epoxide hydrolases

Summary

Summary: Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively. EC 3.3.2.3.

Top Publications

  1. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
  2. pmc Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis
    Xiang Li
    Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Sino France Joint Center for Drug Research and Screening, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 6:e14749. 2011
  3. pmc Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk
    Sean P Cleary
    Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 172:1000-14. 2010
  4. doi Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia
    Le Ning Zhang
    Arete Therapeutics Inc, 3912 Trust Way, Hayward, CA 94545, USA
    Arterioscler Thromb Vasc Biol 29:1265-70. 2009
  5. pmc Soluble epoxide hydrolase is a therapeutic target for acute inflammation
    Kara R Schmelzer
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:9772-7. 2005
  6. ncbi Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
  7. ncbi Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
    Peter C Rudberg
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 279:27376-82. 2004
  8. pmc Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels
    Jeffrey J Iliff
    Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Am J Physiol Heart Circ Physiol 296:H1352-63. 2009
  9. doi Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
    Le Ning Zhang
    Arete Therapeutics Inc, South San Francisco, CA 94080, USA
    Eur J Pharmacol 654:68-74. 2011
  10. pmc Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
    Pengcheng Luo
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 334:430-8. 2010

Research Grants

Detail Information

Publications289 found, 100 shown here

  1. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
    ..Our results suggest conserved roles for balanced eicosanoid production in vertebrate resistance to mycobacterial infection...
  2. pmc Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis
    Xiang Li
    Key Laboratory of Molecular Biophysics of Ministry of Education, School of Life Science and Technology, Sino France Joint Center for Drug Research and Screening, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 6:e14749. 2011
    ..Two functional polymorphisms in the EPHX1 gene, Tyr113His and His139Arg can alter the enzyme activity, suggesting their possible association with carcinogenesis risk, particularly of some tobacco-related cancers...
  3. pmc Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk
    Sean P Cleary
    Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 172:1000-14. 2010
    ..03) status. These findings support the hypothesis that prolonged cigarette smoking is associated with increased risk of colorectal cancer and that this risk may be modified by variation in carcinogen metabolism genes...
  4. doi Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia
    Le Ning Zhang
    Arete Therapeutics Inc, 3912 Trust Way, Hayward, CA 94545, USA
    Arterioscler Thromb Vasc Biol 29:1265-70. 2009
    ..Thus, inhibition of s-EH can prevent degradation of EETs and prolong their effects. The present study aimed to test the hypothesis that inhibition of s-EH has vascular protective effects...
  5. pmc Soluble epoxide hydrolase is a therapeutic target for acute inflammation
    Kara R Schmelzer
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:9772-7. 2005
    ..These data suggest that sEH inhibitors have therapeutic efficacy in the treatment and management of acute inflammatory diseases...
  6. ncbi Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  7. ncbi Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
    Peter C Rudberg
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 279:27376-82. 2004
    ..In conclusion, Arg(563) and Lys(565) possess distinct roles as carboxylate recognition sites for two chemically different substrates, each of which is turned over in separate enzymatic reactions catalyzed by LTA(4) hydrolase...
  8. pmc Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels
    Jeffrey J Iliff
    Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Am J Physiol Heart Circ Physiol 296:H1352-63. 2009
    ..The findings have important implications to such clinical conditions as migraine, vasospasm after subarachnoid hemorrhage, and stroke...
  9. doi Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
    Le Ning Zhang
    Arete Therapeutics Inc, South San Francisco, CA 94080, USA
    Eur J Pharmacol 654:68-74. 2011
    ..Thus, preserving vasodilator EETs by inhibition of s-EH may be of therapeutic benefit by improving endothelial function in cardiometabolic diseases...
  10. pmc Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis
    Pengcheng Luo
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 334:430-8. 2010
    ..These results show not only that sEH KO and its inhibition prevent hyperglycemia in diabetes, but also that sEH KO enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes...
  11. pmc Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
    Douglas R Davies
    deCODE BioStructures, Inc, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA
    J Med Chem 52:4694-715. 2009
    ..Analysis of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chemical features and binding modes of several reported LTA4H inhibitors...
  12. doi Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase
    Sundarapandian Thangapandian
    Division of Applied Life Science, BK21 Program, Environmental Biotechnology National Core Research Center, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, 900 Gazwa dong, Jinju 660 701, Republic of Korea
    J Chem Inf Model 51:33-44. 2011
    ..Reverse validation was performed to ensure the results of the study...
  13. ncbi Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population
    Ivona Hlavata
    Toxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic
    Oncol Rep 24:1347-53. 2010
    ..These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis...
  14. ncbi Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk
    Jordi To-Figueras
    Toxicology Unit, ORL Unit, Hospital Clinic, IDIBAPS, Ciutat Sanitaria de Bellvitge, Departament de Salut Publica, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cancer Lett 187:95-101. 2002
    ..173 (2001) 155) suggesting the existence of an interaction between variants of EH and GSTpi, both enzymes being involved in the metabolism of aromatic hydrocarbons, that may increase susceptibility to tobacco-related cancers...
