steroid hydroxylases

Summary

Summary: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.

Top Publications

  1. ncbi Vitamin D: more than a "bone-a-fide" hormone
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Endocrinol 17:777-91. 2003
  2. ncbi Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
    Binbin Wang
    Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Lett 369:104-7. 2004
  3. ncbi Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
  4. pmc Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
    Kiwon Park
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Leukoc Biol 88:1081-7. 2010
  5. pmc Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions
    Nair Lopes
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
    BMC Cancer 10:483. 2010
  6. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
  7. pmc Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
    Ulf Diczfalusy
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Lipid Res 50:2258-64. 2009
  8. ncbi Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    Y Ikeda
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    Mol Endocrinol 8:654-62. 1994
  9. doi CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
    J Steroid Biochem Mol Biol 121:254-6. 2010
  10. pmc Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    Rebecca Schule
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Lipid Res 51:819-23. 2010

Research Grants

  1. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2001
  2. STEROIDOGENIC P450 ENZYMES--STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 1999
  3. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 1999
  4. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2002
  5. STEROIDOGENIC P450 ENZYMES--STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 2000
  6. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2000
  7. REGULATION OF CYTOCHROME P450'S IN ADRENAL
    VIRGINIA BLACK; Fiscal Year: 1990
  8. STEROIDOGENIC P450 ENZYMES: STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 1993
  9. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2000
  10. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2001

Detail Information

Publications231 found, 100 shown here

  1. ncbi Vitamin D: more than a "bone-a-fide" hormone
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Endocrinol 17:777-91. 2003
    ....
  2. ncbi Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
    Binbin Wang
    Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Lett 369:104-7. 2004
    ..32, P < 0.001). Our data reveal that the polymorphism of CYP46 intron 2 is implicated in the susceptibility to LOAD and a strong synergistic interaction between CYP46 TT homozoygots and APOE epsilon4 carrier status on the risk of LOAD...
  3. ncbi Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
    ..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
  4. pmc Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
    Kiwon Park
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Leukoc Biol 88:1081-7. 2010
    ....
  5. pmc Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions
    Nair Lopes
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
    BMC Cancer 10:483. 2010
    ..We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions...
  6. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
    ..The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system...
  7. pmc Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
    Ulf Diczfalusy
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Lipid Res 50:2258-64. 2009
    ..The possibility is discussed that 25-hydroxycholesterol may have a role in the inflammatory response, in addition to its more established role in the regulation of cholesterol homeostasis...
  8. ncbi Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    Y Ikeda
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    Mol Endocrinol 8:654-62. 1994
    ..studied the developmental profile of steroidogenic factor-1 (SF-1), a nuclear receptor that regulates the steroid hydroxylases. SF-1 transcripts first appear on embryonic day 9 (E9) in the urogenital ridge, the probable source of ..
  9. doi CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24
    Rene St-Arnaud
    Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
    J Steroid Biochem Mol Biol 121:254-6. 2010
    ....
  10. pmc Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    Rebecca Schule
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Lipid Res 51:819-23. 2010
    ..If the accumulation of 27-hydroxycholesterol is an important pathogenetic factor, a reduction of its levels may reduce or prevent the neurological symptoms. A possible strategy to achieve this is discussed...
  11. ncbi Disruption of the oxysterol 7alpha-hydroxylase gene in mice
    J Li-Hawkins
    Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 275:16536-42. 2000
    ..A failure to catabolize oxysterols in the male kidney may lead to a decrease in de novo sterol synthesis...
  12. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  13. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  14. ncbi Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes
    Lionel Drocourt
    INSERM U128, Institut Federatif de Recherche 24, CNRS, 1919 Route de Mende, 34293 Montpellier, Cedex 05, France
    J Biol Chem 277:25125-32. 2002
    ..In conclusion, this work suggests that VDR, PXR, and CAR control the basal and inducible expression of several CYP genes through competitive interaction with the same battery of responsive elements...
  15. ncbi 25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer
    Eduardo Carneiro de Lyra
    Instituto Brasileiro de Controle do Cancer, Av Alcântara Machado 2576, São Paulo SP CEP 03102 002, Brazil
    J Steroid Biochem Mol Biol 100:184-92. 2006
    ..A low 1,25(OH)2D3 serum concentration seems to be associated to breast cancer, however, the mechanism involved in this regulation is still unclear...
  16. doi 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    J Steroid Biochem Mol Biol 118:162-70. 2010
    ..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
  17. ncbi Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation
    Sheng Chen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1634-47. 2007
    ..These results indicate that 1,25(OH)(2)D(3) may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders...
