. ncbi Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology
    Annamaria Szabolcs
    1st Department of Medicine, University of Szeged, Szeged, Hungary
    Pancreas 35:249-55. 2007
    ..Our experiments were designed to investigate the effects of zerumbone pretreatment on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis in rats...
  23. ncbi Serum amylase and risk of the metabolic syndrome in Korean adults
    Jeong Gyu Lee
    Department of Family Medicine, Pusan National University School of Medicine, Gyeongsangnam do, South Korea
    Clin Chim Acta 412:1848-53. 2011
    ..Serum amylase has recently been shown to be associated with ghrelin and adiponectin as well as obesity. We investigated the relationship between total amylase and metabolic syndrome in adults...
  24. pmc Cholinergic mediation of alcohol-induced experimental pancreatitis
    Aurelia Lugea
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
    Alcohol Clin Exp Res 34:1768-81. 2010
    ..For this study, we determined the role of the cholinergic system in ethanol-induced sensitizing effects on cerulein pancreatitis...
  25. pmc Zymogen activation in a reconstituted pancreatic acinar cell system
    Edwin C Thrower
    Veterans Administration Medical Center, Bldg 27, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 290:G894-902. 2006
    ..A component of the activation of some zymogens, such as chymotrypsinogen and procarboxypeptidase, may depend on ATP but not on trypsin or cathepsin B...
  26. pmc Rap1 activation plays a regulatory role in pancreatic amylase secretion
    Maria E Sabbatini
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    J Biol Chem 283:23884-94. 2008
    ..Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III...
  27. ncbi The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis
    Hirohiko Satoh
    Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 51:186-93. 2004
    ..The results suggest that continuous FOY-007 arterial infusion therapy is useful as a local treatment for severe acute pancreatitis...
  28. ncbi Expression of amylase and glucose oxidase in the hypopharyngeal gland with an age-dependent role change of the worker honeybee (Apis mellifera L.)
    K Ohashi
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Eur J Biochem 265:127-33. 1999
    ....
  29. ncbi Amylolytic activity of IgG and sIgA immunoglobulins from human milk
    T G Kanyshkova
    Biophysics Department, St. Petersburg Technical University, St. Petersburg, Russia
    Clin Chim Acta 314:141-52. 2001
    ..CONCLUSIONS: IgG antibodies, their Fab fragments, and sIgA fractions isolated from human milk of healthy women possessed amylolytic activity in the hydrolysis of maltooligosaccharides and several artificial substrates...
  30. ncbi The protective effects of Lipoxin A4 during the early phase of severe acute pancreatitis in rats
    Mengtao Zhou
    Department of Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
    Scand J Gastroenterol 46:211-9. 2011
    ..Our aim was to investigate the protective effects of a Lipoxin A(4) analogue (LXA4) in the early phase of acute pancreatitis in rats...
  31. ncbi Protective effects of baicalin and octreotide on multiple organ injury in severe acute pancreatitis
    Xi Ping Zhang
    Department of General Surgery, Hangzhou First People s Hospital, 261 Huansha Road, Hangzhou, Zhejiang Province 310006, China
    Dig Dis Sci 53:581-91. 2008
    ..To discuss the application value of Baicalin which is a new drug by comparing the protecting effects of Baicalin and Octreotide on multiple organs (pancreas, liver, kidney, and lung) in Severe acute pancreatitis (SAP)...
  32. pmc Therapeutic application of caspase 1/interleukin-1beta-converting enzyme inhibitor decreases the death rate in severe acute experimental pancreatitis
    Adam S Paszkowski
    Departments of General Surgery and Pathology, University of Ulm, Ulm, Germany
    Ann Surg 235:68-76. 2002
    ..To assess the effect of therapeutic inhibition of interleukin 1beta-converting enzyme (ICE) in an experimental model of severe acute pancreatitis (SAP)...
  33. ncbi Ghrelin inhibits the development of acute pancreatitis and nuclear factor kappaB activation in pancreas and liver
    Xiaolei Zhou
    Surgery of Integrated Traditional and Western Medicine Department, Tianjin Medical University General Hospital, China
    Pancreas 38:752-7. 2009
    ..To investigate the influence of ghrelin on the development of severe acute pancreatitis (SAP) and the expression of nuclear factor kappaB (NF-kappaB) p65 in the pancreas and liver...
  34. ncbi Origin and evolution of the Amyrel gene in the alpha-amylase multigene family of Diptera
    Frédérique Maczkowiak
    Populations, Genetique et Evolution, UPR 9034, CNRS, Gif sur Yvette, 91198, Cedex, France
    Genetica 128:145-58. 2006
    ..The putative encoded protein has about 40% divergence with the classical amylases. We have searched the presence of the paralog in other families of Diptera to track its origin and understand its ..
  35. ncbi Starch-binding domains in the post-genome era
    M Machovic
    Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 84551, Bratislava, Slovakia
    Cell Mol Life Sci 63:2710-24. 2006
    ..The family CBM20, known also as a classical C-terminal SBD of microbial amylases, is the most thoroughly studied...
  36. pmc Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell
    A Chaudhuri
    Gastrointestinal Research Laboratory, Veterans Affairs Healthcare Connecticut, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 288:G235-43. 2005
    ..This study demonstrates that increasing acinar cell cAMP can overcome the inhibition of enzyme secretion caused by high concentrations of carbachol and eliminate acinar cell injury...