  15. doi Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk
    Emma L Northwood
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital
    Pharmacogenet Genomics 20:315-26. 2010
    ....
  16. ncbi Epoxide hydrolases: their roles and interactions with lipid metabolism
    John W Newman
    Department of Entomology, UCDavis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Prog Lipid Res 44:1-51. 2005
    The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform epoxide containing lipids by the addition of water...
  17. ncbi Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1
    J Brøgger
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Helse Bergen HF, Jonas Liesv 65, Bergen N 5021, Norway
    Eur Respir J 27:682-8. 2006
    ..In conclusion, the present data and meta-analysis support a role for microsomal epoxide hydroxylase in the aetiology of chronic obstructive pulmonary disease...
  18. ncbi Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
    C J Sinal
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:40504-10. 2000
    ..These data provide the first direct evidence for a role for soluble epoxide hydrolase in blood pressure regulation and identify this enzyme as a novel and attractive target for therapeutic intervention in hypertension...
  19. pmc Soluble epoxide hydrolase: a novel therapeutic target in stroke
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:1931-40. 2007
    ..The findings suggest that sEH inhibition is protective against ischemic injury by non-vascular mechanisms, and that sEH may serve as a therapeutic target in stroke...
  20. pmc Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Prostaglandins Other Lipid Mediat 82:50-9. 2007
    ..A better understanding of these relationships will facilitate identification of novel targets for the prevention and/or treatment of ischemic heart disease, a major worldwide public health problem...
  21. doi Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors
    Philippe de Medina
    Institut National de la Santé et de la Recherche Médicale U 563, Toulouse, France
    Mol Pharmacol 78:827-36. 2010
    ..We further established that these effects correlated well with the control of growth and invasiveness of tumor cells. Our data shed light on the molecular mechanism underlying the anticancer and chemopreventive effects of auraptene...
  22. doi 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase
    Caroline Morin
    Le Bilarium, Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 Canada
    Am J Respir Cell Mol Biol 43:564-75. 2010
    ..These results demonstrate that 17,18-EpETE is a potent regulator of human lung inflammation and concomitant hyperresponsiveness, and may represent a valuable asset against critical inflammatory bronchial disorder...
  23. pmc Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
    Matthew L Edin
    Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 25:3436-47. 2011
    ..These data demonstrate that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R...
  24. ncbi Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury
    Ines P Koerner
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 27:4642-9. 2007
    ..The findings suggest that human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome...
  25. ncbi Insights into the reaction mechanism of soluble epoxide hydrolase from theoretical active site mutants
    Kathrin H Hopmann
    Department of Theoretical Chemistry, School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    J Phys Chem B 110:21299-310. 2006
    ..calculations of active site mutants are used to gain insights into the reaction mechanism of the soluble epoxide hydrolases (sEHs)...
  26. ncbi The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
    J W Holloway
    Divisios of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Allergy 63:1046-53. 2008
    ..Single nucleotide polymorphism (SNPs) and haplotypes spanning the LTA4H and ALOX5AP genes have been associated with LTB(4) production and myocardial infarction (MI)...
  27. pmc The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
    Annette Cronin
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:1552-7. 2003
    ..Thus, we propose this domain participates instead in the regulation of the physiological functions associated with sEH...
  28. ncbi The telltale structures of epoxide hydrolases
    Michael Arand
    Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany
    Drug Metab Rev 35:365-83. 2003
    Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds...
  29. pmc Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase
    Sung Hee Hwang
    Department of Entomology, University of California, Davis, California 95616 8584, United States
    J Med Chem 54:3037-50. 2011
    ..Thus, these novel dual inhibitors exhibited enhanced in vivo antiallodynic activity in a nociceptive behavioral assay...
  30. ncbi Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India
    DNA Cell Biol 28:573-7. 2009
    ..Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28). mEPHX haplotypes shared a positive association with HCC risk in India...
  31. pmc Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
    Abishek Iyer
    School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia
    Exp Diabetes Res 2012:758614. 2012
    ..The present study describes the pharmacological responses to this selective sEH inhibitor in rats with the signs of diet-induced metabolic syndrome...
  32. ncbi Reaction mechanism of soluble epoxide hydrolase: insights from molecular dynamics simulations
    Birgit Schiøtt
    Department of Chemistry, Aarhus University, 8000 Aarhus, Denmark
    J Am Chem Soc 124:14558-70. 2002
    ..This overall anti-correlated collective domain motion is, perhaps, involved in the conversion of E.NAC to E.TS...
  33. pmc Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP
    Bora Inceoglu
    Department of Entomology and University of California Davis Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:5093-7. 2011
    ..The cross-talk between the two major pathways-one mediated by cAMP and the other by EFAs-paves the way to new approaches to understand and control pain...
  34. doi EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians
    Polat Dura
    Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands
    Oncol Rep 27:1710-6. 2012
    ..In conclusion, the polymorphisms in exon 3 and exon 4 of the EPHX1 gene do not seem to be modifiers of esophageal squamous cell carcinoma or esophageal adenocarcinoma risk in Dutch Caucasians...
