acetylcholinesterase

Summary

Summary: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Top Publications

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
  2. ncbi The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors
    M Weill
    Institut des Sciences de l Evolution UMR 5554, Laboratoire Genetique et Environnement, Universite Montpellier II, Montpellier, France
    Insect Mol Biol 13:1-7. 2004
  3. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  4. ncbi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
  5. ncbi The genetics and genomics of insecticide resistance
    Richard H Ffrench-Constant
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Trends Genet 20:163-70. 2004
  6. pmc Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
    Yanhui Lu
    Department of Entomology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e32288. 2012
  7. pmc Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4
    Badi Sri Sailaja
    Department of Genetics, The Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 109:E3687-95. 2012
  8. pmc Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target
    G Shaltiel
    Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Brain Struct Funct 218:59-72. 2013
  9. pmc Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e6851. 2009
  10. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005

Detail Information

Publications361 found, 100 shown here

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
    ..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
  2. ncbi The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors
    M Weill
    Institut des Sciences de l Evolution UMR 5554, Laboratoire Genetique et Environnement, Universite Montpellier II, Montpellier, France
    Insect Mol Biol 13:1-7. 2004
    High insecticide resistance resulting from insensitive acetylcholinesterase (AChE) has emerged in mosquitoes. A single mutation (G119S of the ace-1 gene) explains this high resistance in Culex pipiens and in Anopheles gambiae...
  3. ncbi Comparative genomics: Insecticide resistance in mosquito vectors
    Mylene Weill
    Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
    Nature 423:136-7. 2003
  4. ncbi MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    Iftach Shaked
    Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Immunity 31:965-73. 2009
    ..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
  5. ncbi The genetics and genomics of insecticide resistance
    Richard H Ffrench-Constant
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Trends Genet 20:163-70. 2004
    ..These studies enable us to address three fundamental questions in the evolution of resistance. How many genes are involved? How many mutations are there within these genes? How often do these mutations arise in natural populations?..
  6. pmc Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
    Yanhui Lu
    Department of Entomology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 7:e32288. 2012
    Since the report of a paralogous acetylcholinesterase (AChE, EC3.1.1.7) gene in the greenbug (Schizaphis graminum) in 2002, two different AChE genes (Ace1 and Ace2) have been identified in each of at least 27 insect species...
  7. pmc Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4
    Badi Sri Sailaja
    Department of Genetics, The Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 109:E3687-95. 2012
    ..Specifically, the AChE gene encoding the acetylcholine-hydrolyzing enzyme acetylcholinesterase is known to undergo long-lasting transcriptional and alternative splicing changes after stress...
  8. pmc Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target
    G Shaltiel
    Edmond and Lily Safra Center of Brain Sciences, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Brain Struct Funct 218:59-72. 2013
    ..demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) target are causally involved...
  9. pmc Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e6851. 2009
    ..We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish...
  10. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005
    Long-lasting alternative splicing of neuronal acetylcholinesterase (AChE) pre-mRNA occurs during neuronal development and following stress, altering synaptic properties...
  11. ncbi Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Brain Behav Immun 23:41-5. 2009
    ..Here we report that brain acetylcholinesterase activity controls systemic and organ specific TNF production during endotoxemia...
  12. ncbi Induction of acetylcholinesterase expression during apoptosis in various cell types
    X J Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell Death Differ 9:790-800. 2002
    b>Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission...
  13. ncbi Acetylcholinesterase inhibitors: a patent review (2008 - present)
    Miroslav Pohanka
    University of Defense, Faculty of Military Health Sciences, Trebesska 1575, 50001 Hradec Kralove, Czech Republic
    Expert Opin Ther Pat 22:871-86. 2012
    Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are present in the body in large amounts. AChE is an important part of the cholinergic nervous system taking place in the central and peripheral nervous system...
  14. ncbi Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
    Seung Hwan Kwon
    Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Eur J Pharmacol 649:210-7. 2010
    ..Ex vivo, chlorogenic acid inhibited acetylcholinesterase activity in the hippocampus and frontal cortex...
  15. ncbi Molecular, biochemical and histochemical characterization of two acetylcholinesterase cDNAs from the German cockroach Blattella germanica
    J I Kim
    School of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Insect Mol Biol 15:513-22. 2006
    ..Bgace2 transcript is found only in the subset of neurones, particularly in the cell body. In addition, certain neurones were observed to express Bgace1 only...
  16. pmc Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae
    Haobo Jiang
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Insect Biochem Mol Biol 39:646-53. 2009
    ..Furthermore, we found that choline inhibited r-AgAChE1, a phenomenon related to the enzyme activity decrease at high concentrations of acetylcholine...
  17. ncbi A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress
    Rinat Kehat
    Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
    Invest Ophthalmol Vis Sci 48:1290-7. 2007
    To study the involvement of stress-induced acetylcholinesterase (AChE) expression in light-induced retinal damage in albino rats.
  18. ncbi Expression and localization of acetylcholinesterase at the neuromuscular junction
    Richard L Rotundo
    Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurocytol 32:743-66. 2003
    b>Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ)...
  19. ncbi Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesterase
    Z Argov
    Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neurology 69:699-700. 2007
  20. pmc Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
    Heidi Q Xie
    Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
    J Biol Chem 285:11537-46. 2010
    In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor)...
  21. pmc Ace-1 duplication in Anopheles gambiae: a challenge for malaria control
    Luc Djogbenou
    Institut de Recherche pour le Developpement, UR 016, Cotonou, Benin
    Malar J 8:70. 2009
    ..malaria, resistance to organophosphates and carbamates is mainly due to a single amino-acid substitution in acetylcholinesterase 1 (AChE1). This mutation entails a large fitness cost...
  22. pmc Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase
    M Harel
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 90:9031-5. 1993
    Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution...
  23. ncbi Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity
    B Vinutha
    Department of Pharmacognosy, Al Ameen College of Pharmacy, Hosur Road, Bangalore, India
    J Ethnopharmacol 109:359-63. 2007
    ..including methanolic and successive water extracts from 37 Indian medicinal plants were investigated for acetylcholinesterase (AChE) inhibitory activity (in vitro)...
  24. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  25. ncbi Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa)
    K R Dabire
    Institut de Recherche en Sciences de la Santé Centre Muraz, Bobo Dioulasso, Burkina Faso
    Trop Med Int Health 14:396-403. 2009
    ..at 20 localities across the three different agro-climatic zones of Burkina Faso, the distribution of the acetylcholinesterase insensitive mutation ace-1(R), which confers resistance to organophosphates (OP) and carbamates (CM) ..
  26. pmc Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation
    Luc Djogbenou
    Institut Régional de Santé Publique Université d Abomey Calavi, Cotonou, Benin
    Malar J 9:12. 2010
    The G119S mutation responsible for insensitive acetylcholinesterase resistance to organophosphate and carbamate insecticides has recently been reported from natural populations of Anopheles gambiae in West Africa...
  27. ncbi Silencing of acetylcholinesterase gene of Helicoverpa armigera by siRNA affects larval growth and its life cycle
    Maneesh Kumar
    Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India
    J Insect Physiol 55:273-8. 2009
    ..We studied the effect of siRNA on larval development by selective targeting of the acetylcholinesterase (AChE) gene of Helicoverpa armigera. Chemically synthesized siRNA molecules were directly fed to H...
  28. ncbi An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae
    Takeshi Nabeshima
    Laboratory of Applied Zoology E407, Department of Agriculture and Forestry, Institute of Agriculture and Forestry, University of Tsukuba, Tennodai 1 1 1, Ibaraki, 305 8572, Japan
    Biochem Biophys Res Commun 307:15-22. 2003
    ..However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains. This substitution was located in the acyl pocket of the enzyme and was thought to alter the ligand specificity...
  29. ncbi Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology
    Amit Berson
    The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Brain 131:109-19. 2008
    ..One known link involves synaptic acetylcholinesterase (AChE-S), shown to accelerate amyloid fibrils formation...
  30. ncbi Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase
    R N'Guessan
    Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
    Med Vet Entomol 17:19-25. 2003
    ..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
  31. ncbi Hydrolysis of organophosphorus insecticides by in vitro modified carboxylesterase E3 from Lucilia cuprina
    R Heidari
    CSIRO Entomology, GPO Box 1700, Canberra, ACT 2601, Australia
    Insect Biochem Mol Biol 34:353-63. 2004
    ..The results are discussed in relation to likely steric effects on enzyme-substrate interactions and future evolution of this gene...
  32. ncbi Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réunion Island
    Michaël Luciano Tantely
    Universite Montpellier 2, UMR CNRS 5554, Institut des Sciences de l Evolution, Génétique de l Adaptation, Place Eugene Bataillon, Montpellier 05, France
    Insect Biochem Mol Biol 40:317-24. 2010
    ..Rdl selection in these two mosquito species discloses current insecticide pressures in urban areas, from unknown origins, that should be taken into account to develop vector control strategies...
  33. ncbi Mechanisms of altered vagal control in heart failure: influence of muscarinic receptors and acetylcholinesterase activity
    Mark E Dunlap
    Department of Medicine Cardiology, Louis Stokes Cleveland Veterans Affairs Medical Center, Medical Research Service 151W, 10701 East Blvd, Cleveland, OH 44106, USA
    Am J Physiol Heart Circ Physiol 285:H1632-40. 2003
    ..To investigate possible mechanisms, we measured muscarinic receptor density (Bmax) and acetylcholinesterase activity in different areas of the heart...
  34. ncbi Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies
    Kornkanok Ingkaninan
    Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    J Ethnopharmacol 89:261-4. 2003
    b>Acetylcholinesterase (AChE) inhibitor has been used as a drug for the symptomatic treatment of Alzheimer's disease...
  35. pmc Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations
    Philippe Menozzi
    Groupe de biotechnologie des protéines, IPBS UMR 5089, F 31077 Toulouse, France
    BMC Evol Biol 4:4. 2004
    Organophosphate and carbamate insecticides irreversibly inhibit acetylcholinesterase causing death of insects...
  36. ncbi Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones
    L R Fodero
    Department of Pathology, University of Melbourne, Parkville, Australia
    J Neurochem 88:1186-93. 2004
    ..Although there is a loss of acetylcholinesterase (AChE) from both cholinergic and non-cholinergic neurones in the brain of Alzheimer patients, the level of ..
  37. ncbi Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies
    M Shapira
    Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Givat Ram
    J Mol Neurosci 17:1-12. 2001
    ..Because acetylcholinesterase (AChE) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we ..
  38. pmc Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica
    Yutthapong Sangnoi
    Department of Industrial Biotechnology, Faculty of Agro Industry, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand
    Mar Drugs 6:578-86. 2008
    b>Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from a novel species of a marine gliding bacterium Rapidithrix thailandica, was assessed (IC(50) 4.9 microM)...
  39. ncbi Pollutant-induced alterations of granulocyte morphology in the earthworm Eisenia foetida
    Antonio Calisi
    Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita del Salento, Via provinciale Lecce Monteroni, Lecce, Italy
    Ecotoxicol Environ Saf 72:1369-77. 2009
    ..a battery of standardized biomarkers such as lysosomal membrane stability, metallothionein induction, or acetylcholinesterase (AChE) inhibition were also determined...
  40. ncbi Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke
    Gustavo Roberto Thomé
    Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria RS, Brazil
    Nicotine Tob Res 13:1210-9. 2011
    ..The aim of the present study was to evaluate the effect of vitamin E on acetylcholinesterase (AChE) activity and the lipid peroxidation level in the brain of rats in the model of exposure to aged and ..
  41. pmc Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum
    Yanhui Lu
    Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506 4004, USA
    Sci Rep 2:288. 2012
    We compared biological functions of two acetylcholinesterase genes (TcAce1 and TcAce2) in Tribolium castaneum, a globally distributed major pest of stored grain products and an emerging model organism, by using RNA interference...
  42. ncbi Mutations of acetylcholinesterase which confer insecticide resistance in insect populations
    D Fournier
    IPBS, Biotechnologie des Proteines, 205 route de Narbonne, 31077 Toulouse, France
    Chem Biol Interact 157:257-61. 2005
    ..Natural populations are heterogeneous, composed of a mixture of different alleles...
  43. pmc Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1
    Laura E Sperling
    Entwicklungsbiologie und Neurogenetik, Fachbereich Biologie, Technische Universitat Darmstadt, Darmstadt, Germany
    PLoS ONE 7:e36683. 2012
    The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as ..
  44. ncbi Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons
    J W Bigbee
    Department of Anatomy, Medical College of Virginia School of Medicine, Virginia Commonwealth University, P O Box 980709, Richmond, VA 23298 0709, USA
    Brain Res 861:354-62. 2000
    Dorsal root ganglion (DRG) neurons show a transient peak expression of acetylcholinesterase (AChE) during periods of axonal outgrowth prior to synaptogenesis, suggesting that AChE has a non-enzymatic role during development...
  45. ncbi Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats
    Tranum Kaur
    Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Brain Cogn 67:25-30. 2008
    ..To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats...
  46. ncbi Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology
    Israel Silman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Pharmacol 5:293-302. 2005
    The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine...
  47. ncbi Virtues and woes of AChE alternative splicing in stress-related neuropathologies
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Building 41, 41 Library Drive, Bethesda, MD 20892, USA
    Trends Neurosci 29:216-24. 2006
    The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing...
  48. ncbi Biochemical and molecular characterisation of acetylcholinesterase in four field populations of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)
    Guang Mao Shen
    Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, PR China
    Pest Manag Sci 68:1553-63. 2012
    ..dorsalis from mainland China has identified high levels of resistance to insecticides. In this study, the biochemical and molecular characteristics of acetylcholinesterase (AChE) in four field populations of B. dorsalis are investigated.
  49. ncbi Acetylcholinesterase. Two types of modifications confer resistance to insecticide
    D Fournier
    Centre de recherche d Antibes, Laboratoire de Biologie des Invertébrés, France
    J Biol Chem 267:14270-4. 1992
    Quantitative and qualitative changes in acetylcholinesterase confer resistance to insecticides. We have constructed several Drosophila melanogaster strains producing various amounts of enzyme by P-mediated transformation...
  50. ncbi Structures of human acetylcholinesterase in complex with pharmacologically important ligands
    Jonah Cheung
    New York Structural Biology Center, New York, New York 10027, USA
    J Med Chem 55:10282-6. 2012
    Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs...
  51. pmc Cortical cholinergic abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat
    Steven Anzalone
    Department of Psychology, Behavioral Neuroscience Program, State University of New York at Binghamton, Binghamton, NY 13902, USA
    Eur J Neurosci 32:847-58. 2010
    ..Specifically, some frontal cortical regions exhibit hypersensitivity to deafferentation that is only detected during behavioral and/or physiological demand...
  52. ncbi Insecticide resistance: a silent base prediction
    Mylene Weill
    Curr Biol 14:R552-3. 2004
  53. ncbi In vivo toxic and lethal cardiovascular effects of a synthetic polymeric 1,3-dodecylpyridinium salt in rodents
    Marjana Grandič
    Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia
    Toxicol Appl Pharmacol 255:86-93. 2011
    ..However, acute lesions were observed in the pulmonary vessels of rats after application of 8mg/kg APS12-2. Predominant effects were dilation of interalveolar blood vessels and lysis of aggregated erythrocytes within their lumina...
  54. pmc Pre-invasion history and demography shape the genetic variation in the insecticide resistance-related acetylcholinesterase 2 gene in the invasive Colorado potato beetle
    Saija Piiroinen
    Centre of Excellence in Biological Interactions Research, Department of Biological and Environmental Science, University of Jyvaskyla, P O Box 35, FI 40014, Jyvaskyla, Finland
    BMC Evol Biol 13:13. 2013
    ..native and invasive beetle populations, we studied the origins of organophosphate (OP) resistance-associated mutations in the acetylcholinesterase 2 (AChE2) gene, and the role of selection and demography on its genetic variability.
  55. ncbi Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae)
    I V Coutinho-Abreu
    Laboratorio de Genetica Molecular Humana, Departamento de Genetica, UFPE, Recife PE, Brazil
    J Med Entomol 44:639-50. 2007
    b>Acetylcholinesterase (AChE) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides...
  56. ncbi Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization
    Yingjun Zhao
    Shanghai Medical College, Fudan University, Shanghai, China
    Hepatology 53:493-503. 2011
    b>Acetylcholinesterase (ACHE) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. However, the roles and implications of ACHE in hepatocellular carcinoma (HCC) remain elusive...
  57. ncbi Targeting acetylcholinesterase to treat neurodegeneration
    Ulrike Holzgrabe
    Institute of Pharmacy and Food Chemistry, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Expert Opin Ther Targets 11:161-79. 2007
    ..treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (AChE), the latter being able to increase the concentration of acetylcholine...
  58. ncbi Integrated use of biomarkers (acetylcholinesterase and antioxidant enzymes activities) in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine area
    M G Lionetto
    Lab di Fisiologia Generale ed Ambientale, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita di Lecce, via prov le Lecce Monteroni, Italy
    Mar Pollut Bull 46:324-30. 2003
    ..The aim of the present work was the field application of the integrated use of acetylcholinesterase (AChE) and antioxidant enzymes (catalase--CAT, glutathione peroxidase--GSH-Px), for detecting the possible ..
  59. ncbi Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments
    O Cohen
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
    Mol Psychiatry 7:874-85. 2002
    ..were explored in behaviorally impaired transgenic (Tg) FVB/N mice expressing synaptic human acetylcholinesterase (hAChE-S)...
  60. ncbi Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.)
    Stefano Cassanelli
    Department of Agricultural Science, University of Modena and Reggio Emilia, Reggio Emilia, Via JFK Kennedy 17 19, RE 42100, Italy
    Insect Biochem Mol Biol 36:642-53. 2006
    ..In the Raz strain, a target site resistance mechanism was suggested by the inhibition of acetylcholinesterase (AChE) activity...
  61. ncbi Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations
    Haoues Alout
    Team Genomic of Adaptation, CNRS UMR 5554, Institut des Sciences de l Evolution, C C 065, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier, France
    Insect Biochem Mol Biol 39:884-91. 2009
    Two amino acid substitutions in acetylcholinesterase 1 (AChE1), G119S and F290V, are responsible for resistance to organophosphate and carbamate insecticides in Culex pipiens mosquitoes...
  62. pmc Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunit
    Alexandre Dobbertin
    Universite Paris Descartes, Paris, France
    J Neurosci 29:4519-30. 2009
    b>Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA)...
  63. ncbi Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Krøyer)
    Anders Fallang
    The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Pest Manag Sci 60:1163-70. 2004
    b>Acetylcholinesterase (AChE) is the target of a major pesticide family, the organophosphates, which were extensively used as control agents of sea lice on farmed salmonids in the early 1990s...
  64. ncbi Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity
    Magdalini A Papandreou
    Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Greece
    Behav Brain Res 198:352-8. 2009
    ..PrB30) and 60 (PrB60) mg/kg body weight for 7 days, on cognitive performance, brain oxidative status and acetylcholinesterase activity in adult, male, 3-4-month-old Balb-c mice...
  65. ncbi Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease
    Liat BenMoyal-Segal
    The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
    FASEB J 19:452-4. 2005
    ..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
  66. ncbi Berberine: a potential multipotent natural product to combat Alzheimer's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Molecules 16:6732-40. 2011
    ..In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and ..
  67. ncbi Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia
    C Perry
    Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leukemia 21:1472-80. 2007
    Hematological changes induced by various stress stimuli are accompanied by replacement of the primary acetylcholinesterase (AChE) 3' splice variant acetylcholinesterase-S (AChE-S) with the myelopoietic acetylcholinesterase-R (AChE-R) ..
  68. ncbi The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation
    Varda R Deutsch
    Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Exp Hematol 30:1153-61. 2002
    ..b>Acetylcholinesterase (AChE) is expressed in mammalian neurons and hematopoietic cells...
  69. ncbi Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata
    Pradeep Kumar
    Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India
    Phytother Res 23:172-7. 2009
    ..Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata...
  70. ncbi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Biol Pharm Bull 32:1433-8. 2009
    ..Coptidis Rhizoma were evaluated via beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) assays, along with peroxynitrite (ONOO(-)) scavenging and total ..
  71. ncbi Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
  72. ncbi Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase
    Dong Liang
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    J Biol Chem 284:5195-207. 2009
    The mammalian protein CutA was first discovered in a search for the membrane anchor of mammalian brain acetylcholinesterase (AChE). It was co-purified with AChE, but it is distinct from the real transmembrane anchor protein, PRiMA...
  73. ncbi High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
    K Ingkaninan
    Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
    J Chromatogr A 872:61-73. 2000
    ..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
  74. pmc Differential localization of acetylcholinesterase in neuronal and non-neuronal cells
    Matthew D Thullbery
    Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    J Cell Biochem 96:599-610. 2005
    b>Acetylcholinesterase (AChE) expression is regulated in cell types at the transcriptional and translational levels...
  75. ncbi Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
    M F Frasco
    IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
    Biomarkers 10:360-75. 2005
    The enzymatic activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
  76. ncbi A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation
    G V De Ferrari
    Center for Cell Regulation and Pathology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic University of Chile and Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
    Biochemistry 40:10447-57. 2001
    b>Acetylcholinesterase (AChE) has been found to be associated with the core of senile plaques...
  77. pmc ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities
    D Grisaru
    Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
    Mol Med 7:93-105. 2001
    ..Here we report the involvement of the stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, and its 26 amino acid C-terminal domain (ARP) in hematopoietic stress responses...
  78. ncbi Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
    Marco Giorgetti
    Medivation, Inc, San Francisco, California 94105, USA
    J Pharmacol Exp Ther 333:748-57. 2010
    ..Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and the N-methyl-d-aspartate (NMDA) receptor, the low in vitro affinity for these targets suggests ..
  79. pmc Structural insights into substrate traffic and inhibition in acetylcholinesterase
    Jacques Philippe Colletier
    Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale CEA CNRS UJF, Grenoble Cedex, France
    EMBO J 25:2746-56. 2006
    b>Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine...
  80. ncbi Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
    Martina Zimmermann
    Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 90:1489-99. 2004
    b>Acetylcholinesterase inhibitors (AChEIs) are the only currently available drugs for treating Alzheimer's Disease (AD)...
  81. ncbi Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds
    Pelayo Camps
    Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Med Chem 52:5365-79. 2009
    Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) ..
  82. ncbi Insecticide resistance in the malarial mosquito Anopheles arabiensis and association with the kdr mutation
    T S Matambo
    Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Sandringham, Johannesburg, South Africa
    Med Vet Entomol 21:97-102. 2007
    ..The implications for malaria vector control in central Sudan are serious and resistance management (e.g. through the rotational use of different classes of insecticides) is recommended...
  83. ncbi Characterization of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae (Diptera: Culicidae): resistance levels and dominance
    L Djogbenou
    Institut de Recherche pour le Développement UR016, IRD CREC, 01 BP 4414 RP, Cotonou, Republic of Benin
    J Med Entomol 44:805-10. 2007
    ..Resistance and dominance levels conferred by the G119S mutation of acetylcholinesterase (ace-1R) of the mosquito Anopheles gambiae s.s...
  84. ncbi Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission
    Gabriel Zimmerman
    The Institute of Life Sciences and the Interdisciplinary Center for Neural Computation ICNC, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Cell Tissue Res 326:655-69. 2006
    ..This unique termination mechanism makes acetylcholinesterase (AChE), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling...
  85. ncbi Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  86. ncbi Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia
    V T Nguyen
    Department of Dermatology, University of California Davis, UC Davis Medical Center, Sacramento 95817, USA
    J Dent Res 79:939-49. 2000
    ..alpha7, and beta2 nAChR subunits, choline acetyltransferase, and the asymmetric and globular forms of acetylcholinesterase were amplified from gingival keratinocytes (KC) by means of polymerase chain-reactions...
  87. ncbi Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation
    I Nijholt
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Mol Psychiatry 9:174-83. 2004
    ..neurophysiological and behavioral findings attributing much of this effect to alternative splicing of the acetylcholinesterase (AChE) gene in hippocampal neurons...
  88. ncbi An acetylcholinesterase purified from the greenbug (Schizaphis graminum) with some unique enzymological and pharmacological characteristics
    J R Gao
    Department of Entomology, 123 Waters Hall, Kansas State University, Manhattan, KS 66506, USA
    Insect Biochem Mol Biol 31:1095-104. 2001
    An acetylcholinesterase (AChE, EC 3.1.1.7) was purified from the greenbug, Schizaphis graminum (Rondani)...
  89. ncbi Biological monitoring of exposure to pesticides: current issues
    F He
    Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, P R China
    Toxicol Lett 108:277-83. 1999
    ..This paper provides an overview on the research strategies and application of biological monitoring of pesticide exposure...
  90. pmc Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase
    K Tai
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Biophys J 81:715-24. 2001
    A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with special attention paid to the fluctuation in the width of the gorge and opening events of the back door...
  91. pmc Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides
    Yuan Ping Pang
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 4:e4349. 2009
    ..are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE)...
  92. ncbi Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    M M Mesulam
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 110:627-39. 2002
    b>Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways...
  93. ncbi Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis
    R Deng
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Oncogene 25:7070-7. 2006
    It has been shown that acetylcholinesterase (AChE) expression was induced during apoptosis and the anti-sense oligonucleotides and siRNA of AChE may prevent apoptosis in various cell types...
  94. ncbi Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors
    Afrim H Bytyqi
    Darmstadt University of Technology, Developmental Biology and Neurogenetics, D 64287 Darmstadt, Germany
    Eur J Neurosci 20:2953-62. 2004
    ..As an alternative, we show here for an acetylcholinesterase (AChE) knockout mouse that photoreceptor degeneration follows an impaired development of the inner retina...
  95. ncbi Acetylcholinesterase in cell adhesion, neurite growth and network formation
    Laura E Paraoanu
    Darmstadt University of Technology, Germany
    FEBS J 275:618-24. 2008
    The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative ..
  96. ncbi Molecular and biochemical characterization of a sand fly population from Sri Lanka: evidence for insecticide resistance due to altered esterases and insensitive acetylcholinesterase
    S N Surendran
    Department of Zoology, University of Jaffna, Jaffna, Sri Lanka
    Bull Entomol Res 95:371-80. 2005
    ..Island collection was assayed for the activities of four enzyme systems involved in insecticide resistance (acetylcholinesterase, non-specific carboxylesterases, glutathione-S-transferases and cytochrome p450 monooxygenases), ..
  97. pmc Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
    Klara R Birikh
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Proc Natl Acad Sci U S A 100:283-8. 2003
    ..Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein ..
  98. pmc N-acetylcholinesterase-induced apoptosis in Alzheimer's disease
    Debra Toiber
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 3:e3108. 2008
    ..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.
  99. ncbi Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    H Shimada
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
    Neurology 73:273-8. 2009
    ..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
  100. pmc Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'Ivoire
    Ludovic P Ahoua Alou
    Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
    Malar J 9:167. 2010
    ..It is, therefore, essential to investigate on the susceptibility of pyrethroid resistant populations of An. gambiae s.s. to these alternative products...
  101. ncbi Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to organophosphorus insecticides
    Ju Chun Hsu
    Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Council of Agriculture, 11 Kuang Ming Road, Wufeng 413, Taichung Hsien, Taiwan
    Insect Biochem Mol Biol 36:396-402. 2006
    Mutations in the gene encoding the enzyme acetylcholinesterase (AChE) of the oriental fruit fly, Bactrocera dorsalis, associated with resistance to an organophosphorus insecticide have been characterized...

Research Grants70

  1. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..Their toxicity is principally due to their ability to irreversibly bind to acetylcholinesterase (AChE) in the CNS and blood...
  2. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..CTAs exert their toxic effects by inhibiting acetylcholinesterase (AChE) leading to the accumulation of acetylcholine at synaptic and neuromuscular junctions leading to ..
  3. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our continuing investigation of acetylcholinesterase (AChE), the acetylcholine binding protein (AChBP) reflect a long standing and continuous commitment to the study of proteins that affect the ..
  4. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..molecules include glycoproteins such as the neural cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids such as the receptor for cholera toxin, components of the cell walls of bacteria and yeast, ..
  5. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    ..Mammalian brain contains two forms of cholinesterase, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)...
  6. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..Cholinesterase inhibitors such as tacrine increase synaptic levels of ACh by preventing its inactivation by acetylcholinesterase (AChE) or butyrylcholinesterase (BuChE), and can improve learning and memory...
  7. Repurposing cholinesterase inhibitors for smoking cessation
    REBECCA ASHARE; Fiscal Year: 2013
    ..designed to examine the effects on smoking cessation of a novel pharmacological treatment, galantamine, an acetylcholinesterase inhibitor (ACHEI) that is FDA-approved to treat the cognitive symptoms of Alzheimer's disease...
  8. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
  9. Congenital Myasthenic Syndromes: Pathogenic Mechanisms
    RICARDO ANIBAL MASELLI; Fiscal Year: 2013
    ..encoding the adult acetylcholine receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
  10. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
  11. Mechanisms of nicotine-induced neuroplasticity
    Katumi Sumikawa; Fiscal Year: 2013
    ..The effect of nicotine on NMDAR is mimicked by anti-acetylcholinesterase drugs for Alzheimer's disease and prevented by coadministration of a muscarinic receptor antagonist...
  12. Protection against sarin-induced neurotoxicity via an in vivo caspase inhibitor
    David R Cool; Fiscal Year: 2011
    ..for CWA organophosphate exposure is a specialized drug combination containing;a drug to regenerate acetylcholinesterase activity;and two drugs to prevent seizures...
  13. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  14. Central cholinergic regulation of inflammation
    VALENTIN ATANASSOV PAVLOV; Fiscal Year: 2013
    ..We have also recently shown that galantamine, a centrally-acting acetylcholinesterase (AChE) inhibitor suppresses systemic TNF levels and improves survival in endotoxemia through brain ..
  15. Structural Analysis of the GPI Transamidase Complex
    Anant K Menon; Fiscal Year: 2012
    ..Examples of GPI-APs include folate receptor, acetylcholinesterase, renal dipeptidase and the variant surface glycoproteins of Trypanosoma brucei, the causative agent of ..
  16. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..These compounds inhibit the enzymes acetylcholinesterase (AChE) and butylrylcholinesterase (BChE)...
  17. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2012
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  18. Augmentation of Parasympathetic Signaling with Pyridostigmine in Heart Failure
    Stuart D Katz; Fiscal Year: 2013
    ..b>Acetylcholinesterase inhibitors augment parasympathetic neurotransmission by blocking the enzymatic breakdown of acetylcholine ..
  19. Improved standard of care reactivaters and facilitative transport into the centra
    GREGORY EDWARD GARCIA; Fiscal Year: 2013
    ..the current standard of care (SOC) therapies (United States) of acetylcholine receptor blocker atropine, acetylcholinesterase (AChE) reactivator pralidoxime (2-[(hydroxyimino)methyl]-1-methylpyridinium, 2-PAM), and symptom modulator ..
  20. Organophosphate Action in the Central Nervous System
    NEIL MARC NATHANSON; Fiscal Year: 2012
    Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
  21. A tale of two synapses: The development of neurotransmitter phenotype in motor ne
    Melissa A Harrington; Fiscal Year: 2013
    ..and investigate how contact with muscle cells, the formation of neuromuscular junctions, and possibly acetylcholinesterase influence the neurotransmitter released...
  22. Neonatal Methamphetamine Effects on Adult Cholinergic and Cognitive Function
    Jessica A Siegel; Fiscal Year: 2010
    ..in adulthood using muscarinic acetylcholine receptor binding assays;and 3) determine the ability of the acetylcholinesterase inhibitor rivastigmine or the muscarinic receptor agonist carbachol, injected directly into the lateral ..
  23. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal if untreated...
  24. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..agents used as agents of terror include organophosphorus (OP) compounds, neurotoxic substances that inhibit acetylcholinesterase (AChE) activity. When the neurotransmitter acetylcholine is not destroyed cholinergic poisoning can result...
  25. "Development of Drugs to Mitigate Parathion Intoxication"
    Jeffrey D Laskin; Fiscal Year: 2012
    ..A major site of action for paraoxon is the enzyme acetylcholinesterase;proper functioning of this enzyme is crucial for normal nerve cell activity and its inhibition can be fatal...
  26. Pharmacotherapy to counterACT parathion-induced NMJ dysfunction
    Steven B Bird; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  27. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  28. CutA interacts with BACE1 and participates in Alzheimer's disease
    Yunwu Zhang; Fiscal Year: 2012
    ..Previous studies suggest that CutA may regulate the level/activity of acetylcholinesterase (AChE), an enzyme that degrades acetylcholine and an important target of inhibition for current AD ..
  29. PET Imaging Agents for a4b2 Nicotinic Receptors
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..This will be of great value to evaluate efficacy of acetylcholinesterase inhibitors used in AD...
  30. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  31. Asthma Exacerbation by Organophosphate Pesticides
    ALLISON DEBORAH FRYER; Fiscal Year: 2011
    ..that normally limit acetylcholine release, and occurs at doses significantly lower than those that inhibit acetylcholinesterase. Here we show that sensitized animals (sensitized to an antigen but never challenged with antigen) are ..
  32. Counteracting acute and persistent effects of OP intoxication by endocannabinoids
    Carey N Pope; Fiscal Year: 2011
    ..While substantial evidence indicates that non-cholinergic signaling is "recruited" following acetylcholinesterase inhibition and plays a role in long-term neurological deficits, involvement of other signaling pathways is ..
  33. Induced Therapeutic Overexpression of Acetylcholinesterase in Vivo
    RICHARD LEE ROTUNDO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetylcholinesterase (AChE), the enzyme that terminates cholinergic transmission in the nervous system, is the target of organophosphate nerve agents and pesticides...
  34. Donepezil to promote functional recovery post-stroke
    Ellen M Whyte; Fiscal Year: 2013
    ..Recent evidence indicates that acetylcholinesterase inhibitors may improve cognition and motivation;hence, their use post-stroke may lead to improved ..
  35. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ..Levels of choline acetyltransferase and acetylcholinesterase activities in the hippocampus and frontal cortex also will be measured as indices of the degree of ..
  36. The neurogenic potential of cholinergic activation in AD.
    ELIZABETH ADAMS ECKMAN; Fiscal Year: 2013
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  37. Environmental Enrichment and Cholinergic Mechanisms after TBI
    Anthony E Kline; Fiscal Year: 2013
    ..assess the effect of a delayed and chronic treatment regimen (1-20 days post-injury) with the FDA-approved acetylcholinesterase inhibitor donepezil in male and both intact and OVX female rats after TBI to determine if motor and ..
  38. A Phase II Trial of Rituximab In Myasthenia Gravis
    Richard Nowak; Fiscal Year: 2013
    ..Treatment consists of symptomatic therapy with acetylcholinesterase inhibitors and immunotherapy such as corticosteroids, azathioprine, cyclosporine, and plasma exchange (PLEX)..
  39. Synthesis of methylating ligands that reactivate aged acetylcholinesterase
    DANIEL M QUINN; Fiscal Year: 2012
    ..such as sarin and soman, are acutely toxic compounds that act by inhibiting the activity of the enzyme acetylcholinesterase (AChE) at nerve-nerve and neuromuscular junctions in the central and peripheral nervous systems, ..
  40. Rivastigmine and Huperzine A as Potential Treatments for Cocaine Addiction
    Richard De La Garza; Fiscal Year: 2012
    ..shown the importance of muscarinic ACh receptors in cocaine reinforced- and non-reinforced-responding, and acetylcholinesterase (AChE) inhibitors reduced methamphetamine-seeking behavior in rodents...
  41. Developing Drugs to Mitigate Parathion Intoxication
    Jason R Richardson; Fiscal Year: 2013
    ..We have further demonstrated that our drug is effective in reducing parathion-induced inhibition of brain acetylcholinesterase activity...
  42. Cholinergic Enhancement as Treatment for Nicotine Addiction
    Andrew J Waters; Fiscal Year: 2013
    ..GAL enhances cholinergic transmission by inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine...
  43. Investigations Targeting Symptomatic Relief to Botulinum Neurotoxin A Intoxicatio
    Kim D Janda; Fiscal Year: 2013
    ..when administered will promote acetylcholine release and ones that will promote both acetylcholine release/acetylcholinesterase inhibition, in other words poly-functional intervention...
  44. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
  45. ACETYLCHOLINESTERASE-CATALYZED HYDROLYSIS
    Daniel Quinn; Fiscal Year: 1991
    b>Acetylcholinesterase (AChE) is an enzyme with rich biomedical, pharmacological and toxicological history. This is undoubtedly due to the central role tat AChE plays, along with the ACh receptor, in cholinergic neurotransmission...
  46. Rivastigmine as a Treatment for Methamphetamine Dependence
    Richard De La Garza; Fiscal Year: 2010
    ..a double-blind placebocontrolled human laboratory study demonstrating that treatment with a 3mg dose of the acetylcholinesterase (AChE) inhibitor rivastigmine significantly attenuated MA-induced craving...
  47. Cognitive Neurorehabilitation to Enhance Recovery After Stroke
    DeAnna L Adkins; Fiscal Year: 2010
    ..the hippocampus compared to non-trained groups;3) Coupling cognitive neurorehabilitative training with an acetylcholinesterase inhibitor will enhance the efficacy of post-stroke cognitive neurorehabilitation...
  48. Modeling cholinergic modulation of fMRI memory networks in aging & MCI
    Alireza Atri; Fiscal Year: 2010
    ..b>Acetylcholinesterase inhibitors (AChEl) produce modest overall benefits in AD but their effects in MCI are less clear...
  49. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
  50. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2001
    ..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
  51. NEW MUSCARINIC AGENTS--SELECTIVITY OF ACTION
    Frank Carroll; Fiscal Year: 1990
    ..g., arecoline) or indirectly by inhibition of acetylcholinesterase (AChE) (e.g., physostigmine) can enhance performance...
  52. Genetic Resource for Assaying Neuropeptide Function in vivo
    AMY BETH VASHLISHAN MURRAY; Fiscal Year: 2012
    ..both endogenous and ectopically expressed neuropeptides in response to muscle contraction induced by the acetylcholinesterase inhibitor aldicarb...
  53. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..Administration of selective inhibitors of acetylcholinesterase like donepezil (Aricept) has proven effective in improving neurocognitive functioning and behavioral ..
  54. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  55. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
    ..atropine combination therapy is inefficient for treatment of higher exposure OP poisoning due to constant acetylcholinesterase (AChE) reinhibition by excess OP...
  56. NEUROMODULATOR INFLUENCES ON PREFRONTAL CORTICAL FUNCTION
    Christos Constantinidis; Fiscal Year: 2013
    ..Cholinergic drugs (acetylcholine agonists and acetylcholinesterase inhibitors) can reverse these symptoms...
  57. Fetal Alcohol Effects and Choline Intervention
    Jennifer D Thomas; Fiscal Year: 2013
    ..Secondly, we will examine whether administration of donepezil, an acetylcholinesterase inhibitor which also increases cholinergic activity, can improve cognitive performance following early ..
  58. A NEW BIOSENSOR BASED ON CATASTROPHIC PROTEIN CHANGES
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..This concept will be tested and proven using recombinant acetylcholinesterase (AChE) an enzyme that is known to undergo catastrophic denaturation when it reacts with organophosphate (OP)..
  59. PHYSIOLOGIC RESPONSE TO THERMAL INJURY
    EDWARD PAVLIN; Fiscal Year: 1990
    ..3) Acetylcholinesterase activity at the NMJ is decreased allowing ACh to be increased relative to its competitive antagonist NDMR...
  60. Enhanced bioscavenger for medical countermeasures against organophosphorus agents
    Zhiguo Zhou; Fiscal Year: 2013
    ..OP's act on acetylcholinesterase to prevent synaptic inactivation, thereby leading to immobilization and death on sustained application...
  61. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1992
    ..cholinergic systems will be assessed by histological and morphometric analysis after staining cultures for acetylcholinesterase activity (AChE) and choline acetyltransferase (CHAT) - immunoreactivity, and by biochemical analysis of ..
  62. C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2012
    ..This method will enable rapid access to the recently isolated acetylcholinesterase inhibitor lycojapodine A...
  63. Olfactory deficits and donepezil treatment in cognitively impaired elderly
    Davangere P Devanand; Fiscal Year: 2013
    ..b>Acetylcholinesterase inhibitors (ACheI) like donepezil show modest effects in improving cognition but can be associated with ..
  64. Neurological Outcomes Among Pesticide Applicators
    Fredric Gerr; Fiscal Year: 2009
    b>Acetylcholinesterase inhibiting pesticides (i.e., organophosphate (OP) and carbamate pesticides) are widely used in the US and worldwide...
  65. C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2013
    ..This method will enable rapid access to the recently isolated acetylcholinesterase inhibitor lycojapodine A...
  66. NEURAL & PHARMACOLOGICAL CONTROL OF AIRWAY SMOOTH MUSCLE
    Richard Mitchell; Fiscal Year: 1991
    ..could be mimicked in muscle strips by addition of small concentrations of acetylcholine or by inhibiting acetylcholinesterase. These studies indicated possible presynaptic augmentation of acetylcholine release and/or reduced ..
  67. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
  68. Metabolism and Age-Related Organophosphate Toxicity
    Janice Chambers; Fiscal Year: 2005
    ..of hepatic and blood detoxication mechanisms (the protective esterases: carboxylesterases, non-target acetylcholinesterase, butyrylcholinesterase, A-esterase) and target enzyme (brain and peripheral acetylcholinesterase) ..
  69. STUDIES OF MEGAKARYOCYTOPOIESIS
    Samuel Burstein; Fiscal Year: 1991
    ..extracts of spleen cells on the proliferation of an IL-3-dependent cell line and on the synthesis of acetylcholinesterase in liquid marrow cultures...
  70. SALIVARY GLANDS AND THEIR INNERVATION IN DIABETES
    JACOB HANKER; Fiscal Year: 1980
    ..The secretory activity of the salivary glands, regulated by acetylcholinesterase-positive parasympathetic fibers from branches of the fifth, seventh, ninth and tenth cranial nerves, will ..