oxidants

Summary

Summary: Oxidizing agents or electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). In vivo, it appears that phagocyte-generated oxidants function as tumor promoters or cocarcinogens rather than as complete carcinogens perhaps because of the high levels of endogenous antioxidant defenses. It is also thought that oxidative damage in joints may trigger the autoimmune response that characterizes the persistence of the rheumatoid disease process.

Top Publications

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
  3. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
  4. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
  5. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
  6. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
  7. ncbi Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators
    Colette T Dooley
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093 0647, USA
    J Biol Chem 279:22284-93. 2004
  8. pmc Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, University of Chicago, Chicago, IL, USA
    Am J Physiol Heart Circ Physiol 298:H2164-73. 2010
  9. ncbi The role of oxidants and free radicals in reperfusion injury
    Jay L Zweier
    Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
    Cardiovasc Res 70:181-90. 2006
  10. pmc Signal transduction by mitochondrial oxidants
    Toren Finkel
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4434-40. 2012

Detail Information

Publications278 found, 100 shown here

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and ..
  2. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  3. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
    ..and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently with thiols at rates that are closely related to their potencies...
  4. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
    ..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...
  5. ncbi Oxidant and antioxidant balance in the airways and airway diseases
    Irfan Rahman
    Department of Environmental Medicine, Division of Lung Biology and Disease, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    Eur J Pharmacol 533:222-39. 2006
    ..The antioxidant species help the lungs ward off the deleterious consequences of a wide variety of oxidants/reactive oxygen species such as superoxide anion, hydroxyl radical, hypohalite radical, hydrogen peroxide and ..
  6. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ..NO2), formed as secondary products of (.)NO metabolism in the presence of oxidants including superoxide radicals (O2(.-)), hydrogen peroxide (H2O2), and transition metal centers...
  7. ncbi Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators
    Colette T Dooley
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093 0647, USA
    J Biol Chem 279:22284-93. 2004
    ..C48S, S147C, and Q204C) and roGFP2 (the same plus S65T) with physiologically or toxicologically relevant oxidants both in vitro and in living mammalian cells...
  8. pmc Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, Emergency Resuscitation Center, University of Chicago, Chicago, IL, USA
    Am J Physiol Heart Circ Physiol 298:H2164-73. 2010
    ..We conclude that TH cardioprotection is mediated by enhanced Akt/HSP27 phosphorylation and enhanced NO generation, resulting in the attenuation of ROS generation and the maintenance of DeltaPsim following ischemia-reperfusion...
  9. ncbi The role of oxidants and free radicals in reperfusion injury
    Jay L Zweier
    Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
    Cardiovasc Res 70:181-90. 2006
    ..NO and peroxynitrite can inhibit pathways of oxygen radical generation, and, in turn, oxidants can inhibit NO synthesis from NOS...
  10. pmc Signal transduction by mitochondrial oxidants
    Toren Finkel
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4434-40. 2012
    ..Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules...
  11. ncbi Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    J P Eiserich
    Department of Internal Medicine, University of California, Davis 95616, USA
    Nature 391:393-7. 1998
    ..Our data reveal that NO2- may regulate inflammatory processes through oxidative mechanisms, perhaps by contributing to the tyrosine nitration and chlorination observed in vivo...
  12. ncbi The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself
    I Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Free Radic Biol Med 31:1624-32. 2001
    ..Although the microfilament network is one of the earliest targets of oxidative stress, the mechanism by which oxidants change both the structure and the spatial organization of actin filaments is still a matter of debate and far ..
  13. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..We have examined its reactivity with various biological oxidants, in order to assess its ability to act as a direct physiological target for these species...
  14. pmc Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Nashville, Tennessee, USA
    J Clin Invest 111:583-93. 2003
  15. pmc Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
    Saul Soberanes
    Division of Pulmonary and Critical Care Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2176-86. 2009
    ..We conclude that particulate matter air pollution induces the generation of ROS primarily from site III of the mitochondrial electron transport chain and that these ROS activate the intrinsic apoptotic pathway through ASK1, JNK, and p53...
  16. pmc NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    H Kono
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
    J Clin Invest 106:867-72. 2000
    ..To test the hypothesis that NADPH oxidase is the major source of oxidants due to ethanol, we used p47(phox) knockout mice, which lack a critical subunit of this major source of reactive ..
  17. doi Microbial and host cells acquire enhanced oxidant-scavenging abilities by binding polyphenols
    Isaac Ginsburg
    The Faculty of Dental Medicine, Institute for Dental Sciences, Hebrew University, Hadassah Medical Center, P O Box 12065, Jerusalem 91120, Israel
    Arch Biochem Biophys 506:12-23. 2011
    ..cavity, metabolized polyphenols might be beneficial in the gastrointestinal tract to counteract the toxicity of oxidants and also of the sequelae of inflammatory processes...
  18. ncbi Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
    Erez Koren
    Department of Pharmaceutics, School of Pharmacy, Hadassah Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Exp Biol Med (Maywood) 235:689-99. 2010
    ..Further studies are needed to determine the faith of polyphenols in the circulation and their sequestration in the spleen...
