rickettsial vaccines

Summary

Summary: Vaccines for the prevention of diseases caused by various species of Rickettsia.

Top Publications

  1. ncbi Cell-mediated immune responses of adults to vaccination, challenge with Rickettsia rickettsii, or both
    J S Dumler
    Department of Pathology and Laboratory Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Trop Med Hyg 46:105-15. 1992
  2. ncbi Some lessons from Rickettsia genomics
    Patricia Renesto
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    FEMS Microbiol Rev 29:99-117. 2005
  3. ncbi Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii
    Qingfeng Li
    Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:130-42. 2005
  4. ncbi Immunization experiments with recombinant Coxiella burnetii proteins in a murine infection model
    Judith Tyczka
    Institute for Infectious Diseases of Animals, Justus Liebig University of Giessen, Frankfurter Str 85 89, D 35392 Giessen, Germany
    Ann N Y Acad Sci 1063:143-8. 2005
  5. ncbi Balb/c mouse model and real-time quantitative polymerase chain reaction for evaluation of the immunoprotectivity against Q fever
    Jingbo Zhang
    Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:171-5. 2005
  6. ncbi Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis
    P A Crocquet-Valdes
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Vaccine 20:979-88. 2001
  7. pmc The realities of biodefense vaccines against Rickettsia
    David H Walker
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Vaccine 27:D52-5. 2009
  8. ncbi Rickettsial vaccines: the old and the new
    Allen L Richards
    Rickettsial Diseases Department, Naval Medical Research Center, RDD IDD Rm 3S04B, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Expert Rev Vaccines 3:541-55. 2004
  9. pmc Discovery of a protective Rickettsia prowazekii antigen recognized by CD8+ T cells, RP884, using an in vivo screening platform
    Michal Gazi
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e76253. 2013
  10. ncbi Enhancement of the antigenic activity and virulence of the vaccine strain E of Rickettsia prow azeki by passages in cell culture
    V F Ignatovich
    Acta Virol 19:481-5. 1975

Research Grants

Scientific Experts

  • Guy Palmer
  • Katelijn Schautteet
  • Mustafa Karatepe
  • Eva Hedfors
  • Hong Ge
  • Pamela Rendi-Wagner
  • Daryl J Kelly
  • J Lindenmann
  • Judith Tyczka
  • Allen L Richards
  • D H Walker
  • Chien Chung Chao
  • F Micoli
  • Abdu Azad
  • Gustavo Valbuena
  • Michal Gazi
  • G Kenitra Hammac
  • Jingbo Zhang
  • Meiling Chen
  • Bohai Wen
  • Dongsheng Niu
  • Yvonne Gar Yun Chan
  • Nowsheen Hamid
  • Eyal Meltzer
  • Richard B Hornick
  • Andrzej Wincewicz
  • Yanmei Jiao
  • Guang Xu
  • Qingfeng Li
  • B Marmion
  • Patricia Renesto
  • Jun Zhang
  • Ling Qiu
  • Jorge Zavala
  • S Tylewska-Wierzbanowska
  • S M Mahan
  • Kelly A Brayton
  • Paula Correa
  • Maria F Galletti
  • Marylin Hidalgo
  • Yenny Góez
  • Maria A Cespedes
  • Glen A Scoles
  • Pei Shin Ku
  • Susan M Noh
  • Erika Caro-Gomez
  • P A Crocquet-Valdes
  • Sean Phillip Riley
  • Emily Chen
  • Juan José Martínez
  • S K Jain
  • Eli Schwartz
  • Sheldon E Greisman
  • Mariola Sulkowska
  • William E Woodward
  • Rudolph Weigl
  • Stanislaw Sulkowski
  • A Nyika
  • S K Dutta
  • A F Barbet
  • M J Burridge
  • I Penttila
  • Suchismita Chattopadhyay
  • Ju Jiang
  • Jean Michel Claverie
  • Wei Mei Ching
  • P Storm
  • Stephane Audic
  • Hiroyuki Ogata
  • Teik Chye Chan
  • K Helbig
  • R Harris
  • L Semendric
  • D Worswick
  • Didier Raoult
  • Alfredo Ruiz
  • Jerzy Chmielowski
  • Zofia Zielińska
  • Rudolf Stefan Weigl
  • K M Kocan
  • Hui Min Feng
  • H Li
  • H M Feng
  • C M Diaz-Montero
  • A D Barrett
  • P Weindling
  • D Kumbula
  • T C McGuire
  • B Biswas
  • R Vemulapalli

Detail Information

Publications47

  1. ncbi Cell-mediated immune responses of adults to vaccination, challenge with Rickettsia rickettsii, or both
    J S Dumler
    Department of Pathology and Laboratory Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Trop Med Hyg 46:105-15. 1992
    ..rickettsii. The relationships between induction of protective immunity against intracellular bacteria by killed and replicating organisms and LT and DTH responses are discussed...
  2. ncbi Some lessons from Rickettsia genomics
    Patricia Renesto
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    FEMS Microbiol Rev 29:99-117. 2005
    ..diagnostic assays, by new antimicrobial drugs, and that could be employed in the generation of future rickettsial vaccines. In this review we present a detailed comparison of the metabolic pathways of these bacteria as well as the ..
  3. ncbi Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii
    Qingfeng Li
    Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:130-42. 2005
    ..The data from this study indicate that fusion antigen P1-HspB is a good immunogen for eliciting immunoresponses against C. burnetii, and it may be a more suitable candidate for preparing subunit vaccine against Q fever...
  4. ncbi Immunization experiments with recombinant Coxiella burnetii proteins in a murine infection model
    Judith Tyczka
    Institute for Infectious Diseases of Animals, Justus Liebig University of Giessen, Frankfurter Str 85 89, D 35392 Giessen, Germany
    Ann N Y Acad Sci 1063:143-8. 2005
    ..In summary, clinical examinations and dissection of mice immunized with the eight recombinant C. b. proteins did not indicate a protective immune response after test infection...
  5. ncbi Balb/c mouse model and real-time quantitative polymerase chain reaction for evaluation of the immunoprotectivity against Q fever
    Jingbo Zhang
    Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:171-5. 2005
    ..The results suggest that the combination of Balb/c model and the real-time quantitative PCR assay is a reliable and sensitive way to evaluate the efficiency of vaccines against Q fever...
  6. ncbi Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis
    P A Crocquet-Valdes
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Vaccine 20:979-88. 2001
    ..Production of IFN-gamma by antigen-exposed T-lymphocytes of DNA vaccine recipients indicated that cellular immunity had been stimulated...
  7. pmc The realities of biodefense vaccines against Rickettsia
    David H Walker
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Vaccine 27:D52-5. 2009
    ..Infection induces long-term immunity, killed rickettsial vaccines stimulate incomplete protection, and a live attenuated mutant stimulates strong immunity but reverts to ..
  8. ncbi Rickettsial vaccines: the old and the new
    Allen L Richards
    Rickettsial Diseases Department, Naval Medical Research Center, RDD IDD Rm 3S04B, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Expert Rev Vaccines 3:541-55. 2004
    ..in the past 20 years no new rickettsial vaccine has been manufactured and there are currently no new or old rickettsial vaccines licensed. Early rickettsial vaccines were difficult, expensive and very hazardous to produce...
  9. pmc Discovery of a protective Rickettsia prowazekii antigen recognized by CD8+ T cells, RP884, using an in vivo screening platform
    Michal Gazi
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e76253. 2013
    ..We report the use of this method to discover a protective T-cell rickettsial antigen, RP884, among a test subset of rickettsial proteins. ..
  10. ncbi Enhancement of the antigenic activity and virulence of the vaccine strain E of Rickettsia prow azeki by passages in cell culture
    V F Ignatovich
    Acta Virol 19:481-5. 1975
    ..The time of the occurrence of these changes in the rickettsial populations varied from 12-18 to 53-102 days of passage of the infected cells...
  11. pmc Protective immunity induced by immunization with a live, cultured Anaplasma marginale strain
    G Kenitra Hammac
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Paul G Allen School for Global Animal Health, Washington State University, Pullman, WA 99164 7040, USA
    Vaccine 31:3617-22. 2013
    ..AmStM-GFP provided clinical protection, yielding a stable PCV and low bacteremia following challenge, whereas A. centrale only afforded partial clinical protection...
  12. ncbi Laboratory-acquired Rocky Mountain spotted fever. The hazard of aerosol transmission
    C N Oster
    N Engl J Med 297:859-63. 1977
    ....
  13. pmc In vitro guinea pig leukocyte reactions to Rickettsia rickettsii
    R H Kenyon
    Infect Immun 18:840-6. 1977
    ..Antibody-treated rickettsiae were phagocytized and destroyed by guinea pig peritoneal macrophages, whereas normal serum-treated rickettsiae replicated and eventually destroyed the phagocytes...
  14. pmc Immune responses to Rickettsia akari infection in congenitally athymic nude mice
    R H Kenyon
    Infect Immun 28:310-3. 1980
    ..This suggests that a T-cell-dependent step is generally necessary to terminate the rickettsialpox infection...
  15. pmc Genome-wide screening and identification of antigens for rickettsial vaccine development
    Guy H Palmer
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology and The Paul G Allen School for Global Animal Health, Washington State University, Pullman, WA 99164 7040, USA
    FEMS Immunol Med Microbiol 64:115-9. 2012
    ....
  16. ncbi Insight into the virulence of Rickettsia prowazekii by proteomic analysis and comparison with an avirulent strain
    Chien Chung Chao
    Viral and Rickettsial Diseases Department Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Biochim Biophys Acta 1774:373-81. 2007
    ..This result suggests the possible relationship between this gene product and the virulence of the strains...
  17. ncbi Short- and long-term immune responses of CD-1 outbred mice to the scrub typhus DNA vaccine candidate: p47Kp
    Guang Xu
    Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Ann N Y Acad Sci 1063:266-9. 2005
    ..Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge...
  18. ncbi Analysis of immunoprotectivity of the recombinant OmpA of Rickettsia heilongjiangensis
    Yanmei Jiao
    Beijing Institute of Microbiology and Epidemiology and State Key Laboratory of Pathogen and Biosecurity, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:261-5. 2005
    ..These results suggest that the truncated OmpA of R. heilongjiangii is immunogenic for effectively inducing humoral and cell-mediated immune responses against homologous and heterologous species in the spotted fever group...
  19. ncbi Cloning and sequence analysis of the 22-kDa antigen genes of Orientia tsutsugamushi strains Kato, TA763, AFSC 7, 18-032460, TH1814, and MAK 119
    Hong Ge
    Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Ann N Y Acad Sci 1063:231-8. 2005
    ..The information gained from this analysis will facilitate our selection of O. tsutsugamushi strains from which antigens should be derived to be included in a multivalent vaccine candidate for scrub typhus...
  20. ncbi Q Fever Research Group (QRG), Adelaide: activities-exit summary 1980-2004
    B Marmion
    Infectious Diseases Laboratories IMVS, University of South Australia, Adelaide, South Australia
    Ann N Y Acad Sci 1063:181-6. 2005
  21. ncbi The reading of scientific texts: questions on interpretation and evaluation, with special reference to the scientific writings of Ludwik Fleck
    Eva Hedfors
    Department of Philosophy and the History of Technology, Royal Institute of Technology, Teknikringen, Stockholm, Sweden
    Stud Hist Philos Biol Biomed Sci 38:136-58. 2007
    ..The restricted possibilities of those not trained in science or not possessing field specific knowledge, evaluating science are discussed, as are also formal aspects of scientific papers and questions related to research ethics...
  22. ncbi Rudolph Weigl (1883-1957)--a scientist in Poland in wartime plus ratio quam vis
    Andrzej Wincewicz
    Department of Pathology, Medical University of Bialystok, Bialystok Poland
    J Med Biogr 15:111-5. 2007
    ..His vaccine saved millions, particularly during World War II. Despite many nominations, he was never awarded the Nobel Prize...
  23. ncbi Enteric fever: an Israeli perspective
    Eyal Meltzer
    Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 9:736-41. 2007
    ..Unfortunately, with the limited efficacy of the current typhoid vaccinations and the increase in multidrug-resistant strains, cases among travelers are expected to continue to increase and become ever challenging to treat...
  24. pmc Characterization of an outer membrane protein of Salmonella enterica serovar typhimurium that confers protection against typhoid
    Nowsheen Hamid
    Department of Biotechnology, Faculty of Science, Hamdard University, New Delhi 110062, India
    Clin Vaccine Immunol 15:1461-71. 2008
    ..An amplified 1.3-kb band was purified and sequenced to confirm its identity. These OMPs provide promising targets for the development of a candidate vaccine against typhoid...
  25. ncbi [The role of Turkish physicians in the vaccination against typhus during the years of World War I]
    Mustafa Karatepe
    Pamukkale Universitesi Tip Fakultesi, Tip Tarihi ve Deontoloji Anabilim Dali, Denizli
    Mikrobiyol Bul 42:301-13. 2008
