viper venoms

Summary

Summary: Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.

Top Publications

  1. ncbi Crotalid envenomation: the southern Arizona experience
    J T Tokish
    Sections of Orthopedic Surgery, The University of Arizona Health Sciences Center, Tucson, USA
    J Orthop Trauma 15:5-9. 2001
  2. ncbi Unusual neurotoxic envenomations by Vipera aspis aspis snakes in France
    L de Haro
    Centre Anti Poisons, Hĵpital Salvator, Marseille, France
    Hum Exp Toxicol 21:137-45. 2002
  3. ncbi Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina
    Amine Bazaa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Proteomics 5:4223-35. 2005
  4. ncbi Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin
    C Marcinkiewicz
    Sol Sherry Thrombosis Research Center, Department of Pharmacology, and Department of Physiology, Temple University, School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 39:9859-67. 2000
  5. ncbi Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor
    Ching Hu Chung
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Blood 103:2105-13. 2004
  6. pmc Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution
    Axel Barlow
    School of Biological Sciences, Environment Centre Wales, Bangor University, Bangor LL57 2UW, UK
    Proc Biol Sci 276:2443-9. 2009
  7. pmc Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts
    Nicholas R Casewell
    School of Biological Sciences, Bangor University, Environment Centre Wales, Bangor, UK
    BMC Genomics 10:564. 2009
  8. ncbi Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
  9. ncbi Heterodimeric neurotoxic phospholipases A2--the first proteins from venom of recently established species Vipera nikolskii: implication of venom composition in viper systematics
    Anna S Ramazanova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow 117997, Russian Federation
    Toxicon 51:524-37. 2008
  10. ncbi The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles
    Bruno Lomonte
    Instituto Clodomiro Picado, School of Microbiology, Universidad de Costa Rica, San Jose, Costa Rica
    Protein Pept Lett 16:860-76. 2009

Detail Information

Publications208 found, 100 shown here

  1. ncbi Crotalid envenomation: the southern Arizona experience
    J T Tokish
    Sections of Orthopedic Surgery, The University of Arizona Health Sciences Center, Tucson, USA
    J Orthop Trauma 15:5-9. 2001
    ..They recommend that established objective envenomation severity scores be used to dictate patient treatment, specifically the use of antivenin...
  2. ncbi Unusual neurotoxic envenomations by Vipera aspis aspis snakes in France
    L de Haro
    Centre Anti Poisons, Hĵpital Salvator, Marseille, France
    Hum Exp Toxicol 21:137-45. 2002
    ..The existence of geographical variations in the composition of V.a.a. venom emphasizes on the use of polyvalent antivenom in the treatment of viper envenomations in France...
  3. ncbi Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina
    Amine Bazaa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Proteomics 5:4223-35. 2005
    ....
  4. ncbi Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin
    C Marcinkiewicz
    Sol Sherry Thrombosis Research Center, Department of Pharmacology, and Department of Physiology, Temple University, School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 39:9859-67. 2000
    ..In addition, EMS16 inhibits HUVEC migration in collagen I gel. In conclusion, we report a new, potent viper venom-derived inhibitor of alpha2beta1 integrin, which does not belong to the disintegrin family...
  5. ncbi Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor
    Ching Hu Chung
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Blood 103:2105-13. 2004
    ....
  6. pmc Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution
    Axel Barlow
    School of Biological Sciences, Environment Centre Wales, Bangor University, Bangor LL57 2UW, UK
    Proc Biol Sci 276:2443-9. 2009
    ....
  7. pmc Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts
    Nicholas R Casewell
    School of Biological Sciences, Bangor University, Environment Centre Wales, Bangor, UK
    BMC Genomics 10:564. 2009
    ..We adopt a venom gland transcriptome approach in order to investigate the diversity of toxins in the genus and elucidate the mechanisms which result in prey-specific adaptations of venom composition...
  8. ncbi Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  9. ncbi Heterodimeric neurotoxic phospholipases A2--the first proteins from venom of recently established species Vipera nikolskii: implication of venom composition in viper systematics
    Anna S Ramazanova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow 117997, Russian Federation
    Toxicon 51:524-37. 2008
    ..nikolskii and V. ammodytes) corroborates the hypothesis about the pre-existence of genes encoding these proteins in all true viper species and their expression under certain conditions...
  10. ncbi The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles
    Bruno Lomonte
    Instituto Clodomiro Picado, School of Microbiology, Universidad de Costa Rica, San Jose, Costa Rica
    Protein Pept Lett 16:860-76. 2009
    ..Finally, experiments designed to assess the validity of such hypothetical roles are suggested, to stimulate future studies in this field...
  11. pmc Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros
    Sakthivel Vaiyapuri
    Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom
    PLoS ONE 6:e21532. 2011
    ....
