steroid hydroxylases

Summary

Summary: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.

Top Publications

  1. ncbi Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation
    N Harada
    Proc Natl Acad Sci U S A 82:2024-8. 1985
  2. ncbi Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone
    K A Rose
    Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom
    Proc Natl Acad Sci U S A 94:4925-30. 1997
  3. ncbi Vitamin D: more than a "bone-a-fide" hormone
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Endocrinol 17:777-91. 2003
  4. ncbi Determinants of circulating 1,25-dihydroxyvitamin D3 levels: the role of renal synthesis and catabolism of vitamin D
    Paul H Anderson
    Endocrine Bone Laboratory, Hanson Institute, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 89:111-3. 2004
  5. ncbi Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
    Binbin Wang
    Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Lett 369:104-7. 2004
  6. ncbi Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
    Lionel Bretillon
    Eye and Nutrition Research Group, UMR 1129 FLAVIC, INRA, ENESAD, University of Burgundy, Dijon, France, and Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Eye Res 32:361-6. 2007
  7. ncbi In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg Germany
    Cancer Biol Ther 6:48-55. 2007
  8. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
  9. ncbi Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation
    Sheng Chen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1634-47. 2007
  10. ncbi Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009

Research Grants

  1. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2002
  2. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2002
  3. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2009
  4. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
  5. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
  6. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
  7. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2007
  8. MECHANISMS OF GENE SELECTIVITY IN VITAMIN D SIGNALING
    J Pike; Fiscal Year: 2001
  9. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2002
  10. ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATION
    J Pike; Fiscal Year: 2003

Detail Information

Publications207 found, 100 shown here

  1. ncbi Sex-dependent expression of mouse testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha): cDNA cloning and pretranslational regulation
    N Harada
    Proc Natl Acad Sci U S A 82:2024-8. 1985
    ..Thus, the predominant expression of testosterone 16 alpha-hydroxylase in male 129/J mice is regulated pretranslationally, presumably at the transcriptional level of the P-450(16) alpha gene...
  2. ncbi Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone
    K A Rose
    Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom
    Proc Natl Acad Sci U S A 94:4925-30. 1997
    ..We conclude that Cyp7b is a 7alpha-hydroxylase participating in the synthesis, in brain, of neurosteroids 7alpha-hydroxy DHEA, and 7alpha-hydroxy pregnenolone...
  3. ncbi Vitamin D: more than a "bone-a-fide" hormone
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Endocrinol 17:777-91. 2003
    ....
  4. ncbi Determinants of circulating 1,25-dihydroxyvitamin D3 levels: the role of renal synthesis and catabolism of vitamin D
    Paul H Anderson
    Endocrine Bone Laboratory, Hanson Institute, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 89:111-3. 2004
    ..89, P < 0.001). These findings suggest that kidney CYP24 activity acts in concert with kidney CYP27B1 to control serum 1,25D levels and that serum 1,25D stimulates renal CYP24 expression by acting through the renal VDR...
  5. ncbi Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
    Binbin Wang
    Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Lett 369:104-7. 2004
    ..32, P < 0.001). Our data reveal that the polymorphism of CYP46 intron 2 is implicated in the susceptibility to LOAD and a strong synergistic interaction between CYP46 TT homozoygots and APOE epsilon4 carrier status on the risk of LOAD...
  6. ncbi Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
    Lionel Bretillon
    Eye and Nutrition Research Group, UMR 1129 FLAVIC, INRA, ENESAD, University of Burgundy, Dijon, France, and Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Eye Res 32:361-6. 2007
    ....
  7. ncbi In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg Germany
    Cancer Biol Ther 6:48-55. 2007
    ....
  8. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  9. ncbi Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation
    Sheng Chen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1634-47. 2007
    ..These results indicate that 1,25(OH)(2)D(3) may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders...
