siderophores

Summary

Summary: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Top Publications

  1. pmc Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
  2. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
  3. pmc Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
  4. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
  5. pmc HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
  6. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
  7. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
  8. doi Chemistry and biology of siderophores
    Robert C Hider
    Division of Pharmaceutical Science, King s College, London, SE1 9NH, UK
    Nat Prod Rep 27:637-57. 2010
  9. pmc Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B 16, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Eukaryot Cell 7:20-7. 2008
  10. doi Iron uptake and metabolism in pseudomonads
    Pierre Cornelis
    Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium
    Appl Microbiol Biotechnol 86:1637-45. 2010

Detail Information

Publications325 found, 100 shown here

  1. pmc Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
    ..Due to the key role of many siderophores during virulence, coevolution led to sophisticated strategies of siderophore neutralization by mammals and (re)..
  2. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..Furthermore, A. fumigatus utilizes two intracellular siderophores, ferricrocin and hydroxyferricrocin, to store iron...
  3. pmc Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
    ..membrane transporter system, fbpABC, that is required for the utilization of multiple structurally distinct siderophores including alcaligin, enterobactin, ferrichrome, and desferrioxamine B...
  4. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
    ..Pathways positively affected by HapX include production of the ribotoxin AspF1 and siderophores, which are known virulence determinants...
  5. pmc HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
    ..Overall, these results indicated that C. neoformans employs multiple strategies for iron acquisition during infection...
  6. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
    ..Here we report that NGAL tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent ..
  7. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
    Pyoverdines are a group of structurally related siderophores produced by fluorescent Pseudomonas species...
  8. doi Chemistry and biology of siderophores
    Robert C Hider
    Division of Pharmaceutical Science, King s College, London, SE1 9NH, UK
    Nat Prod Rep 27:637-57. 2010
    b>Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment...
  9. pmc Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B 16, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Eukaryot Cell 7:20-7. 2008
  10. doi Iron uptake and metabolism in pseudomonads
    Pierre Cornelis
    Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium
    Appl Microbiol Biotechnol 86:1637-45. 2010
    ..Like for other bacteria, iron is a key nutrient for pseudomonads. The fluorescent pseudomonads produce siderophores, the best known being the fluorescent high-affinity peptidic pyoverdines...
  11. doi Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii
    Daniel L Zimbler
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Biometals 22:23-32. 2009
    ..Unexpectedly, the ability of this pathogen to acquire iron depends on the expression of a SecA protein secretion function, which has not been associated with iron acquisition in bacteria...
  12. pmc Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron
    Peter Hortschansky
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
    EMBO J 26:3157-68. 2007
    ..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
  13. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
    ..In many cases, this involves the secretion and internalisation of extracellular ferric chelators called siderophores. Ferrous iron can also be directly imported by the G protein-like transporter, FeoB...
  14. pmc An extracytoplasmic function sigma factor-mediated cell surface signaling system in Pseudomonas syringae pv. tomato DC3000 regulates gene expression in response to heterologous siderophores
    Eric Markel
    United States Department of Agriculture Agricultural Research Service, Ithaca, New York 14853, USA
    J Bacteriol 193:5775-83. 2011
    ..syringae pyoverdine cluster. Additionally, we identified siderophores that induce the activity of PSPTO_1203 and used this information to investigate the functional components of ..
  15. doi Secretion, but not overall synthesis, of catecholate siderophores contributes to virulence of extraintestinal pathogenic Escherichia coli
    Mélissa Caza
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Mol Microbiol 80:266-82. 2011
    Extraintestinal pathogenic Escherichia coli (ExPEC) use siderophores to sequester iron during infection. Enterobactin and salmochelins are catecholate siderophores produced by some ExPEC strains and other pathogenic enterobacteria...
  16. pmc Loihichelins A-F, a suite of amphiphilic siderophores produced by the marine bacterium Halomonas LOB-5
    Vanessa V Homann
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    J Nat Prod 72:884-8. 2009
    A suite of amphiphilic siderophores, loihichelins A-F, were isolated from cultures of the marine bacterium Halomonas sp. LOB-5...
  17. pmc The phytopathogen Pseudomonas syringae pv. tomato DC3000 has three high-affinity iron-scavenging systems functional under iron limitation conditions but dispensable for pathogenesis
    Alexander M Jones
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    J Bacteriol 193:2767-75. 2011
    High-affinity iron scavenging through the use of siderophores is a well-established virulence determinant in mammalian pathogenesis. However, few examples have been reported for plant pathogens...
  18. pmc The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 12:1035-41. 2010
    ..To ensure an adequate supply with iron, Aspergillus fumigatus employs extra- and intracellular siderophores (low-molecular mass iron chelators), which are of importance for fungal growth in particular during iron ..
  19. ncbi Iron and fungal pathogenesis: a case study with Cryptococcus neoformans
    Won Hee Jung
    The Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Cell Microbiol 10:277-84. 2008
    ..neoformans is in host tissue. Achieving these goals may contribute to an understanding of the notable predilection of the fungus for the mammalian central nervous system...
  20. pmc Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis
    Kathryn E Bushley
    Department of Plant Pathology and Plant Microbe Biology, 334 Plant Science Building, Cornell University, Ithaca, NY 14853, USA
    BMC Evol Biol 8:328. 2008
    Most filamentous ascomycete fungi produce high affinity iron chelators called siderophores, biosynthesized nonribosomally by multimodular adenylating enzymes called nonribosomal peptide synthetases (NRPSs)...
  21. pmc The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans
    Martin Eisendle
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Eukaryot Cell 5:1596-603. 2006
    ....
  22. pmc Role of the Fur regulon in iron transport in Bacillus subtilis
    Juliane Ollinger
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 188:3664-73. 2006
    ..the intact bacillibactin siderophore is restored (by the introduction of a functional sfp gene) or exogenous siderophores are provided...
