rabies vaccines

Summary

Summary: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.

Top Publications

  1. doi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
  2. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
  3. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
  4. ncbi Current status of human rabies transmitted by dogs in Latin America
    Maria Cristina Schneider
    Veterinary Public Health Unit, Pan American Health Organization, Washington, DC 20037 2895, USA
    Cad Saude Publica 23:2049-63. 2007
  5. pmc The feasibility of canine rabies elimination in Africa: dispelling doubts with data
    Tiziana Lembo
    Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 4:e626. 2010
  6. doi Stray dog population demographics in Jodhpur, India following a population control/rabies vaccination program
    Sarah C Totton
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Prev Vet Med 97:51-7. 2010
  7. ncbi Rabies in Estonia: situation before and after the first campaigns of oral vaccination of wildlife with SAG2 vaccine bait
    Enel Niin
    Veterinary and Food Board of Estonia VFB, Väike Paala Street 3, 11415 Tallinn, Estonia, France
    Vaccine 26:3556-65. 2008
  8. pmc Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
  9. pmc Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses
    Joseph E Blaney
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:10605-16. 2011
  10. pmc Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis
    Zélie Lardon
    INSERM, U657 and Institut Pasteur, PhEMI, Paris, France
    PLoS Negl Trop Dis 4:e723. 2010

Research Grants

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
  2. Formulation of Ambient Temperature and Humidity Stable Rabies Vaccines for Oral D
    VICTOR BRONSHTEIN; Fiscal Year: 2010
  3. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2006
  4. STUDIES OF RABIES AND RABIES VIRUS ANTIGENS
    Hilary Koprowski; Fiscal Year: 1991
  5. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
  6. Human Rabies Virus Vaccine Development
    James McGettigan; Fiscal Year: 2009
  7. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2005
  8. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2004
  9. Reservoir Vaccines
    Alan Barbour; Fiscal Year: 2009
  10. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2003

Detail Information

Publications332 found, 100 shown here

  1. doi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
    ..Little data exist about the spatial distribution of the risk for travelers of being injured by a potentially rabid animal...
  2. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
    ..Prompt rabies PEP combining wound care, infiltration of RIG into and around the wound, and multiple doses of rabies cell-culture vaccine continue to be highly effective in preventing human rabies...
  3. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
    ..To quantify the public health and economic burden of endemic canine rabies in Africa and Asia...
  4. ncbi Current status of human rabies transmitted by dogs in Latin America
    Maria Cristina Schneider
    Veterinary Public Health Unit, Pan American Health Organization, Washington, DC 20037 2895, USA
    Cad Saude Publica 23:2049-63. 2007
    ..Samples sent for rabies testing represent 0.05% of the estimated canine population (range: 0.001 to 0.2%). The countries are quite close to achieving the goal...
  5. pmc The feasibility of canine rabies elimination in Africa: dispelling doubts with data
    Tiziana Lembo
    Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 4:e626. 2010
    ..Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent...
  6. doi Stray dog population demographics in Jodhpur, India following a population control/rabies vaccination program
    Sarah C Totton
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Prev Vet Med 97:51-7. 2010
    ..A surgical sterilization coverage under 40% would maintain the dog population at current levels...
  7. ncbi Rabies in Estonia: situation before and after the first campaigns of oral vaccination of wildlife with SAG2 vaccine bait
    Enel Niin
    Veterinary and Food Board of Estonia VFB, Väike Paala Street 3, 11415 Tallinn, Estonia, France
    Vaccine 26:3556-65. 2008
    ..5%) occurred within the vaccinated area. Only 17 cases were diagnosed between 1 June and 31 December 2006. In 2007, by the end of May, only two rabies cases have been registered...
  8. pmc Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
    ..This robust microassay will improve our understanding of the protective humoral immunity that current rabies vaccines confer against emerging lyssaviruses, and will be applicable to surveillance studies, thus helping to control ..
  9. pmc Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses
    Joseph E Blaney
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:10605-16. 2011
    ....
  10. pmc Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis
    Zélie Lardon
    INSERM, U657 and Institut Pasteur, PhEMI, Paris, France
    PLoS Negl Trop Dis 4:e723. 2010
    ....
  11. ncbi Control of rabies in Jaipur, India, by the sterilisation and vaccination of neighbourhood dogs
    J F Reece
    Help in Suffering, Maharani Farm, Durgapura, Jaipur 302018, Rajasthan, India
    Vet Rec 159:379-83. 2006
    ..The records of human cases of rabies seen in the main government hospital of the city between January 1992 and December 2002 showed that the number of cases had declined to zero in the programme area but increased in other areas...
  12. pmc Transmission dynamics and prospects for the elimination of canine rabies
    Katie Hampson
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
    PLoS Biol 7:e53. 2009
    ..Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal...
  13. pmc Rabies trend in China (1990-2007) and post-exposure prophylaxis in the Guangdong province
    Han Si
    1Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, PR China
    BMC Infect Dis 8:113. 2008
    ....
  14. doi Evidence for a 4-dose vaccine schedule for human rabies post-exposure prophylaxis in previously non-vaccinated individuals
    Charles E Rupprecht
    National Center for Zoonotic, Vector Borne and Enteric Diseases, 1600 Clifton Road N E, Atlanta, GA 30333, USA
    Vaccine 27:7141-8. 2009
    ....
  15. pmc Characterization of a single-cycle rabies virus-based vaccine vector
    Emily A Gomme
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Virol 84:2820-31. 2010
    ..These findings demonstrate that single-cycle RV is an effective alternative to replication-competent RV vectors for future development of vaccines for HIV-1 and other infectious diseases...
  16. ncbi Rabies surveillance in the United States during 2011
    Jesse D Blanton
    Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Disease, CDC, Atlanta, GA 30333, USA
    J Am Vet Med Assoc 241:712-22. 2012
    ..Three cases reported from Massachusetts, New Jersey, and New York were determined to be a result of canine rabies virus variants acquired outside the United States...