  10. ncbi Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  11. ncbi New insights into the mechanisms of vitamin D action
    Sylvia Christakos
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Cell Biochem 88:695-705. 2003
    ..Thus in recent years a number of exciting discoveries have been made that have enhanced our understanding of mechanisms involved in the pleiotropic actions of 1,25(OH)(2)D(3)...
  12. ncbi Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:7711-5. 2004
    ..These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency...
  13. ncbi Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  14. ncbi Selective inhibition of vitamin D hydroxylases in human keratinocytes
    I Schuster
    Novartis Research Institute, Vienna, Austria
    Steroids 66:409-22. 2001
    ..Besides their use as valuable tools in elucidating regulatory mechanisms, inhibitors of VD hydroxylases may give rise to novel therapeutic strategies, especially in defects of cell growth and differentiation...
  15. ncbi Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009
    ..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results...
  16. ncbi Vitamin D metabolism and action in human bone marrow stromal cells
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Endocrinology 151:14-22. 2010
    ....
  17. ncbi Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
    Denise M O Ramirez
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 507:1676-93. 2008
    ..These findings reveal the microsomal localization of 24-hydroxylase and provide subcellular insight into cholesterol turnover in the brain...
  18. ncbi Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    ....
  19. ncbi Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification
    Haiqing Shen
    Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arterioscler Thromb Vasc Biol 30:2648-54. 2010
    ..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
  20. ncbi Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes
    Tara I Ellison
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 282:10953-62. 2007
    ..Cumulatively, these studies support the concept that transactivation by VDR in keratinocytes may be uncoupled from the 1,25(OH)2D3 ligand...
  21. ncbi Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels
    Cynthia Fourgeux
    Eye and Nutrition Research Group, UMR1129 FLAVIC Flaveur, vision et comportement du consommateur Flavor, Vision, and Consumer Behavior, INRA French National Institute for Agricultural Research, Dijon, France
    Invest Ophthalmol Vis Sci 50:5712-7. 2009
    ....
  22. ncbi 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
    Yan Ru Lou
    Department of Anatomy, Medical School, FIN 33014, University of Tampere, Finland
    FASEB J 18:332-4. 2004
    ..Altogether our results suggest that 25OHD3 at a high but physiological concentration acts as an active hormone with respect to vitamin D3 responsive gene regulation and suppression of cell proliferation...
  23. ncbi TNF-alpha interferes with lipid homeostasis and activates acute and proatherogenic processes
    Klementina Fon Tacer
    Center for Functional Genomics and Biochips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
    Physiol Genomics 31:216-27. 2007
    ..Observed acute alterations in lipid metabolism are in agreement with chronic disturbances found in patients...
  24. ncbi Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    I Bjorkhem
    Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Sweden
    J Lipid Res 39:1594-600. 1998
    ..The possibility is discussed that circulating levels of 24S-hydroxycholesterol can be used as a marker for pathological and/or developmental changes in the brain...
  25. ncbi 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells
    Guido Heine
    Allergy Center Charité, CCM, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Immunol 38:2210-8. 2008
    ....
  26. ncbi Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer
    Marjorie L McCullough
    Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA
    Annu Rev Nutr 29:111-32. 2009
    ..Currently, there is no strong, consistent epidemiologic evidence for substantial influences of single variants in vitamin D pathway genes on risk for colorectal, breast, or prostate cancer, but promising leads are developing...
  27. ncbi Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    Kristin K Deeb
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Nat Rev Cancer 7:684-700. 2007
    ..Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents...
  28. ncbi Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  29. ncbi Influence of 1,25-dihydroxy vitamin D3 on TLR4-induced activation of antigen presenting cells is dependent on the order of receptor engagement
    Vandana Gambhir
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    Immunobiology 216:988-96. 2011
    ..Consequently, engagement of VDR by 1,25-(OH)₂D₃ can partially interfere with TLR-4-L-induced activation of pAPCs only when it occurs before TLR-4 stimulation...
  30. ncbi Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
    ..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
  31. ncbi RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells
    P H Anderson
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 103:601-5. 2007
    ....
