prothrombin

Summary

Summary: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Top Publications

  1. ncbi Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases
    Elena Sokolova
    Otto von Guericke Universitaet Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, Leipziger Strasse 44, Magdeburg, Germany
    Thromb Haemost 100:576-81. 2008
  2. pmc Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    Jorge A Marrero
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Gastroenterology 137:110-8. 2009
  3. ncbi Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma
    G Bertino
    Department of Internal Medicine and Systemic Diseases, Catania University, Catania, Italy
    Minerva Med 102:363-71. 2011
  4. doi Prognostic and diagnostic value of des-γ-carboxy prothrombin in liver cancer
    Gaetano Bertino
    Department of Internal Medicine and Systemic Diseases, Santa Marta Hospital, Catania University, Catania, Italy
    Drug News Perspect 23:498-508. 2010
  5. ncbi Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, E1552 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 52:776-82. 2007
  6. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
  7. doi p38 MAPK controls prothrombin expression by regulated RNA 3' end processing
    Sven Danckwardt
    Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany
    Mol Cell 41:298-310. 2011
  8. ncbi Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues
    Jihong Liu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Urology 67:201-3. 2006
  9. doi Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
    Hyoung Su Kim
    Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
    J Clin Gastroenterol 43:482-8. 2009
  10. doi D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer: results from the Vienna Cancer and Thrombosis Study
    Cihan Ay
    Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer GuerA 1090 Vienna, Austria
    J Clin Oncol 27:4124-9. 2009

Research Grants

  1. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2010
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    Umesh Desai; Fiscal Year: 2009
  3. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2006
  4. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2003
  5. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2010
  6. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2010
  7. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2009
  8. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
  9. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
  10. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2010

Detail Information

Publications293 found, 100 shown here

  1. ncbi Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases
    Elena Sokolova
    Otto von Guericke Universitaet Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, Leipziger Strasse 44, Magdeburg, Germany
    Thromb Haemost 100:576-81. 2008
    ..Both prothrombin and its active form thrombin have been detected locally in the brain...
  2. pmc Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    Jorge A Marrero
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Gastroenterology 137:110-8. 2009
    ..Des-gamma carboxy-prothrombin (DCP) and lectin-bound AFP (AFP-L3%) are potential surveillance tests for HCC...
  3. ncbi Diagnostic and prognostic value of alpha-fetoprotein, des-γ-carboxy prothrombin and squamous cell carcinoma antigen immunoglobulin M complexes in hepatocellular carcinoma
    G Bertino
    Department of Internal Medicine and Systemic Diseases, Catania University, Catania, Italy
    Minerva Med 102:363-71. 2011
    ..The aim of this study was compare the accuracy of α-fetoprotein (AFP), des-γ- carboxy prothrombin (DCP), squamous cell carcinoma antigen-immunoglobulin M complexes (SCCA-IgM Cs) in the early diagnosis and in ..
  4. doi Prognostic and diagnostic value of des-γ-carboxy prothrombin in liver cancer
    Gaetano Bertino
    Department of Internal Medicine and Systemic Diseases, Santa Marta Hospital, Catania University, Catania, Italy
    Drug News Perspect 23:498-508. 2010
    Des-γ-carboxy prothrombin (DCP) is an abnormal prothrombin induced by the absence of vitamin K₂ that is increased in the serum of patients with hepatocellular carcinoma (HCC)...
  5. ncbi Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, E1552 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 52:776-82. 2007
    ..role for the lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3%) and des-gamma-carboxy prothrombin (DCP) in the management of the U.S. hepatocellular carcinoma (HCC) patient population...
  6. pmc Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    Herbert Schöchl
    Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
    Crit Care 14:R55. 2010
    ..The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates...
  7. doi p38 MAPK controls prothrombin expression by regulated RNA 3' end processing
    Sven Danckwardt
    Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany
    Mol Cell 41:298-310. 2011
    ..Although induced in many (patho-)physiological conditions, the underlying mechanisms controlling prothrombin expression remained enigmatic...
  8. ncbi Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues
    Jihong Liu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Urology 67:201-3. 2006
    To investigate the inhibitory role of gamma (gamma)-carboxyglutamic acid (Gla) in the Gla domain of urinary prothrombin in the formation of calcium oxalate crystals.
  9. doi Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
    Hyoung Su Kim
    Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
    J Clin Gastroenterol 43:482-8. 2009
    ..However, prognostic values of AFP and PIVKA-II remain clarified in hepatitis B virus (HBV)-associated HCC. This study was aimed to evaluate the prognostic values of AFP and PIVKA-II in HBV-associated HCC...
  10. doi D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer: results from the Vienna Cancer and Thrombosis Study
    Cihan Ay
    Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer GuerA 1090 Vienna, Austria
    J Clin Oncol 27:4124-9. 2009
    ..The aim of this study was to investigate D-dimer and prothrombin fragment 1 + 2 (F 1 + 2), which reflect activation of blood coagulation and fibrinolysis, for prediction of ..