  23. pmc OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints
    Takahiro Aoyama
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Mol Biol 70:681-92. 2009
    ..These results suggest that OsYSL18 is an iron-phytosiderophore transporter involved in the translocation of iron in reproductive organs and phloem in joints...
  24. pmc Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus
    Anja Wallner
    Biocenter, Medical University of Innsbruck, Austria
    Appl Environ Microbiol 75:4194-6. 2009
    ..Thus, ferricrocin represents the first intracellular iron transporter identified in any organism...
  25. ncbi Chemical aspects of siderophore mediated iron transport
    Hakim Boukhalfa
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Biometals 15:325-39. 2002
    ..Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells...
  26. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..Some invading bacteria respond by producing specific iron chelators-siderophores-that remove the iron from the host sources...
  27. ncbi Cooperation and competition in pathogenic bacteria
    Ashleigh S Griffin
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Nature 430:1024-7. 2004
    ..The cooperative trait that we examine is the production of siderophores, iron-scavenging agents, in the pathogenic bacterium Pseudomonas aeruginosa...
  28. pmc SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin
    Michael Blatzer
    Division of Molecular Biology, Biocenter, Fritz Pregl Str 3, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Appl Environ Microbiol 77:4959-66. 2011
    The opportunistic fungal pathogen Aspergillus fumigatus produces four types of siderophores, low-molecular-mass iron chelators: it excretes fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and accumulates ferricrocin (..
  29. doi New roles for bacterial siderophores in metal transport and tolerance
    Isabelle J Schalk
    UMR7242, University of Strasbourg CNRS, ESBS, Blvd Sebastien Brant, F 67413 Illkirch, Strasbourg, France
    Environ Microbiol 13:2844-54. 2011
    b>Siderophores are chelators with extremely strong affinity for ferric iron and are best known for their capacity to feed microorganisms with this metal...
  30. ncbi Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex
    A Gotschlich
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Germany
    Syst Appl Microbiol 24:1-14. 2001
    ..All strains were also screened for the production of extracellular lipase, chitinase, protease, and siderophores. However, no correlation between the AHL production and the synthesis of these exoproducts was apparent...
  31. ncbi Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity
    Sandra Matthijs
    Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Building E, Pleinlaan 2, 1050 Brussels, Belgium
    Environ Microbiol 9:425-34. 2007
    Under conditions of iron limitation Pseudomonas fluorescens ATCC 17400 produces two siderophores, pyoverdine, and a second siderophore quinolobactin, which itself results from the hydrolysis of the unstable molecule 8-hydroxy-4-methoxy-2-..
  32. doi Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Roma, Italy
    Res Microbiol 162:279-84. 2011
    ..The results demonstrated that all A. baumannii isolates tested share the coding potential for two endogenous siderophores, a heme-acquisition and a ferrous iron-uptake system...
  33. ncbi Siderophore-mediated iron transport in Bacillus subtilis and Corynebacterium glutamicum
    Emily A Dertz
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 1460, USA
    J Biol Inorg Chem 11:1087-97. 2006
    ..Although both are triscatecholamide trilactones, the structural differences of these two siderophores result in opposite metal chiralities, different affinity for ferric ion, and dissimilar iron transport ..
  34. ncbi The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis
    Graeme L Card
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Biol Chem 280:13978-86. 2005
    ....
  35. pmc Microbial siderophores exert a subtle role in Arabidopsis during infection by manipulating the immune response and the iron status
    Alia Dellagi
    Laboratoire des Interactions Plantes Pathogènes, UMR 217, INRA AgroParisTech Université Pierre et Marie Curie, 75231 Paris Cedex 05, France
    Plant Physiol 150:1687-96. 2009
    b>Siderophores (ferric ion chelators) are secreted by organisms in response to iron deficiency...
  36. pmc Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents
    Marvin J Miller
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Biometals 22:61-75. 2009
    ..and active transport relies on the biosyntheses and use of microbe-selective iron-chelating compounds called siderophores. Our studies, and those of others, demonstrate that siderophores and analogs can be used for iron transport-..
  37. ncbi Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005
    ..transport capabilities for utilizing plant-derived compounds, the apparent ability to use a diversity of iron siderophores, detoxification systems to protect from oxidative stress, and the lack of a type III secretion system and ..
  38. ncbi Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport
    Caleb W Dorsey
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Microbiology 149:1227-38. 2003
    ..pestis phosphopantetheinyl transferase, all of them involved in the assembly and utilization of catechol siderophores in other bacteria, were found next to the dhbACEB locus. This A...
  39. pmc Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization
    Lena H Hwang
    Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 4:e1000044. 2008
    ..H. capsulatum acquires iron through the action of ferric reductases and the production of siderophores, but the genes responsible for these activities and their role in virulence have not been determined...
  40. ncbi A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
    Gregory L Challis
    Department of Chemistry, Warwick University, Coventry CV4 7AL, UK
    Chembiochem 6:601-11. 2005
  41. doi Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus
    Johnson Cheung
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mol Microbiol 74:594-608. 2009
    b>Siderophores are iron-scavenging molecules produced by many microbes. In general, they are synthesized using either non-ribosomal peptide synthetase (NRPS) or NRPS-independent siderophore (NIS) pathways...
  42. pmc Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores
    A H T Hissen
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Infect Immun 72:1402-8. 2004
    ..fumigatus. In human serum, all of the monoferric transferrin was converted to apoTf within 8 h. Siderophores were secreted by A. fumigatus after 8 h of growth in MEM-serum and 12 h in MEM-holoTf...
  43. ncbi Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria
    Michelle A Parent
    Department of Veterinary and Animal Sciences, Paige Laboratory, University of Massachusetts, Amherst, MA 01003, USA
    Microb Pathog 32:239-48. 2002
    b>Siderophores are low molecular weight molecules that allow bacteria to acquire iron from host cell proteins. 2,3-dihydroxybenzoic acid (DHBA) is the only known siderophore produced by the intracellular pathogen Brucella abortus...