  18. ncbi Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob mice
    Ayako Matsunuma
    Department of Biochemistry, Ohu University School of Dentistry, Koriyama 963 8611, Japan
    Endocrinology 145:1367-75. 2004
    ..Therefore, low BMD in leptin-deficient mice appears to be related to stimulation of bone resorption by 1,25-(OH)(2)D(3)...
  19. pmc CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions
    Ashlee R Stiles
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:28485-9. 2009
    ..The role of CYP7B1 in brain is under investigation; recent studies show that spastic paraplegia type 5, a progressive neuropathy, is caused by loss-of-function mutations in the human gene...
  20. ncbi Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells
    Maya Khorchide
    Department of Pathophysiology, Medical University of Vienna, A 1090 Vienna, Waehringerguertel 18 20, Austria
    J Steroid Biochem Mol Biol 93:167-72. 2005
    ..This demonstrates for the first time that synthesis of 1,25-dihydroxycholecalciferol in human prostate tumors could be reinitiated by epigenetic regulators...
  21. pmc Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis
    K Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Mult Scler 16:133-8. 2010
    ..The finding of a marginally significant gene-environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context...
  22. doi Dysregulation of renal vitamin D metabolism in the uremic rat
    Christian F Helvig
    Department of Research and Development, Cytochroma Inc, 330 Cochrane Drive, Markham, Ontario, Canada
    Kidney Int 78:463-72. 2010
    ..Thus, our findings suggest that dysregulation of CYP24 may be a significant mechanism contributing to vitamin D insufficiency and resistance to vitamin D therapy in CKD...
  23. pmc Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009
    ..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results...
  24. pmc Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:7711-5. 2004
    ..These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency...
  25. ncbi New insights into the mechanisms of vitamin D action
    Sylvia Christakos
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Cell Biochem 88:695-705. 2003
    ..Thus in recent years a number of exciting discoveries have been made that have enhanced our understanding of mechanisms involved in the pleiotropic actions of 1,25(OH)(2)D(3)...
  26. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    ....
  27. pmc Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  28. ncbi Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels
    Cynthia Fourgeux
    Eye and Nutrition Research Group, UMR1129 FLAVIC Flaveur, vision et comportement du consommateur Flavor, Vision, and Consumer Behavior, INRA French National Institute for Agricultural Research, Dijon, France
    Invest Ophthalmol Vis Sci 50:5712-7. 2009
    ....
  29. ncbi Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes
    Tara I Ellison
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 282:10953-62. 2007
    ..Cumulatively, these studies support the concept that transactivation by VDR in keratinocytes may be uncoupled from the 1,25(OH)2D3 ligand...
  30. pmc Brain cholesterol turnover required for geranylgeraniol production and learning in mice
    Tiina J Kotti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3869-74. 2006
    ..We conclude that cholesterol turnover in brain activates the mevalonate pathway and that a constant production of geranylgeraniol in a small subset of neurons is required for LTP and learning...
  31. ncbi The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
    Frederic Gachon
    Department of Molecular Biology, National Center of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 1211 Geneva 4, Switzerland
    Cell Metab 4:25-36. 2006
    ..Indeed, PAR bZip triple knockout mice are hypersensitive to xenobiotic compounds, and the deficiency in detoxification may contribute to their early aging...
  32. ncbi Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer
    Marjorie L McCullough
    Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA
    Annu Rev Nutr 29:111-32. 2009
    ..Currently, there is no strong, consistent epidemiologic evidence for substantial influences of single variants in vitamin D pathway genes on risk for colorectal, breast, or prostate cancer, but promising leads are developing...
  33. ncbi Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    I Bjorkhem
    Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Sweden
    J Lipid Res 39:1594-600. 1998
    ..The possibility is discussed that circulating levels of 24S-hydroxycholesterol can be used as a marker for pathological and/or developmental changes in the brain...
  34. doi 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells
    Guido Heine
    Allergy Center Charité, CCM, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Immunol 38:2210-8. 2008
    ....
  35. ncbi 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
    Yan Ru Lou
    Department of Anatomy, Medical School, FIN 33014, University of Tampere, Finland
    FASEB J 18:332-4. 2004
    ..Altogether our results suggest that 25OHD3 at a high but physiological concentration acts as an active hormone with respect to vitamin D3 responsive gene regulation and suppression of cell proliferation...
  36. pmc Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
    Denise M O Ramirez
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 507:1676-93. 2008
    ..These findings reveal the microsomal localization of 24-hydroxylase and provide subcellular insight into cholesterol turnover in the brain...
  37. ncbi Selective inhibition of vitamin D hydroxylases in human keratinocytes
    I Schuster
    Novartis Research Institute, Vienna, Austria
    Steroids 66:409-22. 2001
    ..Besides their use as valuable tools in elucidating regulatory mechanisms, inhibitors of VD hydroxylases may give rise to novel therapeutic strategies, especially in defects of cell growth and differentiation...
