cation exchange resins

Summary

Summary: High molecular weight insoluble polymers which contain functional anionic groups that are capable of undergoing exchange reactions with cations.

Top Publications

  1. ncbi Cation exchange chromatography in antibody purification: pH screening for optimised binding and HCP removal
    Andreas Stein
    Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 848:151-8. 2007
  2. ncbi Influence of acidic eluent for retention behaviors of common anions and cations by ion-exclusion/cation-exchange chromatography on a weakly acidic cation-exchange resin in the H+ -form
    Masanobu Mori
    Faculty of Engineering, Gunma University, Kiryu, Gunma 376 8515, Japan
    J Chromatogr A 1118:51-5. 2006
  3. ncbi Monolithic column with double mixed-modes of hydrophilic interaction/cation-exchange and reverse-phase/cation-exchange stationary phase for pressurized capillary electrochromatography
    Jiabin Wang
    Department of Chemistry, Fuzhou University, Fuzhou, Fujian, P R China
    Electrophoresis 29:928-35. 2008
  4. ncbi Solid-phase refolding of cyclodextrin glycosyltransferase adsorbed on cation-exchange resin
    Dae Hyuk Kweon
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Korea
    Biotechnol Prog 20:277-83. 2004
  5. ncbi Preparation and characterization of prototypes for multi-modal separation aimed for capture of positively charged biomolecules at high-salt conditions
    Bo Lennart Johansson
    Research and Development, Amersham Biosciences, SE 751 84, Uppsala, Sweden
    J Chromatogr A 1016:35-49. 2003
  6. ncbi Mass transfer effects in preparative chromatography of eremomycin on polymeric sorbents
    Irina V Polyakova
    Department of Biopolymers, Institute of Molecular Compounds, Russian Academy of Sciences, Bolshoi pr 31, St Petersburg, Russia
    J Chromatogr A 1006:251-60. 2003
  7. ncbi Sample clean-up method for analysis of complex-type N-glycans released from glycopeptides
    Miyako Nakano
    Faculty of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, Higashi Osaka 577 8502, Japan
    J Chromatogr A 1005:13-21. 2003
  8. ncbi High-speed simultaneous ion-exclusion/cation-exchange chromatography of anions and cations on a weakly acidic cation-exchange resin column
    Masanobu Mori
    National Institute of Advanced Industrial Science and Technology at Seto, 110 Nishiibara cho, Seto, Aichi 489 0884, Japan
    J Chromatogr A 997:219-24. 2003
  9. ncbi Vacancy ion-exclusion chromatography of aromatic carboxylic acids on a weakly acidic cation-exchange resin
    Murad I H Helaleh
    National Institute of Advanced Industrial Science and Technology, Graduate School of Engineering, Chubu University, Seto 489 0884, Japan
    J Chromatogr A 997:139-44. 2003
  10. ncbi Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin
    Murad I H Helaleh
    National Institute of Advanced Industrial Science and Technology, 110 Nishiibara cho, Seto, Aichi 489 0884, Japan
    J Chromatogr A 997:133-8. 2003

Research Grants

  1. Synthetic Peptide Consensus Sequence Vaccine Development
    Robert Hodges; Fiscal Year: 2005
  2. Bone Quality and Mechanical Competence In Chronic Kidney Disease
    Thomas Nickolas; Fiscal Year: 2008
  3. HPLC OF PEPTIDES AND PROTEINS
    Robert Hodges; Fiscal Year: 2001
  4. Alpbach Workshop:Coiled-Coils, Collagen/Co-proteins
    Robert Hodges; Fiscal Year: 2005
  5. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2006
  6. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2007
  7. Design of New Antimicrobials
    Robert Hodges; Fiscal Year: 2008
  8. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2009
  9. Design of New Antimicrobials
    Robert Hodges; Fiscal Year: 2009
  10. Design of New Antimicrobials
    Robert S Hodges; Fiscal Year: 2010

Detail Information

Publications163 found, 100 shown here

  1. ncbi Cation exchange chromatography in antibody purification: pH screening for optimised binding and HCP removal
    Andreas Stein
    Merck KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 848:151-8. 2007
    ..With this pH we ran labscale columns to purify monoclonal antibody. The cation exchangers showed high step yields and host cell proteins in the pools from gradient elution were reduced very effectively...
  2. ncbi Influence of acidic eluent for retention behaviors of common anions and cations by ion-exclusion/cation-exchange chromatography on a weakly acidic cation-exchange resin in the H+ -form
    Masanobu Mori
    Faculty of Engineering, Gunma University, Kiryu, Gunma 376 8515, Japan
    J Chromatogr A 1118:51-5. 2006
    ..1-2.9% for anions and 1.8-4.5% for cations. This method was successfully applied to hot spring water containing strong acid anions, weak acid anions and cations, with satisfactory results...
  3. ncbi Monolithic column with double mixed-modes of hydrophilic interaction/cation-exchange and reverse-phase/cation-exchange stationary phase for pressurized capillary electrochromatography
    Jiabin Wang
    Department of Chemistry, Fuzhou University, Fuzhou, Fujian, P R China
    Electrophoresis 29:928-35. 2008
    ..Effects of salt concentration and ACN content on the separation have also been investigated. High column efficiencies of up to 352 000 plates/meter were obtained by the separation of narcotic pharmaceuticals...
  4. ncbi Solid-phase refolding of cyclodextrin glycosyltransferase adsorbed on cation-exchange resin
    Dae Hyuk Kweon
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Korea
    Biotechnol Prog 20:277-83. 2004
    ..Taken together with the previous report in which a series of polycations were explored for efficient purification, expression of a target protein fused with a strong polycation provides a straightforward protein preparation scheme...
  5. ncbi Preparation and characterization of prototypes for multi-modal separation aimed for capture of positively charged biomolecules at high-salt conditions
    Bo Lennart Johansson
    Research and Development, Amersham Biosciences, SE 751 84, Uppsala, Sweden
    J Chromatogr A 1016:35-49. 2003
    ..Varying the ligand ratio (SP/Phenyl) could be used for optimizing the function of mixed-ligand ion-exchange media...
