rabies vaccines

Summary

Summary: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.

Top Publications

  1. ncbi Immunogenicity of purified vero cell rabies vaccine used in the treatment of fox-bite victims in India
    I S Matha
    District Hospital, Nashik, India
    Clin Infect Dis 40:611-3. 2005
  2. ncbi Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
  3. ncbi Overview, prevention, and treatment of rabies
    Andrea Julia Nigg
    Department of Pharmacy Services, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    Pharmacotherapy 29:1182-95. 2009
  4. ncbi Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis
    Zélie Lardon
    INSERM, U657 and Institut Pasteur, PhEMI, Paris, France
    PLoS Negl Trop Dis 4:e723. 2010
  5. ncbi Rabies trend in China (1990-2007) and post-exposure prophylaxis in the Guangdong province
    Han Si
    1Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, PR China
    BMC Infect Dis 8:113. 2008
  6. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
  7. ncbi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
  8. ncbi Safety and efficacy of the oral rabies vaccine SAG2 in raccoon dogs
    F Cliquet
    AFSSA Nancy, WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Community Reference Laboratory for Rabies Serology, Domaine de Pixerecourt, Malzeville, France
    Vaccine 24:4386-92. 2006
  9. ncbi A quantitative indirect ELISA to monitor the effectiveness of rabies vaccination in domestic and wild carnivores
    A Servat
    AFSSA Nancy, Laboratoire d Etudes et de Recherches sur la Rage et la Pathologie des Animaux Sauvages, Domaine de Pixerecourt, B P 9 54220 Malzéville, France
    J Immunol Methods 318:1-10. 2007
  10. ncbi Human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, between 2002 and 2006
    Filipe Dantas-Torres
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Soc Bras Med Trop 40:617-21. 2007

Research Grants

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
  2. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
  3. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
  4. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2003
  5. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
  6. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
  7. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
  8. Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    DOUGLAS HOOPER; Fiscal Year: 2007
  9. Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?
    DOUGLAS HOOPER; Fiscal Year: 2007
  10. Developing Avirulent Rabies Virus Vaccines
    Zhen F Fu; Fiscal Year: 2010

Detail Information

Publications294 found, 100 shown here

  1. ncbi Immunogenicity of purified vero cell rabies vaccine used in the treatment of fox-bite victims in India
    I S Matha
    District Hospital, Nashik, India
    Clin Infect Dis 40:611-3. 2005
    ..Maximum antibody titers determined using a rapid fluorescent focus inhibition test were 25 IU, < or =90 days after the first vaccination and were 30 IU on day 1050 after booster vaccination...
  2. ncbi Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
    ..To quantify the public health and economic burden of endemic canine rabies in Africa and Asia...
  3. ncbi Overview, prevention, and treatment of rabies
    Andrea Julia Nigg
    Department of Pharmacy Services, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    Pharmacotherapy 29:1182-95. 2009
    ..The recently developed Milwaukee Protocol added induction of therapeutic coma to supportive care measures and antivirals; however, its use has shown inconsistent outcomes...
  4. ncbi Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis
    Zélie Lardon
    INSERM, U657 and Institut Pasteur, PhEMI, Paris, France
    PLoS Negl Trop Dis 4:e723. 2010
    ....
  5. ncbi Rabies trend in China (1990-2007) and post-exposure prophylaxis in the Guangdong province
    Han Si
    1Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, PR China
    BMC Infect Dis 8:113. 2008
    ....
  6. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
    ..Prompt rabies PEP combining wound care, infiltration of RIG into and around the wound, and multiple doses of rabies cell-culture vaccine continue to be highly effective in preventing human rabies...
  7. ncbi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
    ..Little data exist about the spatial distribution of the risk for travelers of being injured by a potentially rabid animal...
  8. ncbi Safety and efficacy of the oral rabies vaccine SAG2 in raccoon dogs
    F Cliquet
    AFSSA Nancy, WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Community Reference Laboratory for Rabies Serology, Domaine de Pixerecourt, Malzeville, France
    Vaccine 24:4386-92. 2006
    ..All 28 vaccinated animals developed high rabies neutralizing antibody titres. After virulent challenge, all 11 controls succumbed to rabies, whereas all 28 vaccinates survived...
  9. ncbi A quantitative indirect ELISA to monitor the effectiveness of rabies vaccination in domestic and wild carnivores
    A Servat
    AFSSA Nancy, Laboratoire d Etudes et de Recherches sur la Rage et la Pathologie des Animaux Sauvages, Domaine de Pixerecourt, B P 9 54220 Malzéville, France
    J Immunol Methods 318:1-10. 2007
    ....
  10. ncbi Human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, between 2002 and 2006
    Filipe Dantas-Torres
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Soc Bras Med Trop 40:617-21. 2007
    ....
  11. ncbi Knowledge, attitudes, and practices of French travelers from Marseille regarding rabies risk and prevention
    Matthias Altmann
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, Marseille, France
    J Travel Med 16:107-11. 2009
    ..To assess the awareness of the mode of rabies transmission, travel-associated rabies risk, and adequate preventive measures among French travelers...
  12. ncbi Rabies update for travel medicine advisors
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Clin Infect Dis 37:96-100. 2003
    ..Safe and effective tissue-culture rabies vaccines and human and equine rabies immunoglobulins (HRIG and ERIG) are not readily available in many regions where ..