  12. ncbi Effect of VP12 and viperistatin on inhibition of collagen-receptor-dependent melanoma metastasis
    Izabela Staniszewska
    Department of Biology, Temple University, College of Science and Technology, Philadelphia, PA 19122, USA
    Cancer Biol Ther 8:1507-16. 2009
    ..These data suggest that collagen receptors may be an interesting target for development of new anti-metastatic therapies...
  13. doi MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration
    Amine Bazaa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur Belvedère BP74, Tunis, Tunisia
    Matrix Biol 28:188-93. 2009
    ..This finding may serve as starting point for structure-function relationship studies leading to design a new generation of specific anti-cancer drugs...
  14. ncbi Restoration of enzymatic activity in a Ser-49 phospholipase A2 homologue decreases its Ca(2+)-independent membrane-damaging activity and increases its toxicity
    Toni Petan
    Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochemistry 46:12795-809. 2007
    ....
  15. doi Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration
    Raoudha Zouari-Kessentini
    Laboramtoire des Venins et Toxines, Institut Pasteur de Tunis, 13 Place Pasteur, BP 74, 1002 Tunis Belvedere, Tunisia
    Toxicon 53:444-53. 2009
    ..Furthermore, both CC-PLA2-1 and CC-PLA2-2 abolished HT1080 cell migration towards fibrinogen and fibronectin. This activity is reported for the first time for PLA2 enzymes...
  16. pmc Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
    Sakthivel Vaiyapuri
    School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom
    PLoS Negl Trop Dis 4:e796. 2010
    ....
  17. doi Characterization of a new polyvalent antivenom (Antivipmyn Africa) against African vipers and elapids
    Blanca Ramos-Cerrillo
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Av Universidad 2001, Cuernavaca, Morelos 62210, Mexico
    Toxicon 52:881-8. 2008
    ..The criteria for its design are discussed, particularly in terms of the implementation of realistic public health policies targeting mostly rural populations in the continent...
  18. pmc Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2
    Aleksandra A Watson
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    Protein Sci 17:1611-6. 2008
    ....
  19. pmc Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling
    Sonia Severin
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 286:4107-16. 2011
    ....
  20. doi An unusual phospholipase A₂ from puff adder Bitis arietans venom--a novel blocker of nicotinic acetylcholine receptors
    Catherine A Vulfius
    Institute of Cell Biophysics, Russian Academy of Sciences, ul Institutskaya 3, Pushchino, Moscow Region 142290, Russia
    Toxicon 57:787-93. 2011
    ..Indeed, the protein possessed high PLA₂ activity, which was 1.95 mmol/min/μmol. Bitanarin is the first described PLA₂ that contains 14 disulphide bonds and the first nAChR blocker possessing PLA₂ activity...
  21. ncbi Multiple thrombotic occlusions of vessels after Russell's viper envenoming
    Dong Zong Hung
    Institute of Toxicology, National Taiwan University, Taipei, Taiwan
    Pharmacol Toxicol 91:106-10. 2002
    ....
  22. ncbi Ventricular tachycardia, a rare manifestation of Russell's viper bite: case report
    Yotsapon Thewjitcharoen
    Chaophya Abhaibhubejhr Hospital, 32 7 Moo 12 Prachianusorn Rd, Ampur Muang, Prachinburi 25000, Thailand
    J Med Assoc Thai 88:1931-3. 2005
    ..He was successfully treated by cardiovertion and amiodarone. Subsequently, antivenom for Russell's Viper was administered for correction of a bleeding disorder..
  23. ncbi Cloning and expression of an acidic platelet aggregation inhibitor phospholipase A2 cDNA from Bothrops jararacussu venom gland
    Patrícia G Roberto
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, UNAERP, Ribeirao Preto, SP, Brazil
    Protein Expr Purif 37:102-8. 2004
    ..The structure and function of the recombinant protein was compared to that of the native protein by circular dichroism (CD), enzymatic activity, edema-inducing, and platelet aggregation inhibition activities...
  24. ncbi Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography
    Danielle Ianzer
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, Av Vital Brasil, 1500, Sao Paulo, SP 05503 900
    Peptides 25:1085-92. 2004
    ..Besides the amino acid sequence homology, the corresponding synthetic peptides were able to potentiate bradykinin on the isolated guinea-pig ileum...
  25. pmc Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth
    MEGHAN C BROWN
    Department of Neuroscience, Center for Neurovirology and Cancer Biology, Temple University, School of Medicine, Philadelphia, PA, USA
    Int J Cancer 123:2195-203. 2008
    ..Summarizing, we present studies of low molecular weight disintegrin, obtustatin as a potential therapeutic compound for treatment of melanoma that contain a high level of vascularization...
  26. ncbi Factor X activator from Vipera lebetina venom is synthesized from different genes
    Ene Siigur
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Biochim Biophys Acta 1702:41-51. 2004
    ..These are the first cloned factor X activator heavy and light chains. We demonstrate that the heavy and light chains are synthesized from different genes...
  27. doi Cysteine-rich venom proteins from the snakes of Viperinae subfamily - molecular cloning and phylogenetic relationship
    Anna S Ramazanova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Laboratory of Neuropeptide Receptors, ul Miklukho Maklaya 16 10, Moscow 117997, Russia
    Toxicon 53:162-8. 2009
    ..berus venom was revealed using a combination of gel-filtration chromatography, electrophoresis and MALDI mass spectrometry. The finding of the putative channel blocker in viper venom may indicate its action on prey nervous system...
  28. pmc Expression and characterization of recombinant ecarin
    Anna Jonebring
    AstraZeneca R and D, 43183, Molndal, Sweden
    Protein J 31:353-8. 2012
    ..9 μM. In conclusion, r-ecarin was identified as a promising candidate for replacement of native ecarin in assays utilizing conversion of prothrombin to thrombin...
  29. pmc Saw-scaled viper bites in Sri Lanka: is it a different subspecies? Clinical evidence from an authenticated case series
    Ariaranee Gnanathasan
    Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka
    Am J Trop Med Hyg 86:254-7. 2012
    ....
  30. pmc Pharmacological aspects of Vipera xantina palestinae venom
    Tatjana Momić
    School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Toxins (Basel) 3:1420-32. 2011
    ..These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation...
  31. doi Revisiting saw-scaled viper (Echis carinatus) bites in the Jaffna Peninsula of Sri Lanka: distribution, epidemiology and clinical manifestations
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka
    Trans R Soc Trop Med Hyg 105:591-7. 2011
    ..The median time for correction of coagulopathy was 802min (range 180-1669min) with Indian polyvalent antivenom. All recovered. The saw scaled viper is responsible for most venomous bites in the Jaffna peninsula...
  32. doi Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biochem 150:127-32. 2011
    ..The absence of CLEC-2 does not significantly increase bleeding tendency, implying that CLEC-2 may be a good target protein for anti-platelet drugs in addition to anti-metastatic drugs...
  33. ncbi A [Lys⁴⁹]phospholipase A₂ from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma-membrane rupture in human leukemia cells
    Tatsuo Murakami
    Department of Applied Life Science, Faculty of Bioscience and Biotechnology, Sojo University, Kumamoto, Japan
    Biosci Biotechnol Biochem 75:864-70. 2011
    ..In the cells treated with BPII, this spread over the cell membranes, implying that the cell toxicity of BPII is mediated via its cell-surface receptor...
  34. doi cDNA cloning, structural, and functional analyses of venom phospholipases A₂ and a Kunitz-type protease inhibitor from steppe viper Vipera ursinii renardi
    Inn Ho Tsai
    Institute of Biological Chemistry, Academia Sinica, P O Box 23 106, Taipei, Taiwan
    Toxicon 57:332-41. 2011
    ..Vur-PL2B was weakly cytotoxic to rat pheochromocytoma PC12 cells and showed both strong anticoagulant and anti-platelet activities. This is the first case of a strong anticoagulating ammodytin I analog in Vipera venom...
  35. doi A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation
    C H Chang
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Thromb Haemost 8:2563-70. 2010
    ..Snake venom C-type lectin proteins (snaclecs) have diverse targets, including platelet GPVI, GPIb, integrin α2β1 or CLEC-2 expressed in platelets, endothelial cells or myeloid cells...
  36. doi Identification and characterization of a phospholipase A2 from the venom of the Saw-scaled viper: Novel bactericidal and membrane damaging activities
    Ramar Perumal Samy
    Venom and Toxin Research Programm, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Biochimie 92:1854-66. 2010
    ..In conclusion, EcTx-I displays a heparin binding C-terminal region, which is probably responsible for the cytotoxic and bactericidal effects...
  37. pmc Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros
    Sakthivel Vaiyapuri
    School of Biological Sciences, University of Reading, Reading, United Kingdom
    PLoS ONE 5:e9687. 2010
    Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims...
  38. doi Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A(2) from the snake venom of Vipera lebetina (Levantine viper)
    Heiki Vija
    National Institute of Chemical Physics and Biophysics, Laboratory of Bioorganic Chemistry, Akadeemia tee 23, Tallinn 12618, Estonia
    Toxicon 54:429-39. 2009
    ..The phylogenetic analysis on the basis of the amino acid sequence homology demonstrates that VLPLA(2)s grouped with other Asp49 PLA(2)s and they appear to share a close evolutionary relationship with the European vipers...
  39. ncbi Lebecetin, a potent antiplatelet C-type lectin from Macrovipera lebetina venom
    Sameh Sarray
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, 1002 Belvédère, Tunis, Tunisia
    Biochim Biophys Acta 1651:30-40. 2003
    ..These observations suggest that lebecetin is a C-type lectin-like protein that selectively binds to platelet GPIb...
