Genomes and Genes
Summary: Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
Publications354 found, 100 shown here
- Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?Richard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
Endocr Rev 30:96-116. 2009..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
- Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesityGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Am J Clin Nutr 79:537-43. 2004..Thus, the increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of HFCS in calorically sweetened beverages may play a role in the epidemic of obesity...
- Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular diseaseRichard J Johnson
Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Clin Nutr 86:899-906. 2007..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis...
- Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the communityRavi Dhingra
Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
Circulation 116:480-8. 2007..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
- Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysisJohn L Sievenpiper
Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 156:291-304. 2012..The contribution of fructose consumption in Western diets to overweight and obesity in populations remains uncertain...
- T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1Robert F Margolskee
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 104:15075-80. 2007....
- Fructose and non-fructose sugar intakes in the US population and their associations with indicators of metabolic syndromeSam Z Sun
Office of Compliance and Ethics, Archer Daniels Midland Company, 1001 North Brush College Road, Decatur, IL 62521, USA
Food Chem Toxicol 49:2875-82. 2011..Relationships of sugar intakes with indicators of metabolic syndrome are important concerns for public health and safety. For individuals, dietary intake data for fructose and other sugars are limited...
- Fructose: metabolic, hedonic, and societal parallels with ethanolRobert H Lustig
Division of Endocrinology, University of California, San Francisco, CA 94143 0434, USA
J Am Diet Assoc 110:1307-21. 2010..On a societal level, the treatment of fructose as a commodity exhibits market similarities to ethanol. Analogous to ethanol, societal efforts to reduce fructose consumption will likely be necessary to combat the obesity epidemic...
- Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazardGeorge A Bray
Pennington Biomedical Research Centre, Louisiana State University, Baton Rouge, Louisiana 70808, USA
J Diabetes Sci Technol 4:1003-7. 2010..Some claim that sugar is natural, but natural does not assure safety...
- Consuming fructose-sweetened beverages increases body adiposity in miceHella Jürgens
Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Obes Res 13:1146-56. 2005....
- Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2Oliver J Mace
Department of Biology Area 3, University of York, York YO10 5YW, UK
J Physiol 582:379-92. 2007....
- A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humansKim Anne Le
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 84:1374-9. 2006..In rodents, fructose leads to insulin resistance and ectopic lipid deposition. In humans, the effects of fructose on insulin sensitivity remain debated, whereas its effect on ectopic lipids has never been investigated...
- Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjectsJing Ma
University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, North Terr, Adelaide SA 5000, Australia
Am J Physiol Gastrointest Liver Physiol 296:G735-9. 2009..4 mM (73.7+/-3.1 min) or 4 mM (76.7+/-3.1 min) and saline. We conclude that sucralose, delivered by intragastric infusion, does not stimulate insulin, GLP-1, or GIP release or slow gastric emptying in healthy humans...
- Sucrose activates human taste pathways differently from artificial sweetenerGuido K W Frank
University of Colorado at Denver and Health Sciences Center, Department of Psychiatry, The Children s Hospital, Aurora, CO 80045, USA
Neuroimage 39:1559-69. 2008..This could have important implications on how effective artificial sweeteners are in their ability to substitute sugar intake...
- Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight womenKathleen J Melanson
Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, Rhode Island, USA
Nutrition 23:103-12. 2007..This study examined effects of beverages sweetened with HFCS or sucrose (Suc), when consumed with mixed meals, on blood glucose, insulin, leptin, ghrelin, and appetite...
- Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescentsStephanie Nguyen
Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
J Pediatr 154:807-13. 2009..To evaluate whether sugar-sweetened beverage consumption, a significant source of dietary fructose, is associated with higher serum uric acid levels and blood pressure in adolescents...
- Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and womenC L Cox
Department of Nutrition, University of California, Davis, Davis, CA, USA
Eur J Clin Nutr 66:201-8. 2012....
- Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feedingAlexandra Shapiro
Dept of Pharmacology and Therapeutics, Box 100267, Univ of Florida, Gainesville, Florida 32610, USA
Am J Physiol Regul Integr Comp Physiol 295:R1370-5. 2008..Our data indicate that chronic fructose consumption induces leptin resistance prior to body weight, adiposity, serum leptin, insulin, or glucose increases, and this fructose-induced leptin resistance accelerates high-fat induced obesity...
- Food reward in the absence of taste receptor signalingIvan E de Araujo
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:930-41. 2008..Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction...
- Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male ratsMohamed B Abou-Donia
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27708, USA
J Toxicol Environ Health A 71:1415-29. 2008....
- Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretionRebecca J Brown
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Diabetes Care 32:2184-6. 2009..The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans...
- Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gainSharon P Fowler
Department of Medicine, Division of Clinical Epidemiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Obesity (Silver Spring) 16:1894-900. 2008..069), were significant in all 13 remaining strata. These findings raise the question whether AS use might be fueling--rather than fighting--our escalating obesity epidemic...
