siderophores

Summary

Summary: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Top Publications

  1. pmc Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
  2. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
  3. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
  4. pmc Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
  5. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
  6. ncbi New roles for bacterial siderophores in metal transport and tolerance
    Isabelle J Schalk
    UMR7242, University of Strasbourg CNRS, ESBS, Blvd Sebastien Brant, F 67413 Illkirch, Strasbourg, France
    Environ Microbiol 13:2844-54. 2011
  7. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
  8. pmc Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B 16, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Eukaryot Cell 7:20-7. 2008
  9. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
  10. ncbi Chemistry and biology of siderophores
    Robert C Hider
    Division of Pharmaceutical Science, King s College, London, SE1 9NH, UK
    Nat Prod Rep 27:637-57. 2010

Detail Information

Publications348 found, 100 shown here

  1. pmc Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
    ..Due to the key role of many siderophores during virulence, coevolution led to sophisticated strategies of siderophore neutralization by mammals and (re)..
  2. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
    ..In many cases, this involves the secretion and internalisation of extracellular ferric chelators called siderophores. Ferrous iron can also be directly imported by the G protein-like transporter, FeoB...
  3. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..Some invading bacteria respond by producing specific iron chelators-siderophores-that remove the iron from the host sources...
  4. pmc Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
    ....
  5. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
    ..Here we report that NGAL tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent ..
  6. ncbi New roles for bacterial siderophores in metal transport and tolerance
    Isabelle J Schalk
    UMR7242, University of Strasbourg CNRS, ESBS, Blvd Sebastien Brant, F 67413 Illkirch, Strasbourg, France
    Environ Microbiol 13:2844-54. 2011
    b>Siderophores are chelators with extremely strong affinity for ferric iron and are best known for their capacity to feed microorganisms with this metal...
  7. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
    ..we discuss the most recent findings on the mechanisms involved in maintaining iron homeostasis with a focus on siderophores, low-molecular-mass iron chelators, employed for iron uptake and storage...
  8. pmc Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B 16, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Eukaryot Cell 7:20-7. 2008
  9. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
    ..By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, ..
  10. ncbi Chemistry and biology of siderophores
    Robert C Hider
    Division of Pharmaceutical Science, King s College, London, SE1 9NH, UK
    Nat Prod Rep 27:637-57. 2010
    b>Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment...
  11. pmc Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
    ..membrane transporter system, fbpABC, that is required for the utilization of multiple structurally distinct siderophores including alcaligin, enterobactin, ferrichrome, and desferrioxamine B...
  12. pmc HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
    ..Overall, these results indicated that C. neoformans employs multiple strategies for iron acquisition during infection...
  13. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
    ..Pathways positively affected by HapX include production of the ribotoxin AspF1 and siderophores, which are known virulence determinants...
  14. ncbi Molecular mechanisms of iron uptake in fungi
    Daniel J Kosman
    Department of Biochemistry, 140 Farber Hall, The University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Mol Microbiol 47:1185-97. 2003
    ..The integration of these multiple uptake mechanisms and their regulation into over-all iron homeostasis in yeast concludes this brief review...
  15. pmc Mammalian siderophores, siderophore-binding lipocalins, and the labile iron pool
    Colin Correnti
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 287:13524-31. 2012
    Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from the environment and from the host during infection; animals use proteins such as transferrin and ferritin to transport and store iron...
  16. pmc Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron
    Peter Hortschansky
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
    EMBO J 26:3157-68. 2007
    ..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
  17. ncbi The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC)
    Martin Eisendle
    Department of Molecular Biology, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 49:359-75. 2003
    The filamentous ascomycete A. nidulans produces two major siderophores: it excretes triacetylfusarinine C to capture iron and contains ferricrocin intracellularly...
  18. ncbi Structural biology of bacterial iron uptake
    Karla D Krewulak
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochim Biophys Acta 1778:1781-804. 2008
    ..include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron chelators termed siderophores. The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which ..
  19. ncbi Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii
    Daniel L Zimbler
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Biometals 22:23-32. 2009
    ..Unexpectedly, the ability of this pathogen to acquire iron depends on the expression of a SecA protein secretion function, which has not been associated with iron acquisition in bacteria...
  20. pmc Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis
    Kathryn E Bushley
    Department of Plant Pathology and Plant Microbe Biology, 334 Plant Science Building, Cornell University, Ithaca, NY 14853, USA
    BMC Evol Biol 8:328. 2008
    Most filamentous ascomycete fungi produce high affinity iron chelators called siderophores, biosynthesized nonribosomally by multimodular adenylating enzymes called nonribosomal peptide synthetases (NRPSs)...
  21. ncbi Iron uptake and metabolism in pseudomonads
    Pierre Cornelis
    Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium
    Appl Microbiol Biotechnol 86:1637-45. 2010
    ..Like for other bacteria, iron is a key nutrient for pseudomonads. The fluorescent pseudomonads produce siderophores, the best known being the fluorescent high-affinity peptidic pyoverdines...
  22. pmc Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa
    Iain L Lamont
    Department of Biochemistry and Centre for Gene Research, University of Otago, P O Box 56, Dunedin, New Zealand
    Proc Natl Acad Sci U S A 99:7072-7. 2002
    Numerous bacteria secrete low molecular weight compounds termed siderophores that have a high affinity for iron ions...
  23. pmc Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species
    Gregory L Challis
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom
    Proc Natl Acad Sci U S A 100:14555-61. 2003
    ..is illustrated with examples of the coproduction of synergistically acting antibiotics and contingently acting siderophores: two well-known classes of secondary metabolite...