  19. ncbi Cancer cell killing via ROS: to increase or decrease, that is the question
    Jie Wang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:1875-84. 2008
    ..In clinical setting individualized choice of an optimal ROS-manipulation therapy may require accurate and convenient measurements for ROS as well as "redox signaling signature" for prediction of efficacy and systemic toxicity...
  20. pmc Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species
    Elisa Couto Gomes
    Department of Biochemistry and Immunology, Institute of Biological Science, Federal University of Minas Gerais UFMG, Belo Horizonte, MG, Brazil
    Oxid Med Cell Longev 2012:756132. 2012
    ..This is a new area of study that promises important findings in the sphere of molecular and cellular mechanisms involved in the relationship between oxidative stress and exercise...
  21. ncbi Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins
    Samuel M S Cheung
    Department of Immunology, University of Manitoba, 730 William Avenue, Winnipeg, MB Canada R3E 0W3
    Cell Signal 19:902-12. 2007
    ..Our results indicate that exogenous and endogenous superoxides can modulate the quality of the PI3K signal in lymphocytes by selectively increasing PI(3,4)P2-dependant signaling...
  22. ncbi Interactions of oxidants with vascular signaling systems
    M S Wolin
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Arterioscler Thromb Vasc Biol 20:1430-42. 2000
    ....
  23. doi Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest
    Sebastián Carballal
    Laboratorio De Enzimologia, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay
    Free Radic Biol Med 50:196-205. 2011
    ..possible antioxidant role, we investigated the reactivity of hydrogen sulfide with several one- and two-electron oxidants. The rate constant of the direct reaction with peroxynitrite was (4.8±1.4)×10(3)M(-1) s(-1) (pH 7.4, 37°C)...
  24. pmc Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction
    Chunhua Cao
    Div of Nephrology, N3W143, 22 S Greene St, UMMS, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 299:F1056-64. 2010
    ..Intrinsic NO production does not affect DVR permeability to hydrophilic solutes...
  25. pmc FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    Arunima Sengupta
    Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:7468-78. 2011
    ..These data support a critical role for FoxOs in promoting cardiomyocyte survival during conditions of oxidative stress through induction of antioxidants and cell survival pathways...
  26. ncbi Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  27. ncbi Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD
    Diego G Espinosa-Heidmann
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 47:729-37. 2006
    ..This study was an investigation of the effects of cigarette smoke (CS) and HQ in the development of sub-RPE deposits in an experimental mouse model...
  28. ncbi Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants
    Hajo Haase
    Institute of Immunology, University Hospital RWTH Aachen, Germany
    Biometals 18:333-8. 2005
    ..Zinc deficiency activates stress pathways and may result in a loss of tyrosine phosphatase control, thereby causing insulin resistance...
  29. ncbi Oxidants, antioxidants and carcinogenesis
    Gibanananda Ray
    Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India
    Indian J Exp Biol 40:1213-32. 2002
    ..NO can stimulate O2*-/H2O2/*OH-induced LPO. These deleterious actions of oxidants can be countered by antioxidant defence system in humans...
  30. pmc Hydrogen peroxide as a signal controlling plant programmed cell death
    Tsanko S Gechev
    Department Molecular Biology of Plants, Researchschool GBB, University of Groningen, 9751 NN, Haren, Netherlands
    J Cell Biol 168:17-20. 2005
    ..This review also describes a novel link between H2O2 and sphingolipids, two signals that can interplay and regulate plant cell death...
  31. ncbi A novel assay for replicative lifespan in Saccharomyces cerevisiae
    Stefanie Jarolim
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria
    FEMS Yeast Res 5:169-77. 2004
    ..for assaying replicative lifespan in yeast, and apply it in a screening of mutants that are resistant to pro-oxidants. The assay reproduces the lifespan-shortening effects of deleting SIR2 and of growth in the presence of paraquat, ..
  32. pmc Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense
    Jacob M Rothfork
    Research Service, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    Proc Natl Acad Sci U S A 101:13867-72. 2004
    ..Here, we show that phagocyte-derived oxidants target these autoinducers for inactivation as an innate defense mechanism of the host...
  33. doi Effects of chronic mild stress on the oxidative parameters in the rat brain
    Giancarlo Lucca
    Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Universidade do Extremo Sul Catarinense, Criciuma, Criciuma, SC, Brazil
    Neurochem Int 54:358-62. 2009
    ..In conclusion, our results support the idea that stress produces oxidants and an imbalance between superoxide dismutase and catalase activities that contributes to stress-related diseases,..
  34. pmc Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide
    Marco Palma
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Bacteriol 186:248-52. 2004
    Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls...
  35. ncbi Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements
    Arvind Dasari
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:10805-14. 2006
    ..This study delineates for the first time the molecular mechanisms that modulate caveolin-1 gene transcription upon oxidative stress and brings new insights into the redox control of cellular senescence in both normal and cancer cells...
  36. ncbi The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
    ..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome...
  37. pmc Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
    ..cells treated with H2O2 as well as growing under conditions known or suspected to affect the level of endogenous oxidants. Thirty- to 60-min exposure of cells to 100 or 200 microM H2O2 led to an increase in the level of H2AX ..
