rabies vaccines

Summary

Summary: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.

Top Publications

  1. ncbi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
  2. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
  3. ncbi Rabies re-examined
    Charles E Rupprecht
    Rabies Section, WHO Collaborating Centre for Reference and Research on Rabies, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 2:327-43. 2002
  4. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
  5. ncbi A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries
    S Cleaveland
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Vaccine 21:1965-73. 2003
  6. pmc A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa
    Edward Wright
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Vaccine 27:7178-86. 2009
  7. pmc Epidemiological investigations of human rabies in China
    Miao Song
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, PR China
    BMC Infect Dis 9:210. 2009
  8. pmc Transmission dynamics and prospects for the elimination of canine rabies
    Katie Hampson
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
    PLoS Biol 7:e53. 2009
  9. ncbi The implications of metapopulation dynamics on the design of vaccination campaigns
    Hawthorne L Beyer
    The Boyd Orr Centre for Population and Ecosystem Health, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    Vaccine 30:1014-22. 2012
  10. ncbi Rabies virus vaccines: is there a need for a pan-lyssavirus vaccine?
    Jennifer S Evans
    Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey, KT15 3NB, United Kingdom
    Vaccine 30:7447-54. 2012

Research Grants

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
  2. Virus Clearance from the Central Nervous System
    Rodney E Willoughby; Fiscal Year: 2013
  3. Preclinical characterization of a multivalent killed Filovirus/Rabies vaccine
    MATTHIAS JOHANNES SCHNELL; Fiscal Year: 2013
  4. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2012
  5. Therapeutic Antibodies for Rabies
    LAWRENCE KAUVAR; Fiscal Year: 2012
  6. Low cost production of rabies virus antigens in rice grain
    Ning Huang; Fiscal Year: 2011
  7. A novel single dose vaccine for pre-and post-exposure prophylaxis of rabies
    MILOSZ ANDRZEJ FABER; Fiscal Year: 2013
  8. Generation of Novel Recombinant Rabies Virus Vaccines
    BERNHARD F DIETZSCHOLD; Fiscal Year: 2010
  9. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
  10. Human Rabies Virus Vaccine Development
    James McGettigan; Fiscal Year: 2009

Detail Information

Publications356 found, 100 shown here

  1. ncbi Rabies exposure in international travelers: do we miss the target?
    Philippe Gautret
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, AP HM, chemin des Bourrelys, 13915 Marseille, Cedex 20, France
    Int J Infect Dis 14:e243-6. 2010
    ..Little data exist about the spatial distribution of the risk for travelers of being injured by a potentially rabid animal...
  2. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
    ..To quantify the public health and economic burden of endemic canine rabies in Africa and Asia...
  3. ncbi Rabies re-examined
    Charles E Rupprecht
    Rabies Section, WHO Collaborating Centre for Reference and Research on Rabies, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet Infect Dis 2:327-43. 2002
    ..Nevertheless, despite much technical progress in the past century, rabies is a disease of neglect and presents a modern public-health conundrum...
  4. ncbi Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices
    Charles E Rupprecht
    National Center for Emerging and Zoonotic Infectious Diseases proposed, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-9. 2010
    ..Prompt rabies PEP combining wound care, infiltration of RIG into and around the wound, and multiple doses of rabies cell-culture vaccine continue to be highly effective in preventing human rabies...
  5. ncbi A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries
    S Cleaveland
    Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Vaccine 21:1965-73. 2003
    Despite the availability of safe and effective rabies vaccines, the incidence of dog rabies has been increasing throughout much of sub-Saharan Africa...
  6. pmc A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa
    Edward Wright
    Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Vaccine 27:7178-86. 2009
    ..These results suggest the proposed pseudotype assay is a suitable option for undertaking lyssavirus serosurveillance in areas most affected by these infections...
  7. pmc Epidemiological investigations of human rabies in China
    Miao Song
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, PR China
    BMC Infect Dis 9:210. 2009
    ..Moreover, the status of rabies infection and vaccination in dogs, and prophylaxis of humans after rabies exposure were analyzed...
  8. pmc Transmission dynamics and prospects for the elimination of canine rabies
    Katie Hampson
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
    PLoS Biol 7:e53. 2009
    ..Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal...
  9. ncbi The implications of metapopulation dynamics on the design of vaccination campaigns
    Hawthorne L Beyer
    The Boyd Orr Centre for Population and Ecosystem Health, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    Vaccine 30:1014-22. 2012
    ....
  10. ncbi Rabies virus vaccines: is there a need for a pan-lyssavirus vaccine?
    Jennifer S Evans
    Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey, KT15 3NB, United Kingdom
    Vaccine 30:7447-54. 2012
    ..Critically, from both a human and animal health perspective, current rabies vaccines appear able to protect against lyssaviruses classified within phylogroup I...
  11. pmc Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Vaccine 26:6405-14. 2008
    ....
  12. ncbi First administration to humans of a monoclonal antibody cocktail against rabies virus: safety, tolerability, and neutralizing activity
    A B H Bakker
    Crucell Holland BV, Leiden, The Netherlands
    Vaccine 26:5922-7. 2008
    ..All subjects had adequate (>0.5IU/mL) RVNA levels from day 14 onwards when combined with rabies vaccine. CL184 appears promising as an alternative to RIG in PEP...
  13. ncbi Use of neutralizing murine monoclonal antibodies to rabies glycoprotein in passive immunotherapy against rabies
    Kader Muhamuda
    Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Hum Vaccin 3:192-5. 2007
    ..These Mabs were found to be 2,000 times more potent than commercial ERIG in terms of effective protein concentration and neutralizing titer. Further studies are required to study their utility in humans exposed to rabies...
