air pollutants

Summary

Summary: Substances which pollute the air.

Top Publications

  1. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
  2. pmc Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study
    Dan L Crouse
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 120:708-14. 2012
  3. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
  4. pmc Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality
    Wen Qi Gan
    School of Environmental Health, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 119:501-7. 2011
  5. pmc Nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 11:48. 2012
  6. pmc Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships
    C Arden Pope
    Economics Department, Brigham Young University, Provo, Utah, USA
    Environ Health Perspect 119:1616-21. 2011
  7. pmc Ambient air pollution and the progression of atherosclerosis in adults
    Nino Kunzli
    Swiss Tropical and Public Health Institute Swiss TPH, Basel, Switzerland University of Basel, Basel, Switzerland corrected
    PLoS ONE 5:e9096. 2010
  8. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
  9. pmc Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years
    Frederica P Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:921-6. 2012
  10. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008

Detail Information

Publications366 found, 100 shown here

  1. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
    ..5 microm in aerodynamic diameter [PM2.5]) is limited. Results from the new national monitoring network for PM2.5 make possible systematic research on health risks at national and regional scales...
  2. pmc Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study
    Dan L Crouse
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 120:708-14. 2012
    ..5 μm in aerodynamic diameter (PM(2.5))]. This is the first national-level cohort study to investigate these risks in Canada...
  3. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..It could provide a portal of entry into the CNS for solid UFP, circumventing the tight blood-brain barrier. Whether this translocation of inhaled UFP can cause CNS effects needs to be determined in future studies...
  4. pmc Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality
    Wen Qi Gan
    School of Environmental Health, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 119:501-7. 2011
    ..Epidemiologic studies have demonstrated that exposure to road traffic is associated with adverse cardiovascular outcomes...
  5. pmc Nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 11:48. 2012
    ..We aimed to compare measured and estimated NO₂ levels 12 years apart, the stability of the exposure estimates for members of a large cohort study, and the association of the exposure estimates with natural mortality within the cohort...
  6. pmc Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships
    C Arden Pope
    Economics Department, Brigham Young University, Provo, Utah, USA
    Environ Health Perspect 119:1616-21. 2011
    ..Comparable estimates of the exposure-response relationship for lung cancer are required for disease burden estimates and related public health policy assessments...
  7. pmc Ambient air pollution and the progression of atherosclerosis in adults
    Nino Kunzli
    Swiss Tropical and Public Health Institute Swiss TPH, Basel, Switzerland University of Basel, Basel, Switzerland corrected
    PLoS ONE 5:e9096. 2010
    ..We investigated the association between outdoor air quality and progression of subclinical atherosclerosis (common carotid artery intima-media thickness, CIMT)...
  8. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    ..Yet, little information exists on how effect estimates are impacted by the different exposure assessment methods employed in these studies...
  9. pmc Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years
    Frederica P Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:921-6. 2012
    Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban air pollutants from fossil fuel burning and other combustion sources...
  10. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008
    ..Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts...
  11. ncbi Air pollution and health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, Netherlands
    Lancet 360:1233-42. 2002
    ..In this review, we discuss the evidence for adverse effects on health of selected air pollutants.
  12. pmc Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    Carl Elis Boström
    Swedish Environmental Protection Agency, Stockholm, Sweden
    Environ Health Perspect 110:451-88. 2002
    ..Quantitative cancer risk estimates of PAHs as air pollutants are very uncertain because of the lack of useful, good-quality data...
  13. ncbi Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
    ..The role of exposure to air pollution in the development of allergic sensitization remains unclear...
  14. ncbi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
    ..Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent...
  15. ncbi Stability of measured and modelled spatial contrasts in NO(2) over time
    Marloes Eeftens
    Institute for Risk Assessment Sciences IRAS, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Occup Environ Med 68:765-70. 2011
    ..We tested the stability of measured and modelled spatial contrasts in outdoor nitrogen dioxide (NO(2)) pollution across the Netherlands over 8 years...
  16. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    ..However, studies of health effects of long-term particulate air pollution have been less conclusive...
  17. pmc Are particulate matter exposures associated with risk of type 2 diabetes?
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, 29208, USA
    Environ Health Perspect 119:384-9. 2011
    ..Although studies have found that diabetes mellitus (DM) modifies the impact of exposures from air pollution on cardiovascular outcomes, information is limited regarding DM as an air pollution-associated outcome...
  18. pmc Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach
    Francesca Dominici
    Department of Biostatistics, Harvard University School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:187-94. 2010
    ..health outcomes associated with the exposure to a single air pollutant, adjusted for the exposure to other air pollutants. However, air masses always contain many pollutants in differing amounts, depending on the types of emission ..
  19. pmc An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan
    Kota Katanoda
    Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Epidemiol 21:132-43. 2011
    ..Evidence for a link between long-term exposure to air pollution and lung cancer is limited to Western populations. In this prospective cohort study, we examined this association in a Japanese population...
  20. pmc Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
    Patrick G Goodman
    School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
    Environ Health Perspect 112:179-85. 2004
    ..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
  21. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
    ..Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO 2])...
  22. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008
    ..The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed...
  23. ncbi Long-term exposure to traffic-related air pollution and lung cancer risk
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Epidemiology 19:702-10. 2008
    ..Most studies on the association between lung cancer and air pollution have investigated mortality. There have been few studies of lung cancer incidence...
  24. pmc Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats
    S Takenaka
    Institute for Inhalation Biology, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    Environ Health Perspect 109:547-51. 2001
    ....
  25. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    ..Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences...