  17. pmc Rabies virus glycoprotein as a carrier for anthrax protective antigen
    Mary Ellen Smith
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 353:344-56. 2006
    ..These data demonstrate that a viral envelope protein can carry a bacterial protein and that a viral carrier can display whole polypeptides compared to the limited epitope presentation of previous viral systems...
  18. ncbi Failure of pre- and postexposure rabies vaccinations in a child infected with HIV
    C Pancharoen
    Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Scand J Infect Dis 33:390-1. 2001
    ..Sequentially monitored rabies neutralizing antibody titers were below the WHO minimum acceptable level (> 0.15 IU/ml) in all specimens. Rabies prevention in HIV-infected persons with severe immune suppression requires further study...
  19. doi Failure of rabies postexposure prophylaxis in patients presenting with unusual manifestations
    Prapimporn Shantavasinkul
    Queen Saovabha Memorial Institute, The Thai Red Cross Society World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention, Bangkok, Thailand
    Clin Infect Dis 50:77-9. 2010
    ..Atypical presentations and history of rabies postexposure prophylaxis led to delayed diagnosis. Nucleocapsid and glycoprotein genes of rabies viruses from the patient's and biting dog's brains were of identical sequences...
  20. doi Overview, prevention, and treatment of rabies
    Andrea Julia Nigg
    Department of Pharmacy Services, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    Pharmacotherapy 29:1182-95. 2009
    ..The recently developed Milwaukee Protocol added induction of therapeutic coma to supportive care measures and antivirals; however, its use has shown inconsistent outcomes...
  21. ncbi Epidemiology of animal bites and rabies cases in India. A multicentric study
    R L Ichhpujani
    WHO Collaborating Centre for Rabies Epidemiology, National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi
    J Commun Dis 40:27-36. 2008
    ..There is a need to create awareness regarding epidemiology and at-home and hospital management of animal bites among the service providers and general community...
  22. ncbi The immune response to rabies virus infection and vaccination
    Nicholas Johnson
    Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
    Vaccine 28:3896-901. 2010
    ..This could help identify ways in which the response to prophylactic vaccination can be enhanced and how the natural immune response to infection can be boosted to combat neuroinvasion...
  23. pmc Experimental rabies vaccines for humans
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Vaccine Center, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, JAH 466, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 9:1177-86. 2010
    ..The usefulness of human rabies vaccines is hampered by high cost, complicated vaccination regimens and lack of compliance, especially in areas of ..
  24. ncbi Efficacy of an oral vaccinia-rabies glycoprotein recombinant vaccine in controlling epidemic raccoon rabies in New Jersey
    D E Roscoe
    New Jersey Division of Fish, Game and Wildlife, Trenton 08625 0400, USA
    J Wildl Dis 34:752-63. 1998
    ....
  25. doi Immune response after rabies vaccine in a kidney transplant recipient
    R Rodríguez-Romo
    Transplantation Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Transpl Infect Dis 13:492-5. 2011
    ..Nevertheless, such an outcome would have been possible only with the combined management strategy implemented...
  26. pmc Reemergence of rabies in Chhukha district, Bhutan, 2008
    - Tenzin
    The University of Sydney, Camden, New South Wales, Australia
    Emerg Infect Dis 16:1925-30. 2010
    ..The outbreak was controlled by culling free-roaming dogs. To prevent spread into the interior of Bhutan, a well-coordinated national rabies control program should be implemented in disease-endemic areas...
  27. pmc Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Vaccine 26:6405-14. 2008
    ....
  28. doi Knowledge, attitudes, and practices of French travelers from Marseille regarding rabies risk and prevention
    Matthias Altmann
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, Marseille, France
    J Travel Med 16:107-11. 2009
    ..To assess the awareness of the mode of rabies transmission, travel-associated rabies risk, and adequate preventive measures among French travelers...
  29. ncbi Safety and efficacy of the oral rabies vaccine SAG2 in raccoon dogs
    F Cliquet
    AFSSA Nancy, WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Community Reference Laboratory for Rabies Serology, Domaine de Pixerecourt, Malzeville, France
    Vaccine 24:4386-92. 2006
    ..All 28 vaccinated animals developed high rabies neutralizing antibody titres. After virulent challenge, all 11 controls succumbed to rabies, whereas all 28 vaccinates survived...
  30. ncbi Human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, between 2002 and 2006
    Filipe Dantas-Torres
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Soc Bras Med Trop 40:617-21. 2007
    ....
  31. ncbi Rabies update for travel medicine advisors
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Clin Infect Dis 37:96-100. 2003
    ..Safe and effective tissue-culture rabies vaccines and human and equine rabies immunoglobulins (HRIG and ERIG) are not readily available in many regions where ..
  32. ncbi Cryptogenic rabies, bats, and the question of aerosol transmission
    Robert V Gibbons
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Ann Emerg Med 39:528-36. 2002
    ..The known pathogenesis of rabies and available data suggest that all or nearly all cases of human rabies attributable to bats were transmitted by bat bites that were minimized or unrecognized by the patients...
  33. pmc Epidemiological investigations of human rabies in China
    Miao Song
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, PR China
    BMC Infect Dis 9:210. 2009
    ..Moreover, the status of rabies infection and vaccination in dogs, and prophylaxis of humans after rabies exposure were analyzed...
  34. ncbi Clinical practice. Prophylaxis against rabies
    Charles E Rupprecht
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 351:2626-35. 2004
  35. ncbi Elimination of rabies from red foxes in eastern Ontario
    C D MacInnes
    Rabies Unit, Ontario Ministry of Natural Resources, Peterborough, Canada
    J Wildl Dis 37:119-32. 2001
    ..Persistence of terrestrial rabies, and ease of elimination, appeared to vary geographically, and probably over time. Ecological factors which enhance or reduce the long term survival of rabies in wild foxes are poorly understood...
  36. pmc Oral vaccination of mice with adenoviral vectors is not impaired by preexisting immunity to the vaccine carrier
    Z Q Xiang
    The Wistar Institute Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:10780-9. 2003
    ..Oral priming-boosting regimens with either heterologous or homologous adenoviral vectors used sequentially increased both mucosal and systemic antibody titers to rabies virus [corrected]..
  37. ncbi Genetic characterisation of attenuated SAD rabies virus strains used for oral vaccination of wildlife
    Lutz Geue
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
    Vaccine 26:3227-35. 2008
    ..Our data also supports the idea of a possible recombination that had occurred during the derivation of the European branch of SAD viruses. If confirmed, this recombination event would be the first one reported among RABV vaccine strains...
  38. pmc Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
    Kalifa Bojang
    Medical Research Council Laboratories, Banjul, The Gambia
    Hum Vaccin 5:242-7. 2009
    ..This study provides the first indication of the long-term safety and persistence of anti-CS and anti-HBs antibodies of the RTS,S vaccine candidate in combination with the novel AS02 Adjuvant System...
  39. ncbi A quantitative indirect ELISA to monitor the effectiveness of rabies vaccination in domestic and wild carnivores
    A Servat
    AFSSA Nancy, Laboratoire d Etudes et de Recherches sur la Rage et la Pathologie des Animaux Sauvages, Domaine de Pixerecourt, B P 9 54220 Malzéville, France
    J Immunol Methods 318:1-10. 2007
    ....
  40. doi Characterization of Russian rabies virus vaccine strain RV-97
    A Metlin
    Department of Animal Diseases and Food Safety Research, Virology, Mustialankatu 3, FI 00790 Helsinki, Finland
    Virus Res 132:242-7. 2008
    ..It also contains several unique amino acid changes in known immunodominant sites of G and P proteins...
  41. pmc Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus
    Milosz Faber
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 106:11300-5. 2009
    ....
  42. pmc Oral rabies vaccination in north america: opportunities, complexities, and challenges
    Dennis Slate
    USDA APHIS Wildlife Services, National Rabies Management Program, Concord, New Hampshire, USA
    PLoS Negl Trop Dis 3:e549. 2009
    ..Progress continues toward the development and testing of new bait-vaccine combinations that increase the chance for improved delivery and performance in the diverse meso-carnivore rabies reservoir complex in the US...
  43. pmc Protective vaccine-induced CD4(+) T cell-independent B cell responses against rabies infection
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Virol 86:11533-40. 2012
    ..We show that vaccines that can exploit early pathways of B cell activation and development may hold the key for the development of a single-dose RV vaccine wherein the rapid induction of VNA is critical...
  44. ncbi Identification of a conserved linear epitope at the N terminus of the rabies virus glycoprotein
    K L Mansfield
    Rabies Research and Diagnostic Group WHO Collaborating Centre, Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Surrey, KT15 3NB, UK
    J Gen Virol 85:3279-83. 2004
    ..In a multimeric form, the peptide could induce an epitope-specific response following immunization in rabbits and mice...
  45. ncbi The control of raccoon rabies in Ontario Canada: proactive and reactive tactics, 1994-2007
    R C Rosatte
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, Peterborough, Ontario, Canada
    J Wildl Dis 45:772-84. 2009
    ..The last case occurred on 23 September 2005 with Ontario being free of reported raccoon rabies to 10 November 2008, proving that TVR and PIC are effective tactics for the control of this disease...
  46. doi Fatal rabies despite post-exposure prophylaxis
    D G Deshmukh
    Department of Microbiology, Government Medical College, Panchakki Road, Aurangabad 431 001, Maharashtra, India
    Indian J Med Microbiol 29:178-80. 2011
    ....
  47. ncbi Animal bites and rabies exposure in Australian travellers
    Deborah J Mills
    Dr Deb The Travel Doctor, Brisbane, QLD
    Med J Aust 195:673-5. 2011
    ..To examine the circumstances of animal exposure in a case series of Australian travellers who required rabies postexposure prophylaxis, and to assess the appropriateness of current guidelines for rabies pre-exposure vaccination...
  48. ncbi Effect of maternal immunity on the immune response to oral vaccination against rabies in young foxes
    T F Müller
    Institute for Epidemiological Diagnostics, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
    Am J Vet Res 62:1154-8. 2001
    ..To determine effect of maternal antibodies on immune response to oral vaccination against rabies in young foxes...
  49. ncbi Immunogenicity and efficacy of two rabies vaccines in wild-caught, captive raccoons
    L J Brown
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, 2140 East Bank Drive, Peterborough, Ontario K9J 7B8, Canada
    J Wildl Dis 47:182-94. 2011
    The immunogenicity and efficacy of two rabies vaccines in wild-caught, captive raccoons (Procyon lotor) were investigated...
  50. ncbi Low-coverage vaccination strategies for the conservation of endangered species
    D T Haydon
    Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Nature 443:692-5. 2006
    ....
  51. doi Intra-dermal administration of rabies vaccines in developing countries: at an affordable cost
    RAMESH VERMA
    Department of Community Medicine, Pt B D Sharma PGIMS, Rohtak, Haryana, India
    Hum Vaccin 7:792-4. 2011
    ..The ID route is ideal in terms of economic benefits, safety and efficacy. This reduces the cost of vaccination by about 68%, which is clearly an attractive option for resource-starved countries like India...
  52. ncbi Rabies re-examined
    Charles E Rupprecht
    Rabies Section, WHO Collaborating Centre for Reference and Research on Rabies, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 2:327-43. 2002
    ..Nevertheless, despite much technical progress in the past century, rabies is a disease of neglect and presents a modern public-health conundrum...
  53. pmc Risk for rabies importation from North Africa
    Philippe Gautret
    Hopital Nord, Marseille, France
    Emerg Infect Dis 17:2187-93. 2011
    ..Rabies surveillance and control should therefore be reinforced in North Africa, and travelers to North Africa should receive appropriate information about rabies risk and prevention...
  54. ncbi Rabies remains a 'neglected disease'
    A R Fooks
    Euro Surveill 10:1-2. 2005
  55. ncbi Optimal control of vaccine distribution in a rabies metapopulation model
    Erika Asano
    Environmental Science, Policy and Geography Univesity of South Florida, St Petersburg, FL 33701, USA
    Math Biosci Eng 5:219-38. 2008
    ..This strategy is chosen to limit the disease optimally by making the number of infections as small as possible while accounting for the cost of vaccination...
  56. ncbi Characterization of P gene-deficient rabies virus: propagation, pathogenicity and antigenicity
    Kinjiro Morimoto
    Department of Virology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Virus Res 111:61-7. 2005
    ..The def-P virus would be a potential resource of safe live-attenuated rabies vaccine...
  57. pmc Transmission dynamics and economics of rabies control in dogs and humans in an African city
    J Zinsstag
    Swiss Tropical Institute, PO Box, CH 4002 Basle, Switzerland
    Proc Natl Acad Sci U S A 106:14996-5001. 2009
    ..Beyond a time-frame of 7 years, it appears to be more cost-effective to combine parenteral dog-vaccination campaigns with human PEP compared to human PEP alone...
  58. ncbi Nonclinical toxicology study of recombinant-plasmid DNA anti-rabies vaccines
    P Uday Kumar
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, Andhra Pradesh 500007, India
    Vaccine 24:2790-8. 2006
    ..There were no observational adverse effects even at levels of 10x therapeutic dose administration of DRV and CRV. The procedure also emphasizes on the designing of protocols for the products developed by recombinant technique...
  59. ncbi Immunogenicity, safety and lot consistency in adults of a chromatographically purified Vero-cell rabies vaccine: a randomized, double-blind trial with human diploid cell rabies vaccine
    R L Jones
    Department of Microbiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1677, USA
    Vaccine 19:4635-43. 2001
    ..The results of these studies indicate that CPRV administered intramuscularly to healthy adults is immunogenic and is associated with fewer local and systemic reactions than HDCV...
  60. pmc Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 200:1251-60. 2009
    ..The data presented in this article suggest that the M gene-deleted RV vaccine is safe and effective and holds the potential of replacing current pre- and postexposure RV vaccines...
  61. ncbi [Immune response produced by anti-rabies vaccines in marmosets (Callithrix sp)]
    M C Andrade
    Laboratorio de Biologia Animal, Empresa de Pesquisa Agropecuária do Estado do Rio de Janeiro, Niteroi, RJ, Brasil
    Rev Soc Bras Med Trop 32:533-40. 1999
    In order to evaluate the immune response produced by rabies vaccines in new world nonhuman primates, thirty marmosets (Callithrix sp) were divided into five groups of six individuals and submitted to five different antirabies vaccination ..
  62. ncbi Post-exposure therapy in mice against experimental rabies: a single injection of DNA vaccine is as effective as five injections of cell culture-derived vaccine
    Chokri Bahloul
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, 13 Place Pasteur BP 74, 1002, Tunis Belvedere, Tunisia
    Vaccine 22:177-84. 2003
    ..We conclude that rabies post-exposure vaccination in BALB/c mice, based on a single administration of rabies DNA vaccine might be at least as effective as five injections of cell culture-derived vaccine...
  63. ncbi Field evaluation of an inactivated vaccine to control raccoon rabies in Ontario, Canada
    K G Sobey
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, 2140 East Bank Dr, Peterborough, Ontario K9J 7B8, Canada
    J Wildl Dis 46:818-31. 2010
    ..A strong anamnestic response was detected after booster vaccinations. IMRAB3 by IM injection was found to be an efficacious vaccine for rabies control in raccoons...
  64. ncbi Attaining raccoon rabies management goals: history and challenges
    D Slate
    United States Department of Agriculture, Animal and Plant Heath Inspection Service, Wildlife Services, Concord, NH 03301, USA
    Dev Biol (Basel) 131:439-47. 2008
    ..We report on the challenges of achieving enhanced rabies surveillance, containment of raccoon rabies, and local elimination of raccoon rabies, as well as the need for international coordination in meeting these challenges...
  65. doi Rabies post-exposure prophylaxis in travellers returning from Bali, Indonesia, November 2008 to March 2010
    P Gautret
    Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, France
    Clin Microbiol Infect 17:445-7. 2011
    ..The data demonstrate that the majority of animal-related injuries in travellers returning from Bali are associated with exposure to monkeys, and not dog bites/scratches. The clinical implications of this are discussed...
  66. pmc A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence
    Amy B Papaneri
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA
    Virology 434:18-26. 2012
    ..In summary, our findings indicate that RV-GP retains the attenuation phenotype of the live-attenuated RABV vaccine, and RVΔG-GP would appear to be an even safer alternative for use in wildlife or consideration for human use...
  67. ncbi Development of a bait and baiting system for delivery of oral rabies vaccine to free-ranging African wild dogs (Lycaon pictus)
    D L Knobel
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa
    J Wildl Dis 38:352-62. 2002
    ..During 46 hr of diurnal observations of free-ranging wild dogs only two baits were lost to non-target species. A baiting system for the oral vaccination of captive and free-ranging wild dogs is proposed...
  68. ncbi Characterization of recombinant rabies virus carrying double glycoprotein genes
    Junji Hosokawa-Muto
    The United Graduate School of Veterinary Sciences, Faculty of Applied Biological Sciences, Gifu University, Gifu 501 1193, Japan
    Microbiol Immunol 50:187-96. 2006
    ..The results suggest that the R(NPMGGL) strain carrying double G genes might be a useful candidate for development of a new inactivated rabies vaccine...
  69. pmc Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation
    Lihong Tao
    Veterinary Public Health Laboratory of Ministry of Agriculture, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
    J Virol 84:8926-36. 2010
    ..These results indicate that attenuation of the RV Flury strain results from the coevolution of G and L elements and provide important information for the generation of safer and more effective modified live rabies vaccine...
  70. ncbi Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland
    P Bugnon
    Institute of Cell Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Vet Med B Infect Dis Vet Public Health 51:433-7. 2004
    ..The theoretical implication of the successful elimination of fox rabies in Switzerland in spite of a relatively low overall proportion of VNA-positive animals is discussed...
  71. ncbi [Human rabies in France in 2004: update and management]
    H Peigue-Lafeuille
    Service de Virologie, Faculte de Medecine, 28, Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    Med Mal Infect 34:551-60. 2004
    ..People traveling abroad, particularly to Africa, are warned not to approach unknown animals (especially dogs) nor to try to import them, and are advised to comply with vaccinal recommendations for travelers, particularly for toddlers...
  72. ncbi Rabies in wildlife in Latvia
    Sanita Vanaga
    Department of Virology, National Veterinary Laboratory, Latvia
    Vector Borne Zoonotic Dis 3:117-24. 2003
    ..To successfully eradicate the wildlife reservoirs, the national rabies eradication program must be continued, and it may need to be intensified...
  73. ncbi Vaccinating the vampire bat Desmodus rotundus against rabies
    M F Almeida
    School of Medicine, University of São Paulo and LIM01 HCFMUSP, Brazil Laboratory of Rabies, Zoonosis Control Center of São Paulo City, Brazil
    Virus Res 137:275-7. 2008
    ..A dose of 10(5.0) MICLD(50) rabies virus was used by intramuscular route to challenge the bats postvaccination. The survival proportion in the three groups after the challenge was 71.4%, 71.4% and 100%...
  74. ncbi The global fight against rabies
    Talha Burki
    Lancet 372:1135-6. 2008
  75. ncbi Cost-efficient vaccination of foxes (Vulpes vulpes) against rabies and the need for a new baiting strategy
    T Selhorst
    Federal Research Centre for Virus Diseases of Animals, WHO Collaborating Centre for rabies in Central and Eastern Europe, Institute for Epidemiology, Seetr 55, D 16868, Wusterhausen, Germany
    Prev Vet Med 51:95-109. 2001
    ..We concluded that distribution of baits in June was optimal given that the durability of baits is above a threshold of 7 days...
  76. ncbi Acceptance of baits for delivery of oral rabies vaccine to raccoons
    R C Rosatte
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Rabies Research and Development Unit, Trent University, Science Complex, P O Box 4840, Peterborough, Ontario K9J 8N8, Canada
    J Wildl Dis 37:730-9. 2001
    ..Puncture and impact testing of blister packs in baits suggested that they would adequately serve as a vehicle to contain oral rabies vaccine for delivery to raccoons via baits...
  77. doi Evaluation of mass vaccination campaign coverage against rabies in dogs in Tunisia
    L Touihri
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Zoonoses Public Health 58:110-8. 2011
    ..The achieved vaccination coverage should be estimated after random visits in many parts of the country and by checking valid vaccination certificates...
  78. ncbi [The first case of rabies in Sweden in 26 years. Inform travellers abroad about risks and treatment following suspected infection]
    J Hojer
    Infektionskliniken, Södersjukhuset Huddinge Universitetssjukhus
    Lakartidningen 98:1216-20. 2001
    ..Tourists must be informed of the vital importance of post-exposure prophylaxis after suspected infection...
  79. doi Safety and immunogenicity of two freeze-dried Vero cell rabies vaccines for human use in post-exposure prophylaxis
    Ling yun Wang
    Beijing Center for Diseases Prevention and Control, Beijing 100013, China
    Vaccine 29:2679-81. 2011
    ..basis for human rabies vaccination in China, the safety and immunogenicity of two freeze-dried Vero cell rabies vaccines for human use were assessed...
  80. ncbi Comparative immunogenicity and efficacy studies with oral rabies virus vaccine SAD P5/88 in raccoon dogs and red foxes
    P Schuster
    Institute of Epidemiological Diagnostics, Federal Research Centre for Virus Diseases of Animals, Wusterhausen, Germany
    Acta Vet Hung 49:285-90. 2001
    ..Also all control foxes succumbed to rabies. Our findings demonstrate that SAD P5/88 is not only an effective vaccine for oral vaccination of foxes but also for that of raccoon dogs...
  81. ncbi Characterization of human rabies virus vaccine strain in China
    Jialiang Du
    Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control, Xuan Wu District, Beijing, China
    Virus Res 135:260-6. 2008
    ..In addition, some mutations and new functional regions were discovered that are presumed crucial to the function of leader region and L protein. There is an equal role for all five genes in the phylogenetics of rabies virus...
  82. ncbi Inter-laboratory trial to evaluate the reproducibility of a new ELISA to detect rabies antibodies in vaccinated domestic and wild carnivores
    A Servat
    WHO collabarating Centre for Research and Management in Zoonoses Control, Community Reference Institute for Rabies Serology, Technopole Agricole et Vétérinaire, BP 40009, 54220 Malzéville cedex, France
    Biologicals 36:19-26. 2008
    ....
  83. ncbi Efficacy and bait acceptance of vaccinia vectored rabies glycoprotein vaccine in captive foxes (Vulpes vulpes), raccoon dogs (Nyctereutes procyonoides) and dogs (Canis familiaris)
    F Cliquet
    AFSSA NANCY Laboratory of Research on Rabies and Wildlife Diseases, WHO Collaborating Centre for Research and Management in Zoonoses Control, Technopole Agricole et Vétérinaire, B P 40009, 54220 Malzeville, France
    Vaccine 26:4627-38. 2008
    ..The square RABORAL V-RG bait, however, was consumed more effectively than the rectangular RABORAL V-RG bait by the raccoon dog...
  84. doi Landscape genetics of raccoons (Procyon lotor) associated with ridges and valleys of Pennsylvania: implications for oral rabies vaccination programs
    J Jeffrey Root
    United States Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado 80521, USA
    Vector Borne Zoonotic Dis 9:583-8. 2009
    ..These results may be of value for future ORV efforts in Pennsylvania and other eastern states with similar landscapes...
  85. ncbi Comparison of saftey and immunogenicity of purified chick embryo cell rabies vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) using the Thai Red Cross intradermal regimen at a dose of 0.1 ML
    Shampur N Madhusudana
    Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Hum Vaccin 2:200-4. 2006
    Intradermal (ID) vaccination with modern cell culture rabies vaccines is a means to significantly reduce the cost of post-exposure prophylaxis as compared to intramuscular vaccination...
  86. doi Peptide mimotopes of rabies virus glycoprotein with immunogenic activity
    Mehdi Houimel
    Laboratoire d Immunopathologie Vaccinologie et Génétique Moléculaire, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Vaccine 27:4648-55. 2009
    ..The RABVG site III mimotope (C-KRDSTW-C) would provide a new and promising concept for the development of rabies vaccine...
  87. doi Postexposure rabies prophylaxis completed in 1 week: preliminary study
    Prapimporn Shantavasinkul
    Queen Saovabha Memorial Institute, The Thai Red Cross Society World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention, Bangkok, Thailand
    Clin Infect Dis 50:56-60. 2010
    ..Reducing the number of clinic visits would not only reduce costs for the patient but may also help increase compliance to receive complete PEP. We made an effort to develop PEP completed in 1 week...
  88. ncbi Factors affecting the serological response of dogs and cats to rabies vaccination
    K L Mansfield
    Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Surrey KT15 3NB
    Vet Rec 154:423-6. 2004
    ..In dogs, all these factors, except sex, had highly significant (P < 0.001) effects on the test failure rate, and in cats all the factors had a significant effect (P < 0.05)...
  89. ncbi Rapid clearance of SAG-2 rabies virus from dogs after oral vaccination
    L A Orciari
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, Rabies Section, Mailstop G 33, Atlanta, GA 30333, USA
    Vaccine 19:4511-8. 2001
    ..Attenuated rabies viruses, such as SAG-2, replicate in local tissues of the oral cavity and can be cleared relatively quickly, without viral excretion, leading to protective immunity against the disease...
  90. doi Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines
    Richard Franka
    Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Vaccine 27:7149-55. 2009
    ..Reduced vaccine schedules provided efficacious intervention, regardless of the total number of vaccine doses administered...
  91. doi Comparison of antibody responses after vaccination with two inactivated rabies vaccines
    J M Minke
    Merial SAS, 254, rue Marcel Merieux, 69007 Lyon, France
    Vet Microbiol 133:283-6. 2009
    ..and subcutaneously vaccinated with a single dose of one of two commercially available monovalent inactivated rabies vaccines: RABISIN (Merial, France) (group A) and NOBIVAC Rabies (Intervet International) (group B)...
  92. ncbi Factors influencing the antibody response of dogs vaccinated against rabies
    Lorna J Kennedy
    Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Vaccine 25:8500-7. 2007
    ....
  93. pmc Evaluating the cost-effectiveness of rabies post-exposure prophylaxis: a case study in Tanzania
    Eunha Shim
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06510, USA
    Vaccine 27:7167-72. 2009
    ..Moreover, PEP remains "very cost-effective" provided that at least 1% of doses are administered to people who were actually exposed to rabies...
  94. doi Ovine anti-rabies antibody production and evaluation
    el Rashdy M Redwan
    Protein Research Department, Genetic Engineering and Biotechnology Research Institute, Mubarak City for Scientific Research and Technology Applications, Alexandria, Egypt
    Comp Immunol Microbiol Infect Dis 32:9-19. 2009
    ..Sheep's IgG has low immunogenic effect than human and horse antibodies when injected into the mouse. Pure concentrated ovine antibody may serve as a possible alternative to currently available anti-rabies human or equine immunoglobulin...
  95. ncbi Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine
    Thavachai Kamoltham
    Provincial Health Department, Petchabun Province, Queen Saovabha Memorial Institute of the Thai Red Cross Society, Department of Medicine, Chulalongkorn University, Bangkok, Thailand
    Vaccine 20:3272-6. 2002
    ..The modified TRC-ID method induces adequate levels of neutralizing antibodies, protects humans bitten by rabid dogs and results in significant savings in vaccine and travel costs...
  96. pmc Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine
    D J Briggs
    College of Veterinary Medicine, Kansas State University, USA
    Bull World Health Organ 78:693-8. 2000
    ..introduction of tissue culture vaccines for rabies has dramatically improved the immunogenicity and safety of rabies vaccines, they are often prohibitively expensive for developing countries...
  97. pmc Human benefits of animal interventions for zoonosis control
    Jakob Zinsstag
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 13:527-31. 2007
    ....
  98. ncbi Evaluation of state-provided postexposure prophylaxis against rabies in Florida
    Lisa Conti
    Florida Department of Health, Tallahassee, USA
    South Med J 95:225-30. 2002
    ..One key component of human rabies prevention is the use of postexposure prophylaxis (PEP). No information is routinely available to evaluate the appropriateness of this intervention...
  99. pmc Canine rabies ecology in southern Africa
    John Bingham
    Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Emerg Infect Dis 11:1337-42. 2005
    ..The implications for understanding rabies ecology and control are reviewed, as are previous studies on rabies ecology in African canids...
  100. pmc Comparative evaluation of specific ELISA and RFFIT antibody assays in the assessment of dog immunity against rabies
    C Bahloul
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, Tunisia
    Epidemiol Infect 133:749-57. 2005
    ..A seroconversion threshold of 0.5 IU/ml should be cautiously considered and a higher threshold (1 IU/ml) could be more appropriate in the evaluation of rabies immunity in the field in order to marginalize the interfering factors...
  101. pmc Inferior rabies vaccine quality and low immunization coverage in dogs ( Canis familiaris) in China
    R L Hu
    Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, Changchun, China
    Epidemiol Infect 136:1556-63. 2008
    ..Results also indicated that the quality of rabies vaccines for animal use did not satisfy all of the requirements for an efficacious vaccine capable of fully ..

Research Grants88

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  2. Formulation of Ambient Temperature and Humidity Stable Rabies Vaccines for Oral D
    VICTOR BRONSHTEIN; Fiscal Year: 2010
    ..The specific aims of the Phase II project are to: 1) Optimize formulation of dry preserved rabies vaccines encapsulated in alginate gel microspheres...
  3. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2006
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. We hypothesize that replication-deficient RVs will make excellent rabies PEPs...
  4. STUDIES OF RABIES AND RABIES VIRUS ANTIGENS
    Hilary Koprowski; Fiscal Year: 1991
    ..Murine MAbs to natural virus isolates will be produced in order to refine our understanding of rabies epidemiology and diagnose the potential sources of exposure of humans and domestic animals lacking a firm history of animal bite...
  5. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. We hypothesize that replication-deficient RVs will make excellent rabies PEPs...
  6. Human Rabies Virus Vaccine Development
    James McGettigan; Fiscal Year: 2009
    ..of passive immunization [(rabies immune globulin (RIG)] along with five active immunizations with inactivated rabies vaccines. The experiments in this proposal are designed to test the hypothesis that a matrix (M) gene-deleted RV ..
  7. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2005
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  8. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2004
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  9. Reservoir Vaccines
    Alan Barbour; Fiscal Year: 2009
    ..The source of residual blood proteins and/or mitochondria! DNA will be identified by mass spectrometry of peptide digests and/or by PCR. ..
  10. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2003
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  11. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  12. STUDY OF RABIES AND RABIES VIRUS ANTIGENS
    Hilary Koprowski; Fiscal Year: 1980
    ....
  13. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2004
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  14. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2003
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  15. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2005
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  16. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2002
    ..II objectives of this research project are to extend safety and efficacy testing of these newly developed rabies vaccines in laboratory rodents and target animals (raccoon and skunk), and to choose a strain for which a master seed ..
  17. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2003
    ..II objectives of this research project are to extend safety and efficacy testing of these newly developed rabies vaccines in laboratory rodents and target animals (raccoon and skunk), and to choose a strain for which a master seed ..
  18. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2000
    ..Unfortunately, the currently available oral rabies vaccines induce insufficient immunity in dogs or skunks...
  19. NOVEL METHODS FOR TREATMENT AND POSTEXPOSURE PROPHYLAXIS
    Thomas Monath; Fiscal Year: 1993
    ..The toxicology and efficacy studies will provide detailed information on the usefulness of the B9 anti-id for treatment and prophylaxis of human rabies...
  20. NONINVASIVE DELIVERY OF SKIN-TARGETED RABIES VACCINES
    DE CHU TANG; Fiscal Year: 2001
    ..Adapted from Applicant's Abstract) Our aim is to develop a simple and effective method for the delivery of rabies vaccines by topical application of adenovirus-based expression vectors using a skin patch in a noninvasive mode...
  21. Formulation of Ambient Temperature and Humidity Stable Rabies Vaccines for Oral D
    VICTOR BRONSHTEIN; Fiscal Year: 2008
    ..Currently, about 15 states distribute edible rabies vaccines for wild animals in an attempt to eradicate the disease...
  22. Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..In this proposal we will use a model system to determine whether raising uric acid levels may provide a safe, natural means of preventing secondary nerve cell death and improving the outcome of spinal cord injury. ..
  23. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..abstract_text> ..
  24. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  25. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  26. Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    DOUGLAS HOOPER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  28. Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2008
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  30. Role of Pet Animals as Reservoirs for MRSA in Households
    Daniel Morris; Fiscal Year: 2008
    ..It is a fact that humans and animals share germs, such as MRSA. Recognizing this fact and discovering ways to minimize its impact is imperative to the protection of public health: both human and animal. ..
  31. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  32. Oral Vaccine to Inhalation Rabies
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 2, the AdC68rab.gp vaccine will be tested in a non-human primate rabies virus challenge model. ..
  33. Astrocytes and Restricted HIV-1 Replication
    Matthias Schnell; Fiscal Year: 2006
    ..Thus, these complementary approaches will be utilized to analyze, on molecular levels, the mechanisms of HIV-1 reservoirs and persistence in human astrocytes. [unreadable] [unreadable]..
  34. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 3, we are proposing experiments in non-human primates to test the vaccine for efficacy in pre- and post-challenge vaccination experiments with and without concomitant application of RIG. [unreadable] [unreadable]..
  35. A novel rhabdovirus-based anthrax vaccine
    Matthias Schnell; Fiscal Year: 2007
    ..The general concept, if proven successful, may also lead to a general technique for developing more effective vaccines for other important pathogens. [unreadable] [unreadable] [unreadable]..
  36. Developing Avirulent Rabies Virus Vaccines
    Zhen F Fu; Fiscal Year: 2010
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  37. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2010
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. The experiments in this proposal are designed to test the hypothesis that replication-deficient RVs would ..
  38. Replication-deficient rabies vectors against rabies infection
    James McGettigan; Fiscal Year: 2009
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. The experiments in this proposal are designed to test the hypothesis that replication-deficient RVs would ..
  39. RABIES VIRUS-BASED VECTORS AS AN HIV-1 VACCINE
    Matthias Schnell; Fiscal Year: 2008
    ..Thus, we will pursue several complementary approaches designed to further improve our HIV-1 vaccines, study their anti-HIV directed immunogenicity in detail, and test their efficacy in the rhesus macaque model system. ..
  40. Immune Responses To AAV-Mediated FIX Gene Transfer
    Hildegund Ertl; Fiscal Year: 2008
    ..The projects will be supported by an Administrative Core, which will provide the needed oversight, and a Vector Core, which will provide the investigators with purified and quality controlled vectors. ..
  41. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2008
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  42. Astrocytes and Restricted HIV-1 Replication
    Matthias Schnell; Fiscal Year: 2007
    ..Thus, these complementary approaches will be utilized to analyze, on molecular levels, the mechanisms of HIV-1 reservoirs and persistence in human astrocytes. [unreadable] [unreadable]..
  43. HIV-1 Vaccine Based on Chimp Serotypes of Adenovirus
    Hildegund Ertl; Fiscal Year: 2008
    ..Studies by HVTN will be complemented by studies of Project 3, which will assess in human volunteers the quality of vaccine-induced gag-specific T cell responses in relationship to pre-existing immunity to the vaccine carrier. ..
  44. Immune Responses To AAV-Mediated FIX Gene Transfer
    Hildegund Ertl; Fiscal Year: 2007
    ..The projects will be supported by an Administrative Core, which will provide the needed oversight, and a Vector Core, which will provide the investigators with purified and quality controlled vectors. ..
  45. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
    ....
  46. CORE--VECTOR
    Jaap Goudsmit; Fiscal Year: 2005
    ..To coordinate preclinical toxicology studies under GLP conditions and prepare IND applications to support the initiation of phase I and phase II clinical trials...
  47. Rabies Virus-Based Vectors as an HIV - 1 Vaccine
    Matthias Schnell; Fiscal Year: 2005
    ..Thus, we will pursue several complementary approaches designed to further improve our HIV-1 vaccines, study their anti-HIV directed immunogenicity in detail, and test their efficacy in the rhesus macaque model system. ..
  48. Prime/Boost Immunization against HIV-1 by Viral Vectors
    Matthias Schnell; Fiscal Year: 2003
    ....
  49. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2003
    ..If the further attenuated rabies viruses no longer causes diseases in animals at any age and by any route of inoculation, yet remain immunoqenic, they can be developed as modified live rabies vaccines for humans and animals.
  50. RABIES VIRUS-BASED VECTORS AS AN HIV-1 VACCINE
    Matthias Schnell; Fiscal Year: 2003
    ..After detectable immunity is induced by the vaccine, the immunized monkeys will be challenged intravaginally with SIVmac251. Thus, complementary approaches will be used in vaccine development. ..
  51. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2002
    ..If the further attenuated rabies viruses no longer causes diseases in animals at any age and by any route of inoculation, yet remain immunoqenic, they can be developed as modified live rabies vaccines for humans and animals.
  52. CANCER VACCINE TO P53
    Hildegund Ertl; Fiscal Year: 2001
    ....
  53. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2004
    ..If the further attenuated rabies viruses no longer causes diseases in animals at any age and by any route of inoculation, yet remain immunoqenic, they can be developed as modified live rabies vaccines for humans and animals.
  54. Oral Vaccine to Inhalation Rabies
    Hildegund Ertl; Fiscal Year: 2004
    ..In aim 2, the AdC68rab.gp vaccine will be tested in a non-human primate rabies virus challenge model. ..
  55. Killed Rhabdoviruses as Novel Anthrax Vaccines
    Matthias Schnell; Fiscal Year: 2006
    ..Lastly, Anthrax challenge experiments of the most promising constructs in mice will indicate if the inducted responses are protective against Anthrax infection. ..
  56. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  57. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2005
    ..abstract_text> ..
  58. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..abstract_text> ..
  59. CANCER VACCINES TO HPV-16 ASSOCIATED TUMOR
    Hildegund Ertl; Fiscal Year: 1999
    ..In case the applicant's hypothesis is correct, data gathered within the realm of this application will serve as the basis for a clinical Phase I trial. ..
  60. CANCER VACCINE TO P53
    Hildegund Ertl; Fiscal Year: 2000
    ....
  61. Prime-boost regimens for adenoviral vaccines to HIV-1
    Hildegund Ertl; Fiscal Year: 2004
    ..abstract_text> ..
  62. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 1999
    ....
  63. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  64. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2000
    ....
  65. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2008
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  66. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2009
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  67. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  68. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2003
    ..abstract_text> ..
  69. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2004
    ..abstract_text> ..
  70. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2007
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  71. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  72. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  73. Oral Vaccine to Inhalation Rabies
    Hildegund Ertl; Fiscal Year: 2005
    ..In aim 2, the AdC68rab.gp vaccine will be tested in a non-human primate rabies virus challenge model. ..
  74. E1-deleted adenoviral vectors for oral immunization
    Hildegund Ertl; Fiscal Year: 2004
    ..In aim 4, we will determine the tropism of the simian and human Ad recombinants upon oral application emphasizing localization of and cytokine production by transduced antigen presenting cells (APCs). ..
  75. CANCER VACCINES TO HPV-16 ASSOCIATED TUMOR
    Hildegund Ertl; Fiscal Year: 2001
    ..In case the applicant's hypothesis is correct, data gathered within the realm of this application will serve as the basis for a clinical Phase I trial. ..
  76. Mucosal Vaccine to HIV-1 Gag
    Hildegund Ertl; Fiscal Year: 2002
    ..In the third aim, we will test a prime-boost regimen using DNA vaccines, expressing Gag for systemic priming combined with the adenoviral recombinants for systemic or intranasal booster immunization. ..
  77. TRAINING PROGRAM IN THE IMMUNOBIOLOGY OF VACCINES
    Hildegund Ertl; Fiscal Year: 2007
    ..All of the course work will take place at The Wistar Institute. ..
  78. HIV-1 Vaccine-Induced CD8+ Memory Cells
    Hildegund Ertl; Fiscal Year: 2003
    ..The role of the two different memory CD8+ T cell populations in limiting propagation of the vaccinia gag recombinant virus will be tested by adoptive transfer experiments. ..