  6. ncbi Mass transfer effects in preparative chromatography of eremomycin on polymeric sorbents
    Irina V Polyakova
    Department of Biopolymers, Institute of Molecular Compounds, Russian Academy of Sciences, Bolshoi pr 31, St Petersburg, Russia
    J Chromatogr A 1006:251-60. 2003
    ..The optimal conditions for sorption and complete desorption of eremomycin were found...
  7. ncbi Sample clean-up method for analysis of complex-type N-glycans released from glycopeptides
    Miyako Nakano
    Faculty of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, Higashi Osaka 577 8502, Japan
    J Chromatogr A 1005:13-21. 2003
    ..In the model study presented here, we were able to obtain N-glycans for HPAEC analyses without any interfering materials by a combination of TNBS reaction and graphitized carbon treatment...
  8. ncbi High-speed simultaneous ion-exclusion/cation-exchange chromatography of anions and cations on a weakly acidic cation-exchange resin column
    Masanobu Mori
    National Institute of Advanced Industrial Science and Technology at Seto, 110 Nishiibara cho, Seto, Aichi 489 0884, Japan
    J Chromatogr A 997:219-24. 2003
    ..36 to 0.68 microM for anions and 0.63-0.99 microM for cations. This method has been applied to the simultaneous determination of anions and cations in several environmental waters with satisfactory results...
  9. ncbi Vacancy ion-exclusion chromatography of aromatic carboxylic acids on a weakly acidic cation-exchange resin
    Murad I H Helaleh
    National Institute of Advanced Industrial Science and Technology, Graduate School of Engineering, Chubu University, Seto 489 0884, Japan
    J Chromatogr A 997:139-44. 2003
    ..66, 0.67, 0.42 and 0.86 microM and detector responses were linear in the range 1-100, 1-80, 2.5-100 and 10-40 microM, for SA, NTCA, PA and BA, respectively. Precision for retention times was 0.36% and for peak areas was 1.5%...
  10. ncbi Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin
    Murad I H Helaleh
    National Institute of Advanced Industrial Science and Technology, 110 Nishiibara cho, Seto, Aichi 489 0884, Japan
    J Chromatogr A 997:133-8. 2003
    ..The detection limits of these acids in the present study with conductivity detection were 3.4 microM for monochloroacetic acid, 0.86 microM for dichloroacetic acid and 0.15 microM for trichloroacetic acid...
  11. ncbi Ion-exclusion chromatography with conductimetric detection of aliphatic carboxylic acids on a weakly acidic cation-exchange resin by elution with benzoic acid-beta-cyclodextrin
    Kazuhiko Tanaka
    National Institute of Advanced Industrial Science and Technology, 110 Nishiibara cho, Seto, Aichi 489 0884, Japan
    J Chromatogr A 997:127-32. 2003
    ..The ion-exclusion chromatographic separation of carboxylic acids with high resolution and sensitivity was accomplished successfully by elution with a 1 mM benzoic acid-10 mM cyclodextrin solution without chemical suppression...
  12. doi Simultaneous determination of cations, zwitterions and neutral compounds using mixed-mode reversed-phase and cation-exchange high-performance liquid chromatography
    Jingyi Li
    Analytical Research and Development, Celgene Corporation, Summit, NJ 07091, USA
    J Chromatogr A 1185:185-93. 2008
    ..Moreover, the method performance characteristics of selectivity, sensitivity and accuracy have been demonstrated to be suitable to determine the related impurities in the capsules of Drug A...
  13. doi Theory and applications of a novel ion exchange chromatographic technology using controlled pH gradients for separating proteins on anionic and cationic stationary phases
    Latchezar I Tsonev
    CryoBioPhysica, Inc, Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    J Chromatogr A 1200:166-82. 2008
    ....
  14. doi Preparative weak cation-exchange chromatography of monoclonal antibody variants I. Single-component adsorption
    Lena Melter
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    J Chromatogr A 1200:156-65. 2008
    ..A correlation describing the effect of the separation conditions on the diffusion rate is therefore needed in order to have a fully predictive mathematical model...
  15. ncbi Sulfonated and sulfoacylated poly(styrene-divinylbenzene) copolymers as packing materials for cation chromatography
    Andrey V Pirogov
    Chemistry Department, Moscow State University, GPS 2, Lenin Hills, 119992, Moscow, Russia
    Anal Bioanal Chem 376:745-52. 2003
    ..It was found that the separation of alkaline ions and 1,1-dimethylhydrazine (UDMH) were much better that those for the commercial material...
  16. ncbi Novel cation-exchange column for the separation of hydrophobic and/or polyvalent amines
    Maria Rey
    Dionex Corporation, 1228 Titan Way, Sunnyvale, CA 94085, USA
    J Chromatogr A 997:199-206. 2003
    ..Examples are given. Methods that require eluent gradients and/or step changes of eluent concentration are especially well suited to this column because the background conductivity remains almost unchanged under gradient conditions...
  17. ncbi High-performance cation-exchange chromatofocusing of proteins
    Xuezhen Kang
    Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Chromatogr A 991:117-28. 2003
    ....
  18. ncbi Parallel screening of selective and high-affinity displacers for proteins in ion-exchange systems
    Kaushal Rege
    Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
    J Chromatogr A 1033:19-28. 2004
    ..The results presented in this paper demonstrate that this parallel batch screening-QSER approach can be employed for the identification of selective and high-affinity displacers for protein mixtures...
  19. ncbi Relative retention of the fibroblast growth factors FGF-1 and FGF-2 on strong cation-exchange sorbents
    Peter DePhillips
    Merck Research Laboratories, Sumneytown Road, West Point, PA 19486, USA
    J Chromatogr A 1036:51-60. 2004
    ..These observations are interpreted in terms of the structural features of the proteins and the physicochemical properties of the adsorbents...