  35. pmc Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Carcinog 50:397-402. 2011
    ..11, 95% CI: 1.00-1.23, P = 0.04). These findings are consistent with prior studies implicating these genes in carcinogenesis and suggest that this collection of variants is worthy of follow-up in additional studies...
  36. ncbi Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    Vincent Sandanayaka
    Medicinal Chemistry, deCODE Chemistry, Inc, 2501 Davey Road, Woodridge, Illinois 60517, USA
    J Med Chem 53:573-85. 2010
    ..This is the first example of a gene-to-clinic paradigm enabled by a fragment-based drug discovery effort...
  37. ncbi A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  38. ncbi Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma
    Armando G Amador
    Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis 46202 5186, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:440-5. 2002
    ..The objective was to determine the prevalence of the polymorphisms of the microsomal epoxide hydrolase (Ephx1), glutathione S-transferase mu1 (GSTM ), theta1 (GSTT1), and pi1 (GSTP1) genes in patients with oropharyngeal carcinoma...
  39. pmc The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
    John W Newman
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 100:1558-63. 2003
    ..35 +/- 0.01 s(-1). Therefore dihydroxy lipid phosphates are possible candidates for the endogenous substrates of the sEH N-terminal domain, which would represent a novel branch of fatty acid metabolism with potential signaling functions...
  40. ncbi Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study
    Panagiota N Mitrou
    Dunn Human Nutrition Unit, MRC Wellcome Trust Building, Hills Road, Cambridge CB2 2XY, UK
    Carcinogenesis 28:875-82. 2007
    ..Alcohol increases risk of colorectal adenoma in carriers of the high-activity genotype possibly through enhanced activation of alcohol-related procarcinogens...
  41. ncbi Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer
    Meenu Jain
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India
    Toxicol Appl Pharmacol 230:247-51. 2008
    ..However, His139Arg genotype of exon 4, exhibited low risk for ESCC as well as its clinical characteristics...
  42. pmc Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways
    Bora Inceoglu
    Department of Entomology and UC Davis Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:18901-6. 2008
    ..Redirecting the flow of pronociceptive intracellular cAMP toward up-regulation of StARD1 mRNA by concomitantly elevating EETs is a novel path to accomplish pain relief in both inflammatory and neuropathic pain states...
  43. ncbi [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
    Chul Ho Jeong
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:5584-91. 2009
    ..Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer...
  44. pmc Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
    Marlina Manhiani
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 297:F740-8. 2009
    ..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension...
  45. ncbi Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases
    John D Imig
    Vascular Biology Ctr, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Renal Physiol 289:F496-503. 2005
    ..Thus the renal and cardiovascular protective actions of increasing epoxygenase levels could be translated to therapies for preventing end-organ damage...
  46. pmc Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance
    Ayala Luria
    Department of Entomology, Division of Nephrology, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:9038-43. 2011
    ..These observations were supported by pharmacological inhibition of sEH. These data suggest that an increase in EETs due to sEH-gene knockout leads to an increase in the size of islets and improved insulin signaling and sensitivity...
  47. pmc Development of a high-throughput screen for soluble epoxide hydrolase inhibition
    Nicola M Wolf
    Department of Plant Sciences, Center of Life Sciences Weihenstephan, Technische Universitat Munchen, 85350 Freising, Germany
    Anal Biochem 355:71-80. 2006
    ..7 proved the system's robustness and potential for HTS. The developed assay system will be a valuable tool to discover new structures for the therapeutic inhibition of sEH to treat various cardiovascular diseases...
  48. pmc Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
    Jun Yan Liu
    Department of Entomology and UCD Cancer Research Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Pharmacol 156:284-96. 2009
    ..Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI...
  49. doi SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan
    Ling I Hsu
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Toxicol Appl Pharmacol 228:144-55. 2008
    ..These observations implied that impaired metabolism of carcinogenic exposure as well as impaired DNA repair function play an important role in arsenic-related urinary transitional cell carcinogenesis...
  50. ncbi Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia
    Carlos H Sierra-Torres
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
    Environ Mol Mutagen 41:69-76. 2003
    ..Further studies using larger populations will be needed to confirm our observations and to validate data for disease prevention...
  51. ncbi Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China
    L Yin
    School of Public Health, Southeast University, Nanjing, PR China
    Lung Cancer 33:133-41. 2001
    ..71-18.68). The association was also found with squamous cell carcinoma (OR, 3.23; 95% CI, 1.00-10.38). Our results suggest that HYL1*2 polymorphism might be a risk factor for smoking-associated lung cancer in China...
  52. doi The role of epoxide hydrolase Y113H gene variant in pancreatic diseases
    Johann Ockenga
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Germany
    Pancreas 38:e97-e101. 2009
    ..We studied the role of the EPHX1 c.337T>C (p.Y113H) variant, whichleads to altered enzyme activity, in pancreatic diseases...
  53. ncbi Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India
    Rakhshan Ihsan
    Institute of Pathology, New Delhi, India
    J Gastroenterol Hepatol 25:1456-62. 2010
    ....