  37. ncbi Control of the release of digestive enzymes in the larvae of the fall armyworm, Spodoptera frugiperda
    Digali Lwalaba
    Department of Animal Ecology I, University of Bayreuth, Bayreuth, Germany
    Arch Insect Biochem Physiol 73:14-29. 2010
    ....
  38. ncbi Infliximab: a new therapeutic agent in acute pancreatitis?
    Nevin Oruc
    Ege University, Faculty of Medicine, Gastroenterology Department, Izmir, Turkey
    Pancreas 28:e1-8. 2004
    ..The aim of this study is to investigate the therapeutic effectiveness of monoclonal TNF antibody (infliximab) in acute edematous and severe necrotizing pancreatitis models in rats...
  39. pmc Onset of cell-specific gene expression in the developing mouse pancreas
    G K Gittes
    Department of Surgery, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 89:1128-32. 1992
    ..Thus cell-specific gene expression in the endocrine pancreas begins in a "pre-morphogenetic phase." This early expression of insulin and glucagon could reflect the initiation of an endocrine cell lineage...
  40. ncbi Low serum amylase levels in drinking alcoholics
    Katsuya Maruyama
    Department of Internal Medicine, National Alcoholism Center, Kurihama Hospital, Yokosuka, Kanagawa, Japan
    Alcohol Clin Exp Res 27:16S-21S. 2003
    ..To elucidate the mechanism of this phenomenon, pancreatic isoamylase, salivary isoamylase, and amylase in urine were measured together with total serum amylase...
  41. ncbi Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography
    J Deviere
    Department of Gastroenterology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Gastroenterology 120:498-505. 2001
    ..Prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in humans is a unique model to study the potential role of IL-10 in this setting...
  42. ncbi Secretin-stimulated amylase release into blood is impaired in type 1 diabetes mellitus
    A Swislocki
    Section of Endocrinology, Medical Service, Veterans Affairs Medical Center, Martinez, California 94553, USA
    Horm Metab Res 37:326-30. 2005
    ....
  43. ncbi Biochemical analysis of serum pancreatic amylase and lipase enzymes in patients with type 1 and type 2 diabetes mellitus
    Adib A Aughsteen
    Faculty of Pharmacy, Al Zaytoonah University, PO Box 130, Amman 11733, Jordan
    Saudi Med J 26:73-7. 2005
    ..To examine the pancreatic exocrine insufficiency in patient with diabetes mellitus by estimating serum pancreatic amylase and lipase enzymes in healthy subjects and in type 1 and type 2 diabetic patients...
  44. ncbi Bacterial diversity and bioprospecting for cold-active lipases, amylases and proteases, from culturable bacteria of kongsfjorden and Ny-alesund, Svalbard, Arctic
    T N R Srinivas
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
    Curr Microbiol 59:537-47. 2009
    ..Fatty acid profile studies indicated that short chain fatty acids, unsaturated fatty acids, branched fatty acids, the cyclic and the cis fatty acids are predominant in the psychrophilic bacteria...
  45. ncbi Heterologous protein secretion by Lactobacillus plantarum using homologous signal peptides
    G Mathiesen
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    J Appl Microbiol 105:215-26. 2008
    ..plantarum, and to compare the functionality of these signal peptides with that of well-known heterologous signal peptides (Usp45, M6)...
  46. ncbi Time trends in incidence, etiology, and case fatality rate of the first attack of acute pancreatitis
    Thomas Omdal
    Medical Student Research Program, University of Bergen, Bergen, Norway
    Scand J Gastroenterol 46:1389-98. 2011
    ..The purpose of this study was to establish estimates of incidence and fatality rates, and to identify likely etiologies of first attack acute pancreatitis (FAAP) in an urban Norwegian population...
  47. pmc Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations
    Stefan Wildi
    Department of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gut 56:685-92. 2007
    ....
  48. ncbi A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells
    Cheng Chun Wang
    Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Dev Cell 7:359-71. 2004
    ..These results suggest a major physiological role of VAMP8 in regulated exocytosis of pancreatic acinar cells by serving as a v-SNARE of zymogen granules...
  49. ncbi Expression profile of amylolytic genes in Aspergillus nidulans
    Takashi Nakamura
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Biosci Biotechnol Biochem 70:2363-70. 2006
    ..Therefore, both CreA-dependent and -independent mechanisms are involved in the up-regulation of the amylolytic genes under carbon-starved conditions...
  50. ncbi Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis
    Laura I Cosen-Binker
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:1527-45. 2007
    ..This alcohol-induced susceptibility mechanism of pancreatitis is unknown...
  51. ncbi Use of mesophilic fungal amylases produced by solid-state fermentation in the cold hydrolysis of raw babassu cake starch
    Aline Machado de Castro
    Research and Development Center, Renewable Energy Division, PETROBRAS, Av Horácio Macedo, 950 Ilha do Fundão, Rio de Janeiro, Brazil
    Appl Biochem Biotechnol 162:1612-25. 2010
    b>Amylases constitute one of the most important groups of industrial enzymes, presenting several applications, such as in the food, textile, and ethanol manufacturing...