  44. ncbi How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events
    Michael L Vasil
    University of Colorado at Denver and Health Sciences Center, 12800 E 19th Avenue RC 1 North P18 9127, Microbiology Mail Stop 8333, P O Box 6511, Aurora, CO 80045, USA
    Biometals 20:587-601. 2007
    ..g., expression and utilization of siderophores) or of iron-regulated genes involved in virulence (e.g., toxins)...
  45. doi The role of siderophores in iron acquisition by photosynthetic marine microorganisms
    Brian M Hopkinson
    Department of Geosciences, Princeton University, NJ 08544, USA
    Biometals 22:659-69. 2009
    ..Neither group appears to produce siderophores, although some coastal cyanobacteria do...
  46. ncbi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
    ..However, molecular details of how bacteria activate HIF-1 remain unclear. Here, we pursued the role of bacterial siderophores in HIF-1 activation during infection with Enterobacteriaceae.
  47. ncbi SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans
    H Oberegger
    Department of Microbiology, Medical School, University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria
    Mol Microbiol 41:1077-89. 2001
    Under conditions of low iron availability, most fungi excrete siderophores in order to mobilize extracellular iron...
  48. pmc Marine amphiphilic siderophores: marinobactin structure, uptake, and microbial partitioning
    Jennifer S Martinez
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106 9510, USA
    J Inorg Biochem 101:1692-8. 2007
    Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation...
  49. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
    ..By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, ..
  50. pmc Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli
    Rebecca E Watts
    Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Infect Immun 80:333-44. 2012
    ..Here, we utilize ABU E. coli strain 83972 as a model to dissect the contribution of siderophores to iron acquisition, growth, fitness, and colonization of the urinary tract. We show that E...
  51. ncbi Separation and detection of siderophores produced by marine bacterioplankton using high-performance liquid chromatography with electrospray ionization mass spectrometry
    Paul McCormack
    School of Environmental Sciences, Plymouth Environmental Research Center, University of Plymouth, Plymouth, PL4 8AA, UK
    Anal Chem 75:2647-52. 2003
    ..ionization mass spectrometry was applied to the detection of the iron(III) complexes of the hydroxamate siderophores rhodotoluric acid, deferrioxamine B, and deferrichrome...
  52. ncbi Evaluation of the siderophores production by Pseudomonas aeruginosa PSS
    María Elena Díaz de Villegas
    Dpto de Bioquímica, Cuban Institute for Research on Sugar Cane by Products Vía Blanca 804 y Carretera Central, P O Box 4026, La Habana, Cuba
    Rev Latinoam Microbiol 44:112-7. 2002
    b>Siderophores are compounds secreted under low iron stress, that act as a specific ferric iron chelate agents and due to their potentialities in the biological control of phytopathogenic fungi and bacteria, their study has been stimulated ..
  53. pmc Characterization of an iroBCDEN gene cluster on a transmissible plasmid of uropathogenic Escherichia coli: evidence for horizontal transfer of a chromosomal virulence factor
    Liisa Johanna Sorsa
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany
    Infect Immun 71:3285-93. 2003
    ..fepA cir fiu aroB mutant, IroN, but not IroBCDE, mediated the utilization of structurally related catecholate siderophores, including 2,3-dihydroxybenzoyl-L-serine, 2,3-dihydroxybenzoyl-D-ornithine, 2,3-dihydroxybenzoic acid, and ..
  54. pmc ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response
    G Marcela Rodriguez
    TB Center, The Public Health Research Institute, Newark, New Jersey 07103, USA
    Infect Immun 70:3371-81. 2002
    ....
  55. ncbi Molecular mechanisms of iron uptake in fungi
    Daniel J Kosman
    Department of Biochemistry, 140 Farber Hall, The University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Mol Microbiol 47:1185-97. 2003
    ..The integration of these multiple uptake mechanisms and their regulation into over-all iron homeostasis in yeast concludes this brief review...
  56. pmc 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Nucl Med 51:639-45. 2010
    ..uses a specific and highly efficient iron uptake mechanism based on iron-complexing ferric ion Fe(III) siderophores, which are a requirement for A. fumigatus virulence...
  57. pmc In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nucl Med Biol 39:361-9. 2012
    b>Siderophores are low-molecular-mass iron chelators serving as iron transporters for almost all bacteria, fungi and some plants...
  58. ncbi Hydroxamate siderophores: occurrence and importance in the Atlantic Ocean
    Edward Mawji
    School of Ocean and Earth Science, National Oceanography Centre, University of Southampton, Southampton SO14 3ZH, United Kingdom
    Environ Sci Technol 42:8675-80. 2008
    b>Siderophores are chelates produced by bacteria as part of a highly specific iron uptake mechanism. They are thought to be important in the bacterial acquisition of iron in seawater and to influence iron biogeochemistry in the ocean...
  59. pmc Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
    T Verne Lee
    AgResearch Structural Biology Laboratory, School of Biological Sciences, University of Auckland, Auckland 1142, New Zealand
    J Biol Chem 285:2415-27. 2010
    ..Thus, this new structure will provide a basis for improving prediction methods for eukaryotic NRPS enzymes that play important and diverse roles in the biology of fungi...
  60. pmc The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain
    Michelle B Ryndak
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 225 Warren Street, Newark, New Jersey 07103, USA
    J Bacteriol 192:861-9. 2010
    ..have evolved various strategies including the synthesis and secretion of high-affinity iron chelators known as siderophores. The siderophores produced and secreted by Mycobacterium tuberculosis, exomycobactins, compete for iron with ..