  13. ncbi Transmission dynamics and economics of rabies control in dogs and humans in an African city
    J Zinsstag
    Swiss Tropical Institute, PO Box, CH 4002 Basle, Switzerland
    Proc Natl Acad Sci U S A 106:14996-5001. 2009
    ..Beyond a time-frame of 7 years, it appears to be more cost-effective to combine parenteral dog-vaccination campaigns with human PEP compared to human PEP alone...
  14. ncbi Oral vaccination of mice with adenoviral vectors is not impaired by preexisting immunity to the vaccine carrier
    Z Q Xiang
    The Wistar Institute. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:10780-9. 2003
    ..Oral priming-boosting regimens with either heterologous or homologous adenoviral vectors used sequentially increased both mucosal and systemic antibody titers to rabies virus [corrected]..
  15. ncbi Genetic characterisation of attenuated SAD rabies virus strains used for oral vaccination of wildlife
    Lutz Geue
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
    Vaccine 26:3227-35. 2008
    ..Our data also supports the idea of a possible recombination that had occurred during the derivation of the European branch of SAD viruses. If confirmed, this recombination event would be the first one reported among RABV vaccine strains...
  16. ncbi Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
    Kalifa Bojang
    Medical Research Council Laboratories, Banjul, The Gambia
    Hum Vaccin 5:242-7. 2009
    ..This study provides the first indication of the long-term safety and persistence of anti-CS and anti-HBs antibodies of the RTS,S vaccine candidate in combination with the novel AS02 Adjuvant System...
  17. ncbi Characterization of Russian rabies virus vaccine strain RV-97
    A Metlin
    Department of Animal Diseases and Food Safety Research, Virology, Mustialankatu 3, FI 00790 Helsinki, Finland
    Virus Res 132:242-7. 2008
    ..It also contains several unique amino acid changes in known immunodominant sites of G and P proteins...
  18. ncbi Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus
    Milosz Faber
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 106:11300-5. 2009
    ....
  19. ncbi Cost-efficient vaccination of foxes (Vulpes vulpes) against rabies and the need for a new baiting strategy
    T Selhorst
    Federal Research Centre for Virus Diseases of Animals, WHO Collaborating Centre for rabies in Central and Eastern Europe, Institute for Epidemiology, Seetr 55, D 16868, Wusterhausen, Germany
    Prev Vet Med 51:95-109. 2001
    ..We concluded that distribution of baits in June was optimal given that the durability of baits is above a threshold of 7 days...
  20. ncbi Acceptance of baits for delivery of oral rabies vaccine to raccoons
    R C Rosatte
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Rabies Research and Development Unit, Trent University, Science Complex, P O Box 4840, Peterborough, Ontario K9J 8N8, Canada
    J Wildl Dis 37:730-9. 2001
    ..Puncture and impact testing of blister packs in baits suggested that they would adequately serve as a vehicle to contain oral rabies vaccine for delivery to raccoons via baits...
  21. ncbi Experimental rabies vaccines for humans
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Vaccine Center, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, JAH 466, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 9:1177-86. 2010
    ..The usefulness of human rabies vaccines is hampered by high cost, complicated vaccination regimens and lack of compliance, especially in areas of ..
  22. ncbi Rabies in wildlife in Latvia
    Sanita Vanaga
    Department of Virology, National Veterinary Laboratory, Latvia
    Vector Borne Zoonotic Dis 3:117-24. 2003
    ..To successfully eradicate the wildlife reservoirs, the national rabies eradication program must be continued, and it may need to be intensified...
  23. ncbi Evaluation of mass vaccination campaign coverage against rabies in dogs in Tunisia
    L Touihri
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Zoonoses Public Health 58:110-8. 2011
    ..The achieved vaccination coverage should be estimated after random visits in many parts of the country and by checking valid vaccination certificates...
  24. ncbi [The first case of rabies in Sweden in 26 years. Inform travellers abroad about risks and treatment following suspected infection]
    J Hojer
    Infektionskliniken, Södersjukhuset Huddinge Universitetssjukhus
    Lakartidningen 98:1216-20. 2001
    ..Tourists must be informed of the vital importance of post-exposure prophylaxis after suspected infection...
  25. ncbi Rabies in Estonia: situation before and after the first campaigns of oral vaccination of wildlife with SAG2 vaccine bait
    Enel Niin
    Veterinary and Food Board of Estonia VFB, Väike Paala Street 3, 11415 Tallinn, Estonia, France
    Vaccine 26:3556-65. 2008
    ..5%) occurred within the vaccinated area. Only 17 cases were diagnosed between 1 June and 31 December 2006. In 2007, by the end of May, only two rabies cases have been registered...
  26. ncbi Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland
    P Bugnon
    Institute of Cell Biology, Swiss Federal Institute of Technology, , Switzerland
    J Vet Med B Infect Dis Vet Public Health 51:433-7. 2004
    ..The theoretical implication of the successful elimination of fox rabies in Switzerland in spite of a relatively low overall proportion of VNA-positive animals is discussed...
  27. ncbi Vaccinating the vampire bat Desmodus rotundus against rabies
    M F Almeida
    School of Medicine, University of São Paulo and LIM01 HCFMUSP, Brazil Laboratory of Rabies, Zoonosis Control Center of São Paulo City, Brazil
    Virus Res 137:275-7. 2008
    ..A dose of 10(5.0) MICLD(50) rabies virus was used by intramuscular route to challenge the bats postvaccination. The survival proportion in the three groups after the challenge was 71.4%, 71.4% and 100%...