  14. ncbi Animal bites and rabies exposure in Australian travellers
    Deborah J Mills
    Dr Deb The Travel Doctor, Brisbane, QLD
    Med J Aust 195:673-5. 2011
    ..To examine the circumstances of animal exposure in a case series of Australian travellers who required rabies postexposure prophylaxis, and to assess the appropriateness of current guidelines for rabies pre-exposure vaccination...
  15. pmc Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses
    Joseph E Blaney
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:10605-16. 2011
    ....
  16. ncbi Rabies in Estonia: situation before and after the first campaigns of oral vaccination of wildlife with SAG2 vaccine bait
    Enel Niin
    Veterinary and Food Board of Estonia VFB, Väike Paala Street 3, 11415 Tallinn, Estonia, France
    Vaccine 26:3556-65. 2008
    ..5%) occurred within the vaccinated area. Only 17 cases were diagnosed between 1 June and 31 December 2006. In 2007, by the end of May, only two rabies cases have been registered...
  17. ncbi Stray dog population demographics in Jodhpur, India following a population control/rabies vaccination program
    Sarah C Totton
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Prev Vet Med 97:51-7. 2010
    ..A surgical sterilization coverage under 40% would maintain the dog population at current levels...
  18. pmc Imported episodic rabies increases patient demand for and physician delivery of antirabies prophylaxis
    Zélie Lardon
    INSERM, U657 and Institut Pasteur, PhEMI, Paris, France
    PLoS Negl Trop Dis 4:e723. 2010
    ....
  19. ncbi Current status of human rabies transmitted by dogs in Latin America
    Maria Cristina Schneider
    Veterinary Public Health Unit, Pan American Health Organization, Washington, DC 20037 2895, USA
    Cad Saude Publica 23:2049-63. 2007
    ..Samples sent for rabies testing represent 0.05% of the estimated canine population (range: 0.001 to 0.2%). The countries are quite close to achieving the goal...
  20. pmc Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus
    Milosz Faber
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 106:11300-5. 2009
    ....
  21. pmc Rabies control in rural Africa: evaluating strategies for effective domestic dog vaccination
    M Kaare
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vaccine 27:152-60. 2009
    ..These results suggest that rabies control is logistically feasible across most of the developing world and that the annual costs of effective vaccination campaigns in Tanzania are likely to be affordable...
  22. ncbi Efficacy of rabies biologics against new lyssaviruses from Eurasia
    Cathleen A Hanlon
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road NE, Rabies Team, Atlanta, GA 30333, USA
    Virus Res 111:44-54. 2005
    ..The potential impact of these new lyssaviruses on human and domestic animal health and the impact on the putative bat reservoir populations will require further field and laboratory investigation...
  23. ncbi The immune response to rabies virus infection and vaccination
    Nicholas Johnson
    Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
    Vaccine 28:3896-901. 2010
    ..This could help identify ways in which the response to prophylactic vaccination can be enhanced and how the natural immune response to infection can be boosted to combat neuroinvasion...
  24. ncbi Comparison of an anti-rabies human monoclonal antibody combination with human polyclonal anti-rabies immune globulin
    Jaap Goudsmit
    Crucell Holland BV, Leiden, The Netherlands
    J Infect Dis 193:796-801. 2006
    ..These results demonstrate that the human MAb cocktail of CR57 and CR4098 is a safe and efficacious alternative to RIG in rabies postexposure prophylaxis...
  25. pmc Rabies trend in China (1990-2007) and post-exposure prophylaxis in the Guangdong province
    Han Si
    1Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, PR China
    BMC Infect Dis 8:113. 2008
    ....
  26. pmc Transmission dynamics and economics of rabies control in dogs and humans in an African city
    J Zinsstag
    Swiss Tropical Institute, PO Box, CH 4002 Basle, Switzerland
    Proc Natl Acad Sci U S A 106:14996-5001. 2009
    ..Beyond a time-frame of 7 years, it appears to be more cost-effective to combine parenteral dog-vaccination campaigns with human PEP compared to human PEP alone...
  27. pmc Tactics and economics of wildlife oral rabies vaccination, Canada and the United States
    Ray T Sterner
    US Department of Agriculture, Fort Collins, Colorado 80521 2154, USA
    Emerg Infect Dis 15:1176-84. 2009
    ..Modeling studies, involving diverse assumptions, have shown that ORV programs can be cost-efficient and yield benefit:cost ratios >1.0...
  28. pmc The feasibility of canine rabies elimination in Africa: dispelling doubts with data
    Tiziana Lembo
    Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 4:e626. 2010
    ..Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent...
  29. pmc European bat lyssaviruses: an emerging zoonosis
    A R Fooks
    Rabies Research and Diagnostic Group, Veterinary Laboratories Agency Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, New Haw, Addlestone, Surrey KT15 3NB, UK
    Epidemiol Infect 131:1029-39. 2003
    ..This review provides a brief history of EBLVs, their distribution in host species and the public health risks...
  30. pmc Reemergence of rabies in Chhukha district, Bhutan, 2008
    - Tenzin
    The University of Sydney, Camden, New South Wales, Australia
    Emerg Infect Dis 16:1925-30. 2010
    ..The outbreak was controlled by culling free-roaming dogs. To prevent spread into the interior of Bhutan, a well-coordinated national rabies control program should be implemented in disease-endemic areas...