  52. ncbi Recombinant human interleukin-11 decreases severity of acute necrotizing pancreatitis in mice
    T Shimizu
    Department of Gastroenterology, Tokyo Women s Medical University, School of Medicine, Japan
    Pancreas 21:134-40. 2000
    ....
  53. ncbi Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea
    P Raghupathy
    Department of Child Health, Christian Medical College, Vellore, India
    J Pediatr Gastroenterol Nutr 42:362-8. 2006
    ....
  54. pmc Effect of BN52021 on NFkappa-Bp65 expression in pancreatic tissues of rats with severe acute pancreatitis
    Shi Hai Xia
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 13:882-8. 2007
    ..To investigate dynamic changes and significance of expression of NF-kappaBp65 in pancreatic tissues of rats with severe acute pancreatitis (SAP), as well as BN52021 effects...
  55. ncbi Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis
    Agnes S Kowalik
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G1123-32. 2007
    ....
  56. ncbi Laboratory diagnostic tests in acute pancreatitis
    Joseph Smotkin
    Division of Gastroenterology, Department of Medicine, Maimonides Medical Center, Brooklyn, New York 11219, USA
    J Clin Gastroenterol 34:459-62. 2002
    ..This review summarizes important aspects of standard laboratory tests and novel laboratory approaches in establishing the diagnosis, etiology, and severity of acute pancreatitis...
  57. ncbi Hyperbaric oxygen therapy attenuates pancreatic microcirculatory derangement and lung edema in an acute experimental pancreatitis model in rats
    H M Chen
    Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Pancreas 17:44-9. 1998
    ..Our results support the findings that HBO therapy has a beneficial effect on pancreatic microcirculation and lung edema during acute pancreatitis in rats...
  58. pmc Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats
    MADHAVI BHOOMAGOUD
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Gastroenterology 137:1083-92. 2009
    ..Clinical studies suggest that acidosis may affect the risk for developing pancreatitis. We hypothesized that exposure to an acid load might sensitize the acinar cell to secretagogue-induced pancreatitis...
  59. ncbi Characterization of alpha-maltotetraohydrolase produced by Pseudomonas sp. MS300 isolated from the deepest site of the mariana trench
    H Kobayashi
    Japan Marine Science and Technology Center, Deep sea Microorganism Research Group, Yokosuka, Japan
    Extremophiles 2:401-7. 1998
    ..The strain MS300 produced two major and two minor alpha-maltotetraohydrolases (G4-amylase). The two major G4-amylases share the same molecular weight of 55,000 but had different pI values, 5.0 and 4.7, respectively...
  60. ncbi The islet-acinar axis of the pancreas: more than just insulin
    Savio G Barreto
    Department of General and Digestive Surgery, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia 5042
    Am J Physiol Gastrointest Liver Physiol 299:G10-22. 2010
    ....
  61. pmc Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
    Abrahim I Orabi
    Department of Pediatrics, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 299:G196-204. 2010
    ..Blockade of Ca(2+) signals and particularly RYR-Ca(2+) may be useful as prophylactic treatment for this disease in high-risk settings for pancreatitis...
  62. pmc Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice
    Savio G Barreto
    Department of General and Digestive Surgery, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia
    HPB (Oxford) 12:403-11. 2010
    ..This study set out to compare the efficacy of a combined treatment of galantide and octreotide with the efficacy of each agent individually in experimental AP...
  63. pmc Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells
    Anouchka Skoudy
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    Biochem J 379:749-56. 2004
    ....
  64. ncbi Selective exocytosis of zymogen granules induces non-parallel secretion in short-term cholecystokinin-stimulated rats
    I De Dios
    Department of Physiology, University of Salamanca, 37007 Salamanca, Spain
    J Endocrinol 163:199-206. 1999
    ..We conclude that short-term CCK stimulation induces the selective release of large granules containing a high proportion of trypsinogen, which leads to a non-parallelism of enzyme secretion...
  65. ncbi Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas
    J S Nachnani
    Division of Gastroenterology and Hepatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Diabetologia 53:153-9. 2010
    ..Previous studies have evaluated the effect of exendin-4 on beta cells and beta cell function. We evaluated the histological and biochemical effects of exendin-4 on the pancreas in rats...
  66. ncbi Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans
    B W Wolf
    Ross Products Division, Abbott Laboratories, Columbus, OH 43215 1724, USA
    Eur J Clin Nutr 57:1120-7. 2003
    ....
  67. ncbi Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice
    Domenica Altavilla
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Lab Invest 83:1723-32. 2003
    ..Our data suggest that KO mice have an attenuated cerulein-induced pancreatitis and help to define the possible interaction between NF-kappaB activation and oxidative stress in this deleterious event...
  68. ncbi Compartmentalization of proteinases and amylases in Nauphoeta cinerea midgut
    E N Elpidina
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Arch Insect Biochem Physiol 48:206-16. 2001
    Compartmentalization of proteinases, amylases, and pH in the midgut of Nauphoeta cinerea Oliv. (Blattoptera:Blaberidae) was studied in order to understand the organization of protein and starch digestion...