- Straight talk about high-fructose corn syrup: what it is and what it ain'tJohn S White
White Technical Research, Argenta, IL 62501, USA
Am J Clin Nutr 88:1716S-1721S. 2008..I conclude that the HFCS-obesity hypothesis is supported neither in the United States nor worldwide...
- Nutritively sweetened beverage consumption and body weight: a systematic review and meta-analysis of randomized experimentsR D Mattes
Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
Obes Rev 12:346-65. 2011..We recommend an adequately powered RCT with overweight persons, for whom there is suggestive evidence of an effect...
- Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanismsRichard D Mattes
Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 89:1-14. 2009..Most of the purported mechanisms by which this occurs are not supported by the available evidence, although some warrant further consideration. Resolution of this important issue will require long-term randomized controlled trials...
- Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivoYukihiro Fujita
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Am J Physiol Endocrinol Metab 296:E473-9. 2009..Collectively, our findings do not support the concept that release of incretins from enteroendocrine cells is triggered by carbohydrates via a pathway identical to the sensation of "sweet taste" in the tongue...
- How bad is fructose?George A Bray
Am J Clin Nutr 86:895-6. 2007
- Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangementsSusan E Swithers
Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
Trends Endocrinol Metab 24:431-41. 2013..Because of this interference, frequent consumption of high-intensity sweeteners may have the counterintuitive effect of inducing metabolic derangements. ..
- Impairment of long-term associative memory in aging snails (Lymnaea stagnalis)Petra M Hermann
Department of Biological Sciences, Faculty of Science, University of Calgary, Alberta, Canada
Behav Neurosci 121:1400-14. 2007..Together, these results present the Lymnaea feeding system as a powerful paradigm for investigations of cellular and molecular foundations of biological aging in the brain...
- Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know?James M Rippe
University of Central Florida Medical School, Orlando, FL and Rippe Lifestyle Institute, Shrewsbury, MA, USA
Adv Nutr 4:236-45. 2013..The purpose of this review is to summarize current knowledge about the metabolism, endocrine responses, and potential health effects of sucrose, HFCS, and fructose...
- Mammalian sweet taste receptorsG Nelson
Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
Cell 106:381-90. 2001..Finally, we present a detailed analysis of the patterns of expression of T1Rs and T2Rs, thus providing a view of the representation of sweet and bitter taste at the periphery...
- Fructose toxicity: is the science ready for public health actions?Luc Tappy
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 15:357-61. 2012..This review evaluates the scientific basis for such action...
- Effects of carbohydrates on satiety: differences between liquid and solid foodAn Pan
Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Curr Opin Clin Nutr Metab Care 14:385-90. 2011..To examine the satiety effect of carbohydrates with a focus on the comparison of liquid and solid food and their implications for energy balance and weight management...
- Mechanisms for sweetnessJohn D Fernstrom
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Nutr 142:1134S-41S. 2012..In addition, information relating to low-calorie sweeteners (LCS) is discussed in the context of these issues. Particular consideration is given to the known effects of LCS on enteroendocrine cell function...
- Synthesis and sensory evaluation of ent-kaurane diterpene glycosidesIndra Prakash
Organic Chemistry Department, Global Research and Development, The Coca Cola Company, One Coca Cola Plaza, Atlanta, GA 30313, USA
Molecules 17:8908-16. 2012..Also, we report herewith the sensory evaluation of all the reduced compounds against their corresponding original steviol glycosides and sucrose for the sweetness property of these molecules...
- Amygdala response to sucrose consumption is inversely related to artificial sweetener useK J Rudenga
Interdepartmental Neuroscience Program, Yale University, SHM L 200, New Haven, CT 06520, USA
Appetite 58:504-7. 2012..This finding supports the hypothesis that artificial sweetener use may be associated with brain changes that could influence eating behavior...
- The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parametersJoshua Lowndes
Rippe Lifestyle Institute, 215 Celebration Place, Celebration, FL 34747, USA
Nutr J 11:55. 2012..The objective of this study was to examine the effects of four equally hypocaloric diets containing different levels of sucrose or high fructose corn syrup (HFCS)...
- Altered processing of sweet taste in the brain of diet soda drinkersErin Green
San Diego State University University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
Physiol Behav 107:560-7. 2012..These findings may provide some insight into the link between diet soda consumption and obesity...
- Non-nutritive sweeteners, energy balance, and glucose homeostasisMarta Y Pepino
School of Medicine, Washington University in St Louis, St Louis, Missouri 63110, USA
Curr Opin Clin Nutr Metab Care 14:391-5. 2011..To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain...
- Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressureIan J Brown
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
Hypertension 57:695-701. 2011..These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced...
- Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in womenAndrew W Brown
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
Nutr Res 31:882-8. 2011..Therefore, sucralose may be a relatively inert nonnutritive sweetener with regard to hunger signaling and short-term glucose homeostasis...
- Rationale for further medical and health research on high-potency sweetenersSusan S Schiffman
Schiffman Consulting, 18 Heath Place, Durham, NC 27705 5713, USA
Chem Senses 37:671-9. 2012..Nine research needs are described that address some of the major unknown issues associated with ingestion of high-potency sweeteners...
