oxidants

Summary

Summary: Oxidizing agents or electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). In vivo, it appears that phagocyte-generated oxidants function as tumor promoters or cocarcinogens rather than as complete carcinogens perhaps because of the high levels of endogenous antioxidant defenses. It is also thought that oxidative damage in joints may trigger the autoimmune response that characterizes the persistence of the rheumatoid disease process.

Top Publications

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
  3. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
  4. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
  5. ncbi A new automated colorimetric method for measuring total oxidant status
    Ozcan Erel
    Department of Clinical Biochemistry, Faculty of Medicine, Research Hospital, Harran University, Sanliurfa TR 63100, Turkey
    Clin Biochem 38:1103-11. 2005
  6. pmc Oxidants, antioxidants and the current incurability of metastatic cancers
    Jim Watson
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Open Biol 3:120144. 2013
  7. ncbi Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    S L Hempel
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Free Radic Biol Med 27:146-59. 1999
  8. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
  9. pmc Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction
    Amy M Furda
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    DNA Repair (Amst) 11:684-92. 2012
  10. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006

Detail Information

Publications305 found, 100 shown here

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and ..
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  3. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
    ..and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently with thiols at rates that are closely related to their potencies...
  4. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
    ..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...
  5. ncbi A new automated colorimetric method for measuring total oxidant status
    Ozcan Erel
    Department of Clinical Biochemistry, Faculty of Medicine, Research Hospital, Harran University, Sanliurfa TR 63100, Turkey
    Clin Biochem 38:1103-11. 2005
    ..To develop a new, colorimetric and automated method for measuring total oxidation status (TOS)...
  6. pmc Oxidants, antioxidants and the current incurability of metastatic cancers
    Jim Watson
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Open Biol 3:120144. 2013
    ..A much faster timetable should be adopted towards developing more new drugs effective against p53(- -) cancers...
  7. ncbi Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    S L Hempel
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Free Radic Biol Med 27:146-59. 1999
    ..tests the hypothesis that dihydrofluorescein diacetate is a better fluorescent probe for detecting intracellular oxidants because it is more reactive toward specific oxidizing species...
  8. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ..NO2), formed as secondary products of (.)NO metabolism in the presence of oxidants including superoxide radicals (O2(.-)), hydrogen peroxide (H2O2), and transition metal centers...
  9. pmc Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction
    Amy M Furda
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    DNA Repair (Amst) 11:684-92. 2012
    ..These results suggest that persistent mtDNA damage is not sufficient to cause mitochondrial dysfunction...
  10. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
    ..The antioxidant species help the lungs ward off the deleterious consequences of a wide variety of oxidants/reactive oxygen species such as superoxide anion, hydroxyl radical, hypohalite radical, hydrogen peroxide and ..
  11. ncbi Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators
    Colette T Dooley
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093 0647, USA
    J Biol Chem 279:22284-93. 2004
    ..C48S, S147C, and Q204C) and roGFP2 (the same plus S65T) with physiologically or toxicologically relevant oxidants both in vitro and in living mammalian cells...
  12. ncbi The role of oxidants and free radicals in reperfusion injury
    Jay L Zweier
    Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
    Cardiovasc Res 70:181-90. 2006
    ..NO and peroxynitrite can inhibit pathways of oxygen radical generation, and, in turn, oxidants can inhibit NO synthesis from NOS...
  13. ncbi Oxidant signals and oxidative stress
    Toren Finkel
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Curr Opin Cell Biol 15:247-54. 2003
    Although oxidants clearly possess the capacity to behave in a random and destructive fashion, growing evidence suggests that in many instances the production of reactive oxygen species is tightly regulated and their downstream targets ..
  14. ncbi The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself
    I Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Free Radic Biol Med 31:1624-32. 2001
    ..Although the microfilament network is one of the earliest targets of oxidative stress, the mechanism by which oxidants change both the structure and the spatial organization of actin filaments is still a matter of debate and far ..
  15. pmc Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense
    Jacob M Rothfork
    Research Service, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    Proc Natl Acad Sci U S A 101:13867-72. 2004
    ..Here, we show that phagocyte-derived oxidants target these autoinducers for inactivation as an innate defense mechanism of the host...
  16. pmc SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    Samuel Caito
    Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    FASEB J 24:3145-59. 2010
    ..b>Oxidants, aldehydes, and CS induced carbonyl modifications on SIRT1 on cysteine residues concomitant with decreased SIRT1 ..
  17. ncbi Oxidants, antioxidants and the ischemic brain
    David S Warner
    Department of Anesthesiology, The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Biol 207:3221-31. 2004
    ..Because oxidative stress involves multiple post-ischemic cascades leading to cell death, effective prevention/treatment of ischemic brain injury is likely to require intervention at multiple effect sites...
  18. ncbi Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins
    Samuel M S Cheung
    Department of Immunology, University of Manitoba, 730 William Avenue, Winnipeg, MB Canada R3E 0W3
    Cell Signal 19:902-12. 2007
    ..Our results indicate that exogenous and endogenous superoxides can modulate the quality of the PI3K signal in lymphocytes by selectively increasing PI(3,4)P2-dependant signaling...
