neuroprotective agents

Summary

Summary: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

Top Publications

  1. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
  2. ncbi Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
  3. ncbi ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
    Pamela Maher
    Department of Cellular Neurobiology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Hum Mol Genet 20:261-70. 2011
  4. ncbi Neuroprotection for ischemic stroke: past, present and future
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuropharmacology 55:363-89. 2008
  5. ncbi Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    T Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
    J Neurosci 21:2580-8. 2001
  6. ncbi Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    J G Nutt
    Oregon Health and Science University, Portland 97201 3098, USA
    Neurology 60:69-73. 2003
  7. ncbi Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?
    Raymond Chuen Chung Chang
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cell Mol Neurobiol 28:643-52. 2008
  8. ncbi 1,026 experimental treatments in acute stroke
    Malcolm R Macleod
    Neuroscience Lab, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Ann Neurol 59:467-77. 2006
  9. ncbi Hydrogen sulfide protects neurons from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    FASEB J 18:1165-7. 2004
  10. ncbi Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    Jeffrey D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nature 433:73-7. 2005

Research Grants

  1. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
  2. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
  3. Molecular Interventions for Bipolar Disorder
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
  4. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2007
  5. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2009
  6. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
  7. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2007
  8. Cerebal Ischemia During Anesthesia and Surgery
    Piyush Patel; Fiscal Year: 2004
  9. Parkinson's Disease Neuroprotection Clinical Center
    Charles Adler; Fiscal Year: 2005
  10. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011

Detail Information

Publications324 found, 100 shown here

  1. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  2. ncbi Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
    ..In addition, we also discuss novel approaches to potential therapeutic strategies...
  3. ncbi ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
    Pamela Maher
    Department of Cellular Neurobiology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Hum Mol Genet 20:261-70. 2011
    ..Thus, fisetin, resveratrol and related compounds might be useful for the treatment of HD by virtue of their unique ability to activate ERK...
  4. ncbi Neuroprotection for ischemic stroke: past, present and future
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuropharmacology 55:363-89. 2008
    ..This review presents a close survey of the most extensively evaluated neuroprotective agents and classes and considers both the strengths and weakness of the pre-clinical evidence as well as the ..
  5. ncbi Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    T Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
    J Neurosci 21:2580-8. 2001
    ..These findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections...
  6. ncbi Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    J G Nutt
    Oregon Health and Science University, Portland 97201 3098, USA
    Neurology 60:69-73. 2003
    ..To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD...
  7. ncbi Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?
    Raymond Chuen Chung Chang
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cell Mol Neurobiol 28:643-52. 2008
    ..barbarum. We hope that new findings for L. barbarum will pave a new avenue for the use of Chinese medicine in modern evidence-based medicine...
  8. ncbi 1,026 experimental treatments in acute stroke
    Malcolm R Macleod
    Neuroscience Lab, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Ann Neurol 59:467-77. 2006
    ..This may partially explain the slow progress in developing treatments. Greater rigor in the conduct, reporting, and analysis of animal data will improve the transition of scientific advances from bench to bedside...
  9. ncbi Hydrogen sulfide protects neurons from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    FASEB J 18:1165-7. 2004
    ..Cystine (cysteine) is the rate-limiting substrate of glutathione synthesis. These observations reveal that H2S protects neurons from oxytosis by increasing the production of the antioxidant glutathione...
  10. ncbi Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    Jeffrey D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nature 433:73-7. 2005
    ..Thus these studies provide a class of potential neurotherapeutics that act to modulate the expression of glutamate neurotransmitter transporters via gene activation...
  11. ncbi Involvement of ROS in BBB dysfunction
    Pamela B L Pun
    Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore
    Free Radic Res 43:348-64. 2009
    ..This review explores some of the pathways both upstream and downstream of ROS that have been implicated in increased BBB permeability and discusses the role of ROS and antioxidants in neuropathology...
  12. ncbi Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Y Du
    Departmens of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 98:14669-74. 2001
    ..Thus, NO appears to play an important role in MPTP neurotoxicity. Neuroprotective tetracyclines may be effective in preventing or slowing the progression of Parkinson's and other neurodegenerative diseases...
  13. ncbi Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
    ..Given r-Hu-EPO's excellent safety profile, clinical trials evaluating systemically administered r-Hu-EPO as a general neuroprotective treatment are warranted...
