Genomes and Genes
Summary: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Publications246 found, 100 shown here
- Vitamin D: more than a "bone-a-fide" hormoneAmelia L M Sutton
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Mol Endocrinol 17:777-91. 2003....
- Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in ChineseBinbin Wang
Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Neurosci Lett 369:104-7. 2004..32, P < 0.001). Our data reveal that the polymorphism of CYP46 intron 2 is implicated in the susceptibility to LOAD and a strong synergistic interaction between CYP46 TT homozoygots and APOE epsilon4 carrier status on the risk of LOAD...
- Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesisSongyang Ren
Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Biol Chem 280:20604-11. 2005..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
- Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharideUlf Diczfalusy
Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
J Lipid Res 50:2258-64. 2009..The possibility is discussed that 25-hydroxycholesterol may have a role in the inflammatory response, in addition to its more established role in the regulation of cholesterol homeostasis...
- Brain cholesterol turnover required for geranylgeraniol production and learning in miceTiina J Kotti
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 103:3869-74. 2006..We conclude that cholesterol turnover in brain activates the mevalonate pathway and that a constant production of geranylgeraniol in a small subset of neurons is required for LTP and learning...
- CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinomaGuoan Chen
Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 17:817-26. 2011..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells...
- 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A productionDavid R Bauman
Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:16764-9. 2009..The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system...
- Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnoverErik G Lund
Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 278:22980-8. 2003..We conclude that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain...
- Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesionsNair Lopes
Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
BMC Cancer 10:483. 2010..We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions...
- Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylationK Rose
Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, King s Buildings, Edinburgh EH9 3JQ, United Kingdom
J Biol Chem 276:23937-44. 2001..CYP7B is thus a major extrahepatic steroid and oxysterol hydroxylase and provides the predominant route for local metabolism of DHEA and related molecules in brain and other tissues...
- Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axesYoshihiko Ohyama
Divisions of Clinical Chemistry and Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
J Biol Chem 281:3810-20. 2006..The failure to demonstrate a significant transcriptional regulation under most conditions is discussed in relation to the turnover of brain and neuronal cholesterol...
- Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø StudyRolf Jorde
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, and Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
PLoS ONE 7:e37295. 2012..Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health...
- 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processesYohan Bosse
McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
Physiol Genomics 29:161-8. 2007..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
- Oxysterol biosynthetic enzymesD W Russell
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9046, USA
Biochim Biophys Acta 1529:126-35. 2000..This article focuses on the properties of these enzymes...
- Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresisRebecca Schule
Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
J Lipid Res 51:819-23. 2010..If the accumulation of 27-hydroxycholesterol is an important pathogenetic factor, a reduction of its levels may reduce or prevent the neurological symptoms. A possible strategy to achieve this is discussed...
- CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24Rene St-Arnaud
Genetics Unit, Shriners Hospital for Children, and Department of Human Genetics, Medicine and Surgery, McGill University, Montreal, Quebec, Canada H3A 2T5
J Steroid Biochem Mol Biol 121:254-6. 2010....
- Expression of VDR and CYP24A1 mRNA in human tumorsMark G Anderson
Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
Cancer Chemother Pharmacol 57:234-40. 2006..These data suggest that the VDR signaling pathway may be compromised via the modulation of CYP24A1 and VDR in human tumors...
- 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligandYan Ru Lou
Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
J Steroid Biochem Mol Biol 118:162-70. 2010..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
- Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferonsKiwon Park
The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Leukoc Biol 88:1081-7. 2010....
- Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brainDavid W Russell
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Annu Rev Biochem 78:1017-40. 2009..This review focuses on how the link between cholesterol metabolism and higher-order brain function was experimentally established...
- cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismE G Lund
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
J Biol Chem 273:34316-27. 1998....
- Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytesLionel Drocourt
INSERM U128, Institut Federatif de Recherche 24, CNRS, 1919 Route de Mende, 34293 Montpellier, Cedex 05, France
J Biol Chem 277:25125-32. 2002..In conclusion, this work suggests that VDR, PXR, and CAR control the basal and inducible expression of several CYP genes through competitive interaction with the same battery of responsive elements...
