Research Topics

Genomes and Genes

Species

siderophores

Summary

Summary: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

Top Publications

  1. ncbi Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
  2. ncbi SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
  3. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
  4. ncbi Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-16, 10 Center Drive, MSC 1800, Bethesda, MD 20892-1800, USA
    Eukaryot Cell 7:20-7. 2008
  5. ncbi HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
  6. ncbi HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
  7. ncbi Siderophores from neighboring organisms promote the growth of uncultured bacteria
    Anthony D'Onofrio
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, Boston, MA 02115, USA
    Chem Biol 17:254-64. 2010
  8. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
  9. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
  10. ncbi Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii
    Daniel L Zimbler
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Biometals 22:23-32. 2009

Research Grants

  1. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2004
  2. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2007
  3. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
  4. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
  5. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
  6. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
  7. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
  8. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    LAXMINARAYANA DEVIREDDY; Fiscal Year: 2009
  9. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2010
  10. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004

Detail Information

Publications300 found, 100 shown here

  1. ncbi Siderophore-based iron acquisition and pathogen control
    Marcus Miethke
    Philipps Universitat Marburg, FB Chemie Biochemie, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Microbiol Mol Biol Rev 71:413-51. 2007
    ..Due to the key role of many siderophores during virulence, coevolution led to sophisticated strategies of siderophore neutralization by mammals and (re)..
  2. ncbi SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..Furthermore, A. fumigatus utilizes two intracellular siderophores, ferricrocin and hydroxyferricrocin, to store iron...
  3. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..Some invading bacteria respond by producing specific iron chelators-siderophores-that remove the iron from the host sources...
  4. ncbi Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-16, 10 Center Drive, MSC 1800, Bethesda, MD 20892-1800, USA
    Eukaryot Cell 7:20-7. 2008
  5. ncbi HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
    Won Hee Jung
    Department of Biotechnology, Chung Ang University, Gyeonggi Do, Republic of Korea
    PLoS Pathog 6:e1001209. 2010
    ..Overall, these results indicated that C. neoformans employs multiple strategies for iron acquisition during infection...
  6. ncbi HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
    ..Pathways positively affected by HapX include production of the ribotoxin AspF1 and siderophores, which are known virulence determinants...
  7. ncbi Siderophores from neighboring organisms promote the growth of uncultured bacteria
    Anthony D'Onofrio
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, Boston, MA 02115, USA
    Chem Biol 17:254-64. 2010
    ..The growth factors produced by one cultured helper strain were identified as new acyl-desferrioxamine siderophores. A panel of previously uncultured isolates exhibited a range of siderophore promiscuity for growth promotion...
  8. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
    ..we discuss the most recent findings on the mechanisms involved in maintaining iron homeostasis with a focus on siderophores, low-molecular-mass iron chelators, employed for iron uptake and storage...
  9. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
    Pyoverdines are a group of structurally related siderophores produced by fluorescent Pseudomonas species...
  10. ncbi Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii
    Daniel L Zimbler
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Biometals 22:23-32. 2009
    ..Unexpectedly, the ability of this pathogen to acquire iron depends on the expression of a SecA protein secretion function, which has not been associated with iron acquisition in bacteria...
  11. ncbi Molecular mechanisms of iron uptake in fungi
    Daniel J Kosman
    Department of Biochemistry, 140 Farber Hall, The University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Mol Microbiol 47:1185-97. 2003
    ..The integration of these multiple uptake mechanisms and their regulation into over-all iron homeostasis in yeast concludes this brief review...
  12. ncbi Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
    ..By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, ..
  13. ncbi Chemistry and biology of siderophores
    Robert C Hider
    Division of Pharmaceutical Science, King s College, London, SE1 9NH, UK
    Nat Prod Rep 27:637-57. 2010
    b>Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment...
  14. ncbi Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron
    Peter Hortschansky
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
    EMBO J 26:3157-68. 2007
    ..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
  15. ncbi Iron and fungal pathogenesis: a case study with Cryptococcus neoformans
    Won Hee Jung
    The Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Cell Microbiol 10:277-84. 2008
    ..neoformans is in host tissue. Achieving these goals may contribute to an understanding of the notable predilection of the fungus for the mammalian central nervous system...
  16. ncbi 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Nucl Med 51:639-45. 2010
    ..uses a specific and highly efficient iron uptake mechanism based on iron-complexing ferric ion Fe(III) siderophores, which are a requirement for A. fumigatus virulence...
  17. ncbi Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport
    Caleb W Dorsey
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Microbiology 149:1227-38. 2003
    ..pestis phosphopantetheinyl transferase, all of them involved in the assembly and utilization of catechol siderophores in other bacteria, were found next to the dhbACEB locus. This A...
  18. ncbi The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 12:1035-41. 2010
    ..To ensure an adequate supply with iron, Aspergillus fumigatus employs extra- and intracellular siderophores (low-molecular mass iron chelators), which are of importance for fungal growth in particular during iron ..
  19. ncbi The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans
    Martin Eisendle
    Division of Molecular Biology/Biocenter, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria
    Eukaryot Cell 5:1596-603. 2006
    ....
  20. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
    ..In many cases, this involves the secretion and internalisation of extracellular ferric chelators called siderophores. Ferrous iron can also be directly imported by the G protein-like transporter, FeoB...
  21. ncbi Role of the Fur regulon in iron transport in Bacillus subtilis
    Juliane Ollinger
    Department of Microbiology, Cornell University, Ithaca, NY 14853-8101, USA
    J Bacteriol 188:3664-73. 2006
    ..the intact bacillibactin siderophore is restored (by the introduction of a functional sfp gene) or exogenous siderophores are provided...
  22. ncbi Chemical aspects of siderophore mediated iron transport
    Hakim Boukhalfa
    Department of Chemistry, Duke University, Durham, NC 27708-0346, USA
    Biometals 15:325-39. 2002
    ..Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells...
  23. ncbi Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus
    Anja Wallner
    Biocenter, Medical University of Innsbruck, Austria
    Appl Environ Microbiol 75:4194-6. 2009
    ..Thus, ferricrocin represents the first intracellular iron transporter identified in any organism...
  24. ncbi The phytopathogen Pseudomonas syringae pv. tomato DC3000 has three high-affinity iron-scavenging systems functional under iron limitation conditions but dispensable for pathogenesis
    Alexander M Jones
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    J Bacteriol 193:2767-75. 2011
    High-affinity iron scavenging through the use of siderophores is a well-established virulence determinant in mammalian pathogenesis. However, few examples have been reported for plant pathogens...
  25. ncbi Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system
    Hiroaki Naka
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Environ Microbiol 10:265-77. 2008
    ..Our results underscore the importance of the anguibactin system in the survival of V. anguillarum 775 under conditions of iron limitation...
  26. ncbi The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis
    Graeme L Card
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Biol Chem 280:13978-86. 2005
    ....
  27. ncbi Iron uptake and metabolism in pseudomonads
    Pierre Cornelis
    Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium
    Appl Microbiol Biotechnol 86:1637-45. 2010
    ..Like for other bacteria, iron is a key nutrient for pseudomonads. The fluorescent pseudomonads produce siderophores, the best known being the fluorescent high-affinity peptidic pyoverdines...
  28. ncbi Microbial siderophores exert a subtle role in Arabidopsis during infection by manipulating the immune response and the iron status
    Alia Dellagi
    Laboratoire des Interactions Plantes Pathogènes, UMR 217, INRA AgroParisTech Université Pierre et Marie Curie, 75231 Paris Cedex 05, France
    Plant Physiol 150:1687-96. 2009
    b>Siderophores (ferric ion chelators) are secreted by organisms in response to iron deficiency...
  29. ncbi Siderophore-mediated iron transport in Bacillus subtilis and Corynebacterium glutamicum
    Emily A Dertz
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720 1460, USA
    J Biol Inorg Chem 11:1087-97. 2006
    ..Although both are triscatecholamide trilactones, the structural differences of these two siderophores result in opposite metal chiralities, different affinity for ferric ion, and dissimilar iron transport ..
  30. ncbi Thioquinolobactin, a Pseudomonas siderophore with antifungal and anti-Pythium activity
    Sandra Matthijs
    Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Building E, Pleinlaan 2, 1050 Brussels, Belgium
    Environ Microbiol 9:425-34. 2007
    Under conditions of iron limitation Pseudomonas fluorescens ATCC 17400 produces two siderophores, pyoverdine, and a second siderophore quinolobactin, which itself results from the hydrolysis of the unstable molecule 8-hydroxy-4-methoxy-2-..
  31. ncbi Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Roma, Italy
    Res Microbiol 162:279-84. 2011
    ..The results demonstrated that all A. baumannii isolates tested share the coding potential for two endogenous siderophores, a heme-acquisition and a ferrous iron-uptake system...
  32. ncbi Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents
    Marvin J Miller
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Biometals 22:61-75. 2009
    ..and active transport relies on the biosyntheses and use of microbe-selective iron-chelating compounds called siderophores. Our studies, and those of others, demonstrate that siderophores and analogs can be used for iron transport-..
  33. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
    ..Here we report that NGAL tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent ..
  34. ncbi Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization
    Lena H Hwang
    Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 4:e1000044. 2008
    ..H. capsulatum acquires iron through the action of ferric reductases and the production of siderophores, but the genes responsible for these activities and their role in virulence have not been determined...
  35. ncbi Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus
    Johnson Cheung
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mol Microbiol 74:594-608. 2009
    b>Siderophores are iron-scavenging molecules produced by many microbes. In general, they are synthesized using either non-ribosomal peptide synthetase (NRPS) or NRPS-independent siderophore (NIS) pathways...