  61. doi Iron acquisition with the natural siderophore enantiomers pyochelin and enantio-pyochelin in Pseudomonas species
    Zeb A Youard
    Département de Microbiologie Fondamentale, Universite de Lausanne, Bâtiment Biophore, Lausanne, Switzerland
    Biometals 24:513-22. 2011
    ..Both siderophores promote growth of the producer organism during iron limitation and induce the expression of their biosynthesis ..
  62. pmc Lipocalin 2 is protective against E. coli pneumonia
    Hong Wu
    Granulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark
    Respir Res 11:96. 2010
    ..coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs...
  63. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
    ..we discuss the most recent findings on the mechanisms involved in maintaining iron homeostasis with a focus on siderophores, low-molecular-mass iron chelators, employed for iron uptake and storage...
  64. pmc Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation
    Jung Yeop Lee
    Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e20777. 2011
    Bacillus anthracis produces two catecholate siderophores, petrobactin and bacillibactin, under iron-limited conditions...
  65. pmc Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system
    Hiroaki Naka
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Environ Microbiol 10:265-77. 2008
    ..Our results underscore the importance of the anguibactin system in the survival of V. anguillarum 775 under conditions of iron limitation...
  66. pmc Role of porins in iron uptake by Mycobacterium smegmatis
    Christopher M Jones
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, Alabama 35294, USA
    J Bacteriol 192:6411-7. 2010
    Many bacteria rely on siderophores to extract iron from the environment. However, acquisition of iron-loaded siderophores is dependent on high-affinity uptake systems that are not produced under high-iron conditions...
  67. pmc Plasmid- and chromosome-encoded redundant and specific functions are involved in biosynthesis of the siderophore anguibactin in Vibrio anguillarum 775: a case of chance and necessity?
    Alejandro F Alice
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 187:2209-14. 2005
    ..We also identified in this cluster a chromosomal angA gene that is essential in anguibactin biosynthesis...
  68. pmc Chemistry of marine ligands and siderophores
    Julia M Vraspir
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    Ann Rev Mar Sci 1:43-63. 2009
    ..In the case of iron, siderophores have been identified and structurally characterized...
  69. doi TonB-dependent outer-membrane proteins and siderophore utilization in Pseudomonas fluorescens Pf-5
    Sierra L Hartney
    Department of Botany and Plant Pathology, Oregon State University, 2082 Cordley Hall, Corvallis, OR 97331, USA
    Biometals 24:193-213. 2011
    The soil bacterium Pseudomonas fluorescens Pf-5 produces two siderophores, a pyoverdine and enantio-pyochelin, and its proteome includes 45 TonB-dependent outer-membrane proteins, which commonly function in uptake of siderophores and ..
  70. ncbi The role of iron in plant host-pathogen interactions
    D Expert
    Laboratoire de Pathologie Végétale, INRA INA P G, Paris, France
    Trends Microbiol 4:232-7. 1996
    ..These studies could lead to the development of new control strategies against microbial infections of plants...
  71. pmc Metalloregulation in Bacillus subtilis: isolation and characterization of two genes differentially repressed by metal ions
    L Chen
    Section of Microbiology, Cornell University, Ithaca, New York 14853
    J Bacteriol 175:5428-37. 1993
    ..Mutation of the putative iron box for gene mrgC leads to partial derepression in iron-replete medium...
  72. pmc Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections
    M B Visser
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, Alberta T2N 4N1, Canada
    Infect Immun 72:2850-7. 2004
    ..Pc715jfptA::tp and Pc715jorbA::tp produced smaller amounts of their corresponding siderophores. Both Pc715jorbA::tp and Pc715jfptA::tp were able to grow in iron starvation conditions in vitro...
  73. pmc Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans
    Martin Eisendle
    Department of Molecular Biology, Medical University of Innsbruck, Austria
    Eukaryot Cell 3:561-3. 2004
    Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH...
  74. ncbi Pseudomonas fluorescens CHA0 produces enantio-pyochelin, the optical antipode of the Pseudomonas aeruginosa siderophore pyochelin
    Zeb A Youard
    Département de Microbiologie Fondamentale, Universite de Lausanne, Bâtiment Biophore, Quartier UNIL Sorge, CH 1015 Lausanne, Suisse
    J Biol Chem 282:35546-53. 2007
    ..aeruginosa siderophore pyochelin. Enantio-pyochelin was chemically synthesized and confirmed to be active in CHA0. Its potential biosynthetic pathway in CHA0 is discussed...
  75. ncbi Marine siderophores and microbial iron mobilization
    Alison Butler
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93111 9510, USA
    Biometals 18:369-74. 2005
    ..Like terrestrial bacterial, bacteria isolated from open ocean water often produce siderophores, which are low molecular weight chelating ligands that facilitate the microbial acquisition of iron...
  76. ncbi Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis
    M Seifert
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Immunobiology 213:767-78. 2008
    ..fumigatus. This fungus synthesizes three major siderophores. It excretes triacetylfusarinine C to capture iron, while it accumulates ferricrocin and hydroxyferricrocin for ..
  77. ncbi Iron nutrition and physiological responses to iron stress in Nitrosomonas europaea
    Xueming Wei
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331 2902, USA
    Arch Microbiol 186:107-18. 2006
    ..europaea was able to assimilate up to 70% of the available Fe in the medium even though it is unable to produce siderophores. Addition of exogenous siderophores to Fe-limited medium increased growth (final cell mass)...
  78. pmc The siderophore pyoverdine of Pseudomonas syringae pv. tabaci 6605 is an intrinsic virulence factor in host tobacco infection
    Fumiko Taguchi
    The Graduate School of Natural Science and Technology, Okayama University, Tsushima naka 1 1 1, Okayama 700 8530, Japan
    J Bacteriol 192:117-26. 2010
    ..tabaci 6605 are indispensable for virulence in host tobacco infection and that AHL may negatively regulate tolerance to antibiotics...