  26. pmc Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
    Frederica Perera
    The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
    PLoS ONE 4:e4488. 2009
    ..The results support the emerging theory of early origins of later life disease development...
  27. ncbi Estimating the health effects of exposure to multi-pollutant mixture
    Cécile Billionnet
    Ann Epidemiol 22:126-41. 2012
    ..Because individuals are exposed to many air pollutants at once that are highly correlated with each other, there is a need to consider the multi-pollutant exposure ..
  28. pmc Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1562-8. 2011
    ..RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure...
  29. pmc Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential-the RAPTES project
    Maciej Strak
    National Institute for Public Health and the Environment RIVM, Bilthoven, Netherlands
    Environ Health Perspect 120:1183-9. 2012
    ..High correlations among, and differential measurement errors of, individual components contribute to this uncertainty...
  30. pmc Peat bog wildfire smoke exposure in rural North Carolina is associated with cardiopulmonary emergency department visits assessed through syndromic surveillance
    Ana G Rappold
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1415-20. 2011
    ..Although the association of mortality and morbidity with exposure to urban air pollution is well established, the health effects associated with exposure to wildfire emissions are less well understood...
  31. pmc Temperature and mortality in nine US cities
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 19:563-70. 2008
    Extreme temperatures have been associated with increased mortality worldwide. The extent to which air pollutants may confound or modify this association remains unclear.
  32. ncbi Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project
    K Katsouyanni
    Department of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
    Epidemiology 12:521-31. 2001
    ..Furthermore, they show that the heterogeneity found in the effect parameters among cities reflects real effect modification, which is explained by specific city characteristics...
  33. pmc Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
    Joel D Kaufman
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 176:825-37. 2012
    ..The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD...
  34. pmc Air pollution: mechanisms of neuroinflammation and CNS disease
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    Trends Neurosci 32:506-16. 2009
    ....
  35. ncbi Estimating the national public health burden associated with exposure to ambient PM2.5 and ozone
    Neal Fann
    U S Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, USA
    Risk Anal 32:81-95. 2012
    ..5) and ozone ranges from 3.5% in San Jose to 10% in Los Angeles. These results show that despite significant improvements in air quality in recent decades, recent levels of PM(2.5) and ozone still pose a nontrivial risk to public health...
  36. pmc Airborne particulate matter and mitochondrial damage: a cross-sectional study
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Environ Health 9:48. 2010
    ..Although mitochondria are both the major intracellular source and target of oxidative stress, the effect of PM on mitochondria has never been evaluated in exposed individuals...
  37. pmc Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle
    Jiang Zhou
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:461-6. 2011
    ..Recent toxicological and epidemiological studies have shown associations between particulate matter (PM) and adverse health effects, but which PM components are most influential is less well known...
  38. pmc Socioeconomic position and health status of people who live near busy roads: the Rome Longitudinal Study (RoLS)
    Giulia Cesaroni
    Department of Epidemiology of the Regional Health Service, Lazio Region, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 9:41. 2010
    ..The issue has large public health consequences but few studies have described the main socio-demographic characteristics of people exposed to traffic...
  39. pmc Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA
    Environ Health Perspect 115:989-95. 2007
    ..Although numerous studies have demonstrated links between particulate matter (PM) and adverse health effects, the chemical components of the PM mixture that cause injury are unknown...
  40. pmc Residential proximity to freeways and autism in the CHARGE study
    Heather E Volk
    Department of Preventive Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, Children s Hospital Los Angeles, University of Southern California, Los Angeles, California 90033, USA
    Environ Health Perspect 119:873-7. 2011
    ..Traffic-related air pollution, a common exposure with established effects on these pathways, contains substances found to have adverse prenatal effects...
  41. ncbi Near-roadway air quality: synthesizing the findings from real-world data
    Alex A Karner
    U C Davis Caltrans Air Quality Project, Department of Civil and Environmental Engineering, University of California, Davis, California 95616, USA
    Environ Sci Technol 44:5334-44. 2010
    ..g., benzene, nitrogen dioxide); or no trend with distance (e.g., particulate matter mass concentrations)...
  42. pmc Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Healt, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Pediatrics 124:e195-202. 2009
    ..This study evaluated the relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and child intelligence...
  43. pmc Ambient air pollution and risk for ischemic stroke and transient ischemic attack
    Lynda D Lisabeth
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    Ann Neurol 64:53-9. 2008
    ..The objective of this study was to investigate the association between short-term exposure to ambient air pollution and risk for ischemic cerebrovascular events in a US community...
  44. pmc Diabetes incidence and long-term exposure to air pollution: a cohort study
    Zorana J Andersen
    1Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Diabetes Care 35:92-8. 2012
    ..We studied the association between long-term exposure to traffic-related air pollution and incidence of diabetes...
  45. ncbi Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects
    Joellen Lewtas
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 4695, USA
    Mutat Res 636:95-133. 2007
    ....
  46. pmc Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China
    Haidong Kan
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
    Environ Int 33:376-84. 2007
    ..5) and coarse particles (PM10-2.5) remain inconsistent. In China, PM2.5 and PM10-2.5 are not the criteria air pollutants, and their monitoring data are scarce. There have been no epidemiological studies of health effects of PM2...
  47. ncbi Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and youn
    LILIAN CALDERON-GARCIDUENAS
    Instituto Nacional de Pediatria, Mexico City, Mexico
    Toxicol Pathol 36:289-310. 2008
    ..Exposure to air pollution should be considered a risk factor for Alzheimer's and Parkinson's diseases, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer's disease if they reside in a polluted environment...