  19. ncbi Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications
    P Calcerrada
    Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800, Montevideo, Uruguay
    Curr Pharm Des 17:3905-32. 2011
    ..Although nitric oxide is a mildly reactive intermediary, it can act as a precursor of strong oxidants under pathological conditions associated with oxidative stress including cardiovascular, inflammatory and ..
  20. ncbi Oxidants in chronic kidney disease
    Sudhir V Shah
    University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 501, Little Rock, AR 72205, USA
    J Am Soc Nephrol 18:16-28. 2007
    ..This review defines the term reactive oxygen metabolites (ROM), or oxidants, and presents the available experimental evidence in support of the role of oxidants in diabetic and nondiabetic ..
  21. pmc Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, University of Chicago, Chicago, IL, USA
    Am J Physiol Heart Circ Physiol 298:H2164-73. 2010
    ..We conclude that TH cardioprotection is mediated by enhanced Akt/HSP27 phosphorylation and enhanced NO generation, resulting in the attenuation of ROS generation and the maintenance of DeltaPsim following ischemia-reperfusion...
  22. ncbi Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing
    Christine C Winterbourn
    Department of Pathology, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 281:39860-9. 2006
    ..However, the role of oxidants in killing and the species responsible are poorly understood and the subject of current debate...
  23. ncbi MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants
    J F Buckman
    Department of Pharmacology, University of Pittsburgh, E1351 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Neurosci Methods 104:165-76. 2001
    ....
  24. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998
    ..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
  25. pmc Signal transduction by mitochondrial oxidants
    Toren Finkel
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4434-40. 2012
    ..Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules...
  26. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..We have examined its reactivity with various biological oxidants, in order to assess its ability to act as a direct physiological target for these species...
  27. pmc Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Nashville, Tennessee, USA
    J Clin Invest 111:583-93. 2003
  28. pmc Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
    Saul Soberanes
    Division of Pulmonary and Critical Care Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2176-86. 2009
    ..We conclude that particulate matter air pollution induces the generation of ROS primarily from site III of the mitochondrial electron transport chain and that these ROS activate the intrinsic apoptotic pathway through ASK1, JNK, and p53...
  29. pmc NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    H Kono
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    J Clin Invest 106:867-72. 2000
    ..To test the hypothesis that NADPH oxidase is the major source of oxidants due to ethanol, we used p47(phox) knockout mice, which lack a critical subunit of this major source of reactive ..
  30. ncbi Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells
    Annika Höhn
    Institute of Biological Chemistry and Nutrition, Department of Biofunctionality and Food Safety, University of Hohenheim, 70593 Stuttgart, Germany
    Free Radic Biol Med 48:1100-8. 2010
    ..In this study for the first time the lipofuscin-mediated formation of oxidants and the role of iron in this process are directly shown in a model of senescent fibroblasts, as well as in vitro ..
  31. pmc Toll-like receptor 2 is essential for the sensing of oxidants during inflammation
    Mark J Paul-Clark
    Cardiothoracic Pharmacology, Cardiothoracic and Stem Cell Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 179:299-306. 2009
    The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood.
  32. pmc Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
    Jean Cadet
    Direction des Sciences de Matière, Institut Nanosciences et Cryogenie, CEA Grenoble, Grenoble Cedex 9, France
    Free Radic Res 46:367-81. 2012
    ....
  33. ncbi Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease
    Shasi V Kalivendi
    Center for Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India
    Free Radic Biol Med 48:377-83. 2010
    ..Using parkinsonism mimetics (MPP(+), rotenone) and related oxidants, we have identified an oxidant-induced alternative splicing of alpha-syn mRNA, generating a shorter isoform of ..
  34. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
    ..Collectively, our results show that Spx is a major stress gene regulator and is implicated in the pathophysiology of E. faecalis. The relationship of Spx to other oxidative stress regulators is also discussed...
  35. pmc Subcellular targeting of oxidants during endothelial cell migration
    Ru Feng Wu
    University of Texas Southwestern, Dallas, TX 75390, USA
    J Cell Biol 171:893-904. 2005
    Endogenous oxidants participate in endothelial cell migration, suggesting that the enzymatic source of oxidants, like other proteins controlling cell migration, requires precise subcellular localization for spatial confinement of ..
  36. ncbi Cellular response to cigarette smoke and oxidants: adapting to survive
    André M Cantin
    Pulmonary Division, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue N, Sherbrooke, PQ, J1H 5N4 Canada
    Proc Am Thorac Soc 7:368-75. 2010
    The gaseous and soluble phases of cigarette smoke are sources of oxidants that contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD)...
  37. ncbi Microbial and host cells acquire enhanced oxidant-scavenging abilities by binding polyphenols
    Isaac Ginsburg
    The Faculty of Dental Medicine, Institute for Dental Sciences, Hebrew University, Hadassah Medical Center, P O Box 12065, Jerusalem 91120, Israel
    Arch Biochem Biophys 506:12-23. 2011
    ..cavity, metabolized polyphenols might be beneficial in the gastrointestinal tract to counteract the toxicity of oxidants and also of the sequelae of inflammatory processes...