- Sucralose - an ecotoxicological challenger?Ann Kristin Eriksson Wiklund
Department of Applied Environmental Science ITM Stockholm University, SE 106 91 Stockholm, Sweden
Chemosphere 86:50-5. 2012....
- Artificial sweeteners: a systematic review of metabolic effects in youthRebecca J Brown
National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Int J Pediatr Obes 5:305-12. 2010....
- Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemiaJae Yong Kim
School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Republic of Korea
Food Chem Toxicol 49:2899-905. 2011..Saccharin-fed zebrafish had an increased atherogenic serum lipid profile with elevation of CETP activity...
- Factors associated with sugar-sweetened beverage intake among United States high school studentsSohyun Park
Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Nutr 142:306-12. 2012..Our findings of significant associations of high SSB intake with frequent fast-food restaurant use and sedentary behaviors may be used to tailor intervention efforts to reduce SSB intake among high-risk populations...
- Intense sweeteners, energy intake and the control of body weightF Bellisle
France Bellisle, INRA, CRNH Ile de France, Paris XIII Leonard de Vinci, Bobigny, France
Eur J Clin Nutr 61:691-700. 2007....
- Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjectsJing Ma
Discipline of Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
Br J Nutr 104:803-6. 2010..In conclusion, sucralose does not appear to modify the rate of glucose absorption or the glycaemic or incretin response to ID glucose infusion when given acutely in healthy human subjects...
- Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptidesRobert E Steinert
Division of Gastroenterology, Department of Biomedicine, Clinical Research Center, University Hospital Basel, Basel, Switzerland
Br J Nutr 105:1320-8. 2011..Our data demonstrate that the secretion of GLP-1, PYY and ghrelin depends on more than the detection of (1) sweetness or (2) the structural analogy to glucose...
- Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjectsH E Ford
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK
Eur J Clin Nutr 65:508-13. 2011..We conducted a randomised, single-blinded, crossover study in eight healthy subjects to investigate whether oral ingestion of sucralose could stimulate L-cell-derived GLP-1 and peptide YY (PYY) release in vivo...
- Drinking caloric beverages increases the risk of adverse cardiometabolic outcomes in the Coronary Artery Risk Development in Young Adults (CARDIA) StudyKiyah J Duffey
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27516 3997, USA
Am J Clin Nutr 92:954-9. 2010..Intake of caloric beverages is hypothesized to contribute to adverse health outcomes, but the beverages and populations studied vary considerably...
- Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidenceFrank B Hu
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Physiol Behav 100:47-54. 2010..Consumption of SSBs should therefore be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases...
- High-intensity sweeteners and energy balanceSusan E Swithers
Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, United States
Physiol Behav 100:55-62. 2010....
- Molecular mechanism of the sweet taste enhancersFeng Zhang
Senomyx, Inc, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 107:4752-7. 2010..Whereas the sweeteners bind to the hinge region and induce the closure of the Venus flytrap domain of T1R2, the enhancers bind close to the opening and further stabilize the closed and active conformation of the receptor...
- Appetite regulation and energy balanceCharlotte Erlanson-Albertsson
Department of Experimental Medicine, University of Lund, Lund, Sweden
Acta Paediatr Suppl 94:40-1. 2005..The palatable food works by weakening the satiety signals and activating the hunger signals. The reward system with endogenous opiates may also be activated...
- Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by childrenAnne Maguire
School of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK
Int J Paediatr Dent 17:231-8. 2007..The aim of this study was to assess the erosive potential of 97 paediatric medicines in vitro...
- Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeksChad L Cox
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Clin Endocrinol Metab 96:E2034-8. 2011..Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable...
- Stevioside and related compounds: therapeutic benefits beyond sweetnessVaranuj Chatsudthipong
Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
Pharmacol Ther 121:41-54. 2009..Although much progress has been made concerning their biological and pharmacological effects, questions regarding chemical purity and safety remain unsolved. These issues are discussed to help guide future research directions...
- Role of dopamine D1 and D2 receptors in the nucleus accumbens shell on the acquisition and expression of fructose-conditioned flavor-flavor preferences in ratsSonia Y Bernal
Neuropsychology Doctoral Subprogram, Graduate Center, City University of New York, New York, NY, USA
Behav Brain Res 190:59-66. 2008..These data indicate that NAcS D1 and D2 antagonists significantly attenuated the expression of the fructose-CFP and did not block acquisition, but hastened extinction of fructose-CFP...
- A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomesNatasha Wiebe
Department of Medicine, 13 103 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada
BMC Med 9:123. 2011..The major metabolic complications of obesity and type 2 diabetes may be prevented and managed with dietary modification. The use of sweeteners that provide little or no calories may help to achieve this objective...
- Non-caloric sweeteners, sweetness modulators, and sweetener enhancersGrant E DuBois
The Coca Cola Company, Atlanta, Georgia 30313, USA
Annu Rev Food Sci Technol 3:353-80. 2012..Research on PAM discovery over the past decade is summarized...
- Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer diseaseDongfeng Cao
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 282:36275-82. 2007..These data underscore the potential role of dietary sugar in the pathogenesis of AD and suggest that controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD...
- Variability in clinical practice guidelines for sweetening agents in newborn infants undergoing painful proceduresAnna Taddio
Department of Pharmacy Practice, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Clin J Pain 25:153-5. 2009b>Sweetening agents have been recommended in position statements and consensus documents for procedural pain management in neonates; however, it is not clear if this has resulted in widespread adoption in clinical practice...
- Sweetness, satiation, and satietyFrance Bellisle
Centre de Recherche en Nutrition Humaine d Ile de France, Universite Paris, Bobigny, France
J Nutr 142:1149S-54S. 2012..The brain mechanisms of food reward (in terms of "liking" and "wanting") are also addressed. Finally, we highlight the importance of reward homeostasis, which can help prevent eating in the absence of hunger, for the control of intake...
- NMR studies of the conformation of the natural sweetener rebaudioside AWayne E Steinmetz
Chemistry Department, Pomona College, Claremont, CA 91711, United States
Carbohydr Res 344:2533-8. 2009..Hydrogen bonding was examined using the temperature coefficients of the hydroxyl chemical shifts, ROESY and long-range COSY spectra, and proton-proton coupling constants...
- Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant womenThorhallur I Halldorsson
Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark
Am J Clin Nutr 92:626-33. 2010..However, the safety of artificial sweeteners has been disputed, and consequences of high intakes of artificial sweeteners for pregnant women have been minimally addressed...
- Synthesis of ent-kaurane diterpene monoglycosidesVenkata Sai Prakash Chaturvedula
Organic Chemistry Department, Global Research and Development, The Coca Cola Company, One Coca Cola Plaza, Atlanta, GA 30313, USA
Molecules 16:8402-9. 2011..Synthesis of all three steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR as well as mass spectral (MS) data...
- Impact of change in sweetened caloric beverage consumption on energy intake among children and adolescentsY Claire Wang
Department of Health Policy and Management, Columbia Mailman School of Public Health, 600 W 168th Street, New York, NY 10032, USA
Arch Pediatr Adolesc Med 163:336-43. 2009..To estimate the net caloric impact from replacing sugar-sweetened beverages (SSBs) with alternatives in children and adolescents in naturalistic settings...
- Sweet taste signaling in the gutAnthony Sclafani
Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
Proc Natl Acad Sci U S A 104:14887-8. 2007
- Saccharin as a sugar surrogate revisitedJames C Smith
Department of Psychology, The Florida State University, Tallahassee, FL 32306 1270, USA
Appetite 38:155-60. 2002..4% (19.5 mM). Furthermore, saccharin versus sucrose choice tests indicate that optimal saccharin solutions (0.2-0.4%) are "isopreferred" to only dilute sucrose solutions (2-4%). Thus, at best, saccharin is only a weak surrogate for sugar...
- The receptor basis of sweet taste in mammalsS Vigues
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Results Probl Cell Differ 47:187-202. 2009..In this chapter, we discuss some of the mechanisms underlying the detection of sweeteners by mammals, with a particular focus on the function and role of the T1R2:T1R3 receptor in these processes...
- Sugar sweetened beverage consumption by Australian children: implications for public health strategyKatherine Hafekost
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA 6872, Australia
BMC Public Health 11:950. 2011..We sought to address this using a contemporary Australian dataset to examine purchase source, consumption pattern, dietary factors, and demographic profile of SSB consumption in children...
- Molecular mechanism of species-dependent sweet taste toward artificial sweetenersBo Liu
Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 31:11070-6. 2011..Our studies not only shed light on the molecular mechanism of species-dependent sweet taste toward artificial sweeteners, but also provide guidance for designing novel effective artificial sweet compounds...
- The type of caloric sweetener added to water influences weight gain, fat mass, and reproduction in growing Sprague-Dawley female ratsHeather R Light
Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506, USA
Exp Biol Med (Maywood) 234:651-61. 2009..Based on this study, the type of caloric sweetener added to beverages should be considered when making dietary recommendation for reducing excess body weight and related health risk...
- SuperSweet--a resource on natural and artificial sweetening agentsJessica Ahmed
Charite Universitatsmedizin Berlin, Institute of Physiology, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany
Nucleic Acids Res 39:D377-82. 2011..A sweetener classification tree and browsing features allow quick requests to be made to the database. The database is freely available at: http://bioinformatics.charite.de/sweet/...
- Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptorPiero Andrea Temussi
Computational Biology Unit, EMBL, Heidelberg, Germany
FEBS Lett 526:1-4. 2002..Docking of brazzein, monellin and thaumatin with a model of the T1R2-T1R3 sweet taste receptor shows that the most likely complexes can indeed stabilize the active form of the receptor...