  69. ncbi Purification of alpha-amylases using magnetic alginate beads
    S Teotia
    Chemistry Department, Indian Institute of Technology, Delhi, Hauz Khas
    Appl Biochem Biotechnol 90:211-20. 2001
    Magnetic alginate beads were used to purify alpha-amylases from porcine pancreas, starchzyme, BAN 240L (a commercial purification from Bacillus subtilis), and wheat germ...
  70. ncbi Lipid peroxidation inhibition reduces NF-kappaB activation and attenuates cerulein-induced pancreatitis
    Domenica Altavilla
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina Azienda Ospedaliera Universitario G Martino, Tore Biologica 5th Floor, Via Consolare Valeria, Gazzi, 98100 Messina, Italy
    Free Radic Res 37:425-35. 2003
    ..Indeed, lipid peroxidation inhibition might be considered a potential therapeutic approach to prevent the severe damage in acute pancreatitis...
  71. ncbi Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis
    Yen Ting Chen
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Pancreas 30:243-7. 2005
    ..This prospective study was designed to evaluate the diagnostic value and time course of the rapid urinary trypsinogen-2 test strip in acute pancreatitis, with comparisons with serum amylase and serum lipase...
  72. ncbi Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis
    I Simsek
    Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey
    Pancreas 23:296-301. 2001
    ..S-methylisothiourea (SMT) is an inducible nitric oxide synthase inhibitor that has been shown to decrease bacteria] translocation in sepsis and thermal injury...
  73. ncbi Early bacterial infection of the pancreas and course of disease in cerulein-induced acute pancreatitis in rats
    G Manes
    Department of Gastroenterology, Otto von Guericke University Magdeburg, Germany
    Dig Liver Dis 38:423-8. 2006
    ..Since bacterial translocation from the gut is likely to be an early event, in an animal model of pancreatitis, we investigated the effect of early bacterial supra-infection of the pancreas on the course of the disease...
  74. ncbi Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury
    Tetsuya Yamagiwa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 39:41-9. 2004
    ..The aim of this study was to examine the effects of inosine on the course of acute pancreatitis...
  75. pmc Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis?
    Yeon Soo Kim
    Department of Internal Medicine, Daejeon St Mary s Hospital Medical College of the Catholic University of Korea, Korea
    World J Gastroenterol 14:2401-5. 2008
    ..To investigate the correlation between the changes of pancreatic enzyme, the biochemical markers and the clinical results according to the Balthazar computer tomography (CT) grade...
  76. ncbi [Acute experimental pancreatitis in the opossum. The role of early splenectomy in the inflammatory response]]
    H A Garcia
    Secciòn Cirugìa Experimental, Servicio de Cirugìa General Hospital Churruca Visca
    Acta Gastroenterol Latinoam 32:71-7. 2002
    ..Acute pancreatitis (AP) does not escape this disconcert. In fact, like in every severe acute inflammatory process, its discontrol could be responsible of the high morbidity and mortality rates...
  77. ncbi Should serum pancreatic lipase replace serum amylase as a biomarker of acute pancreatitis?
    Ross C Smith
    Sydney University Department of Surgery, Royal North Shore Hospital, Sydney New South Wales, Australia
    ANZ J Surg 75:399-404. 2005
    ..Serum pancreatic lipase may improve the diagnosis of pancreatitis compared to serum amylase. Both enzymes have been measured simultaneously at our hospital allowing for a comparison of their diagnostic accuracy...
  78. ncbi Stimulation of sensory nerves and CGRP attenuate pancreatic damage in ischemia/reperfusion induced pancreatitis
    Artur Dembinski
    Department of Physiology, Jagiellonian University Medical School, Cracow, Poland
    Med Sci Monit 9:BR418-25. 2003
    ..The aim of this study was to examine the role of capsaicin-sensitive nerves and the impact of CGRP administration on necrotizing pancreatitis induced by ischemia/reperfusion...
  79. ncbi Factors contributing to infectious diarrhea-associated pancreatic enzyme alterations
    Jean Marie Reimund
    Service d Hépato Gastroentérologie et d Assistance Nutritive, Hopitaux Universitaires de Strasbourg, Hopital de Hautepierre, Avenue Moliere, 67098 Strasbourg Cedex
    Gastroenterol Clin Biol 29:247-53. 2005
    ..We studied 59 patients presenting acute infectious diarrhea in order to determine the incidence as well as to identify factors which may contribute to the occurrence of pancreatic enzyme alteration or true acute pancreatitis...
  80. ncbi Systemic lupus erythematosus-related acute pancreatitis: a case report
    Hueng Chuen Fan
    Department of Pediatrics, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 36:212-4. 2003
    ..9 mg/dL; C4, 2.3 mg/dL) during the pancreatitis attack suggested that the pancreatitis may have been due to systemic lupus erythematosus exacerbation and not related to drug therapy...
  81. ncbi p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I
    Sophie Vasseur
    Centre de Recherche INSERM, EMI 0116, 163 Avenue de Luminy, BP172, 13009 Marseille, France
    J Biol Chem 279:7199-207. 2004
    ..In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I...
  82. ncbi Reduction of ischemia/reperfusion injury by antithrombin III after experimental pancreas transplantation
    Thilo Hackert
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Am J Surg 189:92-7. 2005
    ..Antithrombin III (AT III) is an anticoagulatory and anti-inflammatory substance. The aim of our study was to evaluate a prophylactic application of AT III in experimental pancreas transplantation...