  48. pmc Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
    Kazuhiko Ito
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:467-73. 2011
    ..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
  49. pmc Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods
    Jeremy A Sarnat
    Rollins School of Public Health of Emory University, Department of Environmental and Occupational Health, 1518 Clifton Rd, Room 260, Atlanta, GA 30322, USA
    Environ Health Perspect 116:459-66. 2008
    ..We analyzed a time-series of chemically speciated PM measurements in Atlanta, Georgia, and conducted an epidemiologic analysis using data from three distinct source-apportionment methods...
  50. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland
    Susan Claire Edwards
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 118:1326-31. 2010
    In this prospective cohort study of Caucasian mothers and children in Krakow, Poland, we evaluated the role of prenatal exposure to urban air pollutants in the pathogenesis of neurobehavioral disorders.
  51. ncbi Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
    Sarah B Henderson
    School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, British Columbia, Canada
    Environ Sci Technol 41:2422-8. 2007
    ..62 and were similar across traffic metrics. Resulting maps show the distribution of NO to be more heterogeneous than that of NO2, supporting the usefulness of this approach for assessing spatial patterns of traffic-related pollution...
  52. pmc Air pollution from traffic and cancer incidence: a Danish cohort study
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health 10:67. 2011
    ..Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer...
  53. pmc Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8
    Amy E Kalkbrenner
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Epidemiology 21:631-41. 2010
    Hazardous air pollutants are plausible candidate exposures for autism spectrum disorders. They have been explored in recent studies for their role in the development of these disorders.
  54. ncbi An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community
    Ryan W Allen
    Simon Fraser University, Faculty of Health Sciences, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Am J Respir Crit Care Med 183:1222-30. 2011
    ..Particulate air pollution is associated with cardiovascular morbidity. One hypothesized mechanism involves oxidative stress, systemic inflammation, and endothelial dysfunction...
  55. pmc The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS): study design and methods
    Alan Vette
    United States Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Dr, RTP, NC 27711, USA
    Sci Total Environ 448:38-47. 2013
    The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS) was designed to examine the relationship between near-roadway exposures to air pollutants and respiratory outcomes in a cohort of asthmatic children who live close ..
  56. ncbi Air pollution and hospital admissions for pneumonia in a subtropical city: Taipei, Taiwan
    Hui Feng Chiu
    Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan
    Inhal Toxicol 21:32-7. 2009
    ..On cool days, PM(10), CO, and O(3) remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for pneumonia.
  57. pmc Autism spectrum disorders in relation to distribution of hazardous air pollutants in the san francisco bay area
    Gayle C Windham
    Division of Environmental and Occupational Disease Control, California Department of Health Services, Richmond, California, USA
    Environ Health Perspect 114:1438-44. 2006
    ..S. Environmental Protection Agency...
  58. ncbi Effects of nitrogen dioxide on human health: systematic review of experimental and epidemiological studies conducted between 2002 and 2006
    Ute Latza
    Institute for Occupational Medicine and Maritime Medicine ZfAM, University of Hamburg, Hamburg State Department for Social Affairs, Family, Health, and Consumer Protection, Hamburg, Germany
    Int J Hyg Environ Health 212:271-87. 2009
    ..The effect remained after adjusting for other air pollutants. There was moderate evidence that short-term exposure below a 24-h mean value of 50 microg NO(2)/m(3) at ..
  59. pmc The temporal lag structure of short-term associations of fine particulate matter chemical constituents and cardiovascular and respiratory hospitalizations
    Sun Young Kim
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Environ Health Perspect 120:1094-9. 2012
    ..5 µm in aerodynamic diameter) and health end points has been observed to vary by disease category. The lag pattern of PM2.5 chemical constituents has not been well investigated, largely because daily data have not been available...
  60. pmc Traffic-related air toxics and term low birth weight in Los Angeles County, California
    Michelle Wilhelm
    Department of Epidemiology, School of Public Health, University of California Los Angeles, 650 Charles E Young Dr, Los Angeles, CA 90095, USA
    Environ Health Perspect 120:132-8. 2012
    Numerous studies have linked criteria air pollutants with adverse birth outcomes, but there is less information on the importance of specific emission sources, such as traffic, and air toxics.
  61. pmc Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States
    Keita Ebisu
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 120:1746-52. 2012
    Previous studies on air pollutants and birth outcomes have reported inconsistent results. Chemical components of particulate matter ≤ 2.5 µm (PM2...
  62. pmc Modeling the association between particle constituents of air pollution and health outcomes
    Elizabeth Mostofsky
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 176:317-26. 2012
    ..5. Although the different methods yield results with different interpretations, the relative rankings of the association between constituents and ischemic stroke were fairly consistent across models...
  63. pmc Blood pressure response to controlled diesel exhaust exposure in human subjects
    Kristen E Cosselman
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA
    Hypertension 59:943-8. 2012
    ..This controlled trial in humans confirms findings from observational studies. The effect may be important on a population basis given the worldwide prevalence of exposure to traffic-related air pollution...
  64. ncbi Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster
    A Nemmar
    Laboratory of Pneumology, Center for Molecular and Vascular Biology, K.U.Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 164:1665-8. 2001
    ..We conclude that a significant fraction of (99m)Tc-albumin, taken as a model of ultrafine particles, rapidly diffuses from the lungs into the systemic circulation...
  65. pmc Distributed lag analyses of daily hospital admissions and source-apportioned fine particle air pollution
    Ramona Lall
    New York University, School of Medicine, Department of Environmental Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:455-60. 2011
    ..5 µm (PM2.5)] have used chemically nonspecific PM2.5 mass. However, PM2.5 is known to vary in chemical composition with source, and health impacts may vary accordingly...