- Disruption of the oxysterol 7alpha-hydroxylase gene in miceJ Li-Hawkins
Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
J Biol Chem 275:16536-42. 2000..A failure to catabolize oxysterols in the male kidney may lead to a decrease in de novo sterol synthesis...
- Vitamin D-related genes, serum vitamin D concentrations and prostate cancer riskJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Carcinogenesis 30:769-76. 2009..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
- Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancerMarjorie L McCullough
Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA
Annu Rev Nutr 29:111-32. 2009..Currently, there is no strong, consistent epidemiologic evidence for substantial influences of single variants in vitamin D pathway genes on risk for colorectal, breast, or prostate cancer, but promising leads are developing...
- Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsKristin K Deeb
Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
Nat Rev Cancer 7:684-700. 2007..Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents...
- Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcificationHaiqing Shen
Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arterioscler Thromb Vasc Biol 30:2648-54. 2010..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
- Exploring the genetic architecture of circulating 25-hydroxyvitamin DLinda T Hiraki
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Genet Epidemiol 37:92-8. 2013..The absence of a significant polygenic effect in this relatively large sample suggests an oligogenetic architecture for 25(OH)D...
- Cholesterol 25-hydroxylation activity of CYP3AAkira Honda
Department of Gastroenterology, Center for Collaborative Research, Ibaraki 300 0395, Japan
J Lipid Res 52:1509-16. 2011..650, P < 0.0001, n = 78), but did not significantly correlate with the levels of 27-hydroxycholesterol or 24S-hydroxycholesterol. These results demonstrate the significance of CYP3A on the production of 25-hydroxycholesterol...
- Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostateKristin K Deeb
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute Buffalo, NY USA
Epigenetics 6:994-1000. 2011....
- 8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanismJudith A Enyeart
Department of Neuroscience, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210 1269, USA
Am J Physiol Endocrinol Metab 301:E941-54. 2011..8CPT-2'-OMe-cAMP, but not 8HPT-2'-OMe-cAMP or 8MeOPT-2'-OMe-cAMP, induced mRNAs for CYP17 and CYP11a1 steroid hydroxylases and stimulated cortisol synthesis...
- The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxificationFrederic Gachon
Department of Molecular Biology, National Center of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 1211 Geneva 4, Switzerland
Cell Metab 4:25-36. 2006..Indeed, PAR bZip triple knockout mice are hypersensitive to xenobiotic compounds, and the deficiency in detoxification may contribute to their early aging...
- CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancerRobert A Parise
The University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Int J Cancer 119:1819-28. 2006..These data suggest that increased CYP24 expression in lung tumors restricts 1,25D3 activity and support the preclinical evaluation of CYP24 inhibitors for lung cancer treatment...
- Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiationSheng Chen
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:1634-47. 2007..These results indicate that 1,25(OH)(2)D(3) may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders...
- CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functionsAshlee R Stiles
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 284:28485-9. 2009..The role of CYP7B1 in brain is under investigation; recent studies show that spastic paraplegia type 5, a progressive neuropathy, is caused by loss-of-function mutations in the human gene...
- Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob miceAyako Matsunuma
Department of Biochemistry, Ohu University School of Dentistry, Koriyama 963 8611, Japan
Endocrinology 145:1367-75. 2004..Therefore, low BMD in leptin-deficient mice appears to be related to stimulation of bone resorption by 1,25-(OH)(2)D(3)...
- Vitamin D pathway gene variants and prostate cancer prognosisSarah K Holt
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Prostate 70:1448-60. 2010..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
- Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylaseJeffrey B Cheng
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 101:7711-5. 2004..These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency...
- Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetesJason D Cooper
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Diabetes 60:1624-31. 2011....
- Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levelsCynthia Fourgeux
Eye and Nutrition Research Group, UMR1129 FLAVIC Flaveur, vision et comportement du consommateur Flavor, Vision, and Consumer Behavior, INRA French National Institute for Agricultural Research, Dijon, France
Invest Ophthalmol Vis Sci 50:5712-7. 2009....
- Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytesTara I Ellison
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Biol Chem 282:10953-62. 2007..Cumulatively, these studies support the concept that transactivation by VDR in keratinocytes may be uncoupled from the 1,25(OH)2D3 ligand...
- Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer riskLinda M Dong
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results...
- A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3Mark B Meyer
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
J Biol Chem 285:15599-610. 2010..We conclude that a more complex mechanism is responsible for the striking CYP24A1 up-regulation induced by the vitamin D hormone in target cells...
- Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosisK Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Mult Scler 16:133-8. 2010..The finding of a marginally significant gene-environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context...
- Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brainI Bjorkhem
Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Sweden
J Intern Med 260:493-508. 2006..An overview of the above studies is presented and the possibility that the cholesterol 24S-hydroxylase in the brain may be important for memory and learning and that it may be a new drug target is discussed...
- Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivoJillian Ross
CXR Biosciences Ltd, 2 James Lindsay Place, Dundee DD1 5JJ, UK
Toxicol Sci 116:452-66. 2010..However, all parameters investigated to date suggest that much of their functionality is maintained...
- Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancerWei Luo
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 70:5953-62. 2010..Our findings indicate that repression of CYP24A1 gene expression in human prostate cancer cells is mediated in part by promoter DNA methylation and repressive histone modifications...
- Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125bSayaka Komagata
Drug Metabolism and Toxicology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Mol Pharmacol 76:702-9. 2009..In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24, which serves as a possible mechanism for the high CYP24 expression in cancer tissues...
- The vitamin D/CYP24A1 story in cancerAmanda N King
Department of Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Anticancer Agents Med Chem 10:213-24. 2010..The following review summarizes the available literature on CYP24A1 as it relates to 1,25(OH)(2)D(3) in cancer and outlines potential ways to inhibit CYP24A1 in an effort to improve the efficacy of exogenous 1,25(OH)(2)D(3)...
- 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cellsYan Ru Lou
Department of Anatomy, Medical School, FIN 33014, University of Tampere, Finland
FASEB J 18:332-4. 2004..Altogether our results suggest that 25OHD3 at a high but physiological concentration acts as an active hormone with respect to vitamin D3 responsive gene regulation and suppression of cell proliferation...
- Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulationI Bjorkhem
Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Sweden
J Lipid Res 39:1594-600. 1998..The possibility is discussed that circulating levels of 24S-hydroxycholesterol can be used as a marker for pathological and/or developmental changes in the brain...
- 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cellsGuido Heine
Allergy Center Charité, CCM, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur J Immunol 38:2210-8. 2008....
- Influence of 1,25-dihydroxy vitamin D3 on TLR4-induced activation of antigen presenting cells is dependent on the order of receptor engagementVandana Gambhir
Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
Immunobiology 216:988-96. 2011..Consequently, engagement of VDR by 1,25-(OH)₂D₃ can partially interfere with TLR-4-L-induced activation of pAPCs only when it occurs before TLR-4 stimulation...
- New insights into the mechanisms of vitamin D actionSylvia Christakos
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
J Cell Biochem 88:695-705. 2003..Thus in recent years a number of exciting discoveries have been made that have enhanced our understanding of mechanisms involved in the pleiotropic actions of 1,25(OH)(2)D(3)...
- Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Mol Psychiatry 7:899-902. 2002..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
- Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cellsMaya Khorchide
Department of Pathophysiology, Medical University of Vienna, A 1090 Vienna, Waehringerguertel 18 20, Austria
J Steroid Biochem Mol Biol 93:167-72. 2005..This demonstrates for the first time that synthesis of 1,25-dihydroxycholecalciferol in human prostate tumors could be reinitiated by epigenetic regulators...
- Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouseSonoko Masuda
Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
Endocrinology 146:825-34. 2005..These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis...
- Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase geneH Rosen
Department of Molecular Virology, Faculty of Medicine, Hebrew University, 91120 Jerusalem, Israel
J Biol Chem 273:14805-12. 1998..The results do not support the contention that 27-hydroxylated steroids are critical for maintenance of cholesterol homeostasis or levels of vitamin D metabolites in the circulation...
- Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1betaJohn Dulos
Organon NV, Oss, The Netherlands
Arthritis Rheum 50:3346-53. 2004..This study was undertaken to investigate the putative role of CYP7B in arthritis using murine collagen-induced arthritis (CIA), an interleukin-1beta (IL-1beta)-dependent model...
- 25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancerEduardo Carneiro de Lyra
Instituto Brasileiro de Controle do Cancer, Av Alcântara Machado 2576, São Paulo SP CEP 03102 002, Brazil
J Steroid Biochem Mol Biol 100:184-92. 2006..A low 1,25(OH)2D3 serum concentration seems to be associated to breast cancer, however, the mechanism involved in this regulation is still unclear...
- Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylasesY Ikeda
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
Mol Endocrinol 8:654-62. 1994..studied the developmental profile of steroidogenic factor-1 (SF-1), a nuclear receptor that regulates the steroid hydroxylases. SF-1 transcripts first appear on embryonic day 9 (E9) in the urogenital ridge, the probable source of ..
- A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cellsDaniel Lechner
Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Pharmacol Exp Ther 320:1119-26. 2007..Yet, S-4a imparts antimitotic activity to 1alpha,25-(OH)(2)D(3) and may therefore constitute a therapeutic to stimulate the antiproliferative potential of vitamin D-based antitumor activity...
- Steroid and sterol 7-hydroxylation: ancient pathwaysRichard Lathe
Division of Biomedical Sciences, University of Edinburgh, George Square, EH9 9XD, Edinburgh, UK
Steroids 67:967-77. 2002..Early receptor targets probably included intracellular sterol sites, some modern steroids may continue to act at these targets. 7-Hydroxylation of DHEA may reflect conservation of an early signaling pathway...
- 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progressionP Bareis
Department of Pathophysiology, University of Vienna Medical School, Vienna, A-1090, Austria
Biochem Biophys Res Commun 285:1012-7. 2001....
- QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cellsSujatha Sundaram
Department of Surgery, Dartmouth Medical School, One Medical Center Drive, HB 7850, Lebanon, NH 03756, USA
Mol Cancer Ther 5:2806-14. 2006..QW also blocked the sustained induction of CYP24 expression by 1,25(OH)(2)D(3) and EB 1089, increased the potency of 1,25(OH)(2)D(3) and EB 1089, and inhibited breast tumor cell proliferation and invasion...
- Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: breaking paradigmsLorenza Díaz
Departamento de Biologia de la Reproduccion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico DF, Mexico
Cytokine 55:188-94. 2011..Altogether, our results offer new insights into the mechanisms whereby PRL is regulated in immune cells...
- Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestineCatherine Theodoropoulos
Departement de Pharmacologie, Faculte de Medecine, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Quebec, Canada
Clin Endocrinol (Oxf) 58:489-99. 2003..Total RNA was extracted and cDNA synthesized by RT-PCR. The cDNA obtained was amplified by radioactive PCR, the signal intensity evaluated by densitometric analyses and expressed in relation to the levels of GAPDH...
- CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokinesJohn Dulos
University Medical Center Utrecht, The Netherlands
Arthritis Rheum 52:770-8. 2005..The purpose of this study was to investigate the presence of 7alpha-OH-DHEA in synovial samples and the cytokine regulation of CYP7B activity in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
- The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cellsJuha M Matilainen
Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
J Biol Chem 285:24174-83. 2010..In conclusion, our data suggest that in comparison to normal cells, clearing of 1alpha,25(OH)(2)D(3) is enhanced in malignant cells due to differences in transcriptional regulation of CYP24 and metabolism of CYP24 mRNA...
- Vitamin D analogues targeting CYP24 in chronic kidney diseaseGary H Posner
Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA
J Steroid Biochem Mol Biol 121:13-9. 2010..Studies with both new analogues underscore the potential utility of CYP24 inhibition in the treatment of secondary hyperparathyroidism in CKD...
- Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized ratsFumi Takemoto
Kidney Center, Toranomon Hospital, Tokyo, Japan
Kidney Int 64:414-20. 2003....
