steroid 16 alpha hydroxylase

Summary

Summary: A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.

Top Publications

  1. ncbi Impact of transgene expression on drug metabolism following systemic adenoviral vector administration
    Shellie M Callahan
    College of Pharmacy, Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712 1074, USA
    J Gene Med 8:566-76. 2006
  2. ncbi Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat1
    S Bai
    4 Address correspondence to: Lane J. Brunner, Ph.D, Pharmaceutics Division, PHR 4.214E, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712-1074
    Transplantation 71:1585-92. 2001
  3. ncbi Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19
    K W Krausz
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg. 37, Bethesda, MD 20892, USA
    Drug Metab Dispos 29:1410-23. 2001
  4. ncbi Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans
    Ji Hong Shon
    Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, South Korea
    Pharmacogenetics 12:111-9. 2002
  5. ncbi Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship
    Thierry Cresteil
    Centre National de la Recherche Scientifique Unité Mixte Recherche 8532, Villejuif, France
    Drug Metab Dispos 30:438-45. 2002
  6. ncbi Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants
    Ieva Stupans
    Center for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, SA 5000, Australia
    J Agric Food Chem 50:2464-9. 2002
  7. ncbi Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes
    Nu He
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Eur J Clin Pharmacol 57:847-51. 2002
  8. ncbi Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
    L C McSorley
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK
    Biochem Pharmacol 60:517-26. 2000
  9. ncbi Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes
    Mitsuo Miyazawa
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
    Drug Metab Dispos 30:602-7. 2002
  10. ncbi The human CYP2C locus: a prototype for intergenic and exon repetition splicing events
    C Finta
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, SE 141 57, Sweden
    Genomics 63:433-8. 2000

Research Grants

Detail Information

Publications166 found, 100 shown here

  1. ncbi Impact of transgene expression on drug metabolism following systemic adenoviral vector administration
    Shellie M Callahan
    College of Pharmacy, Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712 1074, USA
    J Gene Med 8:566-76. 2006
    ..The objective of these studies was to determine how the transgene cassette influences CYP expression and function...
  2. ncbi Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat1
    S Bai
    4 Address correspondence to: Lane J. Brunner, Ph.D, Pharmaceutics Division, PHR 4.214E, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712-1074
    Transplantation 71:1585-92. 2001
    ..Nephrotoxicity caused by combination therapy is due to CsA elevating levels of SRL or by SRL itself. Concurrent administration of CsA and SRL in transplant patients should be performed with caution...
  3. ncbi Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19
    K W Krausz
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg. 37, Bethesda, MD 20892, USA
    Drug Metab Dispos 29:1410-23. 2001
    ..The mAb system offers large potential for studies of cytochrome P450 function useful in drug discovery and reduces the possibility of adverse drug reactions due to polymorphisms and drug interactions...
  4. ncbi Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans
    Ji Hong Shon
    Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, South Korea
    Pharmacogenetics 12:111-9. 2002
    ..The in-vivo contribution of CYP2C19 to tolbutamide 4-methylhydroxylation appears to be minor in humans. This suggests that, at least in vivo, tolbutamide remains a selective probe for measuring CYP2C9 activity in humans...
  5. ncbi Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship
    Thierry Cresteil
    Centre National de la Recherche Scientifique Unité Mixte Recherche 8532, Villejuif, France
    Drug Metab Dispos 30:438-45. 2002
    ....
  6. ncbi Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants
    Ieva Stupans
    Center for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, SA 5000, Australia
    J Agric Food Chem 50:2464-9. 2002
    ..It was also demonstrated that the presence of two phenolic groups is not always associated with antioxidant activity...
  7. ncbi Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes
    Nu He
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Eur J Clin Pharmacol 57:847-51. 2002
    ..To screen the inhibitory effects of H1-antihistamines on hepatic bufuralol 1'-hydroxylation and on tolbutamide 4-methylhydroxylation in human liver microsomes...
  8. ncbi Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
    L C McSorley
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK
    Biochem Pharmacol 60:517-26. 2000
    ....
  9. ncbi Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes
    Mitsuo Miyazawa
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
    Drug Metab Dispos 30:602-7. 2002
    ..Species-related differences exist in the oxidations of limonenes in CYP2B subfamily in rats and humans...
  10. ncbi The human CYP2C locus: a prototype for intergenic and exon repetition splicing events
    C Finta
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, SE 141 57, Sweden
    Genomics 63:433-8. 2000
    ..In addition, CYP2C8 gene expression was found to generate a variety of scrambled RNA molecules including species that contained repetitions of certain exons...