  66. ncbi Extreme air pollution events from bushfires and dust storms and their association with mortality in Sydney, Australia 1994-2007
    Fay Johnston
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart 7001, Tasmania, Australia
    Environ Res 111:811-6. 2011
    ..We examined the association between air pollution events and mortality in Sydney from 1997 to 2004...
  67. ncbi Local determinants of road traffic noise levels versus determinants of air pollution levels in a Mediterranean city
    Maria Foraster
    Centre for Research in Environmental Epidemiology CREAL, Barcelona Biomedical Research Park, Dr Aiguader, 88 08003 Barcelona, Spain
    Environ Res 111:177-83. 2011
    ..Few studies have investigated their correlation - none in Spain - and results differ among cities...
  68. pmc Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US counties, 1999-2005
    Michelle L Bell
    Yale University, New Haven, CT 06511, USA
    Am J Epidemiol 168:1301-10. 2008
    ..Results can help guide development of hypotheses and further epidemiologic studies on potential heterogeneity in the toxicity of constituents of the particulate matter mixture...
  69. ncbi Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages
    Margot Lundborg
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Environ Res 100:197-204. 2006
    ..Such an effect may contribute to increased susceptibility to infections and, for example, result in more exacerbations of asthma and chronic obstructive pulmonary disease...
  70. ncbi Relations between PM10 composition and cell toxicity: a multivariate and graphical approach
    Irma Rosas Pérez
    Laboratorio de Aerobiología, Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, DF, Mexico
    Chemosphere 67:1218-28. 2007
    ..Radial plots suggest the existence of complex interactions between components, resulting in characteristic patterns of toxicity by site. We conclude that interactions of PM(10) components determine specific cellular outcomes...
  71. ncbi Air temperature and the occurrence of myocardial infarction in Augsburg, Germany
    Kathrin Wolf
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Circulation 120:735-42. 2009
    ..The objective of this study was to examine in detail the registry-based myocardial infarction (MI) rates and coronary deaths in relation to air temperature in the area of Augsburg, Germany...
  72. pmc Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors
    Monica Guxens
    Center for Research in Environmental Epidemiology, Carrer Dr Aiguader 88, Barcelona, Catalonia, Spain
    Environ Health Perspect 120:144-9. 2012
    ..Air pollution effects on children's neurodevelopment have recently been suggested to occur most likely through the oxidative stress pathway...
  73. ncbi Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies
    Susanne Becker
    US Environmental Protection Agency, Human Studies Facility, National Health and Environmental Effects Research Laboratory, Research Triangle Park, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 207:269-75. 2005
    ..Exposure to coarse and fine PM decreased the expression of TLR4 in the macrophages. Particle-induced decrease in TLR4 and hyporesponsiveness to LPS may be related to LPS tolerance induced by low levels of LPS...
  74. ncbi Air pollution and birth outcomes: a systematic review
    Prakesh S Shah
    Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    Environ Int 37:498-516. 2011
    Several mechanisms are suspected to underlie adverse birth outcomes among mothers exposed to air pollutants, including inflammation, direct toxic effects on fetuses and the placenta, displacement of the oxygen-hemoglobin dissociation ..
  75. pmc Vulnerability to heat-related mortality in Latin America: a case-crossover study in Sao Paulo, Brazil, Santiago, Chile and Mexico City, Mexico
    Michelle L Bell
    EnvironmentalHealth, Yale University, New Haven, CT06511, USA
    Int J Epidemiol 37:796-804. 2008
    ..Factors affecting vulnerability to heat-related mortality are not well understood. Identifying susceptible populations is of particular importance given anticipated rising temperatures from climatic change...
  76. pmc Philip Morris toxicological experiments with fresh sidestream smoke: more toxic than mainstream smoke
    S Schick
    Center for Tobacco Control Research and Education, Division of Cardiology, University of California, San Francisco, California, USA
    Tob Control 14:396-404. 2005
    ..Exposure to secondhand smoke causes lung cancer; however, there are little data in the open literature on the in vivo toxicology of fresh sidestream cigarette smoke to guide the debate about smoke-free workplaces and public places...
  77. pmc Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition
    Srimathi Kannan
    Department of Environmental Health Sciences, Human Nutrition Program, University of Michigan, Ann Arboe, Michigan 48109 2029, USA
    Environ Health Perspect 114:1636-42. 2006
    ....
  78. pmc The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003
    R J Delfino
    Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
    Occup Environ Med 66:189-97. 2009
    ..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated...
  79. ncbi Referent selection in case-crossover analyses of acute health effects of air pollution
    D Levy
    Department of Epidemiology, University of Washington, Seattle 98195-7232, USA
    Epidemiology 12:186-92. 2001
    ..In addition, conditional logistic regression analysis is not strictly valid for some case-crossover designs, introducing further bias...
  80. ncbi Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries
    Gregory A Wellenius
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Stroke 36:2549-53. 2005
    ..The association between short-term elevations in ambient air particles and increased cardiovascular morbidity and mortality is well documented. Ambient particles may similarly increase the risk of stroke...
  81. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    ..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...
  82. pmc Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution
    Peter Møller
    Department of Public Health, Section of Environment Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 118:1126-36. 2010
    ..Air pollution is thought to exert health effects through oxidative stress, which causes damage to DNA and lipids...
  83. pmc Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study
    Francine Laden
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Respir Crit Care Med 173:667-72. 2006
    ..A large body of epidemiologic literature has found an association of increased fine particulate air pollution (PM2.5) with acute and chronic mortality. The effect of improvements in particle exposure is less clear...