  54. ncbi Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
    Elise M J van der Logt
    Department of Gastroenterology, University Medical Centre, St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mutat Res 593:39-49. 2006
    ..In conclusion, these data suggest that the presence of variant NQO1 genotypes, with expected reduced enzyme activities might enhance susceptibility to CRC...
  55. pmc Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
    John D Imig
    Department of Pharmacology and Toxicology, Cardiovascular Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Drug Discov 8:794-805. 2009
    ....
  56. pmc Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    Hong Qiu
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8161-6. 2006
    ..The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis...
  57. pmc Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia
    Wenri Zhang
    Oregon Health and Science University, Department of Anesthesiology and Peri Operative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Stroke 39:2073-8. 2008
    ..We tested the hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow...
  58. doi Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design
    Fredrik Tholander
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institute, Stockholm, Sweden
    Chem Biol 15:920-9. 2008
    ..Our data provide detailed insights to the active site chemistry of M1 aminopeptidases and will aid in the development of novel enzyme inhibitors...
  59. pmc Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Circ Res 99:442-50. 2006
    ..Together, these data suggest that targeted disruption of sEH increases the availability of cardioprotective EETs that work by activating PI3K signaling pathways and K+ channels...
  60. ncbi Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
    John D Imig
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 39:690-4. 2002
    ..Moreover, sEH plays a role in the regulation of blood pressure, and inhibition of sEH during Ang II hypertension is antihypertensive...
  61. pmc Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
    Danyan Xu
    Division of Cardiovascular Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:18733-8. 2006
    ..We conclude that the use of sEHIs to increase the level of the endogenous lipid epoxides such as EETs may represent a viable and completely unexplored avenue to reduce cardiac hypertrophy by blocking NF-kappaB activation...
  62. ncbi CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer
    Stefania Boccia
    Genetic Epidemiology and Molecular Biology Unit, Institute of Hygiene, Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
    J Cancer Res Clin Oncol 134:93-100. 2008
    ..As risk-modifiers of alcohol and tobacco effects, metabolic genes polymorphisms were investigated as susceptibility candidates for squamous cell carcinoma of the head and neck (SCCHN)...
  63. ncbi Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary
    Istvan Kiss
    Department of Preventive Medicine, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 27:2931-7. 2007
    ....
  64. doi Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    DNA Cell Biol 27:687-94. 2008
    ..GST and mEPHX variants share a positive association with viral-related HCC risk in Indian population, although a larger sample size is still required to confirm the results...
  65. doi Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors
    Sundarapandian Thangapandian
    Division of Applied Life Science BK21 program, Environmental Biotechnology National Core Research Center EB NCRC, Gyeongsang National University GNU, 900 Gazwa dong, Jinju 660 701, Republic of Korea
    Eur J Med Chem 46:1593-603. 2011
    ..Molecular docking study was employed to identify the compounds that bind the active site with high affinity. Developed Bayesian model suggested molecular features favoring and not favoring the inhibition of hLTA4H...
  66. pmc Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids
    Christophe Morisseau
    Department of Entomology and Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    J Lipid Res 51:3481-90. 2010
    ..Consequently, the DHA and eicosapentaenoic acid epoxides may be responsible for some of the beneficial effects associated with dietary n-3 fatty acid intake...
  67. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..This data suggests that heterocyclic amines do not play an important role in the aetiology of colorectal cancer but that exposure to other carcinogens such as polycyclic aromatic hydrocarbons may be important determinants of cancer risk...
  68. ncbi Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
    Xueying Zhao
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
    J Am Soc Nephrol 15:1244-53. 2004
    ..These data demonstrate that SEH inhibition has antihypertensive and renal vascular protective effects in angiotensin hypertension and suggests that SEH inhibitors may be a useful therapeutic intervention for cardiovascular diseases...
  69. ncbi Structures and mechanisms of enzymes in the leukotriene cascade
    Agnes Rinaldo-Matthis
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochimie 92:676-81. 2010
    ..This chapter reviews the biochemistry, catalytic, and structural properties of the enzymes in the leukotriene cascade...
  70. doi Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage
    Manfred T Reetz
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, D 45470 Mulheim Ruhr, Germany
    J Am Chem Soc 131:7334-43. 2009
    ..Predictions regarding substrate scope and enantioselectivity of the best mutant are shown to be possible...
  71. ncbi Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India
    Daya Shankar Srivastava
    Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India
    Arch Toxicol 82:633-9. 2008
    ..No associations were observed with stage or grade of bladder tumor with these genotypes. In conclusion, our study demonstrated that exon 3 His genotype of the mEH are more prone to the risk of sporadic bladder cancer in North India...
  72. pmc Expression and regulation of soluble epoxide hydrolase in adipose tissue
    Bart M De Taeye
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:489-98. 2010
    ....
  73. pmc Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation
    Benjamin B Davis
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 99:2222-7. 2002
    ..Metabolism of these compounds by epoxide hydrolases results in the formation of compounds that affect the vasculature in a pleiotropic manner...
  74. ncbi EPHX1 gene polymorphisms and individual susceptibility to lung cancer
    Anu Voho
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Cancer Lett 237:102-8. 2006
    ..Neither was any difference seen in the prevalence of the EPHX1 Tyr113His genotypes or interpreted EPHX1 phenotypes in the different age groups...
  75. pmc Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain
    Bora Inceoglu
    Department of Entomology, University of California Davis Cancer Center, One Shields Avenue, Davis, CA 95616, United States
    Life Sci 79:2311-9. 2006
    Soluble epoxide hydrolases catalyze the hydrolysis of epoxides in acyclic systems. In man this enzyme is the product of a single copy gene (EPXH-2) present on chromosome 8...
  76. ncbi Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase
    T Shimada
    Osaka Prefectural Institute of Public Health, 3 69 Nakamichi 1 chome, Higashinari ku, Osaka 537, Japan
    Chem Res Toxicol 12:623-9. 1999
    ....
  77. pmc Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1475-81. 2009
    ..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...
  78. pmc Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design
    Sundarapandian Thangapandian
    Division of Applied Life Science, BK21 Program, Systems and Synthetic Agrobiotech Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea
    PLoS ONE 7:e34593. 2012
    ..Final evaluation based on molecular docking and electronic parameters has identified three compounds of diverse chemical scaffolds as potential leads to be used in novel and potent hLTA4H inhibitor design...
  79. pmc Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 21:615-23. 2011
    ..To explore associations with prostate cancer and farming, it is important to investigate the relationship between pesticide use and single nucleotide polymorphisms (SNPs) in xenobiotic metabolic enzyme (XME) genes...
  80. ncbi Leukotriene A4 hydrolase: a zinc metalloenzyme
    J Z Haeggstrom
    Department of Physiological Chemistry, Karolinska Institute, Stockholm, Sweden
    Biochem Biophys Res Commun 172:965-70. 1990
    ..The catalytic activity is almost completely restored by the addition of stoichiometric amounts of Zn2+ or Co2+...
  81. ncbi Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function
    Arthur A Spector
    Department of Biochemistry, 4 403 Bowen Science Building, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Prog Lipid Res 43:55-90. 2004
    ..Because of the diversity of biochemical and functional responses produced by EETs, it is doubtful that a single mechanism or signal transduction pathway can account for all of their actions...
  82. ncbi Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:2612-8. 2007
    ..Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells...
  83. ncbi Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans
    T H Faller
    , Neuherberg, Germany
    Toxicol Appl Pharmacol 172:62-74. 2001
    ..Species-specific EH activities in lung were similar to those in liver. In rat nasal mucosa, GST and EH activities were much higher than in rat liver...
  84. pmc Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
    In Hae Kim
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Bioorg Med Chem 15:312-23. 2007
    ..The esterification of 1 results in compounds that are easier to formulate in animal food and in triglycerides for gavage and other routes of administration, making it easier to study the biological effects of sEH inhibition in vivo...
  85. doi Temperature and pH dependence of enzyme-catalyzed hydrolysis of trans-methylstyrene oxide. A unifying kinetic model for observed hysteresis, cooperativity, and regioselectivity
    Diana Lindberg
    Department of Biochemistry and Organic Chemistry, Uppsala University, BMC, Box 576, SE 751 23 Uppsala, Sweden
    Biochemistry 49:2297-304. 2010
    The underlying enzyme kinetics behind the regioselective promiscuity shown by epoxide hydrolases toward certain epoxides has been studied...
  86. ncbi Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis
    Xiaolu Jiang
    College of Chemistry and Molecular Engineering, Peking University, People s Republic of China
    Chembiochem 11:1120-8. 2010
    ..F314E behaves as a highly selective aminopeptidase towards arginyl peptides with a selectivity increase of 850-fold, whereas V367W prefers alanyl peptides over arginyl peptides, just as the organic modulators do...
  87. doi Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors
    Hiroshi Enomoto
    Nara Research and Development Center, Santen Pharmaceutical Co, Ltd, 8916 16 Takayama cho, Ikoma shi, Nara 630 0101, Japan
    Bioorg Med Chem Lett 19:442-6. 2009
    ..Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA(4) hydrolase inhibitors...
  88. ncbi Theoretical study of the full reaction mechanism of human soluble epoxide hydrolase
    Kathrin H Hopmann
    Department of Theoretical Chemistry, School of Biotechnology, Royal Institute of Technology, AlbaNova University Center, SE 106 91 Stockholm, Sweden
    Chemistry 12:6898-909. 2006
    ..b>Epoxide hydrolases catalyze the conversion of epoxides to their corresponding vicinal diols...
  89. ncbi Computational study of phosphatase activity in soluble epoxide hydrolase: high efficiency through a water bridge mediated proton shuttle
    Marco De Vivo
    Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    J Am Chem Soc 127:11226-7. 2005
    ..The calculated free energy of the favored catalytic pathway is approximately 19 kcal/mol, in excellent agreement with experimental data...
  90. pmc Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice
    Ayala Luria
    Department of Entomology, University of California, Davis, CA 95616, USA
    J Biol Chem 282:2891-8. 2007
    ..This shift in renal metabolism is likely a metabolic compensation for the loss of the soluble epoxide hydrolase gene...
  91. ncbi Synthetic applications of epoxide hydrolases
    A Archelas
    Groupe Biocatalyse et Chimie Fine, UMR CNRS 6111, Universite de la Mediterranee, Faculte des Sciences de Luminy, Marseille, France
    Curr Opin Chem Biol 5:112-9. 2001
    ..e. epoxide hydrolases)...
  92. ncbi Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
    German A Gomez
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    Biochemistry 43:4716-23. 2004
    ..Natl. Acad. Sci. U.S.A. 100, 1558-1563]. The binding of Mg(2+)-HPO4(2-) to the N-terminal domain of human sEH in its CIU complex reveals structural features relevant to those of the enzyme-substrate complex in the phosphatase reaction...
  93. pmc Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk
    J Y Park
    Division of Cancer Prevention and Control, 12902 Magnolia Drive, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Eur J Cancer Prev 14:223-30. 2005
    ..This association was more pronounced among patients with lung adenocarcinoma (OR 4.7, 95% CI 1.7-13.1). These results suggest that the EH polymorphism plays an important role in lung cancer risk and is linked to tobacco smoke exposure...
  94. ncbi The microsomal epoxide hydrolase Tyr113His polymorphism: association with risk of ovarian cancer
    A B Spurdle
    Oncology Division, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research and The University of Queensland, Herston, PO Royal Brisbane Hospital, Queensland, Australia
    Mol Carcinog 30:71-8. 2001
    ..Mol. Carcinog. 30:71-78, 2001...
  95. ncbi Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer
    Nohelia Cajas-Salazar
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Cancer Genet Cytogenet 145:97-102. 2003
    ..In conclusion, the CA data provides evidence to support that susceptibility mEH alleles are significantly involved with the development of lung cancer from cigarette smoking...
  96. doi Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series
    Claudio Graziano
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Lung Cancer 63:187-93. 2009
    ..23, p=0.007). This analysis of lung cancer in subjects under age 45 supports the hypothesis that EPHX1 polymorphisms may have a role in cancer susceptibility in this age group...
  97. ncbi Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population
    N A Wong
    Department of Pathology, University of Edinburgh Medical School, UK
    Toxicol Lett 115:17-22. 2000
    ....
  98. pmc Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk
    A Gsur
    Division of Applied and Experimental Oncology, Institute of Cancer Research, University of Vienna, Austria
    Br J Cancer 89:702-6. 2003
    ..The adjusted OR, calculated relative to the His139/His139 wild type, was for the Arg139/Arg139 genotype 1.83 (0.76-4.44). Our results support the hypothesis that genetically reduced mEH activity may be protective against lung cancer...
  99. ncbi Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis
    D C Zeldin
    Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37236
    Arch Biochem Biophys 316:443-51. 1995
    ..abstract truncated at 400 words)..
  100. pmc Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
    Sung Hee Hwang
    Department of Entomology and UCD Cancer Center, University of California, One Shields Avenue, Davis, CA 95616 8584, USA
    Bioorg Med Chem Lett 16:5773-7. 2006
    ....
  101. ncbi Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children
    Vanessa da Silva Silveira
    Department of Genetics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Environ Mol Mutagen 51:48-56. 2010
    ....

Research Grants70

  1. Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Mary Jackson; Fiscal Year: 2009
    ..The genome of M. tb potentially encodes seven proteins related to epoxide hydrolases, some of which appear to be involved in the introduction of functional groups in mycolic acids and to be ..
  2. Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Mary Jackson; Fiscal Year: 2010
    ..The genome of M. tb potentially encodes seven proteins related to epoxide hydrolases, some of which appear to be involved in the introduction of functional groups in mycolic acids and to be ..
  3. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2000
    ....
  4. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ....
  5. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 1999
    ....
  6. LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTION
    EDWARD GOETZL; Fiscal Year: 1990
    ..The major objectives are the definition of the enzymatic properties of lipoxygenases and epoxide hydrolases of murine mast cells and human leukocytes and the characterization of the modlecular bases for cellular ..
  7. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2004
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  8. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2000
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  9. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2001
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  10. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2005
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  11. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2006
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  12. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2003
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  13. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 1999
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  14. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2007
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  15. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2002
    ..This proposal targets two enzyme classes, epoxide hydrolases (EHs) and esterases, which are both members of the alpha/beta-hydrolase fold family...
  16. CRUCIFEROUS VEGETABLES, GENES, AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 1999
    ..The enzymes are called glutathione transferase, glucuronosyltransferases, quinone reductases, and epoxide hydrolases. Special compounds in broccoli raise the levels of these enzymes in the body...
  17. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2002
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  18. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2004
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  19. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2001
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  20. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2000
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  21. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2003
    ..The EETs are further metabolized by epoxide hydrolases to the corresponding dihydroxyeicosatrienoic acids (DHETs)...
  22. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  23. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2003
    ..abstract_text> ..
  24. Identification of novel therapeutic approaches for TETS and OP intoxication
    Michael A Rogawski; Fiscal Year: 2010
    ..this research project is to test the hypothesis that AMPA receptor antagonists and/or inhibitors of soluble epoxide hydrolases will significantly improve outcome following exposure to acutely toxic levels of TETS and parathion by ..
  25. STRUCTURE AND FUNCTION OF MEMBRANE TRANSPORT PROTEINS
    Daniel Levy; Fiscal Year: 2002
    ..These studies should substantially increase out knowledge of this important transport system which plays a critical role in numerous physiological processes and in the etiology of several major diseases. ..
  26. STRUCTURE AND FUNCTION OF MEMBRANE TRANSPORT PROTEINS
    Daniel Levy; Fiscal Year: 2001
    ..These studies should substantially increase out knowledge of this important transport system which plays a critical role in numerous physiological processes and in the etiology of several major diseases. ..
  27. STRUCTURE AND FUNCTION OF MEMBRANE TRANSPORT PROTEINS
    Daniel Levy; Fiscal Year: 2000
    ..These studies should substantially increase out knowledge of this important transport system which plays a critical role in numerous physiological processes and in the etiology of several major diseases. ..
  28. STRUCTURE AND FUNCTION OF MEMBRANE TRANSPORT PROTEINS
    Daniel Levy; Fiscal Year: 2003
    ..These studies should substantially increase out knowledge of this important transport system which plays a critical role in numerous physiological processes and in the etiology of several major diseases. ..
  29. Benzo(a) pyrene Metabolism--Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2001
    ....
  30. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1993
    ..the metabolic activation of naphthalene to epoxides, b) increased protection afforded by increases in epoxide hydrolases or glutathione transferases capable of rapid conversion of the epoxides to diols/conjugates, c) decreased ..
  31. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1992
    ..the metabolic activation of naphthalene to epoxides, b) increased protection afforded by increases in epoxide hydrolases or glutathione transferases capable of rapid conversion of the epoxides to diols/conjugates, c) decreased ..
  32. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce Hammock; Fiscal Year: 2009
    ..A set of under-studied metabolic enzymes include the epoxide hydrolases in the ?/?-hydrolase fold family. These enzymes degrade epoxides by adding water...
  33. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce D Hammock; Fiscal Year: 2010
    ..A set of under-studied metabolic enzymes include the epoxide hydrolases in the ?/?-hydrolase fold family. These enzymes degrade epoxides by adding water...
  34. PROSTATIC GLUTATHIONE S-EPOXIDE TRANSFERASES
    CARL SCHAFFNER; Fiscal Year: 1990
    ..5.1.18) and epoxide hydrolases (EC 3.3.2.3) as isoenzymes will be examined in detail...
  35. Radiation Sensitivity, DNA Repair and Second Cancers
    Debra Friedman; Fiscal Year: 2007
    ..abstract_text> ..
  36. Radiation Sensitivity, DNA Repair and Second Cancers
    Debra Friedman; Fiscal Year: 2005
    ..abstract_text> ..
  37. Radiation Sensitivity, DNA Repair and Second Cancers
    Debra Friedman; Fiscal Year: 2004
    ..abstract_text> ..
  38. Radiation Sensitivity, DNA Repair and Second Cancers
    Debra Friedman; Fiscal Year: 2006
    ..abstract_text> ..
  39. HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
    Jonathan Ward; Fiscal Year: 2005
    ..how genetic variation in mEH influences human sensitivity to the genotoxic effects of BD, and better understand the role of variants in biotransformation genes in modifying human susceptibility to toxic chemicals ..
  40. HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
    Jonathan Ward; Fiscal Year: 2004
    ..how genetic variation in mEH influences human sensitivity to the genotoxic effects of BD, and better understand the role of variants in biotransformation genes in modifying human susceptibility to toxic chemicals ..
  41. HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
    Jonathan Ward; Fiscal Year: 2002
    ..how genetic variation in mEH influences human sensitivity to the genotoxic effects of BD, and better understand the role of variants in biotransformation genes in modifying human susceptibility to toxic chemicals ..
  42. HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
    Jonathan Ward; Fiscal Year: 2003
    ..how genetic variation in mEH influences human sensitivity to the genotoxic effects of BD, and better understand the role of variants in biotransformation genes in modifying human susceptibility to toxic chemicals ..
  43. Identification of Desaturase Targets
    Mary Jackson; Fiscal Year: 2007
    ..tuberculosis potentially encodes eleven proteins structurally related to mammalian-type epoxide hydrolases which are known in eukaryotes to be sensitive to urea inhibitors...
  44. Identification of Desaturase Targets
    Patrick Brennan; Fiscal Year: 2005
    ..tuberculosis potentially encodes eleven proteins structurally related to mammalian-type epoxide hydrolases which are known in eukaryotes to be sensitive to urea inhibitors...
  45. Identification of Desaturase Targets
    Patrick Brennan; Fiscal Year: 2006
    ..tuberculosis potentially encodes eleven proteins structurally related to mammalian-type epoxide hydrolases which are known in eukaryotes to be sensitive to urea inhibitors...
  46. Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase
    Daniel Levy; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase
    Daniel Levy; Fiscal Year: 2009
    ..abstract_text> ..
  48. Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase
    Daniel Levy; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  49. Function and Expression of the Bile Acid Transport Protein m-Epoxide Hydrolase
    DANIEL S LEVY; Fiscal Year: 2010
    ..abstract_text> ..
  50. XENOBIOTIC-METABOLIZING ENZYMES IN HUMAN LUNG
    Thomas Guenthner; Fiscal Year: 1990
    ..g. cytochrome P-450 isozymes or structurally unrelated epoxide hydrolases), and to variants of a single specific enzyme form (microsomal epoxide hydrolase)...
  51. EPOXIDE HYDROLASE STUDIES AND PHENYTOIN INDUCED CLEFTING
    James Hartsfield; Fiscal Year: 1999
    ..This may led to the consideration of alternative maternal anticonvulsant therapeutics. ..
  52. EPOXIDE HYDROLASE STUDIES AND PHENYTOIN INDUCED CLEFTING
    James Hartsfield; Fiscal Year: 2000
    ..This may led to the consideration of alternative maternal anticonvulsant therapeutics. ..
  53. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..The ultimate goal of this study is to determine whether or not these biomarkers can be useful as markers for risk assessment in humans exposed to PAHs at low ambient levels in future large scale epidemiological studies. ..
  54. MEMBRANE BOUND DETOXICATION ENZYMES
    Richard Armstrong; Fiscal Year: 2000
    ....
  55. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2002
    ..The ultimate goal of this study is to determine whether or not these biomarkers can be useful as markers for risk assessment in humans exposed to PAHs at low ambient levels in future large scale epidemiological studies. ..
  56. MEMBRANE BOUND DETOXICATION ENZYMES
    Richard Armstrong; Fiscal Year: 1999
    ....
  57. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2003
    ..The ultimate goal of this study is to determine whether or not these biomarkers can be useful as markers for risk assessment in humans exposed to PAHs at low ambient levels in future large scale epidemiological studies. ..
  58. MOLECULAR MECHANISMS OF EXPRESSION OF CYTOCHROME P-450
    CURTIS OMIECINSKI; Fiscal Year: 1991
    ..These investigations will provide a framework for determining the genetic basis underlying differential susceptibilities of individuals to the toxic effects associated with chemical exposures...
  59. MOLECULAR MECHANISMS OF EXPRESSION OF CYTOCHROME P-450
    CURTIS OMIECINSKI; Fiscal Year: 1992
    ..These investigations will provide a framework for determining the genetic basis underlying differential susceptibilities of individuals to the toxic effects associated with chemical exposures...
  60. MOLECULAR MECHANISMS OF EXPRESSION OF CYTOCHROME P-450
    CURTIS OMIECINSKI; Fiscal Year: 1993
    ..These investigations will provide a framework for determining the genetic basis underlying differential susceptibilities of individuals to the toxic effects associated with chemical exposures...
  61. Epoxide Hydrolases: Discovery and Synthetic Applications
    Lishan Zhao; Fiscal Year: 2003
    ..b>Epoxide hydrolases, which catalyze the hydrolysis of racemic epoxides to generate both the corresponding diols and the un-..
  62. Gene-Environment Interactions in RA Autoimmunity and Disease Severity
    Ted Mikuls; Fiscal Year: 2007
    ..We anticipate that the results of this study will be extended to other RA populations. ..
  63. Gene-Environment Interactions in RA Autoimmunity and Disease Severity
    Ted Mikuls; Fiscal Year: 2009
    ..We anticipate that the results of this study will be extended to other RA populations. ..
  64. Interindividual Variability in Human Microsomal Epoxide Hydrolase
    Curtis J Omiecinski; Fiscal Year: 2010
    ..This research program will characterize the critical features that account for these differences and investigate their roles as risk modifiers of human diseases. ..
  65. MULTIPLICITY OF HUMAN XENOBIOTIC-METABOLIZING ENZYMES
    Thomas Guenthner; Fiscal Year: 1990
    ..g. cytochrome P-450 isozymes or structurally unrelated epoxide hydrolases), and to variants of a single specific enzyme form (microsomal epoxide hydrolase)...
  66. Interindividual Variability in Human Microsomal Epoxide Hydrolase
    CURTIS OMIECINSKI; Fiscal Year: 2009
    ..This research program will characterize the critical features that account for these differences and investigate their roles as risk modifiers of human diseases. ..
  67. MOLECULAR TOXICOLOGY OF EPOXIDE HYDROLASE
    CURTIS OMIECINSKI; Fiscal Year: 1999
    ....
  68. MOLECULAR TOXICOLOGY OF EPOXIDE HYDROLASE
    CURTIS OMIECINSKI; Fiscal Year: 2002
    ....