  40. ncbi Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom
    J Siigur
    Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    Thromb Res 90:39-49. 1998
    ..Vipera lebetina venom from a single snake contains mainly one form of lebetase. Lebetase I is more stable at low pH than lebetase II. The lebetases I and II inhibit platelet aggregation induced by ADP in a dose-dependent manner...
  41. pmc Accelerated exchange of exon segments in Viperid three-finger toxin genes (Sistrurus catenatus edwardsii; Desert Massasauga)
    Robin Doley
    Protein Science Laboratory, Department of Biological Sciences, National University of Singapore, 117543, Singapore
    BMC Evol Biol 8:196. 2008
    ..Venom proteins are encoded by multigene families that have evolved through a process of gene duplication followed by accelerated evolution in the protein coding region...
  42. ncbi Anticoagulant serine fibrinogenases from Vipera lebetina venom: structure-function relationships
    Ene Siigur
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Thromb Haemost 89:826-31. 2003
    ..Until now there is no evidence of the anticoagulant serine enzymes degrading fibrinogen alpha-chain only and lacking esterolytic activity...
  43. ncbi Purification and characterization of a phospholipase A2 isoenzyme isolated from Lachesis muta snake venom
    André L Fuly
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, RJ, Rio de Janeiro, Brazil
    Biochem Pharmacol 63:1589-97. 2002
    ..Pretreatment of LM-PLA2-II with p-bromophenacyl bromide abolished all of these actions, clearly indicating that the biological activities, including the edematogenic effect, are dependent entirely on its enzymatic activity...
  44. ncbi Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat
    Marie Henriksson
    Division of Experimental Vascular Research, Lund University Hospital, Wallenberg Neurocentrum, BMC A13, 221 84 Lund, Sweden
    Stroke 34:1479-83. 2003
    ..The aim of this study was to examine the upregulation of contractile ETB receptors in cerebral arteries after organ culture and to elucidate the intracellular pathways involved...
  45. doi The platelet receptor CLEC-2 is active as a dimer
    Aleksandra A Watson
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochemistry 48:10988-96. 2009
    ....
  46. ncbi The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2
    Aleksandra A Watson
    Henry Wellcome Building for Molecular Physiology, Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Biol Chem 282:3165-72. 2007
    ....
  47. ncbi Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    J Biol Chem 282:25993-6001. 2007
    ..These findings suggest that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplanin...
  48. pmc Randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (Echis ocellatus) envenoming in Nigeria
    Isa S Abubakar
    Department of Community Medicine, Bayero University of Kano, Kano, Nigeria
    PLoS Negl Trop Dis 4:e767. 2010
    ..In West Africa, envenoming by saw-scaled or carpet vipers (Echis ocellatus) causes great morbidity and mortality, but there is a crisis in supply of effective and affordable antivenom (ISRCTN01257358)...
  49. ncbi Nucleotidase and DNase activities in Brazilian snake venoms
    Paulo Bruno Valadão Sales
    Laboratory of Pathophysiology, Institute Butantan, Brazil
    Comp Biochem Physiol C Toxicol Pharmacol 147:85-95. 2008
    ..The omnipresence of nucleotidase and DNase activities in viperid venoms implies a role for them within the repertoire of enzymes involved in immobilization and death of preys...
  50. doi Structural requirements of KTS-disintegrins for inhibition of alpha(1)beta(1) integrin
    MEGHAN C BROWN
    Department of Biology, Center for Neurovirology, Temple University School of Medicine, Phildelphia, PA 19122, USA
    Biochem J 417:95-101. 2009
    ..In addition, the replacements L38V and P40Q may account for a further 25-fold increase in alpha(1)beta(1) inhibitory potency of viperistatin over KTSR-obtustatin...
  51. ncbi An open, randomized comparative trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelii russelii)
    C A Ariaratnam
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Trans R Soc Trop Med Hyg 95:74-80. 2001
    ..The safety of this larger dose is the subject of further studies...
  52. ncbi A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:542-9. 2006
    ..CLEC-2 is the first C-type lectin receptor to be found on platelets which signals through this novel pathway...
  53. ncbi Structural determinants of the selectivity of KTS-disintegrins for the alpha1beta1 integrin
    Dariusz G Kisiel
    Center for Neurovirology and Cancer Biology, Temple University, College of Science and Technology, 1900 N, 12th Street, Philadelphia, PA 19122, USA
    FEBS Lett 577:478-82. 2004
    ....
  54. ncbi Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 45:997-1011. 2005
    ..In addition, endothelial cells become more susceptible to blood flow-dependent shear stress, which further contributes to capillary wall disruption...
  55. ncbi Protein and cDNA structures of an acidic phospholipase A2, the enzymatic part of an unusual, two-component toxin from Vipera palaestinae
    I Krizaj
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova, Ljubljana, Slovenia
    Biochem Biophys Res Commun 227:374-9. 1996
    ..The substitution of His20 for a hydrophobic residue (Leu) in VpaPLA2 might be one of the reasons that its complex with the basic protein could not be observed...
