steroid 16 alpha hydroxylase

Summary

Summary: A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.

Top Publications

  1. ncbi Impact of transgene expression on drug metabolism following systemic adenoviral vector administration
    Shellie M Callahan
    College of Pharmacy, Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712 1074, USA
    J Gene Med 8:566-76. 2006
  2. ncbi Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat1
    S Bai
    4 Address correspondence to: Lane J. Brunner, Ph.D, Pharmaceutics Division, PHR 4.214E, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712-1074
    Transplantation 71:1585-92. 2001
  3. ncbi Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily
    N T Ha-Duong
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, , 45, , 75270 Paris Cedex 06, France
    J Med Chem 44:3622-31. 2001
  4. ncbi Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19
    K W Krausz
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg. 37, Bethesda, MD 20892, USA
    Drug Metab Dispos 29:1410-23. 2001
  5. ncbi Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9
    X Wen
    Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu 4, FIN-00290 Helsinki, Finland
    Drug Metab Dispos 29:1359-61. 2001
  6. ncbi Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes
    Jun Sheng Wang
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    J Pharmacol Exp Ther 302:43-9. 2002
  7. ncbi Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama)
    L Skalova
    Faculty of Pharmacy, Charles University, Heyrovskeho 1203, CZ 50005, Hradec Kralove, Czech Republic
    Chem Biol Interact 137:155-67. 2001
  8. ncbi Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations
    O V Olesen
    Department of Biological Psychiatry, Psychiatric University Hospital, Risskov, Denmark
    J Clin Pharmacol 41:823-32. 2001
  9. ncbi Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism
    Karthik Venkatakrishnan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Biopharm Drug Dispos 23:183-90. 2002
  10. ncbi P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage
    Eva Kaergel
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:273-9. 2002

Detail Information

Publications123 found, 100 shown here

  1. ncbi Impact of transgene expression on drug metabolism following systemic adenoviral vector administration
    Shellie M Callahan
    College of Pharmacy, Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712 1074, USA
    J Gene Med 8:566-76. 2006
    ..The objective of these studies was to determine how the transgene cassette influences CYP expression and function...
  2. ncbi Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat1
    S Bai
    4 Address correspondence to: Lane J. Brunner, Ph.D, Pharmaceutics Division, PHR 4.214E, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712-1074
    Transplantation 71:1585-92. 2001
    ..Nephrotoxicity caused by combination therapy is due to CsA elevating levels of SRL or by SRL itself. Concurrent administration of CsA and SRL in transplant patients should be performed with caution...
  3. ncbi Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily
    N T Ha-Duong
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, , 45, , 75270 Paris Cedex 06, France
    J Med Chem 44:3622-31. 2001
    ..Thus, compound 11 (R(1) = NH(2), R(2) = (CH(2))(2)CH(CH(3))(2)) appears to be particularly interesting for that purpose as its IC(50) value for CYP 2C8 is low (3 microM) and 20-fold smaller than those found for CYP 2C9 and 2C19...
  4. ncbi Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19
    K W Krausz
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg. 37, Bethesda, MD 20892, USA
    Drug Metab Dispos 29:1410-23. 2001
    ..The mAb system offers large potential for studies of cytochrome P450 function useful in drug discovery and reduces the possibility of adverse drug reactions due to polymorphisms and drug interactions...
  5. ncbi Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9
    X Wen
    Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu 4, FIN-00290 Helsinki, Finland
    Drug Metab Dispos 29:1359-61. 2001
    ..Gemfibrozil may also impair clearance of CYP2C19 and CYP1A2 substrates, but inhibition of other CYP isoforms is unlikely...
  6. ncbi Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes
    Jun Sheng Wang
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    J Pharmacol Exp Ther 302:43-9. 2002
    ..The present findings suggest that the addition of Hsa and Hlc to microsomal incubation media may yield enzyme kinetic estimates more comparable with in vivo results...
  7. ncbi Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama)
    L Skalova
    Faculty of Pharmacy, Charles University, Heyrovskeho 1203, CZ 50005, Hradec Kralove, Czech Republic
    Chem Biol Interact 137:155-67. 2001
    ..The comparison of induction effect of ivermectin in rat, mouflon and fallow deer also demonstrates the inter-species differences in inducibility of CYP enzymes...
  8. ncbi Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations
    O V Olesen
    Department of Biological Psychiatry, Psychiatric University Hospital, Risskov, Denmark
    J Clin Pharmacol 41:823-32. 2001
    ..The rate of other metabolic routes mediated by CYP2D6 only corresponded to about one fifth of the CYP2D6 catalyzed N-demethylation rate...