  14. ncbi Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling
    Xiao Dong Pan
    Department of Neurology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Glia 57:1227-38. 2009
    ..Therefore, T4 may be an effective agent in modulating neuroinflammatory process in AD...
  15. ncbi ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury
    David W Wright
    Department of Emergency Medicine, School of Medicine of Emory University, Atlanta, GA, USA
    Ann Emerg Med 49:391-402, 402.e1-2. 2007
    ..Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury...
  16. ncbi Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma
    Hiu Chi Chan
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Exp Neurol 203:269-73. 2007
    ..barbarum against neurodegeneration in the retina of rat OH model. The results demonstrate that this extract may be a potential candidate for the development of neuroprotective drug against the loss of RGCs in glaucoma...
  17. ncbi The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice
    H Mayumi Homi
    Department of Anesthesiology (Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Anesthesiology 99:876-81. 2003
    ..0009). CONCLUSIONS: In this model of transient focal cerebral ischemia, xenon administration improved both functional and histologic outcome...
  18. ncbi Minocycline delays disease onset and mortality in a transgenic model of ALS
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    Neuroreport 13:1067-70. 2002
    ..These results demonstrate that interference with immuno-inflammatory responses has a beneficial effect in the ALS mice model, suggesting this to be a potential new strategy to treat ALS...
  19. ncbi Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
    Brain Res 1214:177-87. 2008
    ..Taken together, these data further the notion of EGCG dietary supplementation as a potentially safe and effective prophylaxis for Alzheimer's disease...
  20. ncbi Edaravone prevents kainic acid-induced neuronal death
    Ryohei Miyamoto
    Department of Pediatrics, Osaka Medical College, Japan
    Brain Res 1209:85-91. 2008
    ..Patients who develop status epilepticus are unlikely to receive adequate antioxidant therapy before the onset, so it is an advantage that Ed can prevent neuronal death even when administered after seizures...
  21. ncbi Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    M Asahi
    Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Charlestown 02129, USA
    J Cereb Blood Flow Metab 20:1681-9. 2000
    ..These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia...
  22. ncbi Minocycline treatment in acute stroke: an open-label, evaluator-blinded study
    Y Lampl
    Department of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel
    Neurology 69:1404-10. 2007
    ..Ischemic animal model studies have shown a neuroprotective effect of minocycline...
  23. ncbi Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiol
    Joachim G Elzer
    Division of Molecular Biology of the Cell 1, German Cancer Research Center, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:935-42. 2010
    ..We conclude that neuronal ER alpha in female and male mice mediates neuroprotective estrogen effects in an in vivo mouse model of stroke, whereas microglial ER alpha is dispensable...
  24. ncbi Neuroprotection in the newborn infant
    Fernando F Gonzalez
    Department of Pediatrics, University of California, 521 Parnassus Avenue, C215, Box 0663, San Francisco, CA 94143, USA
    Clin Perinatol 36:859-80, vii. 2009
    ..More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells...
  25. ncbi Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
    Chao Liu
    Department of Pharmacology, Pharmaceutical College, Xianning University, Xianning, China
    J Neurochem 112:1500-12. 2010
    ..Together, these findings provide evidence that Bai protects neurons against ischemia injury and this neuroprotective effect involves PI3K/Akt and PTEN pathway...
  26. ncbi Targeting the p53 pathway to protect the neonatal ischemic brain
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Neurol 70:255-64. 2011
    ..To investigate whether inhibition of mitochondrial p53 association using pifithrin-μ (PFT-μ) represents a potential novel neuroprotective strategy to combat perinatal hypoxic-ischemic (HI) brain damage...
  27. ncbi Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research
    Minzhong Ye
    Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, PR China
    J Pharm Pharmacol 61:831-7. 2009
    ..This review summarizes recent research on the neuropharmacological and pharmacokinetic properties of berberine, an isoquinoline alkaloid extracted from Coptidis rhizoma...
  28. ncbi Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress
    Nicolas G Bazan
    LSU Neuroscience Center and Department of Opthamology, Louisiana State University Health Sciences Center School of Medicine, New Orleans 70112, USA
    Brain Pathol 15:159-66. 2005
    ....
  29. ncbi Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurotrauma 27:205-15. 2010
    ..These data demonstrate that EPO significantly provides neuroprotection following TBI, even in the absence of EPOR in the neural cells, suggesting that its therapeutic benefits may be mediated through vascular protection...
