oxidants

Summary

Summary: Oxidizing agents or electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). In vivo, it appears that phagocyte-generated oxidants function as tumor promoters or cocarcinogens rather than as complete carcinogens perhaps because of the high levels of endogenous antioxidant defenses. It is also thought that oxidative damage in joints may trigger the autoimmune response that characterizes the persistence of the rheumatoid disease process.

Top Publications

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
  3. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
  4. ncbi Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
  5. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
  6. ncbi Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
  7. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
  8. ncbi Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
  9. ncbi Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
  10. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998

Research Grants

  1. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Gary Bokoch; Fiscal Year: 2000
  2. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
  3. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
  4. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2009
  5. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2010
  6. DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUES
    YOGESH AWASTHI; Fiscal Year: 1990
  7. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
  8. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
  9. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
  10. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2010

Detail Information

Publications237 found, 100 shown here

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and ..
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  3. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
    ..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...
  4. ncbi Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
    ..Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role...
  5. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
    ..The antioxidant species help the lungs ward off the deleterious consequences of a wide variety of oxidants/reactive oxygen species such as superoxide anion, hydroxyl radical, hypohalite radical, hydrogen peroxide and ..
  6. ncbi Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
    ..and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently with thiols at rates that are closely related to their potencies...
  7. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    Exposure of cells to sublethal oxidative stress results in the modulation of various signaling pathways. Oxidants can activate and inactivate transcription factors, membrane channels, and metabolic enzymes, and regulate calcium-dependent ..
  8. ncbi Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ..NO2), formed as secondary products of (.)NO metabolism in the presence of oxidants including superoxide radicals (O2(.-)), hydrogen peroxide (H2O2), and transition metal centers...
  9. ncbi Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
    ..exacerbation, decrements in pulmonary function, and mortality underscores the important detrimental effects of oxidants on public health...
  10. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998
    ..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
  11. ncbi The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself
    I Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Free Radic Biol Med 31:1624-32. 2001
    ..Although the microfilament network is one of the earliest targets of oxidative stress, the mechanism by which oxidants change both the structure and the spatial organization of actin filaments is still a matter of debate and far ..
  12. ncbi Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
    Saul Soberanes
    Division of Pulmonary and Critical Care Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2176-86. 2009
    ..We conclude that particulate matter air pollution induces the generation of ROS primarily from site III of the mitochondrial electron transport chain and that these ROS activate the intrinsic apoptotic pathway through ASK1, JNK, and p53...
  13. ncbi NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    H Kono
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    J Clin Invest 106:867-72. 2000
    ..To test the hypothesis that NADPH oxidase is the major source of oxidants due to ethanol, we used p47(phox) knockout mice, which lack a critical subunit of this major source of reactive ..
  14. ncbi Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Nashville, Tennessee, USA
    J Clin Invest 111:583-93. 2003
  15. ncbi FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    Arunima Sengupta
    Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:7468-78. 2011
    ..These data support a critical role for FoxOs in promoting cardiomyocyte survival during conditions of oxidative stress through induction of antioxidants and cell survival pathways...
  16. ncbi The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants
    Angana Mukherjee
    Centre de Recherche en Infectiologie et Division de Microbiologie, Universite Laval, Quebec, Canada, G1V 4G2
    Mol Microbiol 74:914-27. 2009
    ..All phenotypes were reverted in the add-back mutant, thus proving the importance of thiols in dealing with oxidants including the action of antimonials.
  17. ncbi Subcellular targeting of oxidants during endothelial cell migration
    Ru Feng Wu
    University of Texas Southwestern, Dallas, TX 75390, USA
    J Cell Biol 171:893-904. 2005
    Endogenous oxidants participate in endothelial cell migration, suggesting that the enzymatic source of oxidants, like other proteins controlling cell migration, requires precise subcellular localization for spatial confinement of ..
  18. ncbi Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
    ..cells treated with H2O2 as well as growing under conditions known or suspected to affect the level of endogenous oxidants. Thirty- to 60-min exposure of cells to 100 or 200 microM H2O2 led to an increase in the level of H2AX ..
  19. ncbi Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
    Arvind Dasari
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:10805-14. 2006
    ..This study delineates for the first time the molecular mechanisms that modulate caveolin-1 gene transcription upon oxidative stress and brings new insights into the redox control of cellular senescence in both normal and cancer cells...