- Replacing sweetened caloric beverages with drinking water is associated with lower energy intakeJodi D Stookey
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Obesity (Silver Spring) 15:3013-22. 2007..Compensatory increases in other food or beverages reportedly negate benefits of diet beverages. The purpose of this study was to evaluate drinking water as an alternative to SCBs...
- Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetesV Lee Grotz
Medical and Nutritional Affairs, McNeil Nutritionals, New Bruswick, NJ 08903 2400, USA
J Am Diet Assoc 103:1607-12. 2003..To investigate the effect of 3-months' daily administration of high doses of sucralose, a non-nutritive sweetener, on glycemic control in subjects with type 2 diabetes...
- Positive allosteric modulators of the human sweet taste receptor enhance sweet tasteGuy Servant
Senomyx, Inc, La Jolla, CA 92121, USA
Proc Natl Acad Sci U S A 107:4746-51. 2010..These enhancers did not exhibit any sweetness when tasted on their own. Positive allosteric modulators of the human sweet taste receptor could help reduce the caloric content in food and beverages while maintaining the desired taste...
- Sweetness intensity and pleasantness in children, adolescents, and adultsC de Graaf
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, The Netherlands
Physiol Behav 67:513-20. 1999..The age effects were similar for sucrose in water and sucrose in lemonade...
- Sugar-sweetened and artificially sweetened soft drinks in association to restrained, external and emotional eatingK Elfhag
Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institutet, Sweden
Physiol Behav 91:191-5. 2007..Light soft drinks may be perceived as an adequate substitute in the use of foods for comfort, meaning the sweet taste may be sufficient for this purpose...
- Isomaltulose (Palatinose): a review of biological and toxicological studiesB A R Lina
TNO Nutrition and Food Research, Zeist, The Netherlands
Food Chem Toxicol 40:1375-81. 2002..On the basis of the data reviewed it is concluded that the use of isomaltulose as an alternative sugar is as safe as the use of other digestible sugars consisting of glucose and fructose...
- Formaldehyde, aspartame, and migraines: a possible connectionSharon E Jacob
Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA
Dermatitis 19:E10-1. 2008..We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing...
- Obesity by choice revisited: effects of food availability, flavor variety and nutrient composition on energy intakeKaren Ackroff
Brooklyn College and the Graduate School of the City University of New York, Brooklyn, NY 11210, USA
Physiol Behav 92:468-78. 2007..The nature of optional foods (nutrient composition and physical form) was markedly more important than the number of food sources available to the animals, and is a better contender as the reason for "obesity by choice"...
- Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domainAyako Koizumi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo, Japan
Biochem Biophys Res Commun 358:585-9. 2007..Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study is apparently the first to identify the ATD of hT1R3 as a new sweetener-binding region...
- The effect of frequency of consumption of artificial sweeteners on sweetness liking by womenA Mahar
School of Nutrition and Dietetics, 12 University Ave, Acadia Univ, Wolfville, Nova Scotia, Canada
J Food Sci 72:S714-8. 2007..Categorization by sweetener type resulted in no significant differences between the groups, indicating that regardless of the type of sweetener consumed in a beverage, liking of sweetness will be influenced in the same manner...
- The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidenceC Hayes
Harvard School of Dental Medicine, Boston, MA, USA
J Dent Educ 65:1106-9. 2001..The highest caries reductions were observed in subjects using xylitol. These findings suggest that the replacement of sucrose with sorbitol and xylitol may significantly decrease the incidence of dental caries...
- Consumption of caloric and non-caloric versions of a soft drink differentially affects brain activation during tastingPaul A M Smeets
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Neuroimage 54:1367-74. 2011..In addition, implications for the effectiveness of non-caloric sweeteners in decreasing energy intake need to be established...
- Oral glucose as an analgesic to reduce infant distress following immunization at the age of 3, 5 and 12 monthsMargit Thyr
Department of Children s Health, Bollnäs Health Centre, Bollnäs, Sweden
Acta Paediatr 96:233-6. 2007..To evaluate oral glucose as an analgesic to reduce infant distress after immunization during the first year of life and to investigate if these effects change during this period...
- Female rats show a bimodal preference response to the artificial sweetener sucraloseAnthony Sclafani
Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Ave, Brooklyn, NY 11210, USA
Chem Senses 29:523-8. 2004..Both subgroups preferred saccharin to sucralose. Sucralose appears to have an aversive off-taste that reduces its palatability to rats...
- Consumer acceptability of low-sugar watermelon sweetened with non-calorie sweetener by a Native American communityJulie K Collins
USDA ARS, South Central Agricultural Research Laboratory, Lane, Oklahoma, USA
Int J Food Sci Nutr 57:363-8. 2006..The low-sugar watermelons were lower in sugar composition but were comparable with conventional melons in all other quality factors and were found acceptable in taste by a broad age group of Native American consumers...
- Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark, 2005T Leth
National Food Institute, DTU, Søborg, Denmark
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:662-8. 2008..The reduction in the European Union of the maximum permitted level for cyclamate from 400 to 250 mg l(-1) has brought the intake of cyclamate in small children down to well below the acceptable daily intake value...
- Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intakeNancy K Dess
Department of Psychology, Occidental College, 1600 Campus Road, Los Angeles, CA 90041, USA
Chem Senses 34:211-20. 2009..Implications for the study of variation in sweet taste are discussed...
- Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessmentT Husøy
Department of Food Safety and Nutrition, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
Food Chem Toxicol 46:3099-105. 2008..The highest intake of benzoic acid was observed for 1- to 2-year-old children, and benzoic acid intake in Norwegian children is therefore considered to be of special concern...
- Responses to basic taste qualities in rats selectively bred for high versus low saccharin intakeN K Dess
Occidental College, 1600 Campus Rd, 90041, Los Angeles, CA, USA
Physiol Behav 69:247-57. 2000..Additional work can clarify the psychobiological mechanisms for the phenotypic difference and, potentially, the reasons for its relationship to measures of emotionality...
- Artificial sweetener use among children: epidemiology, recommendations, metabolic outcomes, and future directionsAllison Sylvetsky
Graduate Division of Biological and Biomedical Sciences, Emory University, 1462 Clifton Road, Suite 314, Atlanta, GA 30322, USA
Pediatr Clin North Am 58:1467-80, xi. 2011....
- Rebaudioside A: two-generation reproductive toxicity study in ratsLeslie L Curry
Cargill, Incorporated, 15407 McGinty Road W MS 163, Wayzata, MN 55391, United States
Food Chem Toxicol 46:S21-30. 2008..The NOAEL for reproductive effects was 25,000ppm and the NOAEL for the survival, development, and general condition of the offspring also was considered to be 25,000ppm or 2048-2273mg/kg body weight/day...
- Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteinsAnthony Sclafani
Dept of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
Am J Physiol Regul Integr Comp Physiol 293:R1504-13. 2007..The experience-induced rescue of fat and Polycose preferences in the KO mice likely reflects the action of a postoral-conditioning mechanism, which functions in the absence of alpha-gustducin and Trpm5...
- Ingestional responses to metabolic challenges in rats selectively bred for high and low saccharin intakeDennis A VanderWeele
Department of Psychology, Occidental College, 1600 Campus Road, Los Angeles, CA 90041, USA
Physiol Behav 75:97-104. 2002....
- Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitusK C Maki
Provident Clinical Research, 1000 West 1st Street, Bloomington, IN, United States
Food Chem Toxicol 46:S47-53. 2008..placebo. These results suggest that chronic use of 1000mg rebaudioside A does not alter glucose homeostasis or blood pressure in individuals with type 2 diabetes mellitus...
- Nutrient selection in the absence of taste receptor signalingXueying Ren
The John B Pierce Laboratory, New Haven, Connecticut 06519, USA
J Neurosci 30:8012-23. 2010....
- Mechanisms of glucosensation mediating food choice behavior in DrosophilaMonica Dus; Fiscal Year: 2013..They will also provide mammalian researchers with conserved genes to use as molecular and neurochemical markers in future studies of glucosensation, feeding, and disease. ..
- Modulation of Taste-Related Behavior by Molecular Mediators of Appetite &SatietyCedrick D Dotson; Fiscal Year: 2013..Using a combination of genetic and pharmacological models, the proposed studies focus on investigating the general hypothesis that taste-related behavior can be modulated by metabolic hormones such as PYY and/or NPY. ..
- Sweet taste receptors and glucose metabolism in healthy and T2DM humansKaren L Teff; Fiscal Year: 2012..Our overall hypothesis is that in healthy subjects, the STR receptor is involved in the regulation of post-prandial glucose metabolism and GLP levels but in T2DM, the STR receptor is unresponsive to activation or inhibition ..
- Neuropeptide Modulation of Taste SignalsNirupa Chaudhari; Fiscal Year: 2010..This understanding would suggest new pharmacological possibilities to address eating disorders. ..
- Role of taste signaling elements in enteroendocrine cellsRobert F Margolskee; Fiscal Year: 2013..The experiments proposed to functionally characterize the roles of gustducin and other taste signaling elements in enteroendocrine cells have medical relevance to appetite, satiety, diabetes and obesity. ..
- The Role of RGS Proteins in the Regulation of Taste TransductionStaci P Cohen; Fiscal Year: 2013..Our results will help define the role of RGS proteins in shaping the duration and potency of tastant signaling. ..
- Comparative Genetics of Sweet Taste in CarnivoraPeihua Jiang; Fiscal Year: 2013....
- Agonist & Antagonist Activity and Binding on the TMD of hT1R3Marianna Max; Fiscal Year: 2010..Understanding the sweet receptor at a molecular level will enable the design of better low calorie sweeteners. ..
- Development of Age-Appropriate Fast Disintegrating Pediatric Granules and TabletsMOJI ADEYEYE; Fiscal Year: 2009....