  79. pmc Impact of siderophore production by Pseudomonas syringae pv. syringae 22d/93 on epiphytic fitness and biocontrol activity against Pseudomonas syringae pv. glycinea 1a/96
    Annette Wensing
    School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    Appl Environ Microbiol 76:2704-11. 2010
    ..In this work we demonstrated that P. syringae pv. syringae 22d/93 produced a significantly larger amount of siderophores than the pathogen P. syringae pv. glycinea produced. While P. syringae pv. syringae 22d/93 and P. syringae pv...
  80. doi Collision-induced dissociation of three groups of hydroxamate siderophores: ferrioxamines, ferrichromes and coprogens/fusigens
    Edward Mawji
    School of Ocean and Earth Science, National Oceanography Centre, University of Southampton, Southampton SO14 3ZH, UK
    Rapid Commun Mass Spectrom 22:2195-202. 2008
    The behaviour of a series of hydroxamate siderophores--microbially produced iron complexes - was investigated using electrospray ionisation mass spectrometry (ESI-MS)...
  81. ncbi Iron uptake mechanisms and their regulation in pathogenic bacteria
    V Braun
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
    Int J Med Microbiol 291:67-79. 2001
    ..The few principal mechanisms that underly the large variety of iron supply systems will be presented, as well as cases, in which defined iron supply systems are related to virulence...
  82. pmc Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex
    Guanhu Bao
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Chem Biol 6:602-9. 2010
    ..gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth...
  83. pmc A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production
    Laxminarayana R Devireddy
    Case Comprehensive Cancer Center and Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 141:1006-17. 2010
    ..Siderophore-depleted mammalian cells and zebrafish embryos fail to synthesize heme, an iron-dependent mitochondrial process. Our results reveal features of intracellular iron homeostasis that are conserved from bacteria through humans...
  84. ncbi Identification and analysis of a siderophore biosynthetic gene cluster from Agrobacterium tumefaciens C58
    Michelle R Rondon
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiology 150:3857-66. 2004
    ..tumefaciens C58 will have a unique chemical structure. Production of the siderophore was not required for virulence of A. tumefaciens when tested with a standard stem inoculation assay...
  85. pmc Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca
    Eric J Dimise
    Department of Chemistry, Boston College, Eugene F Merkert Chemistry Center, Chestnut Hill, MA 02467, USA
    Proc Natl Acad Sci U S A 105:15311-6. 2008
    ..adenylation domain specificity supports the assignment of this gene cluster as the producer of the fuscachelin siderophores. The proposed nonribosomal peptide biosynthetic pathway exhibits several atypical features, including a ..
  86. pmc Intracellular siderophores are essential for ascomycete sexual development in heterothallic Cochliobolus heterostrophus and homothallic Gibberella zeae
    Shinichi Oide
    Department of Plant Pathology and Plant Microbe Biology, 334 Plant Science Bldg, Cornell University, Ithaca, NY 14853, USA
    Eukaryot Cell 6:1339-53. 2007
    ..Overall, these data demonstrate that iron and intracellular siderophores are essential for successful sexual development of the heterothallic ascomycete C...
  87. ncbi Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T
    Kazutoshi Mihara
    Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Microbiology 150:2587-97. 2004
    ..Primer extension and RT-PCR analyses suggested that the Ab cluster, which includes 18 genes, is organized in seven transcriptional units originating from respective Fur-regulated promoter-operator regions...
  88. ncbi Bacterial iron sources: from siderophores to hemophores
    Cécile Wandersman
    Unité des Membranes Bactériennes, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 75724 Paris Cedex 15, France
    Annu Rev Microbiol 58:611-47. 2004
    ..The second mechanism relies on molecules (siderophores and hemophores) synthesized and released by bacteria into the extracellular medium; these molecules scavenge ..
  89. doi Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A
    Jennifer L Cotton
    Department of Infectious Diseases, Novartis Institutes for BioMedical Research, 500 Technology Square, Cambridge, Massachusetts 02139, USA
    Biochemistry 48:1025-35. 2009
    b>Siderophores are key virulence factors that allow bacteria to grow in iron-restricted environments...
  90. ncbi 24p3 and its receptor: dawn of a new iron age?
    Des R Richardson
    Children s Cancer Institute Australia for Medical Research, Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031, Australia
    Cell 123:1175-7. 2005
    ..Recently, 24p3 has been shown to bind to iron-containing bacterial siderophores. In this issue of Cell, a receptor that internalizes 24p3 is identified...
  91. pmc Siderophores from neighboring organisms promote the growth of uncultured bacteria
    Anthony D'Onofrio
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, Boston, MA 02115, USA
    Chem Biol 17:254-64. 2010
    ..The growth factors produced by one cultured helper strain were identified as new acyl-desferrioxamine siderophores. A panel of previously uncultured isolates exhibited a range of siderophore promiscuity for growth promotion...
  92. doi Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus
    Federico C Beasley
    Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada N6A 5C1
    Mol Microbiol 72:947-63. 2009
    Iron is critical for virtually all forms of life. The production of high-affinity iron chelators, siderophores, and the subsequent uptake of iron-siderophore complexes are a common strategy employed by microorganisms to acquire iron...
  93. pmc The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
    J J De Voss
    Department of Chemistry, University of Queensland, Brisbane, Queensland, Australia 4067
    Proc Natl Acad Sci U S A 97:1252-7. 2000
    ..Analysis of siderophore production by this organism revealed that the biosynthesis of all salicylate-derived siderophores was interrupted...
  94. pmc Acquisition, transport, and storage of iron by pathogenic fungi
    D H Howard
    Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095 1747, USA
    Clin Microbiol Rev 12:394-404. 1999
    ..Under conditions of iron starvation, many fungi synthesize iron chelators known as siderophores. Two classes of compounds that function in iron gathering are commonly observed: hydroxamates and ..