  84. pmc Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources
    Michelle L Bell
    Yale University, School of Forestry and Environmental Studies, New Haven, CT 06511, USA
    Epidemiology 21:884-91. 2010
    ..Exposure to fine particles (PM2.5) during pregnancy has been linked to lower birth weight; however, the chemical composition of PM2.5 varies widely. The health effects of PM2.5 constituents are unknown...
  85. pmc Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study
    Edith H van den Hooven
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:150-6. 2012
    ..Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth...
  86. ncbi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  87. ncbi Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children
    Roya Kelishadi
    Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Atherosclerosis 203:311-9. 2009
    ..Reaching a better understanding of the modifiable factors associated with inflammatory and oxidative biomarkers in children would be relevant to the design of further investigation and prevention strategies...
  88. ncbi Ambient air pollution and cardiovascular emergency department visits
    Kristi Busico Metzger
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Epidemiology 15:46-56. 2004
    Despite evidence supporting an association between ambient air pollutants and cardiovascular disease (CVD), the roles of the physicochemical components of particulate matter (PM) and copollutants are not fully understood...
  89. pmc Maternal personal exposure to airborne benzene and intrauterine growth
    Remy Slama
    INSERM, Institut National de la Sante et de la Recherche Medicale, University J Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, U823, Institut Albert Bonniot, Grenoble, France
    Environ Health Perspect 117:1313-21. 2009
    Studies relying on outdoor pollutants measures have reported associations between air pollutants and birth weight.
  90. pmc Short-term associations between ambient air pollutants and pediatric asthma emergency department visits
    Matthew J Strickland
    Department of Environmental and Occupational Health, Atlanta, GA 30322, USA
    Am J Respir Crit Care Med 182:307-16. 2010
    Certain outdoor air pollutants cause asthma exacerbations in children...
  91. pmc Air pollution and emergency admissions in Boston, MA
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Epidemiol Community Health 60:890-5. 2006
    ..5) is now the particle measure of greatest health and regulatory concern. And little has been published on associations of hospital admissions and PM components...
  92. pmc Childhood lymphohematopoietic cancer incidence and hazardous air pollutants in southeast Texas, 1995-2004
    Kristina W Whitworth
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, Houston, Texas, USA
    Environ Health Perspect 116:1576-80. 2008
    Cancer is the second leading cause of death among U.S. children with few known risk factors. There is increasing interest in the role of air pollutants, including benzene and 1,3-butadiene, in the etiology of childhood cancers.
  93. pmc Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China
    Shunqin Wang
    Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing, People s Republic of China
    Environ Health Perspect 117:1612-8. 2009
    ..However, few data have been reported on the effects on neurobehavioral function in children...
  94. pmc Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study
    Evangelia Samoli
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Environ Health Perspect 116:1480-6. 2008
    ..S. NMMAPS (National Morbidity, Mortality and Air Pollution Study) projects, along with Canadian data...
  95. pmc Case-crossover analysis of air pollution health effects: a systematic review of methodology and application
    Eduardo Carracedo-Martínez
    Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain
    Environ Health Perspect 118:1173-82. 2010
    ..Case-crossover is one of the most used designs for analyzing the health-related effects of air pollution. Nevertheless, no one has reviewed its application and methodology in this context...
  96. ncbi Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))
    S F Van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:826-30. 2001
    ..Identified cytokines were also measured in the circulation of healthy young subjects exposed to air pollutants during the 1997 Southeast Asian forest fires...
  97. ncbi Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicology 262:50-6. 2009
    ..We conclude that, in SHR, the presence of DEP in the systemic circulation leads not only to cardiac and systemic changes, but also triggers pulmonary inflammatory reaction involving IL-6, LTB4 and oxidative stress...
  98. pmc A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada
    Michael Jerrett
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California 94720 7360, USA
    Environ Health Perspect 117:772-7. 2009
    ..Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic...
  99. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth...
  100. ncbi Inflammatory lung injury after bronchial instillation of air pollution particles
    A J Ghio
    Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27599 7315, USA
    Am J Respir Crit Care Med 164:704-8. 2001
    ..Findings suggest that mass may not be the most appropriate metric to use in assessing health effects after PM exposure but rather specific components must be identified and assessed...
  101. ncbi Inhaled particles and lung cancer, part B: paradigms and risk assessment
    Paul J A Borm
    Particle Research, Institut fur Umweltmedizinische Forschung, Heinrich Heine University Dusseldorf, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    Int J Cancer 110:3-14. 2004
    ..Apart from such bridging studies, further focus is also needed on surface chemistry and modifications in relation to their adverse biologic effects...

Research Grants72

  1. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..The first research objective is to characterize the concentration and composition of ambient air pollutants at 2 high schools in Atlanta during time periods when students are engaged in physical activities...
  2. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..With increased evidence that air pollutants act to exacerbate CVD, it is important to determine the mechanisms responsible for the exacerbation of ..
  3. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..An important group of toxicants, as defined by the U.S. Environmental Protection Agency (EPA), are hazardous air pollutants, or HAPs (e.g., benzene, diesel particulate matter)...
  4. Gene expression responses to air pollution and modification by genetic variation
    Sharine Wittkopp; Fiscal Year: 2013
    ..relevant to pathophysiological mechanisms involved in acute peripheral vascular responses to particulate air pollutants. The aims of this study are to evaluate relations between peripheral blood gene expression and air pollution ..
  5. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..For instance, disproportionately higher number of African Americans and Hispanics are likely to be exposed to air pollutants compared to Caucasians that is one of the major factors that contribute to the health disparities seen in ..
