acetylcholinesterase

Summary

Summary: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Top Publications

  1. ncbi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
  2. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
  3. ncbi Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
    Heidi Q Xie
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
    J Biol Chem 285:11537-46. 2010
  4. ncbi Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase
    K Tai
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 81:715-24. 2001
  5. ncbi Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
    Z Argov
    Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
    Neurology 69:699-700. 2007
  6. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
  7. ncbi Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase
    R N'Guessan
    Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
    Med Vet Entomol 17:19-25. 2003
  8. ncbi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Biol Pharm Bull 32:1433-8. 2009
  9. ncbi Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
    M F Frasco
    IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
    Biomarkers 10:360-75. 2005
  10. ncbi Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008

Research Grants

  1. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2007
  2. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy Lahiri; Fiscal Year: 2009
  3. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
  4. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 1993
  5. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
  6. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
  7. Use of an Organophosphorus (OP) Hydrolase for Acute OP Poisoning
    Steven Bird; Fiscal Year: 2007
  8. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2010
  9. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
  10. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007

Detail Information

Publications271 found, 100 shown here

  1. ncbi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
    ..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
  2. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
    ..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
  3. ncbi Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
    Heidi Q Xie
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
    J Biol Chem 285:11537-46. 2010
    In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor)...
  4. ncbi Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase
    K Tai
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 81:715-24. 2001
    A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with special attention paid to the fluctuation in the width of the gorge and opening events of the back door...
  5. ncbi Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
    Z Argov
    Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
    Neurology 69:699-700. 2007
  6. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  7. ncbi Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase
    R N'Guessan
    Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
    Med Vet Entomol 17:19-25. 2003
    ..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
  8. ncbi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Biol Pharm Bull 32:1433-8. 2009
    ..Coptidis Rhizoma were evaluated via beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) assays, along with peroxynitrite (ONOO(-)) scavenging and total ..
  9. ncbi Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
    M F Frasco
    IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
    Biomarkers 10:360-75. 2005
    The enzymatic activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
  10. ncbi Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008
    ....
  11. ncbi Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
  12. ncbi Induction of acetylcholinesterase expression during apoptosis in various cell types
    X J Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell Death Differ 9:790-800. 2002
    b>Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission...
  13. ncbi Differential localization of acetylcholinesterase in neuronal and non-neuronal cells
    Matthew D Thullbery
    Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    J Cell Biochem 96:599-610. 2005
    b>Acetylcholinesterase (AChE) expression is regulated in cell types at the transcriptional and translational levels...
  14. ncbi ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities
    D Grisaru
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Mol Med 7:93-105. 2001
    ..Here we report the involvement of the stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, and its 26 amino acid C-terminal domain (ARP) in hematopoietic stress responses...
  15. ncbi Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase
    Dong Liang
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    J Biol Chem 284:5195-207. 2009
    The mammalian protein CutA was first discovered in a search for the membrane anchor of mammalian brain acetylcholinesterase (AChE). It was co-purified with AChE, but it is distinct from the real transmembrane anchor protein, PRiMA...
  16. ncbi Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
    Marco Giorgetti
    Medivation, Inc, San Francisco, California 94105, USA
    J Pharmacol Exp Ther 333:748-57. 2010
    ..Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and the N-methyl-d-aspartate (NMDA) receptor, the low in vitro affinity for these targets suggests ..
  17. ncbi A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation
    G V De Ferrari
    Center for Cell Regulation and Pathology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic University of Chile and Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
    Biochemistry 40:10447-57. 2001
    b>Acetylcholinesterase (AChE) has been found to be associated with the core of senile plaques...
  18. ncbi Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata
    Pradeep Kumar
    Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India
    Phytother Res 23:172-7. 2009
    ..Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata...
  19. ncbi High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
    K Ingkaninan
    Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
    J Chromatogr A 872:61-73. 2000
    ..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
  20. ncbi Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
    Martina Zimmermann
    Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 90:1489-99. 2004
    b>Acetylcholinesterase inhibitors (AChEIs) are the only currently available drugs for treating Alzheimer's Disease (AD)...