  32. ncbi CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma
    Guoan Chen
    Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:817-26. 2011
    ..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells...
  33. ncbi No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM)
    Jörg Reichrath
    Department of Dermatology, The Saarland University Hospital, Kirrberger Str, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 89:163-6. 2004
    ..Our results do not support the hypothesis that amplification of 1alpha-OHase or 24-OHase genes may be of importance for pathogenesis or progression of MM...
  34. ncbi Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women
    Tsogzolmaa Dorjgochoo
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Cancer Epidemiol Biomarkers Prev 20:2313-6. 2011
    ..Previous studies evaluating the association of vitamin D-related genetic variants with breast cancer risk have produced inconsistent results...
  35. ncbi Cyp46 polymorphisms in Alzheimer's disease: a review
    Anália Nusya Medeiros Garcia
    Instituto de Ciencias Biologicas, UPE, Recife, Brazil
    J Mol Neurosci 39:342-5. 2009
    ..The aim of this review is to describe and summarize the findings of the researches about the relationship between CYP46 and AD that have been published in the past 9 years...
  36. ncbi Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 350:65-77. 2005
    ....
  37. ncbi Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients
    Y Li
    Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:399-404. 2006
    ..Genetic association of CYP46A1 polymorphisms with AD had been under extensive investigations; however, observations on intron 2 T-->C (rs754203) generated inconclusive results...
  38. ncbi Genetic association of CYP46 and risk for Alzheimer's disease
    Onofre Combarros
    Neurology Service, Marqués de Valdecilla University Hospital University of Cantabria, Santander, Spain
    Dement Geriatr Cogn Disord 18:257-60. 2004
    ..Our results indicate that the intron 2 CYP46 C/C genotype may predispose to AD, and this association is independent of the apolipoprotein E genotype...
  39. ncbi Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
    Jillian Ross
    CXR Biosciences Ltd, 2 James Lindsay Place, Dundee DD1 5JJ, UK
    Toxicol Sci 116:452-66. 2010
    ..However, all parameters investigated to date suggest that much of their functionality is maintained...
  40. ncbi Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
    Valentina Fernández Del Pozo
    Servicio de Neurologia, Hospital Cruces, Barakaldo, Spain
    Dement Geriatr Cogn Disord 21:81-7. 2006
    ....
  41. ncbi CYP46: a risk factor for Alzheimer's disease or a coincidence?
    Ewa Golanska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Neurosci Lett 383:105-8. 2005
    ..However, considering the extreme divergence of results obtained by different authors, a clear connection between the CYP46 gene and AD is questionable...
  42. ncbi The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification
    Frederic Gachon
    Department of Molecular Biology, National Center of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 1211 Geneva 4, Switzerland
    Cell Metab 4:25-36. 2006
    ..Indeed, PAR bZip triple knockout mice are hypersensitive to xenobiotic compounds, and the deficiency in detoxification may contribute to their early aging...
  43. ncbi Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    Y Ikeda
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    Mol Endocrinol 8:654-62. 1994
    ..studied the developmental profile of steroidogenic factor-1 (SF-1), a nuclear receptor that regulates the steroid hydroxylases. SF-1 transcripts first appear on embryonic day 9 (E9) in the urogenital ridge, the probable source of ..
  44. ncbi Expression of VDR and CYP24A1 mRNA in human tumors
    Mark G Anderson
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Cancer Chemother Pharmacol 57:234-40. 2006
    ..These data suggest that the VDR signaling pathway may be compromised via the modulation of CYP24A1 and VDR in human tumors...
  45. ncbi Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators
    Barbara Borroni
    Neurologic Clinic, University of Brescia, Spedali Civili de Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy
    Neurobiol Aging 25:747-51. 2004
    ..02). These findings provide direct evidence that CYP46 and ApoE polymorphisms synergically increase the risk for AD development, and influence on the rate of cognitive decline...