  9. ncbi Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism
    Karthik Venkatakrishnan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Biopharm Drug Dispos 23:183-90. 2002
    ..These factors should be considered when this formulation is used as an in vitro model in human liver microsomal drug metabolism studies...
  10. ncbi P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage
    Eva Kaergel
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:273-9. 2002
    ..Because the products of AA epoxygenation have anti-inflammatory properties, this alteration may contribute to uncontrolled renal inflammation, which is a major cause of renal damage in dTGR...
  11. pmc In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)
    X Wen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Br J Clin Pharmacol 52:547-53. 2001
    ..Co-administration of high doses of valproic acid with drugs that are primarily metabolized by CYP2C9 may result in significant drug interactions...
  12. ncbi Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine
    G M Giancarlo
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Eur J Clin Pharmacol 57:31-6. 2001
    ..CONCLUSIONS: Formation of HPPH from PPH is mediated exclusively by CYP2C9 and 2C19, with CYP2C9 playing the major role...
  13. ncbi Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9
    C C Tsao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 40:1937-44. 2001
    ....
  14. ncbi Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Drug Metab Dispos 31:833-6. 2003
    ..However, it appears that sulfaphenazole can be used as a selective inhibitor for rat CYP2C6. In addition, furafylline may also be a relatively selective inhibitor for rat CYP1A2...
  15. ncbi Prevention of latently expressed CYP2C11, CYP3A2, and growth hormone defects in neonatally monosodium glutamate-treated male rats by the N-methyl-D-aspartate receptor antagonist dizocilpine maleate
    Antje Kaufhold
    Laboratories of Biochemistry, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6048, USA
    J Pharmacol Exp Ther 302:490-6. 2002
    ..e., hypothalamic) damage produced at the time of MSG exposure. The irreversibility of the P450 damage is described as resulting from secondary defects initially induced by the neuronal lesions...
  16. ncbi Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors
    M H Nelson
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, 8-101 WDH, 308 Harvard Street, Minneapolis, MN 55455, USA
    Epilepsy Res 44:71-82. 2001
    ..In light of typical SSRI blood levels observed in patients, this study also suggests that the risk of a SSRI-phenytoin interaction is highest with fluoxetine and norfluoxetine, and less likely with sertraline and paroxetine...
  17. ncbi Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline
    G Gervasini
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Pharmacogenetics 11:29-37. 2001
    ..The possible clinical implications of this modulation are discussed...
  18. ncbi Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack
    Nabil J Alkayed
    Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Stroke 33:1677-84. 2002
    ..We tested the hypothesis that experimental TIA induces expression of P450 2C11, an arachidonic acid epoxygenase that produces vasodilator epoxyeicosatrienoic acids, leading to increased tissue perfusion and reduced stroke damage...
  19. ncbi In vitro cytochrome P450-mediated hepatic activities for five substrates in specific pathogen free chickens
    W F Khalil
    Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo183-8509, Japan
    J Vet Pharmacol Ther 24:343-8. 2001
    ..On the other hand, tolbutamide hydroxylation was markedly higher in chickens than in dogs...
  20. ncbi Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants
    Ieva Stupans
    Center for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, SA 5000, Australia
    J Agric Food Chem 50:2464-9. 2002
    ..It was also demonstrated that the presence of two phenolic groups is not always associated with antioxidant activity...
  21. ncbi Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes
    Nu He
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Eur J Clin Pharmacol 57:847-51. 2002
    ..To screen the inhibitory effects of H1-antihistamines on hepatic bufuralol 1'-hydroxylation and on tolbutamide 4-methylhydroxylation in human liver microsomes...
  22. ncbi Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes
    Mitsuo Miyazawa
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
    Drug Metab Dispos 30:602-7. 2002
    ..Species-related differences exist in the oxidations of limonenes in CYP2B subfamily in rats and humans...
  23. ncbi Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship
    Thierry Cresteil
    Centre National de la Recherche Scientifique Unité Mixte Recherche 8532, Villejuif, France
    Drug Metab Dispos 30:438-45. 2002
    ....
  24. ncbi Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation
    Jackie L Miller
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706 1102, USA
    Eur J Clin Pharmacol 58:69-72. 2002
    ..To determine whether the antiprotozoal drug atovaquone inhibits the cytochrome P(450) (CYP)2C9-mediated metabolism of sulphamethoxazole (SMX) to its potentially harmful hydroxylamine metabolite (SMX-HA) in vitro...