  24. pmc The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion
    Petra Heymann
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Infect Immun 70:5246-55. 2002
    ..albicans by constructing sit1 deletion strains and testing their virulence and ability to utilize a range of siderophores and other iron complexes...
  25. ncbi Cooperation and competition in pathogenic bacteria
    Ashleigh S Griffin
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Nature 430:1024-7. 2004
    ..The cooperative trait that we examine is the production of siderophores, iron-scavenging agents, in the pathogenic bacterium Pseudomonas aeruginosa...
  26. pmc In vitro and in vivo evaluation of selected 68Ga-siderophores for infection imaging
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nucl Med Biol 39:361-9. 2012
    b>Siderophores are low-molecular-mass iron chelators serving as iron transporters for almost all bacteria, fungi and some plants...
  27. pmc Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus
    Anja Wallner
    Biocenter, Medical University of Innsbruck, Austria
    Appl Environ Microbiol 75:4194-6. 2009
    ..Thus, ferricrocin represents the first intracellular iron transporter identified in any organism...
  28. pmc The phytopathogen Pseudomonas syringae pv. tomato DC3000 has three high-affinity iron-scavenging systems functional under iron limitation conditions but dispensable for pathogenesis
    Alexander M Jones
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    J Bacteriol 193:2767-75. 2011
    High-affinity iron scavenging through the use of siderophores is a well-established virulence determinant in mammalian pathogenesis. However, few examples have been reported for plant pathogens...
  29. ncbi Secretion, but not overall synthesis, of catecholate siderophores contributes to virulence of extraintestinal pathogenic Escherichia coli
    Mélissa Caza
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Mol Microbiol 80:266-82. 2011
    Extraintestinal pathogenic Escherichia coli (ExPEC) use siderophores to sequester iron during infection. Enterobactin and salmochelins are catecholate siderophores produced by some ExPEC strains and other pathogenic enterobacteria...
  30. ncbi Iron and fungal pathogenesis: a case study with Cryptococcus neoformans
    Won Hee Jung
    The Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Cell Microbiol 10:277-84. 2008
    ..neoformans is in host tissue. Achieving these goals may contribute to an understanding of the notable predilection of the fungus for the mammalian central nervous system...
  31. pmc The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 12:1035-41. 2010
    ..To ensure an adequate supply with iron, Aspergillus fumigatus employs extra- and intracellular siderophores (low-molecular mass iron chelators), which are of importance for fungal growth in particular during iron ..
  32. pmc The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence
    Anna H T Hissen
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Infect Immun 73:5493-503. 2005
    ..We have previously shown that survival of A. fumigatus in serum may be related to secretion of siderophores. In this study, we identified and characterized the sidA gene of A...
  33. pmc The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
    J J De Voss
    Department of Chemistry, University of Queensland, Brisbane, Queensland, Australia 4067
    Proc Natl Acad Sci U S A 97:1252-7. 2000
    ..Analysis of siderophore production by this organism revealed that the biosynthesis of all salicylate-derived siderophores was interrupted...
  34. pmc Role of the Fur regulon in iron transport in Bacillus subtilis
    Juliane Ollinger
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 188:3664-73. 2006
    ..the intact bacillibactin siderophore is restored (by the introduction of a functional sfp gene) or exogenous siderophores are provided...
  35. pmc The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans
    Martin Eisendle
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Eukaryot Cell 5:1596-603. 2006
    ....
  36. pmc Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization
    Lena H Hwang
    Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 4:e1000044. 2008
    ..H. capsulatum acquires iron through the action of ferric reductases and the production of siderophores, but the genes responsible for these activities and their role in virulence have not been determined...
  37. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..Furthermore, A. fumigatus utilizes two intracellular siderophores, ferricrocin and hydroxyferricrocin, to store iron...
  38. ncbi SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans
    H Oberegger
    Department of Microbiology, Medical School, University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria
    Mol Microbiol 41:1077-89. 2001
    Under conditions of low iron availability, most fungi excrete siderophores in order to mobilize extracellular iron...
  39. pmc Loihichelins A-F, a suite of amphiphilic siderophores produced by the marine bacterium Halomonas LOB-5
    Vanessa V Homann
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    J Nat Prod 72:884-8. 2009
    A suite of amphiphilic siderophores, loihichelins A-F, were isolated from cultures of the marine bacterium Halomonas sp. LOB-5...
  40. pmc An extracytoplasmic function sigma factor-mediated cell surface signaling system in Pseudomonas syringae pv. tomato DC3000 regulates gene expression in response to heterologous siderophores
    Eric Markel
    United States Department of Agriculture Agricultural Research Service, Ithaca, New York 14853, USA
    J Bacteriol 193:5775-83. 2011
    ..syringae pyoverdine cluster. Additionally, we identified siderophores that induce the activity of PSPTO_1203 and used this information to investigate the functional components of ..
  41. ncbi Pyoverdines: pigments, siderophores and potential taxonomic markers of fluorescent Pseudomonas species
    J M Meyer
    Laboratoire de Microbiologie et Génétique, UPRES A 7010, Universite Louis Pasteur, Strasbourg, France
    Arch Microbiol 174:135-42. 2000
    ..A promising future is expected from recent developments which indicate that pyoverdines might be considered as potent and easy-to-handle taxonomic markers for the fluorescent species of the genus Pseudomonas...
  42. pmc Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus
    Sabiha Yasmin
    Division of Molecular Biology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 109:E497-504. 2012
    ..Concordant with bilateral demand for mevalonate, iron starvation decreased the ergosterol content and composition, a phenotype that is mitigated in TAFC-lacking mutants...