  31. ncbi Impact of plasmid supercoiling on the efficacy of a rabies DNA vaccine to protect cats
    Lionel Cupillard
    MERIAL S A S, Analytical Biodevelopment, 254 rue Marcel Merieux, 69007 Lyon, France
    Vaccine 23:1910-6. 2005
    ..Therefore, it is proposed that the target threshold of supercoiling that must be met by a rabies DNA vaccine to guarantee optimal immune responses and protection, be set at 70% of supercoiled molecules in the vaccine solution...
  32. ncbi The rabies situation in Western Europe
    A I Wandeler
    Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, Ottawa, Ontario, Canada
    Dev Biol (Basel) 131:19-25. 2008
    ..Reporting of human post-exposure prophylaxis is inconsistent due the lack of information. Similarly, data on domestic animal rabies prophylaxis seem to be difficult to collect...
  33. ncbi Development of a bait and baiting system for delivery of oral rabies vaccine to free-ranging African wild dogs (Lycaon pictus)
    D L Knobel
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa
    J Wildl Dis 38:352-62. 2002
    ..During 46 hr of diurnal observations of free-ranging wild dogs only two baits were lost to non-target species. A baiting system for the oral vaccination of captive and free-ranging wild dogs is proposed...
  34. ncbi Rabies remains a 'neglected disease'
    A R Fooks
    Euro Surveill 10:1-2. 2005
  35. ncbi Rabies DNA vaccination of non-human primates: post-exposure studies using gene gun methodology that accelerates induction of neutralizing antibody and enhances neutralizing antibody titers
    Donald L Lodmell
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    Vaccine 20:2221-8. 2002
    ..These data will be useful for the refinement, development, and implementation of future pre- and post-exposure rabies DNA vaccination studies...
  36. pmc Oral vaccination of mice with adenoviral vectors is not impaired by preexisting immunity to the vaccine carrier
    Z Q Xiang
    The Wistar Institute Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:10780-9. 2003
    ..Oral priming-boosting regimens with either heterologous or homologous adenoviral vectors used sequentially increased both mucosal and systemic antibody titers to rabies virus [corrected]..
  37. ncbi [Rabies-free status of Switzerland following 30 years of rabies in foxes]
    R G Zanoni
    Institut für Veterinär Virologie und Pathologisches Institut, Universitat Bern
    Schweiz Arch Tierheilkd 142:423-9. 2000
    ..To eliminate rabies, a total of 2.8 million baits containing a modified live virus were distributed--mostly by hand--in the field...
  38. ncbi Current rabies vaccines and prophylaxis schedules: preventing rabies before and after exposure
    M J Warrell
    Oxford Vaccine Group, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Rd, Headington, Oxford OX3 7LJ, UK
    Travel Med Infect Dis 10:1-15. 2012
    ..Provision of economical rabies prophylaxis can be improved. Decisions to change recommendations should take account of the immunological, financial, practical and logistical aspects of dog bite treatment in remote areas...
  39. pmc Eliminating rabies in Estonia
    Florence Cliquet
    Nancy OIE WHO EU Laboratory for Rabies and Wildlife, French Agency for Food, Environmental and Occupational Health and Safety, Malzeville, France
    PLoS Negl Trop Dis 6:e1535. 2012
    ..An analysis of the number of baits distributed and the funding allocated by the European Commission showed that the strategy for rabies control is more cost-effective in Estonia than in Latvia and Lithuania...
  40. pmc Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 200:1251-60. 2009
    ..The data presented in this article suggest that the M gene-deleted RV vaccine is safe and effective and holds the potential of replacing current pre- and postexposure RV vaccines...
  41. pmc Protective vaccine-induced CD4(+) T cell-independent B cell responses against rabies infection
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Virol 86:11533-40. 2012
    ..We show that vaccines that can exploit early pathways of B cell activation and development may hold the key for the development of a single-dose RV vaccine wherein the rapid induction of VNA is critical...
  42. ncbi DNA immunization protects nonhuman primates against rabies virus
    D L Lodmell
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Nat Med 4:949-52. 1998
    ..Our findings indicate that DNA vaccines may have a promising future in human rabies immunization...
  43. ncbi Antibodies induced by vaccination with purified chick embryo cell culture vaccine (PCECV) cross-neutralize non-classical bat lyssavirus strains
    Claudius Malerczyk
    Novartis Vaccines and Diagnostics, Marburg, Germany
    Vaccine 27:5320-5. 2009
    ..50). In conclusion, vaccination with PCECV produces adequate VNA concentrations against classical RABV as well as non-classical lyssavirus strains ABLV, EBLV-1, and EBLV-2...
  44. ncbi Field trials of a very potent rabies DNA vaccine which induced long lasting virus neutralizing antibodies and protection in dogs in experimental conditions
    Chokri Bahloul
    Laboratoire d Immunopathologie Vaccinologie et Génétique Moléculaire, Institut Pasteur de Tunis, 13 Place Pasteur BP 74, 1002 Tunis Belvedere, Tunisia
    Vaccine 24:1063-72. 2006
    ..Four years after vaccine administration of either DNA or cell culture-derived rabies vaccines, full protection against a rabies peripheral challenge was achieved...
  45. ncbi Geographical information systems in the management of the 2009-2010 emergency oral anti-rabies vaccination of foxes in north-eastern Italy
    Paolo Mulatti
    Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell Universita 10, Legnaro, Padua, Italy
    Geospat Health 5:217-26. 2011
    ..In addition, it facilitated the identification of areas with suboptimal bait density that would require additional flights or supplementary, manual distribution...