  38. pmc A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:15599-610. 2010
    ..We conclude that a more complex mechanism is responsible for the striking CYP24A1 up-regulation induced by the vitamin D hormone in target cells...
  39. pmc Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
    ..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
  40. pmc Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer
    Wei Luo
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 70:5953-62. 2010
    ..Our findings indicate that repression of CYP24A1 gene expression in human prostate cancer cells is mediated in part by promoter DNA methylation and repressive histone modifications...
  41. ncbi Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  42. ncbi Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine
    Catherine Theodoropoulos
    Departement de Pharmacologie, Faculte de Medecine, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 58:489-99. 2003
    ..Total RNA was extracted and cDNA synthesized by RT-PCR. The cDNA obtained was amplified by radioactive PCR, the signal intensity evaluated by densitometric analyses and expressed in relation to the levels of GAPDH...
  43. pmc Cholesterol 25-hydroxylation activity of CYP3A
    Akira Honda
    Department of Gastroenterology, Center for Collaborative Research, Ibaraki 300 0395, Japan
    J Lipid Res 52:1509-16. 2011
    ..650, P < 0.0001, n = 78), but did not significantly correlate with the levels of 27-hydroxycholesterol or 24S-hydroxycholesterol. These results demonstrate the significance of CYP3A on the production of 25-hydroxycholesterol...
  44. ncbi QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells
    Sujatha Sundaram
    Department of Surgery, Dartmouth Medical School, One Medical Center Drive, HB 7850, Lebanon, NH 03756, USA
    Mol Cancer Ther 5:2806-14. 2006
    ..QW also blocked the sustained induction of CYP24 expression by 1,25(OH)(2)D(3) and EB 1089, increased the potency of 1,25(OH)(2)D(3) and EB 1089, and inhibited breast tumor cell proliferation and invasion...
  45. doi Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: breaking paradigms
    Lorenza Díaz
    Departamento de Biologia de la Reproduccion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico DF, Mexico
    Cytokine 55:188-94. 2011
    ..Altogether, our results offer new insights into the mechanisms whereby PRL is regulated in immune cells...
  46. ncbi CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines
    John Dulos
    University Medical Center Utrecht, The Netherlands
    Arthritis Rheum 52:770-8. 2005
    ..The purpose of this study was to investigate the presence of 7alpha-OH-DHEA in synovial samples and the cytokine regulation of CYP7B activity in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
  47. pmc The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis
    Henrik C Horváth
    Department of Medicine, Semmelweis University, Budapest, Hungary
    J Histochem Cytochem 58:277-85. 2010
    ..A parallel increased expression of the proliferation marker Ki-67 in the same samples suggests that overexpression of CYP24A1 reduced local 1,25-D(3) availability, decreasing its antiproliferative effect...
  48. pmc The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells
    Juha M Matilainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 285:24174-83. 2010
    ..In conclusion, our data suggest that in comparison to normal cells, clearing of 1alpha,25(OH)(2)D(3) is enhanced in malignant cells due to differences in transcriptional regulation of CYP24 and metabolism of CYP24 mRNA...
  49. doi Vitamin D analogues targeting CYP24 in chronic kidney disease
    Gary H Posner
    Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Steroid Biochem Mol Biol 121:13-9. 2010
    ..Studies with both new analogues underscore the potential utility of CYP24 inhibition in the treatment of secondary hyperparathyroidism in CKD...
  50. ncbi Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats
    Fumi Takemoto
    Kidney Center, Toranomon Hospital, Tokyo, Japan
    Kidney Int 64:414-20. 2003
    ....
  51. doi Influence of 1,25-dihydroxy vitamin D3 on TLR4-induced activation of antigen presenting cells is dependent on the order of receptor engagement
    Vandana Gambhir
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    Immunobiology 216:988-96. 2011
    ..Consequently, engagement of VDR by 1,25-(OH)₂D₃ can partially interfere with TLR-4-L-induced activation of pAPCs only when it occurs before TLR-4 stimulation...
  52. pmc Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women
    Tsogzolmaa Dorjgochoo
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 20:2313-6. 2011
    ..Previous studies evaluating the association of vitamin D-related genetic variants with breast cancer risk have produced inconsistent results...
  53. ncbi No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 89:163-6. 2004
    ..Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM...
  54. pmc CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma
    Guoan Chen
    Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:817-26. 2011
    ..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells...
  55. ncbi Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 350:65-77. 2005
    ....
  56. ncbi CYP46: a risk factor for Alzheimer's disease or a coincidence?
    Ewa Golanska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Neurosci Lett 383:105-8. 2005
    ..However, considering the extreme divergence of results obtained by different authors, a clear connection between the CYP46 gene and AD is questionable...