  56. ncbi Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2)
    Yasuo Yamazaki
    Department of Biochemistry, Meiji Pharmaceutical University, 2 522 1, Noshio, Kiyose, Tokyo 204 8588, Japan
    J Biol Chem 278:51985-8. 2003
    ..Here we show the isolation of two VEGFs from viper venoms and the characterization of their unique biological properties...
  57. doi Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity
    Jay W Fox
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
    FEBS J 275:3016-30. 2008
    ....
  58. ncbi Disintegrins: a family of integrin inhibitory proteins from viper venoms
    R J Gould
    Department of Biological Chemistry, Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    Proc Soc Exp Biol Med 195:168-71. 1990
    ..However, certain nonconserved amino acids appear to modify the activity of disintegrins, their specificity for various receptors, and their ability to compete specifically with various ligands...
  59. pmc Bioinformatics and multiepitope DNA immunization to design rational snake antivenom
    Simon C Wagstaff
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom
    PLoS Med 3:e184. 2006
    ..Here we exploit recent molecular sequence analysis and DNA immunization tools to design more rational toxin-targeted antivenom...
  60. ncbi Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species
    R A Harrison
    Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Gene 315:95-102. 2003
    ....
  61. ncbi Snakebite in northern Cameroon: 134 victims of bites by the saw-scaled or carpet viper, Echis ocellatus
    Ellen M Einterz
    Hôpital de District de Kolofata, B P 111, Mora, Extrême Nord, Cameroon
    Trans R Soc Trop Med Hyg 97:693-6. 2003
    ....
  62. doi Failure of a new antivenom to treat Echis ocellatus snake bite in rural Ghana: the importance of quality surveillance
    L E Visser
    Mathias Hospital, P O Box 43, Yeji B A, Ghana
    Trans R Soc Trop Med Hyg 102:445-50. 2008
    ..ocellatus snake venom. This illustrates the absolute need for regional pilot tests to assess the effectiveness of a new antivenom against local snake venoms before its sole and general distribution in a region is initiated...
  63. ncbi Cloning of a prothrombin activator-like metalloproteinase from the West African saw-scaled viper, Echis ocellatus
    S S Hasson
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Toxicon 42:629-34. 2003
    ..ocellatus metalloproteinase domains may have potential for cross-specific and cross-generic neutralisation of analogous venom toxins...
  64. ncbi Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs--result of alternative-splicing or genome alteration
    E Siigur
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Gene 263:199-203. 2001
    ..The possibilities of generation of such clones via trans-splicing of the primary gene transcript, by exon shuffling or by unequal crossing-over on the genome level are discussed...
  65. ncbi Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa
    J M Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Trans R Soc Trop Med Hyg 99:468-75. 2005
    ..It constitutes a potentially valuable technology for the alleviation of the critical shortage of antivenom in Africa...
  66. ncbi Snake venomics of Bitis species reveals large intragenus venom toxin composition variation: application to taxonomy of congeneric taxa
    Juan J Calvete
    Instituto de Biomedicina de Valencia, C S I C, Jaume Roig 11, 46010 Valencia, Spain
    J Proteome Res 6:2732-45. 2007
    ..g. rhinoceros as a separate species, Bitis rhinoceros. Moreover, our proteomic data fit better to a weighted phylogram based on overall genetic distances than to an unweighted maximum-parsimony tree...
  67. ncbi Hemoperitoneum complicating snake bite: rare CT features
    K Rathod
    Department of Radiology, King Edward VII Memorial Hospital, Parel, Mumbai 400 012, India
    Abdom Imaging 28:820-1. 2003
    ..We report the computed tomographic findings in a case of snake bite resulting in hemoperitoneum, which, to the best of our knowledge, has not been reported in the literature...
  68. ncbi Development of venom toxin-specific antibodies by DNA immunisation: rationale and strategies to improve therapy of viper envenoming
    R A Harrison
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Vaccine 22:1648-55. 2004
    ....
  69. ncbi A nationwide study of Vipera berus bites during one year-epidemiology and morbidity of 231 cases
    Christine Karlson-Stiber
    Swedish Poisons Information Centre, Karolinska Hospital, Stockholm, Sweden
    Clin Toxicol (Phila) 44:25-30. 2006
    ..Design. Retrospective case review study...
  70. ncbi Venom gland EST analysis of the saw-scaled viper, Echis ocellatus, reveals novel alpha9beta1 integrin-binding motifs in venom metalloproteinases and a new group of putative toxins, renin-like aspartic proteases
    Simon C Wagstaff
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, UK
    Gene 377:21-32. 2006
    ..Most significantly, we identified for the first time a conserved alpha(9)beta(1) integrin-binding motif in several SVMPs, and a new group of putative venom toxins, renin-like aspartic proteases...
