epoxide hydrolases

Summary

Summary: Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively. EC 3.3.2.3.

Top Publications

  1. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
  2. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
  3. pmc Epoxyeicosatrienoic acids and endothelium-dependent responses
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pflugers Arch 459:881-95. 2010
  4. pmc Soluble epoxide hydrolase is a therapeutic target for acute inflammation
    Kara R Schmelzer
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:9772-7. 2005
  5. pmc Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
    John D Imig
    Department of Pharmacology and Toxicology, Cardiovascular Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Drug Discov 8:794-805. 2009
  6. ncbi Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
  7. ncbi Manipulating the stereoselectivity of limonene epoxide hydrolase by directed evolution based on iterative saturation mutagenesis
    Huabao Zheng
    Max Planck Institut für Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mülheim an der Ruhr, Germany
    J Am Chem Soc 132:15744-51. 2010
  8. pmc Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
    Philippe de Medina
    Institut National de la Sante et de la Recherche Medicale, U563, Equipe Métabolisme, Oncogenése et Différenciation Cellulaire, 31052 Toulouse, France
    Proc Natl Acad Sci U S A 107:13520-5. 2010
  9. pmc Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis
    Guodong Zhang
    Department of Entomology, and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:6530-5. 2013
  10. ncbi 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase
    Caroline Morin
    Le Bilarium, Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 Canada
    Am J Respir Cell Mol Biol 43:564-75. 2010

Detail Information

Publications313 found, 100 shown here

  1. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
    ..Our results suggest conserved roles for balanced eicosanoid production in vertebrate resistance to mycobacterial infection...
  2. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..This data suggests that heterocyclic amines do not play an important role in the aetiology of colorectal cancer but that exposure to other carcinogens such as polycyclic aromatic hydrocarbons may be important determinants of cancer risk...
  3. pmc Epoxyeicosatrienoic acids and endothelium-dependent responses
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pflugers Arch 459:881-95. 2010
    ..Thus, the EETs are endothelium-derived hyperpolarizing factors mediating a portion of the relaxations to acetylcholine, bradykinin, shear stress, and cyclic stretch and regulate vascular tone in vitro and in vivo...
  4. pmc Soluble epoxide hydrolase is a therapeutic target for acute inflammation
    Kara R Schmelzer
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:9772-7. 2005
    ..These data suggest that sEH inhibitors have therapeutic efficacy in the treatment and management of acute inflammatory diseases...
  5. pmc Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
    John D Imig
    Department of Pharmacology and Toxicology, Cardiovascular Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Drug Discov 8:794-805. 2009
    ....
  6. ncbi Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  7. ncbi Manipulating the stereoselectivity of limonene epoxide hydrolase by directed evolution based on iterative saturation mutagenesis
    Huabao Zheng
    Max Planck Institut für Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mülheim an der Ruhr, Germany
    J Am Chem Soc 132:15744-51. 2010
    ..In order to explain some of the stereoselective consequences of the observed mutations, a simple model based on molecular dynamics simulations has been proposed...
  8. pmc Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
    Philippe de Medina
    Institut National de la Sante et de la Recherche Medicale, U563, Equipe Métabolisme, Oncogenése et Différenciation Cellulaire, 31052 Toulouse, France
    Proc Natl Acad Sci U S A 107:13520-5. 2010
    ..Taken together, our findings strongly suggest that the AEBS carries out ChEH activity and establish that ChEH is a new target for drugs of clinical interest, polyunsaturated fatty acids and ring B oxysterols...
  9. pmc Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis
    Guodong Zhang
    Department of Entomology, and Comprehensive Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:6530-5. 2013
    ..These results designate epoxyeicosatrienoic acids and EDPs as unique endogenous mediators of an angiogenic switch to regulate tumorigenesis and implicate a unique mechanistic linkage between omega-3 and omega-6 fatty acids and cancers...
  10. ncbi 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase
    Caroline Morin
    Le Bilarium, Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 Canada
    Am J Respir Cell Mol Biol 43:564-75. 2010
    ..These results demonstrate that 17,18-EpETE is a potent regulator of human lung inflammation and concomitant hyperresponsiveness, and may represent a valuable asset against critical inflammatory bronchial disorder...
  11. pmc Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Carcinog 50:397-402. 2011
    ..11, 95% CI: 1.00-1.23, P = 0.04). These findings are consistent with prior studies implicating these genes in carcinogenesis and suggest that this collection of variants is worthy of follow-up in additional studies...
  12. pmc Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
    Matthew L Edin
    Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 25:3436-47. 2011
    ..These data demonstrate that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R...
  13. pmc Determinants of reactivity and selectivity in soluble epoxide hydrolase from quantum mechanics/molecular mechanics modeling
    Richard Lonsdale
    Centre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock s Close, Bristol BS8 1TS, UK
    Biochemistry 51:1774-86. 2012
    ..b>Epoxide hydrolases therefore have potential synthetic applications...
