Genomes and Genes
Summary: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 184.108.40.206.
Publications271 found, 100 shown here
- MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesteraseIftach Shaked
Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Immunity 31:965-73. 2009..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
- Acetylcholinesterase--new roles for an old actorH Soreq
Nat Rev Neurosci 2:294-302. 2001..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
- Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neuronsHeidi Q Xie
Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
J Biol Chem 285:11537-46. 2010In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor)...
- Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesteraseK Tai
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
Biophys J 81:715-24. 2001A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with special attention paid to the fluctuation in the width of the gorge and opening events of the back door...
- Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesteraseZ Argov
Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Neurology 69:699-700. 2007
- PRiMA: the membrane anchor of acetylcholinesterase in the brainAnselme L Perrier
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Neuron 33:275-85. 2002As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
- Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesteraseR N'Guessan
Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
Med Vet Entomol 17:19-25. 2003..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
- Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsHyun Ah Jung
Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
Biol Pharm Bull 32:1433-8. 2009..Coptidis Rhizoma were evaluated via beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) assays, along with peroxynitrite (ONOO(-)) scavenging and total ..
- Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicityM F Frasco
IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
Biomarkers 10:360-75. 2005The enzymatic activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
- Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri LankaM Devika B Perera
Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
Malar J 7:168. 2008....
- Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motilityI Mor
The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
J Cell Mol Med 12:479-95. 2008..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
- Induction of acetylcholinesterase expression during apoptosis in various cell typesX J Zhang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Cell Death Differ 9:790-800. 2002b>Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission...
- Differential localization of acetylcholinesterase in neuronal and non-neuronal cellsMatthew D Thullbery
Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
J Cell Biochem 96:599-610. 2005b>Acetylcholinesterase (AChE) expression is regulated in cell types at the transcriptional and translational levels...
- ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activitiesD Grisaru
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
Mol Med 7:93-105. 2001..Here we report the involvement of the stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, and its 26 amino acid C-terminal domain (ARP) in hematopoietic stress responses...
- Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesteraseDong Liang
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
J Biol Chem 284:5195-207. 2009The mammalian protein CutA was first discovered in a search for the membrane anchor of mammalian brain acetylcholinesterase (AChE). It was co-purified with AChE, but it is distinct from the real transmembrane anchor protein, PRiMA...
- Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonismMarco Giorgetti
Medivation, Inc, San Francisco, California 94105, USA
J Pharmacol Exp Ther 333:748-57. 2010..Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and the N-methyl-d-aspartate (NMDA) receptor, the low in vitro affinity for these targets suggests ..
- A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formationG V De Ferrari
Center for Cell Regulation and Pathology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic University of Chile and Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
Biochemistry 40:10447-57. 2001b>Acetylcholinesterase (AChE) has been found to be associated with the core of senile plaques...
- Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminataPradeep Kumar
Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India
Phytother Res 23:172-7. 2009..Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata...
- High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural productsK Ingkaninan
Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
J Chromatogr A 872:61-73. 2000..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
- Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell linesMartina Zimmermann
Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Neurochem 90:1489-99. 2004b>Acetylcholinesterase inhibitors (AChEIs) are the only currently available drugs for treating Alzheimer's Disease (AD)...
- Structural insights into substrate traffic and inhibition in acetylcholinesteraseJacques-Philippe Colletier
, Institut de Biologie Structurale (CEA/CNRS/UJF, Grenoble Cedex, France
EMBO J 25:2746-56. 2006b>Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine...
- Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compoundsPelayo Camps
Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
J Med Chem 52:5365-79. 2009Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) ..
- N-acetylcholinesterase-induced apoptosis in Alzheimer's diseaseDebra Toiber
Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
PLoS ONE 3:e3108. 2008..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.
- Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathologyAmit Berson
The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Brain 131:109-19. 2008..One known link involves synaptic acetylcholinesterase (AChE-S), shown to accelerate amyloid fibrils formation...
- Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacologyIsrael Silman
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Curr Opin Pharmacol 5:293-302. 2005The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine...
- Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathwaysR Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Neurology 65:1716-22. 2005..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
- Mapping of brain acetylcholinesterase alterations in Lewy body disease by PETH Shimada
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
Neurology 73:273-8. 2009..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
- Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stabilityGerald B Downes
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Dev Biol 270:232-45. 2004The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine...
- A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stressRinat Kehat
Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
Invest Ophthalmol Vis Sci 48:1290-7. 2007To study the involvement of stress-induced acetylcholinesterase (AChE) expression in light-induced retinal damage in albino rats.