  20. doi Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups
    Timothy M Pabst
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904 4741, USA
    J Chromatogr A 1181:83-94. 2008
    ....
  21. ncbi [Adsorption condition optimization for anti-HBsAg Fab fragment separation and purification from E. coli using Streamline SP]
    Yu Xian Huang
    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:409-13. 2006
    ..To optimize the adsorption condition of cation-exchange chromatographic media Streamline SP for separation and purification of anti-HBsAg Fab fragment from E. coli...
  22. ncbi Enrichment and identification of cysteine-containing peptides from tryptic digests of performic oxidized proteins by strong cation exchange LC and MALDI-TOF/TOF MS
    Jingquan Dai
    Beijing Institute of Radiation Medicine, China
    Anal Chem 77:7594-604. 2005
    ..The strength of the strategy was demonstrated by applying it to bovine serum albumin. Potential use of the strategy in proteomics was also discussed...
  23. ncbi Characterisation of the novel restriction endonuclease SuiI from Sulfolobus islandicus
    Stefan Söllner
    Institute of Biochemistry, University of Bayreuth, Universitatstrasse 30, 95447 Bayreuth, Germany
    Extremophiles 10:629-34. 2006
    ..The cleavage occurs after the first guanosine base and is inhibited by 5-methyl-cytosine methylation. The restriction activity is salt-sensitive and has an optimal activity around 70 degrees C...
  24. ncbi Role of zwitterionic structures in the solid-phase extraction based method development for clean up of tetracycline and oxytetracycline from honey
    Shahana Huq
    Phenomenex, Inc, 411 Madrid Ave, Torrance, CA 90501, USA
    J Chromatogr A 1135:12-8. 2006
    ....
  25. ncbi Ion exchange chromatography of antibody fragments
    Anders Ljunglöf
    GE Healthcare, Bio Sciences AB, SE 751 84 Uppsala, Sweden
    Biotechnol Bioeng 96:515-24. 2007
    ..Such results are in agreement with recent studies related to ion exchange of whole antibody molecules under similar conditions...
  26. ncbi Simultaneous determination of creatinine, creatine, and UV-absorbing amino acids using dual-mode gradient low-capacity cation-exchange chromatography
    Yukio Yokoyama
    Department of Analytical Chemistry, Faculty of Engineering, Yokohama National University, Tokiwadai, Hodogaya, Yokohama 240 8501, Japan
    J Chromatogr A 1085:110-6. 2005
    ..The developed method is very practical and can provide useful information and results for the clinical or biomedical researches with low analytical run costs...
  27. ncbi Cation exchangers for selective sorption of large proteins
    O V Ochkur
    Institute of Macromolecular Compounds, Russian Academy of Science, Bolshoi pr 31, St Petersburg, Russian Federation
    J Chromatogr B Analyt Technol Biomed Life Sci 849:231-5. 2007
    ..The dependence of sorption selectivity on protein size and on concentration of ionogenic groups was demonstrated...
  28. ncbi Effects of ionic strength on lysozyme uptake rates in cation exchangers. I: Uptake in SP Sepharose FF
    S R Dziennik
    Department of Chemical Engineering, Center for Molecular and Engineering Thermodynamics, University of Delaware, Newark, Delaware 19716, USA
    Biotechnol Bioeng 91:139-53. 2005
    ..In addition, the results provide heuristics for the optimization of chromatographic conditions...
  29. ncbi Application of a chromatography model with linear gradient elution experimental data to the rapid scale-up in ion-exchange process chromatography of proteins
    Takashi Ishihara
    CMC R and D Laboratories, Pharmaceutical Division, Kirin Brewery Co Ltd, Takasaki, Gunma 370 0013, Japan
    J Chromatogr A 1162:34-40. 2007
    ..Resolution, recovery and purity were examined in order to verify the proposed method...
  30. ncbi Rational method for designing efficient separations by chromatography on polystyrene-divinylbenzene resins eluted with aqueous ethanol
    Shuichi Yamamoto
    Laboratory of Bioprocess Engineering, School of Engineering and Graduate School of Medicine, Yamaguchi University, Tokiwadai, Ube 755 8611, Japan
    J Chromatogr A 1162:50-5. 2007
    ..Stepwise elution experiments were also designed and performed successfully on the basis of the K-I curve...
  31. ncbi [Studies of chromatographic behaviors of proteins on synthesized cation-exchanger]
    Rong Li
    School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, China
    Se Pu 22:134-7. 2004
    ..The interaction between chelating weak cation-exchanger and metal ions was examined. The retention mechanism of protein in metal chelating chromatography was explored...
  32. ncbi Automated injection of uncleaned samples using a ten-port switching valve and a strong cation-exchange trap column for proteome analysis
    Fangjun Wang
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    J Chromatogr A 1171:56-62. 2007
    ....
  33. ncbi Effect of spacer arm length on protein retention on a strong cation exchange adsorbent
    Peter DePhillips
    Merck Research Laboratories, Sumneytown Road, West Point, PA 19486, USA
    Anal Chem 76:5816-22. 2004
    ..The results indicate that spacer arm length may be a useful variable in manipulating stationary-phase retention properties...
  34. ncbi Selection of pH-related parameters in ion-exchange chromatography using pH-gradient operations
    Tangir Ahamed
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    J Chromatogr A 1194:22-9. 2008
    ..5 or anion-exchange chromatography (AEX) at pH 7.2 without lowering the salt concentration in the CCS. The performance of both CEX and AEX was predicted to be equal for this particular MAb capture...
  35. ncbi Gravity-flow open tubular cation chromatography
    Petr Kuban
    Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry, Zemedelska 1, Brno, Czech Republic
    J Sep Sci 31:2745-53. 2008
    ..75 mM pyridinedicarboxylic acid as an eluent. Contactless conductometric detection (C(4)D) allows LODs down to 150 nmol/L, corresponding to 30 fmol injections. Analysis of real water samples is demonstrated...