  25. ncbi Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans
    Ji Hong Shon
    Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, South Korea
    Pharmacogenetics 12:111-9. 2002
    ..The in-vivo contribution of CYP2C19 to tolbutamide 4-methylhydroxylation appears to be minor in humans. This suggests that, at least in vivo, tolbutamide remains a selective probe for measuring CYP2C9 activity in humans...
  26. ncbi Multiple mechanisms in indomethacin-induced impairment of hepatic cytochrome P450 enzymes in rats
    Yasuhiro Masubuchi
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Gastroenterology 122:774-83. 2002
    ..Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo...
  27. ncbi Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase
    Gail D Anderson
    Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
    J Gend Specif Med 5:25-33. 2002
    ..However, genetics also controls the amount (or activity) of the enzymes. Sex-dependent differences have been demonstrated for several CYP isoenzymes and for UGT. Ethnicity also appears to play a role in the activity of these enzymes...
  28. ncbi Phosphonate O-deethylation of [4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester, a lipoprotein lipase-promoting agent, catalyzed by cytochrome P450 2C8 and 3A4 in human liver microsomes
    Yujiro Morioka
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Tokushima, Japan
    Drug Metab Dispos 30:301-6. 2002
    ..The selectivity of CYP2C8 in catalyzing phosphonate O-deethylation indicates that coadministration of drugs that are metabolized by the same enzyme requires careful consideration...
  29. ncbi Altered cytochrome P450 and P-glycoprotein levels in rats during simulated weightlessness
    Shirley K Lu
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, 78712 1074, USA
    Aviat Space Environ Med 73:112-8. 2002
    ....
  30. ncbi Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate
    Xue Qing Li
    Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca Research and Development, Molndal, Sweden
    J Pharmacol Exp Ther 300:399-407. 2002
    ..These data show that CYP2C8 is the main hepatic isoform responsible for the metabolism of AQ. The specificity, high affinity, and high turnover make AQ desethylation an excellent marker reaction for CYP2C8 activity...
  31. ncbi Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression
    Ravindra N Dhir
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104 6048, USA
    Drug Metab Dispos 30:141-7. 2002
    ..These changes in GRF-induced, sexually dimorphic secretory growth hormone profiles and the accompanying decline in P450 expression levels may anticipate similar, but more profound, changes to occur during senescence...
  32. ncbi Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9
    Yoko Otake
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 30:103-5. 2002
    ..In addition, CYP1A1, although less efficient, was also able to oxidize the two flavonols. Thus, dietary flavonols are likely to undergo oxidative metabolism mainly in the liver but also extrahepatically...
  33. ncbi Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Environ Mol Mutagen 38:329-38. 2001
    ..These S. typhimurium strains may be useful not only for predicting the metabolic activation of promutagens catalyzed by human CYP but also for identifying the CYP form involved...
  34. ncbi In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11
    Jill S Warrington
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, MA 02111, USA
    Drug Metab Dispos 30:655-7. 2002
    ..P450 isoforms mediating sildenafil biotransformation differ substantially between humans and the male rat, thereby limiting the applicability of this species as a model for sildenafil metabolism and drug interactions in humans...
  35. ncbi Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe
    N Matsunaga
    Department of Pharmaceutics, Kyoritsu College of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 24:1305-10. 2001
    ..It was also demonstrated that the qg and amount of CYP are useful parameters in the PKCYP-test by constructing a physiologically-based pharmacokinetic model which was applied to the PKCYP-test...
  36. pmc Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats
    Ravindra N Dhir
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104 6048, USA
    Proc Natl Acad Sci U S A 100:15224-8. 2003
    ....
  37. ncbi Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver
    A Strom
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    Acta Endocrinol (Copenh) 118:314-20. 1988
    ..Northern blots showed that P-45016 alpha in the rat liver is pretranslationally regulated by the growth hormone secretory pattern. Southern blots indicated that few genes belong to the same P-450 gene family as P-45016 alpha...
  38. ncbi Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes
    Matthew A Cerny
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA
    Arch Biochem Biophys 436:265-75. 2005
    ....
  39. ncbi Allelic and functional variability of cytochrome P4502C9
    C R Bhasker
    Department of Clinical Pharmacology, Flinders University of South Australia, Australia
    Pharmacogenetics 7:51-8. 1997
    ..It is likely that functional changes occurring as a result of the Ile359Leu transition are responsible for the tolbutamide poor metabolizer phenotype...
  40. ncbi Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms
    R L Haining
    Department of Medicinal Chemistry, University of Washington, Seattle 98195, USA
    Arch Biochem Biophys 333:447-58. 1996
    ....