  11. ncbi Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation
    Jackie L Miller
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706 1102, USA
    Eur J Clin Pharmacol 58:69-72. 2002
    ..To determine whether the antiprotozoal drug atovaquone inhibits the cytochrome P(450) (CYP)2C9-mediated metabolism of sulphamethoxazole (SMX) to its potentially harmful hydroxylamine metabolite (SMX-HA) in vitro...
  12. ncbi In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11
    Jill S Warrington
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts New England Medical Center, Boston, MA 02111, USA
    Drug Metab Dispos 30:655-7. 2002
    ..P450 isoforms mediating sildenafil biotransformation differ substantially between humans and the male rat, thereby limiting the applicability of this species as a model for sildenafil metabolism and drug interactions in humans...
  13. ncbi Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack
    Nabil J Alkayed
    Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Stroke 33:1677-84. 2002
    ..We tested the hypothesis that experimental TIA induces expression of P450 2C11, an arachidonic acid epoxygenase that produces vasodilator epoxyeicosatrienoic acids, leading to increased tissue perfusion and reduced stroke damage...
  14. ncbi Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes
    Jun Sheng Wang
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290 Helsinki, Finland
    J Pharmacol Exp Ther 302:43-9. 2002
    ..The present findings suggest that the addition of Hsa and Hlc to microsomal incubation media may yield enzyme kinetic estimates more comparable with in vivo results...
  15. ncbi Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism
    Karthik Venkatakrishnan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    Biopharm Drug Dispos 23:183-90. 2002
    ..These factors should be considered when this formulation is used as an in vitro model in human liver microsomal drug metabolism studies...
  16. ncbi Prevention of latently expressed CYP2C11, CYP3A2, and growth hormone defects in neonatally monosodium glutamate-treated male rats by the N-methyl-D-aspartate receptor antagonist dizocilpine maleate
    Antje Kaufhold
    Laboratories of Biochemistry, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6048, USA
    J Pharmacol Exp Ther 302:490-6. 2002
    ..e., hypothalamic) damage produced at the time of MSG exposure. The irreversibility of the P450 damage is described as resulting from secondary defects initially induced by the neuronal lesions...
  17. ncbi Multiple mechanisms in indomethacin-induced impairment of hepatic cytochrome P450 enzymes in rats
    Yasuhiro Masubuchi
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Gastroenterology 122:774-83. 2002
    ..Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo...
  18. ncbi Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors
    M H Nelson
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, 8-101 WDH, 308 Harvard Street, Minneapolis, MN 55455, USA
    Epilepsy Res 44:71-82. 2001
    ..In light of typical SSRI blood levels observed in patients, this study also suggests that the risk of a SSRI-phenytoin interaction is highest with fluoxetine and norfluoxetine, and less likely with sertraline and paroxetine...
  19. ncbi Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily
    N T Ha-Duong
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, , 45, , 75270 Paris Cedex 06, France
    J Med Chem 44:3622-31. 2001
    ..Thus, compound 11 (R(1) = NH(2), R(2) = (CH(2))(2)CH(CH(3))(2)) appears to be particularly interesting for that purpose as its IC(50) value for CYP 2C8 is low (3 microM) and 20-fold smaller than those found for CYP 2C9 and 2C19...
  20. ncbi Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama)
    L Skalova
    Faculty of Pharmacy, Charles University, Heyrovskeho 1203, CZ 50005, Hradec Kralove, Czech Republic
    Chem Biol Interact 137:155-67. 2001
    ..The comparison of induction effect of ivermectin in rat, mouflon and fallow deer also demonstrates the inter-species differences in inducibility of CYP enzymes...
  21. ncbi Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations
    O V Olesen
    Department of Biological Psychiatry, Psychiatric University Hospital, Risskov, Denmark
    J Clin Pharmacol 41:823-32. 2001
    ..The rate of other metabolic routes mediated by CYP2D6 only corresponded to about one fifth of the CYP2D6 catalyzed N-demethylation rate...
  22. ncbi Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe
    N Matsunaga
    Department of Pharmaceutics, Kyoritsu College of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 24:1305-10. 2001
    ..It was also demonstrated that the qg and amount of CYP are useful parameters in the PKCYP-test by constructing a physiologically-based pharmacokinetic model which was applied to the PKCYP-test...