  43. ncbi Chemical aspects of siderophore mediated iron transport
    Hakim Boukhalfa
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Biometals 15:325-39. 2002
    ..Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells...
  44. ncbi Recent insights into iron import by bacteria
    Volkmar Braun
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Curr Opin Chem Biol 15:328-34. 2011
    ..The bacteria cope with the iron deficiency by using host heme or siderophores synthesized by themselves or other microbes...
  45. ncbi Pseudomonas siderophores in the sputum of patients with cystic fibrosis
    Lois W Martin
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biometals 24:1059-67. 2011
    ..P. aeruginosa can acquire this element by secreting pyoverdine and pyochelin, iron-chelating compounds (siderophores) that scavenge iron and deliver it to the bacteria...
  46. ncbi Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes
    B M Rowland
    Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, NY 12208, USA
    Gene 178:119-23. 1996
    ..DhbC is also 35% identical to the Bs menaquinone-specific isochorismate synthase, MenF, illustrating an example of gene duplication. Operon disruption studies suggested that the dhb genes comprise an operon of at least four genes...
  47. pmc Characterization of an iroBCDEN gene cluster on a transmissible plasmid of uropathogenic Escherichia coli: evidence for horizontal transfer of a chromosomal virulence factor
    Liisa Johanna Sorsa
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany
    Infect Immun 71:3285-93. 2003
    ..fepA cir fiu aroB mutant, IroN, but not IroBCDE, mediated the utilization of structurally related catecholate siderophores, including 2,3-dihydroxybenzoyl-L-serine, 2,3-dihydroxybenzoyl-D-ornithine, 2,3-dihydroxybenzoic acid, and ..
  48. pmc Role of porins in iron uptake by Mycobacterium smegmatis
    Christopher M Jones
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, Alabama 35294, USA
    J Bacteriol 192:6411-7. 2010
    Many bacteria rely on siderophores to extract iron from the environment. However, acquisition of iron-loaded siderophores is dependent on high-affinity uptake systems that are not produced under high-iron conditions...
  49. ncbi Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungi
    Torsten Schwecke
    Institute of Chemistry, Technical University Berlin, Franklinstrasse 29, 10587 Berlin, Germany
    Chembiochem 7:612-22. 2006
    ..A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains...
  50. pmc Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 39:1175-83. 2012
    ..We have shown that siderophores can be labelled with (68)Ga and can be used for PET imaging of A. fumigatus infection in rats...
  51. pmc The tomato rhizosphere, an environment rich in nitrogen-fixing Burkholderia species with capabilities of interest for agriculture and bioremediation
    Jesus Caballero-Mellado
    Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Ap Postal 565 A, Cuernavaca, Morelos, Mexico
    Appl Environ Microbiol 73:5308-19. 2007
    ..Most of the diazotrophic Burkholderia species produced hydroxamate-type siderophores. Certainly, the N2-fixing Burkholderia species associated with plants have great potential for agro-..
  52. ncbi Siderophores of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis
    Melissa K Wilson
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Biochem Biophys Res Commun 348:320-5. 2006
    ..anthracis Sterne strains (USAMRIID, 7702, and 34F2) and Bacillus cereus ATCC 14579 excrete two catecholate siderophores, petrobactin (which contains 3,4-dihydroxybenzoyl moieties) and bacillibactin (which contains 2,3-..
  53. pmc Environmental factors modulating antibiotic and siderophore biosynthesis by Pseudomonas fluorescens biocontrol strains
    B K Duffy
    Phytopathology Group, Institute of Plant Sciences, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Appl Environ Microbiol 65:2429-38. 1999
    ..the production of the antibiotics 2,4-diacetylphloroglucinol (PHL), pyoluteorin (PLT), and pyrrolnitrin and the siderophores salicylic acid and pyochelin by the model strain CHA0, which was isolated from a natural disease-suppressive ..
  54. ncbi Siderophore production by the marine-derived Aureobasidium pullulans and its antimicrobial activity
    W L Wang
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, Shandong 266003, China
    Bioresour Technol 100:2639-41. 2009
    ..1mg/ml of the siderophore. The crude siderophore produced by the yeast strain HN6.2 was able to inhibit cell growth of Vibrio anguillarum and Vibrio parahaemolyticus, isolated from the diseased marine animals...
  55. pmc Catecholate siderophores protect bacteria from pyochelin toxicity
    Conrado Adler
    Departamento de Bioquimica de la Nutricion, INSIBIO Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional de Tucumán San Miguel de Tucumán, Tucuman, Argentina
    PLoS ONE 7:e46754. 2012
    Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron from the environment...
  56. pmc SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin
    Michael Blatzer
    Division of Molecular Biology, Biocenter, Fritz Pregl Str 3, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Appl Environ Microbiol 77:4959-66. 2011
    The opportunistic fungal pathogen Aspergillus fumigatus produces four types of siderophores, low-molecular-mass iron chelators: it excretes fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and accumulates ferricrocin (..
  57. ncbi The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis
    Graeme L Card
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Biol Chem 280:13978-86. 2005
    ....
  58. pmc Microbial siderophores exert a subtle role in Arabidopsis during infection by manipulating the immune response and the iron status
    Alia Dellagi
    Laboratoire des Interactions Plantes Pathogènes, UMR 217, INRA AgroParisTech Université Pierre et Marie Curie, 75231 Paris Cedex 05, France
    Plant Physiol 150:1687-96. 2009
    b>Siderophores (ferric ion chelators) are secreted by organisms in response to iron deficiency...