  71. ncbi Vipera palaestinae envenomation in 327 dogs: a retrospective cohort study and analysis of risk factors for mortality
    G Segev
    School of Veterinary Medicine, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Toxicon 43:691-9. 2004
    ..Specific antivenom therapy (10 ml/dog) was not associated with a higher survival rate, thus its use, dose and timing of administration should be further investigated...
  72. ncbi Analysis of Bothrops jararacussu venomous gland transcriptome focusing on structural and functional aspects: I--gene expression profile of highly expressed phospholipases A2
    Simone Kashima
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, UNAERP, 14096 380 Ribeirão Preto, SP, Brazil
    Biochimie 86:211-9. 2004
    ..Expression of complete cDNAs or their modified derivatives will be useful for elucidation of the structure-function relationships of these toxins and peptides of biotechnological interest...
  73. ncbi Molecular cloning of Echis ocellatus disintegrins reveals non-venom-secreted proteins and a pathway for the evolution of ocellatusin
    Paula Juárez
    Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010, Valencia, Spain
    J Mol Evol 63:183-93. 2006
    ....
  74. ncbi Snake bite in Nigeria
    A G Habib
    Department of Medicine(Immunology, Ahmadu Bello University Teaching Hospital, P.M.B 1026, Zaria, Nigeria
    Afr J Med Med Sci 30:171-8. 2001
    ..A new Fab fragment antivenom specific to Nigerian Echis ocellatus was investigated clinically, just as the local herbs-Aristolochia spp, Guiera spp and Schummaniophyton spp are investigated experimentally...
  75. ncbi Comparative characterisation of Russell's viper (Daboia/Vipera russelli) venoms from different regions of the Indian peninsula
    N B Prasad
    Department of Studies in Biochemistry, University of Mysore, Mysore 570006, India
    Biochim Biophys Acta 1428:121-36. 1999
    ..However, the polyclonal antibodies prepared against southern regional venom showed no protection against lethal toxicity of other regional venoms...
  76. ncbi Toxicity evolution of Vipera aspis aspis venom: identification and molecular modeling of a novel phospholipase A(2) heterodimer neurotoxin
    Virginie Jan
    Unite des Venins, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    FEBS Lett 527:263-8. 2002
    ..It may result from expression of preexisting genes, the acidic subunit evolving from an ancestor common to ammodytin I2 from V. ammodytes ammodytes, which we also found in V. aspis aspis...
  77. ncbi Structure of the neurotoxic complex vipoxin at 1.4 A resolution
    S Banumathi
    Institute of Medical Biochemistry and Molecular Biology, c/o DESY, Building 22a, Notkestrasse 85, 22603 Hamburg, Germany
    Acta Crystallogr D Biol Crystallogr 57:1552-9. 2001
    ..Attempts have been made to identify the toxicity region and to explain the reduced catalytic activity and toxicity of the phospholipase A(2) subunit...
  78. doi Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa
    Alvaro Segura
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 55:369-74. 2010
    ..It therefore constitutes a promising therapeutic option for the treatment of snakebite envenoming in this region...
  79. doi Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria
    S B Abubakar
    General Hospital Kaltungo, Gombe State, Nigeria
    Toxicon 55:719-23. 2010
    ..EgyVac antivenom did not fulfil efficacy or safety criteria in 12 patients. On the basis of these results, ET-G and ET-Plus were selected for comparison in a RCT...
  80. ncbi Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough
    Sandriyana Soelaiman
    Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:25990-7. 2003
    ..It may serve as a lead to design antitoxins to address the role of adenylyl cyclase toxins in bacterial pathogenesis and to fight against anthrax and whooping cough...
  81. ncbi Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus
    J Bryan Smith
    Department of Pharmacology, Sol Sherry Thrombosis Research Center, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    FEBS Lett 512:111-5. 2002
    ..These mutations may modulate the conformation and/or recognition properties of the integrin-binding loop of ocellatusin...
  82. doi Unscrupulous marketing of snake bite antivenoms in Africa and Papua New Guinea: choosing the right product--'what's in a name?'
    David A Warrell
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Trans R Soc Trop Med Hyg 102:397-9. 2008
    ..A major source of confusion is labelling antivenom with ambiguous snake names that fail to distinguish the Asian species whose venoms are used in their production from the local snakes whose venoms are antigenically dissimilar...
  83. ncbi mRNA secondary structure can greatly affect production of recombinant phospholipase A(2) toxins in bacteria
    G Ivanovski
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia
    Toxicon 40:543-9. 2002
    ..Such an approach could be important in solving similar problems in bacterial production of other toxic proteins...
  84. ncbi Molecular characterisation of endogenous snake venom metalloproteinase inhibitors
    Simon C Wagstaff
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Biochem Biophys Res Commun 365:650-6. 2008
    b>Viper venoms contain one of the most potent mixtures of proteases in natural existence and yet the venom gland and proteins in this mixture are refractory to degradation...