  14. ncbi Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
    Le Ning Zhang
    Arete Therapeutics Inc, South San Francisco, CA 94080, USA
    Eur J Pharmacol 654:68-74. 2011
    ..Thus, preserving vasodilator EETs by inhibition of s-EH may be of therapeutic benefit by improving endothelial function in cardiometabolic diseases...
  15. pmc Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
    Douglas R Davies
    deCODE BioStructures, Inc, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA
    J Med Chem 52:4694-715. 2009
    ..Analysis of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chemical features and binding modes of several reported LTA4H inhibitors...
  16. ncbi Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase
    Sundarapandian Thangapandian
    Division of Applied Life Science, BK21 Program, Environmental Biotechnology National Core Research Center, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, 900 Gazwa dong, Jinju 660 701, Republic of Korea
    J Chem Inf Model 51:33-44. 2011
    ..Reverse validation was performed to ensure the results of the study...
  17. ncbi Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population
    Ivona Hlavata
    Toxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic
    Oncol Rep 24:1347-53. 2010
    ..These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis...
  18. ncbi Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia
    Le Ning Zhang
    Arete Therapeutics Inc, 3912 Trust Way, Hayward, CA 94545, USA
    Arterioscler Thromb Vasc Biol 29:1265-70. 2009
    ..Thus, inhibition of s-EH can prevent degradation of EETs and prolong their effects. The present study aimed to test the hypothesis that inhibition of s-EH has vascular protective effects...
  19. ncbi SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan
    Ling I Hsu
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Toxicol Appl Pharmacol 228:144-55. 2008
    ..These observations implied that impaired metabolism of carcinogenic exposure as well as impaired DNA repair function play an important role in arsenic-related urinary transitional cell carcinogenesis...
  20. pmc A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
    ..These studies imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated levels of PGP...
  21. ncbi Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk
    Jordi To-Figueras
    Toxicology Unit, ORL Unit, Hospital Clinic, IDIBAPS, Ciutat Sanitaria de Bellvitge, Departament de Salut Publica, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cancer Lett 187:95-101. 2002
    ..173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers...
  22. ncbi Epoxide hydrolases: their roles and interactions with lipid metabolism
    John W Newman
    Department of Entomology, UCDavis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Prog Lipid Res 44:1-51. 2005
    The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform epoxide containing lipids by the addition of water...
  23. ncbi Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
    C J Sinal
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:40504-10. 2000
    ..These data provide the first direct evidence for a role for soluble epoxide hydrolase in blood pressure regulation and identify this enzyme as a novel and attractive target for therapeutic intervention in hypertension...
  24. ncbi Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1
    J Brøgger
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Helse Bergen HF, Jonas Liesv 65, Bergen N 5021, Norway
    Eur Respir J 27:682-8. 2006
    ..In conclusion, the present data and meta-analysis support a role for microsomal epoxide hydroxylase in the aetiology of chronic obstructive pulmonary disease...
  25. ncbi Epoxide hydrolases: biochemistry and molecular biology
    A J Fretland
    Department of Environmental Health, of Washington, 4225 Roosevelt Way NE, 100 Seattle, WA 98105 6099, USA
    Chem Biol Interact 129:41-59. 2000
    ..The epoxide hydrolases (E.C. 3.3.2...
  26. pmc The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
    John W Newman
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 100:1558-63. 2003
    ..35 +/- 0.01 s(-1). Therefore dihydroxy lipid phosphates are possible candidates for the endogenous substrates of the sEH N-terminal domain, which would represent a novel branch of fatty acid metabolism with potential signaling functions...
  27. ncbi Microbial epoxide hydrolases for preparative biotransformations
    A Steinreiber
    Department of Chemistry, Organic and Bio-Organic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
    Curr Opin Biotechnol 12:552-8. 2001
    b>Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale...
  28. pmc Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1475-81. 2009
    ..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...
  29. pmc Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1
    K A McGlynn
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 92:2384-7. 1995
    ....
  30. pmc Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels
    Jeffrey J Iliff
    Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Am J Physiol Heart Circ Physiol 296:H1352-63. 2009
    ..The findings have important implications to such clinical conditions as migraine, vasospasm after subarachnoid hemorrhage, and stroke...
  31. ncbi Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching
    Dengguo Wei
    Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Med Chem 51:7882-8. 2008
    ..3 microM, respectively. The common pharmacophore model can also be used to search small molecule databases or collections of existing inhibitors, as well as to guide combinatorial library design to search for ideal multitarget inhibitors...