  38. ncbi The antioxidant role of coenzyme Q
    Magnus Bentinger
    Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden
    Mitochondrion 7:S41-50. 2007
    ..An increase in CoQ concentration in specific cellular compartments in the presence of various types of oxidative stress appears to be of considerable interest...
  39. doi Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
    Antioxid Redox Signal 10:739-53. 2008
    ..This review summarizes the recent progress concerning how redox status can be modulated and how it regulates gene transcription during the development of ARDS, as well as the therapeutic implications...
  40. pmc Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
    Maddalena Fratelli
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 99:3505-10. 2002
    ..To this purpose, we radiolabeled cellular glutathione with (35)S, exposed T cells to oxidants (diamide or hydrogen peroxide), and performed nonreducing, two-dimensional electrophoresis followed by detection ..
  41. pmc Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
    Timothy J Harrigan
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 106:2449-62. 2008
    ..Taken together, these data suggest that the anion channel VRAC may contribute to microglial glutamate release and that its activity is regulated by endogenous ROS originating from NOX4...
  42. ncbi A caspase-related protease regulates apoptosis in yeast
    Frank Madeo
    Institute for Physiological Chemistry, University of Tubingen, Hoppe Seyler Strasse 4, 72076 Tubingen, Germany
    Mol Cell 9:911-7. 2002
    ..We conclude that Yor197w indeed functions as a bona fide caspase in yeast and propose the name Yeast Caspase-1 (YCA1, gene YCA1)...
  43. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  44. ncbi Oxidants/antioxidants and COPD
    W MacNee
    Edinburgh Lung Environmental Group Initiative, Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland, UK
    Chest 117:303S-17S. 2000
    Oxidative stress results from an oxidant/antioxidant imbalance, an excess of oxidants and/or a depletion of antioxidants...
  45. doi The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants
    Angana Mukherjee
    Centre de Recherche en Infectiologie et Division de Microbiologie, Universite Laval, Quebec, Canada, G1V 4G2
    Mol Microbiol 74:914-27. 2009
    ..All phenotypes were reverted in the add-back mutant, thus proving the importance of thiols in dealing with oxidants including the action of antimonials.
  46. ncbi Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation
    Jonathan P Brennan
    Department of Cardiology, King s College London, The Rayne Institute, St Thomas Hospital, London, SE1 7EH United Kingdom
    J Biol Chem 281:21827-36. 2006
    ..In essence, type I PKA contains protein thiols that operate as redox sensors, and their oxidation by hydrogen peroxide directly activates the kinase...
  47. doi Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations
    Ewald Schröder
    King s College London, Department of Cardiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Curr Opin Pharmacol 8:153-9. 2008
    ..However, the intracellular H(2)O(2) may only ever reach 1-15% of the applied exogenous concentration...
  48. ncbi Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia
    Robert Kraft
    Institut fur Pharmakologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Thielallee 69 73, 14195 Berlin, Germany
    Am J Physiol Cell Physiol 286:C129-37. 2004
    ..The increased sensitivity to H2O2 in LPS-stimulated cells suggests a role for TRPM2 in the calcium signaling of activated microglia...
  49. doi Low-molecular-weight oxidants involved in disulfide bond formation
    Lloyd W Ruddock
    Department of Biochemistry, University of Oulu, Finland
    Antioxid Redox Signal 16:1129-38. 2012
    ..Hence knowledge of the mechanisms for their formation is critical for understanding a myriad of cellular processes and associated disease states...
  50. ncbi Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst
    Vincent H Ng
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Microbiol 52:1291-302. 2004
    ..These results indicate that the major role of KatG in MTB pathogenesis is to catabolize the peroxides generated by the phagocyte NADPH oxidase; in the absence of this host antimicrobial mechanism, KatG is apparently dispensable...
  51. ncbi Protective role of magnesium in cardiovascular diseases: a review
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
    Mol Cell Biochem 238:163-79. 2002
    ..Further research are needed for the incorporation of these findings toward the development of novel myocardial protective role of Mg2+ to reduce morbidity and mortality of patients suffering from a variety of cardiac diseases...
  52. ncbi Advanced glycation end product homeostasis: exogenous oxidants and innate defenses
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1126:46-52. 2008
    ..Data in humans confirm the hypothesis that advanced glycation end products (AGEs) and other oxidants derived from the diet may be major contributors to increased OS in normal adults as well as those with diabetes ..
  53. ncbi Plasmalogens: targets for oxidants and major lipophilic antioxidants
    B Engelmann
    Vaskuläre Biologie und Hämostase, Institut fur Klinische Chemie, Ludwig Maximilians Universitat, 81377 Munchen, Germany
    Biochem Soc Trans 32:147-50. 2004
    ..The plasmalogen-specific enol ether double bond is targeted by a vast variety of oxidants, including peroxyl radicals, metal ions, singlet oxygen and halogenating species...
  54. pmc Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
    ..Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role...
  55. pmc Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Free Radic Biol Med 49:1273-82. 2010
    ..RW injury of renal tubular cells and suggest that therapeutic inhibition of these pathways may protect the donor kidney...