  11. doi Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma
    Francisco A Durazo
    The Pfleger Liver Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Gastroenterol Hepatol 23:1541-8. 2008
    ....
  12. pmc Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma
    Kenichi Hakamada
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    World J Gastroenterol 14:1370-7. 2008
    To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma.
  13. pmc Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e623. 2007
    ..We have shown that MASP2 is capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin...
  14. doi Prevalence of angiotensin-converting enzyme, methylenetetrahydrofolate reductase, Factor V Leiden, prothrombin and apolipoprotein E gene polymorphisms in Morocco
    Thierry Paluku They-They
    Laboratoire de Génétique Médicale et Pathologie Moléculaire LGPM, Faculté de Médecine et de Pharmacie Casablanca, 19 rue Tarik Ibn Ziad, Casablanca, Morocco
    Ann Hum Biol 37:767-77. 2010
    ..These genetic factors are involved in several pathways affecting blood pressure regulation, blood coagulation, homocysteine and lipid metabolisms...
  15. ncbi Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs
    Wassim Y Almawi
    Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
    J Thromb Thrombolysis 20:163-8. 2005
    Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) are major inherited risk factors of venous thromboembolism...
  16. ncbi A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    S R Poort
    Hemostasis and Thrombosis Research Center, Leiden University Hospital, The Netherlands
    Blood 88:3698-703. 1996
    We have examined the prothrombin gene as a candidate gene for venous thrombosis in selected patients with a documented familial history of venous thrombophilia...
  17. ncbi Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma
    Shigetoshi Fujiyama
    Third Department of Internal Medicine, Kumamoto University School of Medicine, Japan
    Oncology 62:57-63. 2002
    ..Equally important in the management of patients with HCC are biological indicators for malignancy, the selection of therapeutic interventions and the prediction of the outcome...
  18. doi Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma
    Richard K Sterling
    Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:104-13. 2009
    Des-gamma-carboxy prothrombin (DCP) and Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) are surveillance markers used to detect hepatocellular carcinoma (HCC) in Japan...
  19. doi Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway
    Ziqiu Wang
    Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 216:551-7. 2008
    We have previously shown that prothrombin, a blood coagulation factor, can cause an inhibition of DNA synthesis in normal rat hepatocytes...
  20. ncbi Effects of Mucuna pruriens extract on activation of prothrombin by Echis carinatus venom
    R Guerranti
    Institute of Biochemistry and Enzymology, University of Siena, Via A Moro, 53100, Siena, Italy
    J Ethnopharmacol 75:175-80. 2001
    ..Here the effect of an extract of MP101UJ in prothrombin activation by EV in vitro by clotting and chromogenic assay is studied...
  21. ncbi Glycosylation of prothrombin fragment 1 governs calcium oxalate crystal nucleation and aggregation, but not crystal growth
    Dawn Webber
    Department of Chemistry, University of Cape Town, Private Bag, Rondebosch, Cape Town, 7701, South Africa
    Urol Res 35:277-85. 2007
    ..In several cases, this has been attributed to glycosylation of the proteins as evidenced by urinary prothrombin fragment 1 where there is a correlation between sialylation and calcium oxalate kidney stone disease...
  22. ncbi Renal prothrombin mRNA is significantly decreased in a hyperoxaluric rat model of nephrolithiasis
    P K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre and Flinders University Bedford Park 5042, South Australia, Australia
    J Pathol 210:273-81. 2006
    Although urinary prothrombin fragment 1 (UPTF1) possesses several hallmarks expected of a regulatory protein in urolithiasis, its precise role remains unknown...
  23. pmc In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
    Peter Panizzi
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1142-6. 2011
    ..Here we report that an engineered analog of prothrombin could be used to detect S...
  24. ncbi Plasma levels of plasminogen activator inhibitor type 1, factor VIII, prothrombin activation fragment 1+2, anticardiolipin, and antiprothrombin antibodies are risk factors for thrombosis in hemodialysis patients
    Daniela Molino
    Divison of Nephrology, Second University of Naples, Naples, Italy
    Semin Nephrol 24:495-501. 2004
    ..All patients underwent a screening prothrombin time, activated partial thromboplastin time, fibrinogen (Fg), coagulation factors of the intrinsic and ..
  25. ncbi EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro
    H Ireland
    Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
    Atherosclerosis 183:283-92. 2005
    ..Furthermore, in base-line samples from NPHSII and in the diabetic study, a significant increase in prothrombin F1+2 level was observed for 219Gly...
  26. ncbi Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia
    N H Gehring
    Department of Pediatrics, , Humboldt University, Berlin, Germany
    Nat Genet 28:389-92. 2001
    The G-->A mutation at position 20210 of the prothrombin or coagulation factor II gene (F2) represents a common genetic risk factor for the occurrence of thromboembolic events...