  20. ncbi The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
    ..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome...
  21. ncbi A caspase-related protease regulates apoptosis in yeast
    Frank Madeo
    Institute for Physiological Chemistry, University of Tubingen, Hoppe Seyler Strasse 4, 72076 Tubingen, Germany
    Mol Cell 9:911-7. 2002
    ..We conclude that Yor197w indeed functions as a bona fide caspase in yeast and propose the name Yeast Caspase-1 (YCA1, gene YCA1)...
  22. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..We have examined its reactivity with various biological oxidants, in order to assess its ability to act as a direct physiological target for these species...
  23. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  24. ncbi Oxidants/antioxidants and COPD
    W MacNee
    Edinburgh Lung Environmental Group Initiative, Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland, UK
    Chest 117:303S-17S. 2000
    Oxidative stress results from an oxidant/antioxidant imbalance, an excess of oxidants and/or a depletion of antioxidants...
  25. ncbi Effect of simulated microgravity on salivary and serum oxidants, antioxidants, and periodontal status
    Balwant Rai
    Oral Imaging Center, School of Dentistry, Oral Pathology, and Maxillofacial Surgery, Catholic University Leuven, Leuven, Belgium
    J Periodontol 82:1478-82. 2011
    ..The objective of the study is to determine the influence of simulated microgravity on the periodontal status and salivary and serum oxidant/antioxidant status of the body in simulated microgravity (-6° head-down-tilt [HDT) bed rest)...
  26. ncbi Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies
    R Beck
    Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Belgium
    Curr Med Chem 18:2816-25. 2011
    ..Overall, these results highlight the potential interest of using oxidative stress to target Hsp90...
  27. ncbi Quantification of protein modification by oxidants
    Clare L Hawkins
    The Heart Research Institute, Camperdown, NSW, Australia
    Free Radic Biol Med 46:965-88. 2009
    ..Exposure of proteins to these oxidants results in loss of the parent amino acid residue, formation of unstable intermediates, and the generation of ..
  28. ncbi Reactions of biological oxidants with selenourea: formation of redox active nanoselenium
    B Mishra
    Radiation Chemistry and Chemical Dynamics Division and Novel Materials and Structural Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
    J Phys Chem B 109:12718-23. 2005
    ..The studies demonstrate that selenourea undergoes oxidation with both one-electron and two-electron oxidants to produce elemental selenium, which, on stabilization to nanometer size, exhibits size-dependent redox activity.
  29. ncbi Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide
    Jane K Finzi
    , IB, UNICAMP, Campinas, SP, Brazil
    Mol Biochem Parasitol 133:37-43. 2004
    ..An increase in glucose-6-phosphate dehydrogenase activity was observed in pTEX-TcCPX epimastigotes that could provide cells with extra reducing power and a higher growth index...
  30. ncbi Alcohol, stroke and coronary heart disease. Are there anti-oxidants and pro-oxidants in alcoholic beverages that might influence the development of atherosclerotic cardiovascular disease?
    I B Puddey
    Department of Medicine and Western Australian Heart Research Institute, University of Western Australia, Perth, Australia
    Neuroepidemiology 18:292-302. 1999
    ..laboratory studies, the conclusion at present is that while we may continue to speculate that there are anti-oxidants and pro-oxidants in alcoholic beverages that influence the development of atherosclerotic cardiovascular disease, ..
  31. ncbi Oxidants, antioxidants and carcinogenesis
    Gibanananda Ray
    Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India
    Indian J Exp Biol 40:1213-32. 2002
    ..NO can stimulate O2*-/H2O2/*OH-induced LPO. These deleterious actions of oxidants can be countered by antioxidant defence system in humans...
  32. ncbi Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling
    Michel Rigoulet
    Universite Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell IBGC du CNRS, Bordeaux, France
    Antioxid Redox Signal 14:459-68. 2011
    ..The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed...
  33. ncbi Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP
    Shyra J Gardai
    Program in Cell Biology, The Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:44695-703. 2004
    ..in neutrophils is enhanced by "stress" stimuli such as tumor necrosis factor-alpha, Fas ligand, and oxidants, and this effect is inhibited by anti-apoptotic stimuli including granulocyte-macrophage colony-stimulating ..