  21. ncbi Structural insights into substrate traffic and inhibition in acetylcholinesterase
    Jacques-Philippe Colletier
    , Institut de Biologie Structurale (CEA/CNRS/UJF, Grenoble Cedex, France
    EMBO J 25:2746-56. 2006
    b>Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine...
  22. ncbi Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds
    Pelayo Camps
    Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Med Chem 52:5365-79. 2009
    Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) ..
  23. ncbi N-acetylcholinesterase-induced apoptosis in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 3:e3108. 2008
    ..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.
  24. ncbi Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology
    Amit Berson
    The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Brain 131:109-19. 2008
    ..One known link involves synaptic acetylcholinesterase (AChE-S), shown to accelerate amyloid fibrils formation...
  25. ncbi Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology
    Israel Silman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Pharmacol 5:293-302. 2005
    The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine...
  26. ncbi Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005
    ..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
  27. ncbi Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    H Shimada
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
    Neurology 73:273-8. 2009
    ..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
  28. ncbi Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability
    Gerald B Downes
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 270:232-45. 2004
    The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine...
  29. ncbi A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress
    Rinat Kehat
    Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
    Invest Ophthalmol Vis Sci 48:1290-7. 2007
    To study the involvement of stress-induced acetylcholinesterase (AChE) expression in light-induced retinal damage in albino rats.
  30. ncbi Acetylcholinesterase in cell adhesion, neurite growth and network formation
    Laura E Paraoanu
    Darmstadt University of Technology, Germany
    FEBS J 275:618-24. 2008
    The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative ..
  31. ncbi Accumulation of nodularin-like compounds from the cyanobacterium Nodularia spumigena and changes in acetylcholinesterase activity in the clam Macoma balthica during short-term laboratory exposure
    Kari K Lehtonen
    Finnish Institute of Marine Research, PO Box 33, FIN 00931 Helsinki, Finland
    Aquat Toxicol 64:461-76. 2003
    ..b>Acetylcholinesterase (AChE) activity was measured from the foot tissue samples taken at 0, 24 and 96 h...
  32. ncbi Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system
    Marko Zivin
    University of Ljubljana, School of Medicine, Institute of Pathophysiology, Brain Research Laboratory, 1000 Ljubljana, Slovenia
    Psychiatr Danub 20:168-73. 2008
    b>Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles...
  33. ncbi Acetylcholinesterase inhibition in the threeridge mussel (Amblema plicata) by chlorpyrifos: implications for biomonitoring
    W J Doran
    River Studies Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin 54601, USA
    Ecotoxicol Environ Saf 49:91-8. 2001
    ..chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test...
  34. ncbi Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
    G V De Ferrari
    Department of Pharmacology and Program in Neurosciences, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    J Biol Chem 276:23282-7. 2001
    Three-dimensional structures of acetylcholinesterase (AChE) reveal a narrow and deep active site gorge with two sites of ligand binding, an acylation site at the base of the gorge, and a peripheral site near the gorge entrance...
  35. ncbi Layer-by-Layer self-assembled acetylcholinesterase/PAMAM-Au on CNTs modified electrode for sensing pesticides
    Yunhe Qu
    Department of Chemistry, East China Normal University, Shanghai, PR China
    Bioelectrochemistry 77:139-44. 2010
    In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples...
  36. ncbi Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway
    Nibaldo C Inestrosa
    FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Curr Alzheimer Res 2:301-6. 2005
    ..The only treatment for AD has been the use of inhibitors of acetylcholinesterase (AChE) (E.C. 3.1.1.7), which is one of the several proteins associated with amyloid plaque deposits...
  37. ncbi Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 224:91-9. 2006
    ..OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with ..
  38. ncbi Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine
    Lygia Azevedo Marques
    VU University Amsterdam, Faculty of Sciences, Section of Biomolecular Analysis, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Pharm Biomed Anal 53:609-16. 2010
    ..for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE)...