  85. ncbi Phospholipase A2 diversity and polymorphism in European viper venoms: paradoxical molecular evolution in Viperinae
    Virginie M Jan
    Unite des Venins, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    Toxicon 50:1140-61. 2007
    ..Most of the European viper venoms studied contained either a myotoxin or a neurotoxin, and all contained ammodytin I1 and ammodytin I2...
  86. ncbi Sequences and structural organization of phospholipase A2 genes from Vipera aspis aspis, V. aspis zinnikeri and Vipera berus berus venom. Identification of the origin of a new viper population based on ammodytin I1 heterogeneity
    Isabelle Guillemin
    Unite des Venins, Institut Pasteur, Paris, France
    Eur J Biochem 270:2697-706. 2003
    ..a. aspis. These results suggest that the population of neurotoxic V. a. aspis snakes from south-east France may have resulted from interbreeding between V. a. aspis and V. am. ammodytes...
  87. ncbi Identification of cDNAs encoding viper venom hyaluronidases: cross-generic sequence conservation of full-length and unusually short variant transcripts
    Robert A Harrison
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Gene 392:22-33. 2007
    ....
  88. doi The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure
    Elizabeth Hooley
    Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, UK
    Biochemistry 47:7831-7. 2008
    ....
  89. ncbi Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity
    E Siigur
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Biochim Biophys Acta 1568:90-8. 2001
    ..VLFXA could not activate prothrombin nor had any effect on fibrinogen, and it had no arginine esterase activity toward benzoylarginine ethyl ester...
  90. ncbi Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom
    J M Howes
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Toxicon 45:677-80. 2005
    ..This could indicate that antivenoms may lack antibodies to potentially important venom components...
  91. ncbi The crystal structure of human endothelin
    R W Janes
    Department of Crystallography, Birkbeck College, University of London, UK
    Nat Struct Biol 1:311-9. 1994
    ..This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity...
  92. ncbi Structural and functional characterization of a mutant of Pseudocerastes persicus natriuretic peptide
    Maryam M Elmi
    Institute of Biochemistry and Biophysics, Tehran University, P O Box 13145 1384, Tehran, Iran
    Protein Pept Lett 13:295-300. 2006
    ..The loss of physiological activity is explained in terms of the modeled bound conformation and the ensemble of solution conformations obtained using the NMR constraints...
  93. ncbi Snakebite during pregnancy
    A Sebe
    Department of Emergency Medicine, School of Medicine, Cukurova University, Balcali Adana, Turkey
    Hum Exp Toxicol 24:341-5. 2005
    ..In this paper, we report on the successful treatment of three cases of snakebite in pregnancy...
  94. pmc Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system
    Libia Sanz
    Instituto de Biomedicina de Valencia, C S I C, Jaume Roig 11, 46010 Valencia, Spain
    Biochem J 395:385-92. 2006
    ....
  95. ncbi Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis
    Kallech Ziri Olfa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis Belvedere, Tunisie
    Lab Invest 85:1507-16. 2005
    ..This disintegrin also affected adhesion and migration of endothelial cells and exhibited an anti-angiogenic effect in vivo when using the 8-day-old embryo chick chorioallantoic membrane model...
  96. ncbi Characterization and molecular cloning of dabocetin, a potent antiplatelet C-type lectin-like protein from Daboia russellii siamensis venom
    Shu Rong Zhong
    Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Toxicon 47:104-12. 2006
    ....
  97. ncbi Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera
    R A Harrison
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Toxicon 47:364-8. 2006
    ..Unexpectedly, we report for the first time that camelid serum contains a non-IgG, highly potent inhibitor of venom-induced haemorrhage...
  98. ncbi Structural and pharmacological comparison of daboiatoxin from Daboia russelli siamensis with viperotoxin F and vipoxin from other vipers
    Gayathri Gopalan
    Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
    Acta Crystallogr D Biol Crystallogr 63:722-9. 2007
    ..Furthermore, an attempt is made to correlate the sequence and structural determinants of these toxins with their enzymatic activities and their pharmacological effects...
  99. ncbi Low incidence of early reactions to horse-derived F(ab')(2) antivenom for snakebites in Thailand
    Aegachai Thiansookon
    Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Acta Trop 105:203-5. 2008
    ..Antivenom can be given in all 10 without reactions. In conclusion, the incidence of early reactions to antivenoms was low in Thailand and skin test is not helpful at all in predicting this adverse reaction...
  100. ncbi Rediscovery of severe saw-scaled viper (Echis sochureki) envenoming in the Thar desert region of Rajasthan, India
    D K Kochar
    S P Medical College Bikaner, Rajasthan, India
    Wilderness Environ Med 18:75-85. 2007
    ..Clinical information is reported on 12 victims bitten by definitively identified E sochureki, and 2 clinical cases are described in greater detail to illustrate the severity of envenoming by this snake...