  46. pmc Molecular characterization of China rabies virus vaccine strain
    Wenqiang Jiao
    State Key Laboratory of Veterinary Etiological Biology, Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Xujia ping 1, Yanchang bu, Lanzhou, Gansu, China
    Virol J 8:521. 2011
    ..The main goal of the present study is to amplify the whole genome of aG strain, and genetic relationships between other vaccine strains and wild strains were analyzed...
  47. ncbi Rabies surveillance in the United States during 2011
    Jesse D Blanton
    Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Disease, CDC, Atlanta, GA 30333, USA
    J Am Vet Med Assoc 241:712-22. 2012
    ..Three cases reported from Massachusetts, New Jersey, and New York were determined to be a result of canine rabies virus variants acquired outside the United States...
  48. pmc Characterization of a single-cycle rabies virus-based vaccine vector
    Emily A Gomme
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Virol 84:2820-31. 2010
    ..These findings demonstrate that single-cycle RV is an effective alternative to replication-competent RV vectors for future development of vaccines for HIV-1 and other infectious diseases...
  49. pmc Experimental rabies vaccines for humans
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Vaccine Center, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, JAH 466, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 9:1177-86. 2010
    ..The usefulness of human rabies vaccines is hampered by high cost, complicated vaccination regimens and lack of compliance, especially in areas of ..
  50. ncbi Immune response after rabies vaccine in a kidney transplant recipient
    R Rodríguez-Romo
    Transplantation Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Transpl Infect Dis 13:492-5. 2011
    ..Nevertheless, such an outcome would have been possible only with the combined management strategy implemented...
  51. ncbi Evidence for a 4-dose vaccine schedule for human rabies post-exposure prophylaxis in previously non-vaccinated individuals
    Charles E Rupprecht
    National Center for Zoonotic, Vector Borne and Enteric Diseases, 1600 Clifton Road N E, Atlanta, GA 30333, USA
    Vaccine 27:7141-8. 2009
    ....
  52. ncbi Efficacy of an oral vaccinia-rabies glycoprotein recombinant vaccine in controlling epidemic raccoon rabies in New Jersey
    D E Roscoe
    New Jersey Division of Fish, Game and Wildlife, Trenton 08625 0400, USA
    J Wildl Dis 34:752-63. 1998
    ....
  53. ncbi Failure of pre- and postexposure rabies vaccinations in a child infected with HIV
    C Pancharoen
    Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Scand J Infect Dis 33:390-1. 2001
    ..Sequentially monitored rabies neutralizing antibody titers were below the WHO minimum acceptable level (> 0.15 IU/ml) in all specimens. Rabies prevention in HIV-infected persons with severe immune suppression requires further study...
  54. ncbi Epidemiology of animal bites and rabies cases in India. A multicentric study
    R L Ichhpujani
    WHO Collaborating Centre for Rabies Epidemiology, National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi
    J Commun Dis 40:27-36. 2008
    ..There is a need to create awareness regarding epidemiology and at-home and hospital management of animal bites among the service providers and general community...
  55. ncbi Overview, prevention, and treatment of rabies
    Andrea Julia Nigg
    Department of Pharmacy Services, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    Pharmacotherapy 29:1182-95. 2009
    ..The recently developed Milwaukee Protocol added induction of therapeutic coma to supportive care measures and antivirals; however, its use has shown inconsistent outcomes...
  56. pmc Rabies virus glycoprotein as a carrier for anthrax protective antigen
    Mary Ellen Smith
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 353:344-56. 2006
    ..These data demonstrate that a viral envelope protein can carry a bacterial protein and that a viral carrier can display whole polypeptides compared to the limited epitope presentation of previous viral systems...
  57. ncbi Safety and efficacy of the oral rabies vaccine SAG2 in raccoon dogs
    F Cliquet
    AFSSA Nancy, WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Community Reference Laboratory for Rabies Serology, Domaine de Pixerecourt, Malzeville, France
    Vaccine 24:4386-92. 2006
    ..All 28 vaccinated animals developed high rabies neutralizing antibody titres. After virulent challenge, all 11 controls succumbed to rabies, whereas all 28 vaccinates survived...
  58. ncbi Knowledge, attitudes, and practices of French travelers from Marseille regarding rabies risk and prevention
    Matthias Altmann
    Service des Maladies Infectieuses et Tropicales, Hopital Nord, Marseille, France
    J Travel Med 16:107-11. 2009
    ..To assess the awareness of the mode of rabies transmission, travel-associated rabies risk, and adequate preventive measures among French travelers...
  59. ncbi Human exposure to potential rabies virus transmitters in Olinda, State of Pernambuco, between 2002 and 2006
    Filipe Dantas-Torres
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Soc Bras Med Trop 40:617-21. 2007
    ....
  60. ncbi Rabies update for travel medicine advisors
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Clin Infect Dis 37:96-100. 2003
    ..Safe and effective tissue-culture rabies vaccines and human and equine rabies immunoglobulins (HRIG and ERIG) are not readily available in many regions where ..
  61. ncbi Control of rabies in Jaipur, India, by the sterilisation and vaccination of neighbourhood dogs
    J F Reece
    Help in Suffering, Maharani Farm, Durgapura, Jaipur 302018, Rajasthan, India
    Vet Rec 159:379-83. 2006
    ..The records of human cases of rabies seen in the main government hospital of the city between January 1992 and December 2002 showed that the number of cases had declined to zero in the programme area but increased in other areas...
  62. pmc Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
    ..This robust microassay will improve our understanding of the protective humoral immunity that current rabies vaccines confer against emerging lyssaviruses, and will be applicable to surveillance studies, thus helping to control ..
  63. ncbi Can rabies be eradicated?