- Acetylcholinesterase in cell adhesion, neurite growth and network formationLaura E Paraoanu
Darmstadt University of Technology, Germany
FEBS J 275:618-24. 2008The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative ..
- Accumulation of nodularin-like compounds from the cyanobacterium Nodularia spumigena and changes in acetylcholinesterase activity in the clam Macoma balthica during short-term laboratory exposureKari K Lehtonen
Finnish Institute of Marine Research, PO Box 33, FIN 00931 Helsinki, Finland
Aquat Toxicol 64:461-76. 2003..b>Acetylcholinesterase (AChE) activity was measured from the foot tissue samples taken at 0, 24 and 96 h...
- Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous systemMarko Zivin
University of Ljubljana, School of Medicine, Institute of Pathophysiology, Brain Research Laboratory, 1000 Ljubljana, Slovenia
Psychiatr Danub 20:168-73. 2008b>Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles...
- Acetylcholinesterase inhibition in the threeridge mussel (Amblema plicata) by chlorpyrifos: implications for biomonitoringW J Doran
River Studies Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin 54601, USA
Ecotoxicol Environ Saf 49:91-8. 2001..chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test...
- Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sitesG V De Ferrari
Department of Pharmacology and Program in Neurosciences, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
J Biol Chem 276:23282-7. 2001Three-dimensional structures of acetylcholinesterase (AChE) reveal a narrow and deep active site gorge with two sites of ligand binding, an acylation site at the base of the gorge, and a peripheral site near the gorge entrance...
- Layer-by-Layer self-assembled acetylcholinesterase/PAMAM-Au on CNTs modified electrode for sensing pesticidesYunhe Qu
Department of Chemistry, East China Normal University, Shanghai, PR China
Bioelectrochemistry 77:139-44. 2010In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples...
- Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathwayNibaldo C Inestrosa
FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
Curr Alzheimer Res 2:301-6. 2005..The only treatment for AD has been the use of inhibitors of acetylcholinesterase (AChE) (E.C. 220.127.116.11), which is one of the several proteins associated with amyloid plaque deposits...
- Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesteraseN Aurbek
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
Toxicology 224:91-9. 2006..OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with ..
- Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrineLygia Azevedo Marques
VU University Amsterdam, Faculty of Sciences, Section of Biomolecular Analysis, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
J Pharm Biomed Anal 53:609-16. 2010..for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE)...
- Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesteraseW Xie
Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805, USA
J Pharmacol Exp Ther 293:896-902. 2000b>Acetylcholinesterase (AChE; EC 18.104.22.168) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development...
- Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Krøyer)Anders Fallang
The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
Pest Manag Sci 60:1163-70. 2004b>Acetylcholinesterase (AChE) is the target of a major pesticide family, the organophosphates, which were extensively used as control agents of sea lice on farmed salmonids in the early 1990s...
- Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'IvoireLudovic P Ahoua Alou
Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
Malar J 9:167. 2010..It is, therefore, essential to investigate on the susceptibility of pyrethroid resistant populations of An. gambiae s.s. to these alternative products...
- Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmissionEllen G Duysen
Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Toxicology 233:60-9. 2007Butyrylcholinesterase (EC 22.214.171.124 BChE) is present in all human and mouse tissues, and is more abundant than acetylcholinesterase (EC 126.96.36.199 AChE) in all tissues except brain...
- Acetylcholine synthesis and possible functions during sea urchin developmentC Angelini
Department of Experimental, Environmental and Applied Biology, University of Genoa, Genoa, Italy
Eur J Histochem 48:235-43. 2004..b>Acetylcholinesterase (AChE, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; ..
- Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regenerationKatarina Pegan
Laboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 187:96-100. 2010The best established role of acetylcholinesterase (EC 188.8.131.52, AChE) is termination of neurotransmission at cholinergic synapses...
- Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseasesYuan Ping Pang
Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 4:e6851. 2009..We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish...
- The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferationVarda R Deutsch
Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Exp Hematol 30:1153-61. 2002..b>Acetylcholinesterase (AChE) is expressed in mammalian neurons and hematopoietic cells...
- beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studiesManuela Bartolini
Dipartimento di Scienze Farmaceutiche, , Via Belmeloro 6, 40126 Bologna, Italy
Biochem Pharmacol 65:407-16. 2003The aggregation of beta-amyloid (1-40) (Abeta) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by thioflavin T fluorescence spectroscopy...
- Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chainGlynis Johnson
Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
Biochem J 411:507-14. 2008Although the primary function of AChE (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth ..
- Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.)Stefano Cassanelli
Department of Agricultural Science, University of Modena and Reggio Emilia, Reggio Emilia, Via JFK Kennedy 17 19, RE 42100, Italy
Insect Biochem Mol Biol 36:642-53. 2006..In the Raz strain, a target site resistance mechanism was suggested by the inhibition of acetylcholinesterase (AChE) activity...
- Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosaDae Keun Kim
College of Pharmacy, Woosuk University, Samrye 565 701, Korea
Arch Pharm Res 27:1127-31. 2004In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract ..
- Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptidesSusan A Greenfield
The Institute for the Future of the Mind, Oxford University, UK
FEBS J 275:604-11. 2008This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration...
- P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctionsEdmund K K Tung
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Rd, Hong Kong SAR, China
Mol Pharmacol 66:794-806. 2004..In differentiated myotubes, P2Y2 activation induced expression of acetylcholinesterase (AChE) protein (but not control alpha-tubulin)...
- Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyriAbdelouahid Samadi
Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
Bioorg Med Chem 18:5861-72. 2010..The biological evaluation showed that some of these molecules were modest inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in the micromolar range...
- Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitorsLing Huang
The Industrial Institute of Fine Chemicals and Synthetic Drugs, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China
Bioorg Med Chem 18:1244-51. 2010By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Most of the derivatives inhibited AChE in the sub-micromolar range...
- X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangementH Dvir
Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Biochemistry 41:10810-8. 2002Kinetic and structural data are presented on the interaction with Torpedo californica acetylcholinesterase (TcAChE) of (+)-huperzine A, a synthetic enantiomer of the anti-Alzheimer drug, (-)-huperzine A, and of its natural homologue (-)-..
- Structure and promoter activity of the 5' flanking region of ace-1, the gene encoding acetylcholinesterase of class A in Caenorhabditis elegansE Culetto
Differenciation cellulaire et Croissance, INRA, 2 place Viala, Montpellier, 34060, France
J Mol Biol 290:951-66. 1999We report the structure and the functional activity of the promoter region of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans...
- Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregationPelayo Camps
Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Barcelona, Spain
J Med Chem 51:3588-98. 2008..hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), ..
- Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural productsJudith M Rollinger
Department of Pharmacognosy, Leopold Franzens University of Innsbruck, A 6020 Innsbruck, Austria
J Med Chem 47:6248-54. 2004For the targeting selection of acetylcholinesterase (AChE) inhibitors from natural sources we generated a structure-based pharmacophore model utilizing an in silico filtering experiment for the discovery of promising candidates out of a ..
- Molecular dynamics of acetylcholinesteraseTongye Shen
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, Department of Pharmacology, and Department of Physics, University of California San Diego, La Jolla, California 92093 0365, USA
Acc Chem Res 35:332-40. 2002Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface ..
- Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocketA Ordentlich
Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
J Biol Chem 268:17083-95. 1993Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338...
- Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learningD S Woodruff-Pak
Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
Proc Natl Acad Sci U S A 98:2089-94. 2001..Gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (AChE) inhibitor. Gal was tested in two preclinical experiments...
- Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surfaceA L Perrier
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
J Biol Chem 275:34260-5. 2000In mammalian brain, acetylcholinesterase (AChE) exists mostly as a tetramer of 70-kDa catalytic subunits that are linked through disulfide bonds to a hydrophobic subunit P of approximately 20 kDa...
- Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expressionD Combes
Differenciation cellulaire et Croissance, INRA, 2 place Viala, Montpellier, 34060, France
J Mol Biol 300:727-42. 2000We report the full coding sequences and the genomic organization of the four genes encoding acetylcholinesterase (AChE) in Caenorhabditis elegans and Caenorhabditis briggsae, in relation to the properties of the encoded enzymes...
- Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolutionH M Greenblatt
Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
FEBS Lett 463:321-6. 1999..We have solved the X-ray crystal structure of GAL bound in the active site of Torpedo californica acetylcholinesterase (TcAChE) to 2.3 A resolution...
- Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's diseaseAllam A Rao
Department of Computer Sciences and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
Med Hypotheses 69:1272-6. 2007..Recent studies revealed that plasma and tissue concentrations of enzymes butyrylcholinesterase and acetylcholinesterase are elevated in type 2 diabetes and Alzheimer's disease. Acetylcholine has anti-inflammatory actions...
- The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activityStylianos Tsakiris
Department of Experimental Physiology, Medical School, University of Athens, Greece
Pharmacol Res 53:1-5. 2006Studies have implicated aspartame (ASP) with neurological problems. The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (..
- Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseD Muñoz-Torrero
Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E 08028 Barcelona, Spain
Curr Med Chem 15:2433-55. 2008....
- Effects of four rice herbicides on some metabolic and toxicology parameters of teleost fish (Leporinus obtusidens)Bibiana Silveira Moraes
Departamento de Química Laboratório de Bioquímica Adaptativa, Universidade Federal de Santa Maria UFSM, 97105 900 Santa Maria, RS, Brazil
Chemosphere 68:1597-601. 2007Effects of different herbicides on acetylcholinesterase (AChE), catalase and TBARS formation in teleost fish (Leporinus obtusidens) were studied. Fish were exposed during 30 days at concentrations of herbicides used in rice field...
- The visual pulvinar in tree shrews I. Multiple subdivisions revealed through acetylcholinesterase and Cat-301 chemoarchitectureDavid C Lyon
Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, Tennessee 37203, USA
J Comp Neurol 467:593-606. 2003..The results revealed three major subdivisions. A dorsal subdivision, Pd, stains darkly for acetylcholinesterase (AChE) and occupies the dorsoposterior one-third of the pulvinar complex...
- Complex regulation of acetylcholinesterase gene expression in human brain tumorsChava Perry
Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel 91904
Oncogene 21:8428-41. 2002To study the regulation of acetylcholinesterase (AChE) gene expression in human brain tumors, 3' splice variants of AChE mRNA and potentially relevant transcription factor mRNAs were labeled in primary astrocytomas and melanomas...
- Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitroAva J Y Guo
Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, China
Chem Biol Interact 187:246-8. 2010b>Acetylcholinesterase (AChE) inhibitors are widely used for the treatment of Alzheimer's disease (AD). Several AChE inhibitors, e.g...
- Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug designYechun Xu
Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
Protein Sci 17:601-5. 2008Crystal structures of acetylcholinesterase complexed with ligands are compared with side-chain conformations accessed by native acetylcholinesterase in molecular dynamics (MD) simulations...
- Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous systemJoana C Costa
Centre for Plant Sciences, University of Leeds, Leeds, UK
Int J Parasitol 39:849-58. 2009..Here we report, to our knowledge, the first isolation of cyst nematode ace-2 genes encoding acetylcholinesterase (AChE)...
- Architectonic subdivision of the human orbital and medial prefrontal cortexDost Ongur
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Comp Neurol 460:425-49. 2003..The parallel organization of the OMPFC in monkeys and humans allows experimental data from monkeys to be applied to studies of the human cortex...
- Amyloid-cholinesterase interactions. Implications for Alzheimer's diseaseNibaldo C Inestrosa
CRCP Biomedical Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
FEBS J 275:625-32. 2008b>Acetylcholinesterase is an enzyme associated with senile plaques...
- Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from MozambiqueS Casimiro
National Malaria Control Program, National Direction of Health, Av. Eduardo Mondlane/Salvador Allende, P.O. Box 264, Maputo, Mozambique
J Med Entomol 43:276-82. 2006..Increased frequencies of insecticide insensitive acetylcholinesterase, the target site for carbamates and organophosphates, were found in 16 of the populations tested...
- Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysisN Aurbek
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
Toxicology 259:133-9. 2009..The toxic symptomatology is caused by inhibition of acetylcholinesterase (AChE)...
- Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifosCraig E Wheelock
Department of Entomology and Cancer Research Center, University of California at Davis, Davis, CA 95616, USA
Aquat Toxicol 74:172-92. 2005b>Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of organophosphate (OP) and/or carbamate exposure...
- Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethalityE G Duysen
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
J Pharmacol Exp Ther 299:528-35. 2001The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 184.108.40.206) was examined in AChE knockout mice...
- Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque depositionLisa R Fodero
Laboratory of Molecular Neurobiology, Department of Pathology, The University of Melbourne, Melbourne, Australia
J Neurochem 81:441-8. 2002Previous studies have shown that a minor glycoform of acetylcholinesterase (AChE) is increased in Alzheimer's disease brain and cerebrospinal fluid...
- Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptideJavier Saez-Valero
Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, 03550 San Juan de Alicante, Spain
Neurosci Lett 325:199-202. 2002Previous studies have shown that an abnormal salt-soluble form of G(1) acetylcholinesterase (AChE) is increased in the Alzheimer's disease (AD) brain...
- Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramerAlemayehu A Gorfe
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA
Biophys J 97:897-905. 2009..reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt)...
- Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male ratsRasiah Pratheepa Kumari
Department of Biotechnology, Bharathidasan University, Trichy, 620024, India
Neurochem Res 36:1344-52. 2011....
- Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluidMaria Ximena Silveyra
Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
J Mol Neurosci 30:65-6. 2006..Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms...
- Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacerVincenzo Tumiatti
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Med Chem 51:7308-12. 2008..15 was the most interesting, inhibiting AChE in the nanomolar range and inhibiting AChE-induced and self-promoted beta-amyloid aggregation in the micromolar range...
- Dynamics of the acetylcholinesterase tetramerAlemayehu A Gorfe
Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093 0365, USA
Biophys J 94:1144-54. 2008b>Acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. The tetramer is the most important functional form of the enzyme...
- Two cholinesterase activities and genes are present in amphioxusD Sutherland
Division of Science and Mathematics, Birmingham Southern College, Alabama 35254, USA
J Exp Zool 277:213-29. 1997To obtain information about the evolution of the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the vertebrates, we investigated the cholinesterase (ChE) activity of the cephalochordate amphioxus (..
- Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow musclesE Krejci
, Centre National de la Recherche Scientifique, , , 75005 Paris, France
J Neurosci 19:10672-9. 1999The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions...
- Monoclonal antibodies to rat brain acetylcholinesterase: comparative affinity for soluble and membrane-associated enzyme and for enzyme from different vertebrate speciesZ Rakonczay
J Neurochem 46:280-7. 1986Seven unique monoclonal antibodies were generated to rat brain acetylcholinesterase. Upon density gradient ultracentrifugation, immunoglobulin complexes with the monomeric enzyme appeared as single peaks of acetylcholinesterase activity ..
- Expression of a cDNA encoding the glycolipid-anchored form of rat acetylcholinesteraseC Legay
Laboratoire de Neurobiologie, CNRS UA 295, Ecole Normale Superieure, Paris, France
FEBS Lett 315:163-6. 1993..PCR and characterized a fragment of cDNA from rat spleen, encoding the distinctive C-terminal region of the acetylcholinesterase (AChE) H subunit...
- In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesteraseLucie Musilova
Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
Clin Toxicol (Phila) 47:545-50. 2009..are highly toxic to humans and other living organisms, primarily because of their interaction with enzyme acetylcholinesterase. The aim of our study was to find suitable reactivators of acetylcholinesterase and butyrylcholinesterase ..
- Development of sensors for direct detection of organophosphates. Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supportsA K Singh
Sandia National Laboratories, Chemical and Radiation Detection Laboratory, Livermore, CA 94551 0969, USA
Biosens Bioelectron 14:703-13. 1999Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms...
- Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalizationC Legay
Laboratoire de Neurobiologie, CNRS URA 295, Ecole Normale Superieure, Paris, France
Eur J Neurosci 7:1803-9. 1995We studied the splicing and compartmentalization of acetylcholinesterase (AchE) mRNAs during muscle differentiation in the mouse, both in vitro and in vivo...
- Acetylcholinesterase and butyrylcholinesterase of freshwater teleostsGrigorii Chuiko
Institute of Biology of Inlands Waters RAS, Borok, Yaroslavl, Russia
Chem Biol Interact 157:365-6. 2005Long period there was opinion that tissues of freshwater teleosts contain solely acetylcholinesterase (AChE; EC 220.127.116.11), while butyrylcholinesterase (BuChE; EC 18.104.22.168) is present in traces...
- Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's diseaseNicolaas I Bohnen
Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
Neurosci Lett 380:127-32. 2005We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer's disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission ..
- Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutantsOfer Cohen
Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona 74100, Israel
J Biol Chem 282:35491-501. 2007..Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs ..
- Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymesV Marcel
Laboratoire de Synthèse et Physicochimie des Molécules d Intérêt Biologique, ESA 5068, Groupe de Biochimie des Protéines, Universite Paul Sabatier, 31062 Toulouse, France
J Biol Chem 275:11603-9. 2000..However, one of these two components is sometimes lacking. In Drosophila acetylcholinesterase, the two phases are present, allowing both phenomena to be studied...
- Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibersNeva Crne-Finderle
Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 157:23-7. 2005The asymmetric A12 acetylcholinesterase (AChE) molecular form, consisting of three tetrameric catalytic oligomers and three non-catalytic subunits of collagen Q (ColQ), is the functional AChE form in the neuromuscular junction...
- Structural and functional organization of synaptic acetylcholinesteraseRebeca Aldunate
, MIFAB, , , 114-D Santiago, Chile
Brain Res Brain Res Rev 47:96-104. 2004The expression of the synaptic asymmetric form of the enzyme acetylcholinesterase (AChE) depends of two different genes: the gene that encodes for the catalytic subunit and the gene that encodes for the collagenic tail, ColQ...
- Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in ratsMasanao Kawachi
Central Research Laboratories, Zeria Pharmaceutical Co, Ltd, 2512 1 Numagami, Oshikiri, Kumagaya shi, Saitama, Japan
Eur J Pharmacol 666:218-25. 2011..We also examined in vitro the compound's inhibitory effect on acetylcholinesterase (AChE) activity derived from rat stomach. In in vivo studies, acotiamide (30 and 100mg/kg s.c...
- Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensisPäivi P Oinonen
Drug Discovery and Development Technology Center, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Fitoterapia 77:429-34. 2006Linarin (acacetin-7-O-beta-d-rutinoside) from the flower extract of Mentha arvensis showed selective dose dependent inhibitory effect on acetylcholinesterase.
- Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEsRichard Gordon; Fiscal Year: 2007..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy Lahiri; Fiscal Year: 2009..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
- Age and sex effects on nerve agent damage to the brain and antidotal therapiesEDSON ALBUQUERQUE; Fiscal Year: 2007..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
- ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNSJEEVENDRA MARTYN; Fiscal Year: 1993..messenger cyclic adenosine monophosphate (cAMP), prostaglandin E2 (PGE2) in muscle, and (3) depressed acetylcholinesterase enzyme activity with resultant decreased breakdown and increased levels of acetylcholine at the ..
- A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide NeurotoxicityYvonne Rosenberg; Fiscal Year: 2007..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2003..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
- Use of an Organophosphorus (OP) Hydrolase for Acute OP PoisoningSteven Bird; Fiscal Year: 2007..The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
- Pope-Presynaptic modulation of anticholinesterase toxicityCarey N Pope; Fiscal Year: 2010Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2007..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPAUL CARLIER; Fiscal Year: 2009..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPaul R Carlier; Fiscal Year: 2010..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
- Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and NeuropathologyMARIA BRAGA; Fiscal Year: 2007..Nerve agents are organophosphates with high toxicity, whose primary action is the irreversible inhibition of acetylcholinesterase. Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy K Lahiri; Fiscal Year: 2010..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
- Aging and Sites of Action of Cognition-Enhancing DrugsDIANA WOODRUFF PAK; Fiscal Year: 2007..In addition to septohippocampal acetylcholine (ACh) routes of action, experiments will assess acetylcholinesterase inhibition (AChE-I) and nicotinic acetylcholine receptors (nAChRs) in cerebellum and cerebellar ..
- Organophosphorus Pesticide ToxicologyJOHN CASIDA; Fiscal Year: 2006..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
- Metabolism and Age-Related Organophosphate ToxicityJanice Chambers; Fiscal Year: 2005..of hepatic and blood detoxication mechanisms (the protective esterases: carboxylesterases, non-target acetylcholinesterase, butyrylcholinesterase, A-esterase) and target enzyme (brain and peripheral acetylcholinesterase) ..
- The neurogenic potential of cholinergic activation in AD.ELIZABETH ADAMS ECKMAN; Fiscal Year: 2010..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
- The neurogenic potential of cholinergic activation in AD.Elizabeth Eckman; Fiscal Year: 2009..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
- Organophosphate Action in the Central Nervous SystemNEIL MARC NATHANSON; Fiscal Year: 2010Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
- PRESYNAPTIC MODULATION OF ANTICHOLINESTERASE TOXICITYCarey Pope; Fiscal Year: 2000..from the Investigator's Abstract) Organophosphorus insecticides (OPs) exert toxicity through inhibition of acetylcholinesterase, allowing accumulation of acetylcholine and excessive stimulation of postsynaptic cholinergic receptors...