  30. ncbi Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats
    Amutha Selvamani
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Neurobiol Aging 31:1618-28. 2010
    ....
  31. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  32. ncbi Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models
    Elaine C Johnson
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Ceres, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Eye Res 88:808-15. 2009
    ..The examination of these studies in this review reveals a number of consistent observations and provides direction for further investigations of this hypothesis...
  33. ncbi Sex differences in minocycline-induced neuroprotection after experimental stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Cereb Blood Flow Metab 29:670-4. 2009
    ..Clinical trials must consider possible sex differences in the response to neuroprotective agents, if we hope to translate promising therapies to stroke patients of both sexes.
  34. ncbi Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas, Houston, Medical School, Houston, Texas 77030, USA
    J Neurosci 29:6186-95. 2009
    ..Therefore, we conclude that PPARgamma in neurons play an essential protective function and that PPARgamma agonists may have utility in neuronal self-defense, in addition to their well established anti-inflammatory effect...
  35. ncbi Neuroprotective effects of curcumin
    Greg M Cole
    Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education, and Clinic Center, Sepulveda, CA 91343, USA
    Adv Exp Med Biol 595:197-212. 2007
    ..Promising results have already led to ongoing pilot clinical trials...
  36. ncbi Modulation of the endocannabinoid system: neuroprotection or neurotoxicity?
    Christopher J Fowler
    Department of Pharmacology and Clinical Neuroscience, Umea University, SE 901 87 Umea, Sweden
    Exp Neurol 224:37-47. 2010
    ....
  37. ncbi Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
    P Klivenyi
    Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02118, USA
    Nat Med 5:347-50. 1999
    ..Creatine administration protected G93A transgenic mice from increases in biochemical indices of oxidative damage. Therefore, creatine administration may be a new therapeutic strategy for ALS...
  38. ncbi Nutraceutical antioxidants as novel neuroprotective agents
    Natalie A Kelsey
    Department of Biological Sciences and Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80208, USA
    Molecules 15:7792-814. 2010
    ..Here, we review the literature pertaining to these various classes of nutraceutical antioxidants and discuss their potential therapeutic value in neurodegenerative diseases...
  39. ncbi Neuroprotective strategies involving ROS in Alzheimer disease
    Magali Dumont
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Free Radic Biol Med 51:1014-26. 2011
    ..Nonetheless, there is still hope for improved compounds that would better target pathways implicated in ROS production. In fact, facilitating the endogenous antioxidant system by modulating transcription has great promise for AD therapy...
  40. ncbi Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, 1 1 Nakafudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Curr Pharm Des 16:2799-817. 2010
    ..the inhibitors of type B monoamine oxidase, such as selegiline and rasagiline, are the most promising neuroprotective agents to date. These inhibitors protect neuronal cells against cell death induced in cellular and animal models...
  41. ncbi Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners
    Keith A Wollen
    Psychology Department of Washington State University, USA
    Altern Med Rev 15:223-44. 2010
    ..Approaches that target several dysfunctions simultaneously and that emphasize nutritional, botanical, and stimulatory therapies may offer the most benefit at this time...
  42. ncbi Tetrahydrocurcumin confers protection against amyloid β-induced toxicity
    Shilpa Mishra
    National Brain Research Centre, Manesar, Haryana, India
    Neuroreport 22:23-7. 2011
    ..Thus, THC confers protection against amyloid-β-induced toxicity, and the antioxidant activity may contribute to its protective effect...
  43. ncbi Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury
    Xiaoyang Wang
    Department of Physiology, Perinatal Center, Sahlgrenska Academy, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Stroke 41:2050-5. 2010
    ..The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury...
  44. ncbi Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents
    Ravinder K Kaundal
    Department of Pharmacology and Toxicology of the National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Drug News Perspect 23:241-56. 2010
    ..This article discusses evidence and mechanisms supporting the neuroprotective effects of PPARgamma agonists in central nervous system disorders...
  45. ncbi Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury
    Suk Yee Li
    Eye Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e16380. 2011
    ..The present study suggests that LBP may have a neuroprotective role to play in ocular diseases for which I/R is a feature...
  46. ncbi Neuroprotective effects of female gonadal steroids in reproductively senescent female rats
    N J Alkayed
    Department of Anesthesiology, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 31:161-8. 2000
    ....
