acetylcholinesterase

Summary

Summary: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Top Publications

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
  2. doi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
  3. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  4. pmc Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
    Yanhui Lu
    Department of Entomology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e32288. 2012
  5. pmc Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e6851. 2009
  6. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005
  7. ncbi Induction of acetylcholinesterase expression during apoptosis in various cell types
    X J Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell Death Differ 9:790-800. 2002
  8. ncbi A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress
    Rinat Kehat
    Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
    Invest Ophthalmol Vis Sci 48:1290-7. 2007
  9. ncbi Molecular, biochemical and histochemical characterization of two acetylcholinesterase cDNAs from the German cockroach Blattella germanica
    J I Kim
    School of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Insect Mol Biol 15:513-22. 2006
  10. pmc Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae
    Haobo Jiang
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Insect Biochem Mol Biol 39:646-53. 2009

Detail Information

Publications316 found, 100 shown here

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
    ..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
  2. doi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
    ..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
  3. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  4. pmc Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
    Yanhui Lu
    Department of Entomology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e32288. 2012
    Since the report of a paralogous acetylcholinesterase (AChE, EC3.1.1.7) gene in the greenbug (Schizaphis graminum) in 2002, two different AChE genes (Ace1 and Ace2) have been identified in each of at least 27 insect species...
  5. pmc Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e6851. 2009
    ..We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish...
  6. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005
    Long-lasting alternative splicing of neuronal acetylcholinesterase (AChE) pre-mRNA occurs during neuronal development and following stress, altering synaptic properties...
  7. ncbi Induction of acetylcholinesterase expression during apoptosis in various cell types
    X J Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell Death Differ 9:790-800. 2002
    b>Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission...
  8. ncbi A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress
    Rinat Kehat
    Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
    Invest Ophthalmol Vis Sci 48:1290-7. 2007
    To study the involvement of stress-induced acetylcholinesterase (AChE) expression in light-induced retinal damage in albino rats.
  9. ncbi Molecular, biochemical and histochemical characterization of two acetylcholinesterase cDNAs from the German cockroach Blattella germanica
    J I Kim
    School of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Insect Mol Biol 15:513-22. 2006
    ..Bgace2 transcript is found only in the subset of neurones, particularly in the cell body. In addition, certain neurones were observed to express Bgace1 only...
  10. pmc Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae
    Haobo Jiang
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Insect Biochem Mol Biol 39:646-53. 2009
    ..Furthermore, we found that choline inhibited r-AgAChE1, a phenomenon related to the enzyme activity decrease at high concentrations of acetylcholine...
  11. ncbi Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation
    I Nijholt
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Mol Psychiatry 9:174-83. 2004
    ..neurophysiological and behavioral findings attributing much of this effect to alternative splicing of the acetylcholinesterase (AChE) gene in hippocampal neurons...
  12. ncbi Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies
    M Shapira
    Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Givat Ram
    J Mol Neurosci 17:1-12. 2001
    ..Because acetylcholinesterase (AChE) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we ..
  13. ncbi Expression and localization of acetylcholinesterase at the neuromuscular junction
    Richard L Rotundo
    Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurocytol 32:743-66. 2003
    b>Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ)...
  14. pmc Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
    Heidi Q Xie
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
    J Biol Chem 285:11537-46. 2010
    In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor)...
  15. ncbi Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
    Z Argov
    Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neurology 69:699-700. 2007
  16. doi Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa)
    K R Dabire
    Institut de Recherche en Sciences de la Santé Centre Muraz, Bobo Dioulasso, Burkina Faso
    Trop Med Int Health 14:396-403. 2009
    ..at 20 localities across the three different agro-climatic zones of Burkina Faso, the distribution of the acetylcholinesterase insensitive mutation ace-1(R), which confers resistance to organophosphates (OP) and carbamates (CM) ..