  23. ncbi Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Environ Mol Mutagen 38:329-38. 2001
    ..These S. typhimurium strains may be useful not only for predicting the metabolic activation of promutagens catalyzed by human CYP but also for identifying the CYP form involved...
  24. ncbi Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9
    Yoko Otake
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 30:103-5. 2002
    ..In addition, CYP1A1, although less efficient, was also able to oxidize the two flavonols. Thus, dietary flavonols are likely to undergo oxidative metabolism mainly in the liver but also extrahepatically...
  25. ncbi Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine
    G M Giancarlo
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Eur J Clin Pharmacol 57:31-6. 2001
    ..CONCLUSIONS: Formation of HPPH from PPH is mediated exclusively by CYP2C9 and 2C19, with CYP2C9 playing the major role...
  26. ncbi Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression
    Ravindra N Dhir
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104 6048, USA
    Drug Metab Dispos 30:141-7. 2002
    ..These changes in GRF-induced, sexually dimorphic secretory growth hormone profiles and the accompanying decline in P450 expression levels may anticipate similar, but more profound, changes to occur during senescence...
  27. ncbi In vitro cytochrome P450-mediated hepatic activities for five substrates in specific pathogen free chickens
    W F Khalil
    Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo183-8509, Japan
    J Vet Pharmacol Ther 24:343-8. 2001
    ..On the other hand, tolbutamide hydroxylation was markedly higher in chickens than in dogs...
  28. ncbi Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate
    Xue Qing Li
    Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca Research and Development, Molndal, Sweden
    J Pharmacol Exp Ther 300:399-407. 2002
    ..These data show that CYP2C8 is the main hepatic isoform responsible for the metabolism of AQ. The specificity, high affinity, and high turnover make AQ desethylation an excellent marker reaction for CYP2C8 activity...
  29. ncbi Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9
    C C Tsao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 40:1937-44. 2001
    ....
  30. ncbi Altered cytochrome P450 and P-glycoprotein levels in rats during simulated weightlessness
    Shirley K Lu
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, 78712 1074, USA
    Aviat Space Environ Med 73:112-8. 2002
    ....
  31. ncbi Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol
    Toshiro Niwa
    Division of Natural Science, Osaka Kyoiku University, Kashiwara, Japan
    Biol Pharm Bull 25:235-8. 2002
    ..These results suggest that nonylphenol inhibits human hepatic CYPs, especially CYP2C9 and CYP2C19, and steroidogenic CYP17 activities...
  32. ncbi Phosphonate O-deethylation of [4-(4-bromo-2-cyano-phenylcarbamoyl) benzyl]-phosphonic acid diethyl ester, a lipoprotein lipase-promoting agent, catalyzed by cytochrome P450 2C8 and 3A4 in human liver microsomes
    Yujiro Morioka
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Tokushima, Japan
    Drug Metab Dispos 30:301-6. 2002
    ..The selectivity of CYP2C8 in catalyzing phosphonate O-deethylation indicates that coadministration of drugs that are metabolized by the same enzyme requires careful consideration...
  33. ncbi P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage
    Eva Kaergel
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:273-9. 2002
    ..Because the products of AA epoxygenation have anti-inflammatory properties, this alteration may contribute to uncontrolled renal inflammation, which is a major cause of renal damage in dTGR...
  34. ncbi Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
    G Luo
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Arch Biochem Biophys 357:45-57. 1998
    ..CYP2C38 and CYP2C40 were found in liver, brain, kidney, and intestine, with trace amounts in lung and heart, while CYP2C37 and CYP2C39 appeared to be liver specific...
  35. pmc In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)
    X Wen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Br J Clin Pharmacol 52:547-53. 2001
    ..Co-administration of high doses of valproic acid with drugs that are primarily metabolized by CYP2C9 may result in significant drug interactions...
  36. ncbi Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2
    Christopher A Wiwi
    Division of Cell and Molecular Biology, Department of Biology Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 280:3259-68. 2005
    ....
  37. ncbi Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms
    R L Haining
    Department of Medicinal Chemistry, University of Washington, Seattle 98195, USA
    Arch Biochem Biophys 333:447-58. 1996
    ....