  36. ncbi Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores
    A H T Hissen
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Infect Immun 72:1402-8. 2004
    ..fumigatus. In human serum, all of the monoferric transferrin was converted to apoTf within 8 h. Siderophores were secreted by A. fumigatus after 8 h of growth in MEM-serum and 12 h in MEM-holoTf...
  37. ncbi Hydroxamate siderophores: occurrence and importance in the Atlantic Ocean
    Edward Mawji
    School of Ocean and Earth Science, National Oceanography Centre, University of Southampton, Southampton SO14 3ZH, United Kingdom
    Environ Sci Technol 42:8675-80. 2008
    b>Siderophores are chelates produced by bacteria as part of a highly specific iron uptake mechanism. They are thought to be important in the bacterial acquisition of iron in seawater and to influence iron biogeochemistry in the ocean...
  38. ncbi A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
    Gregory L Challis
    Department of Chemistry, Warwick University, Coventry CV4 7AL, UK
    Chembiochem 6:601-11. 2005
  39. ncbi Cooperation and competition in pathogenic bacteria
    Ashleigh S Griffin
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Nature 430:1024-7. 2004
    ..The cooperative trait that we examine is the production of siderophores, iron-scavenging agents, in the pathogenic bacterium Pseudomonas aeruginosa...
  40. ncbi SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans
    H Oberegger
    Department of Microbiology, Medical School, University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria
    Mol Microbiol 41:1077-89. 2001
    Under conditions of low iron availability, most fungi excrete siderophores in order to mobilize extracellular iron...
  41. ncbi Bacterial iron sources: from siderophores to hemophores
    Cécile Wandersman
    Unité des Membranes Bactériennes, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 75724 Paris Cedex 15, France
    Annu Rev Microbiol 58:611-47. 2004
    ..The second mechanism relies on molecules (siderophores and hemophores) synthesized and released by bacteria into the extracellular medium; these molecules scavenge ..
  42. ncbi Pseudomonas fluorescens CHA0 produces enantio-pyochelin, the optical antipode of the Pseudomonas aeruginosa siderophore pyochelin
    Zeb A Youard
    Département de Microbiologie Fondamentale, Universite de Lausanne, Bâtiment Biophore, Quartier UNIL Sorge, CH 1015 Lausanne, Suisse
    J Biol Chem 282:35546-53. 2007
    ..aeruginosa siderophore pyochelin. Enantio-pyochelin was chemically synthesized and confirmed to be active in CHA0. Its potential biosynthetic pathway in CHA0 is discussed...
  43. ncbi Plasmid- and chromosome-encoded redundant and specific functions are involved in biosynthesis of the siderophore anguibactin in Vibrio anguillarum 775: a case of chance and necessity?
    Alejandro F Alice
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 187:2209-14. 2005
    ..We also identified in this cluster a chromosomal angA gene that is essential in anguibactin biosynthesis...
  44. ncbi Impact of siderophore production by Pseudomonas syringae pv. syringae 22d/93 on epiphytic fitness and biocontrol activity against Pseudomonas syringae pv. glycinea 1a/96
    Annette Wensing
    School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
    Appl Environ Microbiol 76:2704-11. 2010
    ..In this work we demonstrated that P. syringae pv. syringae 22d/93 produced a significantly larger amount of siderophores than the pathogen P. syringae pv. glycinea produced. While P. syringae pv. syringae 22d/93 and P. syringae pv...
  45. ncbi TonB-dependent outer-membrane proteins and siderophore utilization in Pseudomonas fluorescens Pf-5
    Sierra L Hartney
    Department of Botany and Plant Pathology, Oregon State University, 2082 Cordley Hall, Corvallis, OR 97331, USA
    Biometals 24:193-213. 2011
    The soil bacterium Pseudomonas fluorescens Pf-5 produces two siderophores, a pyoverdine and enantio-pyochelin, and its proteome includes 45 TonB-dependent outer-membrane proteins, which commonly function in uptake of siderophores and ..
  46. ncbi The role of siderophores in iron acquisition by photosynthetic marine microorganisms
    Brian M Hopkinson
    Department of Geosciences, Princeton University, NJ 08544, USA
    Biometals 22:659-69. 2009
    ..Neither group appears to produce siderophores, although some coastal cyanobacteria do...
  47. ncbi Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis
    M Seifert
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Immunobiology 213:767-78. 2008
    ..fumigatus. This fungus synthesizes three major siderophores. It excretes triacetylfusarinine C to capture iron, while it accumulates ferricrocin and hydroxyferricrocin for ..
  48. ncbi Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005
    ..transport capabilities for utilizing plant-derived compounds, the apparent ability to use a diversity of iron siderophores, detoxification systems to protect from oxidative stress, and the lack of a type III secretion system and ..
  49. ncbi Marine siderophores and microbial iron mobilization
    Alison Butler
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93111 9510, USA
    Biometals 18:369-74. 2005
    ..Like terrestrial bacterial, bacteria isolated from open ocean water often produce siderophores, which are low molecular weight chelating ligands that facilitate the microbial acquisition of iron...
  50. ncbi Metalloregulation in Bacillus subtilis: isolation and characterization of two genes differentially repressed by metal ions
    L Chen
    Section of Microbiology, Cornell University, Ithaca, New York 14853
    J Bacteriol 175:5428-37. 1993
    ..Mutation of the putative iron box for gene mrgC leads to partial derepression in iron-replete medium...
  51. ncbi The role of iron in plant host-pathogen interactions
    D Expert
    Laboratoire de Pathologie Végétale, INRA INA P G, Paris, France
    Trends Microbiol 4:232-7. 1996
    ..These studies could lead to the development of new control strategies against microbial infections of plants...
  52. ncbi Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
    ..membrane transporter system, fbpABC, that is required for the utilization of multiple structurally distinct siderophores including alcaligin, enterobactin, ferrichrome, and desferrioxamine B...
  53. ncbi Iron nutrition and physiological responses to iron stress in Nitrosomonas europaea
    Xueming Wei
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331-2902, USA
    Arch Microbiol 186:107-18. 2006
    ..europaea was able to assimilate up to 70% of the available Fe in the medium even though it is unable to produce siderophores. Addition of exogenous siderophores to Fe-limited medium increased growth (final cell mass)...
  54. ncbi Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans
    Martin Eisendle
    Department of Molecular Biology, Medical University of Innsbruck, Austria
    Eukaryot Cell 3:561-3. 2004
    Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH...
  55. ncbi Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
    ....
  56. ncbi Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T
    Kazutoshi Mihara
    Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan
    Microbiology 150:2587-97. 2004
    ..Primer extension and RT-PCR analyses suggested that the Ab cluster, which includes 18 genes, is organized in seven transcriptional units originating from respective Fur-regulated promoter-operator regions...
  57. ncbi Collision-induced dissociation of three groups of hydroxamate siderophores: ferrioxamines, ferrichromes and coprogens/fusigens
    Edward Mawji
    School of Ocean and Earth Science, National Oceanography Centre, University of Southampton, Southampton SO14 3ZH, UK
    Rapid Commun Mass Spectrom 22:2195-202. 2008
    The behaviour of a series of hydroxamate siderophores--microbially produced iron complexes - was investigated using electrospray ionisation mass spectrometry (ESI-MS)...
  58. ncbi The siderophore pyoverdine of Pseudomonas syringae pv. tabaci 6605 is an intrinsic virulence factor in host tobacco infection
    Fumiko Taguchi
    The Graduate School of Natural Science and Technology, Okayama University, Tsushima naka 1 1 1, Okayama 700 8530, Japan
    J Bacteriol 192:117-26. 2010
    ..tabaci 6605 are indispensable for virulence in host tobacco infection and that AHL may negatively regulate tolerance to antibiotics...
  59. ncbi Chemistry of marine ligands and siderophores
    Julia M Vraspir
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    Ann Rev Mar Sci 1:43-63. 2009
    ..In the case of iron, siderophores have been identified and structurally characterized...
  60. ncbi Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections
    M B Visser
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, Alberta T2N 4N1, Canada
    Infect Immun 72:2850-7. 2004
    ..Pc715jfptA::tp and Pc715jorbA::tp produced smaller amounts of their corresponding siderophores. Both Pc715jorbA::tp and Pc715jfptA::tp were able to grow in iron starvation conditions in vitro...
  61. ncbi Iron uptake mechanisms and their regulation in pathogenic bacteria
    V Braun
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
    Int J Med Microbiol 291:67-79. 2001
    ..The few principal mechanisms that underly the large variety of iron supply systems will be presented, as well as cases, in which defined iron supply systems are related to virulence...
  62. ncbi A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production
    Laxminarayana R Devireddy
    Case Comprehensive Cancer Center and Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 141:1006-17. 2010
    ..Siderophore-depleted mammalian cells and zebrafish embryos fail to synthesize heme, an iron-dependent mitochondrial process. Our results reveal features of intracellular iron homeostasis that are conserved from bacteria through humans...
  63. ncbi Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex
    Guanhu Bao
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Chem Biol 6:602-9. 2010
    ..gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth...
  64. ncbi Identification and analysis of a siderophore biosynthetic gene cluster from Agrobacterium tumefaciens C58
    Michelle R Rondon
    Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA
    Microbiology 150:3857-66. 2004
    ..tumefaciens C58 will have a unique chemical structure. Production of the siderophore was not required for virulence of A. tumefaciens when tested with a standard stem inoculation assay...
  65. ncbi OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints
    Takahiro Aoyama
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Mol Biol 70:681-92. 2009
    ..These results suggest that OsYSL18 is an iron-phytosiderophore transporter involved in the translocation of iron in reproductive organs and phloem in joints...