  47. ncbi Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection
    Z A Shah
    Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA
    Neuroscience 180:248-55. 2011
    ..Together, these results suggest that HO1 plays, at least in part, an important role in the neuroprotective mechanism of EGb 761 and in delayed ischemia. Targeting this pathway could lead to neuroprotective agents against ischemic stroke.
  48. ncbi Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    Kang Lu
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan
    J Neurochem 114:237-46. 2010
    ..Future research should focus on the possible cross-talk between the MEK/ERK pathway and the NF-kappaB transcriptional cascade...
  49. ncbi Actions of estrogens on glial cells: Implications for neuroprotection
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, Madrid, Spain
    Biochim Biophys Acta 1800:1106-12. 2010
    ..Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds...
  50. ncbi Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association
    Majid Fotuhi
    Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Sinai Hospital of Baltimore, Baltimore, MD 21209, USA
    Nat Clin Pract Neurol 5:140-52. 2009
    ..Large clinical trials of extended duration should help to provide definitive answers...
  51. ncbi Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways
    R D Almeida
    Center for Neuroscience and Cell Biology and Department of Zoology, University of Coimbra, 3004-517 Coimbra, Portugal
    Cell Death Differ 12:1329-43. 2005
    ..The results indicate that the protective effect of BDNF in hippocampal neurons against glutamate toxicity is mediated by the PI3-K and the Ras/MAPK signaling pathways, and involves a long-term change in protein synthesis...
  52. ncbi Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75
    C Culmsee
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Ketzerbach 63, 35032, Marburg, Germany
    Neuroscience 115:1089-108. 2002
    ..Overall, our results indicate an essential role for p75NTR in supporting NGF-triggered TrkA signaling pathways mediating neuronal survival in hippocampal neurons...
  53. ncbi The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats
    Antonio Ibarra
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Eur J Neurosci 19:2984-90. 2004
    ..These results demonstrate that the therapeutic window after SCI can accommodate immediate administration of MP plus a delayed therapeutic vaccination...
  54. ncbi Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases
    P A Lapchak
    Department of Neuroscience, University of California-San Diego, La Jolla, California 92093-0624, USA
    Int Rev Neurobiol 46:379-97. 2001
    ..2000), their potential therapeutic benefits may be extended to include the treatment of other neurodegenerative diseases not directly linked to excitotoxicity...
  55. ncbi Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia
    Helene N David
    NNOXe Pharmaceuticals, Quebec City, Quebec, Canada
    J Cereb Blood Flow Metab 29:1159-65. 2009
    ..In this study, we show that helium at 75 vol% produces neuroprotection and improvement of neurologic outcome in rats subjected to transient MCAO by producing hypothermia on account of its high specific heat as compared with air...
  56. ncbi The potential value of natural antioxidative treatment in glaucoma
    M Mozaffarieh
    Department of Ophthalmology, University Hospital Basel, Switzerland
    Surv Ophthalmol 53:479-505. 2008
    ..Anthocyanosides (bilberries) owe their antioxidant effects to their particular chemical structure. Other antioxidants include ubiquinone and melatonin...
  57. ncbi Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
    Philip D Loetscher
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    Crit Care 13:R206. 2009
    ..Since traumatic brain injury and stroke are widespread and generate an enormous economic and social burden, we investigated the possible neuroprotective effect in in vitro models of traumatic brain injury and cerebral ischemia...
  58. ncbi The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes
    S H Jung
    Nuffield Laboratory of Ophthalmology, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neurochem Int 53:325-37. 2008
    ..Significantly, the negative insult of serum withdrawal on RGC-5 cell survival was blunted by baicalin but not by EGCG revealing the different properties of the two flavonoids...
  59. ncbi Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage
    M Balestrino
    Department of Neurological and Vision Sciences, University of Genova, Italy
    Amino Acids 23:221-9. 2002
    ..Accordingly, preliminary data show that creatine pretreatment decreases ischemic damage in vivo...
  60. ncbi Pharmacological neuroprotection for glaucoma
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute, Adelaide, South Australia, Australia
    Drugs 67:725-59. 2007
    ....
  61. ncbi Hydrogen sulfide is a mediator of cerebral ischemic damage
    Kun Qu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Stroke 37:889-93. 2006
    ..CONCLUSIONS: The present results strongly suggest that H2S plays a part in cerebral ischemic damage after stroke. Inhibition of H2S synthesis should be investigated for its potential as a novel neuroprotective stroke therapy...