  28. ncbi The global fight against rabies
    Talha Burki
    Lancet 372:1135-6. 2008
  29. ncbi Safety and immunogenicity of two freeze-dried Vero cell rabies vaccines for human use in post-exposure prophylaxis
    Ling yun Wang
    Beijing Center for Diseases Prevention and Control, Beijing 100013, China
    Vaccine 29:2679-81. 2011
    ..basis for human rabies vaccination in China, the safety and immunogenicity of two freeze-dried Vero cell rabies vaccines for human use were assessed...
  30. ncbi [Human rabies in France in 2004: update and management]
    H Peigue-Lafeuille
    Service de Virologie, Faculte de Medecine, 28, Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    Med Mal Infect 34:551-60. 2004
    ..People traveling abroad, particularly to Africa, are warned not to approach unknown animals (especially dogs) nor to try to import them, and are advised to comply with vaccinal recommendations for travelers, particularly for toddlers...
  31. ncbi Comparative immunogenicity and efficacy studies with oral rabies virus vaccine SAD P5/88 in raccoon dogs and red foxes
    P Schuster
    Institute of Epidemiological Diagnostics, Federal Research Centre for Virus Diseases of Animals, Wusterhausen, Germany
    Acta Vet Hung 49:285-90. 2001
    ..Also all control foxes succumbed to rabies. Our findings demonstrate that SAD P5/88 is not only an effective vaccine for oral vaccination of foxes but also for that of raccoon dogs...
  32. ncbi Inter-laboratory trial to evaluate the reproducibility of a new ELISA to detect rabies antibodies in vaccinated domestic and wild carnivores
    A Servat
    WHO collabarating Centre for Research and Management in Zoonoses Control, Community Reference Institute for Rabies Serology, Technopole Agricole et Vétérinaire, BP 40009, 54220 Malzéville cedex, France
    Biologicals 36:19-26. 2008
    ....
  33. ncbi Characterization of human rabies virus vaccine strain in China
    Jialiang Du
    Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control, Xuan Wu District, Beijing, China
    Virus Res 135:260-6. 2008
    ..In addition, some mutations and new functional regions were discovered that are presumed crucial to the function of leader region and L protein. There is an equal role for all five genes in the phylogenetics of rabies virus...
  34. ncbi Efficacy and bait acceptance of vaccinia vectored rabies glycoprotein vaccine in captive foxes (Vulpes vulpes), raccoon dogs (Nyctereutes procyonoides) and dogs (Canis familiaris)
    F Cliquet
    AFSSA NANCY Laboratory of Research on Rabies and Wildlife Diseases, WHO Collaborating Centre for Research and Management in Zoonoses Control, Technopole Agricole et Vétérinaire, B P 40009, 54220 Malzeville, France
    Vaccine 26:4627-38. 2008
    ..The square RABORAL V-RG bait, however, was consumed more effectively than the rectangular RABORAL V-RG bait by the raccoon dog...
  35. ncbi Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine
    Thavachai Kamoltham
    Provincial Health Department, Petchabun Province, Queen Saovabha Memorial Institute of the Thai Red Cross Society, Department of Medicine, Chulalongkorn University, Bangkok, Thailand
    Vaccine 20:3272-6. 2002
    ..The modified TRC-ID method induces adequate levels of neutralizing antibodies, protects humans bitten by rabid dogs and results in significant savings in vaccine and travel costs...
  36. ncbi Factors influencing the antibody response of dogs vaccinated against rabies
    Lorna J Kennedy
    Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Vaccine 25:8500-7. 2007
    ....
  37. ncbi Evaluating the cost-effectiveness of rabies post-exposure prophylaxis: a case study in Tanzania
    Eunha Shim
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06510, USA
    Vaccine 27:7167-72. 2009
    ..Moreover, PEP remains "very cost-effective" provided that at least 1% of doses are administered to people who were actually exposed to rabies...
  38. ncbi Ovine anti-rabies antibody production and evaluation
    el Rashdy M Redwan
    Protein Research Department, Genetic Engineering and Biotechnology Research Institute, Mubarak City for Scientific Research and Technology Applications, Alexandria, Egypt
    Comp Immunol Microbiol Infect Dis 32:9-19. 2009
    ..Sheep's IgG has low immunogenic effect than human and horse antibodies when injected into the mouse. Pure concentrated ovine antibody may serve as a possible alternative to currently available anti-rabies human or equine immunoglobulin...
  39. ncbi Comparison of saftey and immunogenicity of purified chick embryo cell rabies vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) using the Thai Red Cross intradermal regimen at a dose of 0.1 ML
    Shampur N Madhusudana
    Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Hum Vaccin 2:200-4. 2006
    Intradermal (ID) vaccination with modern cell culture rabies vaccines is a means to significantly reduce the cost of post-exposure prophylaxis as compared to intramuscular vaccination...
  40. ncbi Rapid clearance of SAG-2 rabies virus from dogs after oral vaccination
    L A Orciari
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, Rabies Section, Mailstop G 33, Atlanta, GA 30333, USA
    Vaccine 19:4511-8. 2001
    ..Attenuated rabies viruses, such as SAG-2, replicate in local tissues of the oral cavity and can be cleared relatively quickly, without viral excretion, leading to protective immunity against the disease...