  41. ncbi Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver
    A Strom
    Department of Medical Nutrition, Huddinge University Hospital, Sweden
    DNA Cell Biol 13:805-19. 1994
    ..To date, the two silencer elements and possibly also the HNF-1-like element are the only functional elements defined in the CYP2C11 gene, and it is conceivable that induction of the gene involves derepression of the silencer elements...
  42. ncbi Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 22:367-76. 2007
    ..Thus, CYP2C11/13 could associate with UGTs, but the affinity is assumed to be weaker than that of CYP2B/3As. These results suggest that there is isoform specificity in the interaction between P450s and UGTs...
  43. ncbi Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol
    Toshiro Niwa
    Division of Natural Science, Osaka Kyoiku University, Kashiwara, Japan
    Biol Pharm Bull 25:235-8. 2002
    ..These results suggest that nonylphenol inhibits human hepatic CYPs, especially CYP2C9 and CYP2C19, and steroidogenic CYP17 activities...
  44. ncbi Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily
    N Ishida
    Suntory Institute for Biomedical Research, Osaka, Japan
    Biochem Biophys Res Commun 156:681-8. 1988
    ..2% and 99.0% similar in amino acid sequences, suggesting that they were virtually identical. CMF1a and CMF1b were different but 96.1% similar, and CMF3 was between 76% and 78% similar to other members of the rat P450IID family...
  45. pmc Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b
    N Ishida
    Rockefeller University Hospital, New York, NY 10021
    Nucleic Acids Res 17:6407. 1989
  46. ncbi Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
    G Luo
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Arch Biochem Biophys 357:45-57. 1998
    ..CYP2C38 and CYP2C40 were found in liver, brain, kidney, and intestine, with trace amounts in lung and heart, while CYP2C37 and CYP2C39 appeared to be liver specific...
  47. ncbi Eight cytochrome P450s catalyze vitamin D metabolism
    Yoshihiko Ohyama
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Front Biosci 9:3007-18. 2004
    ..The main focus of this review is to summarize the properties of individual P450 in light of their catalytic activities to understand their physiological significance...
  48. ncbi The human CYP2C locus: a prototype for intergenic and exon repetition splicing events
    C Finta
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, SE 141 57, Sweden
    Genomics 63:433-8. 2000
    ..In addition, CYP2C8 gene expression was found to generate a variety of scrambled RNA molecules including species that contained repetitions of certain exons...
  49. ncbi Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation
    Susumu Imaoka
    Department of Chemical Biology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Cancer Lett 203:117-25. 2004
    ..These results suggest that active oxygen produced by P450 oxidized genomic DNA and induction of P450 increased oxidative stress that may contribute to tumor initiation and promotion...
  50. ncbi Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
    Mehrdad Rahmaniyan
    Department of Medicine, Medical University of South Carolina, Strom Thurmond Research Building, Charleston, SC 29425, USA
    Am J Physiol Endocrinol Metab 288:E753-60. 2005
    ..It is concluded that CYP2C11 is a male-specific hepatic microsomal vitamin D 25-hydroxylase that hydroxylates vitamin D2, vitamin D3, 1alphaOHD2, and 1alphaOHD3. CYP2C11 is also a vitamin D 24-hydroxylase...
  51. ncbi Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2
    Christopher A Wiwi
    Division of Cell and Molecular Biology, Department of Biology Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 280:3259-68. 2005
    ....
  52. ncbi Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
    L C McSorley
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK
    Biochem Pharmacol 60:517-26. 2000
    ....
  53. ncbi Identification of the hepatic cytochrome P-450 isozymes induced and decreased by picloram
    G F Reidy
    National Occupational Health and Safety Commission, University of Sydney, NSW, Australia
    Biochem Pharmacol 37:1021-5. 1988
    ..Cytochrome P-450d is known to be a high spin haemoprotein...
  54. pmc cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates
    P G Zaphiropoulos
    Department of Medical Nutrition, Huddinge University Hospital, Sweden
    Proc Natl Acad Sci U S A 85:4214-7. 1988
    ..This relatively long period before P-450 15 beta and P-450 16 alpha mRNA induction is seen might indicate that protein factors mediating GH action are involved...
  55. ncbi Inflammation and sex hormone metabolism
    Martin Schmidt
    Institute of Biochemistry II, Hospital of the Friedrich Schiller University, 07740 Jena, Germany
    Ann N Y Acad Sci 1069:236-46. 2006
    ..The data discussed here suggest that therapy of RA patients may benefit from the use of nonaromatizable androgens and/or the use of aromatase inhibitors...