  56. doi Hydrogen peroxide induces neurite degeneration: Prevention by tocotrienols
    Koji Fukui
    Physiological Chemistry Laboratory, Department of Bioscience and Engineering, College of Systems Engineering and Sciences, Shibaura Institute of Technology, Fukasaku 307, Minuma ku, Saitama, 337 8570, Japan
    Free Radic Res 45:681-91. 2011
    ..Treatment with tocotrienols may protect neurite function through its neuroprotective function...
  57. ncbi Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications
    P Calcerrada
    Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800, Montevideo, Uruguay
    Curr Pharm Des 17:3905-32. 2011
    ..Although nitric oxide is a mildly reactive intermediary, it can act as a precursor of strong oxidants under pathological conditions associated with oxidative stress including cardiovascular, inflammatory and ..
  58. pmc Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
    Jean Cadet
    Direction des Sciences de Matière, Institut Nanosciences et Cryogenie, CEA Grenoble, Grenoble Cedex 9, France
    Free Radic Res 46:367-81. 2012
    ....
  59. pmc Subcellular targeting of oxidants during endothelial cell migration
    Ru Feng Wu
    University of Texas Southwestern, Dallas, TX 75390, USA
    J Cell Biol 171:893-904. 2005
    Endogenous oxidants participate in endothelial cell migration, suggesting that the enzymatic source of oxidants, like other proteins controlling cell migration, requires precise subcellular localization for spatial confinement of ..
  60. ncbi Molecular dynamics simulations of atmospheric oxidants at the air-water interface: solvation and accommodation of OH and O3
    John Vieceli
    Environmental Molecular Science Institute and Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    J Phys Chem B 109:15876-92. 2005
    ..The implications of these results with respect to atmospheric chemistry are discussed...
  61. pmc Toll-like receptor 2 is essential for the sensing of oxidants during inflammation
    Mark J Paul-Clark
    Cardiothoracic Pharmacology, Cardiothoracic and Stem Cell Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 179:299-306. 2009
    The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood.
  62. pmc Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13
    Junmei Chen
    Research Division, Puget Sound Blood Center, Seattle, WA, USA
    Blood 115:706-12. 2010
    ..Taken together, these findings indicate that reactive oxygen species released by activated neutrophils have a prothrombotic effect, mediated in part by inhibition of VWF cleavage by ADAMTS13...
  63. pmc Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
    ..exacerbation, decrements in pulmonary function, and mortality underscores the important detrimental effects of oxidants on public health...
  64. pmc Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction
    Amy M Furda
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    DNA Repair (Amst) 11:684-92. 2012
    ..These results suggest that persistent mtDNA damage is not sufficient to cause mitochondrial dysfunction...
  65. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    Exposure of cells to sublethal oxidative stress results in the modulation of various signaling pathways. Oxidants can activate and inactivate transcription factors, membrane channels, and metabolic enzymes, and regulate calcium-dependent ..
  66. doi Serum oxidant and antioxidant status during early and late recovery periods following an all-out 21-km run in trained adolescent runners
    Ye Tian
    China Institute of Sport Science, 11 Tiyuguan Road, Chongwen District, Beijing, China
    Eur J Appl Physiol 110:971-6. 2010
    ....
  67. ncbi The carbonate radical and related oxidants derived from bicarbonate buffer
    Danilo B Medinas
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    IUBMB Life 59:255-62. 2007
    ..reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate-carbon dioxide pair...
  68. pmc Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization
    John J Reiners
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 50:281-94. 2011
    ..cholesterol/sterol content modulates susceptibility to ROS-induced LMP and possibly does so by being an alternative target for oxidants and lowering the probability of damage to other lysosomal membrane lipids and/or proteins.
  69. doi Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein
    Mei Hua Jin
    Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Environ Toxicol 25:1-8. 2010
    ..In addition, oxidative stress is a major mediator of TCDD-induced adverse effects, and p53 may play an important role in this mechanism...
  70. ncbi Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases
    D I Pattison
    The Heart Research Institute, 114 Pyrmont Bridge Rd, Camperdown, Sydney, NSW 2050, Australia
    Curr Med Chem 13:3271-90. 2006
    ..A key function of MPO is the production of hypohalous acids (HOX, X = Cl, Br) which are strong oxidants with potent antibacterial properties...
  71. doi Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals
    H Babich
    Department of Biology, Stern College for Women, Yeshiva University, 245 Lexington Avenue, New York, NY 10016, USA
    In Vitro Cell Dev Biol Anim 45:226-33. 2009
    ..This study suggested that the pyruvate status of Dulbecco's modified Eagle's medium be specified in the experimental design, especially in studies involving oxidative stress...
  72. pmc Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis
    E Gottlieb
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 20:5680-9. 2000
    ..of Bcl-x(L) on the cellular redox state after treatment with tumor necrosis factor alpha (TNF-alpha) or exogenous oxidants. We show that in cells that undergo TNF-alpha-induced apoptosis, TNF-alpha induces a partial decrease in ..
  73. ncbi Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidants
    Anna Alisi
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, I 00165 Rome, Italy
    Int J Mol Med 24:319-26. 2009
    ..In conclusion, our findings suggest that glutathionylation inhibits NF-kappaB activity causing reduced hepatocyte survival, which is common in several liver diseases...