  27. ncbi Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001
    ..69). Conversely, factor II G20210A mutation was equally balanced in both patient groups...
  28. pmc The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 7:e1000292. 2010
    Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias...
  29. ncbi The limits of simulation of the clotting system
    R Wagenvoord
    Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, Netherlands
    J Thromb Haemost 4:1331-8. 2006
    ..To investigate in how far successful simulation of a thrombin generation (TG) curve gives information about the underlying biochemical reaction mechanism...
  30. pmc Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 138:493-502. 2010
    ..The aim of this study was to compare the accuracy of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) in the early diagnosis of HCC.
  31. doi Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation
    Shi Wei Lin
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan, ROC
    J Infect 64:325-34. 2012
    ..Since thrombin plays a very important role in the activation of coagulation, we investigated whether NS1 can bind to thrombin and affect its formation or activity...
  32. ncbi Use of serum PIVKA-II (DCP) determination for differentiation between benign and malignant liver diseases
    R Lamerz
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Anticancer Res 19:2489-93. 1999
    The concentration of Des-gamma-carboxy-prothrombin (DCP) or PIVKA-II has been described to be increased in patients with hepatocellular cancer, along with its elevation in vitamin K deficient states by warfarin or dicoumarol treatment...
  33. doi Fibrin presence within aortic valves in patients with aortic stenosis: association with in vivo thrombin generation and fibrin clot properties
    Joanna Natorska
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland
    Thromb Haemost 105:254-60. 2011
    ..001). Patients with AS had elevated plasma D-dimer (236.4 ± 28 ng/ml, p=0.002) and prothrombin fragment 1+2 (F1.2) (261.7 ± 27.1 pM, p=0.005) compared to AI subjects (142.8 ± 10 ng/ml and 131.2 ± 1...
  34. ncbi Thrombin generation in acute coronary syndrome and stable coronary artery disease: dependence on plasma factor composition
    K Brummel-Ziedins
    Department of Biochemistry, University of Vermont, VT 05446, USA
    J Thromb Haemost 6:104-10. 2008
    ..We investigated whether thrombin generation based on circulating coagulation protein levels, could distinguish between acute and stable coronary artery disease (CAD)...
  35. doi Risk assessment for recurrent venous thrombosis
    Paul Alexander Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Lancet 376:2032-9. 2010
    ..Analysis of preliminary data suggests that risk assessment can also be refined through integration of prothrombotic coagulation changes and clinical risk factors...
  36. ncbi Inhibition of growth and aggregation of calcium oxalate crystals in vitro--a comparison of four human proteins
    P K Grover
    Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia
    Eur J Biochem 253:637-44. 1998
    ..the inhibitory effects of Tamm-Horsfall glycoprotein (THG), human serum albumin (HSA), alpha1-microglobulin and prothrombin fragment 1 (PTF1) on calcium oxalate crystallization...
  37. ncbi Severe venous thromboembolism in a young man with Klinefelter's syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutations
    Mario Lapecorella
    Centro Emostasi e Trombosi, Dipartimento di Clinica Medica, Immunologia e Malattie Infettive MIDIM, University of Bari School of Medicine, Italy
    Blood Coagul Fibrinolysis 14:95-8. 2003
    ..Further examinations also showed a double heterozygosis for G20210A prothrombin and factor V Leiden mutations...
  38. doi Time-dependent analysis of predisposing factors for the recurrence of hepatocellular carcinoma
    Shouta Iwadou
    Department of Internal Medicine, Hiroshima City Hospital, Hiroshima, Japan
    Liver Int 30:1027-32. 2010
    ..The aim of this study is to evaluate the predisposing factors after treatments...
  39. ncbi Prothrombin index decrease: a useful and reliable marker of extensive fibrosis?
    Jean Francois Cadranel
    Unité d Hépatologie, Hopital Laennec, BP 72, 60109 Creil Cedex, France
    Eur J Gastroenterol Hepatol 14:1057-9. 2002
    ..Among those serum markers, we focused on prothrombin index, which seems to be a reliable and non-expansive marker for the diagnosis of extensive fibrosis.
  40. ncbi Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India
    Sanjay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 25:236-9. 2006
    ..The cause of thrombosis in these patients remains unclear. We studied the frequency of mutations in genes for coagulation factors V and II (prothrombin) in 61 Indian patients with PVT and 49 healthy control subjects.
  41. ncbi Prevalence of factor V Leiden, prothrombin and methylene tetrahydrofolate reductase mutations in women with adverse pregnancy outcomes in Lebanon
    Laila F Zahed
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon
    Am J Obstet Gynecol 195:1114-8. 2006
    The purpose of this study was to determine the prevalence of factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase gene mutations in women with adverse pregnancy outcome compared with women who had uneventful pregnancies.