  32. pmc Distribution and expression of soluble epoxide hydrolase in human brain
    Priyanka Sura
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
    J Histochem Cytochem 56:551-9. 2008
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  33. ncbi Susceptibility genes for rapid decline of lung function in the lung health study
    A J Sandford
    The University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 163:469-73. 2001
    ..9, p = 0.04). The alpha1-antitrypsin S and 3' polymorphisms, vitamin D-binding protein isoforms, and tumor necrosis factor (TNF-alpha G-308A and TNF-beta A252G) polymorphisms were not associated with rate of decline of lung function...
  34. ncbi Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase
    M Shou
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 35:15807-13. 1996
    ..Our results provide a clear understanding of how these enzymes catalyze overall stereoselective metabolism at the K-region of the PAHs...
  35. pmc 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain
    Tristan E Rose
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616, USA
    J Med Chem 53:7067-75. 2010
    ..This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model...
  36. ncbi The cytochrome P450 pathway in angiogenesis and endothelial cell biology
    Ingrid Fleming
    Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cancer Metastasis Rev 30:541-55. 2011
    ..This review summarizes current knowledge on the aspects of the cytochrome P450/soluble epoxide hydrolase pathway related to vascular homeostasis and cancer...
  37. pmc Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
    Pengcheng Luo
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 334:430-8. 2010
    ..These results show not only that sEH KO and its inhibition prevent hyperglycemia in diabetes, but also that sEH KO enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes...
  38. ncbi Cholesterol epoxide hydrolase and cancer
    Sandrine Silvente-Poirot
    Cancer Research Center of Toulouse, UMR 1037 INSERM University Toulouse III, Institut Claudius Regaud, Toulouse, France
    Curr Opin Pharmacol 12:696-703. 2012
    ....
  39. pmc Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis
    Xiang Li
    Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Sino France Joint Center for Drug Research and Screening, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 6:e14749. 2011
    ..Two functional polymorphisms in the EPHX1 gene, Tyr113His and His139Arg can alter the enzyme activity, suggesting their possible association with carcinogenesis risk, particularly of some tobacco-related cancers...
  40. pmc Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols
    Timo Frömel
    Institute for Vascular Signalling, Goethe University, Frankfurt am Main D 60596, Germany
    Proc Natl Acad Sci U S A 109:9995-10000. 2012
    ..Thus, sEH activity is required for optimal progenitor cell proliferation, whereas long-term sEH inhibition is detrimental to progenitor cell proliferation, mobilization, and vascular repair...
  41. pmc Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 21:615-23. 2011
    ..To explore associations with prostate cancer and farming, it is important to investigate the relationship between pesticide use and single nucleotide polymorphisms (SNPs) in xenobiotic metabolic enzyme (XME) genes...
  42. ncbi Structure-function relationships of epoxide hydrolases and their potential use in biocatalysis
    Mikael Widersten
    Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE 751 23 Uppsala, Sweden
    Biochim Biophys Acta 1800:316-26. 2010
    Chiral epoxides and diols are important synthons for manufacturing fine chemicals and pharmaceuticals. The epoxide hydrolases (EC 3.3.2.-) catalyze the hydrolytic ring opening of epoxides producing the corresponding vicinal diol...
  43. ncbi Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors
    Philippe de Medina
    Institut National de la Santé et de la Recherche Médicale U 563, Toulouse, France
    Mol Pharmacol 78:827-36. 2010
    ..We further established that these effects correlated well with the control of growth and invasiveness of tumor cells. Our data shed light on the molecular mechanism underlying the anticancer and chemopreventive effects of auraptene...
  44. pmc Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP
    Bora Inceoglu
    Department of Entomology and University of California Davis Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:5093-7. 2011
    ..The cross-talk between the two major pathways-one mediated by cAMP and the other by EFAs-paves the way to new approaches to understand and control pain...
  45. pmc The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
    Annette Cronin
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:1552-7. 2003
    ..Thus, we propose this domain participates instead in the regulation of the physiological functions associated with sEH...
  46. ncbi A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  47. ncbi EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians
    Polat Dura
    Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands
    Oncol Rep 27:1710-6. 2012
    ..In conclusion, the polymorphisms in exon 3 and exon 4 of the EPHX1 gene do not seem to be modifiers of esophageal squamous cell carcinoma or esophageal adenocarcinoma risk in Dutch Caucasians...
  48. pmc Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase
    Sung Hee Hwang
    Department of Entomology, University of California, Davis, California 95616 8584, United States
    J Med Chem 54:3037-50. 2011
    ..Thus, these novel dual inhibitors exhibited enhanced in vivo antiallodynic activity in a nociceptive behavioral assay...
  49. ncbi Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma
    Armando G Amador
    Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis 46202 5186, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:440-5. 2002
    ..The objective was to determine the prevalence of the polymorphisms of the microsomal epoxide hydrolase (Ephx1), glutathione S-transferase mu1 (GSTM ), theta1 (GSTT1), and pi1 (GSTP1) genes in patients with oropharyngeal carcinoma...