- Functional characterization of endocrine taste cellsRobert F Margolskee; Fiscal Year: 2013..The experiments proposed to identify and functionally characterize these lingual endocrine cells have medical relevance to appetite, satiety, diabetes and obesity. ..
- Yale Tobacco Center of Regulatory ScienceSTEPHANIE S O'MALLEY; Fiscal Year: 2013..This comprehensive effort will help the FDA develop science based policies to reduce addiction to tobacco products. ..
- 2011 Symposium on Flavors and FeedingRichard D Mattes; Fiscal Year: 2011..The proceedings will be published and should aid basic and applied research and policy decisions related to obesity management. ..
- Analysis of sweet receptor ligand binding and activationMarianna Max; Fiscal Year: 2010..The studies in this proposal will enhance our understanding at the molecular level of sweet receptor function with the hope of future means to control our sweet cravings and the attendant diseases of over-consumption. ..
- The role of sweet taste genes in postingestive endocrine responses to sweetenersAlexander A Bachmanov; Fiscal Year: 2013..Zolotarev as an extension of NIH grant R01DC000882 (09/19/2008 - 08/31/2013). PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page ..
- The sweet protein brazzein and its interaction with the human taste receptorFariba M Assadi-Porter; Fiscal Year: 2012..Explanation of molecular features that are essential for the brazzein-sweet receptor interaction may result in design of superior tasting non-caloric sweetener as an approach to help addressing diabetes and related disorders. ..
- Integration of retronasal olfaction and taste: Volatile-enhanced SweetnessLINDA MAY BARTOSHUK; Fiscal Year: 2013..g., women and men). ..
- Corticostriatal Processing of Taste, Motivation and Self-Control of Food IntakeMark Laubach; Fiscal Year: 2013..We will combine methods for reversible inactivation and optogenetic perturbation in the cortex with multi-electrode recordings in the striatum. ..
- Identification of anti-cariogenic/low-glycemic activity factors from Lo Han KuoCHIFU HUANG; Fiscal Year: 2006..Thus, there appears to remain a viable market for the identification of novel sweetening agents that can be: (1) used by the general population; (2) demonstrate a anti-cariogenic capacity; (3) have a low ..
- Transmission of Taste Signals in Taste BudsThomas E Finger; Fiscal Year: 2010..Taken together, the proposed studies will test the role of ATP and ionotropic purinergic receptors in transmission of taste information. ..
- NONCARIOGENIC INTENSE NATURAL SWEETNERSALAN KINGHORN; Fiscal Year: 1993..objective of this investigation, therefore, is to isolate novel potentially noncariogenic natural intense sweetening agents from several plant species already identified as being sweet, as well as from other sweet plants that will ..
- Modeling Sweet Protein-Receptor InteractionsMeng Cui; Fiscal Year: 2010..Replacing sugar with low-or non-caloric sweeteners may be of benefit. To design moreeffective sweeteners it is important to understand at the molecularlevel how the sweet taste receptor functions. ..
- The Role of the TM of T1R2 in Sweet Receptor ActivationMarianna Max; Fiscal Year: 2009....
- Experience induced changes in taste sensitivities for sweeteners and monosodium gLINDA KENNEDY; Fiscal Year: 2009....
- NOVEL PEPTIDE DERIVED SWEETENERSMurray Goodman; Fiscal Year: 1993..Additional target molecules incorporate 1- aminocycloalkane carboxylic acid residues. In this manner, we hope to develop a precise understanding of structure-taste relationships and to design novel, safe and stable tastants...
- UNDERSTANDING & DEVELOPING ASYMMETRIC CATALYSISCLARK LANDIS; Fiscal Year: 1992..Catalytic amination chemistry will be explored through fundamental investigations of N-H bond activation at electron-rich metal complexes such as phosphine- ligated, zerovalent group 8 complexes...
- 3-D STRUCTURES OF TWO LOW-CALORIE PROTEIN SWEETENERSJoachim Weickmann; Fiscal Year: 1992..The combination of structural information with receptor binding studies and quantitative primate taste tests should allow us to design a second generation of protein sweeteners with specific taste and stability characteristics...
- Mechanism of Agonism-Antagonism of Sweet Taste ReceptorsMeng Cui; Fiscal Year: 2007..Understanding the taste response mechanisms may also be important for developing new treatment methods for patients with taste malfunctions. [unreadable] [unreadable]..
- Molecular Mechanisms of Sweet Receptor FunctionMarianna Max; Fiscal Year: 2009..abstract_text> ..
- PHYSIOLOGY OF THE SWEET TASTE RESPONSEWILLIAM JAKINOVICH; Fiscal Year: 1990..Finally, in a further attempt to elucidate the number of receptor sites, experiments using single neurons will be conducted...
- Neuropharmacology of Learned Food PreferencesAnthony Sclafani; Fiscal Year: 2009..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMCEDRICK DOTSON; Fiscal Year: 2005..As such these behavioral experiments will provide a functional context to guide the interpretation of findings from more molecular levels of analysis. ..