  17. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  18. doi Silencing of acetylcholinesterase gene of Helicoverpa armigera by siRNA affects larval growth and its life cycle
    Maneesh Kumar
    Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India
    J Insect Physiol 55:273-8. 2009
    ..We studied the effect of siRNA on larval development by selective targeting of the acetylcholinesterase (AChE) gene of Helicoverpa armigera. Chemically synthesized siRNA molecules were directly fed to H...
  19. ncbi An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae
    Takeshi Nabeshima
    Laboratory of Applied Zoology E407, Department of Agriculture and Forestry, Institute of Agriculture and Forestry, University of Tsukuba, Tennodai 1 1 1, Ibaraki, 305 8572, Japan
    Biochem Biophys Res Commun 307:15-22. 2003
    ..However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains. This substitution was located in the acyl pocket of the enzyme and was thought to alter the ligand specificity...
  20. ncbi Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology
    Amit Berson
    The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Brain 131:109-19. 2008
    ..One known link involves synaptic acetylcholinesterase (AChE-S), shown to accelerate amyloid fibrils formation...
  21. ncbi Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase
    R N'Guessan
    Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
    Med Vet Entomol 17:19-25. 2003
    ..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
  22. doi Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization
    Yingjun Zhao
    Shanghai Medical College, Fudan University, Shanghai, China
    Hepatology 53:493-503. 2011
    b>Acetylcholinesterase (ACHE) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. However, the roles and implications of ACHE in hepatocellular carcinoma (HCC) remain elusive...
  23. ncbi Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae)
    I V Coutinho-Abreu
    Laboratorio de Genetica Molecular Humana, Departamento de Genetica, UFPE, Recife PE, Brazil
    J Med Entomol 44:639-50. 2007
    b>Acetylcholinesterase (AChE) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides...
  24. pmc Ace-1 duplication in Anopheles gambiae: a challenge for malaria control
    Luc Djogbenou
    Institut de Recherche pour le Developpement, UR 016, Cotonou, Benin
    Malar J 8:70. 2009
    ..malaria, resistance to organophosphates and carbamates is mainly due to a single amino-acid substitution in acetylcholinesterase 1 (AChE1). This mutation entails a large fitness cost...
  25. ncbi Targeting acetylcholinesterase to treat neurodegeneration
    Ulrike Holzgrabe
    Institute of Pharmacy and Food Chemistry, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Expert Opin Ther Targets 11:161-79. 2007
    ..treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (AChE), the latter being able to increase the concentration of acetylcholine...
  26. pmc Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit
    Alexandre Dobbertin
    Universite Paris Descartes, Paris, France
    J Neurosci 29:4519-30. 2009
    b>Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA)...
  27. doi Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity
    Magdalini A Papandreou
    Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Greece
    Behav Brain Res 198:352-8. 2009
    ..PrB30) and 60 (PrB60) mg/kg body weight for 7 days, on cognitive performance, brain oxidative status and acetylcholinesterase activity in adult, male, 3-4-month-old Balb-c mice...
  28. ncbi Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  29. ncbi Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Krøyer)
    Anders Fallang
    The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Pest Manag Sci 60:1163-70. 2004
    b>Acetylcholinesterase (AChE) is the target of a major pesticide family, the organophosphates, which were extensively used as control agents of sea lice on farmed salmonids in the early 1990s...
  30. ncbi Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.)
    Stefano Cassanelli
    Department of Agricultural Science, University of Modena and Reggio Emilia, Reggio Emilia, Via JFK Kennedy 17 19, RE 42100, Italy
    Insect Biochem Mol Biol 36:642-53. 2006
    ..In the Raz strain, a target site resistance mechanism was suggested by the inhibition of acetylcholinesterase (AChE) activity...
  31. doi Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations
    Haoues Alout
    Team Genomic of Adaptation, CNRS UMR 5554, Institut des Sciences de l Evolution, C C 065, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier, France
    Insect Biochem Mol Biol 39:884-91. 2009
    Two amino acid substitutions in acetylcholinesterase 1 (AChE1), G119S and F290V, are responsible for resistance to organophosphate and carbamate insecticides in Culex pipiens mosquitoes...
  32. ncbi Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission
    Gabriel Zimmerman
    The Institute of Life Sciences and the Interdisciplinary Center for Neural Computation ICNC, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Cell Tissue Res 326:655-69. 2006
    ..This unique termination mechanism makes acetylcholinesterase (AChE), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling...
  33. ncbi Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    Liat BenMoyal-Segal
    The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
    FASEB J 19:452-4. 2005
    ..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
  34. doi Berberine: a potential multipotent natural product to combat Alzheimer's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Molecules 16:6732-40. 2011
    ..In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and ..
  35. ncbi Integrated use of biomarkers (acetylcholinesterase and antioxidant enzymes activities) in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine area
    M G Lionetto
    Lab di Fisiologia Generale ed Ambientale, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita di Lecce, via prov le Lecce Monteroni, Italy
    Mar Pollut Bull 46:324-30. 2003
    ..The aim of the present work was the field application of the integrated use of acetylcholinesterase (AChE) and antioxidant enzymes (catalase--CAT, glutathione peroxidase--GSH-Px), for detecting the possible ..
  36. ncbi Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments
    O Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
    Mol Psychiatry 7:874-85. 2002
    ..were explored in behaviorally impaired transgenic (Tg) FVB/N mice expressing synaptic human acetylcholinesterase (hAChE-S)...
  37. ncbi The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
    ..b>Acetylcholinesterase (AChE) is expressed in mammalian neurons and hematopoietic cells...
  38. ncbi Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia
    C Perry
    Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leukemia 21:1472-80. 2007
    Hematological changes induced by various stress stimuli are accompanied by replacement of the primary acetylcholinesterase (AChE) 3' splice variant acetylcholinesterase-S (AChE-S) with the myelopoietic acetylcholinesterase-R (AChE-R) ..
  39. doi Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Brain Behav Immun 23:41-5. 2009
    ..Here we report that brain acetylcholinesterase activity controls systemic and organ specific TNF production during endotoxemia...
  40. pmc Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008
    ....
  41. doi Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
    Marco Giorgetti
    Medivation, Inc, San Francisco, California 94105, USA
    J Pharmacol Exp Ther 333:748-57. 2010
    ..Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and the N-methyl-d-aspartate (NMDA) receptor, the low in vitro affinity for these targets suggests ..
  42. doi Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata
    Pradeep Kumar
    Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India
    Phytother Res 23:172-7. 2009
    ..Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata...
  43. doi Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
  44. pmc Differential localization of acetylcholinesterase in neuronal and non-neuronal cells
    Matthew D Thullbery
    Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    J Cell Biochem 96:599-610. 2005
    b>Acetylcholinesterase (AChE) expression is regulated in cell types at the transcriptional and translational levels...
  45. doi Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase
    Dong Liang
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    J Biol Chem 284:5195-207. 2009
    The mammalian protein CutA was first discovered in a search for the membrane anchor of mammalian brain acetylcholinesterase (AChE). It was co-purified with AChE, but it is distinct from the real transmembrane anchor protein, PRiMA...
  46. pmc ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities
    D Grisaru
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Mol Med 7:93-105. 2001
    ..Here we report the involvement of the stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, and its 26 amino acid C-terminal domain (ARP) in hematopoietic stress responses...
  47. ncbi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Biol Pharm Bull 32:1433-8. 2009
    ..Coptidis Rhizoma were evaluated via beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) assays, along with peroxynitrite (ONOO(-)) scavenging and total ..
  48. ncbi High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
    K Ingkaninan
    Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
    J Chromatogr A 872:61-73. 2000
    ..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
  49. ncbi A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation
    G V De Ferrari
    Center for Cell Regulation and Pathology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic University of Chile and Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
    Biochemistry 40:10447-57. 2001
    b>Acetylcholinesterase (AChE) has been found to be associated with the core of senile plaques...