  42. ncbi Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism
    D Coen
    Clinical Institute of Laboratory Diagnostics, Zagreb University Hospital Center, Zagreb, Croatia
    Croat Med J 42:488-92. 2001
    To determine the prevalences of factor V Leiden and the G20210A mutation in the prothrombin gene (PT20210A) and the frequency of their association in healthy subjects and in patients with venous thromboembolism (VTE).
  43. doi High incidence of factor V Leiden and prothrombin G20210A in healthy southern Italians
    Gianluca Sottilotta
    Centro Emofilia, Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
    Clin Appl Thromb Hemost 15:356-9. 2009
    Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism...
  44. ncbi Factor V Leiden G1691A and prothrombin G20210A mutations are common in Tunisia
    C Frere
    J Thromb Haemost 1:2451-2. 2003
  45. ncbi Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in 200 healthy Jordanians
    Suhair S Eid
    Molecular Laboratory, King Hussein Medical Centre, Jordan
    Clin Lab Sci 17:200-2. 2004
    ..In order to estimate the frequency of the factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in the Jordanian population, we screened 200 healthy Jordanian individuals...
  46. ncbi Thrombogenicity of prothrombin complex concentrates
    M Kohler
    Department of Transfusion Medicine, University of Gottingen, Germany
    Thromb Res 95:S13-7. 1999
    Thrombogenicity of factor IX complex or prothrombin complex concentrates (PCC) is a well-acknowledged problem...
  47. doi Prevalence of factor V Leiden and prothrombin G20210A mutation in a large French population selected for nonthrombotic history: geographical and age distribution
    Elisabeth Mazoyer
    Hématologie biologique, Hopital Lariboisiere, Paris, France
    Blood Coagul Fibrinolysis 20:503-10. 2009
    ..Thirty percent of variation in plasma prothrombin level was explained by environmental factors (serum cholesterol, age, oral contraception, hormonal replacement ..
  48. ncbi Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy loss
    Nabil Mtiraoui
    Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
    Eur J Obstet Gynecol Reprod Biol 119:164-70. 2005
    ..We assessed the prevalence of inherited (FV-Leiden and PRT G20210A), and acquired (anti-PL antibodies) risk factors among habitual aborters in Tunisia...
  49. ncbi Absence of factor V Leiden mutation and low prothrombin G 20210 A mutation prevalence in a healthy Moroccan population
    Florence Mathonnet
    Thromb Haemost 88:1073-4. 2002
  50. ncbi Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese
    Hala Tamim
    Thromb Haemost 88:691-2. 2002
  51. doi Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal
    Ingrid Pabinger
    Department of Internal Medicine, Division of Haematology and Haemostaseology, Medical University Vienna, Vienna, Austria
    Ann Hematol 89:309-16. 2010
    b>Prothrombin complex concentrate (PCC) infusion is preferred for emergency reversal of coumarin therapy...
  52. doi Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis
    T Dudding
    Hunter Genetics, Hunter New England Health Service, NSW, Australia
    J Thromb Haemost 6:1869-75. 2008
    ..factor V gene, the 1691G to A change (rs6025) located on chromosome 1q23 (factor V Leiden, FVL), and the other in the prothrombin gene, 20210G to A change (rs1799963) on chromosome 11p11-q12 (PT). These results, however, are conflicting.
  53. ncbi Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    ..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
  54. ncbi Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
    Rainer Friedrich
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Nature 425:535-9. 2003
    ..human pathogen implicated in sepsis and endocarditis, secretes the cofactor staphylocoagulase, which activates prothrombin, without the usual proteolytic cleavages, to directly initiate blood clotting. Here we present the 2...
  55. ncbi Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood
    U Nowak-Gottl
    Department of Paediatrics, Institute of Clinical Chemistry and Laboratory Medicine and Institute of Arteriosclerosis Research, Westphalian Wilhelms University Münster, Germany
    Blood 94:3678-82. 1999
    ..lipoprotein (a) [Lp(a)] levels >30 mg/dL; for the presence of the factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, and the TT677 genotype of methylenetetrahydrofolate reductase (MTHFR); and deficiencies ..
  56. ncbi Exosite-driven substrate specificity and function in coagulation
    S Krishnaswamy
    Joseph Stokes Research Institute, Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Thromb Haemost 3:54-67. 2005
    ..Exosite-driven enzymic function probably represents a widely employed biological strategy for the achievement of high macromolecular substrate specificity...
  57. pmc Prothrombin gene G20210A mutation and obstetric complications
    Robert M Silver
    Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obstet Gynecol 115:14-20. 2010
    To estimate whether maternal carriage of the prothrombin gene G20210A mutation is associated with pregnancy loss, preeclampsia, placental abruption, or small for gestational age (SGA) neonates in a low-risk, prospective cohort.
  58. ncbi Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 96:3329-33. 2000
    Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations...
  59. ncbi Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus
    Maria Laura Bertolaccini
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Thromb Haemost 93:289-97. 2005
    ..Results show that anti-prothrombin antibodies were found in 47% of the patients (aPT in 31% and aPS-PT in 31%)...