  83. ncbi Quantification of pancreatic zinc output as pancreatic function test: making the secretin-caerulein test applicable to clinical practice
    J Enrique Domínguez-Muñoz
    Department of Gastroenterology, University Hospital, Santiago de Compostela, Spain
    Pancreatology 4:57-62. 2004
    ..The aim of this study was to analyze the accuracy of the secretin-caerulein-stimulated pancreatic zinc output as pancreatic function test in comparison with the standard SCT...
  84. ncbi The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis
    Adem Karatas
    Department of General Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Surg Res 148:7-12. 2008
    ..The aim of this paper is to assess the effects of halofuginone, a specific inhibitor of synthesis of collagen Type 1, on fibrogenetic process in an experimental model of early pancreatic fibrosis...
  85. ncbi Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity
    Yusuke Sugiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii cho, Kamigyo, Kyoto, 802 8566, Japan
    Inflammopharmacology 13:291-301. 2005
    ..It is assumed that endogenous NO may be involved in oedema formation as the early event in the development of acute pancreatitis...
  86. ncbi Aqueous extract of black tea (Camellia sinensis) prevents ethanol+cholecystokinin-induced pancreatitis in a rat model
    Dolan Das
    Department of Physiology, Presidency College, Calcutta, India
    Life Sci 78:2194-203. 2006
    ..These findings suggest that BTE prevents pancreatitis caused by chronic EtOH+CCK toxicity presumably by enhancing antioxidant, anti-inflammatory and antiapoptotic activity in rats...
  87. ncbi Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis
    Letteria Minutoli
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina AOU G Martino Torre Biologica 5th floor, Via Consolare Valeria, Gazzi 98100, Messina, Italy
    Life Sci 75:2853-66. 2004
    ....
  88. ncbi Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery
    Z Warzecha
    Department of Physiology, Jagiellonian University School of Medicine, Cracow, Poland
    J Physiol Pharmacol 52:679-704. 2001
    ..After induction of AP, persistent activity of sensory nerves and presence of CGRP aggravate pancreatic damage and lead to functional insufficiency typical for chronic pancreatitis...
  89. ncbi Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis
    Srinivasan Balachandra
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, England
    Surgery 138:913-23. 2005
    ..The effects of the tyrosine kinase inhibitors, tyrphostin AG126 and AG556 in a murine model of acute pancreatitis are investigated...
  90. ncbi Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis
    Taketoshi Ogawa
    Pharmacology and Molecular Biology Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Tokyo 140 8710, Japan
    Eur J Pharmacol 521:156-63. 2005
    ..These results clearly indicate that R-102444 and R-96544 inhibit the progression of acute and chronic pancreatitis and support the contention of possible involvement of 5-HT2A receptors in the progression of experimental pancreatitis...
  91. ncbi The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat
    Jolanta Jaworek
    Department of Medical Physiology, Faculty of Health Care, Medical Faculty, Jagiellonian University CM, 31 531 Krakow, Poland
    J Pineal Res 37:161-70. 2004
    ....
  92. pmc Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis
    Hong Kai Gao
    Department of General Surgery, Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:661-4. 2005
    ....
  93. ncbi Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats
    Andrew A Young
    Amylin Pharmaceuticals Inc, 9360 Towne Centre Drive, San Diego, CA 92121, USA
    Regul Pept 130:19-26. 2005
    ..The neuroendocrine hormone amylin, cosecreted with insulin from pancreatic beta-cells in response to nutrient ingestion, has several physiologic actions to limit the rate of nutrient uptake, including the slowing of gastric emptying...
  94. ncbi Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas
    Francisco C Muñoz-Casares
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Pineal Res 40:195-203. 2006
    ..Preventive or therapeutic administration of melatonin protected against the induction of oxidative stress and tissue injury, and restored cell function in experimental pancreatic IR in rats...
  95. ncbi Beneficial effect of resveratrol on cholecystokinin-induced experimental pancreatitis
    Annamaria Szabolcs
    First Department of Medicine, University of Szeged, Faculty of Medicine, H 6720 Szeged, Koranyi fasor 8, Hungary
    Eur J Pharmacol 532:187-93. 2006
    ..In conclusion, the beneficial effects of resveratrol on acute pancreatitis seem to be mediated by the antioxidant effect of resveratrol or by an NF-kappaB-independent anti-inflammatory mechanism...
  96. ncbi Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action
    A Leja-Szpak
    Department Med Physiology Faculty of Health Care, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 55:239-54. 2004
    ..The beneficial effect of centrally administered L-tryptophan could be mediated through activation of central receptors for locally produced melatonin...
  97. ncbi Effects of bee venom on cholecystokinin octapeptide-induced acute pancreatitis in rats
    Sang Wan Seo
    Department of Herbology, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570 749, South Korea
    Pancreas 36:e22-9. 2008
    ..Bee venom (BV) has frequently been used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of BV on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis (AP) in rats...
  98. pmc Inhibitory effect of Patrinia scabiosaefolia on acute pancreatitis
    Sang Wan Seo
    Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570 749, South Korea
    World J Gastroenterol 12:1110-4. 2006
    ..To investigate the effect of Patrinia scabiosaefolia (PS) on the cholecystokinin (CCK) octapeptide-induced acute pancreatitis (AP) in rats...