  59. ncbi Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity
    Sandra Matthijs
    Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Building E, Pleinlaan 2, 1050 Brussels, Belgium
    Environ Microbiol 9:425-34. 2007
    Under conditions of iron limitation Pseudomonas fluorescens ATCC 17400 produces two siderophores, pyoverdine, and a second siderophore quinolobactin, which itself results from the hydrolysis of the unstable molecule 8-hydroxy-4-methoxy-2-..
  60. ncbi Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Roma, Italy
    Res Microbiol 162:279-84. 2011
    ..The results demonstrated that all A. baumannii isolates tested share the coding potential for two endogenous siderophores, a heme-acquisition and a ferrous iron-uptake system...
  61. ncbi Siderophore-mediated iron transport in Bacillus subtilis and Corynebacterium glutamicum
    Emily A Dertz
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 1460, USA
    J Biol Inorg Chem 11:1087-97. 2006
    ..Although both are triscatecholamide trilactones, the structural differences of these two siderophores result in opposite metal chiralities, different affinity for ferric ion, and dissimilar iron transport ..
  62. ncbi Iron transport and regulation, cell signalling and genomics: lessons from Escherichia coli and Pseudomonas
    Paolo Visca
    Molecular Microbiology Unit, National Institute for Infectious Diseases, Via Portuense 292, 00149 Rome, Italy
    Mol Microbiol 45:1177-90. 2002
    A variety of bacterial species secrete and take up chelating compounds that enable acquisition of iron (siderophores)...
  63. ncbi The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake
    H Haas
    Department of Microbiologie Medical School, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    J Biol Chem 274:4613-9. 1999
    ..These results demonstrate that SREA plays a central role in iron uptake in addition to siderophore biosynthesis...
  64. pmc Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents
    Marvin J Miller
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Biometals 22:61-75. 2009
    ..and active transport relies on the biosyntheses and use of microbe-selective iron-chelating compounds called siderophores. Our studies, and those of others, demonstrate that siderophores and analogs can be used for iron transport-..
  65. ncbi Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport
    Caleb W Dorsey
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Microbiology 149:1227-38. 2003
    ..pestis phosphopantetheinyl transferase, all of them involved in the assembly and utilization of catechol siderophores in other bacteria, were found next to the dhbACEB locus. This A...
  66. ncbi Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005
    ..transport capabilities for utilizing plant-derived compounds, the apparent ability to use a diversity of iron siderophores, detoxification systems to protect from oxidative stress, and the lack of a type III secretion system and ..
  67. ncbi A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
    Gregory L Challis
    Department of Chemistry, Warwick University, Coventry CV4 7AL, UK
    Chembiochem 6:601-11. 2005
  68. ncbi Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus
    Johnson Cheung
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mol Microbiol 74:594-608. 2009
    b>Siderophores are iron-scavenging molecules produced by many microbes. In general, they are synthesized using either non-ribosomal peptide synthetase (NRPS) or NRPS-independent siderophore (NIS) pathways...
  69. pmc Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores
    A H T Hissen
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Infect Immun 72:1402-8. 2004
    ..fumigatus. In human serum, all of the monoferric transferrin was converted to apoTf within 8 h. Siderophores were secreted by A. fumigatus after 8 h of growth in MEM-serum and 12 h in MEM-holoTf...
  70. pmc Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4
    Moriah Sandy
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106 9510, USA
    J Nat Prod 73:1038-43. 2010
    ..trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4)...
  71. ncbi Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye view
    Byron C Chu
    Biochemistry Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    Biometals 23:601-11. 2010
    b>Siderophores are biosynthetically produced and secreted by many bacteria, yeasts, fungi and plants, to scavenge for ferric iron (Fe(3+))...
  72. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
    Pyoverdines are a group of structurally related siderophores produced by fluorescent Pseudomonas species...
  73. pmc OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints
    Takahiro Aoyama
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Mol Biol 70:681-92. 2009
    ..These results suggest that OsYSL18 is an iron-phytosiderophore transporter involved in the translocation of iron in reproductive organs and phloem in joints...
  74. ncbi Microbial siderophore-mediated transport
    G Winkelmann
    Microbiology and Biotechnology, University of Tuebingen, Auf der Morgenstelle 28, 72076 Tuebingen, Germany
    Biochem Soc Trans 30:691-6. 2002
    Microbial iron chelates, called siderophores, are synthesized by bacteria and fungi in response to low iron availability in the environment...
  75. ncbi Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex
    A Gotschlich
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Germany
    Syst Appl Microbiol 24:1-14. 2001
    ..All strains were also screened for the production of extracellular lipase, chitinase, protease, and siderophores. However, no correlation between the AHL production and the synthesis of these exoproducts was apparent...
  76. ncbi The role of siderophores in iron acquisition by photosynthetic marine microorganisms
    Brian M Hopkinson
    Department of Geosciences, Princeton University, NJ 08544, USA
    Biometals 22:659-69. 2009
    ..Neither group appears to produce siderophores, although some coastal cyanobacteria do...
  77. ncbi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
    ..However, molecular details of how bacteria activate HIF-1 remain unclear. Here, we pursued the role of bacterial siderophores in HIF-1 activation during infection with Enterobacteriaceae.
  78. ncbi Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria
    Michelle A Parent
    Department of Veterinary and Animal Sciences, Paige Laboratory, University of Massachusetts, Amherst, MA 01003, USA
    Microb Pathog 32:239-48. 2002
    b>Siderophores are low molecular weight molecules that allow bacteria to acquire iron from host cell proteins. 2,3-dihydroxybenzoic acid (DHBA) is the only known siderophore produced by the intracellular pathogen Brucella abortus...