  36. ncbi Co-eluent effect in partition chromatography. Rhamnose-xylose separation with strong and weak cation-exchangers in aqueous ethanol
    Jari Tiihonen
    Lappeenranta University of Technology, Laboratory of Industrial Chemistry, P O Box 20, FIN 53851 Lappeenranta, Finland
    J Chromatogr A 982:69-84. 2002
    ..The experimental data were successfully explained with a rate-based column model, which accounted for the volume changes of the stationary phase. A thermodynamic sorption model was utilized in column calculations...
  37. ncbi Dynamic coating ion-exchange chromatography of cations on an octadecyl-bonded silica stationary phase
    Liang Guo
    Department of Chemistry, Tsinghua University, Beijing, China
    J Chromatogr A 946:169-75. 2002
    ....
  38. ncbi Determinants of protein retention characteristics on cation-exchange adsorbents
    P DePhillips
    Merck Research Laboratories, Sumneytown Rd, West Point, PA 19486, USA
    J Chromatogr A 933:57-72. 2001
    ..Protein retention was increased on adsorbents with pore size distributions that include significant amounts of pore space with dimensions similar to those of the protein solute...
  39. ncbi Protein adsorption on novel acrylamido-based polymeric ion-exchangers. I. Morphology and equilibrium adsorption
    A K Hunter
    Department of Chemical Engineering, University of Virginia, Charlottesville 22903-2442, USA
    J Chromatogr A 897:65-80. 2000
    ..For these ion-exchangers, high protein adsorption capacities are attained when a low-density polymer gel with a high concentration of functional groups is present...
  40. ncbi Synthesis of monodisperse poly(chloromethylstyrene-co-divinylbenzene) beads and their application in separation of biopolymers
    Bolin Gong
    Key Laboratory of Energy and Chemical Engineering, Ningxia University, Yinchuan 750021, P R China
    J Sep Sci 28:2546-50. 2005
    ..0 min with only one step. The purity and specific bioactivity of the purified lysozyme were found to be more than 93% and 70 245 U/mg, respectively...
  41. ncbi Comparison of protein adsorption isotherms and uptake rates in preparative cation-exchange materials
    C Chang
    Department of Chemical Engineering, University of Delaware, Newark 19716, USA
    J Chromatogr A 827:281-93. 1998
    ..Additional information is required to elucidate further the mechanisms of coupled diffusion and adsorption in stationary phases...
  42. ncbi Characterization and application of strong ion-exchange membrane adsorbers as stationary phases in high-performance liquid chromatography of proteins
    O W Reif
    , , Germany
    J Chromatogr A 654:29-41. 1993
    ..Appropriate conditions were defined for the separation of human serum and for the isolation of subtilisin Carlsberg and beta-galactosidase from cell culture supernatants...
  43. ncbi Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography
    Tomasz Mroczek
    Department of Pharmacognosy, Medical University, Lublin, Poland
    J Chromatogr A 949:249-62. 2002
    ..For the last three samples macrocyclic PAs (senecionine, senecionine-N-oxide. senkirkine) have been detected for the first time. Details of precision of the analyses are also included...
  44. ncbi Influence of column type and chromatographic conditions on the ion-exchange chromatography of immunoglobulins
    Y B Yang
    Separations Group, Inc, Hesperia, CA 92345, USA
    J Chromatogr A 743:171-80. 1996
    ..Significant differences in the chromatographic behavior (elution pattern, peak shape and selectivity) of the test samples are discussed in regard to the column type and the chromatographic conditions...
  45. ncbi Simplified in-line sample preparation for amino acid analysis in carbohydrate containing samples
    P Jandik
    Dionex Corporation, Research and Development, Sunnyvale, CA 94088-3603, USA
    J Chromatogr B Biomed Sci Appl 758:189-96. 2001
    ..99. The mean value of relative standard deviations from five replicates was 3.9%. The usefulness of the method is illustrated with two chromatograms of a carrot juice sample obtained before and after the in-line removal of carbohydrates...
  46. ncbi pH Transitions in ion-exchange systems: role in the development of a cation-exchange process for a recombinant protein
    Sanchayita Ghose
    Product Recovery, Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Biotechnol Prog 18:530-7. 2002
    ..The results from this study were applied to the cation-exchange step for a recombinant protein that was sensitive to pH excursions to help maintain activity of the protein during the purification process...
  47. ncbi Integrated strategy for selective expanded bed ion-exchange adsorption and site-specific protein processing using gene fusion technology
    Torbjörn Gräslund
    Department of Biotechnology, Royal Institute of Technology KTH, SCFAB, S 106 91, Stockholm, Sweden
    J Biotechnol 96:93-102. 2002
    ..The strategy also includes an integrated site-specific removal of the Z(basic) purification handle to yield a free target protein...
  48. pmc Volumetric interpretation of protein adsorption: ion-exchange adsorbent capacity, protein pI, and interaction energetics
    Hyeran Noh
    Department of Materials Science and Engineering, Huck Institute of Life Sciences and Materials Research Institute, The Pennsylvania State University, University Park, PA 16802, USA
    Biomaterials 29:2033-48. 2008
    ....
  49. ncbi Analysis of the physicochemical interactions between Clostridium difficile toxins and cholestyramine using liquid chromatography with post-column derivatization
    G P Palace
    Analytical Chemistry Department, GelTex Pharmaceuticals, Inc, 153 Second Avenue, Waltham, MA 02451, USA
    Biochim Biophys Acta 1546:171-84. 2001
    ..Binding to strong cation exchange resins (sulfonate-PHM) was not observed...
  50. ncbi [Multiple type I pseudohypoaldosteronism: neonatal management and outcome]
    M Cristina De Frutos Martínez
    Servicio de Neonatologia, Hospital Infantil La Paz, Universidad Autonoma de Madrid
    An Esp Pediatr 52:47-51. 2000
    ..The treatment consisted of salt and sodium bicarbonate supplements, restricted potassium intake, cation exchange resins and high fluid intake. During first year she was hospitalized for severe salt-losing crises...