  99. ncbi Management of gallstone pancreatitis
    Shawn D Larson
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0536, USA
    Adv Surg 40:265-84. 2006
    ..The management of these patients requires close clinical observation and a multidisciplinary approach between the surgeon, radiologist, gastroenterologist, and intensivist...
  100. ncbi Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Cytokine 18:274-85. 2002
    ....
  101. ncbi Induction of heat shock proteins fails to produce protection against trypsin-induced acute pancreatitis in rats
    Z Rakonczay
    First Department of Medicine, University of Szeged, Hungary
    Clin Exp Med 2:89-97. 2002
    ..The findings suggest that the induction of HSP60 or HSP72 are not enough to protect rats against the early phase of this localized necrohemorrhagic pancreatitis model...

Research Grants62

  1. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..abstract_text> ..
  2. Prenatal stress and epigenetic programming of the HPA axis and autonomic balance
    Rosalind J Wright; Fiscal Year: 2013
    ..This study may begin to inform how this happens at the most basic level. ..
  3. Risk for Dysfunctional Romantic Relationships for Adults
    Deborah M Capaldi; Fiscal Year: 2013
    ....
  4. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ....
  5. From Child Maltreatment to Adolescent Substance Abuse: Risks, Protective Factors
    Penelope K Trickett; Fiscal Year: 2010
    ..abstract_text> ..
  6. Inter-Parental Conflict, Maternal Behavior, and Mother-Child Physiology
    LEAH CORINNE HIBEL; Fiscal Year: 2012
    ....
  7. Pupil Size and Circadian Salivary Variations in Autism Spectrum Disorder
    JOHN A COLOMBO; Fiscal Year: 2010
    ....
  8. Effects of tai chi chuan on psychobiological indicators of anxiety and sleep qual
    KAREN LEIGH CALDWELL; Fiscal Year: 2012
    ..Information about who responds to tai chi chuan will be valuable in formulating treatment recommendations for young adults with symptoms of anxiety and attendant poor sleep quality. ..
  9. Integrative Pathways to Health and Illness: Testing Older Cohort Hypotheses
    Carol D Ryff; Fiscal Year: 2013
    ..The expanded MIDUS Refresher will lay the foundation for future tracking how economic hardship is changing the life course of different cohorts of American adults. ..
  10. A Novel Mitigation Agent for Gastrointestinal Syndrome of Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2009
    ..The results of these pre-clinical studies will provide the basis for eventual approval through the animal rule. A preliminary drug development plan has already been discussed with the FDA. ..
  11. Effects of pre- and postnatal IPV on infant behavior and physiology
    Alytia A Levendosky; Fiscal Year: 2010
    ..One hundred sixty women and their children will be assessed in a 4-group cohort design (those with and without IPV prenatally and postnatally). ..
  12. MicroRNAs and Parotid Acinar Cell Differentiation
    Melissa A Metzler; Fiscal Year: 2013
    ..abstract_text> ..
  13. A Novel Multiplexed Assay for Rapid Antibody Screening
    SCOTT ALLEN MONSMA; Fiscal Year: 2011
    ..The assays will be formatted in a high throughput, low-cost multiplexed platform that is supported by one touch user friendly software for data analysis and reporting. ..
  14. Regulation of Learning and Memory by Immediate Early Genes in Drosophila brain
    CRYSTAL GAYLE PONTRELLO; Fiscal Year: 2013
    ..Our results will also provide a greater understanding of normal learning and memory mechanisms, as well as potential therapeutic targets for neurological diseases that result in memory loss. ..
  15. Stress, Coping, Health, &Optimal Aging
    Carolyn M Aldwin; Fiscal Year: 2013
    ..The third specific aim will examine the impact of chronic stress, personality, gender, and aging on cortisol reactivity. ..
  16. Poverty, Stress, and Discounting: A potential micro-mechanism for behavior change
    Johannes Haushofer; Fiscal Year: 2013
    ..29 lines) ..
  17. Endocrine correlates of psychopathic traits in children: a multi-system approach
    ANDREA LORAINE GLENN; Fiscal Year: 2011
    ..By studying these traits in a relatively young age group, we may be able to intervene early, when this group of potentially chronic, severe offenders may be more amenable to intervention. ..
  18. Self-Regulation as a Biological Mechanism for Excess Weight Gain in Toddlers
    Alison L Miller; Fiscal Year: 2013
    ..The results could therefore be broadly applicable to more effective prevention of other unhealthy behaviors such as substance abuse. ..
  19. Sensitive and Specific Rapid Diagnostic Test for Acute and Chronic Pancreatitis
    SYAMAL X RAYCHAUDHURI; Fiscal Year: 2012
    ..The rapid point of care test will greatly enable the diagnostic evaluation of abdominal pain and pancreatitis in emergency rooms, urgent care clinics and primary care settings throughout the world. ..
  20. Caregiving, Attachment, and Regulation of Emotion (CARE)
    SUSAN SOLEDAD WOODHOUSE; Fiscal Year: 2013
    ....