  41. ncbi Comparison of antibody responses after vaccination with two inactivated rabies vaccines
    J M Minke
    Merial SAS, 254, rue Marcel Merieux, 69007 Lyon, France
    Vet Microbiol 133:283-6. 2009
    ..and subcutaneously vaccinated with a single dose of one of two commercially available monovalent inactivated rabies vaccines: RABISIN (Merial, France) (group A) and NOBIVAC Rabies (Intervet International) (group B)...
  42. ncbi Factors affecting the serological response of dogs and cats to rabies vaccination
    K L Mansfield
    Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Surrey KT15 3NB
    Vet Rec 154:423-6. 2004
    ..In dogs, all these factors, except sex, had highly significant (P < 0.001) effects on the test failure rate, and in cats all the factors had a significant effect (P < 0.05)...
  43. ncbi Landscape genetics of raccoons (Procyon lotor) associated with ridges and valleys of Pennsylvania: implications for oral rabies vaccination programs
    J Jeffrey Root
    United States Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado 80521, USA
    Vector Borne Zoonotic Dis 9:583-8. 2009
    ..These results may be of value for future ORV efforts in Pennsylvania and other eastern states with similar landscapes...
  44. ncbi Peptide mimotopes of rabies virus glycoprotein with immunogenic activity
    Mehdi Houimel
    Laboratoire d Immunopathologie Vaccinologie et Génétique Moléculaire, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Vaccine 27:4648-55. 2009
    ..The RABVG site III mimotope (C-KRDSTW-C) would provide a new and promising concept for the development of rabies vaccine...
  45. ncbi Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines
    Richard Franka
    Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Vaccine 27:7149-55. 2009
    ..Reduced vaccine schedules provided efficacious intervention, regardless of the total number of vaccine doses administered...
  46. ncbi Postexposure rabies prophylaxis completed in 1 week: preliminary study
    Prapimporn Shantavasinkul
    Queen Saovabha Memorial Institute, The Thai Red Cross Society World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention, Bangkok, Thailand
    Clin Infect Dis 50:56-60. 2010
    ..Reducing the number of clinic visits would not only reduce costs for the patient but may also help increase compliance to receive complete PEP. We made an effort to develop PEP completed in 1 week...
  47. ncbi Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
    ..This robust microassay will improve our understanding of the protective humoral immunity that current rabies vaccines confer against emerging lyssaviruses, and will be applicable to surveillance studies, thus helping to control ..
  48. ncbi Transmission dynamics and prospects for the elimination of canine rabies
    Katie Hampson
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
    PLoS Biol 7:e53. 2009
    ..Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal...
  49. ncbi Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine
    D J Briggs
    College of Veterinary Medicine, Kansas State University, USA
    Bull World Health Organ 78:693-8. 2000
    ..introduction of tissue culture vaccines for rabies has dramatically improved the immunogenicity and safety of rabies vaccines, they are often prohibitively expensive for developing countries...
  50. ncbi Human benefits of animal interventions for zoonosis control
    Jakob Zinsstag
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 13:527-31. 2007
    ....
  51. ncbi Evaluation of state-provided postexposure prophylaxis against rabies in Florida
    Lisa Conti
    Florida Department of Health, Tallahassee, USA
    South Med J 95:225-30. 2002
    ..Inappropriate administration of PEP and cost can be reduced by establishing a system of after-the-fact review of every episode of PEP with timely feedback to providers...
  52. ncbi Prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoprotein
    Rongliang Hu
    Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Science, 1068 Qinglong Road, Changchun, Jilin 130062, PR China
    Microbes Infect 8:1090-7. 2006
    ..Although several genetically engineered rabies vaccines have been developed, few have been licensed for use, principally due to biosafety concerns or due to poor ..
  53. ncbi Human rabies in China
    Yong-Zhen Zhang
    Emerg Infect Dis 11:1983-4. 2005
  54. ncbi Multicenter comparative study of a new ELISA, PLATELIA RABIES II, for the detection and titration of anti-rabies glycoprotein antibodies and comparison with the rapid fluorescent focus inhibition test (RFFIT) on human samples from vaccinated and non-vacci
    M Feyssaguet
    Bio Rad, 3 boulevard Raymond Poincaré, 92430 Marnes La Coquette, France
    Vaccine 25:2244-51. 2007
    ..4%. This study indicates that this new ELISA test is as sensitive and specific as the current standardized reference method. The method is simple, safe, rapid and can be considered as a useful alternative to the neutralisation test...
  55. ncbi A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries
    S Cleaveland
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Vaccine 21:1965-73. 2003
    Despite the availability of safe and effective rabies vaccines, the incidence of dog rabies has been increasing throughout much of sub-Saharan Africa...
  56. ncbi Cost of distributing oral raccoon-variant rabies vaccine in Ohio: 1997-2000
    Pirouz Foroutan
    Department of Agricultural, Environmental, and Development Economics, College of Food, Agricultural, and Environmental Sciences, The Ohio State University. Columbus, OH 43210, USA
    J Am Vet Med Assoc 220:27-32. 2002
    ..In addition, accurately measured distribution costs can be used to perform an economic cost-benefit analysis for an ORV program...