  101. ncbi Snakes of medical importance in India: is the concept of the "Big 4" still relevant and useful?
    Ian D Simpson
    WHO Snakebite Treatment Group
    Wilderness Environ Med 18:2-9. 2007
    ..It should be replaced by the model introduced in the 1980s by the World Health Organization, which has not received adequate circulation and implementation...

Research Grants71

  1. Melanoma Metastasis Inhibition by Eristostatin
    Mary Ann McLane; Fiscal Year: 2005
    ..This information will, in turn, lead to a rational design of therapeutic agents which would target these cells. ..
  2. Immune Thrombocytopenia and Low-Level Mercury Exposure
    Jodi Segal; Fiscal Year: 2006
    ..Segal with the necessary support for successful completion ..
  3. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    TRAVIS HEIN; Fiscal Year: 2009
    ..Project Description Page 6 ..
  4. Mechanisms of altered venous tone in hypertension
    ALEX PEREZ RIVERA; Fiscal Year: 2005
    ..Answers to these questions will provide a basic understanding of venous function that could lead to better pharmacological approaches not only for hypertension treatment but also for any disease in which there is a vein dysfunction. ..
  5. Patient & Provider Perspectives on Homeopathic Treatment
    Iris Bell; Fiscal Year: 2004
    ..Findings from this proposed study should help clarify the proper premises and parameters on which to base future prospective qualitative and quantitative research in homeopathy. ..
  6. PURINERGIC REGULATION OF THE RENAL MICROVASCULATURE
    EDWARD INSCHO; Fiscal Year: 2007
    ..abstract_text> ..
  7. Polysomnography in Homeopathic Remedy Effects
    Iris Bell; Fiscal Year: 2007
    ..This study will contribute to our long-range goal of understanding the neurophysiological and biopsychosocial mechanisms of classical homeopathic remedy treatment in patients with specific clinical conditions. ..
  8. GPCR Kinase-2 in TNFalpha Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2010
    ..Therefore, understanding the various mechanisms by which TNF-alpha signaling is regulated will help us identify new and novel therapeutic targets to treat atherosclerosis. ..
  9. The Inflammatory Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory Impa
    Edward W Inscho; Fiscal Year: 2010
    ..Understanding the impact of hypertension and inflammation on renal vascular function will provide unique insights capable of reducing hypertensive kidney injury. ..
  10. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2010
    ....
  11. Dilution and Succussion in Homepathic Remedy Dose-Response Patterns
    Iris Bell; Fiscal Year: 2007
    ....
  12. Individual Differences in CAM Patient-Centered Outcomes: Research & Mentorship
    Iris Bell; Fiscal Year: 2007
    ..abstract_text> ..
  13. Arizona Complementary and Alternative Medicine Research Training Program
    Iris Bell; Fiscal Year: 2007
    ..The current proposal reflects several enhancements from an administrative, academic, and curricular perspective that emerged from experience in the first five years of implementing this T32 program. ..
  14. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2007
    ..We have established a system to study phospholipids-driven macromolecular complex formation, which may be a model for the generation of complexes that form extra-and intra-cellularly. ..
  15. PURINERGIC REGULATION OF THE RENAL MICROVASCULATURE
    EDWARD INSCHO; Fiscal Year: 2003
    ..abstract_text> ..
  16. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 1980
    ..This project may reveal an important interaction between neural regulation of body fluid homeostasis and neural regulation of the cardiovascular system in hypertension. ..
  17. NEURAL CONTROL OF FLUID HOMEOSTATIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 1993
    ....
  18. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 1991
    ..The ultimate goal of this work is to define the functional relationships between cardiovascular and body fluid regulatory mechanisms in the central nervous system...
  19. ENDOTHELIN AND NEURAL CONTROL OF VEINS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2002
    ..abstract_text> ..
  20. Integrins and Orthodontic Tooth Movement
    Calogero Dolce; Fiscal Year: 2002
    ..Aim 2 experiments will assess the rate and extent of alveolar bone turnover using histomorphometric means. These data may demonstrate the usefulness of the RGD peptide in modulating both bone formation and resorption during OTM. ..
  21. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2001
    ..These investigations should provide new insights into the link between abnormalities in renal function and/or body fluid regulation and the pathogenesis of hypertension. ..
  22. INSTRUMENTATION FOR PROTEOMICS
    Jay Fox; Fiscal Year: 2001
    ..abstract_text> ..
  23. Quantative and Phospho Proteomics Instrumentation
    Jay Fox; Fiscal Year: 2006
    ....
  24. Purinergic Regulation of the Renal Microcirculation
    Edward W Inscho; Fiscal Year: 2010
    ..This application will address the mechanisms responsible for hypertension-induced impairment of renal vascular function and its relationship to hypertensive kidney damage. ..