  56. ncbi Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17)
    Amanda C Swart
    Department of Biochemistry, University of Stellenbosch, South Africa Department of Reproductive and Developmental Sciences, University of Edinburgh Medical School, Scotland, UK
    Eur J Biochem 269:5608-16. 2002
    ..No 16alpha-hydroxylase and no lyase activity for 17alpha-hydroxyprogesterone. Sequence analyses showed that there are 28 different amino acid residues between human and baboon CYP17, primarily in helices F and G and the F-G loop...
  57. ncbi Marijuana extracts possess the effects like the endocrine disrupting chemicals
    Kazuhito Watanabe
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Toxicology 206:471-8. 2005
    ..01-1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana...
  58. pmc Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice
    Juan P Hernandez
    Biological Sciences, University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USA
    Toxicol Appl Pharmacol 216:186-96. 2006
    ..In conclusion, NP causes gender-specific P450 induction and therefore exposure to NP may cause distinct pharmacological and toxicological effects in males compared to females...
  59. doi Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity
    Mutsuko Hirata-Koizumi
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Drug Chem Toxicol 32:204-14. 2009
    ..5 mg/kg. These findings indicate that HDBB would have hepatic peroxisome proliferative activity, and the difference in susceptibility of male and female rats to this effect might lead to marked gender-related differences in HDBB toxicity...
  60. ncbi Characterization and regulation of sex-specific mouse steroid hydroxylase genes
    H Yoshioka
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Can J Physiol Pharmacol 68:754-61. 1990
    ..It appears, therefore, that the mouse P-450 gene families evolved through gene duplication and selective mutation to create new P-450s structurally as well as to establish novel regulatory elements for the gene expressions...
  61. ncbi Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction
    M J Melià
    Centre d Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Endocrinology 139:688-95. 1998
    ..These newly identified androgen-regulated genes will constitute very useful models for studying the nature of tissue-specific gene regulation by androgens...
  62. pmc Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans
    H L Bradlow
    Proc Natl Acad Sci U S A 82:6295-9. 1985
    ..These studies establish a relationship between genetics, hormonal factors, and murine mammary tumor virus, the three key factors in mammary tumorigenesis...
  63. ncbi [A patient with mitochondrial encephalomyopathy presenting gynecomastia with elevation of serum estriol level]
    Ryo Yamasaki
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:291-5. 2004
    ..Thus, it is of potential that estrogens increased locally in muscle tissues of the patients with mitochondrial encephalomyopathies protect muscle fibers from oxidative damage due to mitochondrial dysfunction...
  64. ncbi Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats
    Nichola M Thompson
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    Endocrinology 144:4859-67. 2003
    ..Thus, exposure to continuously elevated circulating ghrelin may be responsible for the suppression of GH secretion reported in rats after prolonged starvation...
  65. ncbi cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells
    C Biagini
    INSERM U75, Universite Rene Descartes, Paris, France
    Arch Biochem Biophys 326:298-305. 1996
    ....
  66. ncbi Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk
    Umit Yasar
    Carcinogenesis 23:665; author reply 667-8. 2002
  67. ncbi Effect of hemodialysis on hepatic cytochrome P450 functional expression
    Josée Michaud
    Service de Néphrologie et Centre de Recherche Guy Bernier, Hopital Maisonneuve Rosemont, Canada
    J Pharmacol Sci 108:157-63. 2008
    ..This is the first study to demonstrate that conventional hemodialysis acutely improves altered CYP functional expression observed in rat hepatocytes incubated with uremic human serum...
  68. ncbi Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein
    Bernard P Murray
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Mol Pharmacol 61:1146-53. 2002
    ..These findings with two monotopic ER hemoproteins, CYP2C11 and CYP3A4, and the polytopic ER protein HMGR attest to the remarkable mechanistic diversity of cellular proteolytic disposal of ER proteins...
  69. ncbi Development of a combined protein and pharmacophore model for cytochrome P450 2C9
    Marcel J de Groot
    Department of Molecular Informatics, Structure and Design, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, U K
    J Med Chem 45:1983-93. 2002
    ..The model has also been successful in explaining the differences in substrate specificity between CYP2C9 and CYP2C19...
  70. ncbi Effect of in vitro and in vivo treatment with mitomycin C on activities of CYP2D1/2, CYP2C11, and CYP1A2 in rat liver
    Fu rong Hao
    Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
    Yao Xue Xue Bao 39:897-903. 2004
    ..To evaluate the effect of in vitro and in vivo treatment with mitomycin C (MMC) on activities of CYP2D1/2, CYP2C1 , and CYP1A2 in the liver of male rats...