  46. ncbi Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements
    K S Chen
    Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    Biochim Biophys Acta 1263:1-9. 1995
    ..Further characterization of these VDREs in various constructs with either a native or TK promoter suggests that both VDREs are required for the optimal induction of 24-hydroxylase expression by 1,25-(OH)2D3...
  47. ncbi 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Breast Cancer Res 7:R980-6. 2005
    ..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...
  48. ncbi Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis
    K Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Mult Scler 16:133-8. 2010
    ..The finding of a marginally significant gene-environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context...
  49. ncbi Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon
    Damien Matusiak
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street (M/C 716, Chicago, IL 60612, USA
    Cancer Epidemiol Biomarkers Prev 14:2370-6. 2005
    ..Overall, these data support using 25(OH)D3 for colorectal cancer chemoprevention but suggest that pro-vitamin D is less likely to be useful for colorectal cancer chemotherapy...
  50. ncbi Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
    D G Albertson
    1 Cancer Research Institute, University of California, San Francisco, Box 0808, San Francisco, California, USA
    Nat Genet 25:144-6. 2000
    ..The putative oncogene ZNF217 (ref. 5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other...
  51. ncbi Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells
    Susanna Miettinen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:367-73. 2004
    ..The possible mitogenic effects of vitamin D should be considered when evaluating treatment of ovarian cancer with vitamin D...
  52. ncbi Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies
    Lorenza Díaz
    Department of Reproductive Biology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico Distrito Federal, 14000, Mexico
    J Clin Endocrinol Metab 87:3876-82. 2002
    ..These results support the role of placenta as a contributor to the abnormalities observed in calcium metabolism in PE...
  53. ncbi Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta
    John Dulos
    Organon NV, Oss, The Netherlands
    Arthritis Rheum 50:3346-53. 2004
    ..This study was undertaken to investigate the putative role of CYP7B in arthritis using murine collagen-induced arthritis (CIA), an interleukin-1beta (IL-1beta)-dependent model...
  54. ncbi Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, California 94305-5118, USA
    J Urol 168:1583-8. 2002
    ....
  55. ncbi Development of a vitamin D-responsive organ culture system for adult and old rat intestine
    H J Armbrecht
    Geriatric Research, Education, and Clinical Center, St. Louis VA Medical Center, St. Louis, Missouri 63125, USA
    Dig Dis Sci 47:2831-8. 2002
    ..Since the 24-hydroxylase is the first step in the degradative pathway for 1,25(OH)2D in the intestine, increased duodenal expression of the 24-hydroxylase may contribute to the decreased action of 1,25(OH)2D on the adult duodenum...
  56. ncbi Steroid and sterol 7-hydroxylation: ancient pathways
    Richard Lathe
    Division of Biomedical Sciences, University of Edinburgh, George Square, EH9 9XD, Edinburgh, UK
    Steroids 67:967-77. 2002
    ..Early receptor targets probably included intracellular sterol sites, some modern steroids may continue to act at these targets. 7-Hydroxylation of DHEA may reflect conservation of an early signaling pathway...
  57. ncbi The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:36987-90. 2002
    ..We believe this to be a unique mechanism for autoregulation of steroid hormone synthesis...
  58. ncbi Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  59. ncbi Gene regulatory potential of nonsteroidal vitamin D receptor ligands
    MIKAEL PERAKYLA
    Department of Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Endocrinol 19:2060-73. 2005
    ..At a noncalcemic dose of 150 microg/kg, CD4528 showed in vivo a clear induction of CYP24 expression and therefore may be used as a lead compound for the development of therapeutics against psoriasis, osteoporosis, and cancer...
  60. ncbi Autocrine metabolism of vitamin D in normal and malignant breast tissue
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham, Birmingham, United Kingdom
    Clin Cancer Res 11:3579-86. 2005
    ..The enzymes involved in autocrine metabolism of vitamin D in breast tissue may therefore provide important targets for both the prevention and treatment of breast cancer...