  38. ncbi Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
    Mehrdad Rahmaniyan
    Department of Medicine, Medical University of South Carolina, Strom Thurmond Research Building, Charleston, SC 29425, USA
    Am J Physiol Endocrinol Metab 288:E753-60. 2005
    ..It is concluded that CYP2C11 is a male-specific hepatic microsomal vitamin D 25-hydroxylase that hydroxylates vitamin D2, vitamin D3, 1alphaOHD2, and 1alphaOHD3. CYP2C11 is also a vitamin D 24-hydroxylase...
  39. ncbi Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver
    A Strom
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    Acta Endocrinol (Copenh) 118:314-20. 1988
    ..Northern blots showed that P-45016 alpha in the rat liver is pretranslationally regulated by the growth hormone secretory pattern. Southern blots indicated that few genes belong to the same P-450 gene family as P-45016 alpha...
  40. ncbi Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver
    A Strom
    Department of Medical Nutrition, Huddinge University Hospital, Sweden
    DNA Cell Biol 13:805-19. 1994
    ..To date, the two silencer elements and possibly also the HNF-1-like element are the only functional elements defined in the CYP2C11 gene, and it is conceivable that induction of the gene involves derepression of the silencer elements...
  41. pmc Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b
    N Ishida
    Rockefeller University Hospital, New York, NY 10021
    Nucleic Acids Res 17:6407. 1989
  42. ncbi Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 22:367-76. 2007
    ..Thus, CYP2C11/13 could associate with UGTs, but the affinity is assumed to be weaker than that of CYP2B/3As. These results suggest that there is isoform specificity in the interaction between P450s and UGTs...
  43. ncbi Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily
    N Ishida
    Suntory Institute for Biomedical Research, Osaka, Japan
    Biochem Biophys Res Commun 156:681-8. 1988
    ..2% and 99.0% similar in amino acid sequences, suggesting that they were virtually identical. CMF1a and CMF1b were different but 96.1% similar, and CMF3 was between 76% and 78% similar to other members of the rat P450IID family...
  44. ncbi Eight cytochrome P450s catalyze vitamin D metabolism
    Yoshihiko Ohyama
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Front Biosci 9:3007-18. 2004
    ..The main focus of this review is to summarize the properties of individual P450 in light of their catalytic activities to understand their physiological significance...
  45. ncbi Allelic and functional variability of cytochrome P4502C9
    C R Bhasker
    Department of Clinical Pharmacology, Flinders University of South Australia, Australia
    Pharmacogenetics 7:51-8. 1997
    ..It is likely that functional changes occurring as a result of the Ile359Leu transition are responsible for the tolbutamide poor metabolizer phenotype...
  46. ncbi Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation
    Susumu Imaoka
    Department of Chemical Biology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Cancer Lett 203:117-25. 2004
    ..These results suggest that active oxygen produced by P450 oxidized genomic DNA and induction of P450 increased oxidative stress that may contribute to tumor initiation and promotion...
  47. pmc Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats
    Ravindra N Dhir
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104 6048, USA
    Proc Natl Acad Sci U S A 100:15224-8. 2003
    ....
  48. ncbi Identification of the hepatic cytochrome P-450 isozymes induced and decreased by picloram
    G F Reidy
    National Occupational Health and Safety Commission, University of Sydney, NSW, Australia
    Biochem Pharmacol 37:1021-5. 1988
    ..Cytochrome P-450d is known to be a high spin haemoprotein...
  49. pmc cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates
    P G Zaphiropoulos
    Department of Medical Nutrition, Huddinge University Hospital, Sweden
    Proc Natl Acad Sci U S A 85:4214-7. 1988
    ..This relatively long period before P-450 15 beta and P-450 16 alpha mRNA induction is seen might indicate that protein factors mediating GH action are involved...
  50. ncbi Inflammation and sex hormone metabolism
    Martin Schmidt
    Institute of Biochemistry II, Hospital of the Friedrich Schiller University, 07740 Jena, Germany
    Ann N Y Acad Sci 1069:236-46. 2006
    ..The data discussed here suggest that therapy of RA patients may benefit from the use of nonaromatizable androgens and/or the use of aromatase inhibitors...
  51. ncbi Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17)
    Amanda C Swart
    Department of Biochemistry, University of Stellenbosch, South Africa Department of Reproductive and Developmental Sciences, University of Edinburgh Medical School, Scotland, UK
    Eur J Biochem 269:5608-16. 2002
    ..No 16alpha-hydroxylase and no lyase activity for 17alpha-hydroxyprogesterone. Sequence analyses showed that there are 28 different amino acid residues between human and baboon CYP17, primarily in helices F and G and the F-G loop...
  52. ncbi Marijuana extracts possess the effects like the endocrine disrupting chemicals
    Kazuhito Watanabe
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Toxicology 206:471-8. 2005
    ..01-1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana...
  53. pmc Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice
    Juan P Hernandez
    Biological Sciences, University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USA
    Toxicol Appl Pharmacol 216:186-96. 2006
    ..In conclusion, NP causes gender-specific P450 induction and therefore exposure to NP may cause distinct pharmacological and toxicological effects in males compared to females...
  54. ncbi Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction
    M J Melià
    Centre d Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Endocrinology 139:688-95. 1998
    ..These newly identified androgen-regulated genes will constitute very useful models for studying the nature of tissue-specific gene regulation by androgens...
  55. ncbi Increasing relevance of pharmacogenetics of drug metabolism in clinical practice
    P I Pillans
    Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Intern Med J 31:476-8. 2001
    ..It is important to be aware of which drugs are subject to pharmacogenetic variability. In the future, population-based pharmacogenetic testing will allow more individualized drug treatment and will avoid the current empiricism...
  56. ncbi Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat
    X Wang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Phytomedicine 17:203-11. 2010
    ..This study illustrated that the herb-drug interaction potential should be monitored by both in vitro and in vivo biotransformation/ pharmacokinetic parameters...
  57. ncbi Effects of huperzine A on liver cytochrome P-450 in rats
    Xiao Chao Ma
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Pharmacol Sin 24:831-5. 2003
    ..To predict possible drug interaction and assure safety medication of huperzine A (HupA)...
  58. ncbi Simultaneous HPLC determination of tolbutamide, phenacetin and their metabolites as markers of cytochromes 1A2 and 2C6/11 in rat liver perfusate
    Jan Jurica
    Department of Pharmacology, Faculty of Medicine, Masaryk University, Komenskeho nam 2, 662 43 Brno, Czech Republic
    J Pharm Biomed Anal 52:557-64. 2010
    ..6 and 11.4%, respectively. This method is applicable for the modeling and description of possible pharmacological interactions on rat cytochromes P450 1A2 and 2C6/11 or can be used for in vitro evaluation of both cytochromes 1A2 and 2C...
  59. ncbi Severe phenytoin intoxication in a subject homozygous for CYP2C9*3
    R Brandolese
    Rehabilitation Service, Conselve Hospital, ULSS 17, 35131 Padua, Italy
    Clin Pharmacol Ther 70:391-4. 2001
    ....
  60. ncbi Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity
    Mutsuko Hirata-Koizumi
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Drug Chem Toxicol 32:204-14. 2009
    ..5 mg/kg. These findings indicate that HDBB would have hepatic peroxisome proliferative activity, and the difference in susceptibility of male and female rats to this effect might lead to marked gender-related differences in HDBB toxicity...
  61. pmc Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population
    M G Scordo
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology at Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Br J Clin Pharmacol 52:447-50. 2001
    ..The distribution of variant CYP2C9 alleles was therefore investigated in an Italian and an Ethiopian population...
  62. ncbi Sex difference in the principal cytochrome P-450 for tributyltin metabolism in rats
    Shuji Ohhira
    Department of Hygiene, Dokkyo University School of Medicine, Mibu machi, Tochigi 321 0293, Japan
    Toxicol Appl Pharmacol 210:32-8. 2006
    ....
  63. ncbi Diazepam metabolism in the kidneys of male and female rats of various strains
    Hyung Sub Kim
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 72:7-11. 2010
    ..Our results suggested that there was a strain difference in CYP-dependent diazepam N-demethylation in the rat kidney, which is different from the finding in liver microsomes...
  64. ncbi The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats
    Chen Jiang Ying
    Department of Pharmacy, School of Pharmacy, Shujitsu University, Okayama, Japan
    Hypertens Res 31:1821-7. 2008
    ..01) and cerebral blood flow (p<0.0001). CYP2C11 plays an important role in regulating cerebral blood flow and, as a result, in preventing stroke in the salt-sensitive stroke-prone SHRSP/Izm...
  65. ncbi Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2
    Ryuji Kato
    Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Innate Immun 14:291-7. 2008
    ..Additionally, it is shown that their changes might reflect the recovery process from inflammation...
  66. ncbi Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures
    M Ringel
    Institute of Toxicology, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Xenobiotica 32:653-66. 2002
    ..However, a large interlaboratory variation is known. Our study provides evidence that differences in glucocorticoid concentration in the culture medium contribute to this variation...