    ..According to the sources, the claim that some Turkish physicians used the blood of patients with typhus as a means of biological warfare does not reflect the historical truth...
  26. pmc Vi-CRM 197 as a new conjugate vaccine against Salmonella Typhi
    F Micoli
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    Vaccine 29:712-20. 2011
    ..Vi-CRM(197) proved immunogenic in animal studies, even without adjuvant. Thus, Vi-CRM(197) appears to be a suitable candidate for the development of a commercially viable, effective typhoid vaccine for developing countries...
  27. pmc Molecular basis of immunity to rickettsial infection conferred through outer membrane protein B
    Yvonne Gar Yun Chan
    University of Chicago, Department of Microbiology, Chicago, IL 60637, USA
    Infect Immun 79:2303-13. 2011
    ..Considering the evolutionary conservation of rOmpB and its crucial contribution to bacterial invasion of host cells, we propose that rOmpB antibody-mediated killing confers immunity to rickettsial infection...
  28. pmc Chlamydia trachomatis vaccine research through the years
    Katelijn Schautteet
    Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Infect Dis Obstet Gynecol 2011:963513. 2011
    ..trachomatis genital infection despite the many efforts that have been made throughout the years. In this paper, the many attempts to develop a protective vaccine against a genital C. trachomatis infection will be reviewed...
  29. ncbi Doctor T. E. Woodward's legacy: from typhus to typhoid fever
    Richard B Hornick
    Medical Education Administration, Orlando Regional Healthcare System, Orlando, FL 32806, USA
    Clin Infect Dis 45:S6-8. 2007
    ..Subsequently, he was influential in establishing a unique volunteer unit in Maryland in which a wide range of vaccines were evaluated...
  30. ncbi Preliminary studies on the effect of Anaplasma marginale antibodies ingested by Dermacentor andersoni ticks (Acari:Ixodidae) with their blood meal on infections in salivary glands
    K M Kocan
    Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater, 74078, USA
    Exp Appl Acarol 20:297-311. 1996
    ..There was no statistically significant effect of tick exposure to the anti-erythrocytic stage antibody on the development of salivary gland infection or transmission of A. marginale by ticks...
  31. ncbi Between bacteriology and virology: the development of typhus vaccines between the First and Second World Wars
    P Weindling
    Wellcome Unit for the History of Medicine, Oxford, UK
    Hist Philos Life Sci 17:81-90. 1995
    ..This 'paradigm switch' stimulated interest in the possibility of producing an effective medicine...
  32. pmc Protective immunity to heartwater (Cowdria ruminantium infection) is acquired after vaccination with in vitro-attenuated rickettsiae
    F Jongejan
    Department of Tropical Veterinary Medicine and Protozoology, Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands
    Infect Immun 59:729-31. 1991
    ..This is the first report of vaccination with live attenuated C. ruminantium. These attenuated organisms may replace vaccination with virulent blood currently in use in areas where heartwater is endemic...
  33. ncbi Extraction of protective components of Rickettsia rickettsii with n-octyl-beta-D-glucopyranoside
    G A McDonald
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    Rev Infect Dis 10:S382-5. 1988
    ..Vaccination of mice with the detergent-soluble fraction protected them against death caused by R. rickettsii and protected guinea pigs from developing Rocky Mountain spotted fever after being challenged with viable R. rickettsii...
  34. ncbi Development of local morphological changes after intradermal inoculation of Q-fever chemovaccine
    M Resl
    Purkynĕ Medical Research Institute, Hradec Kralove, Czechoslovakia
    Acta Virol 33:167-71. 1989
    ..Interesting was the finding of Kurloff cells in the haemorrhagic foci. The results suggest that the low-reactogenic chemovaccine dose of 0.2 mg might be sufficiently immunogenic after subcutaneous administration...
  35. pmc Vaccine prophylaxis of abattoir-associated Q fever: eight years' experience in Australian abattoirs
    B P Marmion
    Division of Medical Virology, University of Adelaide, South Australia
    Epidemiol Infect 104:275-87. 1990
    ..The Q fever vaccine, unlike other killed rickettsial vaccines, has the property of stimulating long-lasting T lymphocyte memory and this may account for its unusual ..
  36. pmc A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever
    S Vishwanath
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    Infect Immun 58:646-53. 1990