  61. ncbi The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:1447-61. 2006
    ..These studies identify a mechanism by which 1,25-(OH)2D3 regulates the expression of TRPV6 in human intestinal cells...
  62. ncbi The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    P Wei
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 407:920-3. 2000
    ..Thus, loss of CAR function alters sensitivity to toxins, increasing or decreasing it depending on the compound. Modulation of CAR activity in humans may significantly affect metabolism of drugs and other xenobiotics...
  63. ncbi Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene
    Katsuhisa Tashiro
    Molecular Biology Laboratory, Department of Life and Environmental Sciences, Prefectural University of Hiroshima, 562 Nanatsuka, Shobara, Hiroshima 727 0023, Japan
    Biochem Biophys Res Commun 358:259-65. 2007
    ..Further upstream sequence and the 5'-untranslated region did not appear to play a major role in the vitamin D response...
  64. ncbi Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2
    Min Cui
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47906 2059, USA
    J Cell Physiol 219:132-42. 2009
    ..Our data show that there are both promoter-specific and cell stage-specific roles for the ERK signaling pathway on 1,25(OH)(2)D(3)-mediated gene induction in enterocyte-like Caco-2 cells...
  65. ncbi 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression
    P Bareis
    Department of Pathophysiology, University of Vienna Medical School, Vienna, A-1090, Austria
    Biochem Biophys Res Commun 285:1012-7. 2001
    ....
  66. ncbi Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  67. ncbi Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction
    P P Dwivedi
    Department of Biochemistry, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 275:47-55. 2000
    ..A fundamental role was established for transcriptional cooperation between Ras-activated Ets proteins and the VDR.RXR complex in mediating 1, 25-(OH)(2)D(3) action on the CYP24 promoter...
  68. ncbi CYP27A1 and CYP24 expression as a function of malignant transformation in the colon
    Damien Matusiak
    Department of Medicine, University of Illinois at Chicago, 840 S Wood St M C 716, Chicago, IL 60612, USA
    J Histochem Cytochem 55:1257-64. 2007
    ..These data indicate that non-toxic vitamin D precursors should be sufficient for CRC chemoprevention, but that neither vitamin D nor its precursors may be sufficient for CRC chemotherapy...
  69. ncbi Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    Z Wu
    Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, P O Box 95, Rootstown, OH 44272, USA
    J Lipid Res 40:2195-203. 1999
    ..Transient transfection assays of CYP7B1 promoter/luciferase reporter constructs in HepG2 cells revealed that the promoter was highly active. The 5' upstream region from nt -83 to +189 is the core promoter of the gene...
  70. ncbi 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin
    X Y Li
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Endocrinol 13:1686-94. 1999
    ..D3 exerts dual positive influences on its nuclear receptor, simultaneously stimulating VDR transactivation activity and retarding VDR degradation...
  71. ncbi 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis
    H S Cross
    Department of Pathophysiology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Steroids 66:287-92. 2001
    ....
  72. ncbi Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts
    Euclides Avila
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico D F, Mexico
    J Steroid Biochem Mol Biol 103:90-6. 2007
    ..The overall data suggest that calcitriol downregulates CYP27B1 expression via a cAMP-dependent signaling pathway, whereas upregulates 24-hydroxylase gene expression through a VDR-dependent mechanism...
  73. ncbi Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression
    R Ahlgren
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 265:3313-9. 1990
    ..Whether or not there are sequences conferring cAMP responsiveness which are common both to P-450scc and the other steroidogenic P-450 genes remains to be established...
  74. ncbi 25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer
    Eduardo Carneiro de Lyra
    , , , Brazil
    J Steroid Biochem Mol Biol 100:184-92. 2006
    ..A low 1,25(OH)2D3 serum concentration seems to be associated to breast cancer, however, the mechanism involved in this regulation is still unclear...