  67. ncbi Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7
    Kiyoyuki Kitaichi
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20, Daikominami, Higashi ku, Nagoya 461 8673, Japan
    Biochem Pharmacol 67:1427-35. 2004
    ..coli O157 infection and that more than one cytokines induced by SLT-II, including nitric oxide, might make a critical contribution to the decrease of CYP content and its activity...
  68. ncbi Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats
    Konomu Saito
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18W9 North Ward, Sapporo 060 0818, Japan
    Drug Metab Dispos 32:959-65. 2004
    ..We found that both the rate of elimination of diazepam and the major metabolic pathways in diazepam metabolism differed among the different rat strains due to polymorphic expression of the two enzymes involved in diazepam metabolism...
  69. ncbi Differential effects of 2C9*3 and 2C9*2 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol
    Jose Hermida
    Hemostasis and Thrombosis Research Unit, School of Medicine, University of Navarra, Pamplona, Spain
    Blood 99:4237-9. 2002
    ..Because acenocoumarol sensitivity with the 2C9*2 variant does not seem to be clinically relevant, the drug could be an alternative to warfarin in 2C9*2 carriers...
  70. ncbi Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily
    Eduardo Barbosa-Sicard
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Biochem Biophys Res Commun 329:1275-81. 2005
    ..These results demonstrate that EPA is an efficient substrate of CYP2C enzymes and suggest that n-3 PUFA-rich diets may shift the CYP2C-dependent generation of physiologically active eicosanoids from AA- to EPA-derived metabolites...
  71. ncbi Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes
    Matthew A Cerny
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA
    Arch Biochem Biophys 436:265-75. 2005
    ....
  72. pmc Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes
    Haruki Higashimori
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Physiol Cell Physiol 299:C1068-78. 2010
    ....
  73. ncbi Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers
    Julia Kirchheiner
    Institute of Clinical Pharmacology, University Medical Center Charite, Humboldt University, Berlin, Germany
    Pharmacogenetics 12:101-9. 2002
    ..The pronounced differences in pharmacokinetics due to the amino acid variants did not significantly affect plasma insulin and glucose concentrations in healthy volunteers...
  74. ncbi Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase
    Gail D Anderson
    Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
    J Gend Specif Med 5:25-33. 2002
    ..However, genetics also controls the amount (or activity) of the enzymes. Sex-dependent differences have been demonstrated for several CYP isoenzymes and for UGT. Ethnicity also appears to play a role in the activity of these enzymes...
  75. ncbi The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme
    Stephanie Bechtel
    Universitat des Saarlandes, Saarbrucken, Germany Insitute of Biomedical Chemistry RAMS, Moscow, Russia
    Eur J Biochem 269:1118-27. 2002
    ..Thus, we present the first example of substrate recognition and conversion being attributed to the N-terminal part of human CYP11B2...
  76. ncbi Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age
    Kazuhiko Mori
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27701, USA
    Toxicol Pathol 35:242-51. 2007
    ..Alterations that are considered crucial to the interpretation of long-term study results could then be confirmed by subsequent metabolic studies...
  77. ncbi A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat
    Jeffrey J Iliff
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR 97239 3098, USA
    Exp Physiol 92:653-8. 2007
    ..The presence of enzymes involved in production and inactivation of EETs within extrinsic parasympathetic and sensory vasodilator fibres suggests a novel role for EETs in the neurogenic control of cerebral arteries...
  78. ncbi [Effects of ethyl acetate extract of Semen Hoveniae on liver microsomal cytochrome P450 isoenzyme in rat]
    Hong Zhang
    Department of Pharmacy, People s Hospital, Wuhan University, Wuhan 430060, China
    Zhongguo Zhong Yao Za Zhi 32:1917-21. 2007
    ..To investigate the effects of the ethyl acetate extract of Semen Hoveniae (ESH) on liver microsomal cytochrome P450 isoenzyme in rats...
  79. ncbi Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Drug Metab Dispos 31:833-6. 2003
    ..However, it appears that sulfaphenazole can be used as a selective inhibitor for rat CYP2C6. In addition, furafylline may also be a relatively selective inhibitor for rat CYP1A2...
  80. ncbi Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9
    X Wen
    Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu 4, FIN-00290 Helsinki, Finland
    Drug Metab Dispos 29:1359-61. 2001
    ..Gemfibrozil may also impair clearance of CYP2C19 and CYP1A2 substrates, but inhibition of other CYP isoforms is unlikely...