  38. ncbi Cancer cell killing via ROS: to increase or decrease, that is the question
    Jie Wang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:1875-84. 2008
    ..In clinical setting individualized choice of an optimal ROS-manipulation therapy may require accurate and convenient measurements for ROS as well as "redox signaling signature" for prediction of efficacy and systemic toxicity...
  39. ncbi Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest
    Sebastián Carballal
    Laboratorio De Enzimologia, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay
    Free Radic Biol Med 50:196-205. 2011
    ..possible antioxidant role, we investigated the reactivity of hydrogen sulfide with several one- and two-electron oxidants. The rate constant of the direct reaction with peroxynitrite was (4.8±1.4)×10(3)M(-1) s(-1) (pH 7.4, 37°C)...
  40. pmc Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction
    Chunhua Cao
    Div of Nephrology, N3W143, 22 S Greene St, UMMS, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 299:F1056-64. 2010
    ..Intrinsic NO production does not affect DVR permeability to hydrophilic solutes...
  41. ncbi Interactions of oxidants with vascular signaling systems
    M S Wolin
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Arterioscler Thromb Vasc Biol 20:1430-42. 2000
    ....
  42. pmc FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    Arunima Sengupta
    Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:7468-78. 2011
    ..These data support a critical role for FoxOs in promoting cardiomyocyte survival during conditions of oxidative stress through induction of antioxidants and cell survival pathways...
  43. ncbi Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells
    Jacob J Briedé
    Netherlands Toxicogenomics Centre, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Toxicol Sci 114:193-203. 2010
    ..insight in the similarities and differences of the time-dependent oxidative stress responses induced by the oxidants H(2)O(2) and menadione and show that these can be discriminated regarding their modulation of particular colon ..
  44. ncbi Antioxidant function of cytosolic sources of NADPH in yeast
    K I Minard
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA
    Free Radic Biol Med 31:832-43. 2001
    ..In the absence of exogenous oxidants, however, loss of ZWF1 and IDP2, but not loss of CTT1 and CCP1, was found to be detrimental not only to growth ..
  45. ncbi Oxidant stress is increased during treatment of human immunodeficiency virus infection
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    Clin Infect Dis 37:1711-7. 2003
    ..Oxidant stress associated with therapeutic control of viral replication may have important implications for long-term complications of antiretroviral therapy...
  46. ncbi Effects of oxidants and antioxidants on proliferation of endometrial stromal cells
    Nastaran Foyouzi
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 82:1019-22. 2004
    ..To evaluate the effects of oxidative stress and antioxidants on proliferation of endometrial stromal cells...
  47. ncbi Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    Ernst Malle
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Biochim Biophys Acta 1761:392-415. 2006
    ..The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, ..
  48. ncbi Oxidants in the gas phase of cigarette smoke pass through the lung alveolar wall and raise systemic oxidative stress
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Kyuban cho, Nishinomiya, Japan
    J Pharmacol Sci 103:275-82. 2007
    ..Aqueous cigarette smoke extract (CSE) contains stable oxidants, peroxynitrite-like reactants, which have the ability to oxidize and nitrate low-density lipoprotein (LDL)...
  49. pmc Myeloperoxidase: a target for new drug development?
    E Malle
    Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Br J Pharmacol 152:838-54. 2007
    ..MPO participates in innate immune defence mechanism through formation of microbicidal reactive oxidants and diffusible radical species...
  50. ncbi Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells
    S Buder-Hoffmann
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Respir Cell Mol Biol 24:405-13. 2001
    ..Our results suggest that ERKs mediate cell-cycle alterations during the development of epithelial cell apoptosis or proliferation by diverse ERK stimuli...
  51. ncbi Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  52. ncbi Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants
    Hajo Haase
    Institute of Immunology, University Hospital RWTH Aachen, Germany
    Biometals 18:333-8. 2005
    ..Zinc deficiency activates stress pathways and may result in a loss of tyrosine phosphatase control, thereby causing insulin resistance...
  53. ncbi A novel assay for replicative lifespan in Saccharomyces cerevisiae
    Stefanie Jarolim
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria
    FEMS Yeast Res 5:169-77. 2004
    ..for assaying replicative lifespan in yeast, and apply it in a screening of mutants that are resistant to pro-oxidants. The assay reproduces the lifespan-shortening effects of deleting SIR2 and of growth in the presence of paraquat, ..
  54. pmc Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide
    Marco Palma
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Bacteriol 186:248-52. 2004
    Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls...
  55. pmc Hydrogen peroxide as a signal controlling plant programmed cell death
    Tsanko S Gechev
    Department Molecular Biology of Plants, Researchschool GBB, University of Groningen, 9751 NN, Haren, Netherlands
    J Cell Biol 168:17-20. 2005
    ..This review also describes a novel link between H2O2 and sphingolipids, two signals that can interplay and regulate plant cell death...
  56. ncbi Oxidants, antioxidants and carcinogenesis
    Gibanananda Ray
    Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India
    Indian J Exp Biol 40:1213-32. 2002
    ..NO can stimulate O2*-/H2O2/*OH-induced LPO. These deleterious actions of oxidants can be countered by antioxidant defence system in humans...
  57. ncbi Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD
    Diego G Espinosa-Heidmann
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 47:729-37. 2006
    ..This study was an investigation of the effects of cigarette smoke (CS) and HQ in the development of sub-RPE deposits in an experimental mouse model...
  58. ncbi The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
    ..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome...
  59. ncbi Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
    Arvind Dasari
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:10805-14. 2006
    ..This study delineates for the first time the molecular mechanisms that modulate caveolin-1 gene transcription upon oxidative stress and brings new insights into the redox control of cellular senescence in both normal and cancer cells...
  60. pmc Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
    ..cells treated with H2O2 as well as growing under conditions known or suspected to affect the level of endogenous oxidants. Thirty- to 60-min exposure of cells to 100 or 200 microM H2O2 led to an increase in the level of H2AX ..
  61. ncbi Effects of chronic mild stress on the oxidative parameters in the rat brain
    Giancarlo Lucca
    Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Universidade do Extremo Sul Catarinense, Criciuma, Criciuma, SC, Brazil
    Neurochem Int 54:358-62. 2009
    ..In conclusion, our results support the idea that stress produces oxidants and an imbalance between superoxide dismutase and catalase activities that contributes to stress-related diseases,..
  62. pmc Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
    Narsa M Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 37:3-8. 2007
    ..Our data suggest that dysfunctional Nrf2-regulated GSH-induced signaling is associated with deregulation of type II cell proliferation, which contributes to abnormal injury and repair and leads to respiratory impairment...
  63. ncbi Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation
    Jonathan P Brennan
    Department of Cardiology, King s College London, The Rayne Institute, St Thomas Hospital, London, SE1 7EH United Kingdom
    J Biol Chem 281:21827-36. 2006
    ..In essence, type I PKA contains protein thiols that operate as redox sensors, and their oxidation by hydrogen peroxide directly activates the kinase...
  64. ncbi Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    Thorsten Diemer
    Department of Physiology and Biophysics, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 7342, USA
    Endocrinology 144:2882-91. 2003
    ..This mechanism likely contributes to a host of pathophysiological events evident in testicular disorders such as infection, reperfusion injury, aging, cryptorchidism, and varicocele...
  65. ncbi Protective role of magnesium in cardiovascular diseases: a review
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
    Mol Cell Biochem 238:163-79. 2002
    ..Further research are needed for the incorporation of these findings toward the development of novel myocardial protective role of Mg2+ to reduce morbidity and mortality of patients suffering from a variety of cardiac diseases...
  66. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
    b>Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from prokaryotes to mammals have evolved with an elaborate and redundant complement of antioxidant defenses to confer protection against oxidative insults...
  67. ncbi Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
    W MacNee
    Respiratory Medicine, ELEGI, Colt Research Laboratories, Wilkie Building, Medical School, Teviot Place, EH8 9AG, Edinburgh, UK
    Trends Mol Med 7:55-62. 2001
    ..Antioxidants should therefore not only protect against the direct injurious effects of oxidants, but also may fundamentally alter the inflammatory events which have a central role in the pathogenesis of COPD.
  68. ncbi Quantification of protein modification by oxidants
    Clare L Hawkins
    The Heart Research Institute, Camperdown, NSW, Australia
    Free Radic Biol Med 46:965-88. 2009
    ..Exposure of proteins to these oxidants results in loss of the parent amino acid residue, formation of unstable intermediates, and the generation of ..
  69. ncbi The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants
    Angana Mukherjee
    Centre de Recherche en Infectiologie et Division de Microbiologie, Universite Laval, Quebec, Canada, G1V 4G2
    Mol Microbiol 74:914-27. 2009
    ..All phenotypes were reverted in the add-back mutant, thus proving the importance of thiols in dealing with oxidants including the action of antimonials.
  70. ncbi The antioxidant role of coenzyme Q
    Magnus Bentinger
    Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden
    Mitochondrion 7:S41-50. 2007
    ..An increase in CoQ concentration in specific cellular compartments in the presence of various types of oxidative stress appears to be of considerable interest...
  71. pmc Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
    Maddalena Fratelli
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 99:3505-10. 2002
    ..To this purpose, we radiolabeled cellular glutathione with (35)S, exposed T cells to oxidants (diamide or hydrogen peroxide), and performed nonreducing, two-dimensional electrophoresis followed by detection ..
  72. ncbi Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
    Antioxid Redox Signal 10:739-53. 2008
    ..This review summarizes the recent progress concerning how redox status can be modulated and how it regulates gene transcription during the development of ARDS, as well as the therapeutic implications...
  73. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
    ..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4...
  74. ncbi A caspase-related protease regulates apoptosis in yeast
    Frank Madeo
    Institute for Physiological Chemistry, University of Tubingen, Hoppe Seyler Strasse 4, 72076 Tubingen, Germany
    Mol Cell 9:911-7. 2002
    ..We conclude that Yor197w indeed functions as a bona fide caspase in yeast and propose the name Yeast Caspase-1 (YCA1, gene YCA1)...