  34. ncbi Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    Ernst Malle
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Biochim Biophys Acta 1761:392-415. 2006
    ..The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, ..
  35. ncbi Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing
    Christine C Winterbourn
    Department of Pathology, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 281:39860-9. 2006
    ..However, the role of oxidants in killing and the species responsible are poorly understood and the subject of current debate...
  36. ncbi The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study
    Ojia Skaff
    The Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, Sydney, NSW 2050, Australia
    Biochemistry 47:8237-45. 2008
    ....
  37. ncbi Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury
    Claudie M Hecquet
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA
    Thromb Haemost 101:619-25. 2009
    ..This review summarizes recent findings on the mechanism by which oxidants induce TRPM2 activation, the role of these channels in the signalling vascular endothelial dysfunctions, and the ..
  38. ncbi Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity
    H Maharaj
    Division of Pharmacology, Faculty of Pharmacy, Rhodes University, Grahamstown 6139, South Africa
    Metab Brain Dis 21:189-99. 2006
    ..In addition these agents inhibit the enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO), responsible for the synthesis of endogenous QA...
  39. ncbi The catalase and superoxide dismutase genes are transcriptionally up-regulated upon oxidative stress in the strictly anaerobic archaeon Methanosarcina barkeri
    Andrei L Brioukhanov
    Department of Microbiology, Biological Faculty, Lomonosov Moscow State University, Vorob evy Hills 1 12, 119992 Moscow, Russia
    Microbiology 152:1671-7. 2006
    ..PQ and to a lesser degree H2O2 induced the expression of superoxide dismutase. The results indicate the regulation of the adaptive response of M. barkeri to different oxidative stresses...
  40. ncbi Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation
    Jonathan P Brennan
    Department of Cardiology, King's College London, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH United Kingdom
    J Biol Chem 281:21827-36. 2006
    ..In essence, type I PKA contains protein thiols that operate as redox sensors, and their oxidation by hydrogen peroxide directly activates the kinase...
  41. ncbi Role of oxidants in lung injury during sepsis
    Ren Feng Guo
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Antioxid Redox Signal 9:1991-2002. 2007
    ..However, the results are inconclusive. In this article, we focus on the current understanding of the pathogenesis of sepsis-induced ALI and novel antioxidant strategies for therapeutic purposes...
  42. ncbi Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    D K Kaul
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 106:411-20. 2000
    ..These findings suggest that leukocyte-endothelium interaction contribute to vasoocclusive events in the sickle mice and perhaps in human sickle disease...
  43. ncbi Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling
    Quentin Felty
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Oncogene 24:4883-93. 2005
    ..Thus, our results suggest (1) a new paradigm that estrogen-induced mitochondrial oxidants control the early stage of cell cycle progression and (2) provide the basis for the discovery of novel ..
  44. ncbi Characterization of the SKN7 ortholog of Aspergillus fumigatus
    Claude Lamarre
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Cedex 15, France
    Fungal Genet Biol 44:682-90. 2007
    ..This result indicated that an increased sensitivity of A. fumigatus to peroxides in vitro is not correlated with a modification of fungal virulence...
  45. ncbi Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase
    Beatrix A Olofsson
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Mol Cancer Res 5:1319-30. 2007
    ..Together, these data show that Sp1 is a novel ATM substrate that plays a role in the cellular response to DNA damage...
  46. ncbi Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants
    Hajo Haase
    Institute of Immunology, University Hospital RWTH Aachen, Germany
    Biometals 18:333-8. 2005
    ..Zinc deficiency activates stress pathways and may result in a loss of tyrosine phosphatase control, thereby causing insulin resistance...
  47. ncbi Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    S L Hempel
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Free Radic Biol Med 27:146-59. 1999
    ..tests the hypothesis that dihydrofluorescein diacetate is a better fluorescent probe for detecting intracellular oxidants because it is more reactive toward specific oxidizing species...
  48. ncbi Cells deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to oxidants with increased G2/M arrest and multinucleation
    Yali Xie
    Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, MB R3E 0W9, Canada
    Carcinogenesis 29:722-8. 2008
    ..Myh and Ogg1 double knockout cells were more sensitive than wild type to oxidants (hydrogen peroxide and t-butyl hydroperoxide), but not to cis-platinum or gamma-irradiations...