  57. ncbi Genetic association of CYP46 and risk for Alzheimer's disease
    Onofre Combarros
    Neurology Service, Marqués de Valdecilla University Hospital University of Cantabria, Santander, Spain
    Dement Geriatr Cogn Disord 18:257-60. 2004
    ..Our results indicate that the intron 2 CYP46 C/C genotype may predispose to AD, and this association is independent of the apolipoprotein E genotype...
  58. ncbi Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
    Valentina Fernández Del Pozo
    Servicio de Neurologia, Hospital Cruces, Barakaldo, Spain
    Dement Geriatr Cogn Disord 21:81-7. 2006
    ....
  59. ncbi Cyp46 polymorphisms in Alzheimer's disease: a review
    Anália Nusya Medeiros Garcia
    Instituto de Ciencias Biologicas, UPE, Recife, Brazil
    J Mol Neurosci 39:342-5. 2009
    ..The aim of this review is to describe and summarize the findings of the researches about the relationship between CYP46 and AD that have been published in the past 9 years...
  60. ncbi Oxysterol biosynthetic enzymes
    D W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9046, USA
    Biochim Biophys Acta 1529:126-35. 2000
    ..This article focuses on the properties of these enzymes...
  61. ncbi Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
    Lionel Bretillon
    Eye and Nutrition Research Group, UMR 1129 FLAVIC, INRA, ENESAD, University of Burgundy, Dijon, France, and Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Eye Res 32:361-6. 2007
    ....
  62. pmc CYP24A1 inhibition enhances the antitumor activity of calcitriol
    Josephia R Muindi
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Endocrinology 151:4301-12. 2010
    ....
  63. pmc 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Breast Cancer Res 7:R980-6. 2005
    ..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...
  64. ncbi Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    Kristin K Deeb
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Nat Rev Cancer 7:684-700. 2007
    ..Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents...
  65. ncbi Expression of VDR and CYP24A1 mRNA in human tumors
    Mark G Anderson
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Cancer Chemother Pharmacol 57:234-40. 2006
    ..These data suggest that the VDR signaling pathway may be compromised via the modulation of CYP24A1 and VDR in human tumors...
  66. ncbi TNF-alpha interferes with lipid homeostasis and activates acute and proatherogenic processes
    Klementina Fon Tacer
    Center for Functional Genomics and Biochips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
    Physiol Genomics 31:216-27. 2007
    ..Observed acute alterations in lipid metabolism are in agreement with chronic disturbances found in patients...
  67. doi Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis
    Li Laine Ooi
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 70:1835-44. 2010
    ..These effects are partly mediated through secondary changes in the bone microenvironment, along with direct effects of vitamin D on tumor growth...
  68. ncbi Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients
    Y Li
    Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:399-404. 2006
    ..Genetic association of CYP46A1 polymorphisms with AD had been under extensive investigations; however, observations on intron 2 T-->C (rs754203) generated inconclusive results...
  69. pmc Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
    Matthias Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
    Respir Res 7:60. 2006
    ....
  70. ncbi Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
    Jillian Ross
    CXR Biosciences Ltd, 2 James Lindsay Place, Dundee DD1 5JJ, UK
    Toxicol Sci 116:452-66. 2010
    ..However, all parameters investigated to date suggest that much of their functionality is maintained...
  71. ncbi In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg Germany
    Cancer Biol Ther 6:48-55. 2007
    ....
  72. ncbi RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells
    P H Anderson
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 103:601-5. 2007
    ....
  73. pmc Vitamin D metabolism and action in human bone marrow stromal cells
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Endocrinology 151:14-22. 2010
    ....
  74. ncbi Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements
    K S Chen
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    Biochim Biophys Acta 1263:1-9. 1995
    ..Further characterization of these VDREs in various constructs with either a native or TK promoter suggests that both VDREs are required for the optimal induction of 24-hydroxylase expression by 1,25-(OH)2D3...
  75. ncbi Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators
    Barbara Borroni
    Neurologic Clinic, University of Brescia, Spedali Civili de Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy
    Neurobiol Aging 25:747-51. 2004
    ..02). These findings provide direct evidence that CYP46 and ApoE polymorphisms synergically increase the risk for AD development, and influence on the rate of cognitive decline...
  76. ncbi Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
    D G Albertson
    1 Cancer Research Institute, University of California, San Francisco, Box 0808, San Francisco, California, USA
    Nat Genet 25:144-6. 2000
    ..The putative oncogene ZNF217 (ref. 5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other...