  95. pmc Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4
    Moriah Sandy
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106 9510, USA
    J Nat Prod 73:1038-43. 2010
    ..trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4)...
  96. ncbi Temperature and pyoverdine-mediated iron acquisition control surface motility of Pseudomonas putida
    Miguel A Matilla
    Department of Environmental Protection, Estacion Experimental del Zaidin, CSIC, Profesor Albareda, 1 Granada 18008, Spain
    Environ Microbiol 9:1842-50. 2007
    ..putida. This study constitutes the first report assigning an important role to pyoverdine iron acquisition in en masse bacterial surface movement...
  97. pmc Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
    ....
  98. doi Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice
    Amanda Fortes Francisco
    Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Rua Costa Sena, 171, Campus Universitário Morro do Cruzeiro Cep 35 400 000 Ouro Preto, MG, Brazil
    Exp Parasitol 120:314-9. 2008
    ..The results demonstrate that modification in iron stores increases BZ efficacy...
  99. ncbi Synthesis, structure, and molecular dynamics of gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin
    Evgeny A Fadeev
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 126:12065-75. 2004
    A new general synthesis of the citrate-based siderophores acinetoferrin (Af) and schizokinen (Sz) and their analogues is described...
  100. ncbi Siderophore production by Fusarium venenatum A3/5
    M G Wiebe
    Sohngaardsholmsvej 49, Institute of Life Sciences, Aalborg University, DK 9000 Aalborg, Denmark
    Biochem Soc Trans 30:696-8. 2002
    ..03 h(-1). Siderophore production was greatest at pH 4.7 and was significantly reduced at pHs above 6.0. Siderophore production could be enhanced by providing insoluble iron instead of soluble iron in continuous flow cultures...
  101. ncbi Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis
    Marcus Miethke
    Philipps Universitat Marburg, Fachbereich Chemie Biochemie, Marburg, Germany
    FEBS J 273:409-19. 2006
    Aryl acid adenylation domains are the initial enzymes for aryl-capping of catecholic siderophores in a plethora of microorganisms...

Research Grants88

  1. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2004
    ..previous grant period the Principal Investigator discovered a new class of self-assembling amphiphilic peptide siderophores, the marinobactins and aquachelins, produced by two phylogenetically distinct genera within the marine gamma ..
  2. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2007
    ..and also expresses activities required for utilization of host heme compounds as well as certain non-native siderophores, including the potent siderophore enterobactin...
  3. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  4. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..RELEVANCE: Current iron chelation therapy such as deferoxamine (DFO) relies on chelators inspired by bacterial siderophores intended to retrieve biologically available iron...
  5. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..In this research, we will define the role of key Fbp system components in Bordetella utilization of ferric siderophores and characterize an apparently novel mechanism for utilization of ferrous iron...
  6. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  7. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  8. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
    ..The mycobactins have been proposed as novel targets for TB drugs since these small-molecule iron-chelators (siderophores) produced by Mycobacterium tuberculosis (MTb) are responsible for obtaining iron from the human host, a process ..
  9. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    LAXMINARAYANA DEVIREDDY; Fiscal Year: 2009
    ..Iron in this pool is hypothesized to associate with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3...
  10. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2010
    ..Iron in this pool is hypothesized to associate with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3...
  11. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2003
    ..One such system involved in siderophore-mediated iron uptake, is the focus of this application. Siderophores are high-affinity iron chelators secreted from the bacterial cell to scavenge iron from host iron-binding ..
  12. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..One such system involved in siderophore-mediated iron uptake, is the focus of this application. Siderophores are high-affinity iron chelators secreted from the bacterial cell to scavenge iron from host iron-binding ..
  13. SIDEROPHORES, ANALOGS & BIOCONJUGATES: SYNTHESIS & STUDY
    Marvin Miller; Fiscal Year: 1991
    ..The focus will be on the syntheses and studies of microbial iron chelators (siderophores), analogs and conjugates with antimicrobial agents...
  14. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    Aravamudan S Gopalan; Fiscal Year: 2010
    ..that the iron complexation abilities (advantages and disadvantages) of mixed ligand systems present in several siderophores has not been widely studied...
  15. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    ARAVAMUDAN GOPALAN; Fiscal Year: 2009
    ..that the iron complexation abilities (advantages and disadvantages) of mixed ligand systems present in several siderophores has not been widely studied...
  16. Chelators for Iron(III) for Therapeutic Uses and Probing Cellular Iron Transport
    ARAVAMUDAN GOPALAN; Fiscal Year: 2009
    ..that the iron complexation abilities (advantages and disadvantages) of mixed ligand systems present in several siderophores has not been widely studied...
  17. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2003
    ..previous grant period the Principal Investigator discovered a new class of self-assembling amphiphilic peptide siderophores, the marinobactins and aquachelins, produced by two phylogenetically distinct genera within the marine gamma ..
  18. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2002
    ..previous grant period the Principal Investigator discovered a new class of self-assembling amphiphilic peptide siderophores, the marinobactins and aquachelins, produced by two phylogenetically distinct genera within the marine gamma ..
  19. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2001
    ..previous grant period the Principal Investigator discovered a new class of self-assembling amphiphilic peptide siderophores, the marinobactins and aquachelins, produced by two phylogenetically distinct genera within the marine gamma ..
  20. STRUCTURES OF SIDEROPHORE MEMBRANE TRANSPORT PROTEINS
    Dick van der Helm; Fiscal Year: 2000
    Many aerobic microorganisms produce siderophores which are secreted into the environment. The siderophores chelate Fe3+ specifically. The complexation constants are very high (10\22-10/50). The complexes are too large (M.W...
  21. CONTROL OF BACTERIAL TOXINS BY VIRUSES AND PLASMIDS
    Randall K Holmes; Fiscal Year: 2010
    ..diphtheriae to use other siderophores (e.g., desferrioxamine, ferrichrome, rhizoferrin and the recently discovered siderophores from C...