  60. ncbi The G20210A prothrombin-gene mutation and the plasminogen activator inhibitor (PAI-1) 5G/5G genotype are associated with early onset of severe preeclampsia
    A Gerhardt
    Department of Obstetrics and Gynecology, Heinrich Heine University Medical Center, Dusseldorf, Germany
    J Thromb Haemost 3:686-91. 2005
    ..9, 95% confidence interval (CI) 0.4, 2.2; prothrombin mutation, OR 1.9, 95% CI 0.5, 7.0; methylentetrahydrofolate reductase 677TT genotype, OR 0.8, 95% CI 0.4, 1...
  61. ncbi Preparation of recombinant alpha-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin
    Hiroshi Yonemura
    Applied Research Department, The Chemo Sero Therapeutic Research Institute Kaketsuken, Kawabe, Kyokushi, Kikuchi, Kumamoto 869 1298
    J Biochem 135:577-82. 2004
    ..Our system is suitable for the large-scale production of recombinant alpha-thrombin, which can be used in place of clinically available alpha-thrombin derived from human or bovine plasma...
  62. pmc Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation
    Rainer Friedrich
    Proteinase Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Biol Chem 281:1188-95. 2006
    Staphylocoagulase (SC) is a protein secreted by the human pathogen, Staphylococcus aureus, that activates human prothrombin (ProT) by inducing a conformational change...
  63. ncbi Venous thromboembolism, oral contraceptives and high prothrombin levels
    C Legnani
    Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, Dipartimento Cardiovascolare, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    J Thromb Haemost 1:112-7. 2003
    The G20210A prothrombin mutation, associated with elevated prothrombin levels, is a risk factor for venous thromboembolism (VTE) and displays a strong interaction with oral contraceptives (OC)...
  64. ncbi Distinct association of factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisia and Lebanon
    Lobna Bouaziz-Borgi
    Faculty of Pharmacy, University of Monastir, Tunisia
    Am J Hematol 81:641-3. 2006
    Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) were associated with venous thrombosis among Caucasians...
  65. ncbi Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale
    Vesa Karttunen
    Department of Neurology, Oulu University Central Hospital, Box 25, FIN 90029 Oulu, Finland
    Blood Coagul Fibrinolysis 14:261-8. 2003
    ..We assessed the occurrence of several prothrombotic states (factor V Leiden, prothrombin G20210A, deficiencies in protein S, protein C and antithrombin, lupus anticoagulant, anticardiolipin antibodies,..
  66. doi Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate
    Ingrid Pabinger-Fasching
    Haematology and Haemostaseology Division, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Res 122:S19-22. 2008
    Bleeding can be a major problem in patients on oral anticoagulation therapy. Beriplex P/N is a prothrombin complex concentrate (PCC) that has been developed for the rapid reversal of anticoagulation in patients requiring immediate ..
  67. doi Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review
    Jodi B Segal
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 301:2472-85. 2009
    ..Testing for genetic risks for venous thromboembolism (VTE) is common, but the safety and utility of such testing need review...
  68. doi MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis
    Mario D'Amico
    Department of Gastroenterology, University of Palermo, Palermo, Italy
    J Thromb Thrombolysis 28:70-3. 2009
    We studied thrombophilic genetic factors (TGFs) MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, prothrombin G20210A as risk factors in 94 patients with HCC with and without portal vein thrombosis (PVT), compared with 214 patients with liver ..
  69. ncbi Acquired activated protein C resistance associated with IgG antibodies against beta2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism
    Junzo Nojima
    Laboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan
    Clin Chem 51:545-52. 2005
    ..Our aim was to clarify the roles of anti-phospholipid (aPL) antibodies in the pathogenesis of venous thromboembolism (VTE) in patients with systemic lupus erythematosus (SLE)...
  70. doi Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients
    Nanyawan Rungroj
    Division of Medical Molecular Biology, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Urology 77:249.e17-23. 2011
    ..To evaluate genetic variations associated with kidney stone disease in Northeastern Thai patients...
  71. doi Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy
    Kentaroh Yamamoto
    Department of Surgery, Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Division, University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 16:2795-804. 2009
    Alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) are well-known tumor markers of hepatocellular carcinoma (HCC)...
  72. ncbi Prothrombin binds to the surface of apoptotic, but not viable, cells and serves as a target of lupus anticoagulant autoantibodies
    Paolo D'Agnillo
    Division of Rheumatology, Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec, Canada
    J Immunol 170:3408-22. 2003
    ..Most LA Ab are specific for either beta(2)-glycoprotein I (beta(2)GPI) or prothrombin (PT), two PL-binding proteins...