  74. doi Quantification of protein modification by oxidants
    Clare L Hawkins
    The Heart Research Institute, Camperdown, NSW, Australia
    Free Radic Biol Med 46:965-88. 2009
    ..Exposure of proteins to these oxidants results in loss of the parent amino acid residue, formation of unstable intermediates, and the generation of ..
  75. ncbi Reactions of biological oxidants with selenourea: formation of redox active nanoselenium
    B Mishra
    Radiation Chemistry and Chemical Dynamics Division and Novel Materials and Structural Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
    J Phys Chem B 109:12718-23. 2005
    ..The studies demonstrate that selenourea undergoes oxidation with both one-electron and two-electron oxidants to produce elemental selenium, which, on stabilization to nanometer size, exhibits size-dependent redox activity.
  76. ncbi Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide
    Jane K Finzi
    Departamento de Bioquimica, IB, UNICAMP, Campinas, SP, Brazil
    Mol Biochem Parasitol 133:37-43. 2004
    ..An increase in glucose-6-phosphate dehydrogenase activity was observed in pTEX-TcCPX epimastigotes that could provide cells with extra reducing power and a higher growth index...
  77. ncbi Alcohol, stroke and coronary heart disease. Are there anti-oxidants and pro-oxidants in alcoholic beverages that might influence the development of atherosclerotic cardiovascular disease?
    I B Puddey
    Department of Medicine and Western Australian Heart Research Institute, University of Western Australia, Perth, Australia
    Neuroepidemiology 18:292-302. 1999
    ..laboratory studies, the conclusion at present is that while we may continue to speculate that there are anti-oxidants and pro-oxidants in alcoholic beverages that influence the development of atherosclerotic cardiovascular disease, ..
  78. ncbi Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies
    R Beck
    Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Belgium
    Curr Med Chem 18:2816-25. 2011
    ..Overall, these results highlight the potential interest of using oxidative stress to target Hsp90...
  79. doi Effect of simulated microgravity on salivary and serum oxidants, antioxidants, and periodontal status
    Balwant Rai
    Oral Imaging Center, School of Dentistry, Oral Pathology, and Maxillofacial Surgery, Catholic University Leuven, Leuven, Belgium
    J Periodontol 82:1478-82. 2011
    ..The objective of the study is to determine the influence of simulated microgravity on the periodontal status and salivary and serum oxidant/antioxidant status of the body in simulated microgravity (-6° head-down-tilt [HDT) bed rest)...
  80. doi Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling
    Michel Rigoulet
    Universite Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell IBGC du CNRS, Bordeaux, France
    Antioxid Redox Signal 14:459-68. 2011
    ..The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed...
  81. ncbi Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP
    Shyra J Gardai
    Program in Cell Biology, The Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 279:44695-703. 2004
    ..apoptosis in neutrophils is enhanced by "stress" stimuli such as tumor necrosis factor-alpha, Fas ligand, and oxidants, and this effect is inhibited by anti-apoptotic stimuli including granulocyte-macrophage colony-stimulating ..
  82. ncbi Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    Ernst Malle
    Medical University Graz, Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Harrachgasse 21, A 8010 Graz, Austria
    Biochim Biophys Acta 1761:392-415. 2006
    ..The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, ..
  83. ncbi Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing
    Christine C Winterbourn
    Department of Pathology, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 281:39860-9. 2006
    ..However, the role of oxidants in killing and the species responsible are poorly understood and the subject of current debate...
  84. ncbi The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study
    Ojia Skaff
    The Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, Sydney, NSW 2050, Australia
    Biochemistry 47:8237-45. 2008
    ....
  85. pmc Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury
    Claudie M Hecquet
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA
    Thromb Haemost 101:619-25. 2009
    ..This review summarizes recent findings on the mechanism by which oxidants induce TRPM2 activation, the role of these channels in the signalling vascular endothelial dysfunctions, and the ..
  86. ncbi Characterization of the SKN7 ortholog of Aspergillus fumigatus
    Claude Lamarre
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Cedex 15, France
    Fungal Genet Biol 44:682-90. 2007
    ..This result indicated that an increased sensitivity of A. fumigatus to peroxides in vitro is not correlated with a modification of fungal virulence...
  87. ncbi Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling
    Quentin Felty
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Oncogene 24:4883-93. 2005
    ..Thus, our results suggest (1) a new paradigm that estrogen-induced mitochondrial oxidants control the early stage of cell cycle progression and (2) provide the basis for the discovery of novel ..
  88. pmc Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    D K Kaul
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 106:411-20. 2000
    ..These findings suggest that leukocyte-endothelium interaction contribute to vasoocclusive events in the sickle mice and perhaps in human sickle disease...
  89. ncbi Role of oxidants in lung injury during sepsis
    Ren Feng Guo
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Antioxid Redox Signal 9:1991-2002. 2007
    ..However, the results are inconclusive. In this article, we focus on the current understanding of the pathogenesis of sepsis-induced ALI and novel antioxidant strategies for therapeutic purposes...