  75. ncbi Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Biol Reprod 75:816-22. 2006
    ....
  76. ncbi Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis
    C M Hansen
    Department of Biochemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    Front Biosci 6:D820-48. 2001
    ..The present review will focus on the results obtained in these studies and describe some of the synthetic analogs, which have shown to be of particular interest in relation to cancer...
  77. ncbi Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b
    Sayaka Komagata
    Drug Metabolism and Toxicology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Mol Pharmacol 76:702-9. 2009
    ..In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24, which serves as a possible mechanism for the high CYP24 expression in cancer tissues...
  78. ncbi 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes
    Yohan Bosse
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 29:161-8. 2007
    ..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
  79. ncbi Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
    Ivy Chung
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 282:8704-14. 2007
    ....
  80. ncbi Inhibitors of vitamin D hydroxylases: structure-activity relationships
    Inge Schuster
    Institute of Pharmaceutical Chemistry, University Vienna, Althanstrasse 15, A-1090 Wien, Osterreich
    J Cell Biochem 88:372-80. 2003
    ..In the absence of crystal structures, our inhibitors are valuable tools to model and understand the active sites of vitamin D hydroxylases, resulting in the design of powerful, selective therapeutics...
  81. ncbi Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase
    H Postlind
    Department of Pharmaceutical Biosciences, University of Uppsala, Sweden
    Biochem Biophys Res Commun 241:491-7. 1997
    ..Northern blot analysis showed that the mRNA for vitamin D3 25-hydroxylase is found in liver and kidney...
  82. ncbi Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
    Endocrinology 146:825-34. 2005
    ..These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis...
  83. ncbi CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines
    John Dulos
    University Medical Center Utrecht, The Netherlands
    Arthritis Rheum 52:770-8. 2005
    ..The purpose of this study was to investigate the presence of 7alpha-OH-DHEA in synovial samples and the cytokine regulation of CYP7B activity in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
  84. ncbi Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
    Matthias Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
    Respir Res 7:60. 2006
    ....
  85. ncbi Eight cytochrome P450s catalyze vitamin D metabolism
    Yoshihiko Ohyama
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Front Biosci 9:3007-18. 2004
    ..The main focus of this review is to summarize the properties of individual P450 in light of their catalytic activities to understand their physiological significance...
  86. ncbi Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3)
    Petra Bareis
    Department of Pathophysiology, University of Vienna Medical School, Austria
    Exp Cell Res 276:320-7. 2002
    ....
  87. ncbi Characterization of Phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch)
    Aline Y O Matsuo
    Department of Environmental Sciences, University of California, Riverside, CA 92521, USA
    Comp Biochem Physiol C Toxicol Pharmacol 147:78-84. 2008
    ....
  88. ncbi Correlation between alterations in nucleosomal organization of LINEs in the promoter of cytochrome P450 2B1/2 gene and induction of CYP 2B1/2B2 mRNA expression by phenobarbitone in rat liver
    Indranil Dey
    Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    DNA Cell Biol 24:359-70. 2005
    ..This might be a novel function of LINEs in the mammalian genome that correlates the chromatin structure with gene expression during drug metabolism...
  89. ncbi Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats
    Yang Xu
    Department of Pharmaceutics, University of Washington, Seattle, 98195-7610, USA
    Biochem Pharmacol 72:385-92. 2006
    ....
  90. ncbi Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet
    Kouichi Yoshinari
    Department of Pharmaco Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Pharm Res 23:1188-200. 2006
    ..In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice...
  91. ncbi Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats
    Ravindra N Dhir
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104-6048, USA
    Proc Natl Acad Sci U S A 100:15224-8. 2003
    ....
  92. ncbi Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes
    Matthew A Cerny
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA
    Arch Biochem Biophys 436:265-75. 2005
    ....