  39. ncbi Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
    W Xie
    Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805, USA
    J Pharmacol Exp Ther 293:896-902. 2000
    b>Acetylcholinesterase (AChE; EC 3.1.1.7) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development...
  40. ncbi Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Krøyer)
    Anders Fallang
    The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Pest Manag Sci 60:1163-70. 2004
    b>Acetylcholinesterase (AChE) is the target of a major pesticide family, the organophosphates, which were extensively used as control agents of sea lice on farmed salmonids in the early 1990s...
  41. ncbi Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'Ivoire
    Ludovic P Ahoua Alou
    Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
    Malar J 9:167. 2010
    ..It is, therefore, essential to investigate on the susceptibility of pyrethroid resistant populations of An. gambiae s.s. to these alternative products...
  42. ncbi Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Toxicology 233:60-9. 2007
    Butyrylcholinesterase (EC 3.1.1.8 BChE) is present in all human and mouse tissues, and is more abundant than acetylcholinesterase (EC 3.1.1.7 AChE) in all tissues except brain...
  43. ncbi Acetylcholine synthesis and possible functions during sea urchin development
    C Angelini
    Department of Experimental, Environmental and Applied Biology, University of Genoa, Genoa, Italy
    Eur J Histochem 48:235-43. 2004
    ..b>Acetylcholinesterase (AChE, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; ..
  44. ncbi Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration
    Katarina Pegan
    Laboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 187:96-100. 2010
    The best established role of acetylcholinesterase (EC 3.1.1.7, AChE) is termination of neurotransmission at cholinergic synapses...
  45. ncbi Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e6851. 2009
    ..We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish...
  46. ncbi The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
    ..b>Acetylcholinesterase (AChE) is expressed in mammalian neurons and hematopoietic cells...
  47. ncbi beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
    Manuela Bartolini
    Dipartimento di Scienze Farmaceutiche, , Via Belmeloro 6, 40126 Bologna, Italy
    Biochem Pharmacol 65:407-16. 2003
    The aggregation of beta-amyloid (1-40) (Abeta) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by thioflavin T fluorescence spectroscopy...
  48. ncbi Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain
    Glynis Johnson
    Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Biochem J 411:507-14. 2008
    Although the primary function of AChE (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth ..
  49. ncbi Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.)
    Stefano Cassanelli
    Department of Agricultural Science, University of Modena and Reggio Emilia, Reggio Emilia, Via JFK Kennedy 17 19, RE 42100, Italy
    Insect Biochem Mol Biol 36:642-53. 2006
    ..In the Raz strain, a target site resistance mechanism was suggested by the inhibition of acetylcholinesterase (AChE) activity...
  50. ncbi Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:1127-31. 2004
    In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract ..
  51. ncbi Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptides
    Susan A Greenfield
    The Institute for the Future of the Mind, Oxford University, UK
    FEBS J 275:604-11. 2008
    This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration...
  52. ncbi P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions
    Edmund K K Tung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Rd, Hong Kong SAR, China
    Mol Pharmacol 66:794-806. 2004
    ..In differentiated myotubes, P2Y2 activation induced expression of acetylcholinesterase (AChE) protein (but not control alpha-tubulin)...
  53. ncbi Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyri
    Abdelouahid Samadi
    Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
    Bioorg Med Chem 18:5861-72. 2010
    ..The biological evaluation showed that some of these molecules were modest inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in the micromolar range...
  54. ncbi Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors
    Ling Huang
    The Industrial Institute of Fine Chemicals and Synthetic Drugs, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China
    Bioorg Med Chem 18:1244-51. 2010
    By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Most of the derivatives inhibited AChE in the sub-micromolar range...
  55. ncbi X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement
    H Dvir
    Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 41:10810-8. 2002
    Kinetic and structural data are presented on the interaction with Torpedo californica acetylcholinesterase (TcAChE) of (+)-huperzine A, a synthetic enantiomer of the anti-Alzheimer drug, (-)-huperzine A, and of its natural homologue (-)-..
  56. ncbi Structure and promoter activity of the 5' flanking region of ace-1, the gene encoding acetylcholinesterase of class A in Caenorhabditis elegans
    E Culetto
    Differenciation cellulaire et Croissance, INRA, 2 place Viala, Montpellier, 34060, France
    J Mol Biol 290:951-66. 1999
    We report the structure and the functional activity of the promoter region of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans...
  57. ncbi Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation
    Pelayo Camps
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Barcelona, Spain
    J Med Chem 51:3588-98. 2008
    ..hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), ..
  58. ncbi Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products
    Judith M Rollinger
    Department of Pharmacognosy, Leopold Franzens University of Innsbruck, A 6020 Innsbruck, Austria
    J Med Chem 47:6248-54. 2004
    For the targeting selection of acetylcholinesterase (AChE) inhibitors from natural sources we generated a structure-based pharmacophore model utilizing an in silico filtering experiment for the discovery of promising candidates out of a ..
  59. ncbi Molecular dynamics of acetylcholinesterase
    Tongye Shen
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, Department of Pharmacology, and Department of Physics, University of California San Diego, La Jolla, California 92093 0365, USA
    Acc Chem Res 35:332-40. 2002
    Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface ..
  60. ncbi Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket
    A Ordentlich
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    J Biol Chem 268:17083-95. 1993
    Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338...
  61. ncbi Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
    D S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Proc Natl Acad Sci U S A 98:2089-94. 2001
    ..Gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (AChE) inhibitor. Gal was tested in two preclinical experiments...
  62. ncbi Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface
    A L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    J Biol Chem 275:34260-5. 2000
    In mammalian brain, acetylcholinesterase (AChE) exists mostly as a tetramer of 70-kDa catalytic subunits that are linked through disulfide bonds to a hydrophobic subunit P of approximately 20 kDa...
  63. ncbi Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression
    D Combes
    Differenciation cellulaire et Croissance, INRA, 2 place Viala, Montpellier, 34060, France
    J Mol Biol 300:727-42. 2000
    We report the full coding sequences and the genomic organization of the four genes encoding acetylcholinesterase (AChE) in Caenorhabditis elegans and Caenorhabditis briggsae, in relation to the properties of the encoded enzymes...
  64. ncbi Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution
    H M Greenblatt
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 463:321-6. 1999
    ..We have solved the X-ray crystal structure of GAL bound in the active site of Torpedo californica acetylcholinesterase (TcAChE) to 2.3 A resolution...
  65. ncbi Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease
    Allam A Rao
    Department of Computer Sciences and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
    Med Hypotheses 69:1272-6. 2007
    ..Recent studies revealed that plasma and tissue concentrations of enzymes butyrylcholinesterase and acetylcholinesterase are elevated in type 2 diabetes and Alzheimer's disease. Acetylcholine has anti-inflammatory actions...
  66. ncbi The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity
    Stylianos Tsakiris
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Pharmacol Res 53:1-5. 2006
    Studies have implicated aspartame (ASP) with neurological problems. The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (..
  67. ncbi Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease
    D Muñoz-Torrero
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E 08028 Barcelona, Spain
    Curr Med Chem 15:2433-55. 2008
    ....
  68. ncbi Effects of four rice herbicides on some metabolic and toxicology parameters of teleost fish (Leporinus obtusidens)
    Bibiana Silveira Moraes
    Departamento de Química Laboratório de Bioquímica Adaptativa, Universidade Federal de Santa Maria UFSM, 97105 900 Santa Maria, RS, Brazil
    Chemosphere 68:1597-601. 2007
    Effects of different herbicides on acetylcholinesterase (AChE), catalase and TBARS formation in teleost fish (Leporinus obtusidens) were studied. Fish were exposed during 30 days at concentrations of herbicides used in rice field...