  73. ncbi Heterozygous prothrombin G20210A gene mutation in a patient with livedoid vasculitis
    Jason Gotlib
    Arch Dermatol 139:1081-3. 2003
  74. ncbi Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
    J M Soria
    Unitat d Hemostàsia i Trombosi Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood 95:2780-5. 2000
    Association studies suggest that the G20210A mutation (G to A substitution at nucleotide position 20210) in the prothrombin gene (PT) is associated with increased plasma prothrombin activity and with increased risk for venous ..
  75. ncbi G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism
    J S Miles
    Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 37:215-8. 2001
    The study was done to determine whether the G20210A mutation in the prothrombin gene increases the risk of recurrent venous thromboembolism (VTE), both alone and in combination with factor V Leiden.
  76. ncbi Nucleotide sequence of the gene for human prothrombin
    S J Degen
    Children s Hospital Research Foundation, Cincinnati, Ohio
    Biochemistry 26:6165-77. 1987
    A human genomic DNA library was screened for the gene coding for human prothrombin with a cDNA coding for the human protein. Eighty-one positive lambda phage were identified, and three were chosen for further characterization...
  77. doi Vascular behcet and mutations in thrombogenic genes: methylene tetrahydrofolate reductase, factor V, and prothrombin
    Efrat Dagan
    Department of Nursing, University of Haifa, Haifa, Israel
    Genet Test Mol Biomarkers 16:30-5. 2012
    ..inherited gene defects, factor V (FV) 1691A (Leiden), methylene tetrahydrofolate reductase (MTHFR) 677T, and prothrombin 20210A, are known risk factors for thrombosis...
  78. ncbi Abnormal melt curve profile during prothrombin 20210G --> A analysis due to the 20209C --> T variant
    S Terence Dunn
    Molecular Pathology Laboratory, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Blood Coagul Fibrinolysis 17:599-602. 2006
    ....
  79. doi Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma
    Myoung Ha Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 27:313-22. 2012
    The clinical utility of alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) as a predictor of treatment outcome in patients with advanced hepatocellular carcinoma (HCC) receiving hepatic artery infusional chemotherapy (HAIC) or ..
  80. ncbi Update on the mechanism of action and future of activated prothrombin complex concentrates
    Peter L Turecek
    Baxter BioScience, Industriestrasse 67, A 1220 Vienna, Austria
    Curr Hematol Rep 3:331-7. 2004
    Activated prothrombin complex concentrates (aPCCs) are an established treatment for bleeding in patients with inhibitors...
  81. doi Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    Anne Godier
    Department of Anaesthesia and Critical Care, Paris Descartes University, Hotel Dieu University Hospital, Paris, France
    Anesthesiology 116:94-102. 2012
    ..Objectives were to study efficacy and safety of recombinant activated factor VII (rFVIIa) and prothrombin complex concentrate (PCC) to reverse the anticoagulant effect of an overdose of rivaroxaban in a rabbit model ..
  82. doi The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease
    P M Mannucci
    Centro Emofilia e Trombosi A Bianchi Bonomi, Scientific Direction, IRCCS Fondazione Cà Granda Ospedale Maggiore, Universita degli Studi di Milano, Milan, Italy
    J Thromb Haemost 8:2116-21. 2010
    ....
  83. ncbi Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara
    Yotis A Senis
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, Wolfson Drive, Edgbaston, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1764:863-71. 2006
    In this study, we isolated a novel prothrombin activator from the venom of Bothrops cotiara, a Brazilian lance-headed pit viper (Cotiara, Jararaca preta, Biocotiara), which we have designated "cotiaractivase" (prefix: cotiar- from B...
  84. ncbi The G20210A prothrombin polymorphism is not associated with increased thromboembolic risk in a large protein C deficient kindred
    E G Bovill
    Department of Pathology, University of Vermont, Burlington 05405, USA
    Thromb Haemost 83:366-70. 2000
    Likelihood analysis was used to test the effect of the G20210A prothrombin mutation and the His107Pro protein C mutation (resulting from a C insertion) on thrombosis status and prothrombin level in a large kindred of French Canadian ..
  85. doi Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment
    S L Meeks
    Aflac Cancer Center and Blood Disorders Service, Children s Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA
    Haemophilia 14:1159-63. 2008
    b>Prothrombin (factor II) deficiency is a rare autosomal recessive coagulation disorder that occurs in approximately 1 in 1-2 million people...
  86. ncbi A prospective study of antibodies to beta2-glycoprotein I and prothrombin, and risk of thrombosis
    R Forastiero
    Division of Hematology, Thrombosis and Hemostasis, Institute of Cardiology and Cardiovascular Surgery, Favaloro Foundation, Favaloro University, Buenos Aires, Argentina
    J Thromb Haemost 3:1231-8. 2005
    ..We assessed the contribution of antibodies to beta2-glycoprotein I (anti-beta2GPI) and prothrombin (anti-PT) to the thrombotic risk in a cohort of 194 consecutive patients with persistent LA and/or aCL...