  51. ncbi Identification of S-methylmethionine in Petit Manseng grapes as dimethyl sulphide precursor in wine
    N Loscos
    Dpto De Química Analítica Facultad de Ciencias Universidad de Zaragoza, C Pedro Cerbuna no 12, 50009 Zaragoza, Spain
    Anal Chim Acta 621:24-9. 2008
    ..SMM peak identification and quantification (401.2nmolmL(-1) relatively to norleucine used as internal standard) were carried out by comparison with commercial SMM...
  52. pmc Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets
    Thaned Pongjanyakul
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    AAPS PharmSciTech 6:E190-7. 2005
    ..DMP resinates were formed by a complexation of DMP and strong cation exchange resins, Dowex 50 W and Amberlite IRP69...
  53. ncbi On-line cation exchange for suppression of adduct formation in negative-ion electrospray mass spectrometry of nucleic acids
    C G Huber
    Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University, Innsbruck, Austria
    Anal Chem 70:5288-95. 1998
    ..2-20 microM with selected-ion monitoring. Finally, the on-line sample preparation system was evaluated for the mass spectrometric analysis of complex oligonucleotide mixtures...
  54. ncbi Preparation of phytate-removed deamidated soybean globulins by ion exchangers and characterization of their calcium-binding ability
    Hitomi Kumagai
    Department of Agricultural and Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa shi 252 8510, Japan
    J Agric Food Chem 50:172-6. 2002
    ..10 g/mL of CE-4 in a 0.2% soybean globulin solution for 6 h at 4 degrees C. The amount of calcium bound to the soybean globulins decreased with removal of the phytate but increased with deamidation...
  55. ncbi Formulation design of ranitidine hydrochloride to reduce its moisture absorption characteristics
    Shagufta Khan
    Department of Pharmaceutics, Institute of Pharmaceutical Education and Research, Borgaon Meghe Wardha, Maharashtra, India
    PDA J Pharm Sci Technol 63:226-33. 2009
    ..Drug resin complexes (DRCs) were prepared using the batch method with (i) two weak cation exchange resins, Polacrilex with exchangeable H+ and Polacrillin potassium; and (ii) a strong cation exchange resin;Sodium ..
  56. doi Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption
    Masahiro Takeyama
    Department of Paediatrics, Nara Medical University, Kashihara, Nara, Japan
    Br J Haematol 142:962-70. 2008
    ..Furthermore, iminodiacetate resin-treated plasma would be useful as a substrate for measuring the activity of these factors...
  57. ncbi Anion chromatography using on-line recycled eluents
    Takashi Yokoyama
    Department of Chemistry, Faculty of Science, Okayama University of Science, 1 1 Ridai cho, Okayama 700 0005, Japan
    J Chromatogr A 1089:82-6. 2005
    ..The performance of the anion chromatography, using on-line recycled eluents, was the same as that for normal anion chromatography under the same conditions...
  58. ncbi [13C] GC-C-IRMS analysis of methylboronic acid derivatives of glucose from liver glycogen after the ingestion of [13C] labeled tracers in rats
    Catherine Luengo
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, F 75005 Paris, France
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3638-44. 2009
    ..Hepatic glycogen was extracted, digested to glucose and purified on anion-cation exchange resins. After the optimization of methylboronic acid derivatization using GC-MS, [(13)C] enrichment of extracted ..
  59. ncbi Combined ion exchange treatment for removal of dissolved organic matter and hardness
    Jennifer N Apell
    Department of Environmental Engineering Sciences, University of Florida, P O Box 116450, Gainesville, FL 32611 6450, USA
    Water Res 44:2419-30. 2010
    ..Hardness ions can be removed with cation exchange resins, although typically using a fixed bed reactor at the end of a treatment train...
  60. doi Highly efficient removal of heavy metals by polymer-supported nanosized hydrated Fe(III) oxides: behavior and XPS study
    Bingjun Pan
    State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University, Nanjing 210093, PR China
    Water Res 44:815-24. 2010
    ..More attractively, the exhausted HFO-001 beads can be effectively regenerated by HCl-NaCl solution (pH 3) for repeated use without any significant capacity loss...
  61. ncbi Effect of phytate-removal and deamidation of soybean proteins on calcium absorption in the in situ rats
    Hitomi Kumagai
    Department of Agricultural and Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa shi 252 8510, Japan
    Biofactors 22:21-4. 2004
    ..As a result, PrDS retained their high calcium binding properties even after hydrolysis by digestive enzymes. In situ experiments showed that PrDS and their hydrolysates enhanced the calcium absorption from the intestine...
  62. doi Simple and rapid analytical method for detection of amino acids in blood using blood spot on filter paper, fast-GC/MS and isotope dilution technique
    Shuichi Kawana
    Department of Pediatrics, Shimane University School of Medicine, 89 1 En ya cho, Izumo, Shimane 693 8501, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3113-8. 2010
    ..These results indicate that this method provides a simple and rapid procedure for precise determination of amino acids in whole blood...
  63. doi Ammonium removal from anaerobic digester effluent by ion exchange
    T Wirthensohn
    Department of IFA Tulln, Institute for Environmental Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430 Tulln, Austria
    Water Sci Technol 60:201-10. 2009
    ..74 mg/l; Ca2+= 1.79 mg/l). The aim of this study was to remove this ammonium by ion exchange. Acidic gel cation exchange resins and clinoptilolite were tested in column experiments to evaluate their capacity, flow rates and pH...
  64. doi Control of plant diseases with secondary metabolite of Clitocybe nuda
    Jin Tong Chen
    Department of Plant Pathology, National Chung Hsing University, Taichung 402, Taiwan
    N Biotechnol 26:193-8. 2009
    ..It was also exchangeable by anion but not cation exchange resins, indicating that the inhibitor has a molecular weight between 1000 and 500, and negative charge on its ..
  65. pmc Ion exchange chromatography of monoclonal antibodies: effect of resin ligand density on dynamic binding capacity
    Ann Marie Hardin
    Genentech Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 1216:4366-71. 2009
    Dynamic binding capacity (DBC) of a monoclonal antibody on agarose based strong cation exchange resins is determined as a function of resin ligand density, apparent pore size of the base matrix, and protein charge...