  71. ncbi Evaluation of potential losartan-phenytoin drug interactions in healthy volunteers
    Tracy L Fischer
    Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill 27599, USA
    Clin Pharmacol Ther 72:238-46. 2002
    ..Therefore there is the potential for significant concentration-related adverse effects when phenytoin is coadministered with other CYP2C9 substrates. Losartan, an antihypertensive agent, is also a substrate for CYP2C9...
  72. ncbi Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes
    Mitsuo Miyazawa
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
    Drug Metab Dispos 31:1049-53. 2003
    ....
  73. ncbi Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes
    Mingyue Liu
    Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 25:939-48. 2005
    ..HPC and EETs reduced astrocyte cell death, and P450 epoxygenase inhibition prevented protection by HPC. We conclude that HPC induces tolerance in astrocytes, at least in part, via HIF-1alpha-linked upregulation of P450 2C11...
  74. ncbi Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TR- and EHBR rats
    Deborah J Newton
    Department of Drug Metabolism, RY80 D100, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065, United States
    Life Sci 77:1106-15. 2005
    ..Thus, in addition to Mrp2 deficiency, differential expression of CYP isoforms and their potential impact on the metabolism and pharmacokinetics of compounds should be considered when interpreting data from these rat strains...
  75. ncbi A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5
    Santosh Kumar
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Biol Chem 278:17178-84. 2003
    ....
  76. doi A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase
    Amanda C Swart
    Department of Biochemistry, University of Stellenbosch, Stellenbosch 7600, South Africa
    J Steroid Biochem Mol Biol 119:112-20. 2010
    ..The smaller residue allows more flexibility of movement in the active pocket than Leu, presenting both the C16 and C17 of progesterone to the iron-oxy complex...
  77. ncbi Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats
    Srinivasan Dasarathy
    Gastroenterology Division, Department of Medicine, Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA
    J Hepatol 45:214-20. 2006
    ..We hypothesized that failure to gain body weight in the PCA rat was the consequence of low testosterone levels and will be reversed by 4-hydroxyandrostenedione, a specific aromatase inhibitor...
  78. ncbi Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3beta expression, while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation
    Valerie Wauthier
    Unité de Pharmacocinétique, Metabolisme, Nutrition, et Toxicologie PMNT, département des sciences pharmaceutiques, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Pharmacol 73:923-33. 2007
    ..These results indicate that while the induction of CYP2C12 during ageing could be due, at least partially, to the enhanced HNF3beta expression, the decline of CYP2C11 is unlikely related to a decrease of STAT5 activation...
  79. ncbi Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis
    Wei V Zhang
    Pharmacogenomics and Drug Development Group, Faculty of Pharmacy, University of Sydney, New South Wales, Australia
    J Pharmacol Exp Ther 322:770-7. 2007
    ..Lipid deposition in livers of patients with the metabolic syndrome may necessitate dosage adjustments for toxic drugs, including CLZ...
  80. ncbi Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively
    Xia Wen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Drug Metab Dispos 30:631-5. 2002
    ..In conclusion, trimethoprim and sulfamethoxazole can be used as selective inhibitors of CYP2C8 and CYP2C9 in in vitro studies. In humans, trimethoprim and sulfamethoxazole may inhibit the activities of CYP2C8 and CYP2C9, respectively...
  81. doi Ipriflavone pharmacokinetics in mutant Nagase analbuminemic rats
    Hye J Chung
    Center for Chemoinformatics, Life Sciences Research Division, Korea Institute of Science and Technology, Seoul, Republic of Korea
    Biopharm Drug Dispos 30:294-304. 2009
    ..0% decrease), possibly due to the increased intestinal CYP1A that resulted in increased intestinal metabolism and decreased gastrointestinal absorption of ipriflavone in NARs...
  82. pmc Purification and characterization of a vitamin D3 25-hydroxylase from pig liver microsomes
    E Axen
    Department of Pharmaceutical Biochemistry, University of Uppsala, Sweden
    Biochem J 287:725-31. 1992
    ..The results of the present study show that the pig appears to be a representative species for evaluation of vitamin D3 hydroxylases in other mammals, including man...
  83. ncbi The substrate binding site of human liver cytochrome P450 2C9: an NMR study
    S Poli-Scaife
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Biochemistry 36:12672-82. 1997
    ..Sulfaphenazole was easily included in that model; its very high affinity for CYP 2C9 is due to a third structural feature, the presence of its NH2 function which binds to CYP 2C9 iron...