  87. pmc Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation
    Nitsan Maharshak
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel
    World J Gastroenterol 17:5007-13. 2011
    ..To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutations suffer from increased rates of liver fibrosis...
  88. ncbi Factor V Leiden, prothrombin G20210A, and protein C mutation frequency in Turkish venous thrombosis patients
    Julide Altinisik
    Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Clin Appl Thromb Hemost 14:415-20. 2008
    ..of venous thrombosis, including mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene...
  89. doi Prothrombin G20210A and factor V Leiden polymorphisms in stroke
    Thierry Paluku They-They
    Laboratory of Genetic and Molecular Pathology, Medical School, Hassan II University, 19, rue Tarik Ibn Ziad, BP 9154, 10000, Casablanca, Morocco
    J Mol Neurosci 46:210-6. 2012
    ..matched 1:2 for their age, gender, and ethnic background to 182 healthy controls who were genotyped for the prothrombin G20210A mutation and factor V (FV) Leiden and were assessed for conventional risk factors for stroke...
  90. ncbi Combined factor V Leiden and prothrombin genotyping in patients presenting with thromboembolic episodes
    J A Friedline
    Kennewick, Wash, USA
    Arch Pathol Lab Med 125:105-11. 2001
    Several genetic defects are associated with increased risk of venous thrombosis. The factor V Leiden (FVL) and prothrombin G20210A mutations are the most frequent causes of inherited thrombophilia.
  91. ncbi No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study
    Adam M Smiles
    Department of Pathology, College of Medicine, University of Vermont, Burlington, USA
    Thromb Haemost 87:614-21. 2002
    b>Prothrombin is a key factor in blood clotting, a process intimately involved in thrombotic disease. We assessed prothrombin levels and G20210A genotype in a case-control study within the Cardiovascular Health Study...
  92. doi Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells
    Fu Jun Gao
    Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, 250012, China
    Life Sci 83:815-20. 2008
    Des-gamma-carboxyl prothrombin (DCP) is a serum protein produced by hepatocellular carcinoma (HCC) cells. The aim of this study was to evaluate the angiogenic activity of DCP in HCC cells.
  93. ncbi Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1+2 in patients with type 2 diabetes
    Kwang Kon Koh
    Cardiology, Laboratory Medicine, Gachon Medical School, Incheon, Republic of Korea
    Atherosclerosis 194:230-7. 2007
    ..64 to 0.43 nM, P<0.001). All three therapies significantly reduced prothrombin fragment 1+2 (F1+2) levels from their respective baselines (P=0.037, P<0.001, and P=0.057, respectively)...
  94. ncbi Heterozygous prothrombin 20210G/A mutation, associated with hyperhomocysteinemia, and homozygous methylenetetrahydrofolate reductase 677C/T mutation, in a patient with portal and mesenteric venous thrombosis
    Ihab I Elhajj
    Department of Internal Medicine, American University of Beirut Medical Center AUBMC, Beirut, Lebanon
    Hematol J 5:540-2. 2004
    ....
  95. doi Des-γ-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway
    Pan Yue
    Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, China
    Eur J Cancer 47:1115-24. 2011
    Des-γ-carboxy prothrombin (DCP), an aberrant prothrombin produced by hepatocellular carcinoma (HCC) cells, has been shown to be associated with the biological malignant potential of HCC...
  96. ncbi Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke
    Justo Aznar
    La Fe University Hospital, Department of Clinical Pathology, Avd Campanar 21, 46009 Valencia, Spain
    Thromb Haemost 91:1031-4. 2004
    The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke. Prevalence of FVL (4.1%) and PT 20210 (8...
  97. ncbi The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin
    Ken Shirabe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 95:235-40. 2007
    ..The size and histological grade of the tumor were significantly correlated with the mvi. The des-gamma-carboxy prothrombin (DCP) is a mvi predictor...
  98. ncbi Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study
    Ivan Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arch Intern Med 164:1932-7. 2004
    The prothrombin 20210A mutation has been associated with an increased risk of venous thromboembolism (VTE). Its relationship with arterial disease and pregnancy-related complications is, however, still uncertain...
  99. ncbi Factor V Leiden and prothrombin gene 20210A variant in neonatal thromboembolism and in healthy neonates and adults: a study in a single center
    Begum Atasay
    Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
    Pediatr Hematol Oncol 20:627-34. 2003
    ..Investigations included screening for factor V 1691A and prothrombin 20210A. Seven of 9 neonates had one or more risk factors at the time of thromboembolism...
  100. ncbi Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee
    Anders Bjorkman
    Department of Orthopaedics, University Hospital Malmo, 20502, Malmo, Sweden
    Arch Orthop Trauma Surg 125:51-5. 2005
    ..The purpose of this study was to examine the association between osteonecrosis of the knee and abnormalities in the thrombotic pathway in the form of factor V Leiden and the prothrombin 20210A gene mutation.