  62. ncbi Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation
    Andy Y Shih
    Kinsmen Laboratory of Neurological Research and Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 26:10514-23. 2006
    ..Furthermore, xCT is critical for cell proliferation during development in vitro and possibly in vivo...
  63. ncbi Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system
    Y Zhang
    Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1682, USA
    Stroke 32:1378-84. 2001
    ..The neuroprotection is long lasting and persists for at least 7 days after a 1-hour middle cerebral artery occlusion...
  64. ncbi Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
    Silvia A Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion-Faculty of Medicine, Haifa, Israel
    Neurosignals 14:46-60. 2005
    ..In particular, their transitional metal (iron and copper) chelating property and inhibition of oxidative stress...
  65. ncbi Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
    T Alexi
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Prog Neurobiol 60:409-70. 2000
    ..Considerable research has been done on testing a large array of neuroprotective agents using animal models which mimic these disorders...
  66. ncbi Peptide-mediated protection from ethanol-induced neural tube defects
    Shao Yu Chen
    Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Dev Neurosci 27:13-9. 2005
    ..These findings demonstrate the ability of NAP and SAL to prevent ethanol-induced NTDs and support the hypothesis that ethanol teratogenesis is caused in part by ethanol inhibition of L1-mediated cell adhesion...
  67. ncbi Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury
    Dunyue Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    J Neurotrauma 21:21-32. 2004
    ..The results suggest that atorvastatin may provide beneficial effects in experimental TBI...
  68. ncbi Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia
    In Koo Hwang
    Department of Anatomy, College of Medicine, Hallym University, Chunchon, 200-702, South Korea
    Life Sci 75:1989-2001. 2004
    ..Therefore, these results suggest that GSE can protect ischemic neuronal damage by inhibiting DNA damage after transient forebrain ischemia...
  69. ncbi EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
    ..These findings suggest that EGCG is a potent remodeling agent of mature amyloid fibrils...
  70. ncbi Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat
    Preeti Dohare
    Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, India
    Behav Brain Res 193:289-97. 2008
    ....
  71. ncbi Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells
    Julia Biermann
    University Eye Hospital Freiburg, Freiburg im Breisgau, Germany
    Invest Ophthalmol Vis Sci 51:526-34. 2010
    ..The authors investigated whether VPA delays retinal ganglion cell (RGC) death and enhances axonal regeneration after optic nerve crush (ONC). Furthermore, potential molecular targets involved in VPA-mediated protection were analyzed...
  72. ncbi Protective effects of estrogen and selective estrogen receptor modulators in the brain
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biol Reprod 67:1379-85. 2002
    ..The role of other potential mediatory factors such as growth factors and the possibility of an astrocyte role in neuroprotection is also discussed...
  73. ncbi Neuroprotective effects of resveratrol against traumatic brain injury in immature rats
    Ulker Sonmez
    Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, TR 35340 Izmir, Turkey
    Neurosci Lett 420:133-7. 2007
    ..These results show that acute treatment of resveratrol has a neuroprotective role against trauma induced hippocampal neuron loss and associated cognitive impairment in rats...
  74. ncbi Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax
    Moussa B H Youdim
    Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion, Efron Street, P O Box 9697, Haifa 31096, Israel
    Neuropharmacology 46:1130-40. 2004
    ..The neuroprotective action of lithium in this model of Parkinson's disease has been attributed to its antiapoptotic activity which among other factors includes induction of Bcl-2 and reduction of Bax...
  75. ncbi Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
    Michio Hashimoto
    Department of Physiology, Shimane Medical University, Izumo, Japan
    J Neurochem 81:1084-91. 2002
    ..Docosahexaenoic acid is thus a possible prophylactic means for preventing the learning deficiencies of Alzheimer's disease...
  76. ncbi Neuroprotective properties of statins in cerebral ischemia and stroke
    C J Vaughan
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, USA
    Stroke 30:1969-73. 1999
    ..In this article, we review the emerging evidence that statins have beneficial effects within the cerebral circulation and brain parenchyma during ischemic stroke and reperfusion...