  69. ncbi The visual pulvinar in tree shrews I. Multiple subdivisions revealed through acetylcholinesterase and Cat-301 chemoarchitecture
    David C Lyon
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, Tennessee 37203, USA
    J Comp Neurol 467:593-606. 2003
    ..The results revealed three major subdivisions. A dorsal subdivision, Pd, stains darkly for acetylcholinesterase (AChE) and occupies the dorsoposterior one-third of the pulvinar complex...
  70. ncbi Complex regulation of acetylcholinesterase gene expression in human brain tumors
    Chava Perry
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel 91904
    Oncogene 21:8428-41. 2002
    To study the regulation of acetylcholinesterase (AChE) gene expression in human brain tumors, 3' splice variants of AChE mRNA and potentially relevant transcription factor mRNAs were labeled in primary astrocytomas and melanomas...
  71. ncbi Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro
    Ava J Y Guo
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, China
    Chem Biol Interact 187:246-8. 2010
    b>Acetylcholinesterase (AChE) inhibitors are widely used for the treatment of Alzheimer's disease (AD). Several AChE inhibitors, e.g...
  72. ncbi Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
    Yechun Xu
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Protein Sci 17:601-5. 2008
    Crystal structures of acetylcholinesterase complexed with ligands are compared with side-chain conformations accessed by native acetylcholinesterase in molecular dynamics (MD) simulations...
  73. ncbi Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system
    Joana C Costa
    Centre for Plant Sciences, University of Leeds, Leeds, UK
    Int J Parasitol 39:849-58. 2009
    ..Here we report, to our knowledge, the first isolation of cyst nematode ace-2 genes encoding acetylcholinesterase (AChE)...
  74. ncbi Architectonic subdivision of the human orbital and medial prefrontal cortex
    Dost Ongur
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Comp Neurol 460:425-49. 2003
    ..The parallel organization of the OMPFC in monkeys and humans allows experimental data from monkeys to be applied to studies of the human cortex...
  75. ncbi Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
    Nibaldo C Inestrosa
    CRCP Biomedical Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
    FEBS J 275:625-32. 2008
    b>Acetylcholinesterase is an enzyme associated with senile plaques...
  76. ncbi Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from Mozambique
    S Casimiro
    National Malaria Control Program, National Direction of Health, Av. Eduardo Mondlane/Salvador Allende, P.O. Box 264, Maputo, Mozambique
    J Med Entomol 43:276-82. 2006
    ..Increased frequencies of insecticide insensitive acetylcholinesterase, the target site for carbamates and organophosphates, were found in 16 of the populations tested...
  77. ncbi Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 259:133-9. 2009
    ..The toxic symptomatology is caused by inhibition of acetylcholinesterase (AChE)...
  78. ncbi Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos
    Craig E Wheelock
    Department of Entomology and Cancer Research Center, University of California at Davis, Davis, CA 95616, USA
    Aquat Toxicol 74:172-92. 2005
    b>Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of organophosphate (OP) and/or carbamate exposure...
  79. ncbi Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality
    E G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Pharmacol Exp Ther 299:528-35. 2001
    The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice...
  80. ncbi Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition
    Lisa R Fodero
    Laboratory of Molecular Neurobiology, Department of Pathology, The University of Melbourne, Melbourne, Australia
    J Neurochem 81:441-8. 2002
    Previous studies have shown that a minor glycoform of acetylcholinesterase (AChE) is increased in Alzheimer's disease brain and cerebrospinal fluid...
  81. ncbi Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide
    Javier Saez-Valero
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, 03550 San Juan de Alicante, Spain
    Neurosci Lett 325:199-202. 2002
    Previous studies have shown that an abnormal salt-soluble form of G(1) acetylcholinesterase (AChE) is increased in the Alzheimer's disease (AD) brain...
  82. ncbi Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramer
    Alemayehu A Gorfe
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Biophys J 97:897-905. 2009
    ..reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt)...
  83. ncbi Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male rats
    Rasiah Pratheepa Kumari
    Department of Biotechnology, Bharathidasan University, Trichy, 620024, India
    Neurochem Res 36:1344-52. 2011
    ....
  84. ncbi Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    J Mol Neurosci 30:65-6. 2006
    ..Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms...