  50. ncbi Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
    M F Frasco
    IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
    Biomarkers 10:360-75. 2005
    The enzymatic activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
  51. ncbi Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
    Martina Zimmermann
    Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 90:1489-99. 2004
    b>Acetylcholinesterase inhibitors (AChEIs) are the only currently available drugs for treating Alzheimer's Disease (AD)...
  52. doi Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds
    Pelayo Camps
    Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Med Chem 52:5365-79. 2009
    Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) ..
  53. pmc Structural insights into substrate traffic and inhibition in acetylcholinesterase
    Jacques Philippe Colletier
    Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale CEA CNRS UJF, Grenoble Cedex, France
    EMBO J 25:2746-56. 2006
    b>Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine...
  54. pmc Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase
    K Tai
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 81:715-24. 2001
    A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with special attention paid to the fluctuation in the width of the gorge and opening events of the back door...
  55. ncbi Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis
    R Deng
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Oncogene 25:7070-7. 2006
    It has been shown that acetylcholinesterase (AChE) expression was induced during apoptosis and the anti-sense oligonucleotides and siRNA of AChE may prevent apoptosis in various cell types...
  56. ncbi Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to organophosphorus insecticides
    Ju Chun Hsu
    Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Council of Agriculture, 11 Kuang Ming Road, Wufeng 413, Taichung Hsien, Taiwan
    Insect Biochem Mol Biol 36:396-402. 2006
    Mutations in the gene encoding the enzyme acetylcholinesterase (AChE) of the oriental fruit fly, Bactrocera dorsalis, associated with resistance to an organophosphorus insecticide have been characterized...
  57. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
    ..Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein ..
  58. ncbi Molecular and biochemical characterization of a sand fly population from Sri Lanka: evidence for insecticide resistance due to altered esterases and insensitive acetylcholinesterase
    S N Surendran
    Department of Zoology, University of Jaffna, Jaffna, Sri Lanka
    Bull Entomol Res 95:371-80. 2005
    ..Island collection was assayed for the activities of four enzyme systems involved in insecticide resistance (acetylcholinesterase, non-specific carboxylesterases, glutathione-S-transferases and cytochrome p450 monooxygenases), ..
  59. ncbi Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 110:627-39. 2002
    b>Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways...
  60. ncbi Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors
    Afrim H Bytyqi
    Darmstadt University of Technology, Developmental Biology and Neurogenetics, D 64287 Darmstadt, Germany
    Eur J Neurosci 20:2953-62. 2004
    ..As an alternative, we show here for an acetylcholinesterase (AChE) knockout mouse that photoreceptor degeneration follows an impaired development of the inner retina...
  61. pmc Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e4349. 2009
    ..are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE)...
  62. doi Acetylcholinesterase in cell adhesion, neurite growth and network formation
    Laura E Paraoanu
    Darmstadt University of Technology, Germany
    FEBS J 275:618-24. 2008
    The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative ..
  63. ncbi Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways
    R Hilker
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurology 65:1716-22. 2005
    ..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
  64. pmc N-acetylcholinesterase-induced apoptosis in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 3:e3108. 2008
    ..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.
  65. ncbi Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology
    Israel Silman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Pharmacol 5:293-302. 2005
    The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine...
  66. doi Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    H Shimada
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
    Neurology 73:273-8. 2009
    ..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
  67. ncbi Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity
    M H Oh
    Department of Pharmacy, Pharmacognosy Research Laboratories, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 8WA, UK
    Phytomedicine 11:544-8. 2004
    ..calamus and E. koreanum. The possible bases for the reputation of these and the other herbs tested are discussed in the light of previous investigations into their chemistry and biological activity...
  68. ncbi Two different genes encoding acetylcholinesterase existing in cotton aphid (Aphis gossypii)
    Fei Li
    College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, PR China
    Genome 45:1134-41. 2002
    Two acetylcholinesterase (AChE) genes, Ace1 and Ace2, have been cloned from cotton aphid, Aphis gossypii Glover, using the rapid amplification of cDNA ends (RACE) technique...