- The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesisHenrik C Horváth
Department of Medicine, Semmelweis University, Budapest, Hungary
J Histochem Cytochem 58:277-85. 2010..A parallel increased expression of the proliferation marker Ki-67 in the same samples suggests that overexpression of CYP24A1 reduced local 1,25-D(3) availability, decreasing its antiproliferative effect...
- No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)Jörg Reichrath
Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
J Steroid Biochem Mol Biol 89:163-6. 2004..Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM...
- Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese womenTsogzolmaa Dorjgochoo
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Cancer Epidemiol Biomarkers Prev 20:2313-6. 2011..Previous studies evaluating the association of vitamin D-related genetic variants with breast cancer risk have produced inconsistent results...
- CYP46: a risk factor for Alzheimer's disease or a coincidence?Ewa Golanska
Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
Neurosci Lett 383:105-8. 2005..However, considering the extreme divergence of results obtained by different authors, a clear connection between the CYP46 gene and AD is questionable...
- Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's diseaseValentina Fernández Del Pozo
Servicio de Neurologia, Hospital Cruces, Barakaldo, Spain
Dement Geriatr Cogn Disord 21:81-7. 2006....
- Genetic association of CYP46 and risk for Alzheimer's diseaseOnofre Combarros
Neurology Service, Marqués de Valdecilla University Hospital University of Cantabria, Santander, Spain
Dement Geriatr Cogn Disord 18:257-60. 2004..Our results indicate that the intron 2 CYP46 C/C genotype may predispose to AD, and this association is independent of the apolipoprotein E genotype...
- Cyp46 polymorphisms in Alzheimer's disease: a reviewAnália Nusya Medeiros Garcia
Instituto de Ciencias Biologicas, UPE, Recife, Brazil
J Mol Neurosci 39:342-5. 2009..The aim of this review is to describe and summarize the findings of the researches about the relationship between CYP46 and AD that have been published in the past 9 years...
- Dysregulation of renal vitamin D metabolism in the uremic ratChristian F Helvig
Department of Research and Development, Cytochroma Inc, 330 Cochrane Drive, Markham, Ontario, Canada
Kidney Int 78:463-72. 2010..Thus, our findings suggest that dysregulation of CYP24 may be a significant mechanism contributing to vitamin D insufficiency and resistance to vitamin D therapy in CKD...
- Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3Gerald J Atkins
Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
Bone 40:1517-28. 2007..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
- 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogueUlrika Segersten
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Breast Cancer Res 7:R980-6. 2005..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...
- CYP24A1 inhibition enhances the antitumor activity of calcitriolJosephia R Muindi
Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
Endocrinology 151:4301-12. 2010....
- Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retinaLionel Bretillon
Eye and Nutrition Research Group, UMR 1129 FLAVIC, INRA, ENESAD, University of Burgundy, Dijon, France, and Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
Curr Eye Res 32:361-6. 2007....
- Selective inhibition of vitamin D hydroxylases in human keratinocytesI Schuster
Novartis Research Institute, Vienna, Austria
Steroids 66:409-22. 2001..Besides their use as valuable tools in elucidating regulatory mechanisms, inhibitors of VD hydroxylases may give rise to novel therapeutic strategies, especially in defects of cell growth and differentiation...
- RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cellsPaloma Ordonez-Moran
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
J Cell Biol 183:697-710. 2008..Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1...
- Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brainDenise M O Ramirez
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Comp Neurol 507:1676-93. 2008..These findings reveal the microsomal localization of 24-hydroxylase and provide subcellular insight into cholesterol turnover in the brain...
- Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3Sami Väisänen
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
J Mol Biol 350:65-77. 2005....
- Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasisLi Laine Ooi
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
Cancer Res 70:1835-44. 2010..These effects are partly mediated through secondary changes in the bone microenvironment, along with direct effects of vitamin D on tumor growth...
- Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patientsY Li
Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China
Dement Geriatr Cogn Disord 22:399-404. 2006..Genetic association of CYP46A1 polymorphisms with AD had been under extensive investigations; however, observations on intron 2 T-->C (rs754203) generated inconclusive results...
