plasminogen

Summary

Summary: Precursor of fibrinolysin (plasmin). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.

Top Publications

  1. ncbi Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites
    Kyle D Phipps
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Cancer Res 71:6676-83. 2011
  2. pmc The enolase of Borrelia burgdorferi is a plasminogen receptor released in outer membrane vesicles
    A Toledo
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA
    Infect Immun 80:359-68. 2012
  3. pmc Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:3469-74. 2012
  4. pmc OspC is potent plasminogen receptor on surface of Borrelia burgdorferi
    Ozlem Onder
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:16860-8. 2012
  5. ncbi Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action
    Meena R Sharma
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:136-45. 2006
  6. ncbi Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis
    W R Ji
    Department of Oncology Drug Discovery, Bristol Myers Squibb Pharmaceuticals, Inc, Princeton, New Jersey 08543, USA
    FASEB J 12:1731-8. 1998
  7. pmc Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT
    Shahrzad Lighvani
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 118:5622-30. 2011
  8. ncbi Structure and function of the plasminogen/plasmin system
    Francis J Castellino
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 93:647-54. 2005
  9. ncbi The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy
    Nicolai Sidenius
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Cancer Metastasis Rev 22:205-22. 2003
  10. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009

Detail Information

Publications343 found, 100 shown here

  1. ncbi Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites
    Kyle D Phipps
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Cancer Res 71:6676-83. 2011
    ..In this study, we offer genetic evidence that plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site...
  2. pmc The enolase of Borrelia burgdorferi is a plasminogen receptor released in outer membrane vesicles
    A Toledo
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA
    Infect Immun 80:359-68. 2012
    ..In borreliae, as well as in other bacteria, a number of membrane proteins have been implicated in binding plasminogen. The activation and transformation of plasminogen into its proteolytically active form, plasmin, enhances the ..
  3. pmc Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:3469-74. 2012
    ..These data suggest that the class of compounds represented by CCG-2979 may be of therapeutic value for the treatment of GAS and potentially other gram-positive infections in humans...
  4. pmc OspC is potent plasminogen receptor on surface of Borrelia burgdorferi
    Ozlem Onder
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:16860-8. 2012
    ..burgdorferi can accomplish these tasks without an endogenous extra-cytoplasmic protease by commandeering plasminogen, the highly abundant precursor of the vertebrate protease plasmin. However, the molecular mechanism by which B...
  5. ncbi Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action
    Meena R Sharma
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:136-45. 2006
    Angiostatin, the N-terminal four kringles (K1-4) of parent molecule plasminogen, is reported to block Lewis Lung Carcinoma (LLC) tumor growth and metastasis. However, angiostatin's mechanism of action is unclear...
  6. ncbi Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis
    W R Ji
    Department of Oncology Drug Discovery, Bristol Myers Squibb Pharmaceuticals, Inc, Princeton, New Jersey 08543, USA
    FASEB J 12:1731-8. 1998
    ..Our data suggest that different kringle domains may contribute to the overall anti-angiogenic function of angiostatin by their distinct anti-migratory activities...
  7. pmc Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT
    Shahrzad Lighvani
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 118:5622-30. 2011
    ..These functions are promoted by plasminogen receptors exposing C-terminal basic residues on the macrophage surface...
  8. ncbi Structure and function of the plasminogen/plasmin system
    Francis J Castellino
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 93:647-54. 2005
    Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators urokinase-type Pg activator (uPA) or tissue-type ..
  9. ncbi The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy
    Nicolai Sidenius
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Cancer Metastasis Rev 22:205-22. 2003
    ..A major protease system responsible for ECM degradation is the plasminogen activation system, which generates the potent serine protease plasmin...
  10. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..The glycolytic enzyme enolase-1 (ENO-1) binds plasminogen at the cell surface, enhancing local plasmin production...
  11. ncbi Plasminogen receptors: the sine qua non of cell surface plasminogen activation
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 10:1754-62. 2005
    Localization of plasminogen and plasminogen activators on cell surfaces promotes plasminogen activation and serves to arm cells with the broad spectrum proteolytic activity of plasmin...
  12. ncbi S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors
    Mijung Kwon
    Department of Biochemistry, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Front Biosci 10:300-25. 2005
    ..The assembly of plasminogen and tissue plasminogen activator at the endothelial cell surface or on the fibrin clot provides a focal point ..
  13. ncbi Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice
    V A Ploplis
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Blood 91:2005-9. 1998
    It is widely held that the plasminogen (Plg) system plays a role in inflammation through plasmin-mediated directional cell migration...
  14. ncbi Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2
    Erica A Peterson
    Canadian Blood Services, R and D Department, 1800 Alta Vista Drive, Ottawa, ON K1G 4J5, Canada
    J Cell Sci 116:2399-408. 2003
    ..2 (A2) and its ligand p11 have been implicated in fibrinolysis because of their ability to accelerate tissue plasminogen activator (tPA)-mediated activation of plasminogen to plasmin...
  15. pmc Characterization of novel OmpA-like protein of Leptospira interrogans that binds extracellular matrix molecules and plasminogen
    Rosane Oliveira
    Centro de Biotecnologia, Instituto Butantan, Sao Paulo, Brazil
    PLoS ONE 6:e21962. 2011
    ..Recently, we have identified LIC12238 as a plasminogen (PLG)-binding receptor...
  16. pmc Histone H2B as a functionally important plasminogen receptor on macrophages
    Riku Das
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH, USA
    Blood 110:3763-72. 2007
    b>Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are not well defined...
  17. pmc Plasminogen- and fibronectin-binding protein B is involved in the adherence of Streptococcus pneumoniae to human epithelial cells
    Salvatore Papasergi
    Elie Metchnikoff Department, Universita di Messina, Messina I 98125, Italy
    J Biol Chem 285:7517-24. 2010
    ..This locus encodes for an approximately 120-kDa protein, herein referred to as plasminogen- and fibronectin-binding protein B (PfbB), which displays an LPXTG cell wall anchoring motif and six repetitive ..
  18. ncbi S100A10 regulates plasminogen-dependent macrophage invasion
    Paul A O'Connell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Blood 116:1136-46. 2010
    The plasminogen activation system plays an integral role in the migration of macrophages in response to an inflammatory stimulus, and the binding of plasminogen to its cell-surface receptor initiates this process...
  19. pmc Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation
    Jessica McCready
    Department of Physiology, Tufts University, 136 Harrison Ave, Boston, MA 02111, USA
    BMC Cancer 10:294. 2010
    ..Current treatments are not effective in targeting metastasis. The molecular chaperone hsp90alpha is secreted from invasive cancer cells and activates MMP-2 to enhance invasiveness, required for the first step in metastasis...
  20. pmc Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
    Nicholas M Andronicos
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 115:1319-30. 2010
    Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad spectrum proteolytic activity of plasmin...
  21. ncbi Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
    Hongmin Sun
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Science 305:1283-6. 2004
    ..a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other ..
  22. ncbi cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
    J W McLean
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080
    Nature 330:132-7. 1987
    ..Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is ..
  23. pmc Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Clin Invest 118:3012-24. 2008
    ..b>Plasminogen (Plg) is a protease that binds to the ECM and, upon conversion to plasmin, degrades multiple ECM proteins...
  24. ncbi α-Enolase: a promising therapeutic and diagnostic tumor target
    Michela Capello
    Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    FEBS J 278:1064-74. 2011
    enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation...
  25. pmc Tissue plasminogen activator is a potent activator of PDGF-CC
    Linda Fredriksson
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
    EMBO J 23:3793-802. 2004
    Tissue plasminogen activator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin...
  26. pmc Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination
    Sarbani Bhattacharya
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Biomed Biotechnol 2012:482096. 2012
    ..A large number of pathogens express plasminogen receptors which immobilize plasmin(ogen) on the bacterial surface...
  27. ncbi Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78
    Don J Davidson
    Department of Cancer Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Cancer Res 65:4663-72. 2005
    Kringle 5 (K5) of human plasminogen has been shown to inhibit angiogenesis by inducing the apoptosis of proliferating endothelial cells...
  28. pmc A processed multidomain mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia
    Lisa M Seymour
    Schools of Biological Sciences, University of Wollongong, New South Wales 2522, Australia
    J Biol Chem 285:33971-8. 2010
    ..M. hyopneumoniae cells were found to also bind plasminogen in a dose-dependent and saturable manner; the C-terminal domain of P116 binds to plasminogen (K(D) 44 ± 5 nm)...
  29. pmc OmpL1 is an extracellular matrix- and plasminogen-interacting protein of Leptospira spp
    Luis G V Fernandes
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, Sao Paulo, Brazil
    Infect Immun 80:3679-92. 2012
    ..We describe that OmpL1 is a novel leptospiral extracellular matrix (ECM)-binding protein and a plasminogen (PLG) receptor...
  30. ncbi Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II
    D J Falcone
    Departments of Pathology, Cell Biology, Pediatrics, and Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, NY, USA
    Blood 97:777-84. 2001
    Genetic evidence demonstrates the importance of plasminogen activation in the migration of macrophages to sites of injury and inflammation, their removal of necrotic debris, and their clearance of fibrin...
  31. ncbi Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Mol Immunol 47:541-50. 2009
    ..Recombinant Pra1 binds Factor H, FHL-1 and also plasminogen. Attached to Pra1, the three human proteins are functionally active...
  32. pmc L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages
    Riku Das
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NB50, Cleveland, OH 44195, USA
    Circ Res 105:167-75. 2009
    ..b>Plasminogen (Plg) is an important mediator of macrophage recruitment, and this role depends on its interaction with Plg ..
  33. pmc Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection
    Fiona C McKay
    Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Infect Immun 72:364-70. 2004
    ..Expression of a plasminogen-binding GAS M-like protein (PAM) has been associated with skin infection in isolates elsewhere (D. Bessen, C. M...
  34. ncbi Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells
    Tri Minh Bui Nguyen
    Department of Pharmacology, University of Minnesota Medical School, 321 Church Street SE, Minnesota, MN 55455, USA
    Blood 109:4793-802. 2007
    ..Kringle 5 (K5) of human plasminogen is a potent angiogenesis inhibitor...
  35. pmc Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus
    Robert Pawlak
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Proc Natl Acad Sci U S A 102:18201-6. 2005
    ..Strikingly, the stress-induced decrease in NMDA receptors coincides spatially with sites of plasminogen activation, thereby predicting a role for tissue plasminogen activator (tPA) in this form of stress-induced ..
  36. ncbi Fibrin and fibrinolysis in infection and host defense
    J L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Thromb Haemost 5:24-31. 2007
    ..Recent studies of mice with selected alterations in host plasminogen and other hemostatic factors have begun to reveal a seminal role of bacterial plasminogen activators and fibrin ..
  37. pmc Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    Manuel Yepes
    Department of Vascular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Clin Invest 112:1533-40. 2003
    ..In this study we demonstrate that an increase in endogenous tissue-type plasminogen activator (tPA) activity in the perivascular tissue following cerebral ischemia induces opening of the BBB via ..
  38. ncbi Identification of histone H2B as a regulated plasminogen receptor
    Thomas Herren
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NB50, Cleveland, Ohio 44195, USA
    Biochemistry 45:9463-74. 2006
    Tethering of plasminogen to cell surfaces controls plasmin formation and, thereby, influences pericellular proteolysis and cell migration...
  39. pmc The interaction of Streptococcus pneumoniae with plasmin mediates transmigration across endothelial and epithelial monolayers by intercellular junction cleavage
    Cécile Attali
    Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, Laboratoire d Ingénierie des Macromolécules, 41 rue Jules Horowitz, 38027 Grenoble, France
    Infect Immun 76:5350-6. 2008
    ..The plasminogen system is highly important for the tissue barrier degradation which allows cell migration...
  40. ncbi Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo
    F Lluis
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 97:1703-11. 2001
    b>Plasminogen activators urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are extracellular proteases involved in various tissue remodeling processes...
  41. ncbi An active site water network in the plasminogen activator pla from Yersinia pestis
    Elif Eren
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Structure 18:809-18. 2010
    The plasminogen activator Pla from Yersinia pestis is an outer membrane protease (omptin) that is important for the virulence of plague. Here, we present the high-resolution crystal structure of wild-type, enzymatically active Pla at 1...
  42. ncbi Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica
    Maini Kukkonen
    Division of General Microbiology, Department of Biosciences, FIN 00014 University of Helsinki, Helsinki, Finland
    Mol Microbiol 51:215-25. 2004
    ..pestis and Salmonella enterica express beta-barrel surface proteases of the omptin family that activate human plasminogen. Plasminogen activation is central in pathogenesis of plague but has not, however, been found to be important ..
  43. pmc Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus
    H Goto
    Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
    J Virol 75:9297-301. 2001
    When expressed in vitro, the neuraminidase (NA) of A/WSN/33 (WSN) virus binds and sequesters plasminogen on the cell surface, leading to enhanced cleavage of the viral hemagglutinin...
  44. pmc The plasminogen fibrinolytic pathway is required for hematopoietic regeneration
    Beate Heissig
    Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Cell Stem Cell 1:658-70. 2007
    ..However, little is known about how this stress response is coordinated. Here, we show that plasminogen (Plg), a classical fibrinolytic factor, is a key player in controlling this stress response...
  45. pmc Paracoccidioides brasiliensis enolase is a surface protein that binds plasminogen and mediates interaction of yeast forms with host cells
    Sarah Veloso Nogueira
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, ICBII, Campus II, Universidade Federal de Goias, 74001 970, Goiania, Goias, Brazil
    Infect Immun 78:4040-50. 2010
    ..brasiliensis. Interaction of surface-bound enolase with plasminogen has been incriminated in tissue invasion for pathogenesis in several pathogens...
  46. ncbi Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..Active plasmin is generated from proteolytic cleavage of the zymogen plasminogen (Plg) by urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
  47. ncbi The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation
    Ziyong Sun
    Institute of Molecular Medicine, Nanjing University, 210093, Nanjing, PR China
    Biochim Biophys Acta 1596:182-92. 2002
    Prourokinase-induced plasminogen activation is complex and involves three distinct reactions: (1) plasminogen activation by the intrinsic activity of prourokinase; (2) prourokinase activation by plasmin; (3) plasminogen activation by ..
  48. ncbi Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae
    Simone Bergmann
    Department of Microbial Pathogenicity, GBF German Research Centre for Biotechnology, 38124 Braunschweig, Germany
    Mol Microbiol 49:411-23. 2003
    ..b>Plasminogen binds to surface displayed pneumococcal alpha-enolase (Eno) and is subsequently activated to the serine ..
  49. ncbi Stimulation of vascular smooth muscle cell proliferation and migration by apolipoprotein(a) is dependent on inhibition of transforming growth factor-beta activation and on the presence of kringle IV type 9
    Caroline H O'Neil
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:55187-95. 2004
    ..which in turn is caused by the ability of apo(a) to decrease the formation of plasmin from its precursor plasminogen. We utilized a battery of recombinant apo(a) variants that represent systematic deletions of the various ..
  50. ncbi Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation
    Alexandre Semov
    Supratek Pharma Inc, Montreal, Quebec H9S 1A9, Canada
    J Biol Chem 280:20833-41. 2005
    ..Here we report that extracellular S100A4 interacts with annexin II, an endothelial plasminogen co-receptor...
  51. ncbi Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer
    Amit Michaeli
    Hematology Unit, Hadassah Hebrew University Medical Center, Mount Scopus, 91240 Jerusalem, Israel
    Biochem Biophys Res Commun 368:368-73. 2008
    ..In the present study, we demonstrate that SAA enhances the plasminogen activation (PA)-activity of HT-29 colon cancer cell line...
  52. ncbi Plasminogen Kringle 5 blocks tumor progression by antiangiogenic and proinflammatory pathways
    Sabrina R Perri
    Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Cancer Ther 6:441-9. 2007
    Proteolytic processing of human plasminogen generates potent antiangiogenic peptides such as angiostatin...
  53. pmc A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation
    S Selvarajan
    Department of Anatomy, Box 0452, University of California, 513 Parnasssus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 3:267-75. 2001
    Here we show that plasma kallikrein (PKal) mediates a plasminogen (Plg) cascade in adipocyte differentiation...
  54. ncbi Analysis of the invasion-metastasis mechanism in pancreatic cancer: involvement of plasmin(ogen) cascade proteins in the invasion of pancreatic cancer cells
    Xiaodong Tan
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Int J Oncol 28:369-74. 2006
    ..The strong expression of plasmin(ogen), urokinase type plasminogen activator (uPA) and uPA receptor (uPAR), and apparently weak expression of the relevant proteins were found in ..
  55. ncbi Increased bone formation in mice lacking plasminogen activators
    E Daci
    Laboratorium of Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, Belgium
    J Bone Miner Res 18:1167-76. 2003
    b>Plasminogen activators tPA and uPA are involved in tissue remodeling, but their role in bone growth is undefined. Mice lacking tPA and uPA show increased bone formation and bone mass...
  56. pmc Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein
    Angela M Floden
    Department of Microbiology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, United States of America
    PLoS ONE 6:e27502. 2011
    ..In order to aid in its dissemination, B. burgdorferi binds plasminogen, a component of the hosts' fibrinolytic system. Plasminogen bound to the surface of B...
  57. ncbi M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate
    M L Sanderson-Smith
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    FASEB J 22:2715-22. 2008
    ..Mutagenesis of the NS88.2 plasminogen binding M protein Prp was undertaken to examine the contribution of plasminogen binding and cell surface ..
  58. ncbi Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis
    Miriam Esgleas
    Groupe de Recherche sur les Maladies Infectieuses du Porc GREMIP and Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
    Microbiology 154:2668-79. 2008
    ..ELISA demonstrated that SsEno binds specifically to fibronectin and plasminogen in a lysine-dependent manner...
  59. pmc Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD
    L Claesson-Welsh
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Box 575, S 751 23 Uppsala, Sweden
    Proc Natl Acad Sci U S A 95:5579-83. 1998
    Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization...
  60. ncbi Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation
    Yung Chun Chuang
    Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan 701
    J Immunol 187:6483-90. 2011
    ..However, the mechanisms that cause pathology in DHF/DSS patients are still unclear. Because conversion of plasminogen (Plg) to plasmin (Plm) is the first step in the activation of fibrinolysis, Abs against Plg found in DHF/DSS ..
  61. pmc Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis
    Fatma Berri
    VirPatH, EA4610 Virologie et Pathologie Humaine, Faculté de médecine RTH Laennec, Universite Claude Bernard Lyon 1, Lyon, France
    PLoS Pathog 9:e1003229. 2013
    ..Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and ..
  62. ncbi SCM, a novel M-like protein from Streptococcus canis, binds (mini)-plasminogen with high affinity and facilitates bacterial transmigration
    Marcus Fulde
    Department of Medical Microbiology, Helmholtz Centre for Infection Research HZI, Braunschweig, Germany
    Biochem J 434:523-35. 2011
    ..In the present paper we report the binding of human plasminogen to S. canis and the recruitment of proteolytically active plasmin on its surface...
  63. pmc Plasminogen is a complement inhibitor
    Diana Barthel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Biol Chem 287:18831-42. 2012
    b>Plasminogen is a 92-kDa single chain glycoprotein that circulates in plasma as a zymogen and when converted to proteolytically active plasmin dissolves preformed fibrin clots and extracellular matrix components...
  64. pmc Features of two proteins of Leptospira interrogans with potential role in host-pathogen interactions
    Renan F Domingos
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    BMC Microbiol 12:50. 2012
    ..Leptospires were shown to express surface proteins that interact with the extracellular matrix (ECM) and to plasminogen (PLG)...
  65. ncbi Lsa30, a novel adhesin of Leptospira interrogans binds human plasminogen and the complement regulator C4bp
    Natalie M Souza
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Microb Pathog 53:125-34. 2012
    ..Moreover, the Lsa30 is a plasminogen (PLG) receptor, capable of generating plasmin, in the presence of activator...
  66. ncbi Enolase of Streptococcus pneumoniae binds human complement inhibitor C4b-binding protein and contributes to complement evasion
    Vaibhav Agarwal
    Medical Protein Chemistry, Department of Laboratory Medicine, Lund University, S 205 02 Malmo, Sweden
    J Immunol 189:3575-84. 2012
    ..In this study, we identified the pneumococcal glycolytic enzyme enolase, a nonclassical cell surface and plasminogen-binding protein, as an additional pneumococcal C4BP-binding protein...
  67. pmc A surface enolase participates in Borrelia burgdorferi-plasminogen interaction and contributes to pathogen survival within feeding ticks
    Sarah Veloso Nogueira
    Department of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    Infect Immun 80:82-90. 2012
    ..However, the protein also interacts with host plasminogen, potentially leading to its activation and resulting in B. burgdorferi-induced fibrinolysis...
  68. ncbi Plasminogen K5 activates mitochondrial apoptosis pathway in endothelial cells by regulating Bak and Bcl-x(L) subcellular distribution
    Xiaoqiong Gu
    Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou 510080, Guangdong Province, China
    Apoptosis 16:846-55. 2011
    b>Plasminogen Kringle 5(K5) is a proteolytic fragment of plasminogen, which displays potent anti-angiogenic activities...
  69. ncbi Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Germany
    J Infect Dis 207:594-603. 2013
    ..Recombinant Gpd2 binds factor Hand and FHL-1, mainly via short consensus repeat 7; and binds plasminogen, via lysine residues...
  70. pmc Bacterial plasminogen receptors: mediators of a multifaceted relationship
    Martina L Sanderson-Smith
    Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    J Biomed Biotechnol 2012:272148. 2012
    Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell surface...
  71. pmc A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides
    Andrew Hollands
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:40891-7. 2012
    ..Through the secreted plasminogen activator streptokinase (Ska), GAS activates human plasminogen into plasmin and binds it to the bacterial ..
  72. pmc The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system
    C M Swaisgood
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Cleveland Clinic Foundation, OH, USA
    Am J Pathol 157:177-87. 2000
    ..the effect of bleomycin, an agent that induces the development of pulmonary fibrosis, in mice deficient for plasminogen (Pg(-)(/-)), urokinase (u-PA(-)(/-)), urokinase receptor (u-PAR(-)(/-)), or tissue plasminogen activator (t-PA(-..
  73. ncbi Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface
    Lisa M Seymour
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Cell Microbiol 14:81-94. 2012
    ..Although M. hyopneumoniae cells bind plasminogen, the identification of plasminogen-binding surface proteins and the biological ramifications of acquiring ..
  74. ncbi Plasminogen deficiency
    V Schuster
    Hospital for Children and Adolescents, Medical Faculty of Leipzig University, Liebigstrasse 20a, Leipzig, Germany
    J Thromb Haemost 5:2315-22. 2007
    b>Plasminogen (plg) deficiency has been classified as (i) hypoplasminogenemia or 'true' type I plg deficiency, and (ii) dysplasminogenemia, also called type II plg deficiency...
  75. ncbi In vitro evidence for immune evasion activity by human plasmin associated to pathogenic Leptospira interrogans
    Monica L Vieira
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil 1500, 05503 900 Sao Paulo, SP, Brazil
    Microb Pathog 51:360-5. 2011
    ..In a previous work, we demonstrated the ability of leptospires to bind human plasminogen (PLG), that after treatment with activators, conferred plasmin (PLA) activity on the bacteria surface...
  76. ncbi Plasminogen binding and cancer: promises and pitfalls
    Marie Ranson
    Department of Biological Sciences and Institute for Biomolecular Sciences, University of Wollongong, Australia, 2522
    Front Biosci 8:s294-304. 2003
    The urokinase plasminogen activation system is a key modulator of the tissue remodeling processes required for tumor cell invasion and metastasis...
  77. ncbi Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a
    S B Hawley
    Department of Vascular Biology CVN 26, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:179-86. 2001
    The plasminogen receptors responsible for enhancing cell surface-dependent plasminogen activation expose COOH-terminal lysines on the cell surface and are sensitive to proteolysis by carboxypeptidase B (CpB)...
  78. ncbi High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5
    Xia Yang
    Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    J Cell Mol Med 14:2519-30. 2010
    Kringle 5(K5) is the fifth kringle domain of human plasminogen and its anti-angiogenic activity is more potent than angiostatin that includes the first four kringle fragment of plasminogen...
  79. ncbi DnaK from Bifidobacterium animalis subsp. lactis is a surface-exposed human plasminogen receptor upregulated in response to bile salts
    Marco Candela
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    Microbiology 156:1609-18. 2010
    ..Recently, for the probiotic strain B. animalis subsp. lactis BI07, a dose-dependent plasminogen-binding activity was demonstrated and five putative plasminogen-binding proteins were identified...
  80. ncbi Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells
    Natasa Obermajer
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Int J Biochem Cell Biol 41:1685-96. 2009
    ..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X...
  81. ncbi Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity
    Diana Barthel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    J Immunol 188:379-85. 2012
    Pathogenic microbes acquire the human plasma protein plasminogen to their surface...
  82. ncbi The X-ray crystal structure of full-length human plasminogen
    Ruby H P Law
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800 Australia
    Cell Rep 1:185-90. 2012
    b>Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin...
  83. pmc The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release
    Hongdong Bai
    Department of Medicine, University of California, San Diego, La Jolla, California 92037, USA
    J Biol Chem 286:33125-33. 2011
    ..Here, we investigated the expression and subcellular localization of Plg-R(KT), a novel plasminogen receptor, and its role in catecholaminergic cell plasminogen activation and regulation of catecholamine release...
  84. ncbi The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin
    K C Robbins
    J Biol Chem 242:2333-42. 1967
  85. ncbi Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity
    Xia Yang
    Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    Cancer Biol Ther 5:399-405. 2006
    b>Plasminogen kringle 5 (K5), a proteolytic fragment of plasminogen, is an endogenous angiogenic inhibitor. We have previously shown that K5 inhibits ischemia-induced retinal neovascularization in a rat model...
  86. ncbi The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains
    Martina L Sanderson-Smith
    School of Biological Sciences, University of Wollongong, Northfields Avenue, New South Wales 2522, Australia
    J Biol Chem 281:25965-71. 2006
    Subversion of the plasminogen activation system is implicated in the virulence of group A streptococci (GAS)...
  87. pmc Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin
    Jamal Stie
    Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Microbiology 158:240-58. 2012
    ..b>Plasminogen is a plasma-enriched zymogen that can passively coat the surface of blood-borne pathogens and, upon conversion ..
  88. ncbi Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    Marc Tjwa
    Vesalius Research Center, VIB, Leuven, Belgium
    J Cell Mol Med 13:4587-95. 2009
    ..Here, we report the involvement of the plasminogen (Plg) system in the haematopoietic recovery following chemotherapy...
  89. pmc Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor
    Herbert B Schiller
    Department of Molecular Immunology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, A 1090 Vienna, Austria
    Mol Biol Cell 20:745-56. 2009
    ..We report here that RNA interference with M6P/IGF2R expression in urokinase-type plasminogen activator (uPA)/urokinase-type plasminogen activator receptor (uPAR) expressing human cancer and endothelial ..
  90. ncbi Domain interactions between streptokinase and human plasminogen
    J A Loy
    Protein Studies Program and Crystallography Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 40:14686-95. 2001
    Plasmin (Pm), the main fibrinolytic protease in the plasma, is derived from its zymogen plasminogen (Plg) by cleavage of a peptide bond at Arg(561)-Val(562)...
  91. pmc Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen
    Annekatrin Seling
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul Ehrlich Str 40, D 60596 Frankfurt, Germany
    Infect Immun 78:39-48. 2010
    ..The mutation of His-79 to Arg did not inhibit binding of plasminogen, another known ligand of this group of borrelial outer-surface proteins.
  92. ncbi Surface localized and extracellular Glyceraldehyde-3-phosphate dehydrogenase of Bacillus anthracis is a plasminogen binding protein
    Sumit Kumar Matta
    Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
    Biochim Biophys Acta 1804:2111-20. 2010
    ..anthracis. Human plasminogen predominantly interacted with the rGapA isoform at physiological concentrations and the interaction was found ..
  93. ncbi Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogen
    Veera Hurmalainen
    General Microbiology, Faculty of Biosciences, PO Box 56, FIN00014 University of Helsinki, Finland
    Microbiology 153:1112-22. 2007
    The abundant proteolytic plasminogen (Plg)/plasmin system is important in several physiological functions in mammals and also engaged by a number of pathogenic microbial species to increase tissue invasiveness or to obtain nutrients...
  94. ncbi Schistosoma bovis: plasminogen binding in adults and the identification of plasminogen-binding proteins from the worm tegument
    Alicia Ramajo-Hernández
    Unidad de Patología Animal, Instituto de Recursos Naturales y Agrobiologia de Salamanca, Consejo Superior de Investigaciones Cientificas, Spain
    Exp Parasitol 115:83-91. 2007
    ..The aim of this work was to investigate the ability of adult S. bovis worms to interact with plasminogen, a central component in the host fibrinolytic system...
  95. ncbi Plasminogen activation and cancer
    Keld Danø
    Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Thromb Haemost 93:676-81. 2005
    ..Thus, the generation of plasmin involves the pro-enzyme plasminogen, the urokinase type plasminogen activator uPA and its pro-enzyme pro-uPA, the uPA inhibitor PAI-1, the cell ..
  96. ncbi Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase
    Roser Lopez-Alemany
    Centre d Oncologia Molecular C O M, Institut de Recerca Oncolgica IRO, Barcelona, Spain
    Am J Hematol 72:234-42. 2003
    ..The binding of plasminogen to leukocytic cell lines induces a 30- to 80-fold increase in the rate of plasminogen activation by tissue-type ..
  97. ncbi Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis
    Wendy Xolalpa
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, D F, Mexico
    Proteomics 7:3332-41. 2007
    Binding and activation of human plasminogen (Plg) to generate the proteolytic enzyme plasmin (Plm) have been associated with the invasive potential of certain bacteria...
  98. ncbi Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase
    Lynette M Kilpatrick
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Blood 108:2616-23. 2006
    uPA (urokinase-type plasminogen activator) activates plasminogen with high efficiency when bound to its cellular receptor uPAR, but only after a prolonged lag phase during which generated plasmin activates pro-uPA...
  99. pmc The novel leptospiral surface adhesin Lsa20 binds laminin and human plasminogen and is probably expressed during infection
    Renata Siqueira Mendes
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Infect Immun 79:4657-67. 2011
    ..proteins were evaluated for their capacity to attach to extracellular matrix (ECM) components and to plasminogen. The leptospiral protein encoded by LIC11469, named Lsa20 (leptospiral surface adhesin of 20 kDa), binds to ..
  100. pmc Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen
    Ashutosh Verma
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, MN 469 Chandler Medical Center, Lexington, KY 40536 0298, USA
    Infect Immun 78:2053-9. 2010
    ..Studies from our laboratories and another have demonstrated that L. interrogans can acquire host plasminogen on its surface...
  101. pmc Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e18119. 2011
    ..anthracis spores, and found that plasminogen (PLG) is a major surface-bound protein...

Research Grants68

  1. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..and adipocytokines that represent insulin resistance (adiponectin, leptin, resistin, tumor necrosis factor-1, plasminogen activator inhibitor-1) and inflammation (C-reactive protein) measured in fasting blood...
  2. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..There is strong evidence that annexin A2, a receptor for tissue plasminogen activator (tPA) and plasminogen, and toll-like receptor 4 (TLR-4), a receptor for bacterial lipopolysaccharide (..
  3. Metabolic regulation of diabetic nephropathy
    Karen Block; Fiscal Year: 2013
    ..signaling pathway and inhibits protein degradation by inducing inhibitors of matrix-degrading enzymes such as plasminogen activator inhibitor-1 (PAI-I)...
  4. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..suppressor FOXO1, which is involved in the control of lifespan and cell senescence and by the up-regulation of plasminogen activator inhibitor (PAI)-1 and matrix metalloproteinase (MMP)-1, two secreted markers of cell senescence and ..
  5. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
  6. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..A significant association of urokinase plasminogen activator (uPA) and matrix metalloprotease-9 (MMP-9) expression with survival and M-stage indicates that these ..
  7. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..Thrombolytic therapy with tissue plasminogen activator (tPA) acts to increase blood flow to the ischemic tissue and is the only approved treatment for acute ..
  8. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..One of these virulence factors, a membrane-embedded surface plasminogen activator (Pla), a member of the omptin protease family, facilitates dissemination of Y...
  9. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..Ligands that bind directly to LRP-1, including tissue-type plasminogen activator, activated 12-macroglobulin, and matrix metalloprotease-9, activate cell-signaling pathways leading ..
  10. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..outcome of activated alveolar epithelium is the production of potent fibrogenic molecules as tissue factor and plasminogen activator inhibitors that may generate an anti-fibrinolytic intraalveolar environment that facilitate an ..
  11. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
    ..During the previous funding period, we discovered a novel role for the urokinase-type plasminogen activator receptor (uPAR) in the regulation of fibronectin matrix assembly in connective tissue cells...
  12. PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..by sickle erythroid cells, induces expression of the potent pulmonary vasoconstrictor ET-1, and a procoagulant, plasminogen activator inhibitor-1 (PAI-1), from human pulmonary microvascular endothelial cells (HPMVEC)...
  13. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..Thrombolysis with tissue plasminogen activator (tPA) promotes adverse vascular events that limit the therapeutic window of stroke to three hours...
  14. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..The current regimen, including tissue plasminogen activator, aspirin, clopidogrel and heparin, still induces inadequate coronary reperfusion in 30-40% of ..
  15. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    ..b) coagulation activation in the CEES inhalation and chlorine models, and c) efficacy of tPA (tissue-type plasminogen activator) in late rescue, starting 4h after CEES inhalation...
  16. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..Urokinase and tissue plasminogen activator (uPA and tPA) are serine proteases whose contributions to the regulation of cerebral hemodynamics are ..
  17. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..Tissue-type plasminogen activator or t-PA is the initial protease of this pathway and is released from the vasculature in response to ..
  18. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..The deposition of fibrin is enhanced by the antifibrinolytic activity of plasminogen activator inhibitor-1 (PAI-1), a plasma protein the expression of which is induced by the transcription factor, ..
  19. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..It is known from humans treated with tissue plasminogen activator that ischemic tissue can be salvaged from infarction by thrombolytic CBF restoration...
  20. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
    ..Currently, there is only one FDA-approved treatment for stroke;Tissue Plasminogen Activator, which can lead to severe brain hemorrhage in up to 7% of treated patients...
  21. Renin-angiotensin and fibrinolysis interaction in humans
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..nitric oxide increases muscle glucose uptake in humans;however, nitric oxide also decreases vascular tissue plasminogen activator release through a cGMP-independent mechanism...
  22. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The plasminogen (Plg) system is the major enzymatic network responsible for the dissolution of clots...
  23. Cell Surface Plasminogen Activation and Hypertension
    Robert J Parmer; Fiscal Year: 2013
    ..This proposal is based on our proteomics-based discovery of a new protein, the plasminogen receptor, Plg-RKT, which markedly enhances the activation of the zymogen plasminogen to plasmin, as well as ..
  24. Inflammation and Injury in Obesity Hypertension in African American Adolescents
    Bonita Falkner; Fiscal Year: 2010
    ..normal BP (ONBP) indicate a pro-inflammatory profile in OHBP (lower adiponectin, higher interleukin 6, higher plasminogen activator inhibitor-1) compared to the reverse pattern in ONBP...
  25. GAS Switch from Colonizing Bacterium to Invasive Pathogen
    Victor Nizet; Fiscal Year: 2012
    ..factor mutants for neutrophil resistance, invasive phenotype switching, and systemic infection in the humanized plasminogen mouse, defining those innate immune resistance factors necessary for systemic virulence...
  26. PLASMINOGEN AND PLASMIN: STRUCTURE AND FUNCTION
    Francis J Castellino; Fiscal Year: 2013
    ..g., PAM) proteins are essential for this function in large part through their ability to bind to host human plasminogen (hPg) directly (PAM), or, indirectly (M1), via fibrinogen (Fg)/fibrin (Fn)...
  27. Vitamin D deficiency and treatment in male veterans at risk for diabetes
    Elena Barengolts; Fiscal Year: 2013
    ..interleukin-6 and tumor necrosis factor-alpha), of cardiovascular disease (sensitive C-reactive protein and plasminogen activator inhibitor-1), and adipokines (adiponectin and leptin)...
  28. Plasminogen activator inhibitor-1 in tumor progression and metastasis
    Yves A DeClerck; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasminogen activator inhibitor-1 (PAI-1) is a member of the family of endogenous serine protease inhibitors (serpins) that controls the activation of plasminogen into plasmin by tissue and urokinase ..
  29. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..Recent studies on a known extracellular matrix-regulating protease, tissue-type plasminogen activator (t-PA), have shown that it can play a role in modulating tissue fibrosis development [1-3]...
  30. Targeted Therapy of Triple Negative Breast Cancer Using Theranostic Nanoparticles
    Lily Yang; Fiscal Year: 2013
    ..First, urokinase plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) will be validated as molecular targets ..
  31. PAI-1 and Vitronectin in Failure of Coronary Revascularization
    William P Fay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue- and urinary-type plasminogen activators...
  32. Identification of New Antigens for a Plague Vaccine
    Ashok K Chopra; Fiscal Year: 2013
    ..Aim 1 is to generate double mutants of Y. pestis CO92 in which genes encoding plasminogen-activating protease (pla), pnp, and two other predominant exoribonucleases (e.g...
  33. MATRIX MEDIATORS OF WOUND HEALING
    Paul J Higgins; Fiscal Year: 2010
    b>Plasminogen activator inhibitor type-1 (PAI-1) is the major physiologic regulator of the plasmin-based pericellular proteolytic cascade and a critical element in pathologic angiogenesis in vivo. PAI-1 controls stromal proteolysis (i.e...
  34. Role of Fibrinolytic System in Vein Graft Remodeling
    William P Fay; Fiscal Year: 2013
    ..b>Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor and a major regulator of fibrinolysis and cell ..
  35. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2009
    ..Additionally, the kallikrein protease system is postulated to interact with plasminogen activator (PA) system in the CNS - another major protease system that regulates neuronal function in normal and ..
  36. Neonatal Anesthetic Neurotoxicity
    Piyush M Patel; Fiscal Year: 2013
    ..b>Plasminogen, the precursor to plasmin, is proteolytically cleaved by tPA, a protease released from pre-synaptic vesicles...
  37. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2012
    ..First, HIF2( and USF2 share a large number of common target genes. An example of such gene is the plasminogen activator inhibitor 1 (PAI1)...
  38. Endogenous and exogenous protection of the BBB in stroke
    Richard F Keep; Fiscal Year: 2013
    ..g. hemorrhagic transformation is a major limiting factor for the use of tissue plasminogen activator-induced reperfusion therapy for ischemic stroke)...
  39. Technology to improve the assessment of tissue-associated protein biomarkers
    JEFFREY THOMAS MASON; Fiscal Year: 2013
    ..Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) have been validated at the highest level of ..
  40. Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke
    Irina Y Sazonova; Fiscal Year: 2012
    ..Despite the testing of over 70 agents in clinical trials, only one drug, the recombinant tissue plasminogen activator (TPA), has been approved by the FDA for the treatment of ischemic stroke...
  41. Regulation of Pal-1 in Atherosclerosis and Thrombosis
    Yolanda M Fortenberry; Fiscal Year: 2013
    ..and hypertension. Elevated plasma levels of the serine protease inhibitor, plasminogen activatoMnhibitor-1, (PAI- 1) are correlated with these'risk factors and:several other thrombotic ..
  42. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..long-lasting ss-agonist formoterol and the type 4 phosphodiesterase inhibitor rolipram;stimulation of plasminogen activation with urokinase-type plasminogen activator or the plasminogen activator inhibitor-1 inhibitor ..
  43. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
    ..g. tissue factor and plasminogen activator inhibitor-1) through its ability to reduce NF?B activity...
  44. Ah Receptor Anatomy: Implications for Dioxin Toxicity
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2011
    ..will examine the molecular basis and relative contribution of cyclin-dependent kinase 2 (CDK2) inhibi- ion and plasminogen activator inhibitor-1 (PAI-1) expression on liver regeneration...
  45. Matrix Metalloproteinase Inhibitors in Stroke
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    Stroke is the major neurological illness and recombinant tissue type plasminogen activator (rtPA) is the only approved treatment. Use of rtPA is limited to three hours after stroke because of the risk of intracerebral hemorrhage...
  46. Interactions of Lipoproteins and Cells in Diabetes Mellitus
    RICHARD LOUIS KLEIN; Fiscal Year: 2013
    ..HDL3, which in normal subjects contains higher concentrations of S1P than HDL2, both stimulate the release of plasminogen activator inhibitor-1 (PAI-1) from adipocytes and, importantly, that circulating S1P concentrations are ..
  47. Pathogenesis of Lymphangioleiomyomatosis
    Lucia Schuger; Fiscal Year: 2010
    ..of key extracellular matrix (ECM)-degrading enzymes including several metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)...
  48. Ac-SDKP for Treatment of Acute Stroke
    Zheng Gang Zhang; Fiscal Year: 2013
    ..Tissue plasminogen activator (tPA) is the only drug approved by the Food and Drug Administration (FDA) for treatment of acute ..
  49. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
    ..extracellular matrix;MMP-7, matrilysin, the smallest member with broad proteolytic activity;and urokinase-type plasminogen activator (uPA) that involves the activation of MMPs...
  50. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..contrast agents (UCA) potentiate the effect of sonothrombolysis, without or in combination with tissue Plasminogen Activator (tPA)...
  51. Treatment and Risk Factor Determinants of Cardiovascular Outcomes in BARI 2D
    Maria Mori Brooks; Fiscal Year: 2013
    ..During the five- year follow-up, plasminogen activator inhibitor-1 (PAI-1), C-reactive protein (CRP), fibrinogen, and D-dimer were lower in the insulin ..
  52. Corneal Expression and Function of Slurp1
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Though the secreted Ly6/urokinase type plasminogen activator receptor (uPAR) related protein-1 (Slurp1) is one of the most abundantly expressed proteins in the cornea and is secreted into the tear ..
  53. Deleted in liver cancer 1 (DLC1) in liver development and disease
    Yi Ping Shih; Fiscal Year: 2013
    ..I have also discovered that loss of DLC1 enhances angiogenesis by upregulating VEGF and plasminogen activator inhibitor 1 (PAI-1) expression...
  54. Role of Hyperglycemia in Intracerebral Hemorrhage
    Edward P Feener; Fiscal Year: 2013
    ..early and long-term mortality, occurrence of symptomatic ICH in stroke patients treated with intravenous tissue plasminogen activator (tPA), and increased hematoma volume and expansion, which are significant and independent ..
  55. Real-time imaging of tPA fluorescent hybrids in hippocampal neurons
    Janis E Lochner; Fiscal Year: 2011
    ..the mechanisms that facilitate the synaptic secretion of an important regulated secretory protein, tissue-type plasminogen activator (tPA), from DCGs in hippocampal neurons...
  56. Urokinase plasminogen activator receptor associated protein and acute lung injury
    Michael Bundesmann; Fiscal Year: 2010
    ..Second, it binds uPAR (urokinase plasminogen activator receptor), and may decrease uPA (urokinase plasminogen activator) activation...
  57. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..Matriptase activates several inactive protease zymogens, including urokinase plasminogen activator (uPA) and prostasin, and also activates pro-hepatocyte growth factor (HGF), which serves as a ligand ..
  58. Weibel-Palade Bodies: roles in thrombosis, inflammation and stroke
    Denisa D Wagner; Fiscal Year: 2013
    ..a) VWF and ADAMTS13 in stroke, b) Therapeutic effect of rADAMTS13 in ischemic stroke and comparison to tissue plasminogen activator (tPA). The application heavily relies on genetically modified mice, all available to our laboratory...
  59. Role of the Plasminogen Activator Protease during Pneumonic Plague
    Wyndham W Lathem; Fiscal Year: 2013
    ..We have shown that the bacterial virulence factor Pla, the plasminogen activator protease, is essential for Y...
  60. Vascular protection by epoxide hydrolase inhibition in cerebral ischemia
    Alexis N Simpkins; Fiscal Year: 2010
    ..Although thrombolysis with tissue plasminogen activator is the only treatment for ischemic stroke, most patients are not candidates for receiving ..
  61. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    ..published data from our laboratory indicates that (a) BMP-4 inhibits TGF-22 stimulation of fibronectin (FN) and plasminogen activator inhibitor-1 (PAI-1) secretion by cultured TM cells and (b) gremlin, a BMP antagonist is upregulated ..
  62. Ah receptor transcriptional regulation through a novel DNA binding site
    SHELLY RENEE WILSON; Fiscal Year: 2012
    ..Preliminary evidence examining TCDD induction of plasminogen activator inhibitor-1 (PAI-1), a key protein in liver regeneration, exposed a novel AhR-dependent regulatory ..
  63. PA/PLASMIN/GELATINASE CASCADE IN DIABETIC NEPHROPATHY
    WILLIAM BARICOS; Fiscal Year: 2000
    ..Mesangial cells produce several agents potentially involved in matrix degradation including plasminogen activator(s), latent gelatinase and the gelatinase inhibitors, TIMP-1 and TIMP-2 (tissue inhibitor of ..
  64. HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPY
    BARBARA ALEVRIADOU; Fiscal Year: 2000
    ..Administration of thrombolytic agents, such as streptokinase, urokinase or tissue-type plasminogen activator (t-PA), is standard treatment for acute myocardial infarction patients...
  65. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..of plasmin to surface binding proteins, as well as a more complicated pathway involving two host proteins (plasminogen and fibrinogen) and two bacterial proteins (the secreted bacterial plasminogen activator, streptokinase (SK), ..
  66. PLATELETS, PLATELET AGGREGATES & PLASMINOGEN ACTIVATION
    Joseph Loscalzo; Fiscal Year: 1991
    ..We have demonstrated in preliminary work that tissue plasminogen activator added to platelets induced to aggregate in plasma facilitates dispersal of the aggregates, or ..
  67. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    ..One set of genes regulated by LH and requisite for the process of ovulation are the plasminogen activator (PA) and plasminogen activator inhibitor (PAI) genes...
  68. STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMIN
    Francis Castellino; Fiscal Year: 1999
    ..on the protein chemistry, enzymology, immunochemistry, spectroscopic properties and molecular biology of human plasminogen, tissue plasminogen activator, urokinase, streptokinase and fibrin(ogen)...