    C E Rupprecht
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dev Biol (Basel) 131:95-121. 2008
    ....
  64. ncbi Cryptogenic rabies, bats, and the question of aerosol transmission
    Robert V Gibbons
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Ann Emerg Med 39:528-36. 2002
    ..The known pathogenesis of rabies and available data suggest that all or nearly all cases of human rabies attributable to bats were transmitted by bat bites that were minimized or unrecognized by the patients...
  65. ncbi Elimination of rabies from red foxes in eastern Ontario
    C D MacInnes
    Rabies Unit, Ontario Ministry of Natural Resources, Peterborough, Canada
    J Wildl Dis 37:119-32. 2001
    ..Persistence of terrestrial rabies, and ease of elimination, appeared to vary geographically, and probably over time. Ecological factors which enhance or reduce the long term survival of rabies in wild foxes are poorly understood...
  66. ncbi Clinical practice. Prophylaxis against rabies
    Charles E Rupprecht
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 351:2626-35. 2004
  67. ncbi Genetic characterisation of attenuated SAD rabies virus strains used for oral vaccination of wildlife
    Lutz Geue
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
    Vaccine 26:3227-35. 2008
    ..Our data also supports the idea of a possible recombination that had occurred during the derivation of the European branch of SAD viruses. If confirmed, this recombination event would be the first one reported among RABV vaccine strains...
  68. pmc Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
    Kalifa Bojang
    Medical Research Council Laboratories, Banjul, The Gambia
    Hum Vaccin 5:242-7. 2009
    ..This study provides the first indication of the long-term safety and persistence of anti-CS and anti-HBs antibodies of the RTS,S vaccine candidate in combination with the novel AS02 Adjuvant System...
  69. ncbi Rabies epidemiology and control in Turkey: past and present
    N Johnson
    Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for Characterisation of Rabies and Rabies related Viruses, Veterinary Laboratories Agency Weybridge, Surrey, UK
    Epidemiol Infect 138:305-12. 2010
    ..This review considers the current state of rabies in Turkey including current control measures, the varying epidemiology of the disease throughout this country and the prospects for rabies elimination...
  70. ncbi Failure of rabies postexposure prophylaxis in patients presenting with unusual manifestations
    Prapimporn Shantavasinkul
    Queen Saovabha Memorial Institute, The Thai Red Cross Society World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention, Bangkok, Thailand
    Clin Infect Dis 50:77-9. 2010
    ..Atypical presentations and history of rabies postexposure prophylaxis led to delayed diagnosis. Nucleocapsid and glycoprotein genes of rabies viruses from the patient's and biting dog's brains were of identical sequences...
  71. ncbi Comparison of antibody responses after vaccination with two inactivated rabies vaccines
    J M Minke
    Merial SAS, 254, rue Marcel Merieux, 69007 Lyon, France
    Vet Microbiol 133:283-6. 2009
    ..and subcutaneously vaccinated with a single dose of one of two commercially available monovalent inactivated rabies vaccines: RABISIN (Merial, France) (group A) and NOBIVAC Rabies (Intervet International) (group B)...
  72. ncbi Factors influencing the antibody response of dogs vaccinated against rabies
    Lorna J Kennedy
    Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Vaccine 25:8500-7. 2007
    ....
  73. ncbi A quantitative indirect ELISA to monitor the effectiveness of rabies vaccination in domestic and wild carnivores
    A Servat
    AFSSA Nancy, Laboratoire d Etudes et de Recherches sur la Rage et la Pathologie des Animaux Sauvages, Domaine de Pixerecourt, B P 9 54220 Malzéville, France
    J Immunol Methods 318:1-10. 2007
    ....
  74. ncbi Characterization of Russian rabies virus vaccine strain RV-97
    A Metlin
    Department of Animal Diseases and Food Safety Research, Virology, Mustialankatu 3, FI 00790 Helsinki, Finland
    Virus Res 132:242-7. 2008
    ..It also contains several unique amino acid changes in known immunodominant sites of G and P proteins...
  75. ncbi An evaluation of two commercially available ELISAs and one in-house reference laboratory ELISA for the determination of human anti-rabies virus antibodies
    Ryan J Welch
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    J Med Microbiol 58:806-10. 2009
    ..The results of this study offer insight into the availability of alternative, less-complex methods to monitor rabies antibody titres in at-risk individuals following vaccination...
  76. ncbi Benefit cost scenarios of potential oral rabies vaccination for skunks in California
    Stephanie A Shwiff
    National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, US Department of Agriculture, Fort Collins, Colorado 80521 2154, USA
    J Wildl Dis 45:227-33. 2009
    ..16 and 2.91 and between 0.34 and 6.35 for Scenarios 1 and 2, respectively. Economic issues relevant to potentially managing skunk-variant rabies with ORV are discussed...
  77. ncbi Cost comparison of rabies pre-exposure vaccination with post-exposure treatment in Thai children
    Pannipa Chulasugandha
    Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand
    Vaccine 24:1478-82. 2006
    ..It was found that costs of both strategies, PREP of children or PEP of exposed, become equal when the dog bite incidence is 2-30%; depending on which post-exposure treatment regimens (PEP) are used...
  78. ncbi The challenge to provide affordable rabies post-exposure treatment
    Mary J Warrell
    Centre for Tropical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Vaccine 21:706-9. 2003
    Treatment with Semple or suckling mouse brain rabies vaccines persists in many countries of Asia, Africa and South America...
  79. ncbi Effect of maternal immunity on the immune response to oral vaccination against rabies in young foxes
    T F Müller
    Institute for Epidemiological Diagnostics, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
    Am J Vet Res 62:1154-8. 2001
    ..To determine effect of maternal antibodies on immune response to oral vaccination against rabies in young foxes...
  80. ncbi The control of raccoon rabies in Ontario Canada: proactive and reactive tactics, 1994-2007
    R C Rosatte
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, Peterborough, Ontario, Canada
    J Wildl Dis 45:772-84. 2009
    ..The last case occurred on 23 September 2005 with Ontario being free of reported raccoon rabies to 10 November 2008, proving that TVR and PIC are effective tactics for the control of this disease...
  81. ncbi Fatal rabies despite post-exposure prophylaxis
    D G Deshmukh
    Department of Microbiology, Government Medical College, Panchakki Road, Aurangabad 431 001, Maharashtra, India
    Indian J Med Microbiol 29:178-80. 2011
    ....
  82. ncbi Identification of a conserved linear epitope at the N terminus of the rabies virus glycoprotein
    K L Mansfield
    Rabies Research and Diagnostic Group WHO Collaborating Centre, Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Surrey, KT15 3NB, UK
    J Gen Virol 85:3279-83. 2004
    ..In a multimeric form, the peptide could induce an epitope-specific response following immunization in rabbits and mice...
  83. pmc Oral rabies vaccination in north america: opportunities, complexities, and challenges
    Dennis Slate
    USDA APHIS Wildlife Services, National Rabies Management Program, Concord, New Hampshire, USA
    PLoS Negl Trop Dis 3:e549. 2009
    ..Progress continues toward the development and testing of new bait-vaccine combinations that increase the chance for improved delivery and performance in the diverse meso-carnivore rabies reservoir complex in the US...
  84. ncbi Nonclinical toxicology study of recombinant-plasmid DNA anti-rabies vaccines
    P Uday Kumar
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, Andhra Pradesh 500007, India
    Vaccine 24:2790-8. 2006
    ..There were no observational adverse effects even at levels of 10x therapeutic dose administration of DRV and CRV. The procedure also emphasizes on the designing of protocols for the products developed by recombinant technique...
  85. ncbi Immunogenicity, safety and lot consistency in adults of a chromatographically purified Vero-cell rabies vaccine: a randomized, double-blind trial with human diploid cell rabies vaccine
    R L Jones
    Department of Microbiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1677, USA
    Vaccine 19:4635-43. 2001
    ..The results of these studies indicate that CPRV administered intramuscularly to healthy adults is immunogenic and is associated with fewer local and systemic reactions than HDCV...
  86. ncbi Post-exposure therapy in mice against experimental rabies: a single injection of DNA vaccine is as effective as five injections of cell culture-derived vaccine
    Chokri Bahloul
    Laboratory of Immunology, Vaccinology and Molecular Genetics, Institut Pasteur de Tunis, 13 Place Pasteur BP 74, 1002, Tunis Belvedere, Tunisia
    Vaccine 22:177-84. 2003
    ..We conclude that rabies post-exposure vaccination in BALB/c mice, based on a single administration of rabies DNA vaccine might be at least as effective as five injections of cell culture-derived vaccine...
  87. ncbi Immunogenicity and efficacy of two rabies vaccines in wild-caught, captive raccoons
    L J Brown
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, 2140 East Bank Drive, Peterborough, Ontario K9J 7B8, Canada
    J Wildl Dis 47:182-94. 2011
    The immunogenicity and efficacy of two rabies vaccines in wild-caught, captive raccoons (Procyon lotor) were investigated...
  88. ncbi [Immune response produced by anti-rabies vaccines in marmosets (Callithrix sp)]
    M C Andrade
    Laboratorio de Biologia Animal, Empresa de Pesquisa Agropecuária do Estado do Rio de Janeiro, Niteroi, RJ, Brasil
    Rev Soc Bras Med Trop 32:533-40. 1999
    In order to evaluate the immune response produced by rabies vaccines in new world nonhuman primates, thirty marmosets (Callithrix sp) were divided into five groups of six individuals and submitted to five different antirabies vaccination ..
  89. ncbi Optimal control of vaccine distribution in a rabies metapopulation model
    Erika Asano
    Environmental Science, Policy and Geography Univesity of South Florida, St Petersburg, FL 33701, USA
    Math Biosci Eng 5:219-38. 2008
    ..This strategy is chosen to limit the disease optimally by making the number of infections as small as possible while accounting for the cost of vaccination...
  90. ncbi Intra-dermal administration of rabies vaccines in developing countries: at an affordable cost
    RAMESH VERMA
    Department of Community Medicine, Pt B D Sharma PGIMS, Rohtak, Haryana, India
    Hum Vaccin 7:792-4. 2011
    ..The ID route is ideal in terms of economic benefits, safety and efficacy. This reduces the cost of vaccination by about 68%, which is clearly an attractive option for resource-starved countries like India...
  91. ncbi Characterization of P gene-deficient rabies virus: propagation, pathogenicity and antigenicity
    Kinjiro Morimoto
    Department of Virology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Virus Res 111:61-7. 2005
    ..The def-P virus would be a potential resource of safe live-attenuated rabies vaccine...
  92. ncbi Low-coverage vaccination strategies for the conservation of endangered species
    D T Haydon
    Division of Environmental and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Nature 443:692-5. 2006
    ....
  93. pmc Risk for rabies importation from North Africa
    Philippe Gautret
    Hopital Nord, Marseille, France
    Emerg Infect Dis 17:2187-93. 2011
    ..Rabies surveillance and control should therefore be reinforced in North Africa, and travelers to North Africa should receive appropriate information about rabies risk and prevention...