  69. ncbi Acetylcholinesterase plays a pivotal role in apoptosome formation
    Sang Eun Park
    Department of Anatomy and Cell Biology BK21 program, Dong A University College of Medicine and Medical Science Research Center, Seo Gu, Busan, South Korea
    Cancer Res 64:2652-5. 2004
    Although a recent study (Zhang et al. Cell Death Differ 2002; 9; 790-800) presented that acetylcholinesterase (AChE) might be an important common component in leading to various types of apoptosis, the molecular mechanism, by which AChE ..
  70. ncbi Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability
    Gerald B Downes
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 270:232-45. 2004
    The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine...
  71. ncbi The peripheral anionic site of acetylcholinesterase: structure, functions and potential role in rational drug design
    G Johnson
    Department of Pediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
    Curr Pharm Des 12:217-25. 2006
    The peripheral anionic site of acetylcholinesterase lies at the entrance to the active site gorge...
  72. doi Calretinin immunohistochemistry versus acetylcholinesterase histochemistry in the evaluation of suction rectal biopsies for Hirschsprung Disease
    Raj P Kapur
    Department of Laboratories, Chidren s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Dev Pathol 12:6-15. 2009
    ..b>Acetylcholinesterase histochemistry (AChE) facilitates diagnosis but is not universally employed, in part because it requires ..
  73. ncbi Molecular characterization of an acetylcholinesterase implicated in the regulation of glucose scavenging by the parasite Schistosoma
    Andrew K Jones
    The School of Biology, University of Leeds, Leeds, West Yorkshire, UK, LS2 9JT
    FASEB J 16:441-3. 2002
    b>Acetylcholinesterase (AChE) present on the surface of the trematode blood fluke Schistosoma has been implicated in the regulation of glucose scavenging from the host blood...
  74. doi Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats
    Virginia C Moser
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 114:113-23. 2010
    N-Methyl carbamate insecticides are reversible inhibitors of central and peripheral acetylcholinesterase (ChE). Despite their widespread use, there are few studies of neurotoxicity in young animals...
  75. doi RNAi of ace1 and ace2 in Blattella germanica reveals their differential contribution to acetylcholinesterase activity and sensitivity to insecticides
    L Revuelta
    Centro de Investigaciones Biologicas, CSIC, Departamento de Biología Medioambiental, Ramiro de Maeztu 9, 28006 Madrid, Spain
    Insect Biochem Mol Biol 39:913-9. 2009
    Cyclorrhapha insect genomes contain a single acetylcholinesterase (AChE) gene while other insects contain at least two ace genes (ace1 and ace2)...
  76. doi Salivary acetylcholinesterase as a biomarker for organophosphate exposure
    Vivian Ng
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Occup Med (Lond) 59:120-2. 2009
    ..Workers exposed to organophosphate (OP) pesticides are required to undergo periodic statutory medical surveillance in several countries...
  77. pmc Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity
    Yong Kyung Lee
    College of Pharmacy, Chungbuk National University, 12, Gaesin dong, Heungduk gu, Cheongju, Chungbuk, 361 763, Korea
    J Nat Med 63:274-82. 2009
    ..officinalis and 4-O-methylhonokiol also dose-dependently attenuated the scopolamine-induced increase of acetylcholinesterase (AChE) activity in the cortex and hippocampus of mice, and inhibited AChE activity in vitro with IC(50) (12 ..
  78. doi Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain
    Ethika Tyagi
    Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, India
    J Neuroimmunol 205:51-6. 2008
    ..Proinflammatory cytokines (TNF-alpha and IL-1beta), acetylcholinesterase (AChE) activity, malondialdehyde (MDA) and reduced glutathione (GSH) were studied as markers for ..
  79. doi Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure
    S K Richetti
    Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Neurotoxicology 32:116-22. 2011
    ..the effects of the treatment with cadmium acetate, lead acetate, mercury chloride, and zinc chloride in acetylcholinesterase activity and gene expression pattern, as well as the effects of these treatments in antioxidant competence ..