  6. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..It remains one of the most problematic air pollutants to control because it is formed from intermediates originating from many different sources...
  7. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..Epidemiological studies have clearly shown that asthma exacerbation linked to air pollutants is a major cause of asthma exacerbation...
  8. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    ..Clinical and experimental research suggests that air pollutants can acutely induce a vasoconstrictive mechanism, though a clear connection between such studies and the ..
  9. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..We hypothesize that maternal exposure to traffic-related air pollutants during pregnancy results in reductions in fetal growth, and that part of these impacts are seen early in ..
  10. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..This grant will address the pressing question of whether air pollutants can acutely alter human antimycobacterial immunity...
  11. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..As a disease that has been linked to environmental triggers such as pollen and air pollutants, it is crucial that we study its pathogenesis...
  12. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..Specifically, we will investigate later-life exposure to ambient air pollutants as novel environmental determinants of cognitive aging in a susceptible population of older women...
  13. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..adolescents to examine the mediating effect of diet (not available in Add Health) and the modifying effects of air pollutants (also not available in the Add Health study) on the stress-cardiovascular health relationship...
  14. Hydroxynonenal induces glutathione synthesis through JNK
    Henry Jay Forman; Fiscal Year: 2010
    ..damage is a major component of lung injury during inflammation, other respiratory diseases and in exposure to air pollutants. The endogenous antioxidant glutathione increases during adaptation to sublethal oxidative stress through ..
  15. Inhibition of lung defense by air pollutant particulates
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..This will help us to devise regulations for air pollutants and to determine risk for infection caused by air pollution and to devise intervention strategies.
  16. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..The samples will be analyzed using an automated energy dispersive XRF instrument. . ..
  17. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ..Dietary factors may play a modulating role on effects of air pollutants. This investigative team leveraged the Harvard Programming of Intergenerational Stress Mechanisms (PRISM) ..
  18. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..We postulate that inflammatory endothelial activation arises following inhalation of air pollutants due to oxidative modifications of blood components, and reflects a common mode of action for many pollutants...
  19. Transcriptomic, Oxidative Stress, and Inflammatory Responses to Air Pollutants
    Ralph J Delfino; Fiscal Year: 2013
    ..would be among the first using repeated measurements to analyze the relation between chemically characterized air pollutants and genome-wide gene expression patterns in peripheral blood cells from a high- risk population of elderly ..
  20. Climate Variability / Change and the Risks for a Spectrum of Diseases
    Shao Lin; Fiscal Year: 2011
    ..and maternal/infant characteristics will be controlled and the interactive effects between climate factors and air pollutants will be assessed...
  21. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..provided by applicant): While increasing evidence suggests that maternal exposure to high levels of ambient air pollutants during pregnancy plays a critical role in producing adverse pregnancy outcomes, most of the early studies ..
  22. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    Environmental exposure to fundamentally diverse agonists such as bacteria and air pollutants can signal through shared mechanisms to activate the innate immune system...
  23. Mutagenesis of p53 by reactive PAH and ROS
    JEFFREY M FIELD; Fiscal Year: 2012
    Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental air pollutants that result from fossil fuel combustion and cigarette smoking. PAH exposure is a major risk factor in human lung carcinogenesis...
  24. Household air pollution in Tanzania, placental health and pregnancy outcome
    BLAIR JOHNSON WYLIE; Fiscal Year: 2013
    ..While the candidate's research efforts during the career development period will focus on air pollutants, techniques and methodologies they will learn will be translatable to the evaluation of obstetric risks ..
  25. Air Pollution and Cognitive Aging Among Older Women
    Jennifer Weuve; Fiscal Year: 2010
    ..We will evaluate whether long-term exposure to each of the 3 air pollutants-thoracic, fine and traffic particles-is related to cognitive decline among older women...
  26. Allergic asthma and chromium exposure
    Steven R Patierno; Fiscal Year: 2010
    ..One reason is that workers in the chromium industry are co-exposed to many occupational air pollutants, making it difficult to conclude which specific pollutant(s) is responsible for promoting asthma development...
  27. Effect of Air Pollution and Traffic on Birth Outcomes
    Michelle L Bell; Fiscal Year: 2012
    ..Since all exposure assessments have some limitations, we propose four methods to measure exposure to air pollutants: central site monitors;a GIS/traffic model;land use regression to measure NO2 exposure;and satellite imagery ..
  28. Effects of particulate air pollution on HDL function and atherosclerosis
    JESUS ANTONIO ARAUJO; Fiscal Year: 2013
    ..Cumulative epidemiological and experimental data have shown that exposure to air pollutants lead to increased cardiovascular ischemic events and enhanced atherosclerosis...
  29. Air Pollution and Peripheral Blood Gene Expression in Subjects with Coronary Arte
    Ralph J Delfino; Fiscal Year: 2010
    ..quantitative PCR to test the expression of 42 key genes expected to be up- or down-regulated in response to air pollutants. Genes will include those involved in oxidative stress, antioxidant defense, xenobiotic metabolism, ..
  30. Home and community exposures in COPD exacerbation: A pilot case cross-over study
    Susan R Sama; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: We hypothesize that air pollutants associated with asthma and other acute respiratory effects in the home, community and workplace may trigger ..
  31. DNA damage recognition by nucleotide excision repair proteins
    Bennett Van Houten; Fiscal Year: 2013
    ..to humans that removes a wide variety of DNA lesions caused by environmental agents such as UV light and air pollutants. In addition, NER is important for the removal of adducts induced by several anticancer drugs, such as ..