  85. ncbi Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer
    Vincenzo Tumiatti
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 51:7308-12. 2008
    ..15 was the most interesting, inhibiting AChE in the nanomolar range and inhibiting AChE-induced and self-promoted beta-amyloid aggregation in the micromolar range...
  86. ncbi Dynamics of the acetylcholinesterase tetramer
    Alemayehu A Gorfe
    Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093 0365, USA
    Biophys J 94:1144-54. 2008
    b>Acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. The tetramer is the most important functional form of the enzyme...
  87. ncbi Two cholinesterase activities and genes are present in amphioxus
    D Sutherland
    Division of Science and Mathematics, Birmingham Southern College, Alabama 35254, USA
    J Exp Zool 277:213-29. 1997
    To obtain information about the evolution of the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the vertebrates, we investigated the cholinesterase (ChE) activity of the cephalochordate amphioxus (..
  88. ncbi Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow muscles
    E Krejci
    , Centre National de la Recherche Scientifique, , , 75005 Paris, France
    J Neurosci 19:10672-9. 1999
    The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions...
  89. ncbi Monoclonal antibodies to rat brain acetylcholinesterase: comparative affinity for soluble and membrane-associated enzyme and for enzyme from different vertebrate species
    Z Rakonczay
    J Neurochem 46:280-7. 1986
    Seven unique monoclonal antibodies were generated to rat brain acetylcholinesterase. Upon density gradient ultracentrifugation, immunoglobulin complexes with the monomeric enzyme appeared as single peaks of acetylcholinesterase activity ..
  90. ncbi Expression of a cDNA encoding the glycolipid-anchored form of rat acetylcholinesterase
    C Legay
    Laboratoire de Neurobiologie, CNRS UA 295, Ecole Normale Superieure, Paris, France
    FEBS Lett 315:163-6. 1993
    ..PCR and characterized a fragment of cDNA from rat spleen, encoding the distinctive C-terminal region of the acetylcholinesterase (AChE) H subunit...
  91. ncbi In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase
    Lucie Musilova
    Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    Clin Toxicol (Phila) 47:545-50. 2009
    ..are highly toxic to humans and other living organisms, primarily because of their interaction with enzyme acetylcholinesterase. The aim of our study was to find suitable reactivators of acetylcholinesterase and butyrylcholinesterase ..
  92. ncbi Development of sensors for direct detection of organophosphates. Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supports
    A K Singh
    Sandia National Laboratories, Chemical and Radiation Detection Laboratory, Livermore, CA 94551 0969, USA
    Biosens Bioelectron 14:703-13. 1999
    Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms...
  93. ncbi Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization
    C Legay
    Laboratoire de Neurobiologie, CNRS URA 295, Ecole Normale Superieure, Paris, France
    Eur J Neurosci 7:1803-9. 1995
    We studied the splicing and compartmentalization of acetylcholinesterase (AchE) mRNAs during muscle differentiation in the mouse, both in vitro and in vivo...
  94. ncbi Acetylcholinesterase and butyrylcholinesterase of freshwater teleosts
    Grigorii Chuiko
    Institute of Biology of Inlands Waters RAS, Borok, Yaroslavl, Russia
    Chem Biol Interact 157:365-6. 2005
    Long period there was opinion that tissues of freshwater teleosts contain solely acetylcholinesterase (AChE; EC 3.1.1.7), while butyrylcholinesterase (BuChE; EC 3.1.1.8) is present in traces...
  95. ncbi Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer's disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission ..
  96. ncbi Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants
    Ofer Cohen
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona 74100, Israel
    J Biol Chem 282:35491-501. 2007
    ..Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs ..
  97. ncbi Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes
    V Marcel
    Laboratoire de Synthèse et Physicochimie des Molécules d Intérêt Biologique, ESA 5068, Groupe de Biochimie des Protéines, Universite Paul Sabatier, 31062 Toulouse, France
    J Biol Chem 275:11603-9. 2000
    ..However, one of these two components is sometimes lacking. In Drosophila acetylcholinesterase, the two phases are present, allowing both phenomena to be studied...