  80. ncbi Accumulation of nodularin-like compounds from the cyanobacterium Nodularia spumigena and changes in acetylcholinesterase activity in the clam Macoma balthica during short-term laboratory exposure
    Kari K Lehtonen
    Finnish Institute of Marine Research, PO Box 33, FIN 00931 Helsinki, Finland
    Aquat Toxicol 64:461-76. 2003
    ..b>Acetylcholinesterase (AChE) activity was measured from the foot tissue samples taken at 0, 24 and 96 h...
  81. ncbi P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions
    Edmund K K Tung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Rd, Hong Kong SAR, China
    Mol Pharmacol 66:794-806. 2004
    ..In differentiated myotubes, P2Y2 activation induced expression of acetylcholinesterase (AChE) protein (but not control alpha-tubulin)...
  82. doi Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration
    Katarina Pegan
    Laboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 187:96-100. 2010
    The best established role of acetylcholinesterase (EC 3.1.1.7, AChE) is termination of neurotransmission at cholinergic synapses...
  83. ncbi Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
    G V De Ferrari
    Department of Pharmacology and Program in Neurosciences, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    J Biol Chem 276:23282-7. 2001
    Three-dimensional structures of acetylcholinesterase (AChE) reveal a narrow and deep active site gorge with two sites of ligand binding, an acylation site at the base of the gorge, and a peripheral site near the gorge entrance...
  84. ncbi Acetylcholinesterase inhibition in the threeridge mussel (Amblema plicata) by chlorpyrifos: implications for biomonitoring
    W J Doran
    River Studies Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin 54601, USA
    Ecotoxicol Environ Saf 49:91-8. 2001
    ..chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test...
  85. ncbi Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    Ellen G Duysen
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Toxicology 233:60-9. 2007
    Butyrylcholinesterase (EC 3.1.1.8 BChE) is present in all human and mouse tissues, and is more abundant than acetylcholinesterase (EC 3.1.1.7 AChE) in all tissues except brain...
  86. ncbi Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 224:91-9. 2006
    ..OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with ..
  87. doi Layer-by-Layer self-assembled acetylcholinesterase/PAMAM-Au on CNTs modified electrode for sensing pesticides
    Yunhe Qu
    Department of Chemistry, East China Normal University, Shanghai, PR China
    Bioelectrochemistry 77:139-44. 2010
    In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples...
  88. ncbi Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
    W Xie
    Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805, USA
    J Pharmacol Exp Ther 293:896-902. 2000
    b>Acetylcholinesterase (AChE; EC 3.1.1.7) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development...
  89. doi Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptides
    Susan A Greenfield
    The Institute for the Future of the Mind, Oxford University, UK
    FEBS J 275:604-11. 2008
    This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration...
  90. doi Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine
    Lygia Azevedo Marques
    VU University Amsterdam, Faculty of Sciences, Section of Biomolecular Analysis, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Pharm Biomed Anal 53:609-16. 2010
    ..for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE)...
  91. ncbi Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway
    Nibaldo C Inestrosa
    FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Curr Alzheimer Res 2:301-6. 2005
    ..The only treatment for AD has been the use of inhibitors of acetylcholinesterase (AChE) (E.C. 3.1.1.7), which is one of the several proteins associated with amyloid plaque deposits...
  92. pmc Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'Ivoire
    Ludovic P Ahoua Alou
    Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
    Malar J 9:167. 2010
    ..It is, therefore, essential to investigate on the susceptibility of pyrethroid resistant populations of An. gambiae s.s. to these alternative products...
  93. ncbi Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system
    Marko Zivin
    University of Ljubljana, School of Medicine, Institute of Pathophysiology, Brain Research Laboratory, 1000 Ljubljana, Slovenia
    Psychiatr Danub 20:168-73. 2008
    b>Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles...