  75. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  76. ncbi Oxidants/antioxidants and COPD
    W MacNee
    Edinburgh Lung Environmental Group Initiative, Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland, UK
    Chest 117:303S-17S. 2000
    Oxidative stress results from an oxidant/antioxidant imbalance, an excess of oxidants and/or a depletion of antioxidants...
  77. ncbi Evaluation of equol function on anti- or prooxidant status in vivo
    E J Choi
    Cancer Research Inst, The Catholic Univ of Korea, Seocho Gu, Seoul, Republic of Korea
    J Food Sci 74:H65-71. 2009
    ....
  78. pmc Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants
    Jacek Zielonka
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Arch Biochem Biophys 456:39-47. 2006
    ..Addition of tert-butanol, DMSO, and potassium bromide to the Fenton's system caused inhibition of 2-OH-E+ formation. Results indicate that reducing and oxidizing radicals have differential effects on the formation of 2-OH-E+...
  79. ncbi Methods to measure the reactivity of peroxynitrite-derived oxidants toward reduced fluoresceins and rhodamines
    Peter Wardman
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom
    Methods Enzymol 441:261-82. 2008
    ..The reduced dyes are reactive toward peroxynitrite, although probably not directly but via free radical oxidants derived from it: hydroxyl, carbonate, and nitrogen dioxide free radicals...
  80. ncbi Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
    Erez Koren
    Department of Pharmaceutics, School of Pharmacy, Hadassah Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Exp Biol Med (Maywood) 235:689-99. 2010
    ..Further studies are needed to determine the faith of polyphenols in the circulation and their sequestration in the spleen...
  81. ncbi Human adipose stem cell-conditioned medium increases survival of Friedreich's ataxia cells submitted to oxidative stress
    Jonathan Jones
    Neuroscience Institute UMH CSIC, University Miguel Herna ndez, San Juan, Spain
    Stem Cells Dev 21:2817-26. 2012
    ..Also, this work shows how neurotrophic factors, particularly BDNF, are capable of increasing cell survival in response to oxidative stress, which occurs in many neurodegenerative diseases...
  82. pmc Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:1940-5. 2006
    ..live cells undergoes continuous oxidative damage caused by metabolically generated endogenous as well as external oxidants and oxidant-inducers...
  83. ncbi Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids
    David I Pattison
    The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia
    Free Radic Res 46:975-95. 2012
    ..physiological conditions are hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN), with the ratio of these oxidants critically dependent on the concentration of thiocyanate ions (SCN⁻)...
  84. ncbi Role of oxidants and antioxidants in atherosclerosis: results of in vitro and in vivo investigations
    Rüdiger Siekmeier
    Federal Institute for Drugs and Medical Devices BfArM, Bonn, Germany
    J Cardiovasc Pharmacol Ther 12:265-82. 2007
    Both in vitro and in vivo studies have shown that oxidants are central in the development of atherosclerosis...
  85. pmc Oxidants, metabolism, and stem cell biology
    Jie Liu
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Free Radic Biol Med 51:2158-62. 2011
    ..These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.
  86. pmc Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants
    J J Yang
    Department of Medicine and Hypertension, Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
    Am J Pathol 158:581-92. 2001
    ..Coincident induction of apoptosis and/or the generation of intracellular oxidants were monitored...
  87. pmc Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
    Qi Chen
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:11105-9. 2008
    ..Similar pharmacologic concentrations were readily achieved in humans given ascorbate intravenously. These data suggest that ascorbate as a prodrug may have benefits in cancers with poor prognosis and limited therapeutic options...
  88. pmc Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species
    Elisa Couto Gomes
    Department of Biochemistry and Immunology, Institute of Biological Science, Federal University of Minas Gerais UFMG, Belo Horizonte, MG, Brazil
    Oxid Med Cell Longev 2012:756132. 2012
    ..This is a new area of study that promises important findings in the sphere of molecular and cellular mechanisms involved in the relationship between oxidative stress and exercise...
  89. ncbi Advanced glycation end product homeostasis: exogenous oxidants and innate defenses
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1126:46-52. 2008
    ..Data in humans confirm the hypothesis that advanced glycation end products (AGEs) and other oxidants derived from the diet may be major contributors to increased OS in normal adults as well as those with diabetes ..
  90. ncbi Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations
    Ewald Schröder
    King s College London, Department of Cardiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Curr Opin Pharmacol 8:153-9. 2008
    ..However, the intracellular H(2)O(2) may only ever reach 1-15% of the applied exogenous concentration...
  91. ncbi Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst
    Vincent H Ng
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Microbiol 52:1291-302. 2004
    ..These results indicate that the major role of KatG in MTB pathogenesis is to catabolize the peroxides generated by the phagocyte NADPH oxidase; in the absence of this host antimicrobial mechanism, KatG is apparently dispensable...
  92. ncbi Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia
    Robert Kraft
    Institut fur Pharmakologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Thielallee 69 73, 14195 Berlin, Germany
    Am J Physiol Cell Physiol 286:C129-37. 2004
    ..The increased sensitivity to H2O2 in LPS-stimulated cells suggests a role for TRPM2 in the calcium signaling of activated microglia...
  93. ncbi Low-molecular-weight oxidants involved in disulfide bond formation
    Lloyd W Ruddock
    Department of Biochemistry, University of Oulu, Finland
    Antioxid Redox Signal 16:1129-38. 2012
    ..Hence knowledge of the mechanisms for their formation is critical for understanding a myriad of cellular processes and associated disease states...
  94. pmc Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13
    Junmei Chen
    Research Division, Puget Sound Blood Center, Seattle, WA, USA
    Blood 115:706-12. 2010
    ..Taken together, these findings indicate that reactive oxygen species released by activated neutrophils have a prothrombotic effect, mediated in part by inhibition of VWF cleavage by ADAMTS13...
  95. pmc Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis
    E Gottlieb
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 20:5680-9. 2000
    ..of Bcl-x(L) on the cellular redox state after treatment with tumor necrosis factor alpha (TNF-alpha) or exogenous oxidants. We show that in cells that undergo TNF-alpha-induced apoptosis, TNF-alpha induces a partial decrease in ..
  96. ncbi The carbonate radical and related oxidants derived from bicarbonate buffer
    Danilo B Medinas
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    IUBMB Life 59:255-62. 2007
    ..reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate-carbon dioxide pair...
  97. pmc Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization
    John J Reiners
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 50:281-94. 2011
    ..cholesterol/sterol content modulates susceptibility to ROS-induced LMP and possibly does so by being an alternative target for oxidants and lowering the probability of damage to other lysosomal membrane lipids and/or proteins.
  98. ncbi Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases
    D I Pattison
    The Heart Research Institute, 114 Pyrmont Bridge Rd, Camperdown, Sydney, NSW 2050, Australia
    Curr Med Chem 13:3271-90. 2006
    ..A key function of MPO is the production of hypohalous acids (HOX, X = Cl, Br) which are strong oxidants with potent antibacterial properties...
  99. ncbi Hydrogen peroxide induces neurite degeneration: Prevention by tocotrienols
    Koji Fukui
    Physiological Chemistry Laboratory, Department of Bioscience and Engineering, College of Systems Engineering and Sciences, Shibaura Institute of Technology, Fukasaku 307, Minuma ku, Saitama, 337 8570, Japan
    Free Radic Res 45:681-91. 2011
    ..Treatment with tocotrienols may protect neurite function through its neuroprotective function...
  100. ncbi Serum oxidant and antioxidant status during early and late recovery periods following an all-out 21-km run in trained adolescent runners
    Ye Tian
    China Institute of Sport Science, 11 Tiyuguan Road, Chongwen District, Beijing, China
    Eur J Appl Physiol 110:971-6. 2010
    ....
  101. pmc Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Free Radic Biol Med 49:1273-82. 2010
    ..RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney...

Research Grants74

  1. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..The immediate career goals of the candidate, Dr. Roby Greenwald, are to examine the respiratory response to inhaled oxidants, specifically, the influence of air pollution mixtures on markers of airway inflammation and oxidative stress...
  2. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..Once activated, MPO generates a wide variety of potent oxidants and secondary radicals...
  3. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..composition of their cell surface (including content of D-alanine and cardiolipin) and to induce cytoplasmic anti-oxidants (e.g...
  4. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..Ca2+ influx, and consequent neuronal damage;these mechanistic considerations account for the fact that anti- oxidants and NMDAR antagonists can prevent cyanide-induced neuronal damage...
  5. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..decline in lung function) and chronic inflammation of the lungs due to inhaled cigarette smoke-derived oxidants and free radicals which are implicated in aging, senescence, cancer and inflammatory processes...
  6. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..Nrf2, a zinc-finger protein that turns on a genetic program that stimulates the production of multiple anti-oxidants including glutathione...
  7. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..Evidence for importance of free radicals and oxidants in PDN is emerging from both animal and human studies, but the mechanisms are not well understood...
  8. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..light and molecular oxygen, is characterized by local generation of singlet oxygen and other cytotoxic oxidants. When subjected to PDT-induced oxidative stress, many tumors succumb to apoptotic cell death, and much has been ..
  9. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David R Jacobs; Fiscal Year: 2013
    ..our understanding of the evolution of oxidative stress and its interaction with obesity, inflammation, sources of oxidants and dietary intakes in disease risk...
  10. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David Jacobs; Fiscal Year: 2009
    ..our understanding of the evolution of oxidative stress and its interaction with obesity, inflammation, sources of oxidants and dietary intakes in disease risk...
  11. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..than treating the enzymes with reactive oxygen compounds, photochemically generated one-electron, outer-sphere oxidants covalently bound to the protein periphery will be used to remove electrons from the resting enzyme and produce ..
  12. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2013
    ..It is our hope that identifying specific sources of oxidants will allow targeted therapy to prevent diabetic nephropathy and our long-term goal is to move our findings into ..
  13. A novel role for endogenous fructose in ischemic acute kidney injury
    MIGUEL ANGEL LANASPA GARCIA; Fiscal Year: 2013
    ..metabolism of fructose by the enzyme fructokinase results in ATP depletion and the generation of uric acid and oxidants causing acute tubulointerstitial injury...
  14. Estrogens, androgens, aging, and bone loss in males
    Stavros C Manolagas; Fiscal Year: 2013
    ..skeleton and the adverse effects of the loss of ovarian or testicular function on bone can be prevented by anti-oxidants. Conversely, estrogens or non-aromatizable androgens decrease oxidative stress...
  15. Regulation of the Expression of G[alpha]i2 by Reactive Oxygen Species
    Ifeanyi J Arinze; Fiscal Year: 2012
    ..They can be induced by drugs, environmental oxidants, and stress-inducing chemicals...
  16. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..a unique system of transcriptional control, mediated by the protein Spx, that functions in the response to toxic oxidants, including those produced by phagocytic immune cells...
  17. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2013
    ..in the lung endothelium of both mice and humans with SCD, suggesting that this enzyme affords protection against oxidants in SCD...
  18. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..survival in human PMNs in vitro, adherence to human esophageal tissue, quorum sensing and adaptation to oxidants. These features make two-component proteins very attractive targets for antifungal drug discovery since they have ..
  19. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..inhibitors o PCa specific ROS generation pathway(s) will be more effective than are chemical and/or dietary anti-oxidants in preventing PCa recurrence and progression to CRPCa...
  20. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The lungs are constantly exposed to oxidants both from environmental pollutants and from normal cellular metabolism...
  21. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    ..for formation of dysfunctional HDL, evidence points to a role for neutrophils myeloperoxidase (MPO)-generated oxidants as participants in rendering HDL dysfunctional...
  22. Aging and Apoptosis
    Brian A Herman; Fiscal Year: 2012
    ..caspase-2 liver specific (caspase-2L'~\ caspase-2 brain specific (caspase-28'^) and WT mice to various oxidants stressors_both in vitro and in vivo...
  23. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..The hypothesis is that oxidants formed from smoke interact the tissues in the airway to cause the release of chemokines the latter activate PMNs ..
  24. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2013
    ..the SERCA C674 thiol is a key physiological mediator of 7NO action in SMC whose role is prevented by elevated oxidants associated with disease...
  25. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..We hypothesize that aniline-induced oxidative stress due to over-production of oxidants (ROS and RNS) activates redox-sensitive transcription factors (NF-kappaB and AP-1) leading to transcription of ..
  26. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..mutant should have a significant impact on general understanding of the disease, potential use of anti-oxidants combined with IM as therapeutic agents, and targeting the particular leukemia cell sub-population in future ..
  27. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..By uncovering the details of how different enzymes deal with oxidants and how they relate or differ from each other this project will improve our understanding of oxidative stress, ..
  28. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..secondary to oxidative stress and some clinical studies have indicated that prophylactic administration of anti-oxidants may be useful in its prevention...
  29. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2011
    ..We previously hypothesized that anti- oxidants, such as N-acetylcysteine or vitamin C, decrease tumorigenesis by interfering with genomic instability by ..
  30. Regulation of Neutrophilic Lung Inflammation
    John W Christman; Fiscal Year: 2013
    ..of neutrophilc lung inflammation through effects on the production of anti-inflammatory prostanoids and anti-oxidants and detoxifying proteins regulated by Nrf2...
  31. Mesothelioma inhibition by secoisolariciresinol diglucoside (SDG)
    Melpo Christofidou-Solomidou; Fiscal Year: 2013
    ..In addition to damaging macromolecules, such oxidants play important roles in the initiation of numerous signal transduction pathways that are linked to apoptosis, ..
  32. Air pollution and the brain: gender as an important determinant of susceptibility
    Lucio G Costa; Fiscal Year: 2013
    ..PON2 levels are higher in females in all brain regions, and this confers some degree of resistance to oxidants. Preliminary findings in mice upon acute DE exposure are supportive of such hypothesis...
  33. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..Treatments with anti-oxidants, free radical scavengers, or angiotensin receptor blockers reduce CaOx crystal deposition in the kidneys of ..
  34. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
    ..To date, the dissection of the contribution of Nox2-derived ROS to oxidants generated by other sources has been complicated by the lack of good specific Nox2 inhibitors...
  35. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..Our studies seek to define age-related factors that enhance the severity of heart disease in an effort to design strategies to improve the outcome. ..
  36. Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration
    Goldis Malek; Fiscal Year: 2013
    ..We further propose that additional 'stressors'on the PPAR[unreadable]/d pathway (i.e., age, oxidants) lead to upregulation of these processes and further compromise RPE cell function, mediated by mitochondrial ..
  37. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2013
    ..of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  38. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Seattle-King
    PETER JAMES KUDENCHUK; Fiscal Year: 2013
    ..of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  39. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oxidants are widely regarded as molecules that contribute to chronic lung inflammation, and a direct role for oxidants in the activation of the transcription factor, Nuclear Factor kappa B, has been ..
  40. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Pittsburgh
    Clifton W Callaway; Fiscal Year: 2013
    ..of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion...
  41. Prostate Cancer Prevention by Diallyl Trisulfide
    Shivendra Singh; Fiscal Year: 2013
    ..chemopreventive regimens to eliminate potential adverse drug-drug interactions between DATS and other anti- oxidants or agents interfering with iron homeostasis...
  42. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2013
    ..These oxidants may trigger adaptive responses including the stabilization of Hypoxia-Inducible Factor-1 alpha (HIF-1a) and the ..
  43. Novel strategy to mitigate and treat radiation combined infection injury by targe
    Shyam Biswal; Fiscal Year: 2012
    ..factor-erythroid 2 p45-related factor 2 (NRF2) protects against inflammatory disorders caused by environmental oxidants and bacterial infection by inhibiting oxidative stress...
  44. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..We hypothesize that higher pO2 will be associated with depletion of anti- oxidants. Our third specific aim is to determine whether a non-invasive measure of corneal oxygen metabolism predicts ..
  45. BIOLOGICAL PROPERTIES OF RPE MELANIN
    Janice M Burke; Fiscal Year: 2010
    ..the responses of living RPE cells to lethal or sub-lethal oxidative stress induced by visible light or chemical oxidants. PUBLIC HEALTH RELEVANCE: RPE cells support the survival of retinal photoreceptors, but as RPE cells age they are ..
  46. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
    ..Soy isoflavones can also act as anti-oxidants in normal tissues thus protecting them from radiation-induced toxicity...
  47. Oxidative DNA damage processing;role in human pathology and aging
    PHILIP COURTLAND HANAWALT; Fiscal Year: 2013
    ..In support of this model we find that CS cells are hypersensitive to oxidants, and that UVSS but not CS cells are proficient in host cell reactivation of plasmids containing oxidized bases...
  48. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..elegans. Several long-lived mouse mutants are also resistant to multiple forms of stress, including oxidants, UV, and heavy metals. This relationship holds equally true for the exceptionally long-lived naked mole rat...
  49. ROS activation of Apoptosis Signal-regulated Kinase1 (Ask1) in chondrocytes
    Theresa Freeman; Fiscal Year: 2011
    ..Public Health Relevance: This proposal will examine the relationship between environmental oxidants and antioxidant expression in cartilage cells;how this balance affects cartilage cell function and cartilage ..
  50. Mechanisms Regulating Hemangioendothelioma: A Plastic Surgeon's Challenge
    Gayle M Gordillo; Fiscal Year: 2013
    ..cells that develop into tumors and to determine whether the biological products that result from nox-4 derived oxidants can be used as biomarkers...
  51. Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    Henry Jay Forman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We will investigate how oxidants and other electrophiles in cigarette smoke activate Src kinase, which precedes epithelial-mesenchymal transition (EMT)...
  52. The role of dinitrosyliron complexes in cancer etiology
    Douglas D Thomas; Fiscal Year: 2013
    ..These results will demonstrate the cytoprotective effects of NO against damage induced by chemical oxidants and oxidant-generating chemotherapeutic agents...
  53. Role and function of Spx paralogs of Bacillus anthracis
    PETER A ZUBER; Fiscal Year: 2012
    ..transcription and control of Spx stability is affected by changes in redox balance by treating cultures with oxidants known to induce Spx activity in B. subtilis...
  54. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..The oxidants appear to cause weakness since interventions that limit oxidant activity prevent loss of force...
  55. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    ..fumigatus conidia, and have been reported to produce oxidants to kill engaged pathogens. However, many details about the molecular mechanisms by which AM kill A...
  56. Role of Cholesterol in Age-related Decline in Steroidogenesis
    Salman Azhar; Fiscal Year: 2013
    ..monitoring changes in in vitro steroidogenesis, mRNA expression of StAR, PBR/TSPO and StarD proteins, levels of oxidants and markers of oxidative damage and the kinetics of hormone-induced cholesterol transport to mitochondria in ..
  57. Mitochondrial Dysfunction in Neurodegeneration of Aging
    Gary E Gibson; Fiscal Year: 2013
    ..rate limiting step for NADH formations, produces ROS, is obligatory for heme production, and is very sensitive to oxidants. TGase is a cross linking enzymes that can modulate transcription, inactivate metabolic enzymes, and cause ..
  58. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    ..In certain airway disorders, including those due to oxidants such as ozone, endogenous airway NEP activity is decreased...
  59. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  60. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  61. OXYGEN RADICALS, OXIDANTS AND MEMBRANE DYSFUNCTION
    RAKESH KUKREJA; Fiscal Year: 1990
    ..changes that occur in these organelles as a result of attack by oxygen free radicals and neutrophil derived oxidants. The specific aim of this project is to answer the following three hypotheses...
  62. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2[unreadable]>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-..
  63. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants will result in a decrease in anti-oxidant defense...
  64. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..The adverse molecular actions of oxidants have largely been attributed to their role in causing damage...
  65. Oxidant Stress: Is it a biomarker of disease progression and response to therapy
    Jesse Roman; Fiscal Year: 2010
    ..Several studies have demonstrated decreased levels of anti- oxidants in patients with IPF, and anti-oxidant strategies seem effective in animal models of lung fibrosis...
  66. A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitus
    Todd Perlstein; Fiscal Year: 2011
    ..Oxidative stress, defined as an excess of oxidants relative to antioxidants, in large part drives the vascular complications of T1DM...
  67. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2003
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  68. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  69. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2004
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...