  94. ncbi Attaining raccoon rabies management goals: history and challenges
    D Slate
    United States Department of Agriculture, Animal and Plant Heath Inspection Service, Wildlife Services, Concord, NH 03301, USA
    Dev Biol (Basel) 131:439-47. 2008
    ..We report on the challenges of achieving enhanced rabies surveillance, containment of raccoon rabies, and local elimination of raccoon rabies, as well as the need for international coordination in meeting these challenges...
  95. pmc A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence
    Amy B Papaneri
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA
    Virology 434:18-26. 2012
    ..In summary, our findings indicate that RV-GP retains the attenuation phenotype of the live-attenuated RABV vaccine, and RVΔG-GP would appear to be an even safer alternative for use in wildlife or consideration for human use...
  96. ncbi Field evaluation of an inactivated vaccine to control raccoon rabies in Ontario, Canada
    K G Sobey
    Ontario Ministry of Natural Resources, Wildlife Research and Development Section, Trent University, DNA Building, 2140 East Bank Dr, Peterborough, Ontario K9J 7B8, Canada
    J Wildl Dis 46:818-31. 2010
    ..A strong anamnestic response was detected after booster vaccinations. IMRAB3 by IM injection was found to be an efficacious vaccine for rabies control in raccoons...
  97. ncbi Rabies post-exposure prophylaxis in travellers returning from Bali, Indonesia, November 2008 to March 2010
    P Gautret
    Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, France
    Clin Microbiol Infect 17:445-7. 2011
    ..The data demonstrate that the majority of animal-related injuries in travellers returning from Bali are associated with exposure to monkeys, and not dog bites/scratches. The clinical implications of this are discussed...
  98. pmc Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation
    Lihong Tao
    Veterinary Public Health Laboratory of Ministry of Agriculture, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
    J Virol 84:8926-36. 2010
    ..These results indicate that attenuation of the RV Flury strain results from the coevolution of G and L elements and provide important information for the generation of safer and more effective modified live rabies vaccine...
  99. ncbi Characterization of recombinant rabies virus carrying double glycoprotein genes
    Junji Hosokawa-Muto
    The United Graduate School of Veterinary Sciences, Faculty of Applied Biological Sciences, Gifu University, Gifu 501 1193, Japan
    Microbiol Immunol 50:187-96. 2006
    ..The results suggest that the R(NPMGGL) strain carrying double G genes might be a useful candidate for development of a new inactivated rabies vaccine...
  100. ncbi [Human rabies in France in 2004: update and management]
    H Peigue-Lafeuille
    Service de Virologie, Faculte de Medecine, 28, Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    Med Mal Infect 34:551-60. 2004
    ..People traveling abroad, particularly to Africa, are warned not to approach unknown animals (especially dogs) nor to try to import them, and are advised to comply with vaccinal recommendations for travelers, particularly for toddlers...
  101. ncbi [The first case of rabies in Sweden in 26 years. Inform travellers abroad about risks and treatment following suspected infection]
    J Hojer
    Infektionskliniken, Södersjukhuset Huddinge Universitetssjukhus
    Lakartidningen 98:1216-20. 2001
    ..Tourists must be informed of the vital importance of post-exposure prophylaxis after suspected infection...

Research Grants39

  1. MOLECULAR PATHOGENESIS OF RABIES
    Bernhard Dietzschold; Fiscal Year: 2006
    ..from these studies will have practical implications for the development of safer and more efficacious live rabies vaccines, and will provide further basic information on rabies virus pathogenicity...
  2. Virus Clearance from the Central Nervous System
    Rodney E Willoughby; Fiscal Year: 2013
    ....
  3. Preclinical characterization of a multivalent killed Filovirus/Rabies vaccine
    MATTHIAS JOHANNES SCHNELL; Fiscal Year: 2013
    ..Of note, te further characterization of this vaccine platform will establish the necessary parameters not only for a filovirus vaccine but also the use of this platform for other emerging and reemerging infectious diseases. ..
  4. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2012
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. The experiments in this proposal are designed to test the hypothesis that replication-deficient RVs would ..
  5. Therapeutic Antibodies for Rabies
    LAWRENCE KAUVAR; Fiscal Year: 2012
    ..The G protein is the same antigen used in rabies vaccines and has been shown to elicit protective antibodies...
  6. Low cost production of rabies virus antigens in rice grain
    Ning Huang; Fiscal Year: 2011
    ..The vaccine, upon meeting all production, quality, and regulatory requirements, would be used in baits for state and federal rabies prevention programs. ..
  7. A novel single dose vaccine for pre-and post-exposure prophylaxis of rabies
    MILOSZ ANDRZEJ FABER; Fiscal Year: 2013
    ..The availability of an affordable rabies vaccine that can induce log-lasting immunity after a single immunization could make global eradication of human rabies feasible. ..
  8. Generation of Novel Recombinant Rabies Virus Vaccines
    BERNHARD F DIETZSCHOLD; Fiscal Year: 2010
    We propose to use safe live-attenuated recombinant rabies vaccines to specifically target the induction of long-lasting immunity after administration of a single vaccine dose and extend the utility of the vaccines into the period when ..
  9. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  10. Human Rabies Virus Vaccine Development
    James McGettigan; Fiscal Year: 2009
    ..of passive immunization [(rabies immune globulin (RIG)] along with five active immunizations with inactivated rabies vaccines. The experiments in this proposal are designed to test the hypothesis that a matrix (M) gene-deleted RV ..