  77. ncbi The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    Marwan Maalouf
    Department of Neurobiology, David Geffen School of Medicine, University of California, 63 323 CH5, Box 951763, Los Angeles, CA 90095 1763, USA
    Brain Res Rev 59:293-315. 2009
    ..The present review summarizes the neuroprotective effects of calorie restriction, of the ketogenic diet and of ketone bodies, and compares their putative mechanisms of action...
  78. ncbi Neuroprotective actions of brain aromatase
    Colin J Saldanha
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, United States
    Front Neuroendocrinol 30:106-18. 2009
    ....
  79. ncbi CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
    Barbara L Apostol
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    Mol Cell Neurosci 39:8-20. 2008
    ..These studies suggest a novel therapeutic approach for a currently untreatable neurodegenerative disease, HD, via CEP-1347 up-regulation of BDNF...
  80. ncbi The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
    Claudia Pitzer
    Sygnis Bioscience, Im Neuenheimer Feld, Heidelberg, Germany
    J Neurochem 113:930-42. 2010
    ..We show that G-CSF improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. We conclude that G-CSF constitutes a promising and feasible new therapy option for SCI...
  81. ncbi Cyanine dyes attenuate cerebral ischemia and reperfusion injury in rats
    Satomi Koya-Miyata
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc
    Biol Pharm Bull 33:1872-7. 2010
    ..These results suggest that NK-4 and NK-150 effectively prevented ischemia-induced brain injury through their potent neurotrophin-like activity as well as antioxidative activity...
  82. ncbi Current and future disease-modifying therapies in multiple sclerosis
    S Y Lim
    University of Nottingham, UK
    Int J Clin Pract 64:637-50. 2010
    ..It is also worth noting the evidence for starting DMT in patients with clinically isolated syndrome, whereby early treatment has shown to delay the onset of clinically definite MS in separate phase III studies...
  83. ncbi Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity
    Jun Lu
    Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P R China
    J Pathol 222:199-212. 2010
    ..These results suggest that AMPK activated by quercetin may be a potential target to enhance the resistance of neurons to age-related diseases...
  84. ncbi Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
    ..Thus, native PrP(C) mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits...
  85. ncbi Heat shock protein 90 mediates cytoprotection by H₂S against chemical hypoxia-induced injury in PC12 cells
    Jin Lan Meng
    Department of Physiology, Zhongshan Medical College, China
    Clin Exp Pharmacol Physiol 38:42-9. 2011
    ..01) and increasing ROS production. 7. The findings of the present study provide novel evidence that Hsp90 mediates H₂S-induced neuroprotection against chemical hypoxia-induced injury via anti-oxidant and anti-apoptotic effects...
  86. ncbi Protection of mouse photoreceptors by survival factors in retinal degenerations
    M M LaVail
    Department of Anatomy, University of California, San Francisco 94143 0730, USA
    Invest Ophthalmol Vis Sci 39:592-602. 1998
    ....
  87. ncbi Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity
    Cun Jian Dong
    Department of Biological Sciences, Allergan Pharmaceuticals, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 49:4515-22. 2008
    ..In this study, the authors investigated the neural mechanism that may underlie alpha2 neuroprotection of RGCs...
  88. ncbi Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Leukoc Biol 82:1083-94. 2007
    ..This neuroprotection was achieved through modulation of microglial oxidative stress and inflammation. As Tregs can be modulated in vivo, these data strongly support the use of such immunomodulatory strategies to treat PD...
  89. ncbi TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels
    Amalia M Dolga
    Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands
    J Neurochem 107:1158-67. 2008
    ..We conclude that treatment of primary cortical neurons with TNF-alpha leads to increased K(Ca)2.2 channel expression which renders neurons more resistant to excitotoxic cell death...
  90. ncbi Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats
    Jose A Morales-Garcia
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas, Madrid, Spain
    J Neurosci Res 87:3687-96. 2009
    ..Also, NP04634 prevented the loss of hippocampal CA1 and CA3 pyramidal neurons and reduced the gliosis induced by KA. These results point to a potential anticonvulsant and neuroprotective role for NP04634...
  91. ncbi Sample size estimates for clinical trials of vasospasm in subarachnoid hemorrhage
    Kurt T Kreiter
    Biogen Idec, Wellesley, MA, USA
    Stroke 40:2362-7. 2009
    ....
  92. ncbi Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia
    Yan qiu Cui
    Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing, China
    Clin Exp Pharmacol Physiol 37:422-8. 2010
    ..The results also suggest that this inhibitory action of fucoidan involves suppression of p38 and ERK phosphorylation...