  79. pmc Bordetella AlcS transporter functions in alcaligin siderophore export and is central to inducer sensing in positive regulation of alcaligin system gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 187:3650-61. 2005
    ....
  80. ncbi Studies and syntheses of siderophores, microbial iron chelators, and analogs as potential drug delivery agents
    J M Roosenberg
    Department of Chemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Curr Med Chem 7:159-97. 2000
    b>Siderophores (microbial iron chelators) play an extremely important role in microbial pathogenicity...
  81. ncbi The siderophore-mediated iron acquisition systems of Acinetobacter baumannii ATCC 19606 and Vibrio anguillarum 775 are structurally and functionally related
    Caleb W Dorsey
    Department of Microbiology, 40 Pearson Hall, Miami University, Oxford, OH 45056, USA
    Microbiology 150:3657-67. 2004
    ..similarities, as well as the structural similarity of anguibactin and acinetobactin, suggested that these two siderophores could be utilized by both bacterial strains, a possibility that was confirmed by siderophore utilization ..
  82. pmc Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne
    Albert Koulman
    Lipid Profiling and Signaling Group, MRC HNR, Elsie Widdowson Laboratory, Cambridge, UK
    Phytochemistry 75:128-39. 2012
    ..Epichloënin A is unusual among ferrichrome siderophores in comprising an octapeptide rather than hexapeptide sequence, and in incorporating a glutamine residue...
  83. ncbi How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events
    Michael L Vasil
    University of Colorado at Denver and Health Sciences Center, 12800 E 19th Avenue RC 1 North P18 9127, Microbiology Mail Stop 8333, P O Box 6511, Aurora, CO 80045, USA
    Biometals 20:587-601. 2007
    ..g., expression and utilization of siderophores) or of iron-regulated genes involved in virulence (e.g., toxins)...
  84. pmc Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis
    Brian H Kvitko
    Department of Microbiology, Immunology and Pathology, Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS Negl Trop Dis 6:e1715. 2012
    ..pseudomallei used iron-acquisition systems commonly found in other bacteria, for example siderophores. However, our previous discovery of a clinical isolate carrying a large chromosomal deletion missing the entire ..
  85. ncbi Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877
    Francisco Barona-Gomez
    Department of Chemistry, University of Warwick, Coventry, UK
    Microbiology 152:3355-66. 2006
    ..ferric iron-chelators desferrioxamine E and coelichelin, respectively, which could potentially act as siderophores in the saprophyte Streptomyces coelicolor A3(2), has recently been reported...
  86. ncbi Separation and detection of siderophores produced by marine bacterioplankton using high-performance liquid chromatography with electrospray ionization mass spectrometry
    Paul McCormack
    School of Environmental Sciences, Plymouth Environmental Research Center, University of Plymouth, Plymouth, PL4 8AA, UK
    Anal Chem 75:2647-52. 2003
    ..ionization mass spectrometry was applied to the detection of the iron(III) complexes of the hydroxamate siderophores rhodotoluric acid, deferrioxamine B, and deferrichrome...
  87. pmc Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli
    Rebecca E Watts
    Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Infect Immun 80:333-44. 2012
    ..Here, we utilize ABU E. coli strain 83972 as a model to dissect the contribution of siderophores to iron acquisition, growth, fitness, and colonization of the urinary tract. We show that E...
  88. pmc Lipocalin 2 is protective against E. coli pneumonia
    Hong Wu
    Granulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark
    Respir Res 11:96. 2010
    ..coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs...
  89. pmc 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Nucl Med 51:639-45. 2010
    ..uses a specific and highly efficient iron uptake mechanism based on iron-complexing ferric ion Fe(III) siderophores, which are a requirement for A. fumigatus virulence...
  90. ncbi Iron acquisition with the natural siderophore enantiomers pyochelin and enantio-pyochelin in Pseudomonas species
    Zeb A Youard
    Département de Microbiologie Fondamentale, Universite de Lausanne, Bâtiment Biophore, Lausanne, Switzerland
    Biometals 24:513-22. 2011
    ..Both siderophores promote growth of the producer organism during iron limitation and induce the expression of their biosynthesis ..
  91. pmc ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response
    G Marcela Rodriguez
    TB Center, The Public Health Research Institute, Newark, New Jersey 07103, USA
    Infect Immun 70:3371-81. 2002
    ....
  92. ncbi Hydroxamate siderophores: occurrence and importance in the Atlantic Ocean
    Edward Mawji
    School of Ocean and Earth Science, National Oceanography Centre, University of Southampton, Southampton SO14 3ZH, United Kingdom
    Environ Sci Technol 42:8675-80. 2008
    b>Siderophores are chelates produced by bacteria as part of a highly specific iron uptake mechanism. They are thought to be important in the bacterial acquisition of iron in seawater and to influence iron biogeochemistry in the ocean...
  93. pmc Marine amphiphilic siderophores: marinobactin structure, uptake, and microbial partitioning
    Jennifer S Martinez
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106 9510, USA
    J Inorg Biochem 101:1692-8. 2007
    Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation...
  94. pmc Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system
    Hiroaki Naka
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Environ Microbiol 10:265-77. 2008
    ..Our results underscore the importance of the anguibactin system in the survival of V. anguillarum 775 under conditions of iron limitation...
  95. pmc Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
    T Verne Lee
    AgResearch Structural Biology Laboratory, School of Biological Sciences, University of Auckland, Auckland 1142, New Zealand
    J Biol Chem 285:2415-27. 2010
    ..Thus, this new structure will provide a basis for improving prediction methods for eukaryotic NRPS enzymes that play important and diverse roles in the biology of fungi...
  96. pmc Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation
    Jung Yeop Lee
    Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e20777. 2011
    Bacillus anthracis produces two catecholate siderophores, petrobactin and bacillibactin, under iron-limited conditions...
  97. ncbi Evaluation of the siderophores production by Pseudomonas aeruginosa PSS
    María Elena Díaz de Villegas
    Dpto de Bioquímica, Cuban Institute for Research on Sugar Cane by Products Vía Blanca 804 y Carretera Central, P O Box 4026, La Habana, Cuba
    Rev Latinoam Microbiol 44:112-7. 2002
    b>Siderophores are compounds secreted under low iron stress, that act as a specific ferric iron chelate agents and due to their potentialities in the biological control of phytopathogenic fungi and bacteria, their study has been stimulated ..
  98. pmc The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain
    Michelle B Ryndak
    Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 225 Warren Street, Newark, New Jersey 07103, USA
    J Bacteriol 192:861-9. 2010
    ..have evolved various strategies including the synthesis and secretion of high-affinity iron chelators known as siderophores. The siderophores produced and secreted by Mycobacterium tuberculosis, exomycobactins, compete for iron with ..
  99. pmc Plasmid- and chromosome-encoded redundant and specific functions are involved in biosynthesis of the siderophore anguibactin in Vibrio anguillarum 775: a case of chance and necessity?
    Alejandro F Alice
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 187:2209-14. 2005
    ..We also identified in this cluster a chromosomal angA gene that is essential in anguibactin biosynthesis...
  100. ncbi Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis
    M Seifert
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Immunobiology 213:767-78. 2008
    ..fumigatus. This fungus synthesizes three major siderophores. It excretes triacetylfusarinine C to capture iron, while it accumulates ferricrocin and hydroxyferricrocin for ..
  101. ncbi Marine siderophores and microbial iron mobilization
    Alison Butler
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93111 9510, USA
    Biometals 18:369-74. 2005
    ..Like terrestrial bacterial, bacteria isolated from open ocean water often produce siderophores, which are low molecular weight chelating ligands that facilitate the microbial acquisition of iron...

Research Grants63

  1. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..RELEVANCE: Current iron chelation therapy such as deferoxamine (DFO) relies on chelators inspired by bacterial siderophores intended to retrieve biologically available iron...
  2. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..Iron in this pool is hypothesized to associate with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3...
  3. CONTROL OF BACTERIAL TOXINS BY VIRUSES AND PLASMIDS
    Randall K Holmes; Fiscal Year: 2013
    ..diphtheriae to use other siderophores (e.g., desferrioxamine, ferrichrome, rhizoferrin and the recently discovered siderophores from C...
  4. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..In this research, we will define the role of key Fbp system components in Bordetella utilization of ferric siderophores and characterize an apparently novel mechanism for utilization of ferrous iron...
  5. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..The mycobactins have been proposed as novel targets for TB drugs since these small-molecule iron-chelators (siderophores) produced by Mycobacterium tuberculosis (MTb) are responsible for obtaining iron from the human host, a process ..
  6. Iron transport in Shigella and pathogenic E.coli
    Shelley M Payne; Fiscal Year: 2012
    ..These include the synthesis and transport of low molecular weight iron binding compounds called siderophores and transport of ferric iron, ferrous iron or heme...
  7. Mechanisms and regulation of Mycobacterium tuberculosis iron acquisition
    Issar Smith; Fiscal Year: 2013
    ..The specific aims of the proposal are first, to understand how the major pathway of Mtb iron acquisition, using siderophores, functions...
  8. Antibody Targeting of KPC and NDM1
    Brad J Spellberg; Fiscal Year: 2013
    ..engineering monoclonal antibodies (MAbs) targeting consensus KPC and NDM enzymes and conjugating them to iron siderophores or not...
  9. Analysis of NGAL Metabolism Identifies a Therapy for Iron Overload
    Jonathan M Barasch; Fiscal Year: 2012
    ..Cell, 2002) when binding a family of novel cofactors called the catechols or else the related bacterial siderophores constructed from catechol...
  10. Biological Implications of Tetramic Acid
    Kim D Janda; Fiscal Year: 2010
    ..due to the tight and highly specific binding of iron(III) to C12-TA, comparable to known bacterial siderophores, we have hypothesized that this interaction may serve as a previously unrecognized primordial mechanism for ..
  11. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2013
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  12. Mechanisms and regulation of Mycobacterium tuberculosis iron acquisition
    Issar Smith; Fiscal Year: 2009
    ..The specific aims of the proposal are first, to understand how the major pathway of Mtb iron acquisition, using siderophores, functions...
  13. Assembly Line Biosynthesis of Bacterial Siderophores
    FRED L HEFFRON; Fiscal Year: 2012
    ..provided by applicant): The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  14. Salicylate production in siderophore biosynthesis
    Audrey L Lamb; Fiscal Year: 2012
    b>Siderophores are low molecular weight iron chelators produced by bacteria to scavenge iron from the environment, and are frequently required for bacterial virulence...
  15. Characterizing a novel hemophore from pathogenic and non-pathogenic mycobacteria.
    LISA M MCMATH; Fiscal Year: 2010
    ..Iron is essential for all forms of life, and is acquired by mycobacteria via molecules called siderophores. We have shifted this paradigm, as we have identified a novel iron acquisition pathway whereby iron is obtained ..
  16. Iron transport and its role in pathogenesis of Vibrio cholerae
    SHELLEY PAYNE; Fiscal Year: 2009
    ..These iron transport systems include the endogenous siderophore vibriobactin, receptors for exogenous siderophores and for heme, and ferric and ferrous iron uptake systems...
  17. Role of Lipocalin 2 Inflammatory Bowel Disease
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Specifically, Lcn2 exerts potent antibacterial activity mediated by sequestering bacterial siderophores and thereby preventing bacteria from scavenging iron from lower affinity host proteins...
  18. IRON LIPOCALIN NGAL IN KIDNEY DISEASE
    Jonathan M Barasch; Fiscal Year: 2013
    ..NGAL recognizes iron that is specifically targeted to bacteria by "siderophores" and non-specifically targeted by a "mammalian siderophore" called catechol (NatureChemical Biology, 2010), the ..
  19. Structures of Peptide Synthetases and Related Enzymes
    Andrew M Gulick; Fiscal Year: 2013
    ..NRPSs) are a family of multi-domain enzymes that catalyze the synthesis of peptide antibiotics and peptide siderophores. The NRPSs function as modular assembly lines with amino acids and peptide intermediates bound to the protein ..
  20. Intercalated Cells of the Distal Nephron Defend the Urinary System
    Neal Paragas; Fiscal Year: 2013
    ..NGAL is critical to innate immunity because it binds siderophores which bacteria require to import iron...
  21. Structure-function analyses of siderophore biosynthetic enzymes
    Audrey L Lamb; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Siderophores are low molecular weight iron chelators produced by bacteria to scavenge iron from the environment, and are frequently required for bacterial virulence...
  22. Synthesis of new classes of metal ion chelators for therapeutic applications
    Aravamudan S Gopalan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A common feature in most of the natural siderophores is that they are polydentate ligands, capable of binding iron (III) strongly, to give an octahedral 1:1 complex...
  23. Cooperation and conflict in microbial systems: sucrose metabolism in yeast
    Jeff Gore; Fiscal Year: 2012
    ..During the independent phase of the award, the candidate will extend the research to the cooperative and competitive interactions that govern the production of iron-scavenging siderophores by the bacteria E. coli.
  24. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    Derek S Tan; Fiscal Year: 2010
    ..b>Siderophores are iron-chelating natural products that mediate bacterial uptake of iron from the mammalian host, a process ..
  25. Culturing Uncultivatable Gut Microorganisms
    Kim Lewis; Fiscal Year: 2012
    ..An assay-driven purification lead to the identification of siderophores as essential factors produced by helper organisms that trigger growth of uncultivatable bacteria from marine ..
  26. Mycobacterial Siderophores: Assembly, Assembly Inhibition, and Role in Virulence
    LUIS E QUADRI; Fiscal Year: 2010
    ..The long-term goal of this project is to elucidate the biosynthesis of mycobacterial siderophores (iron-scavenging compounds) that are required for multiplication of M...
  27. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..One such system involved in siderophore-mediated iron uptake, is the focus of this application. Siderophores are high-affinity iron chelators secreted from the bacterial cell to scavenge iron from host iron-binding ..
  28. RECEPTOR MEDIATED UPTAKE OF IRON COMPLEXES IN BACTERIA
    MARK MCINTOSH; Fiscal Year: 1999
    ..the molecular processes by which Escherichia coli and related organisms actively transport iron complexed to siderophores or iron-binding proteins to satisfy their nutritional iron requirements...
  29. Iron acquistion in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2003
    ..and also expresses activities required for the utilization of host heme compounds as well as certain non-native siderophores, including the potent and ubiquitous catechol siderophore enterobactin...
  30. STRUCTURES OF SIDEROPHORE MEMBRANE TRANSPORT PROTEINS
    Dick van der Helm; Fiscal Year: 2000
    Many aerobic microorganisms produce siderophores which are secreted into the environment. The siderophores chelate Fe3+ specifically. The complexation constants are very high (10\22-10/50). The complexes are too large (M.W...
  31. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..Erythrocytes, bacteria and bacterial siderophores, and ferritin-loaded liposomes (used as models of eukaryotic cells) will be used...
  32. BIOLOGICAL EVALUATION OF NEW ACTINIDE CHELATING AGENTS
    Patricia Durbin; Fiscal Year: 1999
    ..that synthetic ligands containing the bidentate Fe(III)-binding groups of microbial iron-sequestering agents (siderophores) would stably complex Pu at Ph 7 and spare essential divalent metals...
  33. SIDEROPHORES, ANALOGS AND BIOCONJUGATES
    Marvin Miller; Fiscal Year: 1999
    ..The general hypothesis to be tested is that syntheses and studies of microbial iron chelators (siderophores), analogs and conjugates with antimicrobial agents will facilitate the design of novel, actively transported, ..
  34. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    James McCusker; Fiscal Year: 1999
    ..area of bioinorganic chemistry, where EPR spectroscopy is an important technique for the characterization of Fe siderophores, as well as interatomic interactions in supramolecular assemblies...
  35. BIOSYNTHESIS AND REGULATION OF AROMATICS IN PSEUDOMONAS
    Roy Jensen; Fiscal Year: 1992
    ..pathway as a source of the latter essential metabolites as well as for pyocyanine pigment and iron-binding siderophores. Thus, an ideal basis exists for manipulation of the host-pathogen relationship since a multiplicity of enzyme ..
  36. HAEMOPHILUS INFLUENZAE PATHOGENESIS--ACQUISTION OF IRON
    Terrence Stull; Fiscal Year: 1990
    ..influenzae type b. The presence of low molecular weight iron-binding compounds called siderophores will be investigated by biochemical assays for phenolates and hydroxamates and bioassays using mutants to ..