  57. ncbi An epidemiological description of human-hazardous incidents caused by nonhematophagous bats in Brazil, 2002-2003
    Julia C M Brazuna
    Center for Zoonosis Control, Public Health Department of the Municipality of Campo Grande, Av Filinto Muller, 1601, Campo Grande, MS, Brazil
    Prev Vet Med 77:137-44. 2006
    ..The results revealed the need for improving the current human rabies control program in order to reduce noncompliance rates and to decrease the occurrence of flaws in patients' records and in the provision of health care...
  58. ncbi Potential cost savings with terrestrial rabies control
    Sergio Recuenco
    Zoonoses Program, Bureau of Communicable Diseases Control, New York State Department of Health, Albany, New York 12237, USA
    BMC Public Health 7:47. 2007
    ..As an initial quantification of the potential cost savings for a control program, the collection of selected rabies cost data was pilot tested for five counties in New York State (NYS) in a three-year period...
  59. ncbi Human rabies exposures and postexposure prophylaxis in South Carolina, 1993-2002
    Jennifer McQuiston
    Angell Animal Medical Center, Boston, MA, USA
    Public Health Rep 121:197-202. 2006
    ..An accurate estimation of the incidence of PEP and an understanding of rabies epidemiology is important at the state level to allow for better public health planning...
  60. ncbi Canine rabies ecology in southern Africa
    John Bingham
    Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Emerg Infect Dis 11:1337-42. 2005
    ..The implications for understanding rabies ecology and control are reviewed, as are previous studies on rabies ecology in African canids...
  61. ncbi Rabies surveillance in the United States during 2003
    John W Krebs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    J Am Vet Med Assoc 225:1837-49. 2004
    ..The California and Puerto Rico cases were the result of infections with bat and dog/mongoose rabies virus variants, respectively, and each patient had a history of a bite...
  62. ncbi Comparative evaluation of specific ELISA and RFFIT antibody assays in the assessment of dog immunity against rabies
    C Bahloul
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, Tunisia
    Epidemiol Infect 133:749-57. 2005
    ..A seroconversion threshold of 0.5 IU/ml should be cautiously considered and a higher threshold (1 IU/ml) could be more appropriate in the evaluation of rabies immunity in the field in order to marginalize the interfering factors...
  63. ncbi Rabies and other lyssavirus diseases
    M J Warrell
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet 363:959-69. 2004
    ..Meanwhile, enormous challenges remain in the control of animal rabies and the provision of accessible, appropriate human prophylaxis worldwide...
  64. ncbi Canine vaccination--providing broader benefits for disease control
    Sarah Cleaveland
    Wildlife and Emerging Disease Section, Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vet Microbiol 117:43-50. 2006
    ..The tools and delivery systems are all available--all that is needed is the political will to free the world from the ongoing tragedy of these diseases...
  65. ncbi Canine ecology and socioeconomic factors associated with dogs unvaccinated against rabies in a Mexican city across the US-Mexico border
    Maricela Flores-Ibarra
    Instituto de Investigaciones en Ciencias Veterinarias, , , CP 21100 Mexicali, Baja California, Mexico
    Prev Vet Med 62:79-87. 2004
    ..Crossbred dogs had 1.5 times higher risk of nonvaccination compared to purebred dogs. The canine-ecology structure is similar to that in regions were rabies is endemic...
  66. ncbi Vaccination with rabies to study the humoral and cellular immune response to a T-cell dependent neoantigen in man
    D M C Brinkman
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Immunol 23:528-38. 2003
    ..Five patients diagnosed with a combined immunodeficiency were vaccinated using the same protocol and showed a number of abnormalities, either in the humoral or the cellular immune response to the rabies neoantigen...
  67. ncbi Oral vaccination of dogs with recombinant rabies virus vaccines
    Charles E Rupprecht
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, Rabies Unit, Mailstop G 33, Atlanta, GA 30333, USA
    Virus Res 111:101-5. 2005
    ....
  68. ncbi Rabies postexposure prophylaxis, New York, 1995-2000
    Jesse D Blanton
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1921-7. 2005
    ..Bats accounted for 30% of exposures, more than any other group of animals; consequently, bats have replaced raccoons as the leading rabies exposure source to humans in this area...
  69. ncbi Rabies and rabies-related viruses: a modern perspective on an ancient disease
    F Cliquet
    Laboratory of Research on Rabies and Wildlife Diseases, OIE (World Organisation for Animal Health) Reference Laboratory for Rabies, World Health Organization Collaborating Centre for Research and Management in Zoonoses Control, , France
    Rev Sci Tech 23:625-42. 2004
    ..Rabies is still a significant public health problem, particularly in areas where canine rabies is still endemic, such as countries in Africa and Asia...
  70. ncbi Human rabies prophylactics: the French experience
    Y Rotivel
    Institut Pasteur, 25 rue du, Docteur Roux, France
    Vaccine 21:710-5. 2003
    ..Data on rabies cases in animals, rabies cases in humans, PET, surveillance of exposures to baits and oral vaccines for the wild fauna, and exposures outside the French territory will be successively considered and discussed...
  71. ncbi Kinetics of humoral immune response after rabies VR-G oral vaccination of captive fox cubs (Vulpes vulpes) with or without maternally derived antibodies against the vaccine
    E Blasco
    Agence Francaise de Securite Sanitaire des Aliments, AFSSA Nancy, Domaine de Pixerecourt, B P 9, F 54220, Malzeville, France
    Vaccine 19:4805-15. 2001
    ..Provided a vaccine-bait suitable for such young cubs exists, oral vaccination at den entrances with VR-G is a feasibility...
  72. ncbi [An epidemiological study of rabies virus in domestic dogs, cats and wildlife and the immunogenicity study for rabies vaccines derived from different cell cultured virus strains]
    Guan mu Dong
    National Institute for the Control of Parmaceutical and Biological Products, Beijing 100050, China
    Bing Du Xue Bao 23:417-23. 2007
    ..The rabies vaccines which prepared from aG and CTN strains have already been produced successfully in China...
  73. ncbi Rabies postexposure prophylaxis, Marseille, France, 1994-2005
    Philippe Gautret
    Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, France
    Emerg Infect Dis 14:1452-4. 2008
    ..Most injuries were associated with indigenous dogs; rabies vaccine was overprescribed. We suggest that the World Health Organization guidelines be adapted for countries free of terrestrial mammal rabies...
  74. ncbi Rabies control in rural Africa: evaluating strategies for effective domestic dog vaccination
    M Kaare
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vaccine 27:152-60. 2009
    ..These results suggest that rabies control is logistically feasible across most of the developing world and that the annual costs of effective vaccination campaigns in Tanzania are likely to be affordable...
  75. ncbi Inferior rabies vaccine quality and low immunization coverage in dogs ( Canis familiaris) in China
    R L Hu
    Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, Changchun, China
    Epidemiol Infect 136:1556-63. 2008
    ..Results also indicated that the quality of rabies vaccines for animal use did not satisfy all of the requirements for an efficacious vaccine capable of fully ..
  76. ncbi Failure of multiple-site intradermal postexposure rabies vaccination in patients with human immunodeficiency virus with low CD4+ T lymphocyte counts
    T Tantawichien
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Infect Dis 33:E122-4. 2001
    ....
  77. ncbi Postexposure treatment and animal rabies, Ontario, 1958-2000
    Christopher P Nunan
    Ontario Ministry of Natural Resources, Peterborough, Ontario, Canada
    Emerg Infect Dis 8:214-7. 2002
    ..Introducing HDCV led to an immediate doubling of treatments. Both animal rabies and human treatments declined rapidly after the vaccination program was introduced, but human treatments have leveled off at approximately 1,000 per year...
  78. ncbi Owner valuation of rabies vaccination of dogs, Chad
    Salome Dürr
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 14:1650-2. 2008
    ..Owners would pay approximately 400-700 CFA francs (US $0.78-$1.36)/animal. To vaccinate >or=70% of dogs, and thus interrupt rabies transmission, health officials should substantially subsidize these vaccinations...
  79. ncbi Cost effectiveness of rabies post exposure prophylaxis in the United States
    Praveen Dhankhar
    Division of Emerging Infections and Surveillance Services, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS D59, Atlanta, GA 30333, United States
    Vaccine 26:4251-5. 2008
    ..The uncertainty caused by the wide range of cost effectiveness can only be resolved through analysis of data describing rabies transmission risk in a variety of scenarios...
  80. ncbi Use of rabies vaccines after reconstitution and storage
    Pakamatz Khawplod
    Queen Saovabha Memorial Institutes, Thai Red Cross Society and Department of Medicine, King Chulalongkorn University Hospital, Bangkok, Thailand
    Clin Infect Dis 34:404-6. 2002
    ..The 90-day booster dose mandated in the current intradermal regimen may not be necessary if the day 28 dose is doubled, eliminating 1 clinic visit at no additional cost in vaccine...
  81. ncbi Rabies surveillance in the United States during 2007
    Jesse D Blanton
    Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Coordinating Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Am Vet Med Assoc 233:884-97. 2008
    ..One human rabies case was reported from Minnesota during 2007. Although typing of the rabies virus variant in this case was not possible, an investigation of this case indicated a bat as the most likely source of exposure...
  82. ncbi Elimination of rabies from red foxes in eastern Ontario
    C D MacInnes
    Rabies Unit, Ontario Ministry of Natural Resources, Peterborough, Canada
    J Wildl Dis 37:119-32. 2001
    ..Persistence of terrestrial rabies, and ease of elimination, appeared to vary geographically, and probably over time. Ecological factors which enhance or reduce the long term survival of rabies in wild foxes are poorly understood...
  83. ncbi Economics of human and canine rabies elimination: guidelines for programme orientation
    K Bögel
    Division of Communicable Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 68:281-91. 1990
    ..On the other hand, for obvious ethical reasons, if attention is paid to improvement of post-exposure treatment, then the national authorities should consider a planning horizon close to 15 years...
  84. ncbi Direct and indirect costs of rabies exposure: a retrospective study in southern California (1998-2002)
    Stephanie A Shwiff
    National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, CO 80521 2154, USA
    J Wildl Dis 43:251-7. 2007
    ..About one third of the total cost for suspected human rabies exposure was attributed to indirect costs (e.g., lost wages, transportation, and day-care fees), most of which were not reimbursable to the patient...
  85. ncbi Human rabies postexposure prophylaxis during a raccoon rabies epizootic in New York, 1993 and 1994
    J D Wyatt
    University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Emerg Infect Dis 5:415-23. 1999
    ..g., raccoon saliva on pet dogs' and cats' fur) should also be considered...
  86. ncbi The elimination of raccoon rabies from Wolfe Island, Ontario: animal density and movements
    Rick Rosatte
    Ontario Ministry of Natural Resources, Rabies Research and Development Unit, Trent University, DNA Building, Peterborough, Ontario, Canada
    J Wildl Dis 43:242-50. 2007
    ..No cases have been detected since late January 2000 (to February 2007)...
  87. ncbi Public health impact of reemergence of rabies, New York
    Hwa Gan H Chang
    New York State Department of Health, Albany, New York 12237, USA
    Emerg Infect Dis 8:909-13. 2002
    ..To reduce rabid animals, exposures, and costs, oral vaccination of wildlife should also be considered...
  88. ncbi Experimental immunization of cats with a recombinant rabies-canine adenovirus vaccine elicits a long-lasting neutralizing antibody response against rabies
    R L Hu
    Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, PR China
    Vaccine 25:5301-7. 2007
    ..During the past decade, human rabies caused by cats has ranked the second highest in China. Several recombinant rabies vaccines have been developed for dogs. However, seldom have these vaccines been assessed or used in cats...
  89. ncbi A review of the economics of the prevention and control of rabies. Part 2: Rabies in dogs, livestock and wildlife
    M I Meltzer
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Pharmacoeconomics 14:481-98. 1998
    ..The economics of using oral vaccines to prevent raccoon rabies invading uninfected areas has yet to be examined...
  90. ncbi Failures of post-exposure rabies prophylaxis
    Henry Wilde
    Infectious Disease Unit, Department of Medicine, Division of Research and Development, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok 10330, Thailand
    Vaccine 25:7605-9. 2007
    ..True failures, where all was done according to WHO recommendations, are fortunately extremely rare. Presented are seven such deaths. Other examples of common management deviations that resulted in deaths are also shown...
  91. ncbi Dog ecology and demography information to support the planning of rabies control in Machakos District, Kenya
    P Kitala
    Department of Public Health, Pharmacology and Toxicology, University of Nairobi, PO Box 29053, Nairobi, Kenya
    Acta Trop 78:217-30. 2001
    ..The main implication for rabies control is that adequate vaccination coverage is unlikely to be achieved, even under optimal delivery, using the current strategy of annual vaccination of dogs older than 3 months...
  92. ncbi Assessing the costs and benefits of an oral vaccine for raccoon rabies: a possible model
    M I Meltzer
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 2:343-9. 1996
    ....
  93. ncbi Efficacy of rabies biologics against new lyssaviruses from Eurasia
    Cathleen A Hanlon
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road NE, Rabies Team, Atlanta, GA 30333, USA
    Virus Res 111:44-54. 2005
    ..The potential impact of these new lyssaviruses on human and domestic animal health and the impact on the putative bat reservoir populations will require further field and laboratory investigation...
  94. ncbi Bilateral neuro-retinitis following chick embryo cell anti-rabies vaccination--a case report
    Rohit Saxena
    Dr R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India
    BMC Ophthalmol 5:20. 2005
    ..The Optic nerve is rarely involved after sheep brain anti-rabies vaccination in the form of retrobulbar neuritis or papillitis. Bilateral neuroretinitis after chick embryo cell antirabies vaccination has not been reported...
  95. ncbi Rabies control in South and Southeast Asia
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, WHO Collaborating Center and Department of Medicine, King Chulalongkorn University Hospital, 1871 Rama IV Road, Bangkok 10330, Thailand
    Vaccine 23:2284-9. 2005
    ..There have been many new developments since publication of the last WHO rabies expert committee report in 1992 (new version in print)] and we will address those that have practical applicability...
  96. ncbi Prophylaxis against rabies
    Henry Wilde
    N Engl J Med 352:1608-10; author reply 1608-10. 2005
  97. ncbi Duration of immunity: an anamnestic response 14 years after rabies vaccination with purified chick embryo cell rabies vaccine
    Claudius Malerczyk
    Clinical Research and Medical Affairs, Novartis Vaccines, Marburg, Germany
    J Travel Med 14:63-4. 2007
  98. ncbi An immunogenicity, safety and post-marketing surveillance of a novel adsorbed human diploid cell rabies vaccine (Rabivax) in Indian subjects
    M K Sudarshan
    Department of Community Medicine and Rabies, Epidemiology Unit, Kempegowda Institute of Medical Sciences, Bangalore, India
    Hum Vaccin 4:275-9. 2008
    ..4%), swelling with induration (2.8%), fever and headache (1.4%). No serious adverse event was reported from the studies. In conclusion, Rabivax (adsorbed) is an immunogenic, safe and efficacious vaccine for rabies prophylaxis in humans...
  99. ncbi One-time intradermal DNA vaccination in ear pinnae one year prior to infection protects dogs against rabies virus
    Donald L Lodmell
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth Street, Hamilton, MT 59840, USA
    Vaccine 24:412-6. 2006
    ..m. with DNA that did not express the rabies virus G. The data suggest that a one-time i.d. rabies DNA vaccination into ear pinnae offers a new approach to facilitate control of endemic canine rabies in developing countries...
  100. ncbi Generation and evaluation of a recombinant modified vaccinia virus Ankara vaccine for rabies
    Jacqueline Weyer
    University of Pretoria, Department of Microbiology and Plant Pathology, Pretoria 0002, South Africa
    Vaccine 25:4213-22. 2007
    ..Recombinant MVA boosted humoral immune responses in these animals when administered peripherally, but not when administered orally...
  101. ncbi [Rabies virus antibody titers in dogs in Campo Grande, Mato Grosso do Sul State, during the anti-rabies campaign, 2003]
    Leonardo Rigo
    Secretaria Municipal de Saude de Campo Grande, Campo Grande, MS, Brazil
    Rev Soc Bras Med Trop 39:553-5. 2006
    ..It was found that 51.1% of the animals did not have protective titers. No correlation was found between vaccine application or multiple vaccinations and higher immune titers...

Research Grants87

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  2. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. We hypothesize that replication-deficient RVs will make excellent rabies PEPs...
  3. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  4. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2003
    ..II objectives of this research project are to extend safety and efficacy testing of these newly developed rabies vaccines in laboratory rodents and target animals (raccoon and skunk), and to choose a strain for which a master seed ..
  5. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..abstract_text> ..
  6. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  7. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  8. Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..Immunohistochemical, cellular and molecular techniques will be used to characterize the activity of CD4 T cells, vascular endothelial cells, and BBB-associated astrocytes as well as the changes that occur at the BBB during infection. ..
  9. Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..In this proposal we will use a model system to determine whether raising uric acid levels may provide a safe, natural means of preventing secondary nerve cell death and improving the outcome of spinal cord injury. ..
  10. Developing Avirulent Rabies Virus Vaccines
    Zhen F Fu; Fiscal Year: 2010
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  11. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
    ....
  12. CORE--VECTOR
    Jaap Goudsmit; Fiscal Year: 2005
    ..To coordinate preclinical toxicology studies under GLP conditions and prepare IND applications to support the initiation of phase I and phase II clinical trials...
  13. Oral Vaccine to Inhalation Rabies
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 2, the AdC68rab.gp vaccine will be tested in a non-human primate rabies virus challenge model. ..
  14. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2010
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. The experiments in this proposal are designed to test the hypothesis that replication-deficient RVs would ..
  15. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 3, we are proposing experiments in non-human primates to test the vaccine for efficacy in pre- and post-challenge vaccination experiments with and without concomitant application of RIG. ..
  16. Killed Rhabdoviruses as Novel Anthrax Vaccines
    Matthias Schnell; Fiscal Year: 2006
    ..Lastly, Anthrax challenge experiments of the most promising constructs in mice will indicate if the inducted responses are protective against Anthrax infection. ..
  17. A novel rhabdovirus-based anthrax vaccine
    Matthias Schnell; Fiscal Year: 2007
    ..The general concept, if proven successful, may also lead to a general technique for developing more effective vaccines for other important pathogens. ..
  18. Immune Responses To AAV-Mediated FIX Gene Transfer
    Hildegund Ertl; Fiscal Year: 2007
    ..The projects will be supported by an Administrative Core, which will provide the needed oversight, and a Vector Core, which will provide the investigators with purified and quality controlled vectors. ..
  19. Astrocytes and Restricted HIV-1 Replication
    Matthias Schnell; Fiscal Year: 2007
    ..Thus, these complementary approaches will be utilized to analyze, on molecular levels, the mechanisms of HIV-1 reservoirs and persistence in human astrocytes. ..
  20. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  21. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  22. CANCER VACCINE TO P53
    Hildegund Ertl; Fiscal Year: 2001
    ....
  23. Prime/Boost Immunization against HIV-1 by Viral Vectors
    Matthias Schnell; Fiscal Year: 2003
    ....
  24. RABIES VIRUS-BASED VECTORS AS AN HIV-1 VACCINE
    Matthias Schnell; Fiscal Year: 2003
    ..After detectable immunity is induced by the vaccine, the immunized monkeys will be challenged intravaginally with SIVmac251. Thus, complementary approaches will be used in vaccine development. ..
  25. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2004
    ..If the further attenuated rabies viruses no longer causes diseases in animals at any age and by any route of inoculation, yet remain immunoqenic, they can be developed as modified live rabies vaccines for humans and animals.
  26. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..abstract_text> ..
  27. Prime-boost regimens for adenoviral vaccines to HIV-1
    Hildegund Ertl; Fiscal Year: 2004
    ..abstract_text> ..
  28. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  29. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  30. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  31. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  32. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2007
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  33. E1-deleted adenoviral vectors for oral immunization
    Hildegund Ertl; Fiscal Year: 2004
    ..In aim 4, we will determine the tropism of the simian and human Ad recombinants upon oral application emphasizing localization of and cytokine production by transduced antigen presenting cells (APCs). ..
  34. Mucosal Vaccine to HIV-1 Gag
    Hildegund Ertl; Fiscal Year: 2002
    ..In the third aim, we will test a prime-boost regimen using DNA vaccines, expressing Gag for systemic priming combined with the adenoviral recombinants for systemic or intranasal booster immunization. ..
  35. CANCER VACCINES TO HPV-16 ASSOCIATED TUMOR
    Hildegund Ertl; Fiscal Year: 2001
    ..In case the applicant's hypothesis is correct, data gathered within the realm of this application will serve as the basis for a clinical Phase I trial. ..
  36. TRAINING PROGRAM IN THE IMMUNOBIOLOGY OF VACCINES
    Hildegund Ertl; Fiscal Year: 2007
    ..All of the course work will take place at The Wistar Institute. ..
  37. HIV-1 Vaccine-Induced CD8+ Memory Cells
    Hildegund Ertl; Fiscal Year: 2003
    ..The role of the two different memory CD8+ T cell populations in limiting propagation of the vaccinia gag recombinant virus will be tested by adoptive transfer experiments. ..