  49. ncbi Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan
    Martin D Rees
    The Heart Research Institute, 114 Pyrmont Bridge Rd Camperdown, Sydney NSW, Australia
    Matrix Biol 29:63-73. 2010
    The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes...
  50. ncbi Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:1940-5. 2006
    ..live cells undergoes continuous oxidative damage caused by metabolically generated endogenous as well as external oxidants and oxidant-inducers...
  51. ncbi Oxidant-dependent switching between reversible and sacrificial oxidation pathways for Bacillus subtilis OhrR
    Sumarin Soonsanga
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    Mol Microbiol 68:978-86. 2008
    ..Thus, depending on the oxidant, OhrR can be either reversibly oxidized or can instead function as a sacrificial regulator...
  52. ncbi Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
    Antioxid Redox Signal 10:739-53. 2008
    ..This review summarizes the recent progress concerning how redox status can be modulated and how it regulates gene transcription during the development of ARDS, as well as the therapeutic implications...
  53. ncbi Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1117-29. 2003
    ..In addition to their capacity to damage macromolecules, oxidants play important roles in the initiation of numerous signal transduction pathways that are linked to apoptosis, ..
  54. ncbi Advanced glycation end products and cardiovascular disease
    Melpomeni Peppa
    Endocrine Unit, 2nd Department of Internal Medicine Propaedeutic, Research Institute and Diabetes Center, Attikon University Hospital, Athens, Greece
    Curr Diabetes Rev 4:92-100. 2008
    ..Recent in vitro and in vivo studies revealed significant correlations between diet-derived AGEs and several risk factors and/or markers of CVD, suggesting the dietary AGEs restriction as a promising therapeutic intervention...
  55. ncbi Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases
    D I Pattison
    The Heart Research Institute, 114 Pyrmont Bridge Rd, Camperdown, Sydney, NSW 2050, Australia
    Curr Med Chem 13:3271-90. 2006
    ..A key function of MPO is the production of hypohalous acids (HOX, X = Cl, Br) which are strong oxidants with potent antibacterial properties...
  56. ncbi SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    Samuel Caito
    Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    FASEB J 24:3145-59. 2010
    ..b>Oxidants, aldehydes, and CS induced carbonyl modifications on SIRT1 on cysteine residues concomitant with decreased SIRT1 ..
  57. ncbi Oxidants in the gas phase of cigarette smoke pass through the lung alveolar wall and raise systemic oxidative stress
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Kyuban cho, Nishinomiya, Japan
    J Pharmacol Sci 103:275-82. 2007
    ..Aqueous cigarette smoke extract (CSE) contains stable oxidants, peroxynitrite-like reactants, which have the ability to oxidize and nitrate low-density lipoprotein (LDL)...
  58. ncbi Distinct overexpression of cytosolic and mitochondrial tryparedoxin peroxidases results in preferential detoxification of different oxidants in arsenite-resistant Leishmania amazonensis with and without DNA amplification
    Yi-Chun Lin
    Division of Infectious Diseases, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, ROC
    Mol Biochem Parasitol 142:66-75. 2005
    ..The decreased expression was followed by increased sensitivity of these transfectants to the oxidants. This possibly is due to the formation of antisense mRNA in these transfectants that causes a specific ..
  59. ncbi Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta
    T H Hung
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei 105, Taiwan
    Placenta 29:565-83. 2008
    ..We surmised that hypoxia-reoxygenation (HR) is the mechanism and hypothesized that mitochondrial oxidants and Bcl-2 proteins cause HR-induced placental apoptosis...
  60. ncbi Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Free Radic Biol Med 49:1273-82. 2010
    ..RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney...
  61. ncbi Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, University of Chicago, Chicago, IL, USA
    Am J Physiol Heart Circ Physiol 298:H2164-73. 2010
    ..We conclude that TH cardioprotection is mediated by enhanced Akt/HSP27 phosphorylation and enhanced NO generation, resulting in the attenuation of ROS generation and the maintenance of DeltaPsim following ischemia-reperfusion...
  62. ncbi ABC transporters affect the detection of intracellular oxidants by fluorescent probes
    Jirina Prochazkova
    Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Free Radic Res 45:779-87. 2011
    ..The activity of these transporters must be considered when employing fluorescent probes for the assessment of ROS production or mitochondrial membrane potential...