  21. Optimizing 131I-mIBG Therapy for Children with Advanced Neuroblastoma
    Steven Dubois; Fiscal Year: 2013
    ..More generally, our work will inform other research focused on the use of radiation sensitizers and on development of novel biomarkers in patients receiving other forms of radiotherapy. ..
  22. Amylase binding and gene expression in S. gordonii
    FRANK ANDREW SCANNAPIECO; Fiscal Year: 2013
    ..This knowledge could well extend beyond biofilm development in the oral cavity, with application to other microbial communities affecting systemic disease. ..
  23. Biobehavioral Studies of Opioid Seeking Behavior
    Mark K Greenwald; Fiscal Year: 2013
    ....
  24. Promoting Well-Being Across Adulthood: The Role of Conflict Avoidance
    Kira S Birditt; Fiscal Year: 2012
    ..abstract_text> ..
  25. AMYLASE BINDING STREPTOCOCCI, DENTAL PLAQUE AND CARIES
    FRANK ANDREW SCANNAPIECO; Fiscal Year: 2011
    ..abstract_text> ..
  26. The Use of Fibrin Hydrogels to Build an Artificial Salivary Gland
    OLGA JULIANA BAKER; Fiscal Year: 2013
    ..These studies should lead to better therapeutic strategies to restore salivary gland dysfunction that contributes to xerostomia in patients with compromised salivary function. ..
  27. Refinement and Validation of a Portable, Salivary Biosensor of Psychosocial Stres
    Vivek Shetty; Fiscal Year: 2010
    ....
  28. The role of Pcif1 in pancreas development
    JEFFREY CHARLES RAUM; Fiscal Year: 2012
    ..Specifically, we will assess the role in acinar cell formation by quantifying cell numbers and the levels of proteins crucial for formation and function, including Ptf1a and amylase. ..
  29. Stress Reactivity as a Mechanism of Treatment Response in Pediatric OCD
    Tara S Peris; Fiscal Year: 2013
    ....
  30. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..These studies should render support for the association between inositol phospholipid breakdown mediated by PLC and PLA2, CA2+ metabolism, protein phosphorylation, and amylase secretion...
  31. Tramatic Stress After Pediatric Injury: Neurobiological Influences
    Linda Ewing-Cobbs; Fiscal Year: 2013
    ..Better understanding of the neurobiological mechanisms contributing to chronic morbidity following traumatic injuries is essential to design targeted interventions to reduce morbidity and enhance recovery. ..
  32. Integrating Biological Markers into Clinical Research
    GOLDA SUSAN GINSBURG; Fiscal Year: 2013
    ....
  33. LINGUAL SEROUS GLANDS--REGULATION OF ENZYME SECRETION
    RUTH FIELD; Fiscal Year: 1992
    ..When the complete mechanism of secretion is known, it will be possible to use this knowledge to treat pancreatic deficiency diseases by stimulating secretion of lingual lipase...
  34. NEW MUSCARINIC AGENTS--SELECTIVITY OF ACTION
    Frank Carroll; Fiscal Year: 1990
    ..The development of new, more effective, selective and less toxic cholinergic and anticholinergic drugs is of interest due to the possible therapeutic exploitation of the cholinergic hypothesis of Alzheimer's disease...
  35. A Novel Multiplexed Assay for Rapid Antibody Screening
    Bradley H Garcia; Fiscal Year: 2013
    ....
  36. MECHANISM OF DIETARY ADAPTATION OF PANCREATIC FUNCTION
    PATSY BRANNON; Fiscal Year: 1990
    ..Once the cellular mechanisms of adaptation are known the development of these regulatory mechanisms and the effects of perinatal nutrition on this development will be studied...
  37. IN VIVO STUDIES OF SALIVA ANTIMICROBIAL PROTEINS
    JOEL RUDNEY; Fiscal Year: 2001
    ..By focusing on redundancy and complexing, this project also addresses the question of whether individual proteins exert unique and specific effects in the mouth. ..
  38. XEROSTOMIA-INDUCING MECHANISMS OF PSYCHOTROPIC DRUGS
    JIA HUEY YU; Fiscal Year: 1993
    ..It would also provide information regarding the beneficial effect of a pharmacologic agent, Sialor, in antagonizing drug-induced changes in salivary gland function...
  39. GASTROINTESTINAL & CARDIAC RESPONSE TO SEMI-STARVATION
    Eleanor Young; Fiscal Year: 1991
    ....
  40. SECOND MESSENGER FUNCTION IN EXOCRINE GLANDS
    Thomas Hurley; Fiscal Year: 1993
    ..In addition these studies will be important in defining the factors that regulate normal salivary gland function and therefore are important for the maintenance of healthy soft and mineralized tissue in the oral cavity...
  41. PROTEIN KINASE C MEDIATION OF EXOCRINE PANCREATIC SECRET
    Dexter Louie; Fiscal Year: 1992
    ..These studies should increase our understanding of intracellular stimulus-secretion coupling events which regulate the initial, sustained and postmaximal phases of pancreatic secretion...
  42. SALIVARY GLANDS AND THEIR INNERVATION IN DIABETES
    JACOB HANKER; Fiscal Year: 1980
    ..The caries, plaque accumulation periodontal changes and changes observed in the tongue of the diabetic mice suggest that this mouse model may be of value in studying the oral effects of the disease...