  66. ncbi Coadsorption of trivalent metal ions and anions on strongly acidic cation-exchange resins by bridge bonding
    Takanori Matsuura
    Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa, Nagoya, 466 8555, Japan
    Anal Chem 80:9666-71. 2008
    ..These findings indicate that the bridge bonding of anions between the metal ions adsorbed on the resins of the higher exchange capacities plays a crucial role for the coadsorption. Some analytical implication was also discussed...
  67. doi Extraction of extracellular polymeric substances from extreme acidic microbial biofilms
    Angeles Aguilera
    Centro de Astrobiología INTA CSIC, Madrid, Spain
    Appl Microbiol Biotechnol 78:1079-88. 2008
    ..8 and Crown Ether cation exchange resins) were tested...
  68. doi Role of the ligand density in cation exchange materials for the purification of proteins
    Agnes Franke
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    J Chromatogr A 1217:2216-25. 2010
    The performance of functionalized materials, such as cation exchange resins, is dependent not only on the ligand type and ligand density, but also on the pore accessibility of the target molecule...
  69. ncbi Selection and evaluation of adsorbents for the removal of anionic surfactants from laundry rinsing water
    Natasja Schouten
    Wetsus, Centre for Sustainable Water Technology, Agora 1, PO Box 1113, 8900 CC Leeuwarden, The Netherlands
    Water Res 41:4233-41. 2007
    ..02-0.6 gLAS/g. Negatively charged materials, such as cation exchange resins or bentonite clay, have negligible adsorption capacities for LAS...
  70. pmc Formulation and In vitro Evaluation of Sustained Release Dosage Form with Taste Masking of Metformin Hydrochloride
    P K Bhoyar
    S K B College of Pharmacy, New Kamptee, Nagpur 441 002, India
    Indian J Pharm Sci 72:184-90. 2010
    ..Results showed that metformin HCl was successfully taste masked and formulated into a sustained dosage form as an alternative to the conventional tablet...
  71. ncbi Sample preparation and in-solution protease digestion of proteins for chromatography-based proteomic analysis
    Michael P Washburn
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Curr Protoc Protein Sci . 2008
    ..are directly loaded onto a microcapillary column packed sequentially with reversed-phase and strong cation exchange resins. Once digested protein samples are loaded onto the column, the column is placed in-line between a high-..
  72. doi Cadmium sorption characteristics of phosphorylated sago starch-extraction residue
    Masato Igura
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Nakacho, Koganei, Tokyo 184 8588, Japan
    J Hazard Mater 178:686-92. 2010
    ..2 mg g(-1), which is almost half the capacity of commercially available weakly acidic cation exchange resins. The phosphorylated residue could be reused several times, although cadmium sorption gradually decreased ..
  73. pmc NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Kidney Int 82:718-22. 2012
    ..01), and tubular atrophy (mild vs. severe disease; mean 54 vs. 164 μg uNGAL/g Cr, P<0.01). Monospecific assays of the NGAL monomer demonstrated a correlation with histology that typifies progressive, severe CKD...
  74. doi Similarities in effluent organic matter characteristics from Connecticut wastewater treatment plants
    Matthew L Quaranta
    University of Connecticut, Environmental Engineering Program, 261 Glenbrook Rd, Storrs, CT 06269, USA
    Water Res 46:284-94. 2012
    ..Little variation in EfOM characteristics was observed between the five wastewater treatment plants, suggesting that the characteristics of EfOM are similar, regardless of treatment plant design...
  75. doi Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins
    Chetan P Yewale
    Department of Pharmaceutics, MVP Samaj s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik, Maharashtra, India
    Pharm Dev Technol 18:367-76. 2013
    ..Masking of bitter taste of drug for better patient compliance...
  76. doi Electrodialytic membrane suppressors for ion chromatography make programmable buffer generators
    Yongjing Chen
    Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019 0065, USA
    Anal Chem 84:67-75. 2012
    ..We believe that this approach will be of value for the generation of eluents in the separation of proteins and other biomolecules and in online process titrations...
  77. doi Post-processing via cation exchange cartridges: versatile options
    F Rösch
    Institute of Nuclear Chemistry, Johannes Gutenberg University, Mainz, Germany
    Recent Results Cancer Res 194:33-42. 2013
    ..Post-processing of (68)Ge/(68)Ga generators using cation exchange resins provides chemically and radiochemically pure (68)Ga with 97±2% within less than 4 min, with (68)Ge almost ..
  78. doi Separation of patatins and protease inhibitors from potato fruit juice with clay minerals as cation exchangers
    Kathrin Ralla
    Institut fur Biotechnologie, FG Bioverfahrenstechnik, Technische Universitat Berlin, Berlin, Germany
    J Sep Sci 35:1596-602. 2012
    ..Additionally, the content of glycoalkaloids naturally occurring in potatoes is significantly reduced in a single step together with the separation of the patatins and the protease inhibitors...
  79. ncbi Maturation of a key resource - the germanium-68/gallium-68 generator: development and new insights
    F Roesch
    Institute of Nuclear Chemistry, University of Mainz, D 55128 Mainz, Germany
    Curr Radiopharm 5:202-11. 2012
    ....
  80. doi Improving selectivity in multimodal chromatography using controlled pH gradient elution
    Melissa A Holstein
    Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    J Chromatogr A 1233:152-5. 2012
    ..8 to 5.5 is shown to be able to resolve the proteins. This work provides proof of concept for the use of pH gradients in multimodal chromatography and sets the stage for future applications...
  81. ncbi Removal of chromium(III) from aqueous solutions using Lewatit S 100: the effect of pH, time, metal concentration and temperature
    Fethiye Gode
    Faculty of Art and Science, Department of Chemistry, Suleyman Demirel University, 32260 Isparta, Turkey
    J Hazard Mater 136:330-7. 2006
    ..The rise in temperature caused a slight increase in the value of the equilibrium constant (K(c)) for the sorption of Cr(III) ion for both resins...