  98. ncbi Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibers
    Neva Crne-Finderle
    Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 157:23-7. 2005
    The asymmetric A12 acetylcholinesterase (AChE) molecular form, consisting of three tetrameric catalytic oligomers and three non-catalytic subunits of collagen Q (ColQ), is the functional AChE form in the neuromuscular junction...
  99. ncbi Structural and functional organization of synaptic acetylcholinesterase
    Rebeca Aldunate
    , MIFAB, , , 114-D Santiago, Chile
    Brain Res Brain Res Rev 47:96-104. 2004
    The expression of the synaptic asymmetric form of the enzyme acetylcholinesterase (AChE) depends of two different genes: the gene that encodes for the catalytic subunit and the gene that encodes for the collagenic tail, ColQ...
  100. ncbi Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats
    Masanao Kawachi
    Central Research Laboratories, Zeria Pharmaceutical Co, Ltd, 2512 1 Numagami, Oshikiri, Kumagaya shi, Saitama, Japan
    Eur J Pharmacol 666:218-25. 2011
    ..We also examined in vitro the compound's inhibitory effect on acetylcholinesterase (AChE) activity derived from rat stomach. In in vivo studies, acotiamide (30 and 100mg/kg s.c...
  101. ncbi Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis
    Päivi P Oinonen
    Drug Discovery and Development Technology Center, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Fitoterapia 77:429-34. 2006
    Linarin (acacetin-7-O-beta-d-rutinoside) from the flower extract of Mentha arvensis showed selective dose dependent inhibitory effect on acetylcholinesterase.

Research Grants84

  1. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2007
    ..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
  2. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy Lahiri; Fiscal Year: 2009
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  3. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
    ..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
  4. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 1993
    ..messenger cyclic adenosine monophosphate (cAMP), prostaglandin E2 (PGE2) in muscle, and (3) depressed acetylcholinesterase enzyme activity with resultant decreased breakdown and increased levels of acetylcholine at the ..
  5. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
  6. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
  7. Use of an Organophosphorus (OP) Hydrolase for Acute OP Poisoning
    Steven Bird; Fiscal Year: 2007
    ..The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  8. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2010
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  9. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  10. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  11. Development of vector-specific, resistance-breaking insecticides to reduce malari
    PAUL CARLIER; Fiscal Year: 2009
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  12. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2010
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  13. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ..Nerve agents are organophosphates with high toxicity, whose primary action is the irreversible inhibition of acetylcholinesterase. Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, ..
  14. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2010
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  15. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2007
    ..In addition to septohippocampal acetylcholine (ACh) routes of action, experiments will assess acetylcholinesterase inhibition (AChE-I) and nicotinic acetylcholine receptors (nAChRs) in cerebellum and cerebellar ..
  16. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
  17. Metabolism and Age-Related Organophosphate Toxicity
    Janice Chambers; Fiscal Year: 2005
    ..of hepatic and blood detoxication mechanisms (the protective esterases: carboxylesterases, non-target acetylcholinesterase, butyrylcholinesterase, A-esterase) and target enzyme (brain and peripheral acetylcholinesterase) ..
  18. The neurogenic potential of cholinergic activation in AD.
    ELIZABETH ADAMS ECKMAN; Fiscal Year: 2010
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  19. The neurogenic potential of cholinergic activation in AD.
    Elizabeth Eckman; Fiscal Year: 2009
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  20. Organophosphate Action in the Central Nervous System
    NEIL MARC NATHANSON; Fiscal Year: 2010
    Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
  21. PRESYNAPTIC MODULATION OF ANTICHOLINESTERASE TOXICITY
    Carey Pope; Fiscal Year: 2000
    ..from the Investigator's Abstract) Organophosphorus insecticides (OPs) exert toxicity through inhibition of acetylcholinesterase, allowing accumulation of acetylcholine and excessive stimulation of postsynaptic cholinergic receptors...