- ALCOHOL APPETITE--A NUTRIENT CONDITIONING ANALYSISKaren Ackroff; Fiscal Year: 2001..It will advance our basic knowledge of the psychobiology of alcohol appetite and may provide practical benefits for controlling alcohol consumption in humans. ..
- Lactisole inhibits the sweet taste receptorPeihua Jiang; Fiscal Year: 2004..Knowledge of the structure/function relationship of T1R3 may assist in the development of novel, low caloric sweeteners to help fight against diet-related disorders such as obesity and diabetes. ..
- DIETARY OBESITYGeorge Bray; Fiscal Year: 2007..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
- GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICEAlexander Bachmanov; Fiscal Year: 2007..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
- DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUSPatricia Sue Grigson; Fiscal Year: 2010..e., cocaine and heroin);and (c) Reveal that the nucleus accumbens depends upon an intact thalamocoritical loop to track cocaine's devaluation of a sweet. ..
- Uric Acid and Hypertension in African-AmericansMark Segal; Fiscal Year: 2008..In Aim 3 we test the hypothesis that prevention of chlorthalidone induced hyperuricemia with allopurinol improves renal blood flow and GFR and prevents microalbumineria. [unreadable] [unreadable]..
- HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITYJOHN GLENDINNING; Fiscal Year: 2001..A normative data-base for both screens will be established and made available to the scientific community. The assay procedures developed will be applicable by a single laboratory technician with limited experience. ..
- BEYOND RACE--EXPLAINING INEQUALITY MANIFESTED AS OBESITYBarry Popkin; Fiscal Year: 2003..This work will provide important insights in the relative importance of genetic and environmental determinants of overweight and activity. ..
- GUSTATORY REWARD AND DOPAMINE IN THE NUCLEUS ACCUMBENSAndras Hajnal; Fiscal Year: 2003..This knowledge is directly relevant to understanding the control of normal ingestive behavior and to the maladies related to this essential behavior, such as obesity, anorexia nervosa, bulimia nervosa, and binge eating disorder. ..
- XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXISLouis Vernacchio; Fiscal Year: 2003..A preliminary estimate of the effect size of xylitol treatment from the pilot RCT will suggest whether the effect if sufficiently large to warrant a large formal RCT to be proposed. ..
- Vulnerability to Drug Abuse and Treatment Efficacy: Animal ModelsMarilyn E Carroll; Fiscal Year: 2010..The proposed research will show how enhanced drug-seeking behavior in vulnerable phenotypes can be reduced at the most critical, vulnerable phases of drug abuse through behavioral and pharmacological interventions. ..
- Dopamine mechanisms in development of type-2 diabetesAndras Hajnal; Fiscal Year: 2008..These studies will help determine how plasticity in the dopaminergic system affects behavioral and metabolic factors related to hyperphagia and the development of dietary-induced NIDDM. ..
- An Interdisciplinary Strategy for Obesity (RMI)Barry Popkin; Fiscal Year: 2006..We will apply the knowledge gained from our interdisciplinary research to achieve our long-term goal of developing novel treatment and prevention interventions for obesity. [unreadable] [unreadable]..
- Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization ProgramPeter Milgrom; Fiscal Year: 2008..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
- Young Adult Environmental and Physical Activity DynamicsBarry Popkin; Fiscal Year: 2008..No study heretofore has had large-scale groupings and in-depth environmental measures over time to examine these issues in a dynamic manner. ..
- Rapid DA-Acb signaling in ingestive behaviorsMITCHELL ROITMAN; Fiscal Year: 2008..These studies will establish the range of natural stimuli that promote rapid DA-Acb signaling - setting the foundation for examining aberrant signaling underlying drug addiction. [unreadable] [unreadable] [unreadable] [unreadable]..
- Biotech & Materials Research to Reduce Caries DisparityPeter Milgrom; Fiscal Year: 2005..The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project. ..
- Diet, Activity, Obesity & The Built Environment DynamicsBarry Popkin; Fiscal Year: 2009..A central issue is determining modifiable environment factors that may reduce ethnic and socioeconomic differentials in health status. ..
- Physical Environment Dynamics, Inequality and ObesityBarry Popkin; Fiscal Year: 2006..We will also consider issues related to sample selectivity, within race heterogeneity and acculturation. ..
- Planning Grant for Xylitol Trial in Caries-Active AdultsJames Bader; Fiscal Year: 2005....
- CENTRAL GUSTATORY ELECTROPHYSIOLOGY IN MICEStuart McCaughey; Fiscal Year: 2005..abstract_text> ..
- PERIPHERAL GUSTATORY PROCESSINGMARION ELIZABETH FRANK; Fiscal Year: 2010..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
- CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGEBarry Popkin; Fiscal Year: 2004..Finally, we will compare results across countries to determine whether there is a consistent pattern or structure of relationships across countries at different levels of development. ..
- Human Salty and Bitter Taste MechanismsMARION FRANK; Fiscal Year: 2007..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..