  101. ncbi Prothrombin fragment 1+2 in urine as an indicator of sustained coagulation activation after total hip arthroplasty
    Lars C Borris
    Department of Orthopaedics, Section of Traumatology, Arhus University Hospital, Arhus
    Thromb Res 121:369-76. 2007
    b>Prothrombin fragment 1+2 measured in spot urine (uF1+2) is an indicator of thrombin generation...

Research Grants79

  1. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2010
    ..1) Sulfated DHPs (CDs, FDs and SDs) prolong prothrombin time at concentrations 2-6-fold below that of the clinically used LMWH enoxaparin, while in the activated ..
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    Umesh Desai; Fiscal Year: 2009
    ..1) Sulfated DHPs (CDs, FDs and SDs) prolong prothrombin time at concentrations 2-6-fold below that of the clinically used LMWH enoxaparin, while in the activated ..
  3. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2006
    ..Mice expressing A20 maintain normal liver function as assessed by prothrombin time while controls suffer from a severe bleeding diathesis...
  4. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2003
    ..Mice expressing A20 maintain normal liver function as assessed by prothrombin time while controls suffer from a severe bleeding diathesis...
  5. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2010
    Thrombin, the central regulatory molecule of blood coagulation, is produced by prothrombin (II) proteolysis by a platelet-membrane-bound enzyme (factor Xa) and its associated cofactor (factor Va)...
  6. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2010
    ..In Aim 1, we address the hypotheses that fXI is activated by -thrombin in plasma, and that other products of prothrombin activation, such as meizothrombin and -thrombin, activate fXI...
  7. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2009
    ..In Aim 1, we address the hypotheses that fXI is activated by -thrombin in plasma, and that other products of prothrombin activation, such as meizothrombin and -thrombin, activate fXI...
  8. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
    ..This application explores the phospholipid binding specificity of prothrombin and the nature of the prothrombin-membrane binding site...
  9. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
    b>Prothrombin is the precursor of thrombin, the central enzyme in blood coagulation...
  10. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2010
    Thrombin, the central regulatory molecule of blood coagulation, is produced by prothrombin (II) proteolysis by a platelet-membrane-bound enzyme (factor Xa) and its associated cofactor (factor Va)...
  11. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul Bock; Fiscal Year: 2007
    ..mechanisms of the procoagulant activation of human factor V, factor Va cofactor activity in regulating prothrombin (ProT) activation, and the mechanism of the anticoagulant inactivation of factor Va by activated protein C (ARC)..
  12. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    ..mechanisms of the procoagulant activation of human factor V, factor Va cofactor activity in regulating prothrombin (ProT) activation, and the mechanism of the anticoagulant inactivation of factor Va by activated protein C (ARC)..
  13. FACTOR XI PHYSIOLOGY AND MOLECULAR BIOLOGY
    David Gailani; Fiscal Year: 2004
    ..In contrast to the vitamin K-dependent proteins (prothrombin and factors VII, IX, and X), factor XI lacks a calcium binding Gla domain...
  14. Structure/Function Study of the Anticoagulant Protein S
    Alan Rigby; Fiscal Year: 2005
    ..The penultimate step in blood coagulation is the conversion of prothrombin to thrombin, which is then responsible for the conversion of fibrinogen to fibrin...
  15. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 1993
    ..In order to understand the mechanisms by which the activation of prothrombin is regulated we have undertaken an investigation of the structure and function of the factor V molecule...
  16. Mechanisms linking the hemostatic protease thrombin to arthritic disease
    Matthew J Flick; Fiscal Year: 2010
    ..Activation of the hemostatic system and the subsequent conversion of prothrombin to the active serine protease thrombin is a prominent feature of RA...
  17. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ..between hormone replacement therapy and the prothrombotic mutations, Factor V Leiden and the recently described prothrombin mutation (20210A) on the incidence of VTE in a population-based case-control study conducted at Group Health ..
  18. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2007
    ..Both chains of the cofactor interact with factor Xa while only the heavy chain of the cofactor binds prothrombin. The factor Va cofactor activity is efficiently down-regulated following proteolysis of the heavy chain by ..
  19. Biomakers in Sickle Cell Anemia: Response to Hydroxyurea
    Marie Stuart; Fiscal Year: 2004
    ..Markers of coagulation activation will include whole blood tissue factor activity (WBTF) and prothrombin fragment F1.2 levels...
  20. PROTEINS OF COAGULATION PATHWAYS
    John Griffin; Fiscal Year: 1999
    ..to C4BP; and iii) similarly, residues on the surface of factor Va are essential for its binding to protein S, prothrombin and factor Xa...
  21. EPIDEMIOLOGY OF HEMOSTASIS IN PERSONS OVER 65
    Russell Tracy; Fiscal Year: 1993
    ..and fibrinolysis in individuals 65 years and older: measures of pro-coagulation (factor antigen VII, prothrombin fragment 1...