  84. ncbi Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression
    J Blaisdell
    National Institutes of Environmental Health Sciences, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Drug Metab Dispos 26:278-83. 1998
    ..This unique polymorphism in the canine CYP2C subfamily may be a source of variability in the metabolic clearance in dogs of xenobiotics that are metabolized by the cytochrome P450 2C subfamily of enzymes...
  85. ncbi Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil
    G S Ratra
    Department of Toxicology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Toxicology 130:79-93. 1998
    ..Taken together, these data indicate that methapyrilene intoxication leads to mitochondrial disfunction and suggest a critical role for a loss of mitochondrial Ca2+ homeostasis in this model of hepatocyte death...
  86. pmc RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver
    P G Zaphiropoulos
    Department of Bioscience, Center for Nutrition and Toxicology, Karolinska Institute, Novum, 141 57 Huddinge, Sweden
    Nucleic Acids Res 27:2585-90. 1999
    ..However, these molecules could also be rationalized as being the products of trans splicing phenomena between distinct pre-mRNAs...
  87. ncbi Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    T S Klose
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biochem Mol Toxicol 13:289-95. 1999
    ..Although CYP2C8 has been shown to be phenobarbital inducible, neither a barbiturate-responsive regulatory sequence (a Barbie box) nor a phenobarbital-responsive enhancer module (PBREM) was found within the upstream region analyzed...
  88. ncbi Induction of xenobiotic metabolising enzymes in the common brushtail possum, Trichosurus vulpecula, by Eucalyptus terpenes
    G J Pass
    School of Pharmacy, University of Tasmania, Hobart, Australia
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:239-46. 1999
    ..It also confirms the importance of knowledge of diet when studying xenobiotic metabolising enzymes, particularly in wild animals such as the brushtail possum...
  89. ncbi Effect of dose on cyclosporine-induced suppression of hepatic cytochrome P450 3A2 and 2C11
    L J Brunner
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, 78712 1074, USA
    Eur J Pharm Biopharm 49:129-35. 2000
    ..Thus, the selective suppression of hepatic microsomal P450 by cyclosporine is not only dependent on the length of therapy, but also the dose administered...
  90. ncbi Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity
    D Schwarz
    Institute of Clinical Pharmacology, University Medical Centre Charité, Humboldt University of Berlin, Germany
    Pharmacogenetics 10:519-30. 2000
    ....
  91. pmc A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer
    G Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
    Environ Health Perspect 105:601-5. 1997
    ....
  92. ncbi Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation
    A M Butler
    Department of Medicine, University of Sydney, Westmead Hospital, Australia
    J Pharmacol Exp Ther 280:966-73. 1997
    ..In view of the role of this enzyme in the oxidation of many therapeutic agents, exposure to phosphorothioate pesticides may adversely affect drug elimination in humans...
  93. ncbi Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9
    P Jean
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Universite Paris V, France
    Eur J Biochem 241:797-804. 1996
    ..Experiments performed with human liver microsomes confirmed that tienilic acid 5-hydroxylase underwent a time-dependent inactivation (apparent t1/2 = 10 +/- 5 min) during 5-hydroxylation of tienilic acid...
  94. ncbi Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11
    C Pons
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universite Rene Descartes, Centre National de la Recherche Scientifique Unité de Recherche Associeé 400, Paris, France
    J Pharmacol Exp Ther 259:1328-34. 1991
    ....
  95. ncbi Metabolism of estradiol by human breast cancer
    Y J Abul-Hajj
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Minnesota, Minneapolis 55455
    Eur J Cancer Clin Oncol 24:1171-8. 1988
    ..The physiological role of these enzymes in the metabolism of estradiol in relation to breast cancer is discussed...
  96. pmc Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation
    N Harada
    Proc Natl Acad Sci U S A 82:2024-8. 1985
    ..Thus, the predominant expression of testosterone 16 alpha-hydroxylase in male 129/J mice is regulated pretranslationally, presumably at the transcriptional level of the P-450(16) alpha gene...
  97. ncbi Genetic regulation of hepatic steroid 16 alpha-hydroxylase activities in inbred strains of mice
    F Pasleau
    Endocrinology 115:1371-9. 1984
    ..Both hormonal and genetic regulations were responsible for the different phenotypes occurring in adult male and female C57Bl/6J and 129/J mouse livers...
  98. ncbi Monoclonal antibodies of differentiating specificities as probes of cytochrome P450h (2C11)
    D E Ryan
    Department of Protein Biochemistry, Hoffmann La Roche Inc, Nutley, New Jersey 07110
    Arch Biochem Biophys 301:282-93. 1993
    ....
  99. ncbi Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver
    A Strom
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    J Biol Chem 270:11276-81. 1995
    ..Our data indicate that the HPF1 elements in the rat CYP2C genes have limited functional importance and that HNF-4 is not a major trans-activator for any of these genes...
  100. ncbi Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9
    S Lecoeur
    Institut National de la Santé et de la Recherche Médicale U75, Centre Hospitalier Universitaire Necker Enfants Malades, Paris, France
    Mol Pharmacol 50:326-33. 1996
    ..Those data were compared with the results obtained in the current study with CYP2C9 in an attempt to elucidate one of the mechanisms by which CYP becomes immunogenic...
  101. ncbi Influence of partial hepatectomy in dogs on trimethadione metabolism and microsomal monooxygenases
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Xenobiotica 25:1301-10. 1995
    ..6. The data presented above do not reveal any relationship between P4502B11 induction and liver regeneration. The reason for such a change is unknown, therefore further investigation needs to be carried out...

Research Grants71

  1. CYTOCHROME P450--ENDOGENOUS SUBSTRATE METABOLISM
    David Waxman; Fiscal Year: 2002
    ..abstract_text> ..
  2. Cytochrome P450-Endogenous Substrate Metabolism
    David Waxman; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cytochrome P450-Endogenous Substrate Metabolism
    David Waxman; Fiscal Year: 2003
    ..abstract_text> ..
  4. STUDY OF OSTEOPOROTIC FRACTURES
    Jane Cauley; Fiscal Year: 2005
    ....
  5. 3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical Center
    Jane Cauley; Fiscal Year: 2010
    ..The SOF Coordinating Center was funded for 5 years;SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..
  6. Hip Strength Across the Menopausal Transition
    Jane Cauley; Fiscal Year: 2009
    ..Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women. ..
  7. 3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical Center
    Jane Cauley; Fiscal Year: 2009
    ..The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers. ..
  8. STUDY OF OSTEOPOROTIC FRACTURES
    Jane Cauley; Fiscal Year: 2007
    ..If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, Vitamin D supplementation, or medication, to promote high levels of function late in life. ..
  9. Estradiol, Cytokines & Bone Turnover--Effects on Fracture
    Jane Cauley; Fiscal Year: 2007
    ..Improved understanding of the biological mechanisms for these associations could lead to the development and testing of preventive intervention. ..
  10. Exogenous and Endogenous Biomarkers of CYP2D6 Variability in Pediatrics
    YVONNE SARAH LIN; Fiscal Year: 2010
    ..Ultimately, the goal of the research is to personalize the use of medications in children by selecting the appropriate dose of the correct medication for individual patients. ..
  11. REGULATING CEREBRAL MICROCIRCULATION BY ASTROCYTES
    DAVID RAE HARDER; Fiscal Year: 2010
    ..This knowledge will aid us in understanding, and hopefully preventing, a major cause of stroke. ..
  12. Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
    JAMES LEEDER; Fiscal Year: 2007
    ..abstract_text> ..
  13. REGULATING CEREBRAL MICROCIRCULATION BY ASTROCYTES
    David Harder; Fiscal Year: 2004
    ..Our investigations will provide vital new information defining mechanisms by which epoxygenase metabolites of astrocytes inhibit autoregulatory vasoconstriction of cerebral arteries. ..
  14. PLANT SPHINGOLIPIDS AND CARCINOGENESIS
    Dirck Dillehay; Fiscal Year: 2001
    ..These studies could lead to a better understanding of the relationships between diet and cancer through identification of glycosphingolipids as important constituents of food. ..
  15. AUTOREGULATION AND HYPOXIC DILATION IN THE BRAIN
    David Harder; Fiscal Year: 2002
    ..They will also determine if there is linkage between increased P450 w-hydroxylase activity in response to increasing transmural pressure and the cerebral vascular responses to changes in PO2. ..
  16. Hip Strength Across the Menopausal Transition
    Jane Cauley; Fiscal Year: 2007
    ..Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women. ..
  17. Modification of Vascular Signaling in the Brain by ROS
    David Harder; Fiscal Year: 2009
    ..We will determine how myogenic tone occurs and how it is regulated under normal and abnormal conditions to make sure there is enough blood flow to neurons so the brain can work properly. ..
  18. IMMUNOSUPPRESSANT MODULATION OF DRUG METABOLISM
    LANE BRUNNER; Fiscal Year: 2004
    ..This information will have direct application to transplant patients and give clinicians needed information regarding the relationship between immunosuppressive therapy and the prediction of toxicity. ..
  19. TRAINING IN THE EPIDEMIOLOGY OF AGING
    Jane Cauley; Fiscal Year: 2007
    ....