  93. ncbi Purification and characterization of a vitamin D3 25-hydroxylase from pig liver microsomes
    E Axen
    Department of Pharmaceutical Biochemistry, University of Uppsala, Sweden
    Biochem J 287:725-31. 1992
    ..The results of the present study show that the pig appears to be a representative species for evaluation of vitamin D3 hydroxylases in other mammals, including man...
  94. ncbi Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon
    G Sun
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Xenobiotica 37:180-93. 2007
    ..Triadimefon also increased CYP3A2 immunoreactive protein levels 1.8-fold. These results indicate that triadimefon and myclobutanil, like other triazole-containing conazoles, induced CYP2B and CYP3A families of cytochromes in rat liver...
  95. ncbi The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats
    Timothy R Fennell
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:7-13. 2004
    ..Cytochrome P450 2E1 appears to be the major isoform of cytochrome P450 inhibited by exposure to ethylene, and this may explain in part the observed alteration in EO blood kinetics...
  96. ncbi Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
    Mehrdad Rahmaniyan
    Department of Medicine, Medical University of South Carolina, Strom Thurmond Research Building, Charleston, SC 29425, USA
    Am J Physiol Endocrinol Metab 288:E753-60. 2005
    ..It is concluded that CYP2C11 is a male-specific hepatic microsomal vitamin D 25-hydroxylase that hydroxylates vitamin D2, vitamin D3, 1alphaOHD2, and 1alphaOHD3. CYP2C11 is also a vitamin D 24-hydroxylase...
  97. ncbi Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats
    Daniel R Parkin
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Food Chem Toxicol 46:2451-8. 2008
    ....
  98. ncbi Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels
    Paul H Anderson
    Endocrine Bone Research Laboratory, Hanson Institute, Adelaide, SA, Australia
    Bone 36:654-62. 2005
    ..The synthesis of 1,25D in bone tissue regulates bone CYP24 expression and is associated with bone mineralization suggesting that vitamin D metabolism has an autocrine or paracrine function...
  99. ncbi Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 22:367-76. 2007
    ..Thus, CYP2C11/13 could associate with UGTs, but the affinity is assumed to be weaker than that of CYP2B/3As. These results suggest that there is isoform specificity in the interaction between P450s and UGTs...
  100. ncbi Spurious observation of splenic cyp2b1 expression
    Meena R Sharma
    Laboratories of Biochemistry, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6048, USA
    Drug Metab Dispos 31:1074-6. 2003
    ....
  101. ncbi Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium
    Kevin D Healy
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:9733-7. 2003
    ..This in vivo study demonstrates that 1,25(OH)2D3 and calcium are both required for renal VDR mRNA expression above a basal level, furthering our understanding of the complex regulation of renal VDR by 1,25(OH)2D3 and calcium...

Research Grants141 found, 100 shown here

  1. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2002
    ..This process is mediated by cAMP exerting transcriptional pressure on genes encoding adrenocortical steroid hydroxylases (P450s) and related proteins...
  2. SF1--KEY MEDIATOR OF ENDOCRINE DEVELOPMENT AND FUNCTION
    Keith Parker; Fiscal Year: 2002
    ..nuclear receptor steroidogenic factor1 (SF-1), originally isolated as a regulator of the cytochrome P450 steroid hydroxylases, plays essential roles in endocrine development and function...
  3. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2009
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  4. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  5. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..These funds will aid immensely in allowing AIMM to fulfill its function to stimulate further creativity in bone and cartilage research and to provide young investigators with a tribune to promote their talent. ..
  6. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  7. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2007
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  8. MECHANISMS OF GENE SELECTIVITY IN VITAMIN D SIGNALING
    J Pike; Fiscal Year: 2001
    ....
  9. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2002
    ..These determinants may be exploited together with novel vitamin D analogues in the treatment of bone diseases exemplified by osteoporosis and hypeproliferative diseases such as psoriasis and cancer. ..
  10. ESTROGENS AND OSTEOCLAST RECRUITMENT AND DIFFERENTIATION
    J Pike; Fiscal Year: 2003
    ..As in Specific Aim 1, the activity of SERMs in osteoclast differentiation will be evaluated. ..