    ..conorii strain and partially protected from experimental infections with a strain of the heterologous species R. rickettsii. These findings show that the 198-kDa R. conorii protein is a candidate for a vaccine against boutonneuse fever...
  37. ncbi Control of rickettsial diseases
    J Kazar
    Institute of Virology, Slovak Academy of Sciences, Bratislava, C S F R
    Eur J Epidemiol 7:282-6. 1991
    ..However, development of subunit vaccines, namely immunogenic rickettsial proteins, cloned and expressed in Escherichia coli, seems to be very promising...
  38. pmc Association of deficiency in antibody response to vaccine and heterogeneity of Ehrlichia risticii strains with Potomac horse fever vaccine failure in horses
    S K Dutta
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park 20742, USA
    J Clin Microbiol 36:506-12. 1998
    ..These studies suggest that the deficiency in the antibody response to the PHF vaccines and the heterogeneity of E. risticii isolates may be associated with the vaccine failure...
  39. ncbi A DNA vaccine protects mice against the rickettsial agent Cowdria ruminantium
    A Nyika
    University of Florida USAID SADC Heartwater Research Project, Harare, Zimbabwe
    Parasite Immunol 20:111-9. 1998
    ..In contrast, survival rates of 0% to 3% (1/144 survivors/total in all control groups) were recorded for control mice. This study demonstrates that MAP1 is a protective antigen and validates the concept of DNA vaccines against heartwater...
  40. ncbi [Immunization recommendations for travel in the Mediterranean area]
    Pamela Rendi-Wagner
    Institut für Spezifische Prophylaxe und Tropenmedizin, Zentrum für Physiologie und Pathophysiologie, Medizinische Universität Wien, Osterreich
    Wien Klin Wochenschr 116:652-60. 2004
    ....
  41. ncbi Mechanisms of immunity against rickettsiae. New perspectives and opportunities offered by unusual intracellular parasites
    Gustavo Valbuena
    Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555 0609, USA
    Microbes Infect 4:625-33. 2002
    ....
  42. ncbi [Spotted fever Rickettsiae. Their immunodominant proteins and immune response]
    Jorge Zavala
    Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Av Itzaes No 490 x 59, CP 97000, Merida Yucatan, Mexico
    Rev Med Chil 132:381-7. 2004
    ..This review covers these topics and provides an overview about the development of vaccines and accessible diagnostic methods for diseases caused by Rickettsia...
  43. ncbi Typhus vaccine developments from the First to the Second World War (on Paul Weindling's 'between bacteriology and virology...')
    Jean Lindenmann
    Medizinische Fakultät Universität Zürich, Obere Geerenstr 34 8044 Gockhausen, Switzerland
    Hist Philos Life Sci 24:467-85. 2002
    ..These developments were not spurned by any 'upswing of virology' but by the threat of typhus in endemic areas and, after 1938, in a war-torn world. Their basis was firmly anchored in bacteriological thought styles and techniques...
  44. ncbi [Rudolf Stefan Weigl--scientist and human being]
    S Tylewska-Wierzbanowska
    Zakład Bakteriologii Państwowego Zakładu Higieny ul Chocimska 24, 00 791 Warszawa
    Przegl Epidemiol 57:225-30. 2003
    ..He and his co-workers introduced first vaccination of medical staff, people from endemic area in Poland and missionaries working in Asia. He was an international authority on prophylactics and control of rickettsial epidemic typhus...
  45. ncbi Hermann Mooser, Typhus, Warsaw 1941
    Jean Lindenmann
    Gesnerus 59:99-113. 2002
    ..Contrary to Weindling's affirmation Mooser was neither in Warsaw in 1941, nor was he a member of the Swiss Sanitary Missions to the eastern front...
  46. ncbi The past and present threat of rickettsial diseases to military medicine and international public health
    Daryl J Kelly
    Department of Molecular Genetics, Ohio State University, Columbus, OH, USA
    Clin Infect Dis 34:S145-69. 2002
    ..The continuation of a proven, highly productive military infectious disease research program is essential for providing solutions to these daunting tasks...
  47. ncbi The inactivated Cowdria ruminantium vaccine for heartwater protects against heterologous strains and against laboratory and field tick challenge
    S M Mahan
    UF USAID SADC Heartwater Research Project, Harare, Zimbabwe
    Vaccine 16:1203-11. 1998
    ....

Research Grants4

  1. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..genes and their inclusion in developing attenuated non-virulent strains for a broad-based protective rickettsial vaccines. To achieve this goal the following Specific Aims are proposed: (1) To clone and characterize genes ..
  3. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  4. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..