  43. GENETIC ANALYSIS OF CHARCOT-MARIE-TOOTH DISEASE
    PHILLIP CHANCE; Fiscal Year: 1992
    ..A regional gene linkage map of chromosome 1 is of general scientific interest and will provide a useful tool to study many human disorders in this region...
  44. REGULATION OF GENE EXPRESSION BY INSULIN-MIMETIC AGENTS
    Susan Stapleton; Fiscal Year: 1992
    ....
  45. RESISTANT STARCH: ADJUNCT TO ORAL REHYDRATION SOLUTION
    HENRY BINDER; Fiscal Year: 2000
    ..Treatment failures will be categorized and recorded. If resistant starch is found to reduce fecal volumes and/or duration of diarrhea, this innovative therapy must then be tested in the community for acceptance. ..
  46. IMMORTALIZATION OF SALIVARY GLAND EPITHELIAL CELL LINES
    JANICE MORAND; Fiscal Year: 1993
    ..These possibilities will be investigated using nuclear runoff transcription and RNA stability assays...
  47. IMMORTALIZATION OF HUMAN SALIVARY EPITHELIAL CELL LINESS
    Dharam Chopra; Fiscal Year: 1992
    ..The availability of well characterized human salivary gland epithelial cell lines to the research community would facilitate studies on the molecular mechanisms that regulate secretions of the various cell types...
  48. Race socialization, interracial contact, and students' stress and development
    Sophie Trawalter; Fiscal Year: 2009
    ..Relevance to public health: taken as a whole, these studies will shed light on the development of college students'well-being and preparedness for life in a multicultural society. ..
  49. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2004
    ..The results are also expected to form a scientific basis for the design of disease-specific diets for patients with acute pancreatic disease. ..
  50. Promoting Well-Being Across Adulthood: The Role of Conflict Avoidance
    Kira Birditt; Fiscal Year: 2009
    ..Thus, identifying the most beneficial coping strategies will help to improve the health and well-being of adults as they age. ..
  51. PANCREATIC PRESERVATION FOR CLINICAL TRANSPLANTATION
    FOLKERT BELZER; Fiscal Year: 1991
    ..The solutions developed will be tested in clinical pancreas preservation and transplantation...
  52. Salivary Amylase: Role in Dental Caries Pathogenesis
    Narayanan Ramasubbu; Fiscal Year: 2007
    ..Finally, we are excited that our approach in dissecting the contribution of amylase to foster the colonization of S. mutans may serve as a model to study the role of other salivary proteins in the oral cavity. ..
  53. PROTEIN DRUG DELIVERY BASED ON STABILIZED PROTEIN
    ALEXEY MARGOLIN; Fiscal Year: 2000
    ..The worldwide market is currently $400 million with a $200 million portion being derived from US sales. ..
  54. NOVEL PROTEASE FORMULATION BASED ON CROSSLINKED CRYSTALS
    Bhami Shenoy; Fiscal Year: 2004
    ..TheraCLEC-Protease will be ready to enter clinical trials, and will provide a novel treatment for pancreatic insufficiency in chronic pancreatitis and cystic fibrosis along with TheraCLECLipase. ..
  55. RAT PAROTID EXOCYTOSIS
    David Quissell; Fiscal Year: 1992
    ..The studies should provide important new scientific information regarding the regulation of exocytosis...
  56. Oral Infectious Disease: Virulence and Host Determinants
    DAVID CULP; Fiscal Year: 2009
    ..Future studies can then focus on molecular mechanisms of host-pathogen interactions. Results may indicate important therapeutic targets to treat patients at high risk for caries (i.e., patients with xerostomia). ..
  57. GENE VARIATION IN NATURAL POPULATIONS
    Satya Prakash; Fiscal Year: 1980
    ..We will also study the activity variation of the AP-3 allozymes similarly. Genetic analyses will be performed with any newly discoverd variants...
  58. PANCREATIC CONTROL BY HISTAMINE
    Charles Liebow; Fiscal Year: 1980
    ....
  59. SALIVARY AMYLASE EXPRESSION IN PAROTID CELL LINES
    LINDA SAMUELSON; Fiscal Year: 1992
    ..The differentiated acinar cell lines developed in these studies will be a valuable resource for investigators studying the regulation of salivary cell function...
  60. GENETIC ANALYSIS OF BACILLUS SUBTILIS AMYLASE SYNTHESIS
    GLENN CHAMBLISS; Fiscal Year: 1992
    ..Elucidation of the mechanism of amylase regulation resulting from these experiments will provide insights into the regulatory mechanisms governing the expression of other postexponentially-expressed genes in B. subtilis...
  61. PHOSPHOPROTEINS AND SECRETION IN PORCINE PAROTID CELLS
    JACK BROOKS; Fiscal Year: 1992
    ..The investigators expect this proposed work to determine if phosphorylation of cell proteins plays a role in excitation-secretion coupling in parotid amylase secretion...
  62. Mood and Reactivity in Borderline Personality Disorder
    Lori Scott; Fiscal Year: 2009
    ..Understanding the physiological and psychological processes underlying these problematic features of BPD is imperative to the development of treatments aimed at reducing the burden of mental illness. ..