  94. ncbi beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
    Manuela Bartolini
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Biochem Pharmacol 65:407-16. 2003
    The aggregation of beta-amyloid (1-40) (Abeta) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by thioflavin T fluorescence spectroscopy...
  95. doi Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain
    Glynis Johnson
    Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Biochem J 411:507-14. 2008
    Although the primary function of AChE (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth ..
  96. ncbi Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:1127-31. 2004
    In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract ..
  97. ncbi Acetylcholine synthesis and possible functions during sea urchin development
    C Angelini
    Department of Experimental, Environmental and Applied Biology, University of Genoa, Genoa, Italy
    Eur J Histochem 48:235-43. 2004
    ..b>Acetylcholinesterase (AChE, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; ..
  98. doi Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyri
    Abdelouahid Samadi
    Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
    Bioorg Med Chem 18:5861-72. 2010
    ..The biological evaluation showed that some of these molecules were modest inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in the micromolar range...
  99. doi Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors
    Ling Huang
    The Industrial Institute of Fine Chemicals and Synthetic Drugs, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China
    Bioorg Med Chem 18:1244-51. 2010
    By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Most of the derivatives inhibited AChE in the sub-micromolar range...
  100. ncbi X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement
    H Dvir
    Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 41:10810-8. 2002
    Kinetic and structural data are presented on the interaction with Torpedo californica acetylcholinesterase (TcAChE) of (+)-huperzine A, a synthetic enantiomer of the anti-Alzheimer drug, (-)-huperzine A, and of its natural homologue (-)-..
  101. ncbi Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket
    A Ordentlich
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    J Biol Chem 268:17083-95. 1993
    Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338...

Research Grants89

  1. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2007
    ..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
  2. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy Lahiri; Fiscal Year: 2009
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  3. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
    ..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
  4. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 1993
    ..messenger cyclic adenosine monophosphate (cAMP), prostaglandin E2 (PGE2) in muscle, and (3) depressed acetylcholinesterase enzyme activity with resultant decreased breakdown and increased levels of acetylcholine at the ..
  5. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
  6. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
  7. Use of an Organophosphorus (OP) Hydrolase for Acute OP Poisoning
    Steven Bird; Fiscal Year: 2007
    ..The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  8. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2010
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  9. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  10. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  11. Development of vector-specific, resistance-breaking insecticides to reduce malari
    PAUL CARLIER; Fiscal Year: 2009
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  12. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2010
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  13. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ..Nerve agents are organophosphates with high toxicity, whose primary action is the irreversible inhibition of acetylcholinesterase. Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, ..
  14. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2010
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  15. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2007
    ..In addition to septohippocampal acetylcholine (ACh) routes of action, experiments will assess acetylcholinesterase inhibition (AChE-I) and nicotinic acetylcholine receptors (nAChRs) in cerebellum and cerebellar ..
  16. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
  17. Metabolism and Age-Related Organophosphate Toxicity
    Janice Chambers; Fiscal Year: 2005
    ..of hepatic and blood detoxication mechanisms (the protective esterases: carboxylesterases, non-target acetylcholinesterase, butyrylcholinesterase, A-esterase) and target enzyme (brain and peripheral acetylcholinesterase) ..
  18. The neurogenic potential of cholinergic activation in AD.
    ELIZABETH ADAMS ECKMAN; Fiscal Year: 2010
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  19. The neurogenic potential of cholinergic activation in AD.
    Elizabeth Eckman; Fiscal Year: 2009
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  20. Organophosphate Action in the Central Nervous System
    NEIL MARC NATHANSON; Fiscal Year: 2010
    Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
  21. PRESYNAPTIC MODULATION OF ANTICHOLINESTERASE TOXICITY
    Carey Pope; Fiscal Year: 2000
    ..from the Investigator's Abstract) Organophosphorus insecticides (OPs) exert toxicity through inhibition of acetylcholinesterase, allowing accumulation of acetylcholine and excessive stimulation of postsynaptic cholinergic receptors...