  37. Metal Repressor Targets and Peptide Activators
    Robert Harrison; Fiscal Year: 2002
    ..sequences upstream of virulence genes, which control the expression of such products as diphtheria toxin, siderophores and heme-oxygenase...
  38. Iron regulation in candida albicans
    Simon Knight; Fiscal Year: 2006
    ..A siderophore system mediates uptake of the ferrichrome type siderophores and requires the transporter encoded by CaSIT1...
  39. FERRI-SIDEROPHORE RECEPTORS IN CANDIDA ALBICANS
    DAVID LUPAN; Fiscal Year: 1990
    ..Recent studies have shown that Candida albicans in response to iron starvation secretes low molecular weight siderophores which function to scavenge iron and return it to the yeast in a utilizable form...
  40. Nasal carriage of S. aureus: host-pathogen interactions
    Alexander M Cole; Fiscal Year: 2010
    ..The protein expression levels of a major host defense polypeptide, lipocalin-1 (a scavenger of bacterial siderophores), was found to be reduced in human nasal fluid from donors whose nasal passageways were colonized by SA...
  41. Use of Gallium to Prevent Pseudomonas Biofilm Formation
    Bradley Britigan; Fiscal Year: 2005
    ..aeruginosa, as well as characterize the interaction of Ga with its siderophores. DNA microarray technology will be used to study the impact of Ga on P. aeruginosa gene regulation...
  42. TANDEM MASS SPECTROMETER FOR BIOMOLECULAR ANALYSIS
    Glenn Dryhurst; Fiscal Year: 1999
    ..metabolites of biogenic amine neurotransmitters in aberrant brain chemistry, identification of bacterial siderophores, determination of physical binding donors to metalloporphyrins containing Ru or Os, determination of the ..
  43. MICROBIAL IRON TRANSPORT
    BENJAMIN BYERS; Fiscal Year: 1980
    ..Many microorganisms excrete high affinity iron chelating agents which function as iron transport cofactors (siderophores). These chelating agents usually are secondary hydroxamates or derivatives of 2,3-dihydroxybenzoic acid...
  44. IRON ACQUISITION BY STAPHYLOCOCCI
    Loreen Herwaldt; Fiscal Year: 1993
    ..evaluated to determine whether they have a role in iron acquisition by staphylococci: bacterial iron chelators (siderophores), bacterial reductases, bacteria- or host-derived organic acids. Mechanisms used by S...
  45. NCRR Shared Instrumentation/1H (13C/15N) 5mm Cold Probe
    Frederick Dahlquist; Fiscal Year: 2005
    ..proteins present in pyelonephritis-associated pili; the structure an assembly of tau protein; structural elucidation of marine siderophores; proteins and models of biomineralization; and kinetic analysis of the acetylcholine transporter.
  46. ROTATING ANODE X-RAY DIFFRACTION SYSTEM
    W Scheidt; Fiscal Year: 1991
    ..Structures of siderophores and siderophore-antibiotic conjugates are expected to provide a better understanding of the active and inactive ..
  47. Histoplasma capsulatum Iron Acquisition and Utilization
    JON WOODS; Fiscal Year: 2006
    ..Hc produces extracellular hydroxamate siderophores during iron-limited growth in vitro...
  48. Analysis of Toxin A synthesis in P. aeruginosa
    Abdul Hamood; Fiscal Year: 2006
    Exotoxin A and the siderophores (pyochelin and pyoverdine) are produced in P. aeruginosa by a complicated process that involves several genes...
  49. METAL BASED ANTIBIOTICS FOR TUBERCULOSIS
    Urszula Slomczynska; Fiscal Year: 1999
    ..Mycobactins, exochelins, and other siderophores function to sequester essential metals, particularly iron, within bacteria...
  50. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..pathogenesis of their infections, namely, enzymes that degrade oxidized or nitrosated proteins and synthesize siderophores; and how we can use gene therapy vectors to target exogenous antigen into the appropriate compartments of DC to ..
  51. Arrays of Receptors for Infectious Disease Diagnosis
    Frances Ligler; Fiscal Year: 2005
    ..The candidates will include antibodies, oligosaccharides, adhesions, siderophores, combinatorial peptides which bind membrane proteins on the pathogen, and antibiotics...
  52. AMINO ACID ANALYZER AND UPDATE OF PROTEIN SEQUENCER
    Mark Olson; Fiscal Year: 1990
    ..6) The amino acid content of newly isolated bacterial siderophores will be analyzed...
  53. SIDEROPHORES, IRON AND VIRULENCE
    BENJAMIN BYERS; Fiscal Year: 1990
  54. Metals in biology and Graduate Research Seminar
    Alison Butler; Fiscal Year: 2004
    ..To ensure the best possible programs, it is important that the cost of participating in the conference not be an impediment to the attendance of the invited speakers and discussion chairs. ..
  55. Iron Uptake and Virulence of Burkholderia pseudomallei
    JORGE CROSA; Fiscal Year: 2005
    ..2. The characterization and structural analysis of siderophores from B. pseudomallei and B. mallei...
  56. Virulence-conferring siderophore biosynthesis inhibitors
    LUIS QUADRI; Fiscal Year: 2006
    ..Many lines of evidence indicate that iron acquisition systems based on iron-chelators, referred to as siderophores, are required for the virulence of these pathogens...
  57. Investigations of the Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2009
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  58. Siderophore transport mechanism via membrane receptors
    Ranjan Chakraborty; Fiscal Year: 2004
    ..of the conserved regions through multiple sequence alignment of the 19-receptor proteins transporting ferric siderophores. These residues will be mutated and analyzed first in FepA to identify mutants with normal binding and ..