  22. STRUCTURES OF SIDEROPHORE MEMBRANE TRANSPORT PROTEINS
    Dick van der Helm; Fiscal Year: 1999
    Many aerobic microorganisms produce siderophores which are secreted into the environment. The siderophores chelate Fe3+ specifically. The complexation constants are very high (10\22-10/50). The complexes are too large (M.W...
  23. RECEPTOR MEDIATED UPTAKE OF IRON COMPLEXES IN BACTERIA
    MARK MCINTOSH; Fiscal Year: 1999
    ..the molecular processes by which Escherichia coli and related organisms actively transport iron complexed to siderophores or iron-binding proteins to satisfy their nutritional iron requirements...
  24. Iron acquistion in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2003
    ..and also expresses activities required for the utilization of host heme compounds as well as certain non-native siderophores, including the potent and ubiquitous catechol siderophore enterobactin...
  25. Role of Lipocalin 2 in host defense against Klebsiella pneumoniae infection
    Yvonne Chan; Fiscal Year: 2009
    ..Lipocalin 2 acts as a receptor for siderophores - bacterial-derived proteins that scavenge miniscule amounts of free iron needed for bacterial metabolism...
  26. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2006
    ..and also expresses activities required for utilization of host heme compounds as well as certain non-native siderophores, including the potent siderophore enterobactin...
  27. Role of Lipocalin 2 in host defense against Klebsiella pneumoniae infection
    Yvonne R Chan; Fiscal Year: 2010
    ..Lipocalin 2 acts as a receptor for siderophores - bacterial-derived proteins that scavenge miniscule amounts of free iron needed for bacterial metabolism...
  28. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2004
    ..and also expresses activities required for utilization of host heme compounds as well as certain non-native siderophores, including the potent siderophore enterobactin...
  29. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2005
    ..and also expresses activities required for utilization of host heme compounds as well as certain non-native siderophores, including the potent siderophore enterobactin...
  30. Role of Lipocalin 2 in host defense against Klebsiella pneumoniae infection
    Yvonne Chan; Fiscal Year: 2007
    ..Lipocalin 2 acts as a receptor for siderophores - bacterial-derived proteins that scavenge miniscule amounts of free iron needed for bacterial metabolism...
  31. HEMIN UTILIZATION BY P GINGIVALIS
    Caroline Genco; Fiscal Year: 1999
    ..The mechanisms involved in iron acquisition will be examined by 1) determining if B. gingivalis can utilize siderophores produced by other organisms, 2) if B. gingivalis does indeed produce its own siderophores, and 3) if B...
  32. IRON UTILIZATION BY BACTEROIDES GINGIVALIS
    Caroline Genco; Fiscal Year: 1991
    ..The mechanisms involved in iron acquisition will be examined by 1) determining if B. gingivalis can utilize siderophores produced by other organisms, 2) if B. gingivalis does indeed produce its own siderophores, and 3) if B...
  33. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1993
    ..by iron requirement and unavailability, microorganisms secrete high-affinity iron-binding compounds called siderophores with several types of chemical structures found among the more than 100 compounds characterized to data...
  34. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1991
    ..by iron requirement and unavailability, microorganisms secrete high-affinity iron-binding compounds called siderophores with several types of chemical structures found among the more than 100 compounds characterized to data...
  35. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1992
    ..by iron requirement and unavailability, microorganisms secrete high-affinity iron-binding compounds called siderophores with several types of chemical structures found among the more than 100 compounds characterized to data...
  36. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2009
    ..provided by applicant): The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  37. Assembly Line Biosynthesis of Bacterial Siderophores
    Jorge H Crosa; Fiscal Year: 2010
    ..provided by applicant): The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  38. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2009
    ..provided by applicant): The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  39. DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 1993
    ..and that conjugates of antifungal agents with species specific or selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents directly into the cells of pathogenic organisms...
  40. BIOLOGICAL EVALUATION OF NEW ACTINIDE-CHELATING AGENTS
    Patricia Durbin; Fiscal Year: 1993
    ..that macromolecules composed of bidentate Fe(III)-binding groups of microbial iron-sequestering agents (siderophores) would complex Pu(IV) at pH 7 and spare essential divalent metals...
  41. HAEMOPHILUS INFLUENZAE PATHOGENESIS--ACQUISTION OF IRON
    Terrence Stull; Fiscal Year: 1990
    ..influenzae type b. The presence of low molecular weight iron-binding compounds called siderophores will be investigated by biochemical assays for phenolates and hydroxamates and bioassays using mutants to ..
  42. Therapies of infections caused by gram-positive bacteria
    Dominique Missiakas; Fiscal Year: 2009
    ..3 proposal addresses the need for new antibiotics by unraveling molecular mechanisms that lead to assembly of siderophores, proteins, capsules or teichoic acids in the cell wall envelope of B. anthracis and S. aureus...
  43. ENERGY TRANSDUCTION BETWEEN MEMBRANES
    Kathleen Postle; Fiscal Year: 2009
    ..To acquire large, scarce, important nutrients such as iron-siderophores and vitamin B12, active transporters with sub-nanomolar affinities for their transport substrates are located ..
  44. ENERGY TRANSDUCTION BETWEEN MEMBRANES
    Kathleen Postle; Fiscal Year: 2010
    ..To acquire large, scarce, important nutrients such as iron-siderophores and vitamin B12, active transporters with sub-nanomolar affinities for their transport substrates are located ..
  45. Iron transport and its role in pathogenesis of Vibrio cholerae
    SHELLEY PAYNE; Fiscal Year: 2009
    ..These iron transport systems include the endogenous siderophore vibriobactin, receptors for exogenous siderophores and for heme, and ferric and ferrous iron uptake systems...