  63. ncbi Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest
    Sebastián Carballal
    Laboratorio De Enzimologia, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay
    Free Radic Biol Med 50:196-205. 2011
    ..possible antioxidant role, we investigated the reactivity of hydrogen sulfide with several one- and two-electron oxidants. The rate constant of the direct reaction with peroxynitrite was (4.8±1.4)×10(3)M(-1) s(-1) (pH 7.4, 37°C)...
  64. ncbi Oxidative stress triggers thiol oxidation in the glyceraldehyde-3-phosphate dehydrogenase of Staphylococcus aureus
    Harald Weber
    , , Jahnstrasse 15, 17487 Greifswald, Germany
    Mol Microbiol 52:133-40. 2004
    ..Our data indicate that the damaged Gap protein was not repaired...
  65. ncbi Markers of protein oxidation: different oxidants give rise to variable yields of bound and released carbonyl products
    Henrietta A Headlam
    Free Radical Group, Heart Research Institute, Camperdown, Sydney, Australia
    Free Radic Biol Med 36:1175-84. 2004
    ..We now show that this is a general mechanism that occurs with a wide range of oxidants. The quantitative significance of this process depends on the extent of oxidation at C-3 compared with other ..
  66. ncbi Reactivity patterns of cytochrome P450 enzymes: multifunctionality of the active species, and the two states-two oxidants conundrum
    Sason Shaik
    Department of Organic Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
    Nat Prod Rep 24:533-52. 2007
  67. ncbi Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants
    Susanta Kar
    Molecular Cell Biology Laboratory, Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    J Antimicrob Chemother 66:618-25. 2011
    ....
  68. ncbi Oxidants act as chemorepellents in Paramecium by stimulating an electrogenic plasma membrane reductase activity
    T M Hennessey
    Department of Biological Sciences State University of New York at Buffalo 14260
    J Comp Physiol A 175:655-65. 1994
    ..While millimolar amounts of many attractants hyperpolarize and cause faster forward swimming, oxidants are repellents that depolarize and cause backward swimming at micromolar concentrations...
  69. ncbi Effects of various oxidants and antioxidants on the p38-MAPK signalling pathway in the perfused amphibian heart
    Catherine Gaitanaki
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens, 157 84, Greece
    Mol Cell Biochem 291:107-17. 2006
    ..14 +/- 0.27-fold) and HSP27 (5.32 +/- 0.83-fold), which are implicated in cell protection, and this activation was reduced by the simultaneous use of catalase and SOD...
  70. ncbi Critical role of the atypical {lambda} isoform of protein kinase C (PKC-{lambda}) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium
    A Banan
    Section of Gastroenterology and Nutrition, Rush University of Chicago, College of Medicine, Division of Digestive Diseases, 1725 W Harrison, Suite 206, Chicago, IL 60612, USA
    J Pharmacol Exp Ther 312:458-71. 2005
    ..Studying monolayers of intestinal (Caco-2) cells, we reported that oxidants disrupt the cytoskeleton and cause barrier dysfunction (hyperpermeability)...
  71. ncbi Hypertension, nitric oxide, oxidants, and dietary plant polyphenols
    Monica Galleano
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956 C1113AAD, Buenos Aires, Argentina
    Curr Pharm Biotechnol 11:837-48. 2010
    ....
  72. ncbi Oxidants and antioxidants in sulfur mustard-induced injury
    Jeffrey D Laskin
    Department of Environmental and Occupation Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:92-100. 2010
    ..These data indicate that drugs that target oxidative stress pathways may represent important candidates for reducing SM-induced tissue injury...
  73. ncbi Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants
    Rosaria Piga
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Neurotoxicology 28:67-75. 2007
    ..These results suggest that the involvement of ROS and the protective effect of antioxidants depend on the type of stressors...
  74. ncbi Oxidants in signal transduction: impact on DNA integrity and gene expression
    Kathryn A Ziel
    University of South Alabama College of Medicine, Department of Pharmacology and Center for Lung Biology, Mobile, AL 36688, USA
    FASEB J 19:387-94. 2005
    ..b>Oxidants generated in the context of physiological signaling thus affect nuclear DNA integrity and may facilitate gene ..