  66. ncbi Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca
    Eric J Dimise
    Department of Chemistry, Boston College, Eugene F Merkert Chemistry Center, Chestnut Hill, MA 02467, USA
    Proc Natl Acad Sci U S A 105:15311-6. 2008
    ..adenylation domain specificity supports the assignment of this gene cluster as the producer of the fuscachelin siderophores. The proposed nonribosomal peptide biosynthetic pathway exhibits several atypical features, including a ..
  67. ncbi Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice
    Amanda Fortes Francisco
    Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Rua Costa Sena, 171, Campus Universitário Morro do Cruzeiro Cep 35 400 000 Ouro Preto, MG, Brazil
    Exp Parasitol 120:314-9. 2008
    ..The results demonstrate that modification in iron stores increases BZ efficacy...
  68. ncbi Characterization of the Acinetobacter baumannii Fur regulator: cloning and sequencing of the fur homolog gene
    C Daniel
    Bacteriology Laboratory, A Calmette Hospital, Centre Hospitalier Regional et Universitaire, Lille, France
    FEMS Microbiol Lett 170:199-209. 1999
    ..The fur gene is followed by a divergent open reading frame coding for the C-terminus of a putative PilU protein. Sequence analysis indicates that the Fur protein of A. baumannii was 63% identical to the Escherichia coli Fur protein...
  69. ncbi Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4
    Moriah Sandy
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106 9510, USA
    J Nat Prod 73:1038-43. 2010
    ..trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4)...
  70. ncbi Interference of quorum sensing in Pseudomonas syringae by bacterial epiphytes that limit iron availability
    Glenn F J Dulla
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    Environ Microbiol 12:1762-74. 2010
    ..between the ability of isogenic Escherichia coli strains to sequester iron via their production of different siderophores and their ability to suppress QS in Pss was also observed...
  71. ncbi Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in Streptomyces coelicolor A3(2)
    Prakash Patel
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 49:8033-42. 2010
    Under iron limitation, the Gram-positive bacterium Streptomyces coelicolor A3(2) excretes three siderophores of the hydroxamate type: desferrioxamine B, desferrioxamine E, and coelichelin...
  72. ncbi Linkage between catecholate siderophores and the multicopper oxidase CueO in Escherichia coli
    Gregor Grass
    Department of Soil, Water, and Environmental Science, University of Arizona, Shantz Bldg 38, Rm 424, Tucson, AZ 85721, USA
    J Bacteriol 186:5826-33. 2004
    ..The reaction product of the 2,3-dihydroxybenzoic acid oxidation by CueO that can complex Cu(II) ions was determined by gas chromatography-mass spectroscopy and identified as 2-carboxymuconate...
  73. ncbi Siderophore synthesis in Magnaporthe grisea is essential for vegetative growth, conidiation and resistance to oxidative stress
    Carolin Hof
    Institut für Biotechnologie und Wirkstoff Forschung e V, Kaiserslautern, Germany
    Fungal Genet Biol 46:321-32. 2009
    The plant pathogenic fungus Magnaporthe grisea excretes siderophores of the coprogen-type for iron acquisition and uses ferricrocin for intracellular iron storage...
  74. ncbi Siderophores of the Pseudomonadaceae sensu stricto (fluorescent and non-fluorescent Pseudomonas spp.)
    H Budzikiewicz
    , , Germany
    Fortschr Chem Org Naturst 87:81-237. 2004
  75. ncbi Synthesis, structure, and molecular dynamics of gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin
    Evgeny A Fadeev
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 126:12065-75. 2004
    A new general synthesis of the citrate-based siderophores acinetoferrin (Af) and schizokinen (Sz) and their analogues is described...
  76. ncbi Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis
    Marcus Miethke
    , Fachbereich Chemie/Biochemie, Marburg, Germany
    FEBS J 273:409-19. 2006
    Aryl acid adenylation domains are the initial enzymes for aryl-capping of catecholic siderophores in a plethora of microorganisms...
  77. ncbi Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants
    Najwa Braich
    School of Medical Sciences Pharmacology and Bosch Institute, University of Sydney, NSW 2006, Australia
    Analyst 133:877-80. 2008
    ..metal affinity chromatography (IMAC) has been used to capture from standard samples the hydroxamate-containing siderophores, acetohydroxamic acid (ahaH), suberodihydroxamic acid (shaH(2)) or desferrioxamine B (DFOB) in recoveries ..
  78. ncbi Catechol siderophores control tungsten uptake and toxicity in the nitrogen-fixing bacterium Azotobacter vinelandii
    Thomas Wichard
    Department of Geosciences, Princeton Environmental Institute, Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Environ Sci Technol 42:2408-13. 2008
    ..We showthatthe catechol siderophores produced by A...
  79. ncbi Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters
    Orestis Lazos
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Chem Biol 17:160-73. 2010
    ..gene clusters including two (nrps3 and nrps5) predicted to govern biosynthesis of nonribosomal peptide-based siderophores. We report here the production by S...
  80. ncbi Siderophores are not involved in Fe(III) solubilization during anaerobic Fe(III) respiration by Shewanella oneidensis MR-1
    Christine M Fennessey
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Appl Environ Microbiol 76:2425-32. 2010
    ..DeltaSO3031 was unable to synthesize siderophores or produce soluble organic Fe(III) during aerobic respiration yet retained the ability to solubilize and ..
  81. ncbi Characterization of siderophores from Ustilago maydis
    A D Budde
    USDA ARS, Plant Disease Resistance Research Unit, Department of Plant Pathology, University of Wisconsin, Madison 53706
    Mycopathologia 108:125-33. 1989
    Two siderophores, ferrichrome and ferrichrome A, were found in cultures of Ustilago maydis (DC) Corda. Both siderophores were found intracellularly and extracellularly...
  82. ncbi New synthetic siderophores and their beta-lactam conjugates based on diamino acids and dipeptides
    S Wittmann
    , Jena, Beutenbergstrasse 11, D-07745, Jena, Germany
    Bioorg Med Chem 10:1659-70. 2002
    Linking of siderophores to antibiotics improves the penetration and therefore increases the antibacterial activity of the antibiotics...
  83. ncbi Petrobactin-mediated iron transport in pathogenic bacteria: coordination chemistry of an unusual 3,4-catecholate/citrate siderophore
    Rebecca J Abergel
    Department of Chemistry, University of California, Berkeley, California 94720-1460, USA
    J Am Chem Soc 130:2124-5. 2008
  84. ncbi Significance of asymmetric sites in choosing siderophores as deferration agents
    R J Bergeron
    Department of Medicinal Chemistry, University of Florida, J Hillis Miller Health Science Center, Gainesville, Florida 32610, USA
    J Med Chem 44:2469-78. 2001
    ..Thus, by altering the stereochemistry of certain microbial siderophores, it is possible to generate deferration agents that are still effective at clearing iron from animals, yet do ..
  85. ncbi Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea
    Lars Robbel
    Department of Chemistry, Philipps University Marburg, Marburg, Germany
    FEBS J 277:663-76. 2010
    The class of nonribosomally assembled siderophores encompasses a multitude of structurally diverse natural products...
  86. ncbi Siderophore production by Fusarium venenatum A3/5
    M G Wiebe
    Sohngaardsholmsvej 49, Institute of Life Sciences, Aalborg University, DK 9000 Aalborg, Denmark
    Biochem Soc Trans 30:696-8. 2002
    ..03 h(-1). Siderophore production was greatest at pH 4.7 and was significantly reduced at pHs above 6.0. Siderophore production could be enhanced by providing insoluble iron instead of soluble iron in continuous flow cultures...
  87. ncbi The three-dimensional structure of the gallium complex of azoverdin, a siderophore of Azomonas macrocytogenes ATCC 12334, determined by NMR using residual dipolar coupling constants
    Emeric Wasielewski
    , Groupe de RMN, UMR 7104 CNRS, ESBS, , 67400 Illkirch, France
    Biochemistry 41:12488-97. 2002
    ..This compound is related to the pyoverdins, the peptidic siderophores of Pseudomonas, but differs in the site on the chromophore at which the peptide is covalently linked...
  88. ncbi High-performance liquid chromatography analyses of pyoverdin siderophores differentiate among phytopathogenic fluorescent Pseudomonas Species
    Alain Bultreys
    Département de Biotechnologie, Centre de Recherches Agronomiques de Gembloux, Ministère de la Région Wallonne, Direction Générale de l Agriculture, Belgium
    Appl Environ Microbiol 69:1143-53. 2003
    ....
  89. ncbi TonB-dependent iron acquisition: mechanisms of siderophore-mediated active transport
    G S Moeck
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Mol Microbiol 28:675-81. 1998
    ..Thus, TonB interacts preferentially and directly with ligand-loaded receptors. Such a mechanism ensures the productive use of cellular energy to drive active transport at the outer membrane...
  90. ncbi Secretion, but not overall synthesis, of catecholate siderophores contributes to virulence of extraintestinal pathogenic Escherichia coli
    Mélissa Caza
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Mol Microbiol 80:266-82. 2011
    Extraintestinal pathogenic Escherichia coli (ExPEC) use siderophores to sequester iron during infection. Enterobactin and salmochelins are catecholate siderophores produced by some ExPEC strains and other pathogenic enterobacteria...
  91. ncbi Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages
    Jeremy Hilty
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Med Mycol 49:633-42. 2011
    ..capsulatum yeasts is exquisitely sensitive to the availability of iron. As H. capsulatum produces hydroxamate siderophores, we sought to determine if siderophores were required for intracellular survival in MΦ, and in a murine model ..
  92. ncbi The siderophore-mediated iron acquisition systems of Acinetobacter baumannii ATCC 19606 and Vibrio anguillarum 775 are structurally and functionally related
    Caleb W Dorsey
    Department of Microbiology, 40 Pearson Hall, Miami University, Oxford, OH 45056, USA
    Microbiology 150:3657-67. 2004
    ..similarities, as well as the structural similarity of anguibactin and acinetobactin, suggested that these two siderophores could be utilized by both bacterial strains, a possibility that was confirmed by siderophore utilization ..
  93. ncbi Involvement of SirABC in iron-siderophore import in Staphylococcus aureus
    Suzanne E Dale
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Bacteriol 186:8356-62. 2004
    ..aureus and for full fitness of the bacterium in iron-restricted environments and demonstrate a function for S. aureus genes encoding proteins involved in the transport of an endogenously produced siderophore...
  94. ncbi A genetic locus required for iron acquisition in Mycobacterium tuberculosis
    R Krithika
    Chemical Biology Group, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Proc Natl Acad Sci U S A 103:2069-74. 2006
    Mycobactins are a family of membrane-associated siderophores required for Mycobacterium tuberculosis to adapt to its intracellular habitat...
  95. ncbi Identification and characterization of an iron-regulated gene, chtA, required for the utilization of the xenosiderophores aerobactin, rhizobactin 1021 and schizokinen by Pseudomonas aeruginosa
    Páraic Ó Cuív
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Microbiology 152:945-54. 2006
    ..The utilization of citrate hydroxamate siderophores by P. aeruginosa was demonstrated to be TonB1 dependent...
  96. ncbi Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression
    Effie Nurtjahja Tjendraputra
    Iron Metabolism and Chelation Program, Department of Pathology, University of Sydney, New South Wales 2006, Australia
    Blood 109:4045-54. 2007
    ..This is the first report linking Fe depletion-mediated growth suppression at G(1)/S to a mechanism inducing cyclin D1 proteolysis...
  97. ncbi Synthesis and iron-binding properties of quinolobactin, a siderophore from a pyoverdine-deficient Pseudomonas fluorescens
    A Moulinet du Dhardemare
    Laboratoire de Chimie Biomimetique, LEDSS, UMR CNRS 5616, Universite J Fourier, Grenoble Cedex 9, France
    Biometals 17:691-7. 2004
    ..25 resulting in a pFeIII value of 18.2 at pH 7.4. The UV-visible spectral parameters of the [FeL2] are in agreement with a complex containing two ligands coordinated to one Fe3+ cation through the oxygen and nitrogen quinoline atoms...
  98. ncbi Ternary complex formation facilitates a redox mechanism for iron release from a siderophore
    Kassy A Mies
    Department of Chemistry, Duke University, Durham, NC, 27708-0346, USA
    Biometals 19:115-26. 2006
    ..Reduction is followed by a rapid ligand exchange step where iron is released from ferrioxamine B to form tris-(BPDS)iron(II). The implications of these results for siderophore mediated iron transport and release are discussed...
  99. ncbi Complex regulation of AprA metalloprotease in Pseudomonas fluorescens M114: evidence for the involvement of iron, the ECF sigma factor, PbrA and pseudobactin M114 siderophore
    Bláithín Maunsell
    The BIOMERIT Research Centre, Microbiology Dept, National University of Ireland, Cork, Ireland
    Microbiology 152:29-42. 2006
    ....
  100. ncbi Growth stimulation of Brevibacterium sp. by siderophores
    W H Noordman
    NIZO Food Research, Ede, The Netherlands
    J Appl Microbiol 101:637-46. 2006
    To assess which types of siderophores are typically produced by Brevibacterium and how siderophore production and utilization traits are distributed within this genus.
  101. ncbi An iron-regulated outer-membrane protein specific to Bordetella bronchiseptica and homologous to ferric siderophore receptors
    B Beall
    Childhood and Respiratory Diseases Branch, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Microbiology 143:135-45. 1997
    ..bronchiseptica and B. pertussis. In addition, the hydroxamate siderophores ferrichrome and desferrioxamine B, and the iron source haemin were shown to be utilized independently of bfeA ..

Research Grants88

  1. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2004
    ..previous grant period the Principal Investigator discovered a new class of self-assembling amphiphilic peptide siderophores, the marinobactins and aquachelins, produced by two phylogenetically distinct genera within the marine gamma ..
  2. Iron acqisition in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2007
    ..and also expresses activities required for utilization of host heme compounds as well as certain non-native siderophores, including the potent siderophore enterobactin...
  3. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..In this research, we will define the role of key Fbp system components in Bordetella utilization of ferric siderophores and characterize an apparently novel mechanism for utilization of ferrous iron...
  4. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2010
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  5. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth N Raymond; Fiscal Year: 2011
    ..Iron is a limiting nutrient in microbial growth;bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  6. Coordination Chemistry of Microbial Iron Transport Compounds
    Kenneth Raymond; Fiscal Year: 2009
    ..Iron is a limiting nutrient in microbial growth; bacteria primarily obtain iron through production of siderophores, low molecular weight chelating agents with high ferric affinity and selectivity...
  7. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2010
    ..The mycobactins have been proposed as novel targets for TB drugs since these small-molecule iron-chelators (siderophores) produced by Mycobacterium tuberculosis (MTb) are responsible for obtaining iron from the human host, a process ..
  8. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    LAXMINARAYANA DEVIREDDY; Fiscal Year: 2009
    ..Iron in this pool is hypothesized to associate with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3...
  9. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2010
    ..Iron in this pool is hypothesized to associate with low-molecular-weight siderophores and this liganded iron is a target for carrier proteins such as lipocalin 24p3...
  10. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..One such system involved in siderophore-mediated iron uptake, is the focus of this application. Siderophores are high-affinity iron chelators secreted from the bacterial cell to scavenge iron from host iron-binding ..
  11. Role of Lipocalin 2 in host defense against Klebsiella pneumoniae infection
    Yvonne Chan; Fiscal Year: 2007
    ..Lipocalin 2 acts as a receptor for siderophores - bacterial-derived proteins that scavenge miniscule amounts of free iron needed for bacterial metabolism...
  12. HEMIN UTILIZATION BY P GINGIVALIS
    Caroline Genco; Fiscal Year: 1999
    ..The mechanisms involved in iron acquisition will be examined by 1) determining if B. gingivalis can utilize siderophores produced by other organisms, 2) if B. gingivalis does indeed produce its own siderophores, and 3) if B...
  13. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1993
    ..by iron requirement and unavailability, microorganisms secrete high-affinity iron-binding compounds called siderophores with several types of chemical structures found among the more than 100 compounds characterized to data...
  14. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2009
    The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  15. Assembly Line Biosynthesis of Bacterial Siderophores
    Jorge H Crosa; Fiscal Year: 2010
    The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  16. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2009
    The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum...
  17. DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 1993
    ..and that conjugates of antifungal agents with species specific or selective microbial iron transport agents (siderophores) can be used to actively transport antifungal agents directly into the cells of pathogenic organisms...
  18. ENERGY TRANSDUCTION BETWEEN MEMBRANES
    Kathleen Postle; Fiscal Year: 2010
    ..To acquire large, scarce, important nutrients such as iron-siderophores and vitamin B12, active transporters with sub-nanomolar affinities for their transport substrates are located ..
  19. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2009
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  20. GENETICS OF IRON ACQUISITION BY LEGIONELLA PNEUMOPHILA
    Nicholas Cianciotto; Fiscal Year: 2007
    ..our specific understanding of Lp physiology and pathogenesis as well as provide new general insight into siderophores and the mechanisms of iron acquisition, methyltransferases and aconitases as iron-responsive regulators, ..
  21. MOLECULAR ANALYSIS OF YERSINIABACTIN BIOSYNTHESIS
    Christopher Walsh; Fiscal Year: 2001
    Iron chelating siderophores and several peptide antibiotics are assembled by nonribosomal peptide synthase complexes via a thioltemplate mechanism...
  22. Assembly Line Biosynthesis of Bacterial Siderophores
    JORGE CROSA; Fiscal Year: 2005
    ..the applicant): The goal of this research is to understand the mechanism of biosynthesis of bacterial peptide siderophores. We use as a paradigm the peptide siderophore anguibactin that is produced by the pathogenic bacterium Vibrio ..
  23. Investigations of the Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2009
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  24. Investigations of the Bioinorganic Chemistry of Iron: New Siderophores
    Alison Butler; Fiscal Year: 2007
    ..of marine siderophore structures fall within two categories: 1) suites of self-assembling amphiphilic peptide siderophores including the marinobactins, aquachelins, amphibactins, ochrobactins and synechobactins, which are produced by ..
  25. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA ARMSTRONG; Fiscal Year: 2001
    ..can accumulate iron supplied by their native macrocyclic dihydroxamate siderophore, alcaligin, as well as siderophores produced by other microbial species...
  26. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2010
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  27. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2010
    ..for all living species, and the TB community thought that Mtb acquired its iron in vivo solely via its iron siderophores;thus our identification of a novel heme acquisition pathway whereby iron is obtained via the uptake of human ..
  28. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2007
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  29. Iron uptake mechanisms of francisella tularensis
    Girija Ramakrishnan; Fiscal Year: 2009
    ..Many microorganisms secrete small molecules called siderophores to chelate iron from a variety of sources. We have shown that the F...
  30. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2009
    ..for all living species, and the TB community thought that Mtb acquired its iron in vivo solely via its iron siderophores; thus our identification of a novel heme acquisition pathway whereby iron is obtained via the uptake of human ..