- TNF-alpha interferes with lipid homeostasis and activates acute and proatherogenic processesKlementina Fon Tacer
Center for Functional Genomics and Biochips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
Physiol Genomics 31:216-27. 2007..Observed acute alterations in lipid metabolism are in agreement with chronic disturbances found in patients...
- Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathwayMatthias Wjst
Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
Respir Res 7:60. 2006....
- Vitamin D metabolism and action in human bone marrow stromal cellsShuanhu Zhou
Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Endocrinology 151:14-22. 2010....
- In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cellsJörg Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg Germany
Cancer Biol Ther 6:48-55. 2007....
- RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cellsP H Anderson
Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
J Steroid Biochem Mol Biol 103:601-5. 2007....
- Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulatorsBarbara Borroni
Neurologic Clinic, University of Brescia, Spedali Civili de Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy
Neurobiol Aging 25:747-51. 2004..02). These findings provide direct evidence that CYP46 and ApoE polymorphisms synergically increase the risk for AD development, and influence on the rate of cognitive decline...
- Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elementsK S Chen
Department of Biochemistry, University of Wisconsin Madison, 53706, USA
Biochim Biophys Acta 1263:1-9. 1995..Further characterization of these VDREs in various constructs with either a native or TK promoter suggests that both VDREs are required for the optimal induction of 24-hydroxylase expression by 1,25-(OH)2D3...
- The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytesZhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
J Biol Chem 277:36987-90. 2002..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis...
- CYP27A1 and CYP24 expression as a function of malignant transformation in the colonDamien Matusiak
Department of Medicine, University of Illinois at Chicago, 840 S Wood St M C 716, Chicago, IL 60612, USA
J Histochem Cytochem 55:1257-64. 2007..These data indicate that non-toxic vitamin D precursors should be sufficient for CRC chemoprevention, but that neither vitamin D nor its precursors may be sufficient for CRC chemotherapy...
- 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesisH S Cross
Department of Pathophysiology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090, Vienna, Austria
Steroids 66:287-92. 2001....
- The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolismP Wei
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 407:920-3. 2000..Thus, loss of CAR function alters sensitivity to toxins, increasing or decreasing it depending on the compound. Modulation of CAR activity in humans may significantly affect metabolism of drugs and other xenobiotics...
- Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2Min Cui
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47906 2059, USA
J Cell Physiol 219:132-42. 2009..Our data show that there are both promoter-specific and cell stage-specific roles for the ERK signaling pathway on 1,25(OH)(2)D(3)-mediated gene induction in enterocyte-like Caco-2 cells...
- ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLSMichael Waterman; Fiscal Year: 2002..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
- REGULATION OF CYTOCHROME P450'S IN ADRENALVIRGINIA BLACK; Fiscal Year: 1992..This 52K protein does not react with antibodies against known adrenal microsomal steroid hydroxylases (P45021 and P45017alpha), but does react with antibody against methylcholanthrene-induced P450s in rat ..
- STAR AND SF-1: ESTROGEN SYNTHESIS AND BREAST CANCER RISKRobert Haile; Fiscal Year: 2000..cell-type specific and hormonal expression of many steroidogenic enzymes, including the cytochrome p450 steroid hydroxylases and StAR...
- STEROID HYDROXYLASES IN NORMAL AND ABNORMAL ADRENALSBOYD HARDING; Fiscal Year: 1980..Their function will be studied by determining their relationship to protein kinases and phosphodiesterases and by examining their effects on cholesterol transport to mitochondrial P450scc and upon the catalytic activity of this enzyme. ..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2010..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- Advances in Mineral Metabolism (AMM) meetingRene St Arnaud; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Advances in Mineral Metabolism (AIMM) annual meetingRene St Arnaud; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATIONJ Pike; Fiscal Year: 2003..As in Specific Aim 1, the activity of SERMs in osteoclast differentiation will be evaluated. ..
- MECHANISMS OF GENE SELECTIVITY IN VITAMIN D SIGNALINGJ Pike; Fiscal Year: 2001....
- VITAMIN D P450 FUNCTION--NATURAL & DIRECTED MUTAGENESISJohn Omdahl; Fiscal Year: 2002....