  90. ncbi The catalase and superoxide dismutase genes are transcriptionally up-regulated upon oxidative stress in the strictly anaerobic archaeon Methanosarcina barkeri
    Andrei L Brioukhanov
    Department of Microbiology, Biological Faculty, Lomonosov Moscow State University, Vorob evy Hills 1 12, 119992 Moscow, Russia
    Microbiology 152:1671-7. 2006
    ..PQ and to a lesser degree H2O2 induced the expression of superoxide dismutase. The results indicate the regulation of the adaptive response of M. barkeri to different oxidative stresses...
  91. ncbi Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity
    H Maharaj
    Division of Pharmacology, Faculty of Pharmacy, Rhodes University, Grahamstown 6139, South Africa
    Metab Brain Dis 21:189-99. 2006
    ..In addition these agents inhibit the enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO), responsible for the synthesis of endogenous QA...
  92. ncbi Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    S L Hempel
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, University of Iowa, Iowa City 52242, USA
    Free Radic Biol Med 27:146-59. 1999
    ..tests the hypothesis that dihydrofluorescein diacetate is a better fluorescent probe for detecting intracellular oxidants because it is more reactive toward specific oxidizing species...
  93. doi Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase
    Beatrix A Olofsson
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Mol Cancer Res 5:1319-30. 2007
    ..Together, these data show that Sp1 is a novel ATM substrate that plays a role in the cellular response to DNA damage...
  94. ncbi Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1117-29. 2003
    ..In addition to their capacity to damage macromolecules, oxidants play important roles in the initiation of numerous signal transduction pathways that are linked to apoptosis, ..
  95. ncbi Oxidant-dependent switching between reversible and sacrificial oxidation pathways for Bacillus subtilis OhrR
    Sumarin Soonsanga
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    Mol Microbiol 68:978-86. 2008
    ..Thus, depending on the oxidant, OhrR can be either reversibly oxidized or can instead function as a sacrificial regulator...
  96. pmc Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan
    Martin D Rees
    The Heart Research Institute, 114 Pyrmont Bridge Rd Camperdown, Sydney NSW, Australia
    Matrix Biol 29:63-73. 2010
    The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes...
  97. doi Cells deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to oxidants with increased G2/M arrest and multinucleation
    Yali Xie
    Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, MB R3E 0W9, Canada
    Carcinogenesis 29:722-8. 2008
    ..Myh and Ogg1 double knockout cells were more sensitive than wild type to oxidants (hydrogen peroxide and t-butyl hydroperoxide), but not to cis-platinum or gamma-irradiations...
  98. pmc Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:1940-5. 2006
    ..live cells undergoes continuous oxidative damage caused by metabolically generated endogenous as well as external oxidants and oxidant-inducers...
  99. ncbi Advanced glycation end products and cardiovascular disease
    Melpomeni Peppa
    Endocrine Unit, 2nd Department of Internal Medicine Propaedeutic, Research Institute and Diabetes Center, Attikon University Hospital, Athens, Greece
    Curr Diabetes Rev 4:92-100. 2008
    ..Recent in vitro and in vivo studies revealed significant correlations between diet-derived AGEs and several risk factors and/or markers of CVD, suggesting the dietary AGEs restriction as a promising therapeutic intervention...
  100. pmc SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    Samuel Caito
    Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
    FASEB J 24:3145-59. 2010
    ..b>Oxidants, aldehydes, and CS induced carbonyl modifications on SIRT1 on cysteine residues concomitant with decreased SIRT1 ..
  101. ncbi Oxidants in the gas phase of cigarette smoke pass through the lung alveolar wall and raise systemic oxidative stress
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Kyuban cho, Nishinomiya, Japan
    J Pharmacol Sci 103:275-82. 2007
    ..Aqueous cigarette smoke extract (CSE) contains stable oxidants, peroxynitrite-like reactants, which have the ability to oxidize and nitrate low-density lipoprotein (LDL)...

Research Grants78

  1. 2007 NIH Director's Pioneer Award Program (DP1)
    Rustem Ismagilov; Fiscal Year: 2009
    ..These two technologies will be used together to understand protein aggregation and aging, and may lead to new hypothesis and molecules for controlling these processes. ..
  2. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..survival in human PMNs in vitro, adherence to human esophageal tissue, quorum sensing and adaptation to oxidants. These features make two-component proteins very attractive targets for antifungal drug discovery since they have ..
  3. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    WILLIAM NAUSEEF; Fiscal Year: 2009
    ..composition of their cell surface (including content of D-alanine and cardiolipin) and to induce cytoplasmic anti-oxidants (e.g...
  4. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Gary Bokoch; Fiscal Year: 2000
    ..Abstract) The NADPH oxidase of human phagocytes is responsible for the formation of superoxide anion and other oxidants used by these cells for bacterial killing, and is also an important component of the inflammatory response...
  5. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Gary Bokoch; Fiscal Year: 1999
    ..Abstract) The NADPH oxidase of human phagocytes is responsible for the formation of superoxide anion and other oxidants used by these cells for bacterial killing, and is also an important component of the inflammatory response...
  6. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2011
    ..Nrf2, a zinc-finger protein that turns on a genetic program that stimulates the production of multiple anti-oxidants including glutathione...