  32. Assessing the Cumulative Climate-Related Health Risks in the Eastern U.S.
    Yang Liu; Fiscal Year: 2011
    ..project aims at characterizing the cumulative health risks of three climate-change related stressors: ambient air pollutants including ozone and PM2.5, heat waves, and vectorborne diseases (i.e., Lyme disease)...
  33. Neurodevelopment in Urban Environments: Role of Exposure to Ambient Air Pollution
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..health scientists have generated compelling data on neurotoxicity in animals and humans exposed to present-day air pollutants from road traffic emissions (or traffic air pollution [TAP]), including particulate matter and ozon in urban ..
  34. Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
    Frank D Gilliland; Fiscal Year: 2011
    ..differences in lung function growth, and 3) susceptibility for adverse respiratory effects of ambient air pollutants. The proposed program of research builds on the rich health, exposure and genetic data resources of the ..
  35. Inflammatory Cytokine Polymorphisms, Air Pollution, and Very Preterm Birth
    Ondine von Ehrenstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We proposes to examine the hypotheses that maternal exposure to air pollutants during pregnancy is associated with an increased risk of very preterm birth (VPTB, <32 weeks gestation), and that ..
  36. The interaction of diet, air pollution, and cardiovascular disease in NHANES.
    Terry Gordon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Long-term and short-term exposures to ambient air pollutants, particularly particulate matter (PM), have been linked to cardiovascular disease (CVD)...
  37. Exposure to mobile source air pollution and adverse birth outcomes in the Los Ang
    Jun Wu; Fiscal Year: 2009
    ..aims are as follows: 1) To determine the association of mothers'residential exposure to traffic-related air pollutants with LBW and PTD in a large retrospective cohort...
  38. Wood Smoke and Genetic Susceptibility to Asthma in An Honduran Population
    Joshua Mark Galanter; Fiscal Year: 2013
    ..He will measure household and personal exposure levels of common air pollutants, characterize inflammatory biomarkers and metabolites of exposure to smoke, and perform a detailed asthma ..
  39. Neural stem cell susceptibility to ambient particulate matter over the lifespan
    Colleen Cosgrove Hegg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Environmental air pollutants adversely affect cognition and cause progressive neurodegeneration through unknown mechanisms...
  40. Early Life Exposures to Air Toxics and the Risk of Early Childhood Leukemia
    Elaine Symanski; Fiscal Year: 2013
    ..Combined effects of these air pollutants will also be evaluated...
  41. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013
    ..We hypothesize that elevations in short-term exposure to air pollutants (fine particulate matter, black carbon, ozone, nitrogen oxides, sulfates and metals) will impair lung function ..
  42. Air pollution and risk of incident hypertension and diabetes in U.S. black women
    Patricia F Coogan; Fiscal Year: 2013
    ..We will use the newly developed spatial cohort survival modeling technique to account for clustering of air pollutants at two geographic levels, regional and local...
  43. Acute Asthma Outcomes, Endotoxin and Oxidative Potential of Pollutant Particles
    Ralph J Delfino; Fiscal Year: 2012
    ..Health outcomes will include airway inflammation (exhaled nitric oxide) and expiratory lung function. Air pollutants will include personal exposure to NO2 and to PM2.5 mass, elemental carbon, and organic carbon...
  44. Air Pollution, Intima-media Thickness, and Lung Function in College Students
    Edward Avol; Fiscal Year: 2010
    ..The American Heart Association recommends focusing on prevention of atherosclerosis in early life. Air pollutants represent ubiquitous inflammatory exposures, and millions of young Americans live in areas that exceed current ..
  45. The Physiologic Response to Weather Changes and Extremes in an Elderly Cohort
    Joel D Schwartz; Fiscal Year: 2012
    ..Each subject in this cohort has also been well characterized for their daily exposure to air pollutants. To account for the repeated measurements on each subject, the project will employ multivariate mixed ..
  46. PULMONARY EFFECTS OF ENVIRONMENTAL OXIDANT POLLUTANTS
    DALLAS MELVIN HYDE; Fiscal Year: 2010
    ..response of the mammalian respiratory system to the inhalation of ambient concentrations of oxidant air pollutants. The focus of this renewal application will be on mechanisms of environmentally induced asthma in young ..
  47. Vulnerability to Health Effects of Wildfires under a Changing Climate in Western
    Michelle L Bell; Fiscal Year: 2013
    ..Scientific literature on ambient air pollutants indicates that some populations are more vulnerable than others to health responses...
  48. Tracking Air Pollutants and Newborn Health in Houston, Texas
    Elaine Symanski; Fiscal Year: 2011
    ..The region's documented poor air quality is influenced by multiple sources of air pollutants due to extensive road traffic and proximity to one of the largest petrochemical industrial complexes in the U...
  49. DNA Methylation as a Biomarker of Exposure and Effect for Particles and Metals
    Joel D Schwartz; Fiscal Year: 2013
    ..research in Environmental Epigenetics and expand the work to discover and validate biomarkers of exposure to air pollutants and toxic metals...
  50. Smart Miniaturized personal monitors for black carbon and multiple air pollutants
    Steven N Chillrud; Fiscal Year: 2010
    ..The final smart air pollution monitor will incorporate upgrades suggested by the latest field-testing. ..
  51. Symposium on Air Pollution and Cardiovascular Disease
    JOEL DANIEL KAUFMAN; Fiscal Year: 2010
    ..will provide a scientific forum for presenting recent findings related to the cardiovascular effects of air pollutants. This symposium will bring together leading investigators in the area and facilitate interactions and critical ..
  52. Children's Environmental Health Center
    Frank D Gilliland; Fiscal Year: 2010
    ..Important contributions were made supporting the growing consensus that current levels of ambient air pollutants and tobacco smoke have substantial adverse effects on children's respiratory health, especially among ..
  53. Air pollution, stress and urban child development
    Rosalind J Wright; Fiscal Year: 2013
    ..Finally, to further explore biological mechanisms by which air pollutants and stress impact neurodevelopment, genetic susceptibility factors will be examined...
  54. Effects of Traffic Pollution on Lung Immunity and Pneumonia in Persons with HIV
    Robert J Blount; Fiscal Year: 2013
    ..Therefore we propose to study the effects of air pollutants on lung immunity and susceptibility to pulmonary infection in those with HIV...
  55. Formaldehyde and Other Pollutants from Ozone Reactions on Ventilation Systems
    Hugo Destaillats; Fiscal Year: 2010
    ..Harmful indoor air pollutants such as formaldehyde and ultrafine aerosol particles can be generated in ozone reactions with particle-laden ..
  56. Ambient PM2.5 and ETS exposure: interactive health effects for asthmatic children
    Matthew J Strand; Fiscal Year: 2010
    ..In this proposed work, exposures to two air pollutants from differences sources (one ambient, one mainly non-ambient) will be modeled...
  57. Prenatal air pollution, DNA methylation and early signs of atherosclerosis
    CARRIE VAN DOREN BRETON; Fiscal Year: 2013
    ..to the rapidly evolving field of environmental epigenomics by investigating novel associations between air pollutants, DNA methylation, and early life atherogenesis...
  58. Air Pollution and Preclinical Atherosclerosis in Elementary-School Children
    Edward Avol; Fiscal Year: 2009
    ..This project pursues the hypothesis that long-term exposure to local and regional air pollutants from outdoor origin promotes atherogenesis in early life, leading to differences in CIMT in 10-12yr old ..
  59. Effects of Traffic-Related Air Pollution on Cognitive Function, Dementia Risk, an
    JOEL DANIEL KAUFMAN; Fiscal Year: 2011
    ..study on air pollution and risk of cardiovascular disease, we will expand upon estimates of exposure to air pollutants produced by vehicle emissions to evaluate the relationship between air pollution and neurological outcomes...
  60. Extracellular Matrix, Innate Immunity, and Ozone-induced Airways Disease
    John W Hollingsworth; Fiscal Year: 2013
    ..toxins, understanding the biologic mechanisms that regulate the patho-physiologic responses to common ambient air pollutants is of considerable interest to human health...
  61. Rapid Real-Time High-Sensitivity Trichloroethylene Vapor Analyzer
    BRUCE ARAM RICHMAN; Fiscal Year: 2013
    ..analyzer design resulting from this project to many different trace gases, including atmospheric and indoor-air pollutants, and combinations of trace gases...
  62. Mechanisms of Species-Dependent Environmental Lung Injury
    Edward M Postlethwait; Fiscal Year: 2010
    ..Approximately half of the United States population continues to be impacted by pathogenic air pollutants such as ozone (O3), which recent epidemiologic studies suggest induces long term functional impairments in ..
  63. Health, Pollution & Economic Development in South Durban
    Stuart Batterman; Fiscal Year: 2004
    ..studies indicate high levels of respiratory disease among children in the area and strong evidence that air pollutants are associated with acute changes in health status for children with moderate to severe asthma...
  64. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ..about adverse developmental effects in infants and young children from prenatal exposure to environmental air pollutants, including polycyclic aromatic hydrocarbons (PAH), particulate matter (PM2...
  65. Air Pollution and Asthma in Southeast Louisiana
    BADIOLLAH ASRABADI; Fiscal Year: 2002
    ..provider in Southeast Louisiana, proposes this project for a comprehensive study to identify asthma-triggering air pollutants in Southeast Louisiana...
  66. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..Adapted from the applicant's abstract): The respiratory tract is commonly exposed to a variety of oxidizing air pollutants, such as ozone, nitrogen dioxide or cigarette smoke, which can induce inflammatory responses in the ..
  67. Ambient Air Toxics and Adverse Birth Outcomes
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..However, to date almost all existing studies have focused on criteria air pollutants (CO, NOx, particles, SO2) rather than specific air toxics and have used data from existing government air ..
  68. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    The pro-inflammatory role of air pollutants and their modifying influence on allergic inflammation may partly explain the increase in asthma prevalence, morbidity, and mortality...
  69. EFFECTS OF AMBIENT AIR POLLUTANTS ON ANNUAL MORTALITY
    George Thurston; Fiscal Year: 2001
    ..of the mortality experience of the ACS prospective cohort population in relation to ambient concentrations of air pollutants in the communities in which they reside. In addition to the PM2...
  70. DOES PULMONARY SURFACTANT REACT WITH INHALED POLLUTANTS?
    BARBARA FINLAYSON PITTS; Fiscal Year: 1993
    ..as much as 30% of the fatty acids are unsaturated, presenting potential reaction sites for inhaled oxidant air pollutants. While inhalation of such pollutants as 03 is known to cause a change in the chemical composition of PS, it is ..
  71. Exposure to Indoor Air Pollutants and Birth Outcomes
    Amna Siddiqui; Fiscal Year: 2005
    ..Since use of wood is prevalent and risk of LBW is high, this study will explain a large proportion of LBW. Results will have significant implications of preventing this outcome. ..
  72. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1991
    ..this project is to elucidate further the potential human toxicity of inhalation of these wide spread serious air pollutants. The specific pollutants to be studied are O3, sulfuric acid (H2SO4) and nitric acid (HNO3)...