- Comparison of CYP2 Genes Across Mammal SpeciesSusan Hoffman; Fiscal Year: 2004..abstract_text> ..
- Immune Reactants, Cholesterol and AtherosclerosisALLISON REISS; Fiscal Year: 2006..abstract_text> ..
- VITAMIN D AND MAMMARY GLANDJoEllen Welsh; Fiscal Year: 2009..These studies will provide mechanistic detail on the functions of the vitamin D signaling pathway in mammary gland in relation to prevention and treatment of breast cancer. ..
- The Hepatoprotective Role of the Orphan Nuclear Receptor LXRWen Xie; Fiscal Year: 2010..It is hoped that the development of selective LXR agonists may represent a novel strategy for the prevention and treatment of APAP-induced hepatotoxicity. ..
- Scientific Meeting: Mechanisms of Cell DeathZahra Zakeri; Fiscal Year: 2006..We are currently negotiating publication arrangements. NIH funds will be used to support speakers and facilities. Future meetings in France and China are planned. [unreadable] [unreadable] [unreadable]..
- Ontogeny of Drug Bioactivation and Idiosyncratic ADRsJAMES LEEDER; Fiscal Year: 2007..abstract_text> ..
- Prx1 in malignant progression of prostate cancerCandace S Johnson; Fiscal Year: 2010..This study will also provide a soundscientific basis upon which the role ofPrxl canbe elucidatedin prostate cancer, enabling the development of novelprognostic/therapeutic approaches to inhibit its malignant progression. ..
- Genomic Analysis of ER Negative Breast CancerDonna Albertson; Fiscal Year: 2007..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
- PXR Controlled Bile Acid Detoxification in Colon CancerWen Xie; Fiscal Year: 2008..It is anticipated that the development of selective PXR agonists may represent a novel strategy to eliminate toxic bile acids and to prevent colon cancer. ..
- Microarray-Based Scanning of the Mouse GenomeDonna Albertson; Fiscal Year: 2008..New approaches for hybridization and analysis will be developed to extend the dynamic range of the expression measurements so we can obtain data from mRNAs expressed at very low abundances. [unreadable] [unreadable] [unreadable]..
- Vitamin D Status and Prostate CancerJAMES FLEET; Fiscal Year: 2008..These data will provide us with the mechanistic basis for dietary recommendations to prevent prostate cancer and optimize bone health. ..
- Colon-specific Transgenic Mouse for Cancer ResearchJAMES FLEET; Fiscal Year: 2008..In addition, colon cancer models made with the new transgenic mouse will be useful for testing agents for their ability to treat and prevent cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
- MOLECULAR GENETIC STUDIES OF PLANT STEROID SIGNALINGJianming Li; Fiscal Year: 2008....
- Blood-based lipid biomarkers reflective of Alzheimer-associated neurodegenerationMichelle Mielke; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Vitamin D Regulation of Inflammatory Bowel DiseaseMARGHERITA CANTORNA; Fiscal Year: 2008..A better understanding of the mechanisms underlying vitamin D regulation of T cells and IBD may lead to improved therapies for patients with IBD. [unreadable] [unreadable] [unreadable]..
- High Resolution Genomic Analysis of Amplicon StructureDonna Albertson; Fiscal Year: 2007..abstract_text> ..
- PROSTATE CANCER, CALCIUM AND VITAMIN DJoEllen Welsh; Fiscal Year: 2007..abstract_text> ..
- Genomic and Functional Analysis of Oral Cancer DevelopmentDonna Albertson; Fiscal Year: 2009..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
- Regulation of Sulfotransferases by LXR and its Implication in PathophysiologyWen Xie; Fiscal Year: 2011..Since estrogens are prerequisites for breast cancer, delineating the regulatory effects of LXRs on EST/SULT1E1 expression may have a broader significance in the understanding of breast cancer prevention and treatment. ..
- Cell Death Society Symposium on Targeting Cell Death Pathways for Human DiseasesZahra Zakeri; Fiscal Year: 2008..Our meeting will address the idea of how to go from basic research to development of methods for therapeutic interventions and targeting cell death pathways for human diseases. [unreadable] [unreadable] [unreadable]..