  82. doi Comparison of magnetic carboxymethyl chitosan nanoparticles and cation exchange resin for the efficient purification of lysine-tagged small ubiquitin-like modifier protease
    Junhua Li
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
    J Chromatogr B Analyt Technol Biomed Life Sci 907:159-62. 2012
    ....
  83. ncbi Transbilayer movement of dipalmitoylphosphatidylcholine in proteoliposomes reconstituted from detergent extracts of endoplasmic reticulum. Kinetics of transbilayer transport mediated by a single flippase and identification of protein fractions enriched in
    Sathyanarayana N Gummadi
    Department of Biochemistry, University of Wisconsin Madison, 53706 1569, USA
    J Biol Chem 277:25337-43. 2002
    ..Preliminary purification steps indicated that flippase activity could be enriched approximately 15-fold by sequential adsorption of the detergent extract onto anion and cation exchange resins.
  84. doi Hb Belleville [beta 10(A7)Ala-->Thr] affects the determination of Hb A1c by routine cation exchange high performance liquid chromatography
    Jonathan P Williams
    Department of Chemistry, University of Warwick, Coventry, Warwickshire, UK
    Hemoglobin 33:45-50. 2009
    ..9 and 12.4%, respectively) agreed with the sum of the two peaks (12.1%) in the HPLC trace. Similarly, Hb Belleville was detected and identified in another Caucasian, also from Yorkshire, with normal Hb A(1c)...
  85. doi Efficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coli
    Yin Jue Wang
    National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
    Int J Pharm 386:156-64. 2010
    ..These studies demonstrated the feasibility of PEGylating rh-ngEpo as a promising way for the development of new Epo drugs...
  86. doi Full automation of (68)Ga labelling of DOTA-peptides including cation exchange prepurification
    M Ocak
    Clinical Department of Nuclear Medicine, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Appl Radiat Isot 68:297-302. 2010
    ..This resulted in a high labelling efficiency of DOTA-peptides at high specific activity (SA) with short synthesis times...
  87. ncbi Extraction of metal cations by polyterephthalamide microcapsules containing a poly(acrylic acid) gel
    A Laguecir
    Ecole de Chimie, Polymères et Matériaux, CNRS UMR 7512, Strasbourg, France
    J Microencapsul 19:17-28. 2002
    ..The extractabilities of Cu(II), Ni(II), Co(II) and Zn(II) into PAA-CAPS were examined. The stripping of the various cations can be promoted in diluted hydrochloric acid solutions...
  88. ncbi Comparison of adsorption equilibrium of fructose, glucose and sucrose on potassium gel-type and macroporous sodium ion-exchange resins
    C Nobre
    IBB Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Anal Chim Acta 654:71-6. 2009
    ..Based on the selectivity results, K+ gel-type resin seems to be the best choice for the separation of fructose, glucose and sucrose, at 25 degrees C...
  89. doi Influence of soil properties on the sorption and retention of cadmium, copper and lead, separately and together, by 20 soil horizons: comparison of linear regression and tree regression analyses
    F A Vega
    Departamento de Bioloxía Vexetal e Ciencia do Solo, Facultade de Bioloxia, Universidade de Vigo, Lagoas, Marcosende, 36310 Vigo, Pontevedra, Spain
    J Hazard Mater 174:522-33. 2010
    ....
  90. ncbi Sulfoacylated macro-porous polystyrene-divinylbenzene low-capacity cation exchanger selective for amino acids
    Yukio Yokoyama
    Department of Analytical Chemistry, Faculty of Engineering, Yokohama National University, Hodogaya, Japan
    Anal Sci 18:59-63. 2002
    ..e., acidic, neutral, hydrophobic, and basic groups. The results provided fundamental data for constructing gradient elution systems required for the simultaneous separation of protein amino acids...
  91. ncbi Syncope caused by iatrogenic hyperkalemia
    Giuseppe Giancaspro
    Department of Emergency and Urgency, Sapienza University, Azienda Policlinico Umberto I, Rome, Italy
    J Cardiovasc Med (Hagerstown) 10:72-4. 2009
    ..We report a case of an 87-year-old woman with a clinical history of chronic angiotensin-receptor blocker consumption that led her to dangerous bradyarrhythmia, cardiogenic syncope, and risk of sudden cardiac death...
  92. pmc Novel poly-dopamine adhesive for a halloysite nanotube-Ru(bpy)(3)2+ electrochemiluminescent sensor
    Bo Xing
    Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 4:e6451. 2009
    ..The results indicate that halloysite nanotubes have a high loading capacity for Ru(bpy)(3) (2+) and that dopamine is suitable for the preparation of modified electrodes...
  93. ncbi Simian foamy virus vectors. Preparation and use
    Jeonghae Park
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainsville, FL, USA
    Methods Mol Med 69:319-33. 2002
  94. ncbi Suitability of Smopex-102 cation-exchange fiber for analytical purposes and drug monitoring
    J Karppi
    Laboratory Centre, Kuopio University Hospital, Finland
    Pharmazie 64:14-8. 2009
    ..g. serum) liquid solutions for subsequent monitoring and evaluation. However, the drug release solution and release time must be optimized more precisely in order to validate described sample preparation method for each basic drug...
  95. doi Hypothesis: a simple algorithm to distinguish between hypoaldosteronism and renal aldosterone resistance in patients with persistent hyperkalemia
    William R Adam
    University of Melbourne, School of Rural Health, Shepparton, Victoria, Australia
    Nephrology (Carlton) 13:459-64. 2008
    ..defined which would help identify patients with hyperkalemia owing to suboptimal levels of aldosterone, thereby validating treatment with 9-alpha-fluhydrocortisone, instead of cation exchange resins, if more conservative treatment fails.