  93. ncbi A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection
    Hulya Karatas
    Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    J Neurosci 29:13761-9. 2009
    ..Thus, chitosan nanospheres open new and exciting opportunities for brain delivery of biologically active peptides that are useful for the treatment of CNS disorders...
  94. ncbi Magnesium sulphate in the management of patients with aneurysmal subarachnoid haemorrhage: a meta-analysis of prospective controlled trials
    Li Ma
    Department of Neurosurgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, PR China
    Brain Inj 24:730-5. 2010
    ..A meta-analysis was conducted to assess the effectiveness and safety of intravenous magnesium therapy in patients with aneurysmal subarachnoid haemorrhage (SAH). Research design: Meta-analysis...
  95. ncbi Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model
    Huaqiu Zhang
    Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong, University of Science and Technology, Wuhan, 430030, PR China
    Brain Res 1247:196-211. 2009
    ....
  96. ncbi Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
    Katja Kanninen
    Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, Kuopio University, Kuopio, Finland
    Mol Cell Neurosci 39:302-13. 2008
    ..The findings suggest that the Nrf2-ARE pathway may be impaired in AD and that induction of the Nrf2-ARE defence mechanism may prevent or delay AD-like pathology...
  97. ncbi The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease
    Joana M Gil
    Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, BC, V8W 2Y2, Canada
    Brain Res Rev 59:410-31. 2009
    ..Although many of these treatments were beneficial in R6 mice, they may not be as effective in HD patients, and thus the search for a combination of therapies that will rescue the human condition continues...
  98. ncbi Survivin: a target from brain cancer to neurodegenerative disease
    Sara Baratchi
    Centre for Biotechnology and Interdisciplinary Biosciences BioDeakin, Institute for Technology Research and Innovation ITRI, Deakin University, Waurn Ponds, Victoria, Australia
    Crit Rev Biochem Mol Biol 45:535-54. 2010
    ..Due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases...
  99. ncbi Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study
    Nikunj K Patel
    Frenchay Hospital, Institute of Neurosciences, Bristol, United Kingdom
    Ann Neurol 57:298-302. 2005
    ....
  100. ncbi Both systemic and local application of granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy
    Tobias Frank
    Department of Neurology, University Medical Center Gottingen, Gottingen, Germany
    BMC Neurosci 10:49. 2009
    ..In addition, G-CSF provided neuroprotection in models of neuronal cell death. Here we used the retinal ganglion cell (RGC) axotomy model to compare effects of local and systemic application of neuroprotective molecules...
  101. ncbi Inflammatory mechanisms in ischemic stroke: therapeutic approaches
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    J Transl Med 7:97. 2009
    ..However, recent studies showing that regulatory T cells are major cerebroprotective immunomodulators after stroke suggest that targeting the endogenous adaptive immune response may offer novel promising neuroprotectant therapies...

Research Grants87

  1. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ..of observed effects are to be assessed, as well as effects produced when IL-1ra is combined with other neuroprotective agents such as MK-801...
  2. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
    ..ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute stroke, thrombolytic therapy for intraventricular hemorrhage, and ultra-early hemostatic therapy ..
  3. Molecular Interventions for Bipolar Disorder
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
    ..the pro-apoptotic properties of the GSK-3 enzyme suggest a potential use of such inhibitors as neuroprotective agents. Neuroprotection may further contribute to the therapeutic efficacy of mood disorder drugs...
  4. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2007
    ..the pro-apoptotic properties of the GSK-3 enzyme suggest a potential use of such inhibitors as neuroprotective agents. Neuroprotection may further contribute to the therapeutic efficacy of mood disorder drugs...
  5. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2009
    ..the pro-apoptotic properties of the GSK-3 enzyme suggest a potential use of such inhibitors as neuroprotective agents. Neuroprotection may further contribute to the therapeutic efficacy of mood disorder drugs...
  6. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..is that transplanted, genetically modified bone marrow-derived stem cells can be used as effective neuroprotective agents to mediate preservation and rescue of visual function in the rat model of experimental glaucoma...
  7. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2007
    ....
  8. Cerebal Ischemia During Anesthesia and Surgery
    Piyush Patel; Fiscal Year: 2004
    ..Anesthetics are logical candidate neuroprotective agents because they reduce excitotoxic injury...
  9. Parkinson's Disease Neuroprotection Clinical Center
    Charles Adler; Fiscal Year: 2005
    ..To this end creating a multi-center study group to run clinical trials of potential neuroprotective agents has been set as a goal of the NIH...
  10. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  11. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2009
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  12. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2007
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  13. HIGH-THROUGHPUT SCREENING ASSAY FOR NEUROPROTECTIVE AGENTS
    Karima Ferrani Kile; Fiscal Year: 2007
    ....
  14. Novel visual outcome measures in optic neuritis and multiple sclerosis
    Laura Balcer; Fiscal Year: 2007
    ..as new visual outcomes for clinical trials in MS, and in acute ON as a model system for future testing of neuroprotective agents. Specific Aim 2: Determine how new visual outcomes, low-contrast letter acuity and OCT, reflect vision-..
  15. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2009
    ..However, efforts to develop ionotropic glutamate receptor antagonists as neuroprotective agents have yet to be successful; alternative molecular targets for developing neuroprotective compounds need to ..
  16. Combination Drug Therapy in Huntington's Disease
    ROBERT FERRANTE; Fiscal Year: 2007
    ..compounds or their analogs are available for human use and represent the immediate pipeline of candidate neuroprotective agents for clinical trials in HD...
  17. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..However, efforts to develop ionotropic glutamate receptor antagonists as neuroprotective agents have yet to be successful;alternative molecular targets for developing neuroprotective compounds need to ..
  18. Phase II Trial of Tiopronin in Aneurysmal Subarachnoid Hemorrhage
    EDWARD SANDER CONNOLLY; Fiscal Year: 2010
    ..This would spark further study that could further explore neuroprotective pre-treatment of cerebral ischemia, and thus help neutralize a major source of morbidity and mortality in this disease process. ..
  19. A Novel Neuroprotective Approach for Ischemia
    Zhi Gang Jiang; Fiscal Year: 2007
    ..At the end of the phase II period, we expect to submit an IND application to the FDA to use PAN-811 for the treatment of transient ischemic stroke and initiate phase Ib clinical trials. ..
  20. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..study will demonstrate the feasibility of performing randomized, controlled clinical trials of promising neuroprotective agents in the field...
  21. Characterizing Beta Lactams/Neuroprotective Drugs/ALS
    Jeffrey Rothstein; Fiscal Year: 2006
    ..These sequential phases will set the stage for future practical translation towards rational clinical trial design. ..
  22. Peptidic Ligands for Kappa Opioid Receptors
    JANE ALDRICH; Fiscal Year: 2007
    ..Kappa receptor ligands also have a number of other potential therapeutic applications, including as neuroprotective agents and potentially in the treatment of AIDS...
  23. A HIGH-THROUGHPUT SCREEN FOR ANTI-NECROTIC COMPOUNDS
    DONALD KIRSCH; Fiscal Year: 2006
    ..2) Execute a pilot screen of -3000 highly selected compounds to identify neuroprotective agents. A library of known bioactive compounds, including many currently marketed drugs, will be screened for ..
  24. PARKINSON DISEASE NEUROPROTECTION CLINICAL TRIAL CENTER
    Bala Manyam; Fiscal Year: 2005
    ..abstract_text> ..
  25. Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MS
    Laura Balcer; Fiscal Year: 2010
    ..in MS clinical trials, particularly for the anticipated next generation of trials that will involve neuroprotective agents. While our cross-sectional, preliminary longitudinal, and clinical trial data represent a significant step ..
  26. BLOOD/BRAIN BARRIER DRUG DELIVERY OF BDNF IN ISCHEMIA
    William Pardridge; Fiscal Year: 2002
    Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are potential neuroprotective agents for the treatment of stroke, trauma, and neurodegenerative diseases...
  27. Neurotrophin Blood/Brain Barrier Delivery in Ischemia
    William Pardridge; Fiscal Year: 2006
    Neurotrophins are powerful neuroprotective agents in global or regional brain ischemia when the protein is injected directly into the ischemic brain...
  28. Endogenous neuroprotective agents in Parkinson's disease
    Amanda Smith; Fiscal Year: 2007
    ..The mentors that are described herein will actively participate in this undertaking and will further mediate increasing the network of neuroscientists in which I interact locally and nationally. ..