  75. ncbi Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage
    Alejandra G Erlejman
    IQUIFIB-Department of Biological Chemistry (UBA-CONICET, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Free Radic Biol Med 41:1247-56. 2006
    ..DOC induced an increase in cell oxidants, alterations in the paracellular transport, and redistribution of the protein ZO-1 from cell-cell contacts into ..
  76. ncbi Cellular response to cigarette smoke and oxidants: adapting to survive
    André M Cantin
    Pulmonary Division, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue N, Sherbrooke, PQ, J1H 5N4 Canada
    Proc Am Thorac Soc 7:368-75. 2010
    The gaseous and soluble phases of cigarette smoke are sources of oxidants that contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD)...
  77. ncbi Gamma globulin, Evan's blue, aprotinin A PLA2 inhibitor, tetracycline and antioxidants protect epithelial cells against damage induced by synergism among streptococcal hemolysins, oxidants and proteinases: relation to the prevention of post-streptococcal
    I Ginsburg
    Department of Oral Biology, Hebrew University Hadassah, School of Dental Medicine, Jerusalem, Israel
    FEMS Immunol Med Microbiol 22:247-56. 1998
    ..However very strong toxic effects were induced when EXP was combined with oxidants (glucose oxides generated H2O2, AAPH-induced peroxyl radical (ROO...
  78. ncbi Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function
    Rüdiger Siekmeier
    Federal Institute for Drugs and Medical Devices Bonn, Germany
    J Cardiovasc Pharmacol Ther 13:279-97. 2008
    ....
  79. ncbi Evidence that nuclear factor-kappa B activation is critical in oxidant-induced disruption of the microtubule cytoskeleton and barrier integrity and that its inactivation is essential in epidermal growth factor-mediated protection of the monolayers of inte
    A Banan
    Department of Internal Medicine, Section of Gastroenterology and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Pharmacol Exp Ther 306:13-28. 2003
    Using monolayers of intestinal (Caco-2) cells, we showed that oxidants disrupt the microtubule cytoskeleton and barrier integrity; epidermal growth factor (EGF) was protective via stabilization of the microtubules...
  80. ncbi Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells
    Annika Höhn
    Institute of Biological Chemistry and Nutrition, Department of Biofunctionality and Food Safety, University of Hohenheim, 70593 Stuttgart, Germany
    Free Radic Biol Med 48:1100-8. 2010
    ..In this study for the first time the lipofuscin-mediated formation of oxidants and the role of iron in this process are directly shown in a model of senescent fibroblasts, as well as in vitro ..
  81. ncbi Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions
    J Richard Wagner
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Acc Chem Res 43:564-71. 2010
    ..The data and insights presented here shed new light on oxidation reactions of cytosine and 5-methylcytosine and should facilitate their validation in cellular DNA...
  82. ncbi Trends in substrate hydroxylation reactions by heme and nonheme iron(IV)-oxo oxidants give correlations between intrinsic properties of the oxidant with barrier height
    Sam P de Visser
    Manchester Interdisciplinary Biocenter and School of Chemical Engineering and Analytical Science, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    J Am Chem Soc 132:1087-97. 2010
    Iron(IV)-oxo species have been characterized in several nonheme enzymes and biomimetic systems and are efficient oxidants of aliphatic hydroxylation reactions...
  83. ncbi Response to different oxidants of Saccharomyces cerevisiae ure2Delta mutant
    Tatina T Todorova
    University of Strasbourg UMR 7156 CNRS, 28 rue Goethe, 67083 Strasbourg Cedex, France
    Arch Microbiol 191:837-45. 2009
    ..A time-dependent increase in SOD and catalase activity was observed. More importantly, it was shown that the ure2 mutation could cause significant disturbance in cellular oxidant balance and increased ROS level...
  84. ncbi Resistance of melanized yeast cells of Paracoccidioides brasiliensis to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18
    Marcelo Barbosa da Silva
    Departamento de Microbiologia, Laboratório de Micologia Médica LIM53 Hospital de Clínicas, Faculdade de Medicina, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brasil
    Mem Inst Oswaldo Cruz 104:644-8. 2009
    ..Intratracheal infection of BALB/c mice, with melanized yeast cells, resulted in higher lung colony forming units, when compared to nonmelanized yeast cells. Therefore, melanin is a virulence factor of P. brasiliensis...
  85. ncbi The effect of electrode material on the generation of oxidants and microbial inactivation in the electrochemical disinfection processes
    Joonseon Jeong
    Urban Water Research Center, Department of Civil and Environmental Engineering, University of California, Irvine, Irvine, CA 92697 2175, USA
    Water Res 43:895-901. 2009
    ..The most common method of electrochemical disinfection is the use of electro-generated oxidants, such as active chlorine and reactive oxygen species, as disinfectants...
  86. ncbi Enhanced formation of oxidants from bimetallic nickel-iron nanoparticles in the presence of oxygen
    Changha Lee
    Department of Civil and Environmental Engineering, 657 Davis Hall, University of California, Berkeley, California 94720, USA
    Environ Sci Technol 42:8528-33. 2008
    Nanoparticulate zero-valent iron (nZVI) rapidly reacts with oxygen to produce strong oxidants capable of transforming organic contaminants in water...
  87. ncbi Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants
    Bruno Burlando
    Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale Amedeo Avogadro, Corso Borsalino 54, 15100 Alessandria, Italy
    Cell Physiol Biochem 13:147-54. 2003
    ..We studied the effects of heavy metals and pro-oxidants on tyrosine kinase signalling in trout hepatoma cells (RTH 149) by Western immunoblotting...
  88. ncbi Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
    Moon Il Kang
    Center for Tsukuba Advanced Research Alliance and Japan Science and Technology Agency Exploratory Research for Advanced Technology Environmental Response Project, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Proc Natl Acad Sci U S A 101:2046-51. 2004
    ..inducible expression of phase 2 proteins that protect animal cells against the toxic effects of electrophiles and oxidants. Under basal conditions, Nrf2 is sequestered in the cytoplasm by Keap1, a multidomain, cysteinerich protein that ..
  89. ncbi What factors influence the rate constant of substrate epoxidation by compound I of cytochrome P450 and analogous iron(IV)-oxo oxidants?
    Devesh Kumar
    Molecular Modelling Group, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    J Am Chem Soc 132:7656-67. 2010
    ..found a correlation for substrate epoxidation reactions catalyzed by a range of heme and nonheme iron(IV)-oxo oxidants with the strength of the O-H bond in the iron-hydroxo complex, i.e. BDE(OH), which is supported by the VB model...
  90. ncbi Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
    Viviana Montecinos
    Departamento de Fisiopatologia, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160C, Concepcion, Chile
    J Biol Chem 282:15506-15. 2007
    ..Therefore, in endothelial cells under oxidative challenge, vitamin C functions as an essential cellular antioxidant even in the presence of a vast molar excess of glutathione...
  91. ncbi Peroxide-induced cell death and lipid peroxidation in C6 glioma cells
    Arne Linden
    Institute for Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse 10, 24105 Kiel, Germany
    Toxicol In Vitro 22:1371-6. 2008
    ..The results strongly indicate a major role of lipid peroxidation in the killing of C6 cells by organic peroxides but also that lipid peroxidation is not involved in H2O2 induced cell death...
  92. ncbi SNAP25 is a pre-synaptic target for the depressant action of reactive oxygen species on transmitter release
    A R Giniatullin
    Kazan Medical University, Tatarstan, Russia
    J Neurochem 98:1789-97. 2006
    ..This mechanism of ROS signalling could have widespread implications in the nervous system and might contribute to the pathogenesis of neurodegenerative diseases...
  93. ncbi DNA damage, RAD9 and fertility/infertility of Echinococcus granulosus hydatid cysts
    Gonzalo Cabrera
    Programa Disciplinario de Biología Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 216:498-506. 2008
    ..Our results suggest that molecules involved in DNA repair in the germinal layer of fertile hydatid cysts and in protoscoleces, such as EgRAD9, may allow preserving the fertility of hydatid cysts in the presence of ROS and RNS...
  94. ncbi Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins
    Ting Wang
    State Key Laboratory of Applied Organic Chemistry, and Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
    Can J Physiol Pharmacol 86:279-87. 2008
    ....
  95. ncbi The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death
    A Banjac
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut für Klinische Molekularbiologie und Tumorgenetik, Munchen, Germany
    Oncogene 27:1618-28. 2008
    ..Our findings show that the cystine/cysteine redox cycle by itself must be viewed as a discrete major regulator of cell survival...