  96. doi Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materials
    Christian V Hoffmann
    Department of Analytical Chemistry and Food Chemistry, Christian Doppler Laboratory for Molecular Recognition Materials, University of Vienna, Wahringer Strasse 38, A 1090, Vienna, Austria
    Anal Bioanal Chem 393:1257-65. 2009
    ..Furthermore, both SCX materials allowed successful separation of C9-epi and 10,11-didehydro derivatives from their respective educts in an application in synthetic Cinchona alkaloid chemistry...
  97. ncbi [Determination of 4-aminobutyric acid in pumpkin powder by high performance liquid chromatography]
    H W Liu
    Research Institute of Forest Ecology and Environmental, Chinese Academy of Forestry, Beijing 100091, China
    Se Pu 19:532-3. 2001
    ..The retention time of 4-aminobutyric acid was 34.77 minutes. The average recovery was 99% and the coefficient of variation was 1.35%. This method is simple, rapid and sensitive...
  98. ncbi Separation of vanadium isotopes by ion-exchange chromatography
    Yong Hong Zhang
    Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 0 okayama, Meguro ku, Tokyo 152 8550, Japan
    J Chromatogr A 989:175-82. 2003
    ..Citrate may be better than the other tested systems for the vanadium isotope separation...
  99. doi Analytical and preparative separation of PEGylated lysozyme for the characterization of chromatography media
    Anna Moosmann
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Chromatogr A 1217:209-15. 2010
    ..TSKgel SP-5PW and Toyopearl GigaCap S-650M showed the best performance of all tested cation exchange resins, and the separation of PEGylated lysozyme could be also scaled up to semi-preparative level...
  100. doi Application of displacement chromatography for the analysis of a lipid raft proteome
    Maria Trusch
    Department of Clinical Chemistry, University Medical Center Hamburg Eppendorf, Campus Forschung, Martinistr 52, D 20246 Hamburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:309-14. 2010
    ..The majority of identified proteins were membrane proteins. In sum, our results demonstrate that DC is a suitable alternative to gradient elution separations for the identification of proteins via a multidimensional LC-MS approach...
  101. ncbi Lateral interaction between electrostatically adsorbed and covalently immobilized proteins on the surface of cation-exchange sorbents
    C K Ratnayake
    PerSeptive Biosystems Inc, Framingham, MA 01701, USA
    J Chromatogr A 743:25-32. 1996
    ..It was concluded that these phenomena are due to lateral interactions between immobilized proteins and analyte proteins subsequent to electrostatic adsorption of the analyte on the underivatized surface of ion-exchange sorbents...

Research Grants20

  1. Synthetic Peptide Consensus Sequence Vaccine Development
    Robert Hodges; Fiscal Year: 2005
    ..abstract_text> ..
  2. Bone Quality and Mechanical Competence In Chronic Kidney Disease
    Thomas Nickolas; Fiscal Year: 2008
    ..PUBLIC HEALTH RELEVANCE: This study is highly relevant to public health, as fracture risk and its associated morbidity and mortality are exceedingly high in CKD patients and CKD and osteoporosis are highly coprevalent. ..
  3. HPLC OF PEPTIDES AND PROTEINS
    Robert Hodges; Fiscal Year: 2001
    ..Such work has major implications for the de novo design of more effective antimicrobial agents. ..
  4. Alpbach Workshop:Coiled-Coils, Collagen/Co-proteins
    Robert Hodges; Fiscal Year: 2005
    ..abstract_text> ..
  5. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2006
    ..Proteomics is a multidisciplinary research activity wherein separation science (including multidimensional HPLC and CE) and mass spectrometry will continue to play pivotal roles. ..
  6. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2007
    ..Proteomics is a multidisciplinary research activity wherein separation science (including multidimensional HPLC and CE) and mass spectrometry will continue to play pivotal roles. ..
  7. Design of New Antimicrobials
    Robert Hodges; Fiscal Year: 2008
    ..S. Thus, there is an economic incentive to adopt novel antibiotics. ..
  8. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2009
    ..The development of these methods will have a major impact on proteomics as well. ..
  9. Design of New Antimicrobials
    Robert Hodges; Fiscal Year: 2009
    ..S. Thus, there is an economic incentive to adopt novel antibiotics. ..
  10. Design of New Antimicrobials
    Robert S Hodges; Fiscal Year: 2010
    ..S. Thus, there is an economic incentive to adopt novel antibiotics. ..
  11. Analytical Ultracentrifuge Purchase
    Robert Hodges; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2005
    ..Proteomics is a multidisciplinary research activity wherein separation science (including multidimensional HPLC and CE) and mass spectrometry will continue to play pivotal roles. ..
  13. HPLC OF PEPTIDES AND PROTEINS
    Robert Hodges; Fiscal Year: 2002
    ..Such work has major implications for the de novo design of more effective antimicrobial agents. ..
  14. Synthetic Peptide Consensus Sequence Vaccine Development
    Robert Hodges; Fiscal Year: 2002
    ..abstract_text> ..
  15. LC/MS/MS Purchase
    Robert Hodges; Fiscal Year: 2003
    ..A. Sorkin) Design of peptide analogs/mimetic of the hormones bradykinin and substance P and cloning of the substance P receptor in rat brain. (J. M. Stewart) ..
  16. HPLC OF PEPTIDES AND PROTEINS
    Robert Hodges; Fiscal Year: 2003
    ..Such work has major implications for the de novo design of more effective antimicrobial agents. ..
  17. Synthetic Peptide Consensus Sequence Vaccine Development
    Robert Hodges; Fiscal Year: 2003
    ..abstract_text> ..
  18. Synthetic Peptide Consensus Sequence Vaccine Development
    Robert Hodges; Fiscal Year: 2004
    ..abstract_text> ..
  19. HPLC and CE of Peptides and Proteins
    Robert Hodges; Fiscal Year: 2004
    ..Proteomics is a multidisciplinary research activity wherein separation science (including multidimensional HPLC and CE) and mass spectrometry will continue to play pivotal roles. ..
  20. HPLC and CE of Peptides and Proteins
    Robert S Hodges; Fiscal Year: 2010
    ..The development of these methods will have a major impact on proteomics as well. ..