  11. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2003
    ..II objectives of this research project are to extend safety and efficacy testing of these newly developed rabies vaccines in laboratory rodents and target animals (raccoon and skunk), and to choose a strain for which a master seed ..
  12. POTENT RABIES VACCINES FOR FREE RANGING CARNIVORES
    KOON PAK; Fiscal Year: 2000
    ..Unfortunately, the currently available oral rabies vaccines induce insufficient immunity in dogs or skunks...
  13. NOVEL METHODS FOR TREATMENT AND POSTEXPOSURE PROPHYLAXIS
    Thomas Monath; Fiscal Year: 1993
    ..The toxicology and efficacy studies will provide detailed information on the usefulness of the B9 anti-id for treatment and prophylaxis of human rabies...
  14. NONINVASIVE DELIVERY OF SKIN-TARGETED RABIES VACCINES
    DE CHU TANG; Fiscal Year: 2001
    ..Adapted from Applicant's Abstract) Our aim is to develop a simple and effective method for the delivery of rabies vaccines by topical application of adenovirus-based expression vectors using a skin patch in a noninvasive mode...
  15. Formulation of Ambient Temperature and Humidity Stable Rabies Vaccines for Oral D
    VICTOR BRONSHTEIN; Fiscal Year: 2008
    ..Currently, about 15 states distribute edible rabies vaccines for wild animals in an attempt to eradicate the disease...
  16. Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    DOUGLAS HOOPER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..abstract_text> ..
  18. Passive Immunization for Neurotropic Virus Infection
    DOUGLAS HOOPER; Fiscal Year: 2009
    ..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
  19. Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?
    DOUGLAS HOOPER; Fiscal Year: 2007
    ..In this proposal we will use a model system to determine whether raising uric acid levels may provide a safe, natural means of preventing secondary nerve cell death and improving the outcome of spinal cord injury. ..
  20. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
    ..of one dose of passive immunization (rabies immune globulin) along with five active immunizations with rabies vaccines. We hypothesize that replication-deficient RVs will make excellent rabies PEPs...
  21. Developing Avirulent Rabies Virus Vaccines
    Zhen F Fu; Fiscal Year: 2010
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  22. Prime/Boost Immunization against HIV-1 by Viral Vectors
    Matthias Schnell; Fiscal Year: 2003
    ....
  23. CANCER VACCINE TO P53
    Hildegund Ertl; Fiscal Year: 2001
    ....
  24. Killed Rhabdoviruses as Novel Anthrax Vaccines
    Matthias Schnell; Fiscal Year: 2006
    ..Lastly, Anthrax challenge experiments of the most promising constructs in mice will indicate if the inducted responses are protective against Anthrax infection. ..
  25. RABIES VIRUS-BASED VECTORS AS AN HIV-1 VACCINE
    Matthias Schnell; Fiscal Year: 2008
    ..Thus, we will pursue several complementary approaches designed to further improve our HIV-1 vaccines, study their anti-HIV directed immunogenicity in detail, and test their efficacy in the rhesus macaque model system. ..
  26. Astrocytes and Restricted HIV-1 Replication
    Matthias Schnell; Fiscal Year: 2007
    ..Thus, these complementary approaches will be utilized to analyze, on molecular levels, the mechanisms of HIV-1 reservoirs and persistence in human astrocytes. [unreadable] [unreadable]..
  27. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..abstract_text> ..
  28. A novel rhabdovirus-based anthrax vaccine
    Matthias Schnell; Fiscal Year: 2007
    ..The general concept, if proven successful, may also lead to a general technique for developing more effective vaccines for other important pathogens. [unreadable] [unreadable] [unreadable]..
  29. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 3, we are proposing experiments in non-human primates to test the vaccine for efficacy in pre- and post-challenge vaccination experiments with and without concomitant application of RIG. [unreadable] [unreadable]..
  30. Oral Vaccine to Inhalation Rabies
    Hildegund Ertl; Fiscal Year: 2006
    ..In aim 2, the AdC68rab.gp vaccine will be tested in a non-human primate rabies virus challenge model. ..
  31. Prime-boost regimens for adenoviral vaccines to HIV-1
    Hildegund Ertl; Fiscal Year: 2004
    ..abstract_text> ..
  32. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  33. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  34. E1-deleted adenoviral vectors for oral immunization
    Hildegund Ertl; Fiscal Year: 2004
    ..In aim 4, we will determine the tropism of the simian and human Ad recombinants upon oral application emphasizing localization of and cytokine production by transduced antigen presenting cells (APCs). ..
  35. Mucosal Vaccine to HIV-1 Gag
    Hildegund Ertl; Fiscal Year: 2002
    ..In the third aim, we will test a prime-boost regimen using DNA vaccines, expressing Gag for systemic priming combined with the adenoviral recombinants for systemic or intranasal booster immunization. ..
  36. CANCER VACCINES TO HPV-16 ASSOCIATED TUMOR
    Hildegund Ertl; Fiscal Year: 2001
    ..In case the applicant's hypothesis is correct, data gathered within the realm of this application will serve as the basis for a clinical Phase I trial. ..
  37. TRAINING PROGRAM IN THE IMMUNOBIOLOGY OF VACCINES
    Hildegund Ertl; Fiscal Year: 2007
    ..All of the course work will take place at The Wistar Institute. ..
  38. HIV-1 Vaccine-Induced CD8+ Memory Cells
    Hildegund Ertl; Fiscal Year: 2003
    ..The role of the two different memory CD8+ T cell populations in limiting propagation of the vaccinia gag recombinant virus will be tested by adoptive transfer experiments. ..