  7. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    ..In certain airway disorders, including those due to oxidants such as ozone, endogenous airway NEP activity is decreased...
  8. Heme Oxygenase-1 Inhibition of Hepatitis C Replication
    Warren Schmidt; Fiscal Year: 2009
    ..Hepatic injury is likely initiated by oxidants such as superoxide and peroxide that arise during viral infection and damage hepatocytes and surrounding cells...
  9. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Karl Roth; Fiscal Year: 2001
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  10. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2002
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  11. PEDIATRIC NEPHROLOGY TRAINING GRANT
    James Chan; Fiscal Year: 2000
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  12. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  13. PEDIATRIC NEPHROLOGY TRAINING GRANT
    James Chan; Fiscal Year: 1999
    ..Povlishock); endothelial cell, glycolipid and immune injury mechanisms (Dr. Yu); oxidants and antioxidants in tissue damage and repair (Drs. W. Chan, N. Kuemmerle)...
  14. COMPLEX III AUGMENTS OXIDANTS DAMAGE IN ISCHEMIC AGED HEART
    EDWARD LESNEFSKY JR; Fiscal Year: 2004
    ..Enhanced ROS release from mitochondria, in turn, amplifies cardiac damage and dysfunction during reperfusion that can be decreased by reversibly limiting electron flow into complex III during ischemia. ..
  15. Surgical Intramyocardial Angiogenesis in a Swine Model of Endothelial Dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..Angiogenesis is regulated by redox-sensing transcription factors such as nuclear factor kb and oxidants such as hydrogen peroxide and free radicals such as NO...
  16. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2003
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  17. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2002
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  18. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2002
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  19. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..In volunteers consuming diets low in anti-oxidants for 3 weeks, raising plasma NEFAs with an infusion of Intralipid and heparin increased blood pressure (BP) about ..
  20. OXYGEN RADICALS, OXIDANTS AND MEMBRANE DYSFUNCTION
    RAKESH KUKREJA; Fiscal Year: 1990
    ..changes that occur in these organelles as a result of attack by oxygen free radicals and neutrophil derived oxidants. The specific aim of this project is to answer the following three hypotheses...
  21. MODULATION OF CIGARETTE SMOKE INDUCED OXIDATIVE DAMAGE
    Emerich Fiala; Fiscal Year: 2002
    ..The work proposed here is a logical extension of these findings. We postulate that cigarette smoke-derived oxidants, probably H2O2 and/or peroxynitrite, activate the transcription factors NF-kappaB and AP-1, and that this is an ..
  22. MODULATION OF CIGARETTE SMOKE INDUCED OXIDATIVE DAMAGE
    Emerich Fiala; Fiscal Year: 2001
    ..The work proposed here is a logical extension of these findings. We postulate that cigarette smoke-derived oxidants, probably H2O2 and/or peroxynitrite, activate the transcription factors NF-kappaB and AP-1, and that this is an ..
  23. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2012
    ..elegans. Several long-lived mouse mutants are also resistant to multiple forms of stress, including oxidants, UV, and heavy metals. This relationship holds equally true for the exceptionally long-lived naked mole rat...
  24. DETOXIFICATION OF XENOBIOTICS IN OCULAR TISSUES
    YOGESH AWASTHI; Fiscal Year: 1990
    ..GSH) plays an important role in protecting the ocular tissues from the oxidative stress due to endogenous oxidants, as well as from the environmental pollutants, and xenobiotics...
  25. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2003
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  26. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2002
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  27. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2004
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  28. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2005
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  29. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2[unreadable]>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-..
  30. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2002
    ..and HOSCN. The relative toxicity of these oxidants for human cells is HOBr> NO2>> HOSCN; yet EPO preferentially oxidizes SCN > NO2 - > Br-...
  31. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
    The decision between death or survival of lung epithelial cells exposed to oxidants is regulated by multiple signaling pathways...
  32. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants will result in a decrease in anti-oxidant defense...
  33. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..The adverse molecular actions of oxidants have largely been attributed to their role in causing damage...
  34. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants will result in a decrease in anti-oxidant defense...
  35. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2003
    ..Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants will result in a decrease in anti-oxidant defense...
  36. C MYC--TRANSCRIPTION AND APOPTOSIS
    CHI DANG; Fiscal Year: 2009
    ..We previously hypothesized that anti- oxidants, such as N-acetylcysteine or vitamin C, decrease tumorigenesis by interfering with genomic instability by ..
  37. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2010
    ..We previously hypothesized that anti- oxidants, such as N-acetylcysteine or vitamin C, decrease tumorigenesis by interfering with genomic instability by ..
  38. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2009
    ..of EO peroxidase (EPO) and a vigorous respiratory burst that generates H2O2 to fuel the generation of other oxidants. However, little is known about the contribution of EPO-mediated oxidative damage to the pathology of ..
  39. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2010
    ..of EO peroxidase (EPO) and a vigorous respiratory burst that generates H2O2 to fuel the generation of other oxidants. However, little is known about the contribution of EPO-mediated oxidative damage to the pathology of ..