  50. ncbi The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
    J W Holloway
    Divisios of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Allergy 63:1046-53. 2008
    ..Single nucleotide polymorphism (SNPs) and haplotypes spanning the LTA4H and ALOX5AP genes have been associated with LTB(4) production and myocardial infarction (MI)...
  51. ncbi Reaction mechanism of soluble epoxide hydrolase: insights from molecular dynamics simulations
    Birgit Schiøtt
    Department of Chemistry, Aarhus University, 8000 Aarhus, Denmark
    J Am Chem Soc 124:14558-70. 2002
    ..This overall anti-correlated collective domain motion is, perhaps, involved in the conversion of E.NAC to E.TS...
  52. ncbi Insights into the reaction mechanism of soluble epoxide hydrolase from theoretical active site mutants
    Kathrin H Hopmann
    Department of Theoretical Chemistry, School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    J Phys Chem B 110:21299-310. 2006
    ..calculations of active site mutants are used to gain insights into the reaction mechanism of the soluble epoxide hydrolases (sEHs)...
  53. pmc Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
    Abishek Iyer
    School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia
    Exp Diabetes Res 2012:758614. 2012
    ..The present study describes the pharmacological responses to this selective sEH inhibitor in rats with the signs of diet-induced metabolic syndrome...
  54. ncbi Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    Vincent Sandanayaka
    Medicinal Chemistry, deCODE Chemistry, Inc, 2501 Davey Road, Woodridge, Illinois 60517, USA
    J Med Chem 53:573-85. 2010
    ..This is the first example of a gene-to-clinic paradigm enabled by a fragment-based drug discovery effort...
  55. ncbi The telltale structures of epoxide hydrolases
    Michael Arand
    Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany
    Drug Metab Rev 35:365-83. 2003
    Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds...
  56. ncbi Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study
    Panagiota N Mitrou
    Dunn Human Nutrition Unit, MRC Wellcome Trust Building, Hills Road, Cambridge CB2 2XY, UK
    Carcinogenesis 28:875-82. 2007
    ..Alcohol increases risk of colorectal adenoma in carriers of the high-activity genotype possibly through enhanced activation of alcohol-related procarcinogens...
  57. ncbi Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases
    John D Imig
    Vascular Biology Ctr, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Renal Physiol 289:F496-503. 2005
    ..Thus the renal and cardiovascular protective actions of increasing epoxygenase levels could be translated to therapies for preventing end-organ damage...
  58. ncbi Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer
    Meenu Jain
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India
    Toxicol Appl Pharmacol 230:247-51. 2008
    ..However, His139Arg genotype of exon 4, exhibited low risk for ESCC as well as its clinical characteristics...
  59. pmc Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance
    Ayala Luria
    Department of Entomology, Division of Nephrology, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:9038-43. 2011
    ..These observations were supported by pharmacological inhibition of sEH. These data suggest that an increase in EETs due to sEH-gene knockout leads to an increase in the size of islets and improved insulin signaling and sensitivity...
  60. pmc Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways
    Bora Inceoglu
    Department of Entomology and UC Davis Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:18901-6. 2008
    ..Redirecting the flow of pronociceptive intracellular cAMP toward up-regulation of StARD1 mRNA by concomitantly elevating EETs is a novel path to accomplish pain relief in both inflammatory and neuropathic pain states...
  61. pmc Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
    Marlina Manhiani
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 297:F740-8. 2009
    ..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension...
  62. ncbi [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
    Chul Ho Jeong
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:5584-91. 2009
    ..Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer...
  63. pmc Development of a high-throughput screen for soluble epoxide hydrolase inhibition
    Nicola M Wolf
    Department of Plant Sciences, Center of Life Sciences Weihenstephan, Technische Universitat Munchen, 85350 Freising, Germany
    Anal Biochem 355:71-80. 2006
    ..7 proved the system's robustness and potential for HTS. The developed assay system will be a valuable tool to discover new structures for the therapeutic inhibition of sEH to treat various cardiovascular diseases...
  64. ncbi Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China
    L Yin
    School of Public Health, Southeast University, Nanjing, PR China
    Lung Cancer 33:133-41. 2001
    ..71-18.68). The association was also found with squamous cell carcinoma (OR, 3.23; 95% CI, 1.00-10.38). Our results suggest that HYL1*2 polymorphism might be a risk factor for smoking-associated lung cancer in China...
  65. ncbi The role of epoxide hydrolase Y113H gene variant in pancreatic diseases
    Johann Ockenga
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Germany
    Pancreas 38:e97-e101. 2009
    ..We studied the role of the EPHX1 c.337T>C (p.Y113H) variant, whichleads to altered enzyme activity, in pancreatic diseases...
  66. ncbi Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India
    Rakhshan Ihsan
    Institute of Pathology, New Delhi, India
    J Gastroenterol Hepatol 25:1456-62. 2010
    ....
  67. ncbi Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia
    Carlos H Sierra-Torres
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
    Environ Mol Mutagen 41:69-76. 2003
    ..Further studies using larger populations will be needed to confirm our observations and to validate data for disease prevention...
  68. ncbi Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD
    S L Cheng
    Dept of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    Eur Respir J 23:818-24. 2004
    ..In addition, the homozygous variant of microsomal epoxide hydrolase exon 3 and the glutathione S-transferase M1-null genotype are independent risk factors for developing severe chronic obstructive pulmonary disease...
  69. ncbi Structures and mechanisms of enzymes in the leukotriene cascade
    Agnes Rinaldo-Matthis
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochimie 92:676-81. 2010
    ..This chapter reviews the biochemistry, catalytic, and structural properties of the enzymes in the leukotriene cascade...
  70. ncbi Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk
    Emma L Northwood
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital
    Pharmacogenet Genomics 20:315-26. 2010
    ....
  71. ncbi Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation
    M M Thunnissen
    Department of Biochemistry, University of Stockholm, Arrhenius Laboratories A4, S 106 91 Stockholm, Sweden
    Nat Struct Biol 8:131-5. 2001
    ....
  72. ncbi Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India
    DNA Cell Biol 28:573-7. 2009
    ..Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28). mEPHX haplotypes shared a positive association with HCC risk in India...
  73. pmc Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Prostaglandins Other Lipid Mediat 82:50-9. 2007
    ..A better understanding of these relationships will facilitate identification of novel targets for the prevention and/or treatment of ischemic heart disease, a major worldwide public health problem...
  74. pmc Soluble epoxide hydrolase: a novel therapeutic target in stroke
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:1931-40. 2007
    ..The findings suggest that sEH inhibition is protective against ischemic injury by non-vascular mechanisms, and that sEH may serve as a therapeutic target in stroke...
  75. pmc Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma
    Achraf Khedhaier
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Tunisia
    BMC Cancer 8:109. 2008
    ..This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients...
  76. ncbi Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition
    X Fang
    Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:14867-74. 2001
    ..The modulation of EET metabolism by DCU provides novel insight into the mechanisms by which pharmacological or molecular inhibition of sEH effectively treats hypertension...
  77. ncbi Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design
    Fredrik Tholander
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institute, Stockholm, Sweden
    Chem Biol 15:920-9. 2008
    ..Our data provide detailed insights to the active site chemistry of M1 aminopeptidases and will aid in the development of novel enzyme inhibitors...
  78. pmc Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia
    Wenri Zhang
    Oregon Health and Science University, Department of Anesthesiology and Peri Operative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Stroke 39:2073-8. 2008
    ..We tested the hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow...
  79. ncbi Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
    Elise M J van der Logt
    Department of Gastroenterology, University Medical Centre, St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mutat Res 593:39-49. 2006
    ..In conclusion, these data suggest that the presence of variant NQO1 genotypes, with expected reduced enzyme activities might enhance susceptibility to CRC...
  80. pmc Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Circ Res 99:442-50. 2006
    ..Together, these data suggest that targeted disruption of sEH increases the availability of cardioprotective EETs that work by activating PI3K signaling pathways and K+ channels...
  81. pmc Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
    Danyan Xu
    Division of Cardiovascular Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:18733-8. 2006
    ..We conclude that the use of sEHIs to increase the level of the endogenous lipid epoxides such as EETs may represent a viable and completely unexplored avenue to reduce cardiac hypertrophy by blocking NF-kappaB activation...
  82. ncbi Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
    John D Imig
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 39:690-4. 2002
    ..Moreover, sEH plays a role in the regulation of blood pressure, and inhibition of sEH during Ang II hypertension is antihypertensive...
  83. ncbi CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer
    Stefania Boccia
    Genetic Epidemiology and Molecular Biology Unit, Institute of Hygiene, Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
    J Cancer Res Clin Oncol 134:93-100. 2008
    ..As risk-modifiers of alcohol and tobacco effects, metabolic genes polymorphisms were investigated as susceptibility candidates for squamous cell carcinoma of the head and neck (SCCHN)...
  84. pmc Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk
    Sean P Cleary
    Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 172:1000-14. 2010
    ..03) status. These findings support the hypothesis that prolonged cigarette smoking is associated with increased risk of colorectal cancer and that this risk may be modified by variation in carcinogen metabolism genes...
  85. pmc Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
    Jun Yan Liu
    Department of Entomology and UCD Cancer Research Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Pharmacol 156:284-96. 2009
    ..Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI...
  86. pmc Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    Hong Qiu
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8161-6. 2006
    ..The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis...
  87. ncbi Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
    Martina Decker
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurer Str 190, 8057 Zurich, Switzerland
    Arch Toxicol 83:297-318. 2009
    b>Epoxide hydrolases catalyse the hydrolysis of electrophilic--and therefore potentially genotoxic--epoxides to the corresponding less reactive vicinal diols, which explains the classification of epoxide hydrolases as typical detoxifying ..
  88. ncbi Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
    Peter C Rudberg
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 279:27376-82. 2004
    ..In conclusion, Arg(563) and Lys(565) possess distinct roles as carboxylate recognition sites for two chemically different substrates, each of which is turned over in separate enzymatic reactions catalyzed by LTA(4) hydrolase...
  89. ncbi Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett Street, Melbourne, Victoria, 8006, Australia
    Cancer Lett 177:75-81. 2002
    ..Furthermore previous disease association studies of exon 3 alleles which utilized the PCR-RFLP assay may be compromised by the existence of a codon 119 G>A polymorphism which may be common in Caucasian populations...
  90. pmc Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Epidemiol 173:404-13. 2011
    ..77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings...
  91. ncbi Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary
    Istvan Kiss
    Department of Preventive Medicine, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 27:2931-7. 2007
    ....
  92. ncbi Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    DNA Cell Biol 27:687-94. 2008
    ..GST and mEPHX variants share a positive association with viral-related HCC risk in Indian population, although a larger sample size is still required to confirm the results...
  93. ncbi Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
    Xueying Zhao
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
    J Am Soc Nephrol 15:1244-53. 2004
    ..These data demonstrate that SEH inhibition has antihypertensive and renal vascular protective effects in angiotensin hypertension and suggests that SEH inhibitors may be a useful therapeutic intervention for cardiovascular diseases...
  94. ncbi Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors
    Sundarapandian Thangapandian
    Division of Applied Life Science BK21 program, Environmental Biotechnology National Core Research Center EB NCRC, Gyeongsang National University GNU, 900 Gazwa dong, Jinju 660 701, Republic of Korea
    Eur J Med Chem 46:1593-603. 2011
    ..Molecular docking study was employed to identify the compounds that bind the active site with high affinity. Developed Bayesian model suggested molecular features favoring and not favoring the inhibition of hLTA4H...
  95. pmc Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids
    Christophe Morisseau
    Department of Entomology and Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    J Lipid Res 51:3481-90. 2010
    ..Consequently, the DHA and eicosapentaenoic acid epoxides may be responsible for some of the beneficial effects associated with dietary n-3 fatty acid intake...
  96. ncbi Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India
    Daya Shankar Srivastava
    Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India
    Arch Toxicol 82:633-9. 2008
    ..No associations were observed with stage or grade of bladder tumor with these genotypes. In conclusion, our study demonstrated that exon 3 His genotype of the mEH are more prone to the risk of sporadic bladder cancer in North India...
  97. pmc Expression and regulation of soluble epoxide hydrolase in adipose tissue
    Bart M De Taeye
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:489-98. 2010
    ....
  98. pmc Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation
    Benjamin B Davis
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:2222-7. 2002
    ..Metabolism of these compounds by epoxide hydrolases results in the formation of compounds that affect the vasculature in a pleiotropic manner...
  99. ncbi EPHX1 gene polymorphisms and individual susceptibility to lung cancer
    Anu Voho
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Cancer Lett 237:102-8. 2006
    ..Neither was any difference seen in the prevalence of the EPHX1 Tyr113His genotypes or interpreted EPHX1 phenotypes in the different age groups...
  100. ncbi Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase
    T Shimada
    Osaka Prefectural Institute of Public Health, 3 69 Nakamichi 1 chome, Higashinari ku, Osaka 537, Japan
    Chem Res Toxicol 12:623-9. 1999
    ....
  101. pmc Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain
    Bora Inceoglu
    Department of Entomology, University of California Davis Cancer Center, One Shields Avenue, Davis, CA 95616, United States
    Life Sci 79:2311-9. 2006
    Soluble epoxide hydrolases catalyze the hydrolysis of epoxides in acyclic systems. In man this enzyme is the product of a single copy gene (EPXH-2) present on chromosome 8...

Research Grants62

  1. Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Mary Jackson; Fiscal Year: 2012
    ..The genome of M. tb potentially encodes seven proteins related to epoxide hydrolases, some of which appear to be involved in the introduction of functional groups in mycolic acids and to be ..
  2. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce D Hammock; Fiscal Year: 2013
    ..A set of under-studied metabolic enzymes include the epoxide hydrolases in the ?/?-hydrolase fold family. These enzymes degrade epoxides by adding water...
  3. Interindividual Variability in Human Microsomal Epoxide Hydrolase
    Curtis J Omiecinski; Fiscal Year: 2012
    ..This research program will characterize the critical features that account for these differences and investigate their roles as risk modifiers of human diseases. ..
  4. Identification of novel therapeutic approaches for TETS and OP intoxication
    Michael A Rogawski; Fiscal Year: 2011
    ..this research project is to test the hypothesis that AMPA receptor antagonists and/or inhibitors of soluble epoxide hydrolases will significantly improve outcome following exposure to acutely toxic levels of TETS and parathion by ..
  5. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ....
  6. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2007
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  7. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2004
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  8. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  9. HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
    Jonathan Ward; Fiscal Year: 2005
    ..how genetic variation in mEH influences human sensitivity to the genotoxic effects of BD, and better understand the role of variants in biotransformation genes in modifying human susceptibility to toxic chemicals ..
  10. PROSTATIC GLUTATHIONE S-EPOXIDE TRANSFERASES
    CARL SCHAFFNER; Fiscal Year: 1991
    ..5.1.18) and epoxide hydrolases (EC 3.3.2.3) as isoenzymes will be examined in detail...
  11. Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase
    DANIEL S LEVY; Fiscal Year: 2010
    ..abstract_text> ..
  12. EPOXIDE HYDROLASE STUDIES AND PHENYTOIN INDUCED CLEFTING
    James Hartsfield; Fiscal Year: 2000
    ..This may led to the consideration of alternative maternal anticonvulsant therapeutics. ..
  13. XENOBIOTIC-METABOLIZING ENZYMES IN HUMAN LUNG
    Thomas Guenthner; Fiscal Year: 1990
    ..g. cytochrome P-450 isozymes or structurally unrelated epoxide hydrolases), and to variants of a single specific enzyme form (microsomal epoxide hydrolase)...
  14. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..The ultimate goal of this study is to determine whether or not these biomarkers can be useful as markers for risk assessment in humans exposed to PAHs at low ambient levels in future large scale epidemiological studies. ..
  15. MULTIPLICITY OF HUMAN XENOBIOTIC-METABOLIZING ENZYMES
    Thomas Guenthner; Fiscal Year: 1991
    ..g. cytochrome P-450 isozymes or structurally unrelated epoxide hydrolases), and to variants of a single specific enzyme form (microsomal epoxide hydrolase)...
  16. MEMBRANE BOUND DETOXICATION ENZYMES
    Richard Armstrong; Fiscal Year: 2000
    ....
  17. MOLECULAR TOXICOLOGY OF EPOXIDE HYDROLASE
    CURTIS OMIECINSKI; Fiscal Year: 2002
    ....
  18. Gene-Environment Interactions in RA Autoimmunity and Disease Severity
    Ted Mikuls; Fiscal Year: 2009
    ..We anticipate that the results of this study will be extended to other RA populations. ..
  19. LINOLEIC ACID DIOLS--A NEW CLASS OF CYTOTOXIC COMPOUNDS
    David Grant; Fiscal Year: 2000
    ..This work will provide a basis for developing specific inhibitors of epoxide hydrolases in order to prevent the formation of these compounds during acute inflammation in humans.
  20. Cyanohydrin based fluorescent substrates of sEH (RMI)
    Christophe Morisseau; Fiscal Year: 2004
    ..This will be done by screening the combinatorial libraries from the "NIH Roadmap", libraries contracted from commercial vendors, and more defined libraries generated in house. ..
  21. Elucidation of epoxide hydrolase polymorphisms
    Jong Park; Fiscal Year: 2002
    ....
  22. Epigenetic Markers for Lung Cancer Detection
    Jong Park; Fiscal Year: 2006
    ..The proposed study will generate data that will be the groundwork for larger studies to validate the use of the identified methylation sites to develop markers for early lung cancer diagnosis. ..
  23. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will test the hypothesis that endogenous LO metabolites are important regulators of vascular tone and blood pressure in mice. ..
  24. Biochemical and Metabolic Properties of 10-HETE
    ARTHUR SPECTOR; Fiscal Year: 2006
    ..The ultimate goal of this project is to provide the additional mechanistic insight necessary to develop new therapeutic approaches to overcome the pathological actions of 20-HETE. ..
  25. Novel epoxide hydrolase inhibitor for stroke prevention
    JOHN IMIG; Fiscal Year: 2005
    ..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
  26. Regulation of Nuclear Import/Export of 5-Lipoxygenase
    Thomas Brock; Fiscal Year: 2006
    ..This foundation can then be used to elucidate the ways these factors can change and give rise to the disease states that arise from abnormal 5-LO localization and LT synthesis. ..
  27. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  28. LC-MS/MS for Biomedical Research
    William Campbell; Fiscal Year: 2004
    ..About 75-80% of instrument time will be available to these participants and the remaining time will be available to other investigators at the College. ..
  29. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  30. Nitric Oxide Regulation of Adrenal Steroidogenesis
    William Campbell; Fiscal Year: 2004
    ..4) We will determine the role of endothelial NO in regulating steroidogenesis and adrenal blood flow in the in situ perfused adrenal gland and in vivo in anesthetized rats. ..
  31. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  32. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  33. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  34. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
    ....
  35. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
    ..They will also advance tailoring of chemoprevention in a way that maximizes benefit and minimizes toxicity. ..
  36. CARDIOTONIC STEROIDS FROM THE ADRENAL GLAND
    Peter Doris; Fiscal Year: 2002
    ..abstract_text> ..
  37. BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBES
    James F Rusling; Fiscal Year: 2010
    ..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
  38. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..
  39. Roles of CYP1 & 19 in Fundulus Steroids & PAH Metabolism
    Kristine Willett; Fiscal Year: 2009
    ..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
  40. Prostaglandin Synthesis and Action in the Primate Corpus Luteum
    Jon D Hennebold; Fiscal Year: 2010
    ..Such an understanding of PG involvement in the regulation of luteal structure-function may aid in our undestanding of infertility or other disorders associated with luteal dysfunction. ..
  41. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  42. Warfarin Pharmacogenetics in Pediatric Patients
    RONALD N contact HINES; Fiscal Year: 2010
    ..The IWPC clearly stated that additional research was needed with respect to the development of a similar algorithm for children and young adults. The proposed research will fill this important knowledge gap. ..
  43. MECHANISMS OF TOXICITY GORDON CONFERENCE
    RONALD HINES; Fiscal Year: 2002
    ..There also is substantial involvement of new personnel as Chairs and co-Chairs. Thus, the Mechanism of Toxicity GRC is poised to continue its growth as the single leading small conference on Molecular Toxicology. ..
  44. Exercise effects on oxidative damage among women
    Cornelia Ulrich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. RA Comorbidity Bone Health in Men and African Americans
    Ted Mikuls; Fiscal Year: 2008
    ..Mikuls' continued development as an independent clinical investigator. ..
  46. FUNCTIONAL GENOMICS OF ARTERIAL THROMBOSIS
    Myriam Fornage; Fiscal Year: 2004
    ..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..
  47. Equipment Support for USD Laboratory Animal Services
    Douglas Martin; Fiscal Year: 2005
    ..The long-term goal is to achieve AAALAC accreditation. It is expected that AAALAC review for accreditation will be requested within 18 months of completion and occupancy of the new LAS. ..
  48. Implications of Genomics Research on Racial Definition
    Seymour Garte; Fiscal Year: 2003
    ..A new paradigm of gene-specific variation will be developed for a biomedically useful method of division of the human population into groups based on criteria different from current definitions of race. ..
  49. CYP2J2 Derived Eicosanoids and Endothelial Function
    Craig Lee; Fiscal Year: 2005
    ..abstract_text> ..
  50. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  51. NQ01, Oxidative Stress and Proteasomal Inhibition
    David Ross; Fiscal Year: 2006
    ..The ability of mutant NQO1 *2 protein to generate oxygen radicals becomes particularly important under conditions where the UPS is inhibited and the protein accumulates. ..
  52. Disruption of Glutathione S-Transferase M1 in Mice
    MARGIE CLAPPER; Fiscal Year: 2006
    ..abstract_text> ..
  53. NQO1 in Protection Against Benzene Toxicicity
    David Ross; Fiscal Year: 2007
    ..abstract_text> ..
  54. HMGB1/2 and Cellular Response to Fraudulent Nucleosides
    Evgeny Krynetskiy; Fiscal Year: 2007
    ..abstract_text> ..
  55. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..
  56. Epoxide Hydrolases: Discovery and Synthetic Applications
    Lishan Zhao; Fiscal Year: 2003
    ..b>Epoxide hydrolases, which catalyze the hydrolysis of racemic epoxides to generate both the corresponding diols and the un-..
  57. Lovelace Respiratory Symposium 2003
    Rogene Henderson; Fiscal Year: 2003
    ..Future topics will be developed with the same sensitivity to meeting the information needs of our audience. Continuing medical education credits are available through the University of New Mexico School of Medicine. ..
  58. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  59. Ulcerative colitis-associated cancer and its prevention
    Guang Yu Yang; Fiscal Year: 2008
    ..This concept will be investigated using our UC-Ca model as well as using Ogg1 knockout mice. ..
  60. NQO1 Inhibitors and Pancreatic Cancer Therapy
    David Ross; Fiscal Year: 2008
    ..This approach represents a novel therapeutic strategy for the treatment of pancreatic cancer, a disease where therapeutic options are very limited and where chemotherapy has made minimal impact. ..