  46. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2005
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  47. IRON METABOLISM OF MICROORGANISMS
    JOHN NEILANDS; Fiscal Year: 1980
    ..Both components of the iron uptake pathway comprising the high affinity system, namely, siderophores and their membrane receptors, will be investigated...
  48. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2009
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  49. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2007
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  50. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2006
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  51. DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 2000
    ..agents), and that conjugates of antifungal agents with species selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents into cells of pathogenic organisms or that selective ..
  52. DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFESTIONS
    Marvin Miller; Fiscal Year: 1992
    ..and that conjugates of antifungal agents with species specific or selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents directly into the cells of pathogenic organisms...
  53. DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFESTIONS
    Marvin Miller; Fiscal Year: 1991
    ..and that conjugates of antifungal agents with species specific or selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents directly into the cells of pathogenic organisms...
  54. DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 2001
    ..agents), and that conjugates of antifungal agents with species selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents into cells of pathogenic organisms or that selective ..
  55. DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 1999
    ..agents), and that conjugates of antifungal agents with species selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents into cells of pathogenic organisms or that selective ..
  56. MOLECULAR ANALYSIS OF YERSINIABACTIN BIOSYNTHESIS
    Christopher Walsh; Fiscal Year: 2001
    Iron chelating siderophores and several peptide antibiotics are assembled by nonribosomal peptide synthase complexes via a thioltemplate mechanism...
  57. MOLECULAR ANALYSIS OF YERSINIABACTIN BIOSYNTHESIS
    Christopher Walsh; Fiscal Year: 1999
    Iron chelating siderophores and several peptide antibiotics are assembled by nonribosomal peptide synthase complexes via a thioltemplate mechanism...
  58. MOLECULAR ANALYSIS OF YERSINIABACTIN BIOSYNTHESIS
    Christopher Walsh; Fiscal Year: 2000
    Iron chelating siderophores and several peptide antibiotics are assembled by nonribosomal peptide synthase complexes via a thioltemplate mechanism...
  59. BIOLOGICAL EVALUATION OF NEW ACTINIDE CHELATING AGENTS
    Patricia Durbin; Fiscal Year: 1999
    ..that synthetic ligands containing the bidentate Fe(III)-binding groups of microbial iron-sequestering agents (siderophores) would stably complex Pu at Ph 7 and spare essential divalent metals...
  60. Virulence-conferring siderophore biosynthesis inhibitors
    LUIS QUADRI; Fiscal Year: 2005
    ..Many lines of evidence indicate that iron acquisition systems based on iron-chelators, referred to as siderophores, are required for the virulence of these pathogens...
  61. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..Erythrocytes, bacteria and bacterial siderophores, and ferritin-loaded liposomes (used as models of eukaryotic cells) will be used...
  62. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1990
    ..Erythrocytes, bacteria and bacterial siderophores, and ferritin-loaded liposomes (used as models of eukaryotic cells) will be used...
  63. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2004
    ..the applicant): The goal of this research is to understand the mechanism of biosynthesis of bacterial peptide siderophores. We use as a paradigm the peptide siderophore anguibactin that is produced by the pathogenic bacterium Vibrio ..
  64. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2002
    ..the applicant): The goal of this research is to understand the mechanism of biosynthesis of bacterial peptide siderophores. We use as a paradigm the peptide siderophore anguibactin that is produced by the pathogenic bacterium Vibrio ..
  65. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2005
    ..the applicant): The goal of this research is to understand the mechanism of biosynthesis of bacterial peptide siderophores. We use as a paradigm the peptide siderophore anguibactin that is produced by the pathogenic bacterium Vibrio ..
  66. Investigations of the Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2009
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  67. Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2006
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  68. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2003
    ..the applicant): The goal of this research is to understand the mechanism of biosynthesis of bacterial peptide siderophores. We use as a paradigm the peptide siderophore anguibactin that is produced by the pathogenic bacterium Vibrio ..
  69. Investigations of the Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2007
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  70. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA ARMSTRONG; Fiscal Year: 2000
    ..can accumulate iron supplied by their native macrocyclic dihydroxamate siderophore, alcaligin, as well as siderophores produced by other microbial species...
  71. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA ARMSTRONG; Fiscal Year: 2001
    ..can accumulate iron supplied by their native macrocyclic dihydroxamate siderophore, alcaligin, as well as siderophores produced by other microbial species...
  72. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 1999
    ..This grant renewal will define more precisely the nature of these pathways. Upon demonstration that the siderophores are expressed within infected host cells, a set of mutants will be used to ascertain the role of the iron ..
  73. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA ARMSTRONG; Fiscal Year: 1999
    ..can accumulate iron supplied by their native macrocyclic dihydroxamate siderophore, alcaligin, as well as siderophores produced by other microbial species...
  74. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2010
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  75. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2010
    ..for all living species, and the TB community thought that Mtb acquired its iron in vivo solely via its iron siderophores;thus our identification of a novel heme acquisition pathway whereby iron is obtained via the uptake of human ..
  76. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2007
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  77. BIOSYNTHESIS AND REGULATION OF AROMATICS IN PSEUDOMONAS
    Roy Jensen; Fiscal Year: 1990
    ..pathway as a source of the latter essential metabolites as well as for pyocyanine pigment and iron-binding siderophores. Thus, an ideal basis exists for manipulation of the host-pathogen relationship since a multiplicity of enzyme ..
  78. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2009
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  79. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2009
    ..for all living species, and the TB community thought that Mtb acquired its iron in vivo solely via its iron siderophores;thus our identification of a novel heme acquisition pathway whereby iron is obtained via the uptake of human ..
  80. Core--Protein Characterization
    ELIZABETH KOMIVES; Fiscal Year: 2005
    ..With Dr. Tebo, the investigators will study pyoverdins (siderophores) and their metal complexes...