  40. Mitochondrial Dysfunction in Neurodegeneration of Aging
    Gary E Gibson; Fiscal Year: 2010
    ..rate limiting step for NADH formations, produces ROS, is obligatory for heme production, and is very sensitive to oxidants. TGase is a cross linking enzymes that can modulate transcription, inactivate metabolic enzymes, and cause ..
  41. Oxidant Stress: Is it a biomarker of disease progression and response to therapy
    Jesse Roman; Fiscal Year: 2010
    ..Several studies have demonstrated decreased levels of anti- oxidants in patients with IPF, and anti-oxidant strategies seem effective in animal models of lung fibrosis...
  42. Oxidant Stress: Is it a biomarker of disease progression and response to therapy
    Jesse Roman; Fiscal Year: 2009
    ..Several studies have demonstrated decreased levels of anti- oxidants in patients with IPF, and anti-oxidant strategies seem effective in animal models of lung fibrosis...
  43. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2004
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  44. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2005
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  45. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2001
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  46. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2002
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  47. Nutritional Etiology of Pre-Diabetic Autoimmunity
    Jill Norris; Fiscal Year: 2003
    ..follow-up of these cohorts has already provided new important information concerning the role of vitamins, anti-oxidants and oxidative stress in the etiology of type 1 diabetes, as well as data suggesting a role for fatty acids...
  48. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2003
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  49. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2005
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  50. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  51. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2006
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  52. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2004
    ..mitochondrial release of cytochrome c (cyt c) and caspase activation is a mechanism common to toxicity induced by oxidants and alkylating agents...
  53. A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitus
    Todd Perlstein; Fiscal Year: 2011
    ..Oxidative stress, defined as an excess of oxidants relative to antioxidants, in large part drives the vascular complications of T1DM...
  54. EFFECTS OF ETHANOL AND ACETALDEHYDE ON LIVER FUNCTION
    Arthur Cederbaum; Fiscal Year: 1990
    ..of ferritin to catalyze NADH- and NADPH-dependent generation of active oxygen radicals and interact with pro-oxidants will be determined...
  55. EFFECTS OF ETHANOL AND ACETALDEHYDE ON LIVER FUNCTION
    Arthur Cederbaum; Fiscal Year: 1992
    ..of ferritin to catalyze NADH- and NADPH-dependent generation of active oxygen radicals and interact with pro-oxidants will be determined...
  56. EFFECTS OF ETHANOL AND ACETALDEHYDE ON LIVER FUNCTION
    Arthur Cederbaum; Fiscal Year: 1993
    ..of ferritin to catalyze NADH- and NADPH-dependent generation of active oxygen radicals and interact with pro-oxidants will be determined...
  57. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2001
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  58. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2000
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  59. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2001
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  60. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2002
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  61. CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESS
    Kandatege Wimalasena; Fiscal Year: 2003
    ..Although, most of the reactive radical species and oxidants are effectively scavenged by enzymatic defense mechanisms and by cellular oxidants, their excessive generation ..
  62. Mechanisms of Embryo Response to Oxidative Stress
    Mark E Hahn; Fiscal Year: 2010
    ..The expression and inducibility of anti-oxidant defenses are critical factors affecting susceptibility to oxidants at these early life stages, but the ontogenic development of these responses in embryos is not well understood...
  63. Mechanisms of Embryo Response to Oxidative Stress
    MARK HAHN; Fiscal Year: 2009
    ..The expression and inducibility of anti-oxidant defenses are critical factors affecting susceptibility to oxidants at these early life stages, but the ontogenic development of these responses in embryos is not well understood...
  64. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  65. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2002
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  66. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2000
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  67. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2001
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  68. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2001
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  69. BIOCHEMICAL MECHANISMS OF REPERFUSION LUNG INJURY
    Thomas Kennedy; Fiscal Year: 1990
    Injury from oxidants generated during reperfusion of ischemic tissue has been reported in a number of organs but is not well studied in the lung...
  70. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2002
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...
  71. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2004
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...
  72. AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETING
    Vladimir Muzykantov; Fiscal Year: 2002
    ..and enables intracellular delivery of the enzymes, for either intracellular generation of detoxification of oxidants. We postulate that this latter property will be critical for effective protection against oxidants generated by ..
  73. AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETING
    Vladimir Muzykantov; Fiscal Year: 2000
    ..and enables intracellular delivery of the enzymes, for either intracellular generation of detoxification of oxidants. We postulate that this latter property will be critical for effective protection against oxidants generated by ..
  74. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2001
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...
  75. AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETING
    Vladimir Muzykantov; Fiscal Year: 1999
    ..and enables intracellular delivery of the enzymes, for either intracellular generation of detoxification of oxidants. We postulate that this latter property will be critical for effective protection against oxidants generated by ..
  76. AUGMENTATION OF ANTIOXIDANT DEFENSES BY IMMUNOTARGETING
    Vladimir Muzykantov; Fiscal Year: 2001
    ..and enables intracellular delivery of the enzymes, for either intracellular generation of detoxification of oxidants. We postulate that this latter property will be critical for effective protection against oxidants generated by ..
  77. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2003
    ..Alterations in endothelial cell production of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases...