Genomes and Genes
Summary: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 188.8.131.52.
Publications316 found, 100 shown here
- Acetylcholinesterase--new roles for an old actorH Soreq
Nat Rev Neurosci 2:294-302. 2001..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
- MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesteraseIftach Shaked
Department of Biological Chemistry, The Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Immunity 31:965-73. 2009..inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation...
- Comparative genomics: Insecticide resistance in mosquito vectorsMylene Weill
Institut des Sciences de l Evolution, UMR 5554, CC 065, Universite Montpellier II, 34095 Montpellier, France
Nature 423:136-7. 2003
- Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetleYanhui Lu
Department of Entomology, China Agricultural University, Beijing, People s Republic of China
PLoS ONE 7:e32288. 2012Since the report of a paralogous acetylcholinesterase (AChE, EC184.108.40.206) gene in the greenbug (Schizaphis graminum) in 2002, two different AChE genes (Ace1 and Ace2) have been identified in each of at least 27 insect species...
- Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseasesYuan Ping Pang
Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 4:e6851. 2009..We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish...
- SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNAE Meshorer
Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Mol Psychiatry 10:985-97. 2005Long-lasting alternative splicing of neuronal acetylcholinesterase (AChE) pre-mRNA occurs during neuronal development and following stress, altering synaptic properties...
- Induction of acetylcholinesterase expression during apoptosis in various cell typesX J Zhang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Cell Death Differ 9:790-800. 2002b>Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission...
- A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stressRinat Kehat
Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and the Rappaport Institute, Haifa, Israel
Invest Ophthalmol Vis Sci 48:1290-7. 2007To study the involvement of stress-induced acetylcholinesterase (AChE) expression in light-induced retinal damage in albino rats.
- Molecular, biochemical and histochemical characterization of two acetylcholinesterase cDNAs from the German cockroach Blattella germanicaJ I Kim
School of Agricultural Biotechnology, Seoul National University, Seoul, Korea
Insect Mol Biol 15:513-22. 2006..Bgace2 transcript is found only in the subset of neurones, particularly in the cell body. In addition, certain neurones were observed to express Bgace1 only...
- Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiaeHaobo Jiang
Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
Insect Biochem Mol Biol 39:646-53. 2009..Furthermore, we found that choline inhibited r-AgAChE1, a phenomenon related to the enzyme activity decrease at high concentrations of acetylcholine...
- Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiationI Nijholt
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
Mol Psychiatry 9:174-83. 2004..neurophysiological and behavioral findings attributing much of this effect to alternative splicing of the acetylcholinesterase (AChE) gene in hippocampal neurons...
- Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee coloniesM Shapira
Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Givat Ram
J Mol Neurosci 17:1-12. 2001..Because acetylcholinesterase (AChE) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we ..
- Expression and localization of acetylcholinesterase at the neuromuscular junctionRichard L Rotundo
Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
J Neurocytol 32:743-66. 2003b>Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ)...
- Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neuronsHeidi Q Xie
Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong
J Biol Chem 285:11537-46. 2010In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor)...
- Treatment of human myasthenia gravis with oral antisense suppression of acetylcholinesteraseZ Argov
Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Neurology 69:699-700. 2007
- Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa)K R Dabire
Institut de Recherche en Sciences de la Santé Centre Muraz, Bobo Dioulasso, Burkina Faso
Trop Med Int Health 14:396-403. 2009..at 20 localities across the three different agro-climatic zones of Burkina Faso, the distribution of the acetylcholinesterase insensitive mutation ace-1(R), which confers resistance to organophosphates (OP) and carbamates (CM) ..
- PRiMA: the membrane anchor of acetylcholinesterase in the brainAnselme L Perrier
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Neuron 33:275-85. 2002As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
- Silencing of acetylcholinesterase gene of Helicoverpa armigera by siRNA affects larval growth and its life cycleManeesh Kumar
Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India
J Insect Physiol 55:273-8. 2009..We studied the effect of siRNA on larval development by selective targeting of the acetylcholinesterase (AChE) gene of Helicoverpa armigera. Chemically synthesized siRNA molecules were directly fed to H...
- An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicaeTakeshi Nabeshima
Laboratory of Applied Zoology E407, Department of Agriculture and Forestry, Institute of Agriculture and Forestry, University of Tsukuba, Tennodai 1 1 1, Ibaraki, 305 8572, Japan
Biochem Biophys Res Commun 307:15-22. 2003..However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains. This substitution was located in the acyl pocket of the enzyme and was thought to alter the ligand specificity...
- Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathologyAmit Berson
The Eric Roland Center for Neurodegenerative Diseases, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Brain 131:109-19. 2008..One known link involves synaptic acetylcholinesterase (AChE-S), shown to accelerate amyloid fibrils formation...
- Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesteraseR N'Guessan
Centre Pierre Richet, Institut National Santé Publique, Bouake, Cote d Ivoire, France
Med Vet Entomol 17:19-25. 2003..Our study demonstrates the need to monitor carbamate resistance among populations of the An. gambiae complex in Africa, to determine its spread and anticipate vector control failure if these insecticides are employed...
- Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitizationYingjun Zhao
Shanghai Medical College, Fudan University, Shanghai, China
Hepatology 53:493-503. 2011b>Acetylcholinesterase (ACHE) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. However, the roles and implications of ACHE in hepatocellular carcinoma (HCC) remain elusive...
- Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae)I V Coutinho-Abreu
Laboratorio de Genetica Molecular Humana, Departamento de Genetica, UFPE, Recife PE, Brazil
J Med Entomol 44:639-50. 2007b>Acetylcholinesterase (AChE) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides...
- Ace-1 duplication in Anopheles gambiae: a challenge for malaria controlLuc Djogbenou
Institut de Recherche pour le Developpement, UR 016, Cotonou, Benin
Malar J 8:70. 2009..malaria, resistance to organophosphates and carbamates is mainly due to a single amino-acid substitution in acetylcholinesterase 1 (AChE1). This mutation entails a large fitness cost...
- Targeting acetylcholinesterase to treat neurodegenerationUlrike Holzgrabe
Institute of Pharmacy and Food Chemistry, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
Expert Opin Ther Targets 11:161-79. 2007..treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (AChE), the latter being able to increase the concentration of acetylcholine...
- Targeting of acetylcholinesterase in neurons in vivo: a dual processing function for the proline-rich membrane anchor subunit and the attachment domain on the catalytic subunitAlexandre Dobbertin
Universite Paris Descartes, Paris, France
J Neurosci 29:4519-30. 2009b>Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA)...
- Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activityMagdalini A Papandreou
Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Greece
Behav Brain Res 198:352-8. 2009..PrB30) and 60 (PrB60) mg/kg body weight for 7 days, on cognitive performance, brain oxidative status and acetylcholinesterase activity in adult, male, 3-4-month-old Balb-c mice...
- Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic studyNicolaas I Bohnen
Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Neurol 60:1745-8. 2003..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
- Evidence for occurrence of an organophosphate-resistant type of acetylcholinesterase in strains of sea lice (Lepeophtheirus salmonis Krøyer)Anders Fallang
The Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
Pest Manag Sci 60:1163-70. 2004b>Acetylcholinesterase (AChE) is the target of a major pesticide family, the organophosphates, which were extensively used as control agents of sea lice on farmed salmonids in the early 1990s...
- Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.)Stefano Cassanelli
Department of Agricultural Science, University of Modena and Reggio Emilia, Reggio Emilia, Via JFK Kennedy 17 19, RE 42100, Italy
Insect Biochem Mol Biol 36:642-53. 2006..In the Raz strain, a target site resistance mechanism was suggested by the inhibition of acetylcholinesterase (AChE) activity...
- Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populationsHaoues Alout
Team Genomic of Adaptation, CNRS UMR 5554, Institut des Sciences de l Evolution, C C 065, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier, France
Insect Biochem Mol Biol 39:884-91. 2009Two amino acid substitutions in acetylcholinesterase 1 (AChE1), G119S and F290V, are responsible for resistance to organophosphate and carbamate insecticides in Culex pipiens mosquitoes...
- Termination and beyond: acetylcholinesterase as a modulator of synaptic transmissionGabriel Zimmerman
The Institute of Life Sciences and the Interdisciplinary Center for Neural Computation ICNC, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Cell Tissue Res 326:655-69. 2006..This unique termination mechanism makes acetylcholinesterase (AChE), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling...
- Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's diseaseLiat BenMoyal-Segal
The Life Sciences Institute, The Hebrew University of Jerusalem, Israel
FASEB J 19:452-4. 2005..Our findings suggest that inherited interactive weakness of AChE and PON1 expression increases the insecticide-induced occurrence of Parkinson's disease...
- Berberine: a potential multipotent natural product to combat Alzheimer's diseaseHong Fang Ji
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
Molecules 16:6732-40. 2011..In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and ..
- Integrated use of biomarkers (acetylcholinesterase and antioxidant enzymes activities) in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine areaM G Lionetto
Lab di Fisiologia Generale ed Ambientale, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita di Lecce, via prov le Lecce Monteroni, Italy
Mar Pollut Bull 46:324-30. 2003..The aim of the present work was the field application of the integrated use of acetylcholinesterase (AChE) and antioxidant enzymes (catalase--CAT, glutathione peroxidase--GSH-Px), for detecting the possible ..
- Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairmentsO Cohen
Department of Biological Chemistry, The Hebrew University of Jerusalem, 91905 Jerusalem, Israel
Mol Psychiatry 7:874-85. 2002..were explored in behaviorally impaired transgenic (Tg) FVB/N mice expressing synaptic human acetylcholinesterase (hAChE-S)...
- The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferationVarda R Deutsch
Department of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Exp Hematol 30:1153-61. 2002..b>Acetylcholinesterase (AChE) is expressed in mammalian neurons and hematopoietic cells...
- Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopeniaC Perry
Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Leukemia 21:1472-80. 2007Hematological changes induced by various stress stimuli are accompanied by replacement of the primary acetylcholinesterase (AChE) 3' splice variant acetylcholinesterase-S (AChE-S) with the myelopoietic acetylcholinesterase-R (AChE-R) ..
- Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathwayValentin A Pavlov
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
Brain Behav Immun 23:41-5. 2009..Here we report that brain acetylcholinesterase activity controls systemic and organ specific TNF production during endotoxemia...
- Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri LankaM Devika B Perera
Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
Malar J 7:168. 2008....
- Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonismMarco Giorgetti
Medivation, Inc, San Francisco, California 94105, USA
J Pharmacol Exp Ther 333:748-57. 2010..Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and the N-methyl-d-aspartate (NMDA) receptor, the low in vitro affinity for these targets suggests ..
- Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminataPradeep Kumar
Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India
Phytother Res 23:172-7. 2009..Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata...
- Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motilityI Mor
The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
J Cell Mol Med 12:479-95. 2008..A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues...
- Differential localization of acetylcholinesterase in neuronal and non-neuronal cellsMatthew D Thullbery
Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
J Cell Biochem 96:599-610. 2005b>Acetylcholinesterase (AChE) expression is regulated in cell types at the transcriptional and translational levels...
- Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesteraseDong Liang
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
J Biol Chem 284:5195-207. 2009The mammalian protein CutA was first discovered in a search for the membrane anchor of mammalian brain acetylcholinesterase (AChE). It was co-purified with AChE, but it is distinct from the real transmembrane anchor protein, PRiMA...
- ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activitiesD Grisaru
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
Mol Med 7:93-105. 2001..Here we report the involvement of the stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, and its 26 amino acid C-terminal domain (ARP) in hematopoietic stress responses...
- Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsHyun Ah Jung
Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
Biol Pharm Bull 32:1433-8. 2009..Coptidis Rhizoma were evaluated via beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) assays, along with peroxynitrite (ONOO(-)) scavenging and total ..
- High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural productsK Ingkaninan
Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
J Chromatogr A 872:61-73. 2000..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
- A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formationG V De Ferrari
Center for Cell Regulation and Pathology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, P. Catholic University of Chile and Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
Biochemistry 40:10447-57. 2001b>Acetylcholinesterase (AChE) has been found to be associated with the core of senile plaques...
- Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicityM F Frasco
IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
Biomarkers 10:360-75. 2005The enzymatic activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
- Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell linesMartina Zimmermann
Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Neurochem 90:1489-99. 2004b>Acetylcholinesterase inhibitors (AChEIs) are the only currently available drugs for treating Alzheimer's Disease (AD)...
- Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compoundsPelayo Camps
Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
J Med Chem 52:5365-79. 2009Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) ..
- Structural insights into substrate traffic and inhibition in acetylcholinesteraseJacques Philippe Colletier
Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale CEA CNRS UJF, Grenoble Cedex, France
EMBO J 25:2746-56. 2006b>Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine...
- Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesteraseK Tai
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
Biophys J 81:715-24. 2001A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with special attention paid to the fluctuation in the width of the gorge and opening events of the back door...
- Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosisR Deng
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Oncogene 25:7070-7. 2006It has been shown that acetylcholinesterase (AChE) expression was induced during apoptosis and the anti-sense oligonucleotides and siRNA of AChE may prevent apoptosis in various cell types...
- Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to organophosphorus insecticidesJu Chun Hsu
Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Council of Agriculture, 11 Kuang Ming Road, Wufeng 413, Taichung Hsien, Taiwan
Insect Biochem Mol Biol 36:396-402. 2006Mutations in the gene encoding the enzyme acetylcholinesterase (AChE) of the oriental fruit fly, Bactrocera dorsalis, associated with resistance to an organophosphorus insecticide have been characterized...
- Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behaviorKlara R Birikh
Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Israel
Proc Natl Acad Sci U S A 100:283-8. 2003..Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein ..
- Molecular and biochemical characterization of a sand fly population from Sri Lanka: evidence for insecticide resistance due to altered esterases and insensitive acetylcholinesteraseS N Surendran
Department of Zoology, University of Jaffna, Jaffna, Sri Lanka
Bull Entomol Res 95:371-80. 2005..Island collection was assayed for the activities of four enzyme systems involved in insecticide resistance (acetylcholinesterase, non-specific carboxylesterases, glutathione-S-transferases and cytochrome p450 monooxygenases), ..
- Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholineM M Mesulam
Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University, Chicago, IL 60611, USA
Neuroscience 110:627-39. 2002b>Acetylcholinesterase is one of the most prominent constituents of central cholinergic pathways...
- Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptorsAfrim H Bytyqi
Darmstadt University of Technology, Developmental Biology and Neurogenetics, D 64287 Darmstadt, Germany
Eur J Neurosci 20:2953-62. 2004..As an alternative, we show here for an acetylcholinesterase (AChE) knockout mouse that photoreceptor degeneration follows an impaired development of the inner retina...
- Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticidesYuan Ping Pang
Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 4:e4349. 2009..are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE)...
- Acetylcholinesterase in cell adhesion, neurite growth and network formationLaura E Paraoanu
Darmstadt University of Technology, Germany
FEBS J 275:618-24. 2008The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative ..
- Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathwaysR Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Neurology 65:1716-22. 2005..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo...
- N-acetylcholinesterase-induced apoptosis in Alzheimer's diseaseDebra Toiber
Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
PLoS ONE 3:e3108. 2008..Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.
- Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacologyIsrael Silman
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Curr Opin Pharmacol 5:293-302. 2005The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine...
- Mapping of brain acetylcholinesterase alterations in Lewy body disease by PETH Shimada
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
Neurology 73:273-8. 2009..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
- Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activityM H Oh
Department of Pharmacy, Pharmacognosy Research Laboratories, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 8WA, UK
Phytomedicine 11:544-8. 2004..calamus and E. koreanum. The possible bases for the reputation of these and the other herbs tested are discussed in the light of previous investigations into their chemistry and biological activity...
- Two different genes encoding acetylcholinesterase existing in cotton aphid (Aphis gossypii)Fei Li
College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, PR China
Genome 45:1134-41. 2002Two acetylcholinesterase (AChE) genes, Ace1 and Ace2, have been cloned from cotton aphid, Aphis gossypii Glover, using the rapid amplification of cDNA ends (RACE) technique...
- Acetylcholinesterase plays a pivotal role in apoptosome formationSang Eun Park
Department of Anatomy and Cell Biology BK21 program, Dong A University College of Medicine and Medical Science Research Center, Seo Gu, Busan, South Korea
Cancer Res 64:2652-5. 2004Although a recent study (Zhang et al. Cell Death Differ 2002; 9; 790-800) presented that acetylcholinesterase (AChE) might be an important common component in leading to various types of apoptosis, the molecular mechanism, by which AChE ..
- Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stabilityGerald B Downes
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Dev Biol 270:232-45. 2004The enzyme acetylcholinesterase (AChE) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine...
- The peripheral anionic site of acetylcholinesterase: structure, functions and potential role in rational drug designG Johnson
Department of Pediatric Surgery, University of Stellenbosch, Tygerberg, South Africa
Curr Pharm Des 12:217-25. 2006The peripheral anionic site of acetylcholinesterase lies at the entrance to the active site gorge...
- Calretinin immunohistochemistry versus acetylcholinesterase histochemistry in the evaluation of suction rectal biopsies for Hirschsprung DiseaseRaj P Kapur
Department of Laboratories, Chidren s Hospital and Regional Medical Center, Seattle, WA, USA
Pediatr Dev Pathol 12:6-15. 2009..b>Acetylcholinesterase histochemistry (AChE) facilitates diagnosis but is not universally employed, in part because it requires ..
- Molecular characterization of an acetylcholinesterase implicated in the regulation of glucose scavenging by the parasite SchistosomaAndrew K Jones
The School of Biology, University of Leeds, Leeds, West Yorkshire, UK, LS2 9JT
FASEB J 16:441-3. 2002b>Acetylcholinesterase (AChE) present on the surface of the trematode blood fluke Schistosoma has been implicated in the regulation of glucose scavenging from the host blood...
- Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in ratsVirginia C Moser
Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 114:113-23. 2010N-Methyl carbamate insecticides are reversible inhibitors of central and peripheral acetylcholinesterase (ChE). Despite their widespread use, there are few studies of neurotoxicity in young animals...
- RNAi of ace1 and ace2 in Blattella germanica reveals their differential contribution to acetylcholinesterase activity and sensitivity to insecticidesL Revuelta
Centro de Investigaciones Biologicas, CSIC, Departamento de Biología Medioambiental, Ramiro de Maeztu 9, 28006 Madrid, Spain
Insect Biochem Mol Biol 39:913-9. 2009Cyclorrhapha insect genomes contain a single acetylcholinesterase (AChE) gene while other insects contain at least two ace genes (ace1 and ace2)...
- Salivary acetylcholinesterase as a biomarker for organophosphate exposureVivian Ng
Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Occup Med (Lond) 59:120-2. 2009..Workers exposed to organophosphate (OP) pesticides are required to undergo periodic statutory medical surveillance in several countries...
- Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activityYong Kyung Lee
College of Pharmacy, Chungbuk National University, 12, Gaesin dong, Heungduk gu, Cheongju, Chungbuk, 361 763, Korea
J Nat Med 63:274-82. 2009..officinalis and 4-O-methylhonokiol also dose-dependently attenuated the scopolamine-induced increase of acetylcholinesterase (AChE) activity in the cortex and hippocampus of mice, and inhibited AChE activity in vitro with IC(50) (12 ..
- Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brainEthika Tyagi
Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, India
J Neuroimmunol 205:51-6. 2008..Proinflammatory cytokines (TNF-alpha and IL-1beta), acetylcholinesterase (AChE) activity, malondialdehyde (MDA) and reduced glutathione (GSH) were studied as markers for ..
- Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposureS K Richetti
Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
Neurotoxicology 32:116-22. 2011..the effects of the treatment with cadmium acetate, lead acetate, mercury chloride, and zinc chloride in acetylcholinesterase activity and gene expression pattern, as well as the effects of these treatments in antioxidant competence ..
- Accumulation of nodularin-like compounds from the cyanobacterium Nodularia spumigena and changes in acetylcholinesterase activity in the clam Macoma balthica during short-term laboratory exposureKari K Lehtonen
Finnish Institute of Marine Research, PO Box 33, FIN 00931 Helsinki, Finland
Aquat Toxicol 64:461-76. 2003..b>Acetylcholinesterase (AChE) activity was measured from the foot tissue samples taken at 0, 24 and 96 h...
- P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctionsEdmund K K Tung
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Rd, Hong Kong SAR, China
Mol Pharmacol 66:794-806. 2004..In differentiated myotubes, P2Y2 activation induced expression of acetylcholinesterase (AChE) protein (but not control alpha-tubulin)...
- Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regenerationKatarina Pegan
Laboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 187:96-100. 2010The best established role of acetylcholinesterase (EC 220.127.116.11, AChE) is termination of neurotransmission at cholinergic synapses...
- Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sitesG V De Ferrari
Department of Pharmacology and Program in Neurosciences, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
J Biol Chem 276:23282-7. 2001Three-dimensional structures of acetylcholinesterase (AChE) reveal a narrow and deep active site gorge with two sites of ligand binding, an acylation site at the base of the gorge, and a peripheral site near the gorge entrance...
- Acetylcholinesterase inhibition in the threeridge mussel (Amblema plicata) by chlorpyrifos: implications for biomonitoringW J Doran
River Studies Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin 54601, USA
Ecotoxicol Environ Saf 49:91-8. 2001..chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test...
- Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmissionEllen G Duysen
Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Toxicology 233:60-9. 2007Butyrylcholinesterase (EC 18.104.22.168 BChE) is present in all human and mouse tissues, and is more abundant than acetylcholinesterase (EC 22.214.171.124 AChE) in all tissues except brain...
- Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesteraseN Aurbek
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
Toxicology 224:91-9. 2006..OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with ..
- Layer-by-Layer self-assembled acetylcholinesterase/PAMAM-Au on CNTs modified electrode for sensing pesticidesYunhe Qu
Department of Chemistry, East China Normal University, Shanghai, PR China
Bioelectrochemistry 77:139-44. 2010In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples...
- Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesteraseW Xie
Eppley Institute, University of Nebraska Medical Center, Omaha 68198 6805, USA
J Pharmacol Exp Ther 293:896-902. 2000b>Acetylcholinesterase (AChE; EC 126.96.36.199) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development...
- Non-hydrolytic functions of acetylcholinesterase. The significance of C-terminal peptidesSusan A Greenfield
The Institute for the Future of the Mind, Oxford University, UK
FEBS J 275:604-11. 2008This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration...
- Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrineLygia Azevedo Marques
VU University Amsterdam, Faculty of Sciences, Section of Biomolecular Analysis, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
J Pharm Biomed Anal 53:609-16. 2010..for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE)...
- Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathwayNibaldo C Inestrosa
FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
Curr Alzheimer Res 2:301-6. 2005..The only treatment for AD has been the use of inhibitors of acetylcholinesterase (AChE) (E.C. 188.8.131.52), which is one of the several proteins associated with amyloid plaque deposits...
- Distribution of ace-1R and resistance to carbamates and organophosphates in Anopheles gambiae s.s. populations from Côte d'IvoireLudovic P Ahoua Alou
Institut Pierre Richet, BP 47 Abidjan, Cote d Ivoire
Malar J 9:167. 2010..It is, therefore, essential to investigate on the susceptibility of pyrethroid resistant populations of An. gambiae s.s. to these alternative products...
- Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous systemMarko Zivin
University of Ljubljana, School of Medicine, Institute of Pathophysiology, Brain Research Laboratory, 1000 Ljubljana, Slovenia
Psychiatr Danub 20:168-73. 2008b>Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles...
- beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studiesManuela Bartolini
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Biochem Pharmacol 65:407-16. 2003The aggregation of beta-amyloid (1-40) (Abeta) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by thioflavin T fluorescence spectroscopy...
- Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chainGlynis Johnson
Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
Biochem J 411:507-14. 2008Although the primary function of AChE (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth ..
- Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosaDae Keun Kim
College of Pharmacy, Woosuk University, Samrye 565 701, Korea
Arch Pharm Res 27:1127-31. 2004In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract ..
- Acetylcholine synthesis and possible functions during sea urchin developmentC Angelini
Department of Experimental, Environmental and Applied Biology, University of Genoa, Genoa, Italy
Eur J Histochem 48:235-43. 2004..b>Acetylcholinesterase (AChE, the lytic enzyme of acetylcholine) was also found in ovarian eggs, with a similar distribution; ..
- Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyriAbdelouahid Samadi
Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
Bioorg Med Chem 18:5861-72. 2010..The biological evaluation showed that some of these molecules were modest inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in the micromolar range...
- Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitorsLing Huang
The Industrial Institute of Fine Chemicals and Synthetic Drugs, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China
Bioorg Med Chem 18:1244-51. 2010By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Most of the derivatives inhibited AChE in the sub-micromolar range...
- X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangementH Dvir
Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Biochemistry 41:10810-8. 2002Kinetic and structural data are presented on the interaction with Torpedo californica acetylcholinesterase (TcAChE) of (+)-huperzine A, a synthetic enantiomer of the anti-Alzheimer drug, (-)-huperzine A, and of its natural homologue (-)-..
- Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocketA Ordentlich
Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
J Biol Chem 268:17083-95. 1993Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338...
- Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEsRichard Gordon; Fiscal Year: 2007..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy Lahiri; Fiscal Year: 2009..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
- Age and sex effects on nerve agent damage to the brain and antidotal therapiesEDSON ALBUQUERQUE; Fiscal Year: 2007..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
- ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNSJEEVENDRA MARTYN; Fiscal Year: 1993..messenger cyclic adenosine monophosphate (cAMP), prostaglandin E2 (PGE2) in muscle, and (3) depressed acetylcholinesterase enzyme activity with resultant decreased breakdown and increased levels of acetylcholine at the ..
- A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide NeurotoxicityYvonne Rosenberg; Fiscal Year: 2007..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2003..structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and terminal axon branching;..
- Use of an Organophosphorus (OP) Hydrolase for Acute OP PoisoningSteven Bird; Fiscal Year: 2007..The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
- Pope-Presynaptic modulation of anticholinesterase toxicityCarey N Pope; Fiscal Year: 2010Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2007..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPAUL CARLIER; Fiscal Year: 2009..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPaul R Carlier; Fiscal Year: 2010..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
- Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and NeuropathologyMARIA BRAGA; Fiscal Year: 2007..Nerve agents are organophosphates with high toxicity, whose primary action is the irreversible inhibition of acetylcholinesterase. Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy K Lahiri; Fiscal Year: 2010..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
- Aging and Sites of Action of Cognition-Enhancing DrugsDIANA WOODRUFF PAK; Fiscal Year: 2007..In addition to septohippocampal acetylcholine (ACh) routes of action, experiments will assess acetylcholinesterase inhibition (AChE-I) and nicotinic acetylcholine receptors (nAChRs) in cerebellum and cerebellar ..
- Organophosphorus Pesticide ToxicologyJOHN CASIDA; Fiscal Year: 2006..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
- Metabolism and Age-Related Organophosphate ToxicityJanice Chambers; Fiscal Year: 2005..of hepatic and blood detoxication mechanisms (the protective esterases: carboxylesterases, non-target acetylcholinesterase, butyrylcholinesterase, A-esterase) and target enzyme (brain and peripheral acetylcholinesterase) ..
- The neurogenic potential of cholinergic activation in AD.ELIZABETH ADAMS ECKMAN; Fiscal Year: 2010..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
- The neurogenic potential of cholinergic activation in AD.Elizabeth Eckman; Fiscal Year: 2009..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
- Organophosphate Action in the Central Nervous SystemNEIL MARC NATHANSON; Fiscal Year: 2010Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
- PRESYNAPTIC MODULATION OF ANTICHOLINESTERASE TOXICITYCarey Pope; Fiscal Year: 2000..from the Investigator's Abstract) Organophosphorus insecticides (OPs) exert toxicity through inhibition of acetylcholinesterase, allowing accumulation of acetylcholine and excessive stimulation of postsynaptic cholinergic receptors...