  77. ncbi Development of a vitamin D-responsive organ culture system for adult and old rat intestine
    H J Armbrecht
    Geriatric Research, Education, and Clinical Center, St Louis VA Medical Center, St Louis, Missouri 63125, USA
    Dig Dis Sci 47:2831-8. 2002
    ..Since the 24-hydroxylase is the first step in the degradative pathway for 1,25(OH)2D in the intestine, increased duodenal expression of the 24-hydroxylase may contribute to the decreased action of 1,25(OH)2D on the adult duodenum...
  78. ncbi Steroid and sterol 7-hydroxylation: ancient pathways
    Richard Lathe
    Division of Biomedical Sciences, University of Edinburgh, George Square, EH9 9XD, Edinburgh, UK
    Steroids 67:967-77. 2002
    ..Early receptor targets probably included intracellular sterol sites, some modern steroids may continue to act at these targets. 7-Hydroxylation of DHEA may reflect conservation of an early signaling pathway...
  79. ncbi Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  80. ncbi Autocrine metabolism of vitamin D in normal and malignant breast tissue
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham, Birmingham, United Kingdom
    Clin Cancer Res 11:3579-86. 2005
    ..The aim of this study was to investigate the significance of this in breast cancer...
  81. ncbi Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta
    John Dulos
    Organon NV, Oss, The Netherlands
    Arthritis Rheum 50:3346-53. 2004
    ..This study was undertaken to investigate the putative role of CYP7B in arthritis using murine collagen-induced arthritis (CIA), an interleukin-1beta (IL-1beta)-dependent model...
  82. ncbi Gene regulatory potential of nonsteroidal vitamin D receptor ligands
    MIKAEL PERAKYLA
    Department of Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Endocrinol 19:2060-73. 2005
    ..At a noncalcemic dose of 150 microg/kg, CD4528 showed in vivo a clear induction of CYP24 expression and therefore may be used as a lead compound for the development of therapeutics against psoriasis, osteoporosis, and cancer...
  83. ncbi 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin
    X Y Li
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Endocrinol 13:1686-94. 1999
    ..D3 exerts dual positive influences on its nuclear receptor, simultaneously stimulating VDR transactivation activity and retarding VDR degradation...
  84. ncbi Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    Z Wu
    Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, P O Box 95, Rootstown, OH 44272, USA
    J Lipid Res 40:2195-203. 1999
    ..Transient transfection assays of CYP7B1 promoter/luciferase reporter constructs in HepG2 cells revealed that the promoter was highly active. The 5' upstream region from nt -83 to +189 is the core promoter of the gene...
  85. ncbi Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression
    R Ahlgren
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 265:3313-9. 1990
    ..Whether or not there are sequences conferring cAMP responsiveness which are common both to P-450scc and the other steroidogenic P-450 genes remains to be established...
  86. ncbi Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction
    P P Dwivedi
    Department of Biochemistry, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 275:47-55. 2000
    ..A fundamental role was established for transcriptional cooperation between Ras-activated Ets proteins and the VDR.RXR complex in mediating 1, 25-(OH)(2)D(3) action on the CYP24 promoter...
  87. ncbi Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:367-73. 2004
    ..The possible mitogenic effects of vitamin D should be considered when evaluating treatment of ovarian cancer with vitamin D...
  88. ncbi Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon
    Damien Matusiak
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street M C 716, Chicago, IL 60612, USA
    Cancer Epidemiol Biomarkers Prev 14:2370-6. 2005
    ..Overall, these data support using 25(OH)D3 for colorectal cancer chemoprevention but suggest that pro-vitamin D is less likely to be useful for colorectal cancer chemotherapy...
  89. doi Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b
    Sayaka Komagata
    Drug Metabolism and Toxicology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Mol Pharmacol 76:702-9. 2009
    ..In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24, which serves as a possible mechanism for the high CYP24 expression in cancer tissues...
  90. ncbi Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, California 94305 5118, USA
    J Urol 168:1583-8. 2002
    ..We tested the growth inhibitory activity of ketoconazole combined with 1,25-dihydroxyvitamin D3 (calcitriol) and with the vitamin D analogue EB 1089 in a preclinical model of prostate cancer...
  91. ncbi Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Biol Reprod 75:816-22. 2006
    ....
  92. ncbi Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis
    C M Hansen
    Department of Biochemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    Front Biosci 6:D820-48. 2001
    ..The present review will focus on the results obtained in these studies and describe some of the synthetic analogs, which have shown to be of particular interest in relation to cancer...
  93. ncbi Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts
    Euclides Avila
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico D F, Mexico
    J Steroid Biochem Mol Biol 103:90-6. 2007
    ..The overall data suggest that calcitriol downregulates CYP27B1 expression via a cAMP-dependent signaling pathway, whereas upregulates 24-hydroxylase gene expression through a VDR-dependent mechanism...
  94. ncbi 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression
    P Bareis
    Department of Pathophysiology, University of Vienna Medical School, Vienna, A-1090, Austria
    Biochem Biophys Res Commun 285:1012-7. 2001
    ....
  95. ncbi 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes
    Yohan Bosse
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 29:161-8. 2007
    ..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
  96. ncbi Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
    Ivy Chung
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:8704-14. 2007
    ....
  97. ncbi Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  98. ncbi Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene
    Katsuhisa Tashiro
    Molecular Biology Laboratory, Department of Life and Environmental Sciences, Prefectural University of Hiroshima, 562 Nanatsuka, Shobara, Hiroshima 727 0023, Japan
    Biochem Biophys Res Commun 358:259-65. 2007
    ..Further upstream sequence and the 5'-untranslated region did not appear to play a major role in the vitamin D response...
  99. ncbi CYP27A1 and CYP24 expression as a function of malignant transformation in the colon
    Damien Matusiak
    Department of Medicine, University of Illinois at Chicago, 840 S Wood St M C 716, Chicago, IL 60612, USA
    J Histochem Cytochem 55:1257-64. 2007
    ..These data indicate that non-toxic vitamin D precursors should be sufficient for CRC chemoprevention, but that neither vitamin D nor its precursors may be sufficient for CRC chemotherapy...
  100. pmc Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2
    Min Cui
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47906 2059, USA
    J Cell Physiol 219:132-42. 2009
    ..Our data show that there are both promoter-specific and cell stage-specific roles for the ERK signaling pathway on 1,25(OH)(2)D(3)-mediated gene induction in enterocyte-like Caco-2 cells...
  101. ncbi 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis
    H S Cross
    Department of Pathophysiology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Steroids 66:287-92. 2001
    ....

Research Grants141 found, 100 shown here

  1. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2001
    ..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
  2. STEROIDOGENIC P450 ENZYMES--STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 1999
    ..This competitive renewal focuses primarily on two steroid hydroxylases, the mitochondrial cholesterol side chain cleavage cytochrome P450 (P450scc) and the microsomal 17alpha-..
  3. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 1999
    ..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
  4. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2002
    ..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
  5. STEROIDOGENIC P450 ENZYMES--STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 2000
    ..This competitive renewal focuses primarily on two steroid hydroxylases, the mitochondrial cholesterol side chain cleavage cytochrome P450 (P450scc) and the microsomal 17alpha-..
  6. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2000
    ..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
  7. REGULATION OF CYTOCHROME P450'S IN ADRENAL
    VIRGINIA BLACK; Fiscal Year: 1990
    ..This 52K protein does not react with antibodies against known adrenal microsomal steroid hydroxylases (P45021 and P45017alpha), but does react with antibody against methylcholanthrene-induced P450s in rat ..
  8. STEROIDOGENIC P450 ENZYMES: STRUCTURAL MUTAGENESIS
    Michael Waterman; Fiscal Year: 1993
    ..Like most forms of P450 involved in endogenous substrate metabolism, these steroid hydroxylases demonstrate a high degree of substrate specificity both with respect to the steroids which they bind and ..
  9. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2000
    ..nuclear receptor steroidogenic factor1 (SF-1), originally isolated as a regulator of the cytochrome P450 steroid hydroxylases, plays essential roles in endocrine development and function...
  10. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2001
    ..nuclear receptor steroidogenic factor1 (SF-1), originally isolated as a regulator of the cytochrome P450 steroid hydroxylases, plays essential roles in endocrine development and function...
  11. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2002
    ..nuclear receptor steroidogenic factor1 (SF-1), originally isolated as a regulator of the cytochrome P450 steroid hydroxylases, plays essential roles in endocrine development and function...
  12. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 1999
    ..nuclear receptor steroidogenic factor1 (SF-1), originally isolated as a regulator of the cytochrome P450 steroid hydroxylases, plays essential roles in endocrine development and function...
  13. STEROID HYDROXYLASES STUDIES
    TOKUJI KIMURA; Fiscal Year: 1980
    ..By means of reconstitution of these components into a system close to that in the native system of adrenal cortex, we hope to be able to understand the relationship between the steroidogenesis and the action of ACTH...
  14. STAR AND SF-1: ESTROGEN SYNTHESIS AND BREAST CANCER RISK
    Robert Haile; Fiscal Year: 2000
    ..cell-type specific and hormonal expression of many steroidogenic enzymes, including the cytochrome p450 steroid hydroxylases and StAR...
  15. STEROID HYDROXYLASES IN NORMAL AND ABNORMAL ADRENALS
    BOYD HARDING; Fiscal Year: 1980
    ..Their function will be studied by determining their relationship to protein kinases and phosphodiesterases and by examining their effects on cholesterol transport to mitochondrial P450scc and upon the catalytic activity of this enzyme. ..
  16. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2008
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  17. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2009
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  18. Advances in Mineral Metabolism (AIMM) annual meeting
    Rene St Arnaud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  19. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2006
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  20. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  21. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  22. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  23. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2007
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  24. Vitamin D Ligands and Regulation of Calcium Homeostasis
    J Pike; Fiscal Year: 2009
    ..These concepts will enable more rationale approaches to the design and synthesis of therapeutically relevant vitamin D analogues. ..
  25. MECHANISMS OF GENE SELECTIVITY IN VITAMIN D SIGNALING
    J Pike; Fiscal Year: 2001
    ....
  26. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2001
    ..These determinants may be exploited together with novel vitamin D analogues in the treatment of bone diseases exemplified by osteoporosis and hypeproliferative diseases such as psoriasis and cancer. ..
  27. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2009
    ..The studies herein seek to enhance our understanding of the mechanisms that underlie vitamin D action in bone cells such that better and more selective medicines can be created. ..
  28. ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATION
    J Pike; Fiscal Year: 2002
    ..As in Specific Aim 1, the activity of SERMs in osteoclast differentiation will be evaluated. ..
  29. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2002
    ..These determinants may be exploited together with novel vitamin D analogues in the treatment of bone diseases exemplified by osteoporosis and hypeproliferative diseases such as psoriasis and cancer. ..
  30. ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATION
    J Pike; Fiscal Year: 2001
    ..As in Specific Aim 1, the activity of SERMs in osteoclast differentiation will be evaluated. ..
  31. ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATION
    J Pike; Fiscal Year: 2003
    ..As in Specific Aim 1, the activity of SERMs in osteoclast differentiation will be evaluated. ..
  32. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2006
    ..abstract_text> ..
  33. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2007
    ..abstract_text> ..
  34. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2005
    ..abstract_text> ..
  35. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2009
    ..The studies herein seek to identify the mechanisms that underlie the expression of this factor such that better and more selective medicines can be created. ..
  36. Vitamin D Ligands and Regulation of Calcium Homeostasis
    J Wesley Pike; Fiscal Year: 2010
    ..These concepts will enable more rationale approaches to the design and synthesis of therapeutically relevant vitamin D analogues. ..
  37. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Wesley Pike; Fiscal Year: 2010
    ..The studies herein seek to determine the mechanisms that control expression of the vitamin D receptor in tissues such that better and more selective medicines can be created. ..
  38. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2009
    ..These studies will provide important detail into the mechanism by which calciotropic hormones and cytokines regulate RANKL expression, a gene whose product is central to bone resorption. ..
  39. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2008
    ..These studies will provide important detail into the mechanism by which calciotropic hormones and cytokines regulate RANKL expression, a gene whose product is central to bone resorption. ..
  40. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2007
    ..These studies will provide important detail into the mechanism by which calciotropic hormones and cytokines regulate RANKL expression, a gene whose product is central to bone resorption. [unreadable] [unreadable] [unreadable]..
  41. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2008
    ..abstract_text> ..
  42. Vitamin D Ligands and Regulation of Calcium Homeostasis
    J Pike; Fiscal Year: 2008
    ..The studies herein seek to enhance our understanding of the mechanisms that underlie vitamin D action such that better and more selective medicines can be created. [unreadable] [unreadable] [unreadable]..
  43. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2009
    ..The studies herein seek to determine the mechanisms that control expression of the vitamin D receptor in tissues such that better and more selective medicines can be created. ..
  44. Significance of CYP46A1 and other P450s in retinal function
    Irina Pikuleva; Fiscal Year: 2007
    ..Relevance (for lay audience). This research will be critical for understanding the development of certain eye diseases that reduce vision. ..
  45. Cholesterol-metabolizing P450s and Alzheimer's disease
    Irina Pikuleva; Fiscal Year: 2007
    ..If funded, the release time and salary support will significantly enhance the P.I.'s career in basic science research and make it more medically oriented. ..
  46. Cholesterol-metabolizing P450s and Alzheimer's disease
    Irina Pikuleva; Fiscal Year: 2008
    ..If funded, the release time and salary support will significantly enhance the P.I.'s career in basic science research and make it more medically oriented. ..
  47. Significance of CYP46A1 and other P450s in retinal function
    Irina Pikuleva; Fiscal Year: 2008
    ..Relevance (for lay audience). This research will be critical for understanding the development of certain eye diseases that reduce vision. ..
  48. CA++ BINDING PROTEINS AND THE VITAMIN D ENDOCRINE SYSTEM
    Sylvia Christakos; Fiscal Year: 1993
    ....
  49. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2005
    ..abstract_text> ..
  50. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2009
    ....
  51. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2002
    ....
  52. VITAMIN D HORMONE--FUNCTION AND MECHANISM OF ACTION
    Sylvia Christakos; Fiscal Year: 1999
    ....
  53. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  54. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2006
    ....
  55. CA++ BINDING PROTEINS AND THE VITAMIN D ENDOCRINE SYSTEM
    Sylvia Christakos; Fiscal Year: 1990
    ..Additionally, this study may lead to an increased understanding of the role of the vitamin D endocrine system in normal brain function as well as in brain disorder involving calcium dependent functions...
  56. CA++ BINDING PROTEINS AND THE VITAMIN D ENDOCRINE SYSTEM
    Sylvia Christakos; Fiscal Year: 1991
    ..Additionally, this study may lead to an increased understanding of the role of the vitamin D endocrine system in normal brain function as well as in brain disorder involving calcium dependent functions...
  57. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2007
    ..abstract_text> ..
  58. VITAMIN D P450 FUNCTION--NATURAL & DIRECTED MUTAGENESIS
    John Omdahl; Fiscal Year: 2000
    ....
  59. VITAMIN D HORMONE--FUNCTION AND MECHANISM OF ACTION
    Sylvia Christakos; Fiscal Year: 2000
    ....
  60. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2008
    ....
  61. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2004
    ....
  62. Comparison of CYP2 Genes Across Mammal Species
    Susan Hoffman; Fiscal Year: 2004
    ..abstract_text> ..
  63. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2004
    ..abstract_text> ..
  64. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2010
    ..Since estrogens are prerequisites for breast cancer, delineating the regulatory effects of LXRs on EST/SULT1E1 expression may have a broader significance in the understanding of breast cancer prevention and treatment. ..
  65. Immune Responses of the Epithelium in Chronic Rhinosinusitis with Polyps
    Andrew Lane; Fiscal Year: 2007
    ..These combined studies described in the proposal will significantly advance current knowledge about CRSwNP and potentially lead to innovative therapies for this debilitating and costly medical condition. ..
  66. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  67. Colon-specific Transgenic Mouse for Cancer Research
    JAMES FLEET; Fiscal Year: 2007
    ..In addition, colon cancer models made with the new transgenic mouse will be useful for testing agents for their ability to treat and prevent cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  68. Vitamin D Fluctuations and the Mucosal Immune Response
    MARGHERITA CANTORNA; Fiscal Year: 2009
    ....
  69. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2007
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  70. Vitamin D Status and Prostate Cancer
    JAMES FLEET; Fiscal Year: 2007
    ..These data will provide us with the mechanistic basis for dietary recommendations to prevent prostate cancer and optimize bone health. ..
  71. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2008
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  72. The Interaction Between Hepatic Insulin Resistance and Cholesterol Metabolism
    Sudha Biddinger; Fiscal Year: 2007
    ..C. Ronald Kahn, and be well positioned to make significant scientific and medical contributions to the understanding of insulin resistance in children and adolescents. ..
  73. Intestinal calcium absorption: molecular mechanisms
    JAMES FLEET; Fiscal Year: 2007
    ..g. when vitamin D resistance associated with aging or estrogen deficiency is present. ..
  74. Enzymes of Skin Lipid Metabolism
    David Russell; Fiscal Year: 2007
    ..The research is relevant to skin disease, dry eye syndrome, and cholesterol metabolism. ..
  75. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  76. Phase II UDP-glucuronosyltransferases by PXR
    Wen Xie; Fiscal Year: 2004
    ..These include bilirubin and hormonal homeostasis, drug metabolism, and chemical carcinogenesis. ..
  77. ANTITUMOR MECHANISMS & THERAPEUTIC EFFECTS OF VITAMIN D
    Candace Johnson; Fiscal Year: 2000
    ....
  78. PXR Controlled Bile Acid Detoxification in Colon Cancer
    Wen Xie; Fiscal Year: 2004
    ..It is anticipated that the development of selective PXR agonists may represent a novel strategy to eliminate toxic bile acids and to prevent colon cancer. ..
  79. Cytochrome P450 in Nicotine Metabolism
    Sharon Murphy; Fiscal Year: 2004
    ....
  80. ENDOCRINE ROLES OF STEROID 5 ALPHA REDUCTASE ISOZYMES
    David Russell; Fiscal Year: 2000
    ....
  81. Anti-tumor Mechanisms & Therapeutic Effects of Vitamin D
    Candace Johnson; Fiscal Year: 2004
    ..of the tyrosine kinase inhibitor, ZD 1839 in combination with calcitriol in vitro and in vivo and 4) to examine in the Phase I setting ZD1839 250mg,QD) with escalating high iv doses of calcitriol weekly in patients with advanced cancer ..