  96. ncbi The overexpression of NADPH-producing enzymes counters the oxidative stress evoked by gallium, an iron mimetic
    R Beriault
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, P3E 2C6, Canada
    Biometals 20:165-76. 2007
    ..Fe metabolism appeared to be severely impeded by Ga toxicity. This is the first demonstration of the oxidative stress evoked by Ga to be neutralized by a reductive environment generated via the overexpression of NADPH-producing enzymes...
  97. ncbi Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes
    Y Shi
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Br J Pharmacol 152:1033-41. 2007
    ..The present experiments were designed to study the contribution of oxygen-derived free radicals to endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes...
  98. ncbi Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1
    Kana Nunome
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biol Pharm Bull 31:1321-6. 2008
    ..Therefore, the neuroprotective effects of PQQ on oxidative stress-induced neuronal death may be at least in part involved in increased level of an active form of DJ-1...
  99. ncbi Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures
    Jing Bi
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, PR China
    Neurosci Lett 442:224-7. 2008
    ..Therefore, catalpol may be developed as a potential preventive or therapeutic drug for neurodegenerative diseases associated with oxidative stress...
  100. ncbi Antioxidant properties of argpyrimidine
    Nair Sreejayan
    Division of Pharmaceutical Sciences, School of Pharmacy, College of Health Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Eur J Pharmacol 593:30-5. 2008
    ..Taken together, our data suggest that argpyrimidine has antioxidant properties and may therefore have biological relevance in pathophysiologies associated with diabetes mellitus and neurodegenerative diseases...
  101. ncbi Influence of naringin on ferric iron induced oxidative damage in vitro
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576104, India
    Clin Chim Acta 347:189-97. 2004
    ..It may become toxic when not handled carefully by cellular proteins and shielded from surrounding media. Naringin treatment may help to overcome the iron-induced toxic effects in vitro...

Research Grants77

  1. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Gary Bokoch; Fiscal Year: 2000
    ..Abstract) The NADPH oxidase of human phagocytes is responsible for the formation of superoxide anion and other oxidants used by these cells for bacterial killing, and is also an important component of the inflammatory response...
  2. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  3. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  4. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2009
    ..of EO peroxidase (EPO) and a vigorous respiratory burst that generates H2O2 to fuel the generation of other oxidants. However, little is known about the contribution of EPO-mediated oxidative damage to the pathology of ..
  5. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2010
    ..of EO peroxidase (EPO) and a vigorous respiratory burst that generates H2O2 to fuel the generation of other oxidants. However, little is known about the contribution of EPO-mediated oxidative damage to the pathology of ..
  6. DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUES
    YOGESH AWASTHI; Fiscal Year: 1990
    ..GSH) plays an important role in protecting the ocular tissues from the oxidative stress due to endogenous oxidants, as well as from the environmental pollutants, and xenobiotics...
  7. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  8. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
    The decision between death or survival of lung epithelial cells exposed to oxidants is regulated by multiple signaling pathways...
  9. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants will result in a decrease in anti-oxidant defense...
  10. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2010
    ..We previously hypothesized that anti- oxidants, such as N-acetylcysteine or vitamin C, decrease tumorigenesis by interfering with genomic instability by ..
  11. Oxidant Stress: Is it a biomarker of disease progression and response to therapy
    Jesse Roman; Fiscal Year: 2010
    ..Several studies have demonstrated decreased levels of anti- oxidants in patients with IPF, and anti-oxidant strategies seem effective in animal models of lung fibrosis...
  12. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2005
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  13. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  14. EFFECTS OF ETHANOL AND ACETALDEHYDE ON LIVER FUNCTION
    Arthur Cederbaum; Fiscal Year: 1993
    ..of ferritin to catalyze NADH- and NADPH-dependent generation of active oxygen radicals and interact with pro-oxidants will be determined...
  15. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2003
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  16. Mechanisms of Embryo Response to Oxidative Stress
    Mark E Hahn; Fiscal Year: 2010
    ..The expression and inducibility of anti-oxidant defenses are critical factors affecting susceptibility to oxidants at these early life stages, but the ontogenic development of these responses in embryos is not well understood...
  17. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  18. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2004
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...