  11. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Pike; Fiscal Year: 2007
    ..abstract_text> ..
  12. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2009
    ..The studies herein seek to identify the mechanisms that underlie the expression of this factor such that better and more selective medicines can be created. ..
  13. Vitamin D Ligands and Regulation of Calcium Homeostasis
    J Wesley Pike; Fiscal Year: 2010
    ..These concepts will enable more rationale approaches to the design and synthesis of therapeutically relevant vitamin D analogues. ..
  14. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Wesley Pike; Fiscal Year: 2010
    ..The studies herein seek to determine the mechanisms that control expression of the vitamin D receptor in tissues such that better and more selective medicines can be created. ..
  15. Molecular Mechanisms of RANKL Activation in Osteoblasts
    J Pike; Fiscal Year: 2007
    ..These studies will provide important detail into the mechanism by which calciotropic hormones and cytokines regulate RANKL expression, a gene whose product is central to bone resorption. ..
  16. BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENE
    J Pike; Fiscal Year: 2009
    ..The studies herein seek to determine the mechanisms that control expression of the vitamin D receptor in tissues such that better and more selective medicines can be created. ..
  17. Significance of CYP46A1 and other P450s in retinal function
    Irina Pikuleva; Fiscal Year: 2007
    ..Relevance (for lay audience). This research will be critical for understanding the development of certain eye diseases that reduce vision. ..
  18. Cholesterol-metabolizing P450s and Alzheimer's disease
    Irina Pikuleva; Fiscal Year: 2007
    ..If funded, the release time and salary support will significantly enhance the P.I.'s career in basic science research and make it more medically oriented. ..
  19. CA++ BINDING PROTEINS AND THE VITAMIN D ENDOCRINE SYSTEM
    Sylvia Christakos; Fiscal Year: 1993
    ....
  20. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2009
    ....
  21. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  22. CA++ BINDING PROTEINS AND THE VITAMIN D ENDOCRINE SYSTEM
    Sylvia Christakos; Fiscal Year: 1991
    ..Additionally, this study may lead to an increased understanding of the role of the vitamin D endocrine system in normal brain function as well as in brain disorder involving calcium dependent functions...
  23. Vitamin D Hormone: Function and Mechanism of Action
    Sylvia Christakos; Fiscal Year: 2007
    ..abstract_text> ..
  24. Comparison of CYP2 Genes Across Mammal Species
    Susan Hoffman; Fiscal Year: 2004
    ..abstract_text> ..
  25. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  26. Colon-specific Transgenic Mouse for Cancer Research
    JAMES FLEET; Fiscal Year: 2007
    ..In addition, colon cancer models made with the new transgenic mouse will be useful for testing agents for their ability to treat and prevent cancer. ..
  27. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2007
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  28. Vitamin D Status and Prostate Cancer
    JAMES FLEET; Fiscal Year: 2007
    ..These data will provide us with the mechanistic basis for dietary recommendations to prevent prostate cancer and optimize bone health. ..
  29. The Interaction Between Hepatic Insulin Resistance and Cholesterol Metabolism
    Sudha Biddinger; Fiscal Year: 2007
    ..C. Ronald Kahn, and be well positioned to make significant scientific and medical contributions to the understanding of insulin resistance in children and adolescents. ..
  30. Intestinal calcium absorption: molecular mechanisms
    JAMES FLEET; Fiscal Year: 2007
    ..g. when vitamin D resistance associated with aging or estrogen deficiency is present. ..
  31. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2007
    ..Since estrogens are prerequisites for breast cancer, delineating the regulatory effects of LXRs on EST/SULT1E1 expression may have a broader significance in the understanding of breast cancer prevention and treatment. ..
  32. Cytochrome P450 in Nicotine Metabolism
    Sharon Murphy; Fiscal Year: 2004
    ....