- Cytokines on Olfactory Receptor Neuron FunctionAndrew Lane; Fiscal Year: 2006..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
- Chemoprevention/Therapy Using Non-Calcemic Vitamin DGary Posner; Fiscal Year: 2006..Collectively, these studies will provide important structure- activity insights into the cancer chemoprotective and chemotherapeutic actions and molecular biology of vitamin D3 analogs. ..
- Amplicon Profiling by Array CGHDonna Albertson; Fiscal Year: 2004..abstract_text> ..
- Fusion Proteins As Probes of P450 Structure and FunctionRichard Auchus; Fiscal Year: 2004..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
- VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSESMARGHERITA CANTORNA; Fiscal Year: 2004..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
- AUTOREGULATION AND HYPOXIC DILATION IN THE BRAINDavid Harder; Fiscal Year: 2002..They will also determine if there is linkage between increased P450 w-hydroxylase activity in response to increasing transmural pressure and the cerebral vascular responses to changes in PO2. ..
- PATHOGENESIS OF ANTICONVULSANT HYPERSENSITIVITY SYNDROMEJAMES LEEDER; Fiscal Year: 2003..It is anticipated that the basic experimental paradigm employed for these studies can also be applied to other idiosyncratic toxicities with suspected drug bioactivation and immune etiologies. ..
- MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLORMary Beth Genter; Fiscal Year: 2002....
- Molecular Genetics of the HPA(I) AxisPhillip Danielson; Fiscal Year: 2002....
- PLANT SPHINGOLIPIDS AND CARCINOGENESISDirck Dillehay; Fiscal Year: 2001..These studies could lead to a better understanding of the relationships between diet and cancer through identification of glycosphingolipids as important constituents of food. ..
- Extracellular matrix in chloracetanilide carcinogenesisMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- LC-MS/MS Methods for Analysis of Hemoglogbin AdductsTimothy Fennell; Fiscal Year: 2004..abstract_text> ..
- Sphingolipid signaling in olfactory mucosaMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- IMMUNOSUPPRESSANT MODULATION OF DRUG METABOLISMLANE BRUNNER; Fiscal Year: 2004..This information will have direct application to transplant patients and give clinicians needed information regarding the relationship between immunosuppressive therapy and the prediction of toxicity. ..
- TRIOXANES FOR CHEMOTHERAPY OF MALARIA AND CANCERGary Posner; Fiscal Year: 2005....
- Phase II UDP-glucuronosyltransferases by PXRWen Xie; Fiscal Year: 2007..These include bilirubin and hormonal homeostasis, drug metabolism, and chemical carcinogenesis. ..
- ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCYMartin Ronis; Fiscal Year: 2006..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
- Meeting: Mechanisms of Cell DeathZahra Zakeri; Fiscal Year: 2004..We expect that this meeting will lead to further publications. ..
- PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONSHershel Raff; Fiscal Year: 2006..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
- ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIETMartin Ronis; Fiscal Year: 2005....
- GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTSCandace Johnson; Fiscal Year: 2009..abstract_text> ..
- PTH (7-34) for Chemotherapy alopecia in Breast CancerMichael Holick; Fiscal Year: 2006..unreadable] [unreadable]..
- THE PHOTOBIOLOGY OF VITAMIN DMichael Holick; Fiscal Year: 2005..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
- ENDOCRINE ROLES OF STEROID 5 ALPHA REDUCTASE ISOZYMESDavid Russell; Fiscal Year: 2003....
- Development of blood lipid biomarkers for Alzheimer's disease progressionMichelle Mielke; Fiscal Year: 2008..A major application would be as a surrogate or secondary outcome measure in clinical trials of emerging therapies for AD. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Effect of Aging & Vitamin D Status on OsteoblastogenesisJulie Glowacki; Fiscal Year: 2008..abstract_text> ..
- Enzymes of Skin Lipid MetabolismDavid Russell; Fiscal Year: 2009..The research is relevant to skin disease, dry eye syndrome, and cholesterol metabolism. ..