  81. ncbi Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver
    T Sueyoshi
    Pharmacogenetics, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 56:473-7. 1999
    ..Defaulting to this ERalpha-dependent mechanism results in localization of Stat5b to nuclei, which masculinizes the expression of Cyp genes in male mice...
  82. ncbi Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline
    G Gervasini
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Pharmacogenetics 11:29-37. 2001
    ..The possible clinical implications of this modulation are discussed...
  83. ncbi Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1
    K Inoue
    Osaka Prefectural Institute of Public Health, Japan
    Jpn J Hum Genet 39:337-43. 1994
    ..The results showed that three human CYP2C8, 2C9, and 2C10 cDNAs were located at the same subchromosomal region, 10q24.1...
  84. ncbi Homology modeling and substrate binding study of human CYP2C9 enzyme
    V A Payne
    Molecular Research Institute, Mountain View, California 94043 2316, USA
    Proteins 37:176-90. 1999
    ..Site-specific mutations are proposed for further integrated computational and experimental study...
  85. ncbi Sex differences at the initiation stage of rat liver carcinogenesis--influence of growth hormone
    D Liao
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Carcinogenesis 14:2045-9. 1993
    ..In conclusion, the present study demonstrates that sex differences occur at the initiation stage and that the secretory pattern of GH is responsible for the dimorphism in initiation with N-OH-AAF, but not with AFB1...
  86. ncbi Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid
    M P López-García
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Universite Rene Descartes, Paris, France
    Biochemistry 33:166-75. 1994
    ..This alkylation and inactivation of P450 2C9 (2C10) by TA could be a starting point for the appearance of anti-P450 2C antibodies detected in patients treated with TA and suffering from immunoallergic hepatitis...
  87. ncbi Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro
    E Stormer
    Humboldt University Berlin, Institute of Clinical Pharmacology, Germany
    Psychopharmacology (Berl) 151:312-20. 2000
    ..Perazine (PER) is a phenothiazine antipsychotic drug frequently used in Germany that undergoes extensive metabolism...
  88. pmc Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine
    P Damkier
    Institute of Public Health, Clinical Phamacology, University of Southern Denmark, Odense, Denmark
    Br J Clin Pharmacol 48:829-38. 1999
    ..To assess the possible use of this reaction as an in vivo marker of CYP3A4 activity, we studied the involvement of cytochromes CYP2C9, CYP2E1 and CYP3A4 in the in vivo oxidative metabolism of quinidine...
  89. ncbi Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18
    S M de Morais
    National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709
    Biochem Biophys Res Commun 194:194-201. 1993
    ..The availability of the sequences of the upstream regions and intron-exon junctions of CYP2C9 and CYP2C18 will allow future analysis of these genes in humans which differ in their ability to metabolize S-mephenytoin and other drugs...
  90. ncbi Comparison of human fetal hepatic and adrenal cytochrome P450 activities with some major gestational steroids and ethylmorphine as substrates
    A Rane
    Department of Clinical Pharmacology, Akademiska Hospital, Uppsala, Sweden
    J Steroid Biochem Mol Biol 43:335-41. 1992
    ..In adrenals, there was a correlation between the immunoidentified P450XVIIA1 bands and the 17 alpha-hydroxylation of progesterone...
  91. ncbi Interaction of drugs and Chinese herbs: pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica
    K Ishihara
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Pharm Pharmacol 52:1023-9. 2000
    ..It was concluded that administration of A. dahurica extract has the potential to interfere with the metabolism, by liver cytochrome P450, of other drugs...
  92. ncbi Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites
    S Rendic
    Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
    J Chromatogr B Biomed Sci Appl 735:73-83. 1999
    ..We suggest that the electronic effects of the 3-keto-4-ene structural moiety contribute to the selectivity within the active site of CYP3A4 enzyme resulting in selective 6beta-hydroxylation...
  93. ncbi A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24
    I C Gray
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, England
    Genomics 28:328-32. 1995
    ..The map also includes an adjacent gene, the serum retinol binding protein gene (RBP4). The incorporation of Généthon CA repeat genetic markers suggests the orientation of the loci to be Cen-RBP4-CYP2C18-CYP2C19-CYP2C9-CYP2C8-Tel ...
  94. ncbi Pretranslational up-regulation of the hepatic microsomal delta4-3-oxosteroid 5alpha-oxidoreductase in male rat liver by all-trans-retinoic acid
    M Murray
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Biochem Pharmacol 58:355-62. 1999
    ....
  95. pmc Frequency of cytochrome P450 2C9 mutant alleles in a Korean population
    Y R Yoon
    Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Korea
    Br J Clin Pharmacol 51:277-80. 2001
    ..To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations...
  96. ncbi Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1
    S Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Xenobiotica 30:1005-17. 2000
    ..7. The results thus indicate the involvement of rat CYP2C11/CYP2E1 and human CYP1A2 in the hepatic p-hydroxylation of o-phenylphenol...
  97. ncbi Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca(2+) changes and dilation in isolated resistance arteries
    S S Bolz
    Physiologisches Institut, Ludwig Maximilians Universitat, Munchen, Germany
    FASEB J 14:255-60. 2000
    ..Bolz, S.-S., Fisslthaler, B., Pieperhoff, S., de Wit, C., Fleming, I., Busse, R., Pohl, U. Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca(2+) changes and dilation in isolated resistance arteries...
  98. ncbi Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol
    A F Badawi
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Metabolism 50:1001-3. 2001
    ....
  99. ncbi Pharmacogenetics of warfarin elimination and its clinical implications
    H Takahashi
    Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Clin Pharmacokinet 40:587-603. 2001
    ..However, relationships between CYP2C9 genotype, enzyme activity, metabolism of probe substrates, dosage requirements and bleeding complications should be interpreted with caution, and further studies are required...
  100. ncbi Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes
    Y Masubuchi
    Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Pharmacol Exp Ther 282:1435-41. 1997
    ....
  101. ncbi Hepatic microsomal enzyme activity in the koala and tammar wallaby: high 17beta-hydroxysteroid oxidoreductase activity in koala liver microsomes
    I Stupans
    Center for Pharmaceutical Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 123:67-73. 1999
    ..From detailed kinetic studies menthone was found to be an uncompetitive inhibitor of the activity in koala liver (Ki 220 microM)...

Research Grants11

  1. STEROID METABOLISM AND ACTION IN CANCER
    Mortimer Levitz; Fiscal Year: 1993
    ..All patients in the study are entered in a computer memory bank so that the subsequent course of fibrocystic disease may be assessed in terms of the laboratory findings...
  2. EFFECT OF MAMMARY TUMORS ON STEROID METABOLISM
    YUSUF ABUL HAJJ; Fiscal Year: 1980
    ..The effect of surgical removal of tumor and cell-free tumor extract administration will be studied in order to determine whether the tumor contains a factor(s) responsible for altered steroid metabolism...
  3. PATHOGENESIS OF ANTICONVULSANT HYPERSENSITIVITY SYNDROME
    JAMES LEEDER; Fiscal Year: 2003
    ..It is anticipated that the basic experimental paradigm employed for these studies can also be applied to other idiosyncratic toxicities with suspected drug bioactivation and immune etiologies. ..
  4. Outcomes of Sleep Disorders in Older Men - Pittsburgh
    Jane Cauley; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. [unreadable] [unreadable]..
  5. Estradiol, Cytokines & Bone Turnover--Effects on Fracture
    Jane Cauley; Fiscal Year: 2007
    ..Improved understanding of the biological mechanisms for these associations could lead to the development and testing of preventive intervention. ..
  6. Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
    JAMES LEEDER; Fiscal Year: 2007
    ..abstract_text> ..
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Jane Cauley; Fiscal Year: 2005
    ....
  8. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2008
    ..abstract_text> ..
  9. AUTOREGULATION AND HYPOXIC DILATION IN THE BRAIN
    David Harder; Fiscal Year: 2002
    ..They will also determine if there is linkage between increased P450 w-hydroxylase activity in response to increasing transmural pressure and the cerebral vascular responses to changes in PO2. ..
  10. PLANT SPHINGOLIPIDS AND CARCINOGENESIS
    Dirck Dillehay; Fiscal Year: 2001
    ..These studies could lead to a better understanding of the relationships between diet and cancer through identification of glycosphingolipids as important constituents of food. ..
  11. IMMUNOSUPPRESSANT MODULATION OF DRUG METABOLISM
    LANE BRUNNER; Fiscal Year: 2004
    ..This information will have direct application to transplant patients and give clinicians needed information regarding the